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Network neighborhood for query Sequence : OSTF1_MOUSE

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OSTF1_MOUSE
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OSTF1_MOUSE
θ value	6.44497e-115 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	467	Target Neighborhood Hits	467	Shared Neighborhood Hits	467
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OSTF1_HUMAN
θ value	2.6227e-108 (rank : 2)	NC score	0.995459 (rank : 2)
Query Neighborhood Hits	467	Target Neighborhood Hits	466	Shared Neighborhood Hits	458
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ANR12_HUMAN
θ value	2.0648e-12 (rank : 3)	NC score	0.603077 (rank : 140)
Query Neighborhood Hits	467	Target Neighborhood Hits	1081	Shared Neighborhood Hits	264
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

DAPK1_MOUSE
θ value	6.00763e-12 (rank : 4)	NC score	0.344668 (rank : 318)
Query Neighborhood Hits	467	Target Neighborhood Hits	1138	Shared Neighborhood Hits	296
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ACBD6_MOUSE
θ value	1.74796e-11 (rank : 5)	NC score	0.683673 (rank : 17)
Query Neighborhood Hits	467	Target Neighborhood Hits	305	Shared Neighborhood Hits	251
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ACBD6_HUMAN
θ value	2.28291e-11 (rank : 6)	NC score	0.677747 (rank : 26)
Query Neighborhood Hits	467	Target Neighborhood Hits	304	Shared Neighborhood Hits	249
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANKR2_HUMAN
θ value	3.89403e-11 (rank : 7)	NC score	0.701545 (rank : 6)
Query Neighborhood Hits	467	Target Neighborhood Hits	321	Shared Neighborhood Hits	256
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKR2_MOUSE
θ value	1.133e-10 (rank : 8)	NC score	0.704562 (rank : 3)
Query Neighborhood Hits	467	Target Neighborhood Hits	312	Shared Neighborhood Hits	256
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

GRB2_HUMAN
θ value	1.133e-10 (rank : 9)	NC score	0.489704 (rank : 204)
Query Neighborhood Hits	467	Target Neighborhood Hits	310	Shared Neighborhood Hits	203
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	1.133e-10 (rank : 10)	NC score	0.489077 (rank : 206)
Query Neighborhood Hits	467	Target Neighborhood Hits	312	Shared Neighborhood Hits	203
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

TNKS1_HUMAN
θ value	3.29651e-10 (rank : 11)	NC score	0.682511 (rank : 20)
Query Neighborhood Hits	467	Target Neighborhood Hits	477	Shared Neighborhood Hits	262
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR11_HUMAN
θ value	5.62301e-10 (rank : 12)	NC score	0.621774 (rank : 119)
Query Neighborhood Hits	467	Target Neighborhood Hits	1289	Shared Neighborhood Hits	276
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ARHG6_HUMAN
θ value	9.59137e-10 (rank : 13)	NC score	0.423178 (rank : 264)
Query Neighborhood Hits	467	Target Neighborhood Hits	376	Shared Neighborhood Hits	192
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_HUMAN
θ value	9.59137e-10 (rank : 14)	NC score	0.436715 (rank : 259)
Query Neighborhood Hits	467	Target Neighborhood Hits	347	Shared Neighborhood Hits	203
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

EHMT1_HUMAN
θ value	9.59137e-10 (rank : 15)	NC score	0.650640 (rank : 82)
Query Neighborhood Hits	467	Target Neighborhood Hits	417	Shared Neighborhood Hits	258
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

TNKS2_HUMAN
θ value	9.59137e-10 (rank : 16)	NC score	0.683713 (rank : 16)
Query Neighborhood Hits	467	Target Neighborhood Hits	361	Shared Neighborhood Hits	258
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ANR29_HUMAN
θ value	1.63604e-09 (rank : 17)	NC score	0.698380 (rank : 7)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	254
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ARHG7_MOUSE
θ value	1.63604e-09 (rank : 18)	NC score	0.442287 (rank : 255)
Query Neighborhood Hits	467	Target Neighborhood Hits	396	Shared Neighborhood Hits	206
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ANK2_HUMAN
θ value	2.13673e-09 (rank : 19)	NC score	0.622774 (rank : 117)
Query Neighborhood Hits	467	Target Neighborhood Hits	1615	Shared Neighborhood Hits	285
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ARHG6_MOUSE
θ value	2.79066e-09 (rank : 20)	NC score	0.428321 (rank : 261)
Query Neighborhood Hits	467	Target Neighborhood Hits	394	Shared Neighborhood Hits	197
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DAPK1_HUMAN
θ value	3.64472e-09 (rank : 21)	NC score	0.337207 (rank : 325)
Query Neighborhood Hits	467	Target Neighborhood Hits	1130	Shared Neighborhood Hits	293
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ANR23_MOUSE
θ value	4.76016e-09 (rank : 22)	NC score	0.697656 (rank : 9)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	257
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ANR44_HUMAN
θ value	6.21693e-09 (rank : 23)	NC score	0.680966 (rank : 23)
Query Neighborhood Hits	467	Target Neighborhood Hits	318	Shared Neighborhood Hits	259
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

EHMT2_MOUSE
θ value	6.21693e-09 (rank : 24)	NC score	0.626626 (rank : 113)
Query Neighborhood Hits	467	Target Neighborhood Hits	750	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

MIB1_HUMAN
θ value	8.11959e-09 (rank : 25)	NC score	0.653929 (rank : 79)
Query Neighborhood Hits	467	Target Neighborhood Hits	470	Shared Neighborhood Hits	256
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	8.11959e-09 (rank : 26)	NC score	0.653727 (rank : 80)
Query Neighborhood Hits	467	Target Neighborhood Hits	471	Shared Neighborhood Hits	256
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

ANR23_HUMAN
θ value	1.06045e-08 (rank : 27)	NC score	0.693847 (rank : 10)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	255
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

GRAP2_HUMAN
θ value	1.06045e-08 (rank : 28)	NC score	0.472342 (rank : 224)
Query Neighborhood Hits	467	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	1.06045e-08 (rank : 29)	NC score	0.475950 (rank : 218)
Query Neighborhood Hits	467	Target Neighborhood Hits	297	Shared Neighborhood Hits	194
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

MYPT2_HUMAN
θ value	1.06045e-08 (rank : 30)	NC score	0.661599 (rank : 57)
Query Neighborhood Hits	467	Target Neighborhood Hits	707	Shared Neighborhood Hits	260
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

ANKS1_HUMAN
θ value	1.38499e-08 (rank : 31)	NC score	0.659714 (rank : 63)
Query Neighborhood Hits	467	Target Neighborhood Hits	438	Shared Neighborhood Hits	265
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

CSKI1_MOUSE
θ value	1.38499e-08 (rank : 32)	NC score	0.647785 (rank : 94)
Query Neighborhood Hits	467	Target Neighborhood Hits	1031	Shared Neighborhood Hits	298
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
θ value	1.80886e-08 (rank : 33)	NC score	0.649616 (rank : 87)
Query Neighborhood Hits	467	Target Neighborhood Hits	997	Shared Neighborhood Hits	301
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EHMT2_HUMAN
θ value	2.36244e-08 (rank : 34)	NC score	0.637119 (rank : 104)
Query Neighborhood Hits	467	Target Neighborhood Hits	498	Shared Neighborhood Hits	256
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANK3_HUMAN
θ value	3.08544e-08 (rank : 35)	NC score	0.658985 (rank : 64)
Query Neighborhood Hits	467	Target Neighborhood Hits	853	Shared Neighborhood Hits	262
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANR50_HUMAN
θ value	3.08544e-08 (rank : 36)	NC score	0.685090 (rank : 15)
Query Neighborhood Hits	467	Target Neighborhood Hits	361	Shared Neighborhood Hits	258
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

BARD1_HUMAN
θ value	4.0297e-08 (rank : 37)	NC score	0.658896 (rank : 65)
Query Neighborhood Hits	467	Target Neighborhood Hits	427	Shared Neighborhood Hits	254
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

INVS_HUMAN
θ value	4.0297e-08 (rank : 38)	NC score	0.682712 (rank : 19)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

INVS_MOUSE
θ value	4.0297e-08 (rank : 39)	NC score	0.674766 (rank : 32)
Query Neighborhood Hits	467	Target Neighborhood Hits	609	Shared Neighborhood Hits	261
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ITSN1_MOUSE
θ value	4.0297e-08 (rank : 40)	NC score	0.323898 (rank : 334)
Query Neighborhood Hits	467	Target Neighborhood Hits	1669	Shared Neighborhood Hits	241
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SH3G2_HUMAN
θ value	4.0297e-08 (rank : 41)	NC score	0.464702 (rank : 233)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	192
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
θ value	4.0297e-08 (rank : 42)	NC score	0.470489 (rank : 228)
Query Neighborhood Hits	467	Target Neighborhood Hits	236	Shared Neighborhood Hits	186
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRC8_HUMAN
θ value	4.0297e-08 (rank : 43)	NC score	0.478445 (rank : 215)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	181
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	4.0297e-08 (rank : 44)	NC score	0.472233 (rank : 225)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	180
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ANKR6_HUMAN
θ value	6.87365e-08 (rank : 45)	NC score	0.691446 (rank : 12)
Query Neighborhood Hits	467	Target Neighborhood Hits	439	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANR52_HUMAN
θ value	6.87365e-08 (rank : 46)	NC score	0.669984 (rank : 38)
Query Neighborhood Hits	467	Target Neighborhood Hits	322	Shared Neighborhood Hits	259
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_MOUSE
θ value	6.87365e-08 (rank : 47)	NC score	0.670053 (rank : 37)
Query Neighborhood Hits	467	Target Neighborhood Hits	318	Shared Neighborhood Hits	259
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

BARD1_MOUSE
θ value	6.87365e-08 (rank : 48)	NC score	0.656556 (rank : 71)
Query Neighborhood Hits	467	Target Neighborhood Hits	411	Shared Neighborhood Hits	251
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

MYPT1_HUMAN
θ value	6.87365e-08 (rank : 49)	NC score	0.654675 (rank : 77)
Query Neighborhood Hits	467	Target Neighborhood Hits	723	Shared Neighborhood Hits	260
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
θ value	6.87365e-08 (rank : 50)	NC score	0.669952 (rank : 39)
Query Neighborhood Hits	467	Target Neighborhood Hits	539	Shared Neighborhood Hits	257
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ANR28_HUMAN
θ value	1.17247e-07 (rank : 51)	NC score	0.677447 (rank : 28)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	259
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_MOUSE
θ value	1.17247e-07 (rank : 52)	NC score	0.678683 (rank : 25)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	259
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR39_MOUSE
θ value	1.17247e-07 (rank : 53)	NC score	0.697969 (rank : 8)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	249
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ASB2_HUMAN
θ value	1.17247e-07 (rank : 54)	NC score	0.668061 (rank : 42)
Query Neighborhood Hits	467	Target Neighborhood Hits	309	Shared Neighborhood Hits	255
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ILK_MOUSE
θ value	1.17247e-07 (rank : 55)	NC score	0.484174 (rank : 208)
Query Neighborhood Hits	467	Target Neighborhood Hits	858	Shared Neighborhood Hits	288
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ITSN1_HUMAN
θ value	1.17247e-07 (rank : 56)	NC score	0.320509 (rank : 338)
Query Neighborhood Hits	467	Target Neighborhood Hits	1757	Shared Neighborhood Hits	238
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

CD2AP_HUMAN
θ value	1.53129e-07 (rank : 57)	NC score	0.504901 (rank : 195)
Query Neighborhood Hits	467	Target Neighborhood Hits	315	Shared Neighborhood Hits	196
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

RIPK4_HUMAN
θ value	1.53129e-07 (rank : 58)	NC score	0.475744 (rank : 219)
Query Neighborhood Hits	467	Target Neighborhood Hits	1094	Shared Neighborhood Hits	294
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

SH3G2_MOUSE
θ value	1.53129e-07 (rank : 59)	NC score	0.458364 (rank : 243)
Query Neighborhood Hits	467	Target Neighborhood Hits	319	Shared Neighborhood Hits	186
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ANKR1_MOUSE
θ value	1.99992e-07 (rank : 60)	NC score	0.690091 (rank : 13)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	254
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

PSD10_HUMAN
θ value	1.99992e-07 (rank : 61)	NC score	0.704525 (rank : 4)
Query Neighborhood Hits	467	Target Neighborhood Hits	301	Shared Neighborhood Hits	258
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

SH3G1_MOUSE
θ value	1.99992e-07 (rank : 62)	NC score	0.451952 (rank : 249)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	189
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
θ value	1.99992e-07 (rank : 63)	NC score	0.460522 (rank : 238)
Query Neighborhood Hits	467	Target Neighborhood Hits	222	Shared Neighborhood Hits	180
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ASB2_MOUSE
θ value	2.61198e-07 (rank : 64)	NC score	0.664117 (rank : 51)
Query Neighborhood Hits	467	Target Neighborhood Hits	321	Shared Neighborhood Hits	254
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

HCLS1_MOUSE
θ value	2.61198e-07 (rank : 65)	NC score	0.471239 (rank : 227)
Query Neighborhood Hits	467	Target Neighborhood Hits	329	Shared Neighborhood Hits	173
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

OSBL1_HUMAN
θ value	2.61198e-07 (rank : 66)	NC score	0.541319 (rank : 180)
Query Neighborhood Hits	467	Target Neighborhood Hits	368	Shared Neighborhood Hits	253
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PSD10_MOUSE
θ value	2.61198e-07 (rank : 67)	NC score	0.704271 (rank : 5)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	257
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

SH3G1_HUMAN
θ value	2.61198e-07 (rank : 68)	NC score	0.447668 (rank : 253)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	185
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ANKS1_MOUSE
θ value	3.41135e-07 (rank : 69)	NC score	0.650211 (rank : 85)
Query Neighborhood Hits	467	Target Neighborhood Hits	453	Shared Neighborhood Hits	265
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

TRPA1_MOUSE
θ value	3.41135e-07 (rank : 70)	NC score	0.660811 (rank : 58)
Query Neighborhood Hits	467	Target Neighborhood Hits	343	Shared Neighborhood Hits	255
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANK1_HUMAN
θ value	4.45536e-07 (rank : 71)	NC score	0.666674 (rank : 43)
Query Neighborhood Hits	467	Target Neighborhood Hits	416	Shared Neighborhood Hits	260
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ILK1_HUMAN
θ value	5.81887e-07 (rank : 72)	NC score	0.483928 (rank : 209)
Query Neighborhood Hits	467	Target Neighborhood Hits	857	Shared Neighborhood Hits	289
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	5.81887e-07 (rank : 73)	NC score	0.497429 (rank : 202)
Query Neighborhood Hits	467	Target Neighborhood Hits	848	Shared Neighborhood Hits	289
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

STAM2_HUMAN
θ value	5.81887e-07 (rank : 74)	NC score	0.440726 (rank : 257)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	194
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ANK1_MOUSE
θ value	7.59969e-07 (rank : 75)	NC score	0.664531 (rank : 48)
Query Neighborhood Hits	467	Target Neighborhood Hits	430	Shared Neighborhood Hits	259
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANKR1_HUMAN
θ value	7.59969e-07 (rank : 76)	NC score	0.687780 (rank : 14)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	252
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ASB11_HUMAN
θ value	7.59969e-07 (rank : 77)	NC score	0.649854 (rank : 86)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	236
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

CD2AP_MOUSE
θ value	7.59969e-07 (rank : 78)	NC score	0.503180 (rank : 197)
Query Neighborhood Hits	467	Target Neighborhood Hits	336	Shared Neighborhood Hits	201
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

FGR_HUMAN
θ value	7.59969e-07 (rank : 79)	NC score	0.194479 (rank : 409)
Query Neighborhood Hits	467	Target Neighborhood Hits	1067	Shared Neighborhood Hits	203
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HCLS1_HUMAN
θ value	7.59969e-07 (rank : 80)	NC score	0.474392 (rank : 222)
Query Neighborhood Hits	467	Target Neighborhood Hits	358	Shared Neighborhood Hits	175
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

STAM1_HUMAN
θ value	7.59969e-07 (rank : 81)	NC score	0.456450 (rank : 245)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	200
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	7.59969e-07 (rank : 82)	NC score	0.455785 (rank : 247)
Query Neighborhood Hits	467	Target Neighborhood Hits	273	Shared Neighborhood Hits	200
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
θ value	7.59969e-07 (rank : 83)	NC score	0.450561 (rank : 250)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	193
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TNI3K_MOUSE
θ value	7.59969e-07 (rank : 84)	NC score	0.392158 (rank : 286)
Query Neighborhood Hits	467	Target Neighborhood Hits	1079	Shared Neighborhood Hits	293
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CSKI2_HUMAN
θ value	9.92553e-07 (rank : 85)	NC score	0.660343 (rank : 60)
Query Neighborhood Hits	467	Target Neighborhood Hits	747	Shared Neighborhood Hits	299
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	9.92553e-07 (rank : 86)	NC score	0.664353 (rank : 50)
Query Neighborhood Hits	467	Target Neighborhood Hits	812	Shared Neighborhood Hits	302
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

TEX14_MOUSE
θ value	9.92553e-07 (rank : 87)	NC score	0.402392 (rank : 275)
Query Neighborhood Hits	467	Target Neighborhood Hits	1333	Shared Neighborhood Hits	273
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ANKK1_HUMAN
θ value	1.29631e-06 (rank : 88)	NC score	0.478357 (rank : 216)
Query Neighborhood Hits	467	Target Neighborhood Hits	1075	Shared Neighborhood Hits	291
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ASB10_HUMAN
θ value	1.29631e-06 (rank : 89)	NC score	0.670843 (rank : 36)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	251
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

BTK_MOUSE
θ value	1.29631e-06 (rank : 90)	NC score	0.169603 (rank : 432)
Query Neighborhood Hits	467	Target Neighborhood Hits	1017	Shared Neighborhood Hits	183
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

GABP2_MOUSE
θ value	1.29631e-06 (rank : 91)	NC score	0.675341 (rank : 29)
Query Neighborhood Hits	467	Target Neighborhood Hits	429	Shared Neighborhood Hits	259
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ITSN2_HUMAN
θ value	1.29631e-06 (rank : 92)	NC score	0.338620 (rank : 322)
Query Neighborhood Hits	467	Target Neighborhood Hits	1173	Shared Neighborhood Hits	222
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	1.29631e-06 (rank : 93)	NC score	0.327806 (rank : 332)
Query Neighborhood Hits	467	Target Neighborhood Hits	1371	Shared Neighborhood Hits	228
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SPTA2_HUMAN
θ value	1.29631e-06 (rank : 94)	NC score	0.204595 (rank : 403)
Query Neighborhood Hits	467	Target Neighborhood Hits	888	Shared Neighborhood Hits	185
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ANKK1_MOUSE
θ value	1.69304e-06 (rank : 95)	NC score	0.464151 (rank : 234)
Query Neighborhood Hits	467	Target Neighborhood Hits	1072	Shared Neighborhood Hits	289
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANR25_MOUSE
θ value	1.69304e-06 (rank : 96)	NC score	0.560087 (rank : 173)
Query Neighborhood Hits	467	Target Neighborhood Hits	398	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ASB11_MOUSE
θ value	1.69304e-06 (rank : 97)	NC score	0.652698 (rank : 81)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	236
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

YES_HUMAN
θ value	1.69304e-06 (rank : 98)	NC score	0.190200 (rank : 417)
Query Neighborhood Hits	467	Target Neighborhood Hits	1059	Shared Neighborhood Hits	202
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ANKR5_HUMAN
θ value	2.21117e-06 (rank : 99)	NC score	0.674976 (rank : 31)
Query Neighborhood Hits	467	Target Neighborhood Hits	297	Shared Neighborhood Hits	255
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ASB5_HUMAN
θ value	2.21117e-06 (rank : 100)	NC score	0.649578 (rank : 88)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	246
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

GABP2_HUMAN
θ value	2.21117e-06 (rank : 101)	NC score	0.673008 (rank : 35)
Query Neighborhood Hits	467	Target Neighborhood Hits	454	Shared Neighborhood Hits	258
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ABI1_MOUSE
θ value	2.88788e-06 (rank : 102)	NC score	0.441774 (rank : 256)
Query Neighborhood Hits	467	Target Neighborhood Hits	246	Shared Neighborhood Hits	176
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	2.88788e-06 (rank : 103)	NC score	0.460410 (rank : 239)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	192
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	2.88788e-06 (rank : 104)	NC score	0.462821 (rank : 236)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	189
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ASB9_MOUSE
θ value	2.88788e-06 (rank : 105)	NC score	0.644406 (rank : 97)
Query Neighborhood Hits	467	Target Neighborhood Hits	257	Shared Neighborhood Hits	226
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

CDN2C_HUMAN
θ value	2.88788e-06 (rank : 106)	NC score	0.664519 (rank : 49)
Query Neighborhood Hits	467	Target Neighborhood Hits	262	Shared Neighborhood Hits	240
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

DNMBP_HUMAN
θ value	2.88788e-06 (rank : 107)	NC score	0.403575 (rank : 271)
Query Neighborhood Hits	467	Target Neighborhood Hits	413	Shared Neighborhood Hits	192
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FYN_HUMAN
θ value	2.88788e-06 (rank : 108)	NC score	0.191369 (rank : 414)
Query Neighborhood Hits	467	Target Neighborhood Hits	1078	Shared Neighborhood Hits	208
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	2.88788e-06 (rank : 109)	NC score	0.194495 (rank : 408)
Query Neighborhood Hits	467	Target Neighborhood Hits	1073	Shared Neighborhood Hits	208
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

NCF2_HUMAN
θ value	2.88788e-06 (rank : 110)	NC score	0.485877 (rank : 207)
Query Neighborhood Hits	467	Target Neighborhood Hits	229	Shared Neighborhood Hits	174
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAC_HUMAN
θ value	2.88788e-06 (rank : 111)	NC score	0.454124 (rank : 248)
Query Neighborhood Hits	467	Target Neighborhood Hits	276	Shared Neighborhood Hits	188
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TRPA1_HUMAN
θ value	2.88788e-06 (rank : 112)	NC score	0.657548 (rank : 67)
Query Neighborhood Hits	467	Target Neighborhood Hits	339	Shared Neighborhood Hits	255
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

BTK_HUMAN
θ value	3.77169e-06 (rank : 113)	NC score	0.173451 (rank : 427)
Query Neighborhood Hits	467	Target Neighborhood Hits	1026	Shared Neighborhood Hits	191
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

RAI14_HUMAN
θ value	3.77169e-06 (rank : 114)	NC score	0.500086 (rank : 199)
Query Neighborhood Hits	467	Target Neighborhood Hits	1367	Shared Neighborhood Hits	274
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

STAC_MOUSE
θ value	3.77169e-06 (rank : 115)	NC score	0.446934 (rank : 254)
Query Neighborhood Hits	467	Target Neighborhood Hits	268	Shared Neighborhood Hits	187
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

YES_MOUSE
θ value	3.77169e-06 (rank : 116)	NC score	0.191167 (rank : 415)
Query Neighborhood Hits	467	Target Neighborhood Hits	1052	Shared Neighborhood Hits	203
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZDH17_HUMAN
θ value	3.77169e-06 (rank : 117)	NC score	0.591979 (rank : 150)
Query Neighborhood Hits	467	Target Neighborhood Hits	334	Shared Neighborhood Hits	253
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ABI1_HUMAN
θ value	4.92598e-06 (rank : 118)	NC score	0.427506 (rank : 262)
Query Neighborhood Hits	467	Target Neighborhood Hits	257	Shared Neighborhood Hits	174
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ANKR5_MOUSE
θ value	4.92598e-06 (rank : 119)	NC score	0.673696 (rank : 33)
Query Neighborhood Hits	467	Target Neighborhood Hits	298	Shared Neighborhood Hits	254
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR25_HUMAN
θ value	4.92598e-06 (rank : 120)	NC score	0.566292 (rank : 166)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	237
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

MYO1E_HUMAN
θ value	4.92598e-06 (rank : 121)	NC score	0.193627 (rank : 411)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	184
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SRC_HUMAN
θ value	4.92598e-06 (rank : 122)	NC score	0.186869 (rank : 423)
Query Neighborhood Hits	467	Target Neighborhood Hits	1058	Shared Neighborhood Hits	206
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TNI3K_HUMAN
θ value	4.92598e-06 (rank : 123)	NC score	0.394126 (rank : 285)
Query Neighborhood Hits	467	Target Neighborhood Hits	1084	Shared Neighborhood Hits	295
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ASB10_MOUSE
θ value	6.43352e-06 (rank : 124)	NC score	0.669398 (rank : 40)
Query Neighborhood Hits	467	Target Neighborhood Hits	301	Shared Neighborhood Hits	256
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CDN2C_MOUSE
θ value	6.43352e-06 (rank : 125)	NC score	0.666492 (rank : 45)
Query Neighborhood Hits	467	Target Neighborhood Hits	270	Shared Neighborhood Hits	242
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

FGR_MOUSE
θ value	6.43352e-06 (rank : 126)	NC score	0.189399 (rank : 418)
Query Neighborhood Hits	467	Target Neighborhood Hits	1069	Shared Neighborhood Hits	201
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MIB2_HUMAN
θ value	6.43352e-06 (rank : 127)	NC score	0.641450 (rank : 98)
Query Neighborhood Hits	467	Target Neighborhood Hits	438	Shared Neighborhood Hits	257
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

OSBL1_MOUSE
θ value	6.43352e-06 (rank : 128)	NC score	0.530188 (rank : 188)
Query Neighborhood Hits	467	Target Neighborhood Hits	336	Shared Neighborhood Hits	251
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

GRAP_MOUSE
θ value	8.40245e-06 (rank : 129)	NC score	0.466262 (rank : 232)
Query Neighborhood Hits	467	Target Neighborhood Hits	309	Shared Neighborhood Hits	211
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

KRIT1_HUMAN
θ value	8.40245e-06 (rank : 130)	NC score	0.568927 (rank : 164)
Query Neighborhood Hits	467	Target Neighborhood Hits	258	Shared Neighborhood Hits	208
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

PP16A_MOUSE
θ value	8.40245e-06 (rank : 131)	NC score	0.659765 (rank : 62)
Query Neighborhood Hits	467	Target Neighborhood Hits	318	Shared Neighborhood Hits	253
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

SH3K1_HUMAN
θ value	8.40245e-06 (rank : 132)	NC score	0.498031 (rank : 200)
Query Neighborhood Hits	467	Target Neighborhood Hits	341	Shared Neighborhood Hits	198
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	8.40245e-06 (rank : 133)	NC score	0.497978 (rank : 201)
Query Neighborhood Hits	467	Target Neighborhood Hits	332	Shared Neighborhood Hits	200
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ANR10_MOUSE
θ value	1.09739e-05 (rank : 134)	NC score	0.657591 (rank : 66)
Query Neighborhood Hits	467	Target Neighborhood Hits	273	Shared Neighborhood Hits	237
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

MYO1F_MOUSE
θ value	1.09739e-05 (rank : 135)	NC score	0.197386 (rank : 406)
Query Neighborhood Hits	467	Target Neighborhood Hits	262	Shared Neighborhood Hits	189
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ZDH17_MOUSE
θ value	1.09739e-05 (rank : 136)	NC score	0.588328 (rank : 154)
Query Neighborhood Hits	467	Target Neighborhood Hits	328	Shared Neighborhood Hits	252
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

CTTB2_HUMAN
θ value	1.43324e-05 (rank : 137)	NC score	0.591388 (rank : 151)
Query Neighborhood Hits	467	Target Neighborhood Hits	1061	Shared Neighborhood Hits	268
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

KRIT1_MOUSE
θ value	1.43324e-05 (rank : 138)	NC score	0.577309 (rank : 163)
Query Neighborhood Hits	467	Target Neighborhood Hits	258	Shared Neighborhood Hits	216
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

VAV_MOUSE
θ value	1.43324e-05 (rank : 139)	NC score	0.358887 (rank : 310)
Query Neighborhood Hits	467	Target Neighborhood Hits	430	Shared Neighborhood Hits	186
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ASB9_HUMAN
θ value	1.87187e-05 (rank : 140)	NC score	0.650265 (rank : 84)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	232
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

VINEX_HUMAN
θ value	1.87187e-05 (rank : 141)	NC score	0.481012 (rank : 210)
Query Neighborhood Hits	467	Target Neighborhood Hits	270	Shared Neighborhood Hits	192
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	1.87187e-05 (rank : 142)	NC score	0.478979 (rank : 213)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	193
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ANKS6_HUMAN
θ value	2.44474e-05 (rank : 143)	NC score	0.656943 (rank : 70)
Query Neighborhood Hits	467	Target Neighborhood Hits	411	Shared Neighborhood Hits	258
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANR15_HUMAN
θ value	2.44474e-05 (rank : 144)	NC score	0.591002 (rank : 152)
Query Neighborhood Hits	467	Target Neighborhood Hits	478	Shared Neighborhood Hits	244
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANR39_HUMAN
θ value	2.44474e-05 (rank : 145)	NC score	0.693829 (rank : 11)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	250
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

MTPN_MOUSE
θ value	2.44474e-05 (rank : 146)	NC score	0.683119 (rank : 18)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	241
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYO1F_HUMAN
θ value	2.44474e-05 (rank : 147)	NC score	0.199046 (rank : 405)
Query Neighborhood Hits	467	Target Neighborhood Hits	275	Shared Neighborhood Hits	190
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

RAI14_MOUSE
θ value	2.44474e-05 (rank : 148)	NC score	0.478822 (rank : 214)
Query Neighborhood Hits	467	Target Neighborhood Hits	1505	Shared Neighborhood Hits	279
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANKS3_HUMAN
θ value	3.19293e-05 (rank : 149)	NC score	0.660391 (rank : 59)
Query Neighborhood Hits	467	Target Neighborhood Hits	355	Shared Neighborhood Hits	250
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANKS3_MOUSE
θ value	3.19293e-05 (rank : 150)	NC score	0.663341 (rank : 53)
Query Neighborhood Hits	467	Target Neighborhood Hits	355	Shared Neighborhood Hits	251
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANR10_HUMAN
θ value	3.19293e-05 (rank : 151)	NC score	0.654281 (rank : 78)
Query Neighborhood Hits	467	Target Neighborhood Hits	289	Shared Neighborhood Hits	238
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

HECD1_HUMAN
θ value	3.19293e-05 (rank : 152)	NC score	0.491562 (rank : 203)
Query Neighborhood Hits	467	Target Neighborhood Hits	371	Shared Neighborhood Hits	244
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

PA2G6_MOUSE
θ value	3.19293e-05 (rank : 153)	NC score	0.649509 (rank : 90)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	249
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

GRAP_HUMAN
θ value	4.1701e-05 (rank : 154)	NC score	0.463490 (rank : 235)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	208
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

MIB2_MOUSE
θ value	4.1701e-05 (rank : 155)	NC score	0.640338 (rank : 102)
Query Neighborhood Hits	467	Target Neighborhood Hits	409	Shared Neighborhood Hits	251
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

ASB13_HUMAN
θ value	5.44631e-05 (rank : 156)	NC score	0.665957 (rank : 46)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	252
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB13_MOUSE
θ value	5.44631e-05 (rank : 157)	NC score	0.666581 (rank : 44)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

FUT8_HUMAN
θ value	5.44631e-05 (rank : 158)	NC score	0.153217 (rank : 458)
Query Neighborhood Hits	467	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

NEBL_HUMAN
θ value	5.44631e-05 (rank : 159)	NC score	0.347425 (rank : 316)
Query Neighborhood Hits	467	Target Neighborhood Hits	457	Shared Neighborhood Hits	167
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

A20A1_HUMAN
θ value	7.1131e-05 (rank : 160)	NC score	0.527164 (rank : 190)
Query Neighborhood Hits	467	Target Neighborhood Hits	698	Shared Neighborhood Hits	250
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A2_HUMAN
θ value	7.1131e-05 (rank : 161)	NC score	0.526913 (rank : 191)
Query Neighborhood Hits	467	Target Neighborhood Hits	716	Shared Neighborhood Hits	251
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A3_HUMAN
θ value	7.1131e-05 (rank : 162)	NC score	0.528349 (rank : 189)
Query Neighborhood Hits	467	Target Neighborhood Hits	692	Shared Neighborhood Hits	253
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	7.1131e-05 (rank : 163)	NC score	0.525076 (rank : 192)
Query Neighborhood Hits	467	Target Neighborhood Hits	710	Shared Neighborhood Hits	254
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

ANR49_MOUSE
θ value	7.1131e-05 (rank : 164)	NC score	0.681981 (rank : 21)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

GABP3_MOUSE
θ value	7.1131e-05 (rank : 165)	NC score	0.668323 (rank : 41)
Query Neighborhood Hits	467	Target Neighborhood Hits	330	Shared Neighborhood Hits	254
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

MTPN_HUMAN
θ value	7.1131e-05 (rank : 166)	NC score	0.681148 (rank : 22)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	241
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

NEBU_HUMAN
θ value	7.1131e-05 (rank : 167)	NC score	0.306305 (rank : 346)
Query Neighborhood Hits	467	Target Neighborhood Hits	420	Shared Neighborhood Hits	164
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NUD12_MOUSE
θ value	7.1131e-05 (rank : 168)	NC score	0.504387 (rank : 196)
Query Neighborhood Hits	467	Target Neighborhood Hits	243	Shared Neighborhood Hits	212
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

PP16A_HUMAN
θ value	7.1131e-05 (rank : 169)	NC score	0.656995 (rank : 69)
Query Neighborhood Hits	467	Target Neighborhood Hits	340	Shared Neighborhood Hits	250
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ANRA2_HUMAN
θ value	9.29e-05 (rank : 170)	NC score	0.662428 (rank : 55)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	250
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB5_MOUSE
θ value	9.29e-05 (rank : 171)	NC score	0.644861 (rank : 96)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	235
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

SRBS1_HUMAN
θ value	9.29e-05 (rank : 172)	NC score	0.458612 (rank : 242)
Query Neighborhood Hits	467	Target Neighborhood Hits	396	Shared Neighborhood Hits	201
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC_MOUSE
θ value	9.29e-05 (rank : 173)	NC score	0.169175 (rank : 434)
Query Neighborhood Hits	467	Target Neighborhood Hits	1033	Shared Neighborhood Hits	176
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TEX14_HUMAN
θ value	9.29e-05 (rank : 174)	NC score	0.394457 (rank : 284)
Query Neighborhood Hits	467	Target Neighborhood Hits	1103	Shared Neighborhood Hits	256
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TXK_MOUSE
θ value	9.29e-05 (rank : 175)	NC score	0.153419 (rank : 457)
Query Neighborhood Hits	467	Target Neighborhood Hits	980	Shared Neighborhood Hits	160
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ANRA2_MOUSE
θ value	0.000121331 (rank : 176)	NC score	0.659878 (rank : 61)
Query Neighborhood Hits	467	Target Neighborhood Hits	287	Shared Neighborhood Hits	248
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

MPP8_HUMAN
θ value	0.000121331 (rank : 177)	NC score	0.535482 (rank : 183)
Query Neighborhood Hits	467	Target Neighborhood Hits	948	Shared Neighborhood Hits	243
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

NCK1_HUMAN
θ value	0.000121331 (rank : 178)	NC score	0.448185 (rank : 252)
Query Neighborhood Hits	467	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SPTA1_HUMAN
θ value	0.000121331 (rank : 179)	NC score	0.188967 (rank : 419)
Query Neighborhood Hits	467	Target Neighborhood Hits	748	Shared Neighborhood Hits	169
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VAV2_HUMAN
θ value	0.000121331 (rank : 180)	NC score	0.337472 (rank : 324)
Query Neighborhood Hits	467	Target Neighborhood Hits	453	Shared Neighborhood Hits	173
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.000121331 (rank : 181)	NC score	0.337025 (rank : 326)
Query Neighborhood Hits	467	Target Neighborhood Hits	456	Shared Neighborhood Hits	174
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ANKS6_MOUSE
θ value	0.000158464 (rank : 182)	NC score	0.655234 (rank : 75)
Query Neighborhood Hits	467	Target Neighborhood Hits	435	Shared Neighborhood Hits	258
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANR16_HUMAN
θ value	0.000158464 (rank : 183)	NC score	0.679701 (rank : 24)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	254
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR32_MOUSE
θ value	0.000158464 (rank : 184)	NC score	0.627114 (rank : 112)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	236
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR33_HUMAN
θ value	0.000158464 (rank : 185)	NC score	0.561453 (rank : 172)
Query Neighborhood Hits	467	Target Neighborhood Hits	215	Shared Neighborhood Hits	200
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

DDEF2_HUMAN
θ value	0.000158464 (rank : 186)	NC score	0.467604 (rank : 230)
Query Neighborhood Hits	467	Target Neighborhood Hits	599	Shared Neighborhood Hits	347
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.000158464 (rank : 187)	NC score	0.466940 (rank : 231)
Query Neighborhood Hits	467	Target Neighborhood Hits	625	Shared Neighborhood Hits	349
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

LASP1_HUMAN
θ value	0.000158464 (rank : 188)	NC score	0.362737 (rank : 306)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	156
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.000158464 (rank : 189)	NC score	0.361096 (rank : 309)
Query Neighborhood Hits	467	Target Neighborhood Hits	297	Shared Neighborhood Hits	154
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NOTC4_HUMAN
θ value	0.000158464 (rank : 190)	NC score	0.337868 (rank : 323)
Query Neighborhood Hits	467	Target Neighborhood Hits	905	Shared Neighborhood Hits	252
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

RFXK_MOUSE
θ value	0.000158464 (rank : 191)	NC score	0.648763 (rank : 93)
Query Neighborhood Hits	467	Target Neighborhood Hits	273	Shared Neighborhood Hits	243
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

RHG04_HUMAN
θ value	0.000158464 (rank : 192)	NC score	0.257415 (rank : 370)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	169
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRBS1_MOUSE
θ value	0.000158464 (rank : 193)	NC score	0.459002 (rank : 241)
Query Neighborhood Hits	467	Target Neighborhood Hits	409	Shared Neighborhood Hits	199
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC3_HUMAN
θ value	0.000158464 (rank : 194)	NC score	0.403444 (rank : 272)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	154
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

UACA_HUMAN
θ value	0.000158464 (rank : 195)	NC score	0.395099 (rank : 281)
Query Neighborhood Hits	467	Target Neighborhood Hits	1622	Shared Neighborhood Hits	271
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

UACA_MOUSE
θ value	0.000158464 (rank : 196)	NC score	0.376829 (rank : 297)
Query Neighborhood Hits	467	Target Neighborhood Hits	1620	Shared Neighborhood Hits	276
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

VAV_HUMAN
θ value	0.000158464 (rank : 197)	NC score	0.357183 (rank : 311)
Query Neighborhood Hits	467	Target Neighborhood Hits	452	Shared Neighborhood Hits	182
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_MOUSE
θ value	0.00020696 (rank : 198)	NC score	0.314661 (rank : 341)
Query Neighborhood Hits	467	Target Neighborhood Hits	496	Shared Neighborhood Hits	190
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANR35_HUMAN
θ value	0.00020696 (rank : 199)	NC score	0.613381 (rank : 132)
Query Neighborhood Hits	467	Target Neighborhood Hits	784	Shared Neighborhood Hits	262
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

ANR49_HUMAN
θ value	0.00020696 (rank : 200)	NC score	0.677532 (rank : 27)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

CRKL_HUMAN
θ value	0.00020696 (rank : 201)	NC score	0.417146 (rank : 266)
Query Neighborhood Hits	467	Target Neighborhood Hits	313	Shared Neighborhood Hits	199
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NOTC4_MOUSE
θ value	0.00020696 (rank : 202)	NC score	0.342710 (rank : 319)
Query Neighborhood Hits	467	Target Neighborhood Hits	872	Shared Neighborhood Hits	253
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ANKY2_HUMAN
θ value	0.000270298 (rank : 203)	NC score	0.603764 (rank : 138)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR26_MOUSE
θ value	0.000270298 (rank : 204)	NC score	0.368094 (rank : 301)
Query Neighborhood Hits	467	Target Neighborhood Hits	1554	Shared Neighborhood Hits	267
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

DNMBP_MOUSE
θ value	0.000270298 (rank : 205)	NC score	0.388949 (rank : 288)
Query Neighborhood Hits	467	Target Neighborhood Hits	435	Shared Neighborhood Hits	194
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PPIP1_HUMAN
θ value	0.000270298 (rank : 206)	NC score	0.403137 (rank : 273)
Query Neighborhood Hits	467	Target Neighborhood Hits	389	Shared Neighborhood Hits	197
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

USH1G_HUMAN
θ value	0.000270298 (rank : 207)	NC score	0.613542 (rank : 129)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	242
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	0.000270298 (rank : 208)	NC score	0.613442 (rank : 131)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	242
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANKY2_MOUSE
θ value	0.00035302 (rank : 209)	NC score	0.580134 (rank : 159)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	234
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR26_HUMAN
θ value	0.00035302 (rank : 210)	NC score	0.354666 (rank : 312)
Query Neighborhood Hits	467	Target Neighborhood Hits	1614	Shared Neighborhood Hits	267
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANR33_MOUSE
θ value	0.00035302 (rank : 211)	NC score	0.563244 (rank : 171)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ASB15_HUMAN
θ value	0.00035302 (rank : 212)	NC score	0.636043 (rank : 106)
Query Neighborhood Hits	467	Target Neighborhood Hits	305	Shared Neighborhood Hits	248
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

BCOR_MOUSE
θ value	0.00035302 (rank : 213)	NC score	0.587945 (rank : 155)
Query Neighborhood Hits	467	Target Neighborhood Hits	521	Shared Neighborhood Hits	247
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

PA2G6_HUMAN
θ value	0.00035302 (rank : 214)	NC score	0.640991 (rank : 101)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	247
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

SHAN1_HUMAN
θ value	0.00035302 (rank : 215)	NC score	0.665546 (rank : 47)
Query Neighborhood Hits	467	Target Neighborhood Hits	1041	Shared Neighborhood Hits	370
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

VAV3_HUMAN
θ value	0.00035302 (rank : 216)	NC score	0.328703 (rank : 331)
Query Neighborhood Hits	467	Target Neighborhood Hits	398	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BCOR_HUMAN
θ value	0.000461057 (rank : 217)	NC score	0.581802 (rank : 157)
Query Neighborhood Hits	467	Target Neighborhood Hits	609	Shared Neighborhood Hits	252
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CRKL_MOUSE
θ value	0.000461057 (rank : 218)	NC score	0.411326 (rank : 269)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	197
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

M3K11_HUMAN
θ value	0.000461057 (rank : 219)	NC score	0.164310 (rank : 440)
Query Neighborhood Hits	467	Target Neighborhood Hits	1136	Shared Neighborhood Hits	192
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NCK2_HUMAN
θ value	0.000461057 (rank : 220)	NC score	0.439919 (rank : 258)
Query Neighborhood Hits	467	Target Neighborhood Hits	310	Shared Neighborhood Hits	186
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PP16B_HUMAN
θ value	0.000461057 (rank : 221)	NC score	0.649577 (rank : 89)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	254
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

PP16B_MOUSE
θ value	0.000461057 (rank : 222)	NC score	0.648923 (rank : 91)
Query Neighborhood Hits	467	Target Neighborhood Hits	302	Shared Neighborhood Hits	252
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ABTB1_MOUSE
θ value	0.000602161 (rank : 223)	NC score	0.296372 (rank : 354)
Query Neighborhood Hits	467	Target Neighborhood Hits	349	Shared Neighborhood Hits	172
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ANR47_MOUSE
θ value	0.000602161 (rank : 224)	NC score	0.582028 (rank : 156)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	237
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

M3KL4_HUMAN
θ value	0.000602161 (rank : 225)	NC score	0.173119 (rank : 428)
Query Neighborhood Hits	467	Target Neighborhood Hits	1087	Shared Neighborhood Hits	190
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

VAV3_MOUSE
θ value	0.000602161 (rank : 226)	NC score	0.323316 (rank : 336)
Query Neighborhood Hits	467	Target Neighborhood Hits	404	Shared Neighborhood Hits	175
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FANK1_HUMAN
θ value	0.000786445 (rank : 227)	NC score	0.673311 (rank : 34)
Query Neighborhood Hits	467	Target Neighborhood Hits	326	Shared Neighborhood Hits	252
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

RN5A_MOUSE
θ value	0.000786445 (rank : 228)	NC score	0.601357 (rank : 141)
Query Neighborhood Hits	467	Target Neighborhood Hits	899	Shared Neighborhood Hits	276
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

STAC3_MOUSE
θ value	0.000786445 (rank : 229)	NC score	0.401621 (rank : 277)
Query Neighborhood Hits	467	Target Neighborhood Hits	232	Shared Neighborhood Hits	155
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ANFY1_MOUSE
θ value	0.00102713 (rank : 230)	NC score	0.581359 (rank : 158)
Query Neighborhood Hits	467	Target Neighborhood Hits	480	Shared Neighborhood Hits	254
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANR32_HUMAN
θ value	0.00102713 (rank : 231)	NC score	0.631298 (rank : 111)
Query Neighborhood Hits	467	Target Neighborhood Hits	270	Shared Neighborhood Hits	235
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

FRK_HUMAN
θ value	0.00102713 (rank : 232)	NC score	0.161791 (rank : 443)
Query Neighborhood Hits	467	Target Neighborhood Hits	1058	Shared Neighborhood Hits	200
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FUT8_MOUSE
θ value	0.00102713 (rank : 233)	NC score	0.141525 (rank : 479)
Query Neighborhood Hits	467	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

NFKB2_HUMAN
θ value	0.00102713 (rank : 234)	NC score	0.540407 (rank : 181)
Query Neighborhood Hits	467	Target Neighborhood Hits	325	Shared Neighborhood Hits	246
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

TXK_HUMAN
θ value	0.00102713 (rank : 235)	NC score	0.145205 (rank : 472)
Query Neighborhood Hits	467	Target Neighborhood Hits	971	Shared Neighborhood Hits	143
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ABTB1_HUMAN
θ value	0.00134147 (rank : 236)	NC score	0.261362 (rank : 368)
Query Neighborhood Hits	467	Target Neighborhood Hits	325	Shared Neighborhood Hits	157
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

FANK1_MOUSE
θ value	0.00134147 (rank : 237)	NC score	0.675306 (rank : 30)
Query Neighborhood Hits	467	Target Neighborhood Hits	325	Shared Neighborhood Hits	253
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

IKBB_MOUSE
θ value	0.00134147 (rank : 238)	NC score	0.594108 (rank : 146)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	243
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

RIMB1_MOUSE
θ value	0.00134147 (rank : 239)	NC score	0.164000 (rank : 442)
Query Neighborhood Hits	467	Target Neighborhood Hits	1376	Shared Neighborhood Hits	177
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

AHI1_HUMAN
θ value	0.00175202 (rank : 240)	NC score	0.318185 (rank : 339)
Query Neighborhood Hits	467	Target Neighborhood Hits	537	Shared Neighborhood Hits	190
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ANR37_HUMAN
θ value	0.00175202 (rank : 241)	NC score	0.603596 (rank : 139)
Query Neighborhood Hits	467	Target Neighborhood Hits	247	Shared Neighborhood Hits	227
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ASB3_MOUSE
θ value	0.00175202 (rank : 242)	NC score	0.663233 (rank : 54)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	256
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

CRK_HUMAN
θ value	0.00175202 (rank : 243)	NC score	0.400372 (rank : 278)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	205
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.00175202 (rank : 244)	NC score	0.401681 (rank : 276)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	203
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DGKZ_HUMAN
θ value	0.00175202 (rank : 245)	NC score	0.326272 (rank : 333)
Query Neighborhood Hits	467	Target Neighborhood Hits	551	Shared Neighborhood Hits	206
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

LCK_HUMAN
θ value	0.00175202 (rank : 246)	NC score	0.148440 (rank : 465)
Query Neighborhood Hits	467	Target Neighborhood Hits	987	Shared Neighborhood Hits	136
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

PACN2_MOUSE
θ value	0.00175202 (rank : 247)	NC score	0.378071 (rank : 296)
Query Neighborhood Hits	467	Target Neighborhood Hits	382	Shared Neighborhood Hits	190
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

TCGAP_HUMAN
θ value	0.00175202 (rank : 248)	NC score	0.164024 (rank : 441)
Query Neighborhood Hits	467	Target Neighborhood Hits	872	Shared Neighborhood Hits	134
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	0.00175202 (rank : 249)	NC score	0.178976 (rank : 424)
Query Neighborhood Hits	467	Target Neighborhood Hits	409	Shared Neighborhood Hits	125
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ASB15_MOUSE
θ value	0.00228821 (rank : 250)	NC score	0.626592 (rank : 114)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	245
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

CENB5_HUMAN
θ value	0.00228821 (rank : 251)	NC score	0.432549 (rank : 260)
Query Neighborhood Hits	467	Target Neighborhood Hits	395	Shared Neighborhood Hits	235
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

LCK_MOUSE
θ value	0.00228821 (rank : 252)	NC score	0.147382 (rank : 468)
Query Neighborhood Hits	467	Target Neighborhood Hits	981	Shared Neighborhood Hits	134
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

NCF4_MOUSE
θ value	0.00228821 (rank : 253)	NC score	0.415562 (rank : 267)
Query Neighborhood Hits	467	Target Neighborhood Hits	177	Shared Neighborhood Hits	143
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

POT14_HUMAN
θ value	0.00228821 (rank : 254)	NC score	0.564325 (rank : 168)
Query Neighborhood Hits	467	Target Neighborhood Hits	403	Shared Neighborhood Hits	245
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

PTK6_MOUSE
θ value	0.00228821 (rank : 255)	NC score	0.146571 (rank : 470)
Query Neighborhood Hits	467	Target Neighborhood Hits	1026	Shared Neighborhood Hits	175
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RIMB1_HUMAN
θ value	0.00228821 (rank : 256)	NC score	0.172341 (rank : 430)
Query Neighborhood Hits	467	Target Neighborhood Hits	1479	Shared Neighborhood Hits	160
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

AN36B_HUMAN
θ value	0.00298849 (rank : 257)	NC score	0.623228 (rank : 116)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	246
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ASB16_HUMAN
θ value	0.00298849 (rank : 258)	NC score	0.635138 (rank : 107)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	241
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB8_HUMAN
θ value	0.00298849 (rank : 259)	NC score	0.657367 (rank : 68)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	250
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

BCL3_MOUSE
θ value	0.00298849 (rank : 260)	NC score	0.637907 (rank : 103)
Query Neighborhood Hits	467	Target Neighborhood Hits	388	Shared Neighborhood Hits	250
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

ES8L3_HUMAN
θ value	0.00298849 (rank : 261)	NC score	0.233574 (rank : 387)
Query Neighborhood Hits	467	Target Neighborhood Hits	206	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NCF1_HUMAN
θ value	0.00298849 (rank : 262)	NC score	0.394954 (rank : 282)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	159
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF4_HUMAN
θ value	0.00298849 (rank : 263)	NC score	0.394944 (rank : 283)
Query Neighborhood Hits	467	Target Neighborhood Hits	161	Shared Neighborhood Hits	129
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

POT22_HUMAN
θ value	0.00298849 (rank : 264)	NC score	0.534682 (rank : 186)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	234
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

RN5A_HUMAN
θ value	0.00298849 (rank : 265)	NC score	0.626587 (rank : 115)
Query Neighborhood Hits	467	Target Neighborhood Hits	608	Shared Neighborhood Hits	266
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ASB3_HUMAN
θ value	0.00390308 (rank : 266)	NC score	0.661906 (rank : 56)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB4_MOUSE
θ value	0.00390308 (rank : 267)	NC score	0.620978 (rank : 120)
Query Neighborhood Hits	467	Target Neighborhood Hits	265	Shared Neighborhood Hits	232
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASPP1_HUMAN
θ value	0.00390308 (rank : 268)	NC score	0.614327 (rank : 128)
Query Neighborhood Hits	467	Target Neighborhood Hits	956	Shared Neighborhood Hits	381
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCL3_HUMAN
θ value	0.00390308 (rank : 269)	NC score	0.641019 (rank : 100)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	249
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

CT032_HUMAN
θ value	0.00390308 (rank : 270)	NC score	0.336111 (rank : 327)
Query Neighborhood Hits	467	Target Neighborhood Hits	235	Shared Neighborhood Hits	140
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DGKZ_MOUSE
θ value	0.00390308 (rank : 271)	NC score	0.306181 (rank : 347)
Query Neighborhood Hits	467	Target Neighborhood Hits	542	Shared Neighborhood Hits	192
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

ES8L3_MOUSE
θ value	0.00390308 (rank : 272)	NC score	0.248612 (rank : 372)
Query Neighborhood Hits	467	Target Neighborhood Hits	168	Shared Neighborhood Hits	136
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PLCG1_MOUSE
θ value	0.00390308 (rank : 273)	NC score	0.307700 (rank : 343)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	159
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ANS4B_HUMAN
θ value	0.00509761 (rank : 274)	NC score	0.608967 (rank : 135)
Query Neighborhood Hits	467	Target Neighborhood Hits	289	Shared Neighborhood Hits	242
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB7_HUMAN
θ value	0.00509761 (rank : 275)	NC score	0.655146 (rank : 76)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	250
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
θ value	0.00509761 (rank : 276)	NC score	0.655441 (rank : 74)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	250
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASPP1_MOUSE
θ value	0.00509761 (rank : 277)	NC score	0.598813 (rank : 144)
Query Neighborhood Hits	467	Target Neighborhood Hits	1244	Shared Neighborhood Hits	387
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CASL_HUMAN
θ value	0.00509761 (rank : 278)	NC score	0.283703 (rank : 360)
Query Neighborhood Hits	467	Target Neighborhood Hits	259	Shared Neighborhood Hits	149
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NUD12_HUMAN
θ value	0.00509761 (rank : 279)	NC score	0.475361 (rank : 220)
Query Neighborhood Hits	467	Target Neighborhood Hits	222	Shared Neighborhood Hits	196
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

PACN2_HUMAN
θ value	0.00509761 (rank : 280)	NC score	0.381198 (rank : 294)
Query Neighborhood Hits	467	Target Neighborhood Hits	339	Shared Neighborhood Hits	187
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

POT15_HUMAN
θ value	0.00509761 (rank : 281)	NC score	0.564102 (rank : 169)
Query Neighborhood Hits	467	Target Neighborhood Hits	893	Shared Neighborhood Hits	257
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

STS1_MOUSE
θ value	0.00509761 (rank : 282)	NC score	0.178771 (rank : 425)
Query Neighborhood Hits	467	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

AN36A_HUMAN
θ value	0.00665767 (rank : 283)	NC score	0.608369 (rank : 136)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	239
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANFY1_HUMAN
θ value	0.00665767 (rank : 284)	NC score	0.578820 (rank : 161)
Query Neighborhood Hits	467	Target Neighborhood Hits	480	Shared Neighborhood Hits	254
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANR42_MOUSE
θ value	0.00665767 (rank : 285)	NC score	0.663471 (rank : 52)
Query Neighborhood Hits	467	Target Neighborhood Hits	334	Shared Neighborhood Hits	253
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASZ1_HUMAN
θ value	0.00665767 (rank : 286)	NC score	0.648778 (rank : 92)
Query Neighborhood Hits	467	Target Neighborhood Hits	341	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

CASL_MOUSE
θ value	0.00665767 (rank : 287)	NC score	0.286003 (rank : 359)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	146
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

DDFL1_MOUSE
θ value	0.00665767 (rank : 288)	NC score	0.384924 (rank : 292)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	229
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

NCF1_MOUSE
θ value	0.00665767 (rank : 289)	NC score	0.387317 (rank : 290)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	161
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PPIP1_MOUSE
θ value	0.00665767 (rank : 290)	NC score	0.399830 (rank : 279)
Query Neighborhood Hits	467	Target Neighborhood Hits	377	Shared Neighborhood Hits	196
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

STS1_HUMAN
θ value	0.00665767 (rank : 291)	NC score	0.177338 (rank : 426)
Query Neighborhood Hits	467	Target Neighborhood Hits	106	Shared Neighborhood Hits	74
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ANS4B_MOUSE
θ value	0.00869519 (rank : 292)	NC score	0.598999 (rank : 143)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	240
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB8_MOUSE
θ value	0.00869519 (rank : 293)	NC score	0.656536 (rank : 72)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	250
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

BCAR1_HUMAN
θ value	0.00869519 (rank : 294)	NC score	0.298388 (rank : 353)
Query Neighborhood Hits	467	Target Neighborhood Hits	554	Shared Neighborhood Hits	173
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CT086_HUMAN
θ value	0.00869519 (rank : 295)	NC score	0.641170 (rank : 99)
Query Neighborhood Hits	467	Target Neighborhood Hits	277	Shared Neighborhood Hits	244
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

IKBE_MOUSE
θ value	0.00869519 (rank : 296)	NC score	0.612077 (rank : 133)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	245
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

M3K9_HUMAN
θ value	0.00869519 (rank : 297)	NC score	0.157898 (rank : 448)
Query Neighborhood Hits	467	Target Neighborhood Hits	1123	Shared Neighborhood Hits	188
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ANR37_MOUSE
θ value	0.0113563 (rank : 298)	NC score	0.578881 (rank : 160)
Query Neighborhood Hits	467	Target Neighborhood Hits	237	Shared Neighborhood Hits	218
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR38_HUMAN
θ value	0.0113563 (rank : 299)	NC score	0.539508 (rank : 182)
Query Neighborhood Hits	467	Target Neighborhood Hits	443	Shared Neighborhood Hits	230
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ANR38_MOUSE
θ value	0.0113563 (rank : 300)	NC score	0.519219 (rank : 194)
Query Neighborhood Hits	467	Target Neighborhood Hits	512	Shared Neighborhood Hits	226
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ASB1_HUMAN
θ value	0.0113563 (rank : 301)	NC score	0.620606 (rank : 121)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	246
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ASPP2_HUMAN
θ value	0.0113563 (rank : 302)	NC score	0.590460 (rank : 153)
Query Neighborhood Hits	467	Target Neighborhood Hits	1156	Shared Neighborhood Hits	380
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCAR1_MOUSE
θ value	0.0113563 (rank : 303)	NC score	0.304737 (rank : 348)
Query Neighborhood Hits	467	Target Neighborhood Hits	438	Shared Neighborhood Hits	170
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DDEF1_MOUSE
θ value	0.0113563 (rank : 304)	NC score	0.404883 (rank : 270)
Query Neighborhood Hits	467	Target Neighborhood Hits	592	Shared Neighborhood Hits	301
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FNBP2_HUMAN
θ value	0.0113563 (rank : 305)	NC score	0.217213 (rank : 393)
Query Neighborhood Hits	467	Target Neighborhood Hits	432	Shared Neighborhood Hits	149
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

IKBB_HUMAN
θ value	0.0113563 (rank : 306)	NC score	0.592654 (rank : 148)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	244
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

LYN_MOUSE
θ value	0.0113563 (rank : 307)	NC score	0.157675 (rank : 450)
Query Neighborhood Hits	467	Target Neighborhood Hits	1023	Shared Neighborhood Hits	168
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PLCG1_HUMAN
θ value	0.0113563 (rank : 308)	NC score	0.295029 (rank : 356)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	152
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SPN90_MOUSE
θ value	0.0113563 (rank : 309)	NC score	0.216633 (rank : 394)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA1_MOUSE
θ value	0.0113563 (rank : 310)	NC score	0.188301 (rank : 422)
Query Neighborhood Hits	467	Target Neighborhood Hits	675	Shared Neighborhood Hits	159
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP2_HUMAN
θ value	0.0113563 (rank : 311)	NC score	0.227512 (rank : 391)
Query Neighborhood Hits	467	Target Neighborhood Hits	331	Shared Neighborhood Hits	149
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	0.0113563 (rank : 312)	NC score	0.230259 (rank : 389)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	153
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ANR21_HUMAN
θ value	0.0148317 (rank : 313)	NC score	0.563630 (rank : 170)
Query Neighborhood Hits	467	Target Neighborhood Hits	864	Shared Neighborhood Hits	257
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

MPP4_HUMAN
θ value	0.0148317 (rank : 314)	NC score	0.116132 (rank : 515)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	70
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NFKB1_HUMAN
θ value	0.0148317 (rank : 315)	NC score	0.544600 (rank : 178)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	246
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

TEC_HUMAN
θ value	0.0148317 (rank : 316)	NC score	0.147490 (rank : 467)
Query Neighborhood Hits	467	Target Neighborhood Hits	1006	Shared Neighborhood Hits	154
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ASB4_HUMAN
θ value	0.0193708 (rank : 317)	NC score	0.620083 (rank : 122)
Query Neighborhood Hits	467	Target Neighborhood Hits	264	Shared Neighborhood Hits	232
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

CLPB_MOUSE
θ value	0.0193708 (rank : 318)	NC score	0.534763 (rank : 185)
Query Neighborhood Hits	467	Target Neighborhood Hits	289	Shared Neighborhood Hits	229
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

HCK_MOUSE
θ value	0.0193708 (rank : 319)	NC score	0.167650 (rank : 436)
Query Neighborhood Hits	467	Target Neighborhood Hits	1029	Shared Neighborhood Hits	181
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

RHG26_HUMAN
θ value	0.0193708 (rank : 320)	NC score	0.212709 (rank : 398)
Query Neighborhood Hits	467	Target Neighborhood Hits	281	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TEC_MOUSE
θ value	0.0193708 (rank : 321)	NC score	0.144091 (rank : 475)
Query Neighborhood Hits	467	Target Neighborhood Hits	1006	Shared Neighborhood Hits	154
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ABI3_HUMAN
θ value	0.0252991 (rank : 322)	NC score	0.379361 (rank : 295)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANR45_HUMAN
θ value	0.0252991 (rank : 323)	NC score	0.479191 (rank : 212)
Query Neighborhood Hits	467	Target Neighborhood Hits	201	Shared Neighborhood Hits	177
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ARHG5_HUMAN
θ value	0.0252991 (rank : 324)	NC score	0.165487 (rank : 439)
Query Neighborhood Hits	467	Target Neighborhood Hits	172	Shared Neighborhood Hits	91
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ASB14_MOUSE
θ value	0.0252991 (rank : 325)	NC score	0.619580 (rank : 123)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	249
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

CDN2B_HUMAN
θ value	0.0252991 (rank : 326)	NC score	0.471988 (rank : 226)
Query Neighborhood Hits	467	Target Neighborhood Hits	196	Shared Neighborhood Hits	184
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

CENB2_HUMAN
θ value	0.0252991 (rank : 327)	NC score	0.423635 (rank : 263)
Query Neighborhood Hits	467	Target Neighborhood Hits	425	Shared Neighborhood Hits	230
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

DBNL_HUMAN
θ value	0.0252991 (rank : 328)	NC score	0.364314 (rank : 304)
Query Neighborhood Hits	467	Target Neighborhood Hits	244	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0252991 (rank : 329)	NC score	0.362210 (rank : 308)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	154
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ITK_HUMAN
θ value	0.0252991 (rank : 330)	NC score	0.140091 (rank : 482)
Query Neighborhood Hits	467	Target Neighborhood Hits	1016	Shared Neighborhood Hits	146
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	0.0252991 (rank : 331)	NC score	0.134560 (rank : 487)
Query Neighborhood Hits	467	Target Neighborhood Hits	985	Shared Neighborhood Hits	133
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

NOTC1_MOUSE
θ value	0.0252991 (rank : 332)	NC score	0.252588 (rank : 371)
Query Neighborhood Hits	467	Target Neighborhood Hits	916	Shared Neighborhood Hits	239
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

SPN90_HUMAN
θ value	0.0252991 (rank : 333)	NC score	0.237119 (rank : 385)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ARHG4_HUMAN
θ value	0.0330416 (rank : 334)	NC score	0.291163 (rank : 358)
Query Neighborhood Hits	467	Target Neighborhood Hits	242	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

LYN_HUMAN
θ value	0.0330416 (rank : 335)	NC score	0.157867 (rank : 449)
Query Neighborhood Hits	467	Target Neighborhood Hits	1022	Shared Neighborhood Hits	167
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	0.0330416 (rank : 336)	NC score	0.148754 (rank : 463)
Query Neighborhood Hits	467	Target Neighborhood Hits	1071	Shared Neighborhood Hits	176
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

NFKB2_MOUSE
θ value	0.0330416 (rank : 337)	NC score	0.524720 (rank : 193)
Query Neighborhood Hits	467	Target Neighborhood Hits	326	Shared Neighborhood Hits	241
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

NOTC1_HUMAN
θ value	0.0330416 (rank : 338)	NC score	0.299474 (rank : 351)
Query Neighborhood Hits	467	Target Neighborhood Hits	906	Shared Neighborhood Hits	249
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOXO1_MOUSE
θ value	0.0330416 (rank : 339)	NC score	0.263909 (rank : 367)
Query Neighborhood Hits	467	Target Neighborhood Hits	114	Shared Neighborhood Hits	101
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN3_MOUSE
θ value	0.0330416 (rank : 340)	NC score	0.342304 (rank : 320)
Query Neighborhood Hits	467	Target Neighborhood Hits	380	Shared Neighborhood Hits	173
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PLCG2_HUMAN
θ value	0.0330416 (rank : 341)	NC score	0.299659 (rank : 350)
Query Neighborhood Hits	467	Target Neighborhood Hits	280	Shared Neighborhood Hits	153
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PTK6_HUMAN
θ value	0.0330416 (rank : 342)	NC score	0.142928 (rank : 476)
Query Neighborhood Hits	467	Target Neighborhood Hits	1020	Shared Neighborhood Hits	178
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RIMB2_HUMAN
θ value	0.0330416 (rank : 343)	NC score	0.264728 (rank : 366)
Query Neighborhood Hits	467	Target Neighborhood Hits	263	Shared Neighborhood Hits	122
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	0.0330416 (rank : 344)	NC score	0.258229 (rank : 369)
Query Neighborhood Hits	467	Target Neighborhood Hits	246	Shared Neighborhood Hits	114
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ASB12_HUMAN
θ value	0.0431538 (rank : 345)	NC score	0.614667 (rank : 127)
Query Neighborhood Hits	467	Target Neighborhood Hits	263	Shared Neighborhood Hits	239
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

CSK_HUMAN
θ value	0.0431538 (rank : 346)	NC score	0.144750 (rank : 473)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	153
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.0431538 (rank : 347)	NC score	0.144499 (rank : 474)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	153
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

NOTC3_HUMAN
θ value	0.0431538 (rank : 348)	NC score	0.299119 (rank : 352)
Query Neighborhood Hits	467	Target Neighborhood Hits	1062	Shared Neighborhood Hits	248
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	0.0431538 (rank : 349)	NC score	0.301826 (rank : 349)
Query Neighborhood Hits	467	Target Neighborhood Hits	975	Shared Neighborhood Hits	251
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ASZ1_MOUSE
θ value	0.0563607 (rank : 350)	NC score	0.646586 (rank : 95)
Query Neighborhood Hits	467	Target Neighborhood Hits	319	Shared Neighborhood Hits	249
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

EM55_HUMAN
θ value	0.0563607 (rank : 351)	NC score	0.154205 (rank : 454)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	105
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

IKBA_HUMAN
θ value	0.0563607 (rank : 352)	NC score	0.613499 (rank : 130)
Query Neighborhood Hits	467	Target Neighborhood Hits	280	Shared Neighborhood Hits	239
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

PACN3_HUMAN
θ value	0.0563607 (rank : 353)	NC score	0.340112 (rank : 321)
Query Neighborhood Hits	467	Target Neighborhood Hits	385	Shared Neighborhood Hits	170
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ANKR7_HUMAN
θ value	0.0736092 (rank : 354)	NC score	0.631385 (rank : 110)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	249
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANR47_HUMAN
θ value	0.0736092 (rank : 355)	NC score	0.558566 (rank : 174)
Query Neighborhood Hits	467	Target Neighborhood Hits	369	Shared Neighborhood Hits	233
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB16_MOUSE
θ value	0.0736092 (rank : 356)	NC score	0.632440 (rank : 109)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	247
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB1_MOUSE
θ value	0.0736092 (rank : 357)	NC score	0.617776 (rank : 124)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	246
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

CSKP_MOUSE
θ value	0.0736092 (rank : 358)	NC score	0.075532 (rank : 678)
Query Neighborhood Hits	467	Target Neighborhood Hits	1027	Shared Neighborhood Hits	148
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

HCK_HUMAN
θ value	0.0736092 (rank : 359)	NC score	0.166011 (rank : 438)
Query Neighborhood Hits	467	Target Neighborhood Hits	1035	Shared Neighborhood Hits	183
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

PACN1_HUMAN
θ value	0.0736092 (rank : 360)	NC score	0.362610 (rank : 307)
Query Neighborhood Hits	467	Target Neighborhood Hits	320	Shared Neighborhood Hits	179
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.0736092 (rank : 361)	NC score	0.363606 (rank : 305)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	178
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SNCAP_HUMAN
θ value	0.0736092 (rank : 362)	NC score	0.553137 (rank : 176)
Query Neighborhood Hits	467	Target Neighborhood Hits	313	Shared Neighborhood Hits	219
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ANM2_MOUSE
θ value	0.0961366 (rank : 363)	NC score	0.228613 (rank : 390)
Query Neighborhood Hits	467	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANR45_MOUSE
θ value	0.0961366 (rank : 364)	NC score	0.502011 (rank : 198)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	179
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ASB6_HUMAN
θ value	0.0961366 (rank : 365)	NC score	0.552059 (rank : 177)
Query Neighborhood Hits	467	Target Neighborhood Hits	256	Shared Neighborhood Hits	219
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

EM55_MOUSE
θ value	0.0961366 (rank : 366)	NC score	0.149960 (rank : 460)
Query Neighborhood Hits	467	Target Neighborhood Hits	221	Shared Neighborhood Hits	101
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

IASPP_MOUSE
θ value	0.0961366 (rank : 367)	NC score	0.578517 (rank : 162)
Query Neighborhood Hits	467	Target Neighborhood Hits	1024	Shared Neighborhood Hits	384
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP1_MOUSE
θ value	0.0961366 (rank : 368)	NC score	0.118277 (rank : 510)
Query Neighborhood Hits	467	Target Neighborhood Hits	259	Shared Neighborhood Hits	63
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NFKB1_MOUSE
θ value	0.0961366 (rank : 369)	NC score	0.541902 (rank : 179)
Query Neighborhood Hits	467	Target Neighborhood Hits	300	Shared Neighborhood Hits	244
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

RFXK_HUMAN
θ value	0.0961366 (rank : 370)	NC score	0.650527 (rank : 83)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	242
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

SHAN2_MOUSE
θ value	0.0961366 (rank : 371)	NC score	0.194033 (rank : 410)
Query Neighborhood Hits	467	Target Neighborhood Hits	446	Shared Neighborhood Hits	123
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

AN30A_HUMAN
θ value	0.125558 (rank : 372)	NC score	0.459861 (rank : 240)
Query Neighborhood Hits	467	Target Neighborhood Hits	1119	Shared Neighborhood Hits	254
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANR18_HUMAN
θ value	0.125558 (rank : 373)	NC score	0.479269 (rank : 211)
Query Neighborhood Hits	467	Target Neighborhood Hits	1106	Shared Neighborhood Hits	255
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR43_MOUSE
θ value	0.125558 (rank : 374)	NC score	0.475279 (rank : 221)
Query Neighborhood Hits	467	Target Neighborhood Hits	214	Shared Neighborhood Hits	189
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ARHG9_HUMAN
θ value	0.125558 (rank : 375)	NC score	0.274469 (rank : 363)
Query Neighborhood Hits	467	Target Neighborhood Hits	235	Shared Neighborhood Hits	155
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.125558 (rank : 376)	NC score	0.274189 (rank : 364)
Query Neighborhood Hits	467	Target Neighborhood Hits	234	Shared Neighborhood Hits	155
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

JIP1_HUMAN
θ value	0.125558 (rank : 377)	NC score	0.119366 (rank : 506)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MPP5_HUMAN
θ value	0.125558 (rank : 378)	NC score	0.119328 (rank : 507)
Query Neighborhood Hits	467	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.125558 (rank : 379)	NC score	0.118652 (rank : 509)
Query Neighborhood Hits	467	Target Neighborhood Hits	226	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

POTE8_HUMAN
θ value	0.125558 (rank : 380)	NC score	0.594197 (rank : 145)
Query Neighborhood Hits	467	Target Neighborhood Hits	337	Shared Neighborhood Hits	249
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

SRGP1_HUMAN
θ value	0.125558 (rank : 381)	NC score	0.215085 (rank : 396)
Query Neighborhood Hits	467	Target Neighborhood Hits	390	Shared Neighborhood Hits	149
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STS2_HUMAN
θ value	0.125558 (rank : 382)	NC score	0.191771 (rank : 413)
Query Neighborhood Hits	467	Target Neighborhood Hits	108	Shared Neighborhood Hits	82
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ABI3_MOUSE
θ value	0.163984 (rank : 383)	NC score	0.371406 (rank : 300)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANM2_HUMAN
θ value	0.163984 (rank : 384)	NC score	0.238511 (rank : 384)
Query Neighborhood Hits	467	Target Neighborhood Hits	175	Shared Neighborhood Hits	147
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANR40_HUMAN
θ value	0.163984 (rank : 385)	NC score	0.477699 (rank : 217)
Query Neighborhood Hits	467	Target Neighborhood Hits	224	Shared Neighborhood Hits	191
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

CSKP_HUMAN
θ value	0.163984 (rank : 386)	NC score	0.076094 (rank : 667)
Query Neighborhood Hits	467	Target Neighborhood Hits	1022	Shared Neighborhood Hits	141
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DOCK1_HUMAN
θ value	0.163984 (rank : 387)	NC score	0.125652 (rank : 498)
Query Neighborhood Hits	467	Target Neighborhood Hits	191	Shared Neighborhood Hits	115
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

IASPP_HUMAN
θ value	0.163984 (rank : 388)	NC score	0.636867 (rank : 105)
Query Neighborhood Hits	467	Target Neighborhood Hits	688	Shared Neighborhood Hits	376
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBE_HUMAN
θ value	0.163984 (rank : 389)	NC score	0.593681 (rank : 147)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	239
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

ZDH13_HUMAN
θ value	0.163984 (rank : 390)	NC score	0.567139 (rank : 165)
Query Neighborhood Hits	467	Target Neighborhood Hits	322	Shared Neighborhood Hits	247
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

DGKI_HUMAN
θ value	0.21417 (rank : 391)	NC score	0.280892 (rank : 361)
Query Neighborhood Hits	467	Target Neighborhood Hits	609	Shared Neighborhood Hits	198
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

ANR22_HUMAN
θ value	0.279714 (rank : 392)	NC score	0.634950 (rank : 108)
Query Neighborhood Hits	467	Target Neighborhood Hits	243	Shared Neighborhood Hits	227
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ARHG4_MOUSE
θ value	0.279714 (rank : 393)	NC score	0.234512 (rank : 386)
Query Neighborhood Hits	467	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CD2A1_MOUSE
θ value	0.279714 (rank : 394)	NC score	0.530583 (rank : 187)
Query Neighborhood Hits	467	Target Neighborhood Hits	206	Shared Neighborhood Hits	192
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

CENB1_HUMAN
θ value	0.365318 (rank : 395)	NC score	0.418304 (rank : 265)
Query Neighborhood Hits	467	Target Neighborhood Hits	383	Shared Neighborhood Hits	230
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDFL1_HUMAN
θ value	0.365318 (rank : 396)	NC score	0.307337 (rank : 345)
Query Neighborhood Hits	467	Target Neighborhood Hits	353	Shared Neighborhood Hits	212
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

MPP6_HUMAN
θ value	0.365318 (rank : 397)	NC score	0.142921 (rank : 477)
Query Neighborhood Hits	467	Target Neighborhood Hits	180	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	0.365318 (rank : 398)	NC score	0.139385 (rank : 483)
Query Neighborhood Hits	467	Target Neighborhood Hits	187	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NPHP1_MOUSE
θ value	0.365318 (rank : 399)	NC score	0.345681 (rank : 317)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	180
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ABTB2_MOUSE
θ value	0.47712 (rank : 400)	NC score	0.448794 (rank : 251)
Query Neighborhood Hits	467	Target Neighborhood Hits	414	Shared Neighborhood Hits	225
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ANR40_MOUSE
θ value	0.47712 (rank : 401)	NC score	0.473851 (rank : 223)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	194
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR42_HUMAN
θ value	0.47712 (rank : 402)	NC score	0.656032 (rank : 73)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	253
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

JIP2_HUMAN
θ value	0.47712 (rank : 403)	NC score	0.117899 (rank : 511)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	66
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.47712 (rank : 404)	NC score	0.117381 (rank : 512)
Query Neighborhood Hits	467	Target Neighborhood Hits	144	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MPP4_MOUSE
θ value	0.47712 (rank : 405)	NC score	0.117284 (rank : 514)
Query Neighborhood Hits	467	Target Neighborhood Hits	188	Shared Neighborhood Hits	73
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

RUSC1_MOUSE
θ value	0.47712 (rank : 406)	NC score	0.213367 (rank : 397)
Query Neighborhood Hits	467	Target Neighborhood Hits	206	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ABTB2_HUMAN
θ value	0.62314 (rank : 407)	NC score	0.458131 (rank : 244)
Query Neighborhood Hits	467	Target Neighborhood Hits	391	Shared Neighborhood Hits	225
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ASB12_MOUSE
θ value	0.62314 (rank : 408)	NC score	0.611708 (rank : 134)
Query Neighborhood Hits	467	Target Neighborhood Hits	261	Shared Neighborhood Hits	234
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

EFS_HUMAN
θ value	0.62314 (rank : 409)	NC score	0.266482 (rank : 365)
Query Neighborhood Hits	467	Target Neighborhood Hits	348	Shared Neighborhood Hits	153
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.62314 (rank : 410)	NC score	0.276854 (rank : 362)
Query Neighborhood Hits	467	Target Neighborhood Hits	389	Shared Neighborhood Hits	156
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MPP2_HUMAN
θ value	0.62314 (rank : 411)	NC score	0.120408 (rank : 504)
Query Neighborhood Hits	467	Target Neighborhood Hits	173	Shared Neighborhood Hits	82
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	0.62314 (rank : 412)	NC score	0.120052 (rank : 505)
Query Neighborhood Hits	467	Target Neighborhood Hits	189	Shared Neighborhood Hits	81
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

NPHP1_HUMAN
θ value	0.62314 (rank : 413)	NC score	0.307450 (rank : 344)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	159
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RUSC1_HUMAN
θ value	0.62314 (rank : 414)	NC score	0.232263 (rank : 388)
Query Neighborhood Hits	467	Target Neighborhood Hits	226	Shared Neighborhood Hits	134
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ANR19_HUMAN
θ value	0.813845 (rank : 415)	NC score	0.592488 (rank : 149)
Query Neighborhood Hits	467	Target Neighborhood Hits	276	Shared Neighborhood Hits	244
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

SNX18_MOUSE
θ value	0.813845 (rank : 416)	NC score	0.244989 (rank : 378)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SRMS_MOUSE
θ value	0.813845 (rank : 417)	NC score	0.123026 (rank : 501)
Query Neighborhood Hits	467	Target Neighborhood Hits	964	Shared Neighborhood Hits	117
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

CDN2B_MOUSE
θ value	1.06291 (rank : 418)	NC score	0.489393 (rank : 205)
Query Neighborhood Hits	467	Target Neighborhood Hits	201	Shared Neighborhood Hits	185
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

LRRK1_HUMAN
θ value	1.06291 (rank : 419)	NC score	0.099913 (rank : 544)
Query Neighborhood Hits	467	Target Neighborhood Hits	1237	Shared Neighborhood Hits	129
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

SNX18_HUMAN
θ value	1.06291 (rank : 420)	NC score	0.239910 (rank : 382)
Query Neighborhood Hits	467	Target Neighborhood Hits	207	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

TRPV5_HUMAN
θ value	1.06291 (rank : 421)	NC score	0.323537 (rank : 335)
Query Neighborhood Hits	467	Target Neighborhood Hits	261	Shared Neighborhood Hits	199
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV5_MOUSE
θ value	1.06291 (rank : 422)	NC score	0.352668 (rank : 313)
Query Neighborhood Hits	467	Target Neighborhood Hits	278	Shared Neighborhood Hits	215
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

ZDH13_MOUSE
θ value	1.06291 (rank : 423)	NC score	0.565023 (rank : 167)
Query Neighborhood Hits	467	Target Neighborhood Hits	329	Shared Neighborhood Hits	248
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

CMTA2_HUMAN
θ value	1.38821 (rank : 424)	NC score	0.140357 (rank : 481)
Query Neighborhood Hits	467	Target Neighborhood Hits	199	Shared Neighborhood Hits	87
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
θ value	1.38821 (rank : 425)	NC score	0.128591 (rank : 491)
Query Neighborhood Hits	467	Target Neighborhood Hits	216	Shared Neighborhood Hits	73
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CT012_HUMAN
θ value	1.38821 (rank : 426)	NC score	0.323082 (rank : 337)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

DLG3_HUMAN
θ value	1.38821 (rank : 427)	NC score	0.078840 (rank : 624)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	83
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	1.38821 (rank : 428)	NC score	0.078337 (rank : 628)
Query Neighborhood Hits	467	Target Neighborhood Hits	274	Shared Neighborhood Hits	83
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

LRRK1_MOUSE
θ value	1.38821 (rank : 429)	NC score	0.118693 (rank : 508)
Query Neighborhood Hits	467	Target Neighborhood Hits	1267	Shared Neighborhood Hits	154
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

NOTC2_HUMAN
θ value	1.38821 (rank : 430)	NC score	0.295745 (rank : 355)
Query Neighborhood Hits	467	Target Neighborhood Hits	1113	Shared Neighborhood Hits	251
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DLG5_HUMAN
θ value	1.81305 (rank : 431)	NC score	0.054826 (rank : 848)
Query Neighborhood Hits	467	Target Neighborhood Hits	1088	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EPS8_HUMAN
θ value	1.81305 (rank : 432)	NC score	0.158737 (rank : 445)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	104
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

GLSK_HUMAN
θ value	1.81305 (rank : 433)	NC score	0.372348 (rank : 299)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	179
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

MPP3_MOUSE
θ value	1.81305 (rank : 434)	NC score	0.085541 (rank : 577)
Query Neighborhood Hits	467	Target Neighborhood Hits	165	Shared Neighborhood Hits	46
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

NOTC2_MOUSE
θ value	1.81305 (rank : 435)	NC score	0.293375 (rank : 357)
Query Neighborhood Hits	467	Target Neighborhood Hits	1069	Shared Neighborhood Hits	251
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SLY_MOUSE
θ value	1.81305 (rank : 436)	NC score	0.134682 (rank : 486)
Query Neighborhood Hits	467	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

DLG1_HUMAN
θ value	2.36792 (rank : 437)	NC score	0.078042 (rank : 632)
Query Neighborhood Hits	467	Target Neighborhood Hits	290	Shared Neighborhood Hits	79
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

IKBA_MOUSE
θ value	2.36792 (rank : 438)	NC score	0.599368 (rank : 142)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	240
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

DLG1_MOUSE
θ value	3.0926 (rank : 439)	NC score	0.076018 (rank : 669)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

SNX9_HUMAN
θ value	3.0926 (rank : 440)	NC score	0.155162 (rank : 453)
Query Neighborhood Hits	467	Target Neighborhood Hits	148	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

AN13B_HUMAN
θ value	4.03905 (rank : 441)	NC score	0.388943 (rank : 289)
Query Neighborhood Hits	467	Target Neighborhood Hits	265	Shared Neighborhood Hits	227
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	4.03905 (rank : 442)	NC score	0.389192 (rank : 287)
Query Neighborhood Hits	467	Target Neighborhood Hits	276	Shared Neighborhood Hits	227
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

CLPB_HUMAN
θ value	4.03905 (rank : 443)	NC score	0.456267 (rank : 246)
Query Neighborhood Hits	467	Target Neighborhood Hits	265	Shared Neighborhood Hits	215
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

GLSL_HUMAN
θ value	4.03905 (rank : 444)	NC score	0.411870 (rank : 268)
Query Neighborhood Hits	467	Target Neighborhood Hits	211	Shared Neighborhood Hits	193
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

RUSC2_MOUSE
θ value	4.03905 (rank : 445)	NC score	0.085690 (rank : 576)
Query Neighborhood Hits	467	Target Neighborhood Hits	305	Shared Neighborhood Hits	68
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

S3TC1_HUMAN
θ value	4.03905 (rank : 446)	NC score	0.034653 (rank : 870)
Query Neighborhood Hits	467	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

ACK1_HUMAN
θ value	5.27518 (rank : 447)	NC score	0.094573 (rank : 556)
Query Neighborhood Hits	467	Target Neighborhood Hits	1140	Shared Neighborhood Hits	97
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	5.27518 (rank : 448)	NC score	0.095464 (rank : 554)
Query Neighborhood Hits	467	Target Neighborhood Hits	1080	Shared Neighborhood Hits	101
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ANKF1_HUMAN
θ value	5.27518 (rank : 449)	NC score	0.110296 (rank : 521)
Query Neighborhood Hits	467	Target Neighborhood Hits	126	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

BLK_HUMAN
θ value	5.27518 (rank : 450)	NC score	0.151406 (rank : 459)
Query Neighborhood Hits	467	Target Neighborhood Hits	994	Shared Neighborhood Hits	154
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CD2A1_HUMAN
θ value	5.27518 (rank : 451)	NC score	0.461363 (rank : 237)
Query Neighborhood Hits	467	Target Neighborhood Hits	196	Shared Neighborhood Hits	180
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

EPS8_MOUSE
θ value	5.27518 (rank : 452)	NC score	0.158130 (rank : 447)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	119
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

GLSL_MOUSE
θ value	5.27518 (rank : 453)	NC score	0.403072 (rank : 274)
Query Neighborhood Hits	467	Target Neighborhood Hits	212	Shared Neighborhood Hits	194
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

MPP3_HUMAN
θ value	5.27518 (rank : 454)	NC score	0.084820 (rank : 580)
Query Neighborhood Hits	467	Target Neighborhood Hits	171	Shared Neighborhood Hits	47
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

NOXO1_HUMAN
θ value	5.27518 (rank : 455)	NC score	0.188657 (rank : 420)
Query Neighborhood Hits	467	Target Neighborhood Hits	100	Shared Neighborhood Hits	89
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

CMTA1_HUMAN
θ value	6.88961 (rank : 456)	NC score	0.156140 (rank : 451)
Query Neighborhood Hits	467	Target Neighborhood Hits	217	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

DLG4_HUMAN
θ value	6.88961 (rank : 457)	NC score	0.077674 (rank : 639)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	86
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	6.88961 (rank : 458)	NC score	0.074262 (rank : 698)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	82
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PEX13_HUMAN
θ value	6.88961 (rank : 459)	NC score	0.243188 (rank : 381)
Query Neighborhood Hits	467	Target Neighborhood Hits	128	Shared Neighborhood Hits	113
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SASH1_HUMAN
θ value	6.88961 (rank : 460)	NC score	0.089127 (rank : 566)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	68
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SLY_HUMAN
θ value	6.88961 (rank : 461)	NC score	0.117297 (rank : 513)
Query Neighborhood Hits	467	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SNX9_MOUSE
θ value	6.88961 (rank : 462)	NC score	0.140518 (rank : 480)
Query Neighborhood Hits	467	Target Neighborhood Hits	141	Shared Neighborhood Hits	88
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

TRPV3_MOUSE
θ value	6.88961 (rank : 463)	NC score	0.149371 (rank : 462)
Query Neighborhood Hits	467	Target Neighborhood Hits	188	Shared Neighborhood Hits	118
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

CCD94_MOUSE
θ value	8.99809 (rank : 464)	NC score	0.020695 (rank : 872)
Query Neighborhood Hits	467	Target Neighborhood Hits	127	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D6J3	Gene names	Ccdc94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

PEX13_MOUSE
θ value	8.99809 (rank : 465)	NC score	0.239386 (rank : 383)
Query Neighborhood Hits	467	Target Neighborhood Hits	126	Shared Neighborhood Hits	117
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RSNL2_HUMAN
θ value	8.99809 (rank : 466)	NC score	0.172626 (rank : 429)
Query Neighborhood Hits	467	Target Neighborhood Hits	136	Shared Neighborhood Hits	109
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

ZO2_MOUSE
θ value	8.99809 (rank : 467)	NC score	0.023223 (rank : 871)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

3BP1_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.050044 (rank : 868)
Query Neighborhood Hits	467	Target Neighborhood Hits	376	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AATK_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.073860 (rank : 704)
Query Neighborhood Hits	467	Target Neighborhood Hits	1243	Shared Neighborhood Hits	60
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.075570 (rank : 676)
Query Neighborhood Hits	467	Target Neighborhood Hits	942	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.134036 (rank : 488)
Query Neighborhood Hits	467	Target Neighborhood Hits	1220	Shared Neighborhood Hits	149
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.132786 (rank : 489)
Query Neighborhood Hits	467	Target Neighborhood Hits	1178	Shared Neighborhood Hits	144
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.131814 (rank : 490)
Query Neighborhood Hits	467	Target Neighborhood Hits	1045	Shared Neighborhood Hits	135
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.059043 (rank : 824)
Query Neighborhood Hits	467	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACV1B_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.057932 (rank : 834)
Query Neighborhood Hits	467	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.057638 (rank : 837)
Query Neighborhood Hits	467	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.057230 (rank : 841)
Query Neighborhood Hits	467	Target Neighborhood Hits	709	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.057805 (rank : 835)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.061921 (rank : 802)
Query Neighborhood Hits	467	Target Neighborhood Hits	716	Shared Neighborhood Hits	45
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.062005 (rank : 801)
Query Neighborhood Hits	467	Target Neighborhood Hits	739	Shared Neighborhood Hits	45
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.060135 (rank : 812)
Query Neighborhood Hits	467	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.059445 (rank : 821)
Query Neighborhood Hits	467	Target Neighborhood Hits	768	Shared Neighborhood Hits	49
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ALK_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.079919 (rank : 615)
Query Neighborhood Hits	467	Target Neighborhood Hits	795	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.080373 (rank : 609)
Query Neighborhood Hits	467	Target Neighborhood Hits	811	Shared Neighborhood Hits	54
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.066926 (rank : 769)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	45
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMPH_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.106707 (rank : 525)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	80
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.098575 (rank : 548)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

AN13A_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.330355 (rank : 329)
Query Neighborhood Hits	467	Target Neighborhood Hits	243	Shared Neighborhood Hits	201
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

AN13A_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.312140 (rank : 342)
Query Neighborhood Hits	467	Target Neighborhood Hits	226	Shared Neighborhood Hits	197
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

AN13C_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.373537 (rank : 298)
Query Neighborhood Hits	467	Target Neighborhood Hits	241	Shared Neighborhood Hits	213
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13C_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.366500 (rank : 302)
Query Neighborhood Hits	467	Target Neighborhood Hits	242	Shared Neighborhood Hits	210
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

ANKR9_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.161515 (rank : 444)
Query Neighborhood Hits	467	Target Neighborhood Hits	99	Shared Neighborhood Hits	84
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANKR9_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.197207 (rank : 407)
Query Neighborhood Hits	467	Target Neighborhood Hits	120	Shared Neighborhood Hits	103
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANKY1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.399695 (rank : 280)
Query Neighborhood Hits	467	Target Neighborhood Hits	248	Shared Neighborhood Hits	192
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ANKZ1_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.226331 (rank : 392)
Query Neighborhood Hits	467	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

ANKZ1_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.243733 (rank : 380)
Query Neighborhood Hits	467	Target Neighborhood Hits	208	Shared Neighborhood Hits	140
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ANPRA_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.070901 (rank : 742)
Query Neighborhood Hits	467	Target Neighborhood Hits	612	Shared Neighborhood Hits	46
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.071374 (rank : 734)
Query Neighborhood Hits	467	Target Neighborhood Hits	600	Shared Neighborhood Hits	46
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.073182 (rank : 709)
Query Neighborhood Hits	467	Target Neighborhood Hits	646	Shared Neighborhood Hits	47
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.075411 (rank : 681)
Query Neighborhood Hits	467	Target Neighborhood Hits	607	Shared Neighborhood Hits	47
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANR41_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.556653 (rank : 175)
Query Neighborhood Hits	467	Target Neighborhood Hits	332	Shared Neighborhood Hits	228
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR43_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.469290 (rank : 229)
Query Neighborhood Hits	467	Target Neighborhood Hits	209	Shared Neighborhood Hits	186
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR46_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.615410 (rank : 126)
Query Neighborhood Hits	467	Target Neighborhood Hits	281	Shared Neighborhood Hits	247
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR46_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.607732 (rank : 137)
Query Neighborhood Hits	467	Target Neighborhood Hits	274	Shared Neighborhood Hits	242
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

APS_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.098725 (rank : 547)
Query Neighborhood Hits	467	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.074161 (rank : 699)
Query Neighborhood Hits	467	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARAF_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.073108 (rank : 710)
Query Neighborhood Hits	467	Target Neighborhood Hits	924	Shared Neighborhood Hits	64
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.072977 (rank : 712)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG1_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.066102 (rank : 780)
Query Neighborhood Hits	467	Target Neighborhood Hits	176	Shared Neighborhood Hits	18
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.058727 (rank : 827)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.057555 (rank : 838)
Query Neighborhood Hits	467	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.054814 (rank : 849)
Query Neighborhood Hits	467	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.101484 (rank : 541)
Query Neighborhood Hits	467	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.101634 (rank : 540)
Query Neighborhood Hits	467	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.088518 (rank : 568)
Query Neighborhood Hits	467	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.099550 (rank : 545)
Query Neighborhood Hits	467	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.083786 (rank : 583)
Query Neighborhood Hits	467	Target Neighborhood Hits	187	Shared Neighborhood Hits	24
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.086607 (rank : 570)
Query Neighborhood Hits	467	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.068116 (rank : 759)
Query Neighborhood Hits	467	Target Neighborhood Hits	375	Shared Neighborhood Hits	38
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.069319 (rank : 750)
Query Neighborhood Hits	467	Target Neighborhood Hits	351	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.069045 (rank : 752)
Query Neighborhood Hits	467	Target Neighborhood Hits	344	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.058055 (rank : 832)
Query Neighborhood Hits	467	Target Neighborhood Hits	214	Shared Neighborhood Hits	24
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.094389 (rank : 557)
Query Neighborhood Hits	467	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.111066 (rank : 519)
Query Neighborhood Hits	467	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASB14_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.386206 (rank : 291)
Query Neighborhood Hits	467	Target Neighborhood Hits	187	Shared Neighborhood Hits	169
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB6_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.534939 (rank : 184)
Query Neighborhood Hits	467	Target Neighborhood Hits	264	Shared Neighborhood Hits	221
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

AVR2A_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.050968 (rank : 862)
Query Neighborhood Hits	467	Target Neighborhood Hits	767	Shared Neighborhood Hits	49
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.050970 (rank : 861)
Query Neighborhood Hits	467	Target Neighborhood Hits	767	Shared Neighborhood Hits	49
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.051463 (rank : 858)
Query Neighborhood Hits	467	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.051539 (rank : 857)
Query Neighborhood Hits	467	Target Neighborhood Hits	749	Shared Neighborhood Hits	49
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

BAIP2_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.072988 (rank : 711)
Query Neighborhood Hits	467	Target Neighborhood Hits	192	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.073991 (rank : 702)
Query Neighborhood Hits	467	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAT4_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.188633 (rank : 421)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	104
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BAT4_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.206750 (rank : 401)
Query Neighborhood Hits	467	Target Neighborhood Hits	171	Shared Neighborhood Hits	114
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BCAR3_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.060651 (rank : 810)
Query Neighborhood Hits	467	Target Neighborhood Hits	129	Shared Neighborhood Hits	36
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.059457 (rank : 820)
Query Neighborhood Hits	467	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.068490 (rank : 754)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	30
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.089235 (rank : 564)
Query Neighborhood Hits	467	Target Neighborhood Hits	156	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.066259 (rank : 778)
Query Neighborhood Hits	467	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.092384 (rank : 559)
Query Neighborhood Hits	467	Target Neighborhood Hits	335	Shared Neighborhood Hits	72
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.089270 (rank : 563)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	75
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.147961 (rank : 466)
Query Neighborhood Hits	467	Target Neighborhood Hits	992	Shared Neighborhood Hits	145
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.055581 (rank : 847)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.059620 (rank : 818)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMPR2_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.050158 (rank : 866)
Query Neighborhood Hits	467	Target Neighborhood Hits	736	Shared Neighborhood Hits	49
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMR1A_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.064354 (rank : 788)
Query Neighborhood Hits	467	Target Neighborhood Hits	759	Shared Neighborhood Hits	50
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.064681 (rank : 785)
Query Neighborhood Hits	467	Target Neighborhood Hits	758	Shared Neighborhood Hits	50
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.066758 (rank : 771)
Query Neighborhood Hits	467	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.067315 (rank : 765)
Query Neighborhood Hits	467	Target Neighborhood Hits	758	Shared Neighborhood Hits	49
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.102543 (rank : 536)
Query Neighborhood Hits	467	Target Neighborhood Hits	942	Shared Neighborhood Hits	73
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.102955 (rank : 533)
Query Neighborhood Hits	467	Target Neighborhood Hits	912	Shared Neighborhood Hits	71
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.074917 (rank : 692)
Query Neighborhood Hits	467	Target Neighborhood Hits	883	Shared Neighborhood Hits	62
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CDN2D_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.622715 (rank : 118)
Query Neighborhood Hits	467	Target Neighborhood Hits	268	Shared Neighborhood Hits	238
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CDN2D_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.616405 (rank : 125)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	237
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CENG1_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.243777 (rank : 379)
Query Neighborhood Hits	467	Target Neighborhood Hits	544	Shared Neighborhood Hits	216
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.246216 (rank : 377)
Query Neighborhood Hits	467	Target Neighborhood Hits	531	Shared Neighborhood Hits	216
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.247497 (rank : 374)
Query Neighborhood Hits	467	Target Neighborhood Hits	471	Shared Neighborhood Hits	225
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.246380 (rank : 376)
Query Neighborhood Hits	467	Target Neighborhood Hits	463	Shared Neighborhood Hits	224
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG3_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.211046 (rank : 400)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	203
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.212022 (rank : 399)
Query Neighborhood Hits	467	Target Neighborhood Hits	467	Shared Neighborhood Hits	206
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CHIN_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.071468 (rank : 733)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.073214 (rank : 708)
Query Neighborhood Hits	467	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.070350 (rank : 745)
Query Neighborhood Hits	467	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.127305 (rank : 494)
Query Neighborhood Hits	467	Target Neighborhood Hits	374	Shared Neighborhood Hits	79
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CLR59_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.216567 (rank : 395)
Query Neighborhood Hits	467	Target Neighborhood Hits	163	Shared Neighborhood Hits	134
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

CSF1R_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.071984 (rank : 725)
Query Neighborhood Hits	467	Target Neighborhood Hits	943	Shared Neighborhood Hits	51
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.070562 (rank : 743)
Query Neighborhood Hits	467	Target Neighborhood Hits	983	Shared Neighborhood Hits	51
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CT012_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.330334 (rank : 330)
Query Neighborhood Hits	467	Target Neighborhood Hits	229	Shared Neighborhood Hits	162
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

CU081_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.086022 (rank : 574)
Query Neighborhood Hits	467	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

DAPP1_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.127736 (rank : 492)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.127549 (rank : 493)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDR1_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.080240 (rank : 612)
Query Neighborhood Hits	467	Target Neighborhood Hits	819	Shared Neighborhood Hits	51
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.081278 (rank : 599)
Query Neighborhood Hits	467	Target Neighborhood Hits	818	Shared Neighborhood Hits	51
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.076159 (rank : 665)
Query Neighborhood Hits	467	Target Neighborhood Hits	818	Shared Neighborhood Hits	53
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.075146 (rank : 687)
Query Neighborhood Hits	467	Target Neighborhood Hits	813	Shared Neighborhood Hits	51
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DLG2_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.078012 (rank : 633)
Query Neighborhood Hits	467	Target Neighborhood Hits	279	Shared Neighborhood Hits	85
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.077407 (rank : 644)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	85
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DUET_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.057933 (rank : 833)
Query Neighborhood Hits	467	Target Neighborhood Hits	1220	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.077980 (rank : 634)
Query Neighborhood Hits	467	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.080782 (rank : 605)
Query Neighborhood Hits	467	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EGFR_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.076122 (rank : 666)
Query Neighborhood Hits	467	Target Neighborhood Hits	939	Shared Neighborhood Hits	54
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.075947 (rank : 670)
Query Neighborhood Hits	467	Target Neighborhood Hits	927	Shared Neighborhood Hits	53
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.084274 (rank : 581)
Query Neighborhood Hits	467	Target Neighborhood Hits	997	Shared Neighborhood Hits	66
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.083654 (rank : 584)
Query Neighborhood Hits	467	Target Neighborhood Hits	958	Shared Neighborhood Hits	63
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.081327 (rank : 598)
Query Neighborhood Hits	467	Target Neighborhood Hits	1021	Shared Neighborhood Hits	63
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.082105 (rank : 591)
Query Neighborhood Hits	467	Target Neighborhood Hits	1020	Shared Neighborhood Hits	63
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.074798 (rank : 694)
Query Neighborhood Hits	467	Target Neighborhood Hits	1005	Shared Neighborhood Hits	59
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.074543 (rank : 696)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	59
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.077714 (rank : 638)
Query Neighborhood Hits	467	Target Neighborhood Hits	975	Shared Neighborhood Hits	63
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.077834 (rank : 637)
Query Neighborhood Hits	467	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.080690 (rank : 607)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	67
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.083212 (rank : 586)
Query Neighborhood Hits	467	Target Neighborhood Hits	950	Shared Neighborhood Hits	66
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.081270 (rank : 600)
Query Neighborhood Hits	467	Target Neighborhood Hits	959	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.080800 (rank : 604)
Query Neighborhood Hits	467	Target Neighborhood Hits	946	Shared Neighborhood Hits	61
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.078897 (rank : 623)
Query Neighborhood Hits	467	Target Neighborhood Hits	1053	Shared Neighborhood Hits	67
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.078784 (rank : 626)
Query Neighborhood Hits	467	Target Neighborhood Hits	1025	Shared Neighborhood Hits	64
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.079475 (rank : 618)
Query Neighborhood Hits	467	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.080340 (rank : 611)
Query Neighborhood Hits	467	Target Neighborhood Hits	969	Shared Neighborhood Hits	63
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.080131 (rank : 613)
Query Neighborhood Hits	467	Target Neighborhood Hits	960	Shared Neighborhood Hits	65
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.078791 (rank : 625)
Query Neighborhood Hits	467	Target Neighborhood Hits	988	Shared Neighborhood Hits	66
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.079920 (rank : 614)
Query Neighborhood Hits	467	Target Neighborhood Hits	983	Shared Neighborhood Hits	62
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.079427 (rank : 620)
Query Neighborhood Hits	467	Target Neighborhood Hits	982	Shared Neighborhood Hits	62
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.079635 (rank : 617)
Query Neighborhood Hits	467	Target Neighborhood Hits	996	Shared Neighborhood Hits	66
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.079160 (rank : 622)
Query Neighborhood Hits	467	Target Neighborhood Hits	996	Shared Neighborhood Hits	64
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.081560 (rank : 594)
Query Neighborhood Hits	467	Target Neighborhood Hits	1056	Shared Neighborhood Hits	71
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.080850 (rank : 603)
Query Neighborhood Hits	467	Target Neighborhood Hits	1013	Shared Neighborhood Hits	68
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.082476 (rank : 589)
Query Neighborhood Hits	467	Target Neighborhood Hits	912	Shared Neighborhood Hits	64
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.081930 (rank : 592)
Query Neighborhood Hits	467	Target Neighborhood Hits	906	Shared Neighborhood Hits	62
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.077862 (rank : 636)
Query Neighborhood Hits	467	Target Neighborhood Hits	1073	Shared Neighborhood Hits	57
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.077935 (rank : 635)
Query Neighborhood Hits	467	Target Neighborhood Hits	918	Shared Neighborhood Hits	54
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.075361 (rank : 683)
Query Neighborhood Hits	467	Target Neighborhood Hits	918	Shared Neighborhood Hits	58
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.075173 (rank : 685)
Query Neighborhood Hits	467	Target Neighborhood Hits	898	Shared Neighborhood Hits	57
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.080857 (rank : 602)
Query Neighborhood Hits	467	Target Neighborhood Hits	910	Shared Neighborhood Hits	59
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.158725 (rank : 446)
Query Neighborhood Hits	467	Target Neighborhood Hits	162	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.153587 (rank : 456)
Query Neighborhood Hits	467	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.169394 (rank : 433)
Query Neighborhood Hits	467	Target Neighborhood Hits	193	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.166883 (rank : 437)
Query Neighborhood Hits	467	Target Neighborhood Hits	169	Shared Neighborhood Hits	120
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FAK1_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.077261 (rank : 645)
Query Neighborhood Hits	467	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.077138 (rank : 647)
Query Neighborhood Hits	467	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.080862 (rank : 601)
Query Neighborhood Hits	467	Target Neighborhood Hits	847	Shared Neighborhood Hits	53
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.080384 (rank : 608)
Query Neighborhood Hits	467	Target Neighborhood Hits	851	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FARP2_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.052840 (rank : 853)
Query Neighborhood Hits	467	Target Neighborhood Hits	209	Shared Neighborhood Hits	24
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.101852 (rank : 539)
Query Neighborhood Hits	467	Target Neighborhood Hits	1278	Shared Neighborhood Hits	96
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.085161 (rank : 579)
Query Neighborhood Hits	467	Target Neighborhood Hits	978	Shared Neighborhood Hits	70
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.083266 (rank : 585)
Query Neighborhood Hits	467	Target Neighborhood Hits	980	Shared Neighborhood Hits	67
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.056197 (rank : 844)
Query Neighborhood Hits	467	Target Neighborhood Hits	367	Shared Neighborhood Hits	37
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.053486 (rank : 852)
Query Neighborhood Hits	467	Target Neighborhood Hits	387	Shared Neighborhood Hits	34
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.064781 (rank : 784)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.060234 (rank : 811)
Query Neighborhood Hits	467	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.059630 (rank : 817)
Query Neighborhood Hits	467	Target Neighborhood Hits	249	Shared Neighborhood Hits	23
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.065687 (rank : 782)
Query Neighborhood Hits	467	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.067668 (rank : 763)
Query Neighborhood Hits	467	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.070968 (rank : 740)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.050236 (rank : 864)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	26
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGFR1_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.066461 (rank : 774)
Query Neighborhood Hits	467	Target Neighborhood Hits	1069	Shared Neighborhood Hits	52
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.066475 (rank : 773)
Query Neighborhood Hits	467	Target Neighborhood Hits	1068	Shared Neighborhood Hits	52
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.066481 (rank : 772)
Query Neighborhood Hits	467	Target Neighborhood Hits	1062	Shared Neighborhood Hits	52
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.066912 (rank : 770)
Query Neighborhood Hits	467	Target Neighborhood Hits	1062	Shared Neighborhood Hits	52
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.068308 (rank : 756)
Query Neighborhood Hits	467	Target Neighborhood Hits	1042	Shared Neighborhood Hits	53
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.067772 (rank : 762)
Query Neighborhood Hits	467	Target Neighborhood Hits	1059	Shared Neighborhood Hits	52
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.070957 (rank : 741)
Query Neighborhood Hits	467	Target Neighborhood Hits	1037	Shared Neighborhood Hits	52
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 642)	NC score	0.072205 (rank : 720)
Query Neighborhood Hits	467	Target Neighborhood Hits	1026	Shared Neighborhood Hits	52
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.073628 (rank : 707)
Query Neighborhood Hits	467	Target Neighborhood Hits	843	Shared Neighborhood Hits	52
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 644)	NC score	0.073958 (rank : 703)
Query Neighborhood Hits	467	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GIT1_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.348177 (rank : 315)
Query Neighborhood Hits	467	Target Neighborhood Hits	336	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	θ > 10 (rank : 646)	NC score	0.349028 (rank : 314)
Query Neighborhood Hits	467	Target Neighborhood Hits	341	Shared Neighborhood Hits	226
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT2_HUMAN
θ value	θ > 10 (rank : 647)	NC score	0.335023 (rank : 328)
Query Neighborhood Hits	467	Target Neighborhood Hits	381	Shared Neighborhood Hits	221
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.365311 (rank : 303)
Query Neighborhood Hits	467	Target Neighborhood Hits	323	Shared Neighborhood Hits	228
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GNRP_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.059825 (rank : 814)
Query Neighborhood Hits	467	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.063589 (rank : 792)
Query Neighborhood Hits	467	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.074333 (rank : 697)
Query Neighborhood Hits	467	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.076191 (rank : 662)
Query Neighborhood Hits	467	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.102285 (rank : 538)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 654)	NC score	0.104915 (rank : 530)
Query Neighborhood Hits	467	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.079865 (rank : 616)
Query Neighborhood Hits	467	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.091660 (rank : 561)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GUC2C_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.071994 (rank : 724)
Query Neighborhood Hits	467	Target Neighborhood Hits	624	Shared Neighborhood Hits	49
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.067543 (rank : 764)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.068318 (rank : 755)
Query Neighborhood Hits	467	Target Neighborhood Hits	692	Shared Neighborhood Hits	47
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.072743 (rank : 715)
Query Neighborhood Hits	467	Target Neighborhood Hits	740	Shared Neighborhood Hits	47
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.079163 (rank : 621)
Query Neighborhood Hits	467	Target Neighborhood Hits	644	Shared Neighborhood Hits	50
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HAPIP_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.071046 (rank : 739)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.096737 (rank : 551)
Query Neighborhood Hits	467	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.056349 (rank : 843)
Query Neighborhood Hits	467	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IGF1R_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.076515 (rank : 655)
Query Neighborhood Hits	467	Target Neighborhood Hits	977	Shared Neighborhood Hits	55
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 666)	NC score	0.076747 (rank : 649)
Query Neighborhood Hits	467	Target Neighborhood Hits	973	Shared Neighborhood Hits	54
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IKBL_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.246585 (rank : 375)
Query Neighborhood Hits	467	Target Neighborhood Hits	168	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

IKBL_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.247790 (rank : 373)
Query Neighborhood Hits	467	Target Neighborhood Hits	196	Shared Neighborhood Hits	132
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

INSRR_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.076178 (rank : 663)
Query Neighborhood Hits	467	Target Neighborhood Hits	950	Shared Neighborhood Hits	60
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.076563 (rank : 654)
Query Neighborhood Hits	467	Target Neighborhood Hits	961	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.076489 (rank : 657)
Query Neighborhood Hits	467	Target Neighborhood Hits	963	Shared Neighborhood Hits	58
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.074871 (rank : 693)
Query Neighborhood Hits	467	Target Neighborhood Hits	968	Shared Neighborhood Hits	55
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.071680 (rank : 731)
Query Neighborhood Hits	467	Target Neighborhood Hits	820	Shared Neighborhood Hits	52
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.072155 (rank : 721)
Query Neighborhood Hits	467	Target Neighborhood Hits	784	Shared Neighborhood Hits	50
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.075368 (rank : 682)
Query Neighborhood Hits	467	Target Neighborhood Hits	714	Shared Neighborhood Hits	48
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.076070 (rank : 668)
Query Neighborhood Hits	467	Target Neighborhood Hits	644	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.078213 (rank : 629)
Query Neighborhood Hits	467	Target Neighborhood Hits	628	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.063694 (rank : 791)
Query Neighborhood Hits	467	Target Neighborhood Hits	816	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.061629 (rank : 804)
Query Neighborhood Hits	467	Target Neighborhood Hits	820	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

JAK1_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.070497 (rank : 744)
Query Neighborhood Hits	467	Target Neighborhood Hits	858	Shared Neighborhood Hits	53
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.070210 (rank : 747)
Query Neighborhood Hits	467	Target Neighborhood Hits	854	Shared Neighborhood Hits	52
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.066198 (rank : 779)
Query Neighborhood Hits	467	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.065998 (rank : 781)
Query Neighborhood Hits	467	Target Neighborhood Hits	839	Shared Neighborhood Hits	52
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.067269 (rank : 766)
Query Neighborhood Hits	467	Target Neighborhood Hits	827	Shared Neighborhood Hits	52
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.064143 (rank : 789)
Query Neighborhood Hits	467	Target Neighborhood Hits	821	Shared Neighborhood Hits	52
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KGUA_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.059376 (rank : 822)
Query Neighborhood Hits	467	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.059328 (rank : 823)
Query Neighborhood Hits	467	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KIT_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.072823 (rank : 714)
Query Neighborhood Hits	467	Target Neighborhood Hits	953	Shared Neighborhood Hits	51
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.072931 (rank : 713)
Query Neighborhood Hits	467	Target Neighborhood Hits	949	Shared Neighborhood Hits	52
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.071295 (rank : 735)
Query Neighborhood Hits	467	Target Neighborhood Hits	867	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.069733 (rank : 749)
Query Neighborhood Hits	467	Target Neighborhood Hits	870	Shared Neighborhood Hits	55
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.073635 (rank : 706)
Query Neighborhood Hits	467	Target Neighborhood Hits	920	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.091800 (rank : 560)
Query Neighborhood Hits	467	Target Neighborhood Hits	901	Shared Neighborhood Hits	72
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.092711 (rank : 558)
Query Neighborhood Hits	467	Target Neighborhood Hits	944	Shared Neighborhood Hits	73
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.061722 (rank : 803)
Query Neighborhood Hits	467	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.078080 (rank : 631)
Query Neighborhood Hits	467	Target Neighborhood Hits	531	Shared Neighborhood Hits	52
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.078528 (rank : 627)
Query Neighborhood Hits	467	Target Neighborhood Hits	177	Shared Neighborhood Hits	42
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LIMK1_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.060675 (rank : 809)
Query Neighborhood Hits	467	Target Neighborhood Hits	1005	Shared Neighborhood Hits	67
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.061028 (rank : 806)
Query Neighborhood Hits	467	Target Neighborhood Hits	1008	Shared Neighborhood Hits	67
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.057541 (rank : 839)
Query Neighborhood Hits	467	Target Neighborhood Hits	986	Shared Neighborhood Hits	68
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.057320 (rank : 840)
Query Neighborhood Hits	467	Target Neighborhood Hits	998	Shared Neighborhood Hits	66
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LNK_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.086564 (rank : 571)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.083795 (rank : 582)
Query Neighborhood Hits	467	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRRK2_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.056529 (rank : 842)
Query Neighborhood Hits	467	Target Neighborhood Hits	1382	Shared Neighborhood Hits	64
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.058161 (rank : 831)
Query Neighborhood Hits	467	Target Neighborhood Hits	1359	Shared Neighborhood Hits	72
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.082517 (rank : 588)
Query Neighborhood Hits	467	Target Neighborhood Hits	774	Shared Neighborhood Hits	52
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.081402 (rank : 596)
Query Neighborhood Hits	467	Target Neighborhood Hits	770	Shared Neighborhood Hits	53
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K12_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.072043 (rank : 723)
Query Neighborhood Hits	467	Target Neighborhood Hits	940	Shared Neighborhood Hits	57
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.071953 (rank : 726)
Query Neighborhood Hits	467	Target Neighborhood Hits	957	Shared Neighborhood Hits	56
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.071241 (rank : 737)
Query Neighborhood Hits	467	Target Neighborhood Hits	911	Shared Neighborhood Hits	54
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K7_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.072721 (rank : 716)
Query Neighborhood Hits	467	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 712)	NC score	0.072714 (rank : 717)
Query Neighborhood Hits	467	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MATK_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.110232 (rank : 522)
Query Neighborhood Hits	467	Target Neighborhood Hits	954	Shared Neighborhood Hits	97
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.110587 (rank : 520)
Query Neighborhood Hits	467	Target Neighborhood Hits	952	Shared Neighborhood Hits	100
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.105792 (rank : 528)
Query Neighborhood Hits	467	Target Neighborhood Hits	255	Shared Neighborhood Hits	46
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.087563 (rank : 569)
Query Neighborhood Hits	467	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MERTK_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.077446 (rank : 642)
Query Neighborhood Hits	467	Target Neighborhood Hits	988	Shared Neighborhood Hits	51
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.077563 (rank : 641)
Query Neighborhood Hits	467	Target Neighborhood Hits	974	Shared Neighborhood Hits	50
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.076508 (rank : 656)
Query Neighborhood Hits	467	Target Neighborhood Hits	831	Shared Neighborhood Hits	52
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.076613 (rank : 653)
Query Neighborhood Hits	467	Target Neighborhood Hits	844	Shared Neighborhood Hits	54
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.086403 (rank : 572)
Query Neighborhood Hits	467	Target Neighborhood Hits	600	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.081392 (rank : 597)
Query Neighborhood Hits	467	Target Neighborhood Hits	707	Shared Neighborhood Hits	51
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.076690 (rank : 651)
Query Neighborhood Hits	467	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.076718 (rank : 650)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.075913 (rank : 671)
Query Neighborhood Hits	467	Target Neighborhood Hits	829	Shared Neighborhood Hits	52
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.075443 (rank : 680)
Query Neighborhood Hits	467	Target Neighborhood Hits	833	Shared Neighborhood Hits	52
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MUSK_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.068092 (rank : 760)
Query Neighborhood Hits	467	Target Neighborhood Hits	1074	Shared Neighborhood Hits	51
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.067827 (rank : 761)
Query Neighborhood Hits	467	Target Neighborhood Hits	1057	Shared Neighborhood Hits	51
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NEK11_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.050024 (rank : 869)
Query Neighborhood Hits	467	Target Neighborhood Hits	1043	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NGEF_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.124826 (rank : 500)
Query Neighborhood Hits	467	Target Neighborhood Hits	166	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 731)	NC score	0.126090 (rank : 496)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NTRK1_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.076396 (rank : 659)
Query Neighborhood Hits	467	Target Neighborhood Hits	1023	Shared Neighborhood Hits	51
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.072271 (rank : 718)
Query Neighborhood Hits	467	Target Neighborhood Hits	1081	Shared Neighborhood Hits	52
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.072267 (rank : 719)
Query Neighborhood Hits	467	Target Neighborhood Hits	1088	Shared Neighborhood Hits	52
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.073715 (rank : 705)
Query Neighborhood Hits	467	Target Neighborhood Hits	1115	Shared Neighborhood Hits	52
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

P55G_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.114919 (rank : 517)
Query Neighborhood Hits	467	Target Neighborhood Hits	451	Shared Neighborhood Hits	68
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.108524 (rank : 523)
Query Neighborhood Hits	467	Target Neighborhood Hits	401	Shared Neighborhood Hits	60
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.138209 (rank : 484)
Query Neighborhood Hits	467	Target Neighborhood Hits	479	Shared Neighborhood Hits	112
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 739)	NC score	0.145882 (rank : 471)
Query Neighborhood Hits	467	Target Neighborhood Hits	435	Shared Neighborhood Hits	115
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 740)	NC score	0.125819 (rank : 497)
Query Neighborhood Hits	467	Target Neighborhood Hits	543	Shared Neighborhood Hits	89
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 741)	NC score	0.125011 (rank : 499)
Query Neighborhood Hits	467	Target Neighborhood Hits	519	Shared Neighborhood Hits	90
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PGFRA_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.071777 (rank : 728)
Query Neighborhood Hits	467	Target Neighborhood Hits	980	Shared Neighborhood Hits	53
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 743)	NC score	0.072139 (rank : 722)
Query Neighborhood Hits	467	Target Neighborhood Hits	975	Shared Neighborhood Hits	53
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.071694 (rank : 730)
Query Neighborhood Hits	467	Target Neighborhood Hits	962	Shared Neighborhood Hits	51
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.071935 (rank : 727)
Query Neighborhood Hits	467	Target Neighborhood Hits	960	Shared Neighborhood Hits	53
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PKHG1_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.114860 (rank : 518)
Query Neighborhood Hits	467	Target Neighborhood Hits	174	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.060810 (rank : 808)
Query Neighborhood Hits	467	Target Neighborhood Hits	200	Shared Neighborhood Hits	22
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.058216 (rank : 830)
Query Neighborhood Hits	467	Target Neighborhood Hits	254	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.052541 (rank : 854)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.104850 (rank : 531)
Query Neighborhood Hits	467	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK7_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.066266 (rank : 777)
Query Neighborhood Hits	467	Target Neighborhood Hits	1103	Shared Neighborhood Hits	51
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN11_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.074035 (rank : 701)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.074048 (rank : 700)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.062350 (rank : 800)
Query Neighborhood Hits	467	Target Neighborhood Hits	234	Shared Neighborhood Hits	52
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.063124 (rank : 795)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RAF1_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.075654 (rank : 675)
Query Neighborhood Hits	467	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.074931 (rank : 691)
Query Neighborhood Hits	467	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RASA1_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.142390 (rank : 478)
Query Neighborhood Hits	467	Target Neighborhood Hits	258	Shared Neighborhood Hits	68
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RET_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.076466 (rank : 658)
Query Neighborhood Hits	467	Target Neighborhood Hits	873	Shared Neighborhood Hits	51
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.076166 (rank : 664)
Query Neighborhood Hits	467	Target Neighborhood Hits	884	Shared Neighborhood Hits	53
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RGNEF_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.062467 (rank : 799)
Query Neighborhood Hits	467	Target Neighborhood Hits	641	Shared Neighborhood Hits	43
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.058900 (rank : 826)
Query Neighborhood Hits	467	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.060876 (rank : 807)
Query Neighborhood Hits	467	Target Neighborhood Hits	190	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.064482 (rank : 787)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RIPK1_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.071621 (rank : 732)
Query Neighborhood Hits	467	Target Neighborhood Hits	891	Shared Neighborhood Hits	56
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.071171 (rank : 738)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	56
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.080747 (rank : 606)
Query Neighborhood Hits	467	Target Neighborhood Hits	774	Shared Neighborhood Hits	52
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.075003 (rank : 689)
Query Neighborhood Hits	467	Target Neighborhood Hits	776	Shared Neighborhood Hits	50
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.068170 (rank : 758)
Query Neighborhood Hits	467	Target Neighborhood Hits	828	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.071246 (rank : 736)
Query Neighborhood Hits	467	Target Neighborhood Hits	867	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK5_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.058648 (rank : 828)
Query Neighborhood Hits	467	Target Neighborhood Hits	864	Shared Neighborhood Hits	54
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.058969 (rank : 825)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.077427 (rank : 643)
Query Neighborhood Hits	467	Target Neighborhood Hits	842	Shared Neighborhood Hits	53
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.078138 (rank : 630)
Query Neighborhood Hits	467	Target Neighborhood Hits	836	Shared Neighborhood Hits	53
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.074988 (rank : 690)
Query Neighborhood Hits	467	Target Neighborhood Hits	1018	Shared Neighborhood Hits	52
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 776)	NC score	0.075165 (rank : 686)
Query Neighborhood Hits	467	Target Neighborhood Hits	1025	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 777)	NC score	0.075897 (rank : 672)
Query Neighborhood Hits	467	Target Neighborhood Hits	1014	Shared Neighborhood Hits	55
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 778)	NC score	0.077637 (rank : 640)
Query Neighborhood Hits	467	Target Neighborhood Hits	1000	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.081533 (rank : 595)
Query Neighborhood Hits	467	Target Neighborhood Hits	907	Shared Neighborhood Hits	53
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RSNL2_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.147378 (rank : 469)
Query Neighborhood Hits	467	Target Neighborhood Hits	129	Shared Neighborhood Hits	92
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

RUSC2_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.086247 (rank : 573)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.080350 (rank : 610)
Query Neighborhood Hits	467	Target Neighborhood Hits	701	Shared Neighborhood Hits	47
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.079474 (rank : 619)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	47
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SAMN1_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.085384 (rank : 578)
Query Neighborhood Hits	467	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.081896 (rank : 593)
Query Neighborhood Hits	467	Target Neighborhood Hits	69	Shared Neighborhood Hits	45
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.085936 (rank : 575)
Query Neighborhood Hits	467	Target Neighborhood Hits	263	Shared Neighborhood Hits	62
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.097797 (rank : 550)
Query Neighborhood Hits	467	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.100078 (rank : 543)
Query Neighborhood Hits	467	Target Neighborhood Hits	89	Shared Neighborhood Hits	35
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.121465 (rank : 503)
Query Neighborhood Hits	467	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.127056 (rank : 495)
Query Neighborhood Hits	467	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.061264 (rank : 805)
Query Neighborhood Hits	467	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.070056 (rank : 748)
Query Neighborhood Hits	467	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.055943 (rank : 846)
Query Neighborhood Hits	467	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.076246 (rank : 661)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.057652 (rank : 836)
Query Neighborhood Hits	467	Target Neighborhood Hits	326	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.070333 (rank : 746)
Query Neighborhood Hits	467	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.076873 (rank : 648)
Query Neighborhood Hits	467	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.095949 (rank : 552)
Query Neighborhood Hits	467	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.098334 (rank : 549)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.106384 (rank : 526)
Query Neighborhood Hits	467	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 801)	NC score	0.105632 (rank : 529)
Query Neighborhood Hits	467	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.103613 (rank : 532)
Query Neighborhood Hits	467	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 803)	NC score	0.102759 (rank : 535)
Query Neighborhood Hits	467	Target Neighborhood Hits	144	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.099421 (rank : 546)
Query Neighborhood Hits	467	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.108470 (rank : 524)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.089213 (rank : 565)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.091489 (rank : 562)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.102293 (rank : 537)
Query Neighborhood Hits	467	Target Neighborhood Hits	164	Shared Neighborhood Hits	48
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.106007 (rank : 527)
Query Neighborhood Hits	467	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.168835 (rank : 435)
Query Neighborhood Hits	467	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 811)	NC score	0.171676 (rank : 431)
Query Neighborhood Hits	467	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.153589 (rank : 455)
Query Neighborhood Hits	467	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.155299 (rank : 452)
Query Neighborhood Hits	467	Target Neighborhood Hits	88	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.193569 (rank : 412)
Query Neighborhood Hits	467	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.190365 (rank : 416)
Query Neighborhood Hits	467	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.204258 (rank : 404)
Query Neighborhood Hits	467	Target Neighborhood Hits	139	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.204726 (rank : 402)
Query Neighborhood Hits	467	Target Neighborhood Hits	136	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS2_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.051217 (rank : 859)
Query Neighborhood Hits	467	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 819)	NC score	0.050168 (rank : 865)
Query Neighborhood Hits	467	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.050453 (rank : 863)
Query Neighborhood Hits	467	Target Neighborhood Hits	126	Shared Neighborhood Hits	39
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 821)	NC score	0.050982 (rank : 860)
Query Neighborhood Hits	467	Target Neighborhood Hits	146	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.071764 (rank : 729)
Query Neighborhood Hits	467	Target Neighborhood Hits	154	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SRMS_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.115207 (rank : 516)
Query Neighborhood Hits	467	Target Neighborhood Hits	946	Shared Neighborhood Hits	95
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

STYK1_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.077254 (rank : 646)
Query Neighborhood Hits	467	Target Neighborhood Hits	786	Shared Neighborhood Hits	51
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 825)	NC score	0.075359 (rank : 684)
Query Neighborhood Hits	467	Target Neighborhood Hits	779	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK1_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.052309 (rank : 855)
Query Neighborhood Hits	467	Target Neighborhood Hits	1734	Shared Neighborhood Hits	86
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.052089 (rank : 856)
Query Neighborhood Hits	467	Target Neighborhood Hits	1720	Shared Neighborhood Hits	86
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TENS4_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.056102 (rank : 845)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TESK1_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.060102 (rank : 813)
Query Neighborhood Hits	467	Target Neighborhood Hits	864	Shared Neighborhood Hits	56
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.059738 (rank : 815)
Query Neighborhood Hits	467	Target Neighborhood Hits	862	Shared Neighborhood Hits	54
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.064522 (rank : 786)
Query Neighborhood Hits	467	Target Neighborhood Hits	851	Shared Neighborhood Hits	53
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.063121 (rank : 796)
Query Neighborhood Hits	467	Target Neighborhood Hits	833	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TGFR1_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.059652 (rank : 816)
Query Neighborhood Hits	467	Target Neighborhood Hits	755	Shared Neighborhood Hits	51
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 834)	NC score	0.059570 (rank : 819)
Query Neighborhood Hits	467	Target Neighborhood Hits	753	Shared Neighborhood Hits	51
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.101333 (rank : 542)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	28
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.102784 (rank : 534)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE1_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.075695 (rank : 674)
Query Neighborhood Hits	467	Target Neighborhood Hits	1241	Shared Neighborhood Hits	60
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.075536 (rank : 677)
Query Neighborhood Hits	467	Target Neighborhood Hits	1266	Shared Neighborhood Hits	60
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.075844 (rank : 673)
Query Neighborhood Hits	467	Target Neighborhood Hits	1192	Shared Neighborhood Hits	63
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.075511 (rank : 679)
Query Neighborhood Hits	467	Target Neighborhood Hits	1204	Shared Neighborhood Hits	63
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNK1_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.082855 (rank : 587)
Query Neighborhood Hits	467	Target Neighborhood Hits	815	Shared Neighborhood Hits	59
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.082355 (rank : 590)
Query Neighborhood Hits	467	Target Neighborhood Hits	806	Shared Neighborhood Hits	58
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.066985 (rank : 767)
Query Neighborhood Hits	467	Target Neighborhood Hits	605	Shared Neighborhood Hits	48
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.063932 (rank : 790)
Query Neighborhood Hits	467	Target Neighborhood Hits	618	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.066954 (rank : 768)
Query Neighborhood Hits	467	Target Neighborhood Hits	1580	Shared Neighborhood Hits	106
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TRPC3_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.054480 (rank : 851)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC6_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.068207 (rank : 757)
Query Neighborhood Hits	467	Target Neighborhood Hits	171	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPV1_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.136134 (rank : 485)
Query Neighborhood Hits	467	Target Neighborhood Hits	184	Shared Neighborhood Hits	128
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.148639 (rank : 464)
Query Neighborhood Hits	467	Target Neighborhood Hits	189	Shared Neighborhood Hits	134
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV2_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.122520 (rank : 502)
Query Neighborhood Hits	467	Target Neighborhood Hits	130	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.088738 (rank : 567)
Query Neighborhood Hits	467	Target Neighborhood Hits	111	Shared Neighborhood Hits	80
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV3_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.149686 (rank : 461)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV4_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.065310 (rank : 783)
Query Neighborhood Hits	467	Target Neighborhood Hits	150	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.058297 (rank : 829)
Query Neighborhood Hits	467	Target Neighborhood Hits	117	Shared Neighborhood Hits	65
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV6_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.314695 (rank : 340)
Query Neighborhood Hits	467	Target Neighborhood Hits	262	Shared Neighborhood Hits	200
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV6_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.382840 (rank : 293)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	223
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

TYK2_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.068922 (rank : 753)
Query Neighborhood Hits	467	Target Neighborhood Hits	841	Shared Neighborhood Hits	52
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.069281 (rank : 751)
Query Neighborhood Hits	467	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.074689 (rank : 695)
Query Neighborhood Hits	467	Target Neighborhood Hits	995	Shared Neighborhood Hits	51
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.075035 (rank : 688)
Query Neighborhood Hits	467	Target Neighborhood Hits	1007	Shared Neighborhood Hits	52
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.076357 (rank : 660)
Query Neighborhood Hits	467	Target Neighborhood Hits	981	Shared Neighborhood Hits	52
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 862)	NC score	0.076638 (rank : 652)
Query Neighborhood Hits	467	Target Neighborhood Hits	988	Shared Neighborhood Hits	54
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VGFR1_HUMAN
θ value	θ > 10 (rank : 863)	NC score	0.063392 (rank : 793)
Query Neighborhood Hits	467	Target Neighborhood Hits	1109	Shared Neighborhood Hits	52
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 864)	NC score	0.063082 (rank : 797)
Query Neighborhood Hits	467	Target Neighborhood Hits	1118	Shared Neighborhood Hits	51
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.062566 (rank : 798)
Query Neighborhood Hits	467	Target Neighborhood Hits	1103	Shared Neighborhood Hits	51
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 866)	NC score	0.063382 (rank : 794)
Query Neighborhood Hits	467	Target Neighborhood Hits	1089	Shared Neighborhood Hits	51
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 867)	NC score	0.066426 (rank : 776)
Query Neighborhood Hits	467	Target Neighborhood Hits	1037	Shared Neighborhood Hits	52
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 868)	NC score	0.066435 (rank : 775)
Query Neighborhood Hits	467	Target Neighborhood Hits	1056	Shared Neighborhood Hits	51
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WNK2_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.054646 (rank : 850)
Query Neighborhood Hits	467	Target Neighborhood Hits	1407	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

YSK4_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.050106 (rank : 867)
Query Neighborhood Hits	467	Target Neighborhood Hits	921	Shared Neighborhood Hits	59
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.095406 (rank : 555)
Query Neighborhood Hits	467	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.095900 (rank : 553)
Query Neighborhood Hits	467	Target Neighborhood Hits	905	Shared Neighborhood Hits	73
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

OSTF1_MOUSE
NC score	0.999962 (rank : 1)	θ value	6.44497e-115 (rank : 1)
Query Neighborhood Hits	467	Target Neighborhood Hits	467	Shared Neighborhood Hits	467
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OSTF1_HUMAN
NC score	0.995459 (rank : 2)	θ value	2.6227e-108 (rank : 2)
Query Neighborhood Hits	467	Target Neighborhood Hits	466	Shared Neighborhood Hits	458
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ANKR2_MOUSE
NC score	0.704562 (rank : 3)	θ value	1.133e-10 (rank : 8)
Query Neighborhood Hits	467	Target Neighborhood Hits	312	Shared Neighborhood Hits	256
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

PSD10_HUMAN
NC score	0.704525 (rank : 4)	θ value	1.99992e-07 (rank : 61)
Query Neighborhood Hits	467	Target Neighborhood Hits	301	Shared Neighborhood Hits	258
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

PSD10_MOUSE
NC score	0.704271 (rank : 5)	θ value	2.61198e-07 (rank : 67)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	257
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANKR2_HUMAN
NC score	0.701545 (rank : 6)	θ value	3.89403e-11 (rank : 7)
Query Neighborhood Hits	467	Target Neighborhood Hits	321	Shared Neighborhood Hits	256
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANR29_HUMAN
NC score	0.698380 (rank : 7)	θ value	1.63604e-09 (rank : 17)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	254
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR39_MOUSE
NC score	0.697969 (rank : 8)	θ value	1.17247e-07 (rank : 53)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	249
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR23_MOUSE
NC score	0.697656 (rank : 9)	θ value	4.76016e-09 (rank : 22)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	257
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ANR23_HUMAN
NC score	0.693847 (rank : 10)	θ value	1.06045e-08 (rank : 27)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	255
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANR39_HUMAN
NC score	0.693829 (rank : 11)	θ value	2.44474e-05 (rank : 145)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	250
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANKR6_HUMAN
NC score	0.691446 (rank : 12)	θ value	6.87365e-08 (rank : 45)
Query Neighborhood Hits	467	Target Neighborhood Hits	439	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANKR1_MOUSE
NC score	0.690091 (rank : 13)	θ value	1.99992e-07 (rank : 60)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	254
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANKR1_HUMAN
NC score	0.687780 (rank : 14)	θ value	7.59969e-07 (rank : 76)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	252
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANR50_HUMAN
NC score	0.685090 (rank : 15)	θ value	3.08544e-08 (rank : 36)
Query Neighborhood Hits	467	Target Neighborhood Hits	361	Shared Neighborhood Hits	258
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

TNKS2_HUMAN
NC score	0.683713 (rank : 16)	θ value	9.59137e-10 (rank : 16)
Query Neighborhood Hits	467	Target Neighborhood Hits	361	Shared Neighborhood Hits	258
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ACBD6_MOUSE
NC score	0.683673 (rank : 17)	θ value	1.74796e-11 (rank : 5)
Query Neighborhood Hits	467	Target Neighborhood Hits	305	Shared Neighborhood Hits	251
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

MTPN_MOUSE
NC score	0.683119 (rank : 18)	θ value	2.44474e-05 (rank : 146)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	241
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

INVS_HUMAN
NC score	0.682712 (rank : 19)	θ value	4.0297e-08 (rank : 38)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

TNKS1_HUMAN
NC score	0.682511 (rank : 20)	θ value	3.29651e-10 (rank : 11)
Query Neighborhood Hits	467	Target Neighborhood Hits	477	Shared Neighborhood Hits	262
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR49_MOUSE
NC score	0.681981 (rank : 21)	θ value	7.1131e-05 (rank : 164)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

MTPN_HUMAN
NC score	0.681148 (rank : 22)	θ value	7.1131e-05 (rank : 166)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	241
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

ANR44_HUMAN
NC score	0.680966 (rank : 23)	θ value	6.21693e-09 (rank : 23)
Query Neighborhood Hits	467	Target Neighborhood Hits	318	Shared Neighborhood Hits	259
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ANR16_HUMAN
NC score	0.679701 (rank : 24)	θ value	0.000158464 (rank : 183)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	254
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR28_MOUSE
NC score	0.678683 (rank : 25)	θ value	1.17247e-07 (rank : 52)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	259
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ACBD6_HUMAN
NC score	0.677747 (rank : 26)	θ value	2.28291e-11 (rank : 6)
Query Neighborhood Hits	467	Target Neighborhood Hits	304	Shared Neighborhood Hits	249
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANR49_HUMAN
NC score	0.677532 (rank : 27)	θ value	0.00020696 (rank : 200)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ANR28_HUMAN
NC score	0.677447 (rank : 28)	θ value	1.17247e-07 (rank : 51)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	259
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

GABP2_MOUSE
NC score	0.675341 (rank : 29)	θ value	1.29631e-06 (rank : 91)
Query Neighborhood Hits	467	Target Neighborhood Hits	429	Shared Neighborhood Hits	259
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

FANK1_MOUSE
NC score	0.675306 (rank : 30)	θ value	0.00134147 (rank : 237)
Query Neighborhood Hits	467	Target Neighborhood Hits	325	Shared Neighborhood Hits	253
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

ANKR5_HUMAN
NC score	0.674976 (rank : 31)	θ value	2.21117e-06 (rank : 99)
Query Neighborhood Hits	467	Target Neighborhood Hits	297	Shared Neighborhood Hits	255
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

INVS_MOUSE
NC score	0.674766 (rank : 32)	θ value	4.0297e-08 (rank : 39)
Query Neighborhood Hits	467	Target Neighborhood Hits	609	Shared Neighborhood Hits	261
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ANKR5_MOUSE
NC score	0.673696 (rank : 33)	θ value	4.92598e-06 (rank : 119)
Query Neighborhood Hits	467	Target Neighborhood Hits	298	Shared Neighborhood Hits	254
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

FANK1_HUMAN
NC score	0.673311 (rank : 34)	θ value	0.000786445 (rank : 227)
Query Neighborhood Hits	467	Target Neighborhood Hits	326	Shared Neighborhood Hits	252
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

GABP2_HUMAN
NC score	0.673008 (rank : 35)	θ value	2.21117e-06 (rank : 101)
Query Neighborhood Hits	467	Target Neighborhood Hits	454	Shared Neighborhood Hits	258
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ASB10_HUMAN
NC score	0.670843 (rank : 36)	θ value	1.29631e-06 (rank : 89)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	251
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANR52_MOUSE
NC score	0.670053 (rank : 37)	θ value	6.87365e-08 (rank : 47)
Query Neighborhood Hits	467	Target Neighborhood Hits	318	Shared Neighborhood Hits	259
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR52_HUMAN
NC score	0.669984 (rank : 38)	θ value	6.87365e-08 (rank : 46)
Query Neighborhood Hits	467	Target Neighborhood Hits	322	Shared Neighborhood Hits	259
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

MYPT1_MOUSE
NC score	0.669952 (rank : 39)	θ value	6.87365e-08 (rank : 50)
Query Neighborhood Hits	467	Target Neighborhood Hits	539	Shared Neighborhood Hits	257
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ASB10_MOUSE
NC score	0.669398 (rank : 40)	θ value	6.43352e-06 (rank : 124)
Query Neighborhood Hits	467	Target Neighborhood Hits	301	Shared Neighborhood Hits	256
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

GABP3_MOUSE
NC score	0.668323 (rank : 41)	θ value	7.1131e-05 (rank : 165)
Query Neighborhood Hits	467	Target Neighborhood Hits	330	Shared Neighborhood Hits	254
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ASB2_HUMAN
NC score	0.668061 (rank : 42)	θ value	1.17247e-07 (rank : 54)
Query Neighborhood Hits	467	Target Neighborhood Hits	309	Shared Neighborhood Hits	255
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANK1_HUMAN
NC score	0.666674 (rank : 43)	θ value	4.45536e-07 (rank : 71)
Query Neighborhood Hits	467	Target Neighborhood Hits	416	Shared Neighborhood Hits	260
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ASB13_MOUSE
NC score	0.666581 (rank : 44)	θ value	5.44631e-05 (rank : 157)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

CDN2C_MOUSE
NC score	0.666492 (rank : 45)	θ value	6.43352e-06 (rank : 125)
Query Neighborhood Hits	467	Target Neighborhood Hits	270	Shared Neighborhood Hits	242
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ASB13_HUMAN
NC score	0.665957 (rank : 46)	θ value	5.44631e-05 (rank : 156)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	252
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

SHAN1_HUMAN
NC score	0.665546 (rank : 47)	θ value	0.00035302 (rank : 215)
Query Neighborhood Hits	467	Target Neighborhood Hits	1041	Shared Neighborhood Hits	370
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ANK1_MOUSE
NC score	0.664531 (rank : 48)	θ value	7.59969e-07 (rank : 75)
Query Neighborhood Hits	467	Target Neighborhood Hits	430	Shared Neighborhood Hits	259
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

CDN2C_HUMAN
NC score	0.664519 (rank : 49)	θ value	2.88788e-06 (rank : 106)
Query Neighborhood Hits	467	Target Neighborhood Hits	262	Shared Neighborhood Hits	240
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CSKI2_MOUSE
NC score	0.664353 (rank : 50)	θ value	9.92553e-07 (rank : 86)
Query Neighborhood Hits	467	Target Neighborhood Hits	812	Shared Neighborhood Hits	302
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ASB2_MOUSE
NC score	0.664117 (rank : 51)	θ value	2.61198e-07 (rank : 64)
Query Neighborhood Hits	467	Target Neighborhood Hits	321	Shared Neighborhood Hits	254
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANR42_MOUSE
NC score	0.663471 (rank : 52)	θ value	0.00665767 (rank : 285)
Query Neighborhood Hits	467	Target Neighborhood Hits	334	Shared Neighborhood Hits	253
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANKS3_MOUSE
NC score	0.663341 (rank : 53)	θ value	3.19293e-05 (rank : 150)
Query Neighborhood Hits	467	Target Neighborhood Hits	355	Shared Neighborhood Hits	251
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ASB3_MOUSE
NC score	0.663233 (rank : 54)	θ value	0.00175202 (rank : 242)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	256
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANRA2_HUMAN
NC score	0.662428 (rank : 55)	θ value	9.29e-05 (rank : 170)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	250
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB3_HUMAN
NC score	0.661906 (rank : 56)	θ value	0.00390308 (rank : 266)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	256
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

MYPT2_HUMAN
NC score	0.661599 (rank : 57)	θ value	1.06045e-08 (rank : 30)
Query Neighborhood Hits	467	Target Neighborhood Hits	707	Shared Neighborhood Hits	260
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

TRPA1_MOUSE
NC score	0.660811 (rank : 58)	θ value	3.41135e-07 (rank : 70)
Query Neighborhood Hits	467	Target Neighborhood Hits	343	Shared Neighborhood Hits	255
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANKS3_HUMAN
NC score	0.660391 (rank : 59)	θ value	3.19293e-05 (rank : 149)
Query Neighborhood Hits	467	Target Neighborhood Hits	355	Shared Neighborhood Hits	250
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

CSKI2_HUMAN
NC score	0.660343 (rank : 60)	θ value	9.92553e-07 (rank : 85)
Query Neighborhood Hits	467	Target Neighborhood Hits	747	Shared Neighborhood Hits	299
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ANRA2_MOUSE
NC score	0.659878 (rank : 61)	θ value	0.000121331 (rank : 176)
Query Neighborhood Hits	467	Target Neighborhood Hits	287	Shared Neighborhood Hits	248
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

PP16A_MOUSE
NC score	0.659765 (rank : 62)	θ value	8.40245e-06 (rank : 131)
Query Neighborhood Hits	467	Target Neighborhood Hits	318	Shared Neighborhood Hits	253
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ANKS1_HUMAN
NC score	0.659714 (rank : 63)	θ value	1.38499e-08 (rank : 31)
Query Neighborhood Hits	467	Target Neighborhood Hits	438	Shared Neighborhood Hits	265
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANK3_HUMAN
NC score	0.658985 (rank : 64)	θ value	3.08544e-08 (rank : 35)
Query Neighborhood Hits	467	Target Neighborhood Hits	853	Shared Neighborhood Hits	262
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

BARD1_HUMAN
NC score	0.658896 (rank : 65)	θ value	4.0297e-08 (rank : 37)
Query Neighborhood Hits	467	Target Neighborhood Hits	427	Shared Neighborhood Hits	254
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ANR10_MOUSE
NC score	0.657591 (rank : 66)	θ value	1.09739e-05 (rank : 134)
Query Neighborhood Hits	467	Target Neighborhood Hits	273	Shared Neighborhood Hits	237
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

TRPA1_HUMAN
NC score	0.657548 (rank : 67)	θ value	2.88788e-06 (rank : 112)
Query Neighborhood Hits	467	Target Neighborhood Hits	339	Shared Neighborhood Hits	255
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ASB8_HUMAN
NC score	0.657367 (rank : 68)	θ value	0.00298849 (rank : 259)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	250
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

PP16A_HUMAN
NC score	0.656995 (rank : 69)	θ value	7.1131e-05 (rank : 169)
Query Neighborhood Hits	467	Target Neighborhood Hits	340	Shared Neighborhood Hits	250
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ANKS6_HUMAN
NC score	0.656943 (rank : 70)	θ value	2.44474e-05 (rank : 143)
Query Neighborhood Hits	467	Target Neighborhood Hits	411	Shared Neighborhood Hits	258
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

BARD1_MOUSE
NC score	0.656556 (rank : 71)	θ value	6.87365e-08 (rank : 48)
Query Neighborhood Hits	467	Target Neighborhood Hits	411	Shared Neighborhood Hits	251
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ASB8_MOUSE
NC score	0.656536 (rank : 72)	θ value	0.00869519 (rank : 293)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	250
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ANR42_HUMAN
NC score	0.656032 (rank : 73)	θ value	0.47712 (rank : 402)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	253
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB7_MOUSE
NC score	0.655441 (rank : 74)	θ value	0.00509761 (rank : 276)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	250
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ANKS6_MOUSE
NC score	0.655234 (rank : 75)	θ value	0.000158464 (rank : 182)
Query Neighborhood Hits	467	Target Neighborhood Hits	435	Shared Neighborhood Hits	258
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ASB7_HUMAN
NC score	0.655146 (rank : 76)	θ value	0.00509761 (rank : 275)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	250
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

MYPT1_HUMAN
NC score	0.654675 (rank : 77)	θ value	6.87365e-08 (rank : 49)
Query Neighborhood Hits	467	Target Neighborhood Hits	723	Shared Neighborhood Hits	260
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANR10_HUMAN
NC score	0.654281 (rank : 78)	θ value	3.19293e-05 (rank : 151)
Query Neighborhood Hits	467	Target Neighborhood Hits	289	Shared Neighborhood Hits	238
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

MIB1_HUMAN
NC score	0.653929 (rank : 79)	θ value	8.11959e-09 (rank : 25)
Query Neighborhood Hits	467	Target Neighborhood Hits	470	Shared Neighborhood Hits	256
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
NC score	0.653727 (rank : 80)	θ value	8.11959e-09 (rank : 26)
Query Neighborhood Hits	467	Target Neighborhood Hits	471	Shared Neighborhood Hits	256
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

ASB11_MOUSE
NC score	0.652698 (rank : 81)	θ value	1.69304e-06 (rank : 97)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	236
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

EHMT1_HUMAN
NC score	0.650640 (rank : 82)	θ value	9.59137e-10 (rank : 15)
Query Neighborhood Hits	467	Target Neighborhood Hits	417	Shared Neighborhood Hits	258
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

RFXK_HUMAN
NC score	0.650527 (rank : 83)	θ value	0.0961366 (rank : 370)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	242
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

ASB9_HUMAN
NC score	0.650265 (rank : 84)	θ value	1.87187e-05 (rank : 140)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	232
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

ANKS1_MOUSE
NC score	0.650211 (rank : 85)	θ value	3.41135e-07 (rank : 69)
Query Neighborhood Hits	467	Target Neighborhood Hits	453	Shared Neighborhood Hits	265
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ASB11_HUMAN
NC score	0.649854 (rank : 86)	θ value	7.59969e-07 (rank : 77)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	236
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

CSKI1_HUMAN
NC score	0.649616 (rank : 87)	θ value	1.80886e-08 (rank : 33)
Query Neighborhood Hits	467	Target Neighborhood Hits	997	Shared Neighborhood Hits	301
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASB5_HUMAN
NC score	0.649578 (rank : 88)	θ value	2.21117e-06 (rank : 100)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	246
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

PP16B_HUMAN
NC score	0.649577 (rank : 89)	θ value	0.000461057 (rank : 221)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	254
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

PA2G6_MOUSE
NC score	0.649509 (rank : 90)	θ value	3.19293e-05 (rank : 153)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	249
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

PP16B_MOUSE
NC score	0.648923 (rank : 91)	θ value	0.000461057 (rank : 222)
Query Neighborhood Hits	467	Target Neighborhood Hits	302	Shared Neighborhood Hits	252
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ASZ1_HUMAN
NC score	0.648778 (rank : 92)	θ value	0.00665767 (rank : 286)
Query Neighborhood Hits	467	Target Neighborhood Hits	341	Shared Neighborhood Hits	249
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

RFXK_MOUSE
NC score	0.648763 (rank : 93)	θ value	0.000158464 (rank : 191)
Query Neighborhood Hits	467	Target Neighborhood Hits	273	Shared Neighborhood Hits	243
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

CSKI1_MOUSE
NC score	0.647785 (rank : 94)	θ value	1.38499e-08 (rank : 32)
Query Neighborhood Hits	467	Target Neighborhood Hits	1031	Shared Neighborhood Hits	298
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASZ1_MOUSE
NC score	0.646586 (rank : 95)	θ value	0.0563607 (rank : 350)
Query Neighborhood Hits	467	Target Neighborhood Hits	319	Shared Neighborhood Hits	249
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ASB5_MOUSE
NC score	0.644861 (rank : 96)	θ value	9.29e-05 (rank : 171)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	235
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ASB9_MOUSE
NC score	0.644406 (rank : 97)	θ value	2.88788e-06 (rank : 105)
Query Neighborhood Hits	467	Target Neighborhood Hits	257	Shared Neighborhood Hits	226
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

MIB2_HUMAN
NC score	0.641450 (rank : 98)	θ value	6.43352e-06 (rank : 127)
Query Neighborhood Hits	467	Target Neighborhood Hits	438	Shared Neighborhood Hits	257
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

CT086_HUMAN
NC score	0.641170 (rank : 99)	θ value	0.00869519 (rank : 295)
Query Neighborhood Hits	467	Target Neighborhood Hits	277	Shared Neighborhood Hits	244
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

BCL3_HUMAN
NC score	0.641019 (rank : 100)	θ value	0.00390308 (rank : 269)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	249
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

PA2G6_HUMAN
NC score	0.640991 (rank : 101)	θ value	0.00035302 (rank : 214)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	247
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

MIB2_MOUSE
NC score	0.640338 (rank : 102)	θ value	4.1701e-05 (rank : 155)
Query Neighborhood Hits	467	Target Neighborhood Hits	409	Shared Neighborhood Hits	251
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

BCL3_MOUSE
NC score	0.637907 (rank : 103)	θ value	0.00298849 (rank : 260)
Query Neighborhood Hits	467	Target Neighborhood Hits	388	Shared Neighborhood Hits	250
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

EHMT2_HUMAN
NC score	0.637119 (rank : 104)	θ value	2.36244e-08 (rank : 34)
Query Neighborhood Hits	467	Target Neighborhood Hits	498	Shared Neighborhood Hits	256
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

IASPP_HUMAN
NC score	0.636867 (rank : 105)	θ value	0.163984 (rank : 388)
Query Neighborhood Hits	467	Target Neighborhood Hits	688	Shared Neighborhood Hits	376
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ASB15_HUMAN
NC score	0.636043 (rank : 106)	θ value	0.00035302 (rank : 212)
Query Neighborhood Hits	467	Target Neighborhood Hits	305	Shared Neighborhood Hits	248
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB16_HUMAN
NC score	0.635138 (rank : 107)	θ value	0.00298849 (rank : 258)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	241
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ANR22_HUMAN
NC score	0.634950 (rank : 108)	θ value	0.279714 (rank : 392)
Query Neighborhood Hits	467	Target Neighborhood Hits	243	Shared Neighborhood Hits	227
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ASB16_MOUSE
NC score	0.632440 (rank : 109)	θ value	0.0736092 (rank : 356)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	247
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ANKR7_HUMAN
NC score	0.631385 (rank : 110)	θ value	0.0736092 (rank : 354)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	249
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANR32_HUMAN
NC score	0.631298 (rank : 111)	θ value	0.00102713 (rank : 231)
Query Neighborhood Hits	467	Target Neighborhood Hits	270	Shared Neighborhood Hits	235
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR32_MOUSE
NC score	0.627114 (rank : 112)	θ value	0.000158464 (rank : 184)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	236
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

EHMT2_MOUSE
NC score	0.626626 (rank : 113)	θ value	6.21693e-09 (rank : 24)
Query Neighborhood Hits	467	Target Neighborhood Hits	750	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ASB15_MOUSE
NC score	0.626592 (rank : 114)	θ value	0.00228821 (rank : 250)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	245
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

RN5A_HUMAN
NC score	0.626587 (rank : 115)	θ value	0.00298849 (rank : 265)
Query Neighborhood Hits	467	Target Neighborhood Hits	608	Shared Neighborhood Hits	266
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

AN36B_HUMAN
NC score	0.623228 (rank : 116)	θ value	0.00298849 (rank : 257)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	246
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ANK2_HUMAN
NC score	0.622774 (rank : 117)	θ value	2.13673e-09 (rank : 19)
Query Neighborhood Hits	467	Target Neighborhood Hits	1615	Shared Neighborhood Hits	285
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CDN2D_HUMAN
NC score	0.622715 (rank : 118)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	467	Target Neighborhood Hits	268	Shared Neighborhood Hits	238
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ANR11_HUMAN
NC score	0.621774 (rank : 119)	θ value	5.62301e-10 (rank : 12)
Query Neighborhood Hits	467	Target Neighborhood Hits	1289	Shared Neighborhood Hits	276
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ASB4_MOUSE
NC score	0.620978 (rank : 120)	θ value	0.00390308 (rank : 267)
Query Neighborhood Hits	467	Target Neighborhood Hits	265	Shared Neighborhood Hits	232
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB1_HUMAN
NC score	0.620606 (rank : 121)	θ value	0.0113563 (rank : 301)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	246
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ASB4_HUMAN
NC score	0.620083 (rank : 122)	θ value	0.0193708 (rank : 317)
Query Neighborhood Hits	467	Target Neighborhood Hits	264	Shared Neighborhood Hits	232
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB14_MOUSE
NC score	0.619580 (rank : 123)	θ value	0.0252991 (rank : 325)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	249
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB1_MOUSE
NC score	0.617776 (rank : 124)	θ value	0.0736092 (rank : 357)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	246
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

CDN2D_MOUSE
NC score	0.616405 (rank : 125)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	237
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ANR46_HUMAN
NC score	0.615410 (rank : 126)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	467	Target Neighborhood Hits	281	Shared Neighborhood Hits	247
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ASB12_HUMAN
NC score	0.614667 (rank : 127)	θ value	0.0431538 (rank : 345)
Query Neighborhood Hits	467	Target Neighborhood Hits	263	Shared Neighborhood Hits	239
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASPP1_HUMAN
NC score	0.614327 (rank : 128)	θ value	0.00390308 (rank : 268)
Query Neighborhood Hits	467	Target Neighborhood Hits	956	Shared Neighborhood Hits	381
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

USH1G_HUMAN
NC score	0.613542 (rank : 129)	θ value	0.000270298 (rank : 207)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	242
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

IKBA_HUMAN
NC score	0.613499 (rank : 130)	θ value	0.0563607 (rank : 352)
Query Neighborhood Hits	467	Target Neighborhood Hits	280	Shared Neighborhood Hits	239
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

USH1G_MOUSE
NC score	0.613442 (rank : 131)	θ value	0.000270298 (rank : 208)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	242
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANR35_HUMAN
NC score	0.613381 (rank : 132)	θ value	0.00020696 (rank : 199)
Query Neighborhood Hits	467	Target Neighborhood Hits	784	Shared Neighborhood Hits	262
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

IKBE_MOUSE
NC score	0.612077 (rank : 133)	θ value	0.00869519 (rank : 296)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	245
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

ASB12_MOUSE
NC score	0.611708 (rank : 134)	θ value	0.62314 (rank : 408)
Query Neighborhood Hits	467	Target Neighborhood Hits	261	Shared Neighborhood Hits	234
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ANS4B_HUMAN
NC score	0.608967 (rank : 135)	θ value	0.00509761 (rank : 274)
Query Neighborhood Hits	467	Target Neighborhood Hits	289	Shared Neighborhood Hits	242
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

AN36A_HUMAN
NC score	0.608369 (rank : 136)	θ value	0.00665767 (rank : 283)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	239
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANR46_MOUSE
NC score	0.607732 (rank : 137)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	467	Target Neighborhood Hits	274	Shared Neighborhood Hits	242
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANKY2_HUMAN
NC score	0.603764 (rank : 138)	θ value	0.000270298 (rank : 203)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR37_HUMAN
NC score	0.603596 (rank : 139)	θ value	0.00175202 (rank : 241)
Query Neighborhood Hits	467	Target Neighborhood Hits	247	Shared Neighborhood Hits	227
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR12_HUMAN
NC score	0.603077 (rank : 140)	θ value	2.0648e-12 (rank : 3)
Query Neighborhood Hits	467	Target Neighborhood Hits	1081	Shared Neighborhood Hits	264
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

RN5A_MOUSE
NC score	0.601357 (rank : 141)	θ value	0.000786445 (rank : 228)
Query Neighborhood Hits	467	Target Neighborhood Hits	899	Shared Neighborhood Hits	276
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

IKBA_MOUSE
NC score	0.599368 (rank : 142)	θ value	2.36792 (rank : 438)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	240
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

ANS4B_MOUSE
NC score	0.598999 (rank : 143)	θ value	0.00869519 (rank : 292)
Query Neighborhood Hits	467	Target Neighborhood Hits	294	Shared Neighborhood Hits	240
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASPP1_MOUSE
NC score	0.598813 (rank : 144)	θ value	0.00509761 (rank : 277)
Query Neighborhood Hits	467	Target Neighborhood Hits	1244	Shared Neighborhood Hits	387
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

POTE8_HUMAN
NC score	0.594197 (rank : 145)	θ value	0.125558 (rank : 380)
Query Neighborhood Hits	467	Target Neighborhood Hits	337	Shared Neighborhood Hits	249
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

IKBB_MOUSE
NC score	0.594108 (rank : 146)	θ value	0.00134147 (rank : 238)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	243
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

IKBE_HUMAN
NC score	0.593681 (rank : 147)	θ value	0.163984 (rank : 389)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	239
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

IKBB_HUMAN
NC score	0.592654 (rank : 148)	θ value	0.0113563 (rank : 306)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	244
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

ANR19_HUMAN
NC score	0.592488 (rank : 149)	θ value	0.813845 (rank : 415)
Query Neighborhood Hits	467	Target Neighborhood Hits	276	Shared Neighborhood Hits	244
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ZDH17_HUMAN
NC score	0.591979 (rank : 150)	θ value	3.77169e-06 (rank : 117)
Query Neighborhood Hits	467	Target Neighborhood Hits	334	Shared Neighborhood Hits	253
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

CTTB2_HUMAN
NC score	0.591388 (rank : 151)	θ value	1.43324e-05 (rank : 137)
Query Neighborhood Hits	467	Target Neighborhood Hits	1061	Shared Neighborhood Hits	268
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

ANR15_HUMAN
NC score	0.591002 (rank : 152)	θ value	2.44474e-05 (rank : 144)
Query Neighborhood Hits	467	Target Neighborhood Hits	478	Shared Neighborhood Hits	244
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ASPP2_HUMAN
NC score	0.590460 (rank : 153)	θ value	0.0113563 (rank : 302)
Query Neighborhood Hits	467	Target Neighborhood Hits	1156	Shared Neighborhood Hits	380
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ZDH17_MOUSE
NC score	0.588328 (rank : 154)	θ value	1.09739e-05 (rank : 136)
Query Neighborhood Hits	467	Target Neighborhood Hits	328	Shared Neighborhood Hits	252
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

BCOR_MOUSE
NC score	0.587945 (rank : 155)	θ value	0.00035302 (rank : 213)
Query Neighborhood Hits	467	Target Neighborhood Hits	521	Shared Neighborhood Hits	247
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ANR47_MOUSE
NC score	0.582028 (rank : 156)	θ value	0.000602161 (rank : 224)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	237
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

BCOR_HUMAN
NC score	0.581802 (rank : 157)	θ value	0.000461057 (rank : 217)
Query Neighborhood Hits	467	Target Neighborhood Hits	609	Shared Neighborhood Hits	252
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

ANFY1_MOUSE
NC score	0.581359 (rank : 158)	θ value	0.00102713 (rank : 230)
Query Neighborhood Hits	467	Target Neighborhood Hits	480	Shared Neighborhood Hits	254
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANKY2_MOUSE
NC score	0.580134 (rank : 159)	θ value	0.00035302 (rank : 209)
Query Neighborhood Hits	467	Target Neighborhood Hits	316	Shared Neighborhood Hits	234
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR37_MOUSE
NC score	0.578881 (rank : 160)	θ value	0.0113563 (rank : 298)
Query Neighborhood Hits	467	Target Neighborhood Hits	237	Shared Neighborhood Hits	218
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANFY1_HUMAN
NC score	0.578820 (rank : 161)	θ value	0.00665767 (rank : 284)
Query Neighborhood Hits	467	Target Neighborhood Hits	480	Shared Neighborhood Hits	254
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

IASPP_MOUSE
NC score	0.578517 (rank : 162)	θ value	0.0961366 (rank : 367)
Query Neighborhood Hits	467	Target Neighborhood Hits	1024	Shared Neighborhood Hits	384
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

KRIT1_MOUSE
NC score	0.577309 (rank : 163)	θ value	1.43324e-05 (rank : 138)
Query Neighborhood Hits	467	Target Neighborhood Hits	258	Shared Neighborhood Hits	216
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

KRIT1_HUMAN
NC score	0.568927 (rank : 164)	θ value	8.40245e-06 (rank : 130)
Query Neighborhood Hits	467	Target Neighborhood Hits	258	Shared Neighborhood Hits	208
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

ZDH13_HUMAN
NC score	0.567139 (rank : 165)	θ value	0.163984 (rank : 390)
Query Neighborhood Hits	467	Target Neighborhood Hits	322	Shared Neighborhood Hits	247
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ANR25_HUMAN
NC score	0.566292 (rank : 166)	θ value	4.92598e-06 (rank : 120)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	237
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ZDH13_MOUSE
NC score	0.565023 (rank : 167)	θ value	1.06291 (rank : 423)
Query Neighborhood Hits	467	Target Neighborhood Hits	329	Shared Neighborhood Hits	248
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

POT14_HUMAN
NC score	0.564325 (rank : 168)	θ value	0.00228821 (rank : 254)
Query Neighborhood Hits	467	Target Neighborhood Hits	403	Shared Neighborhood Hits	245
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

POT15_HUMAN
NC score	0.564102 (rank : 169)	θ value	0.00509761 (rank : 281)
Query Neighborhood Hits	467	Target Neighborhood Hits	893	Shared Neighborhood Hits	257
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

ANR21_HUMAN
NC score	0.563630 (rank : 170)	θ value	0.0148317 (rank : 313)
Query Neighborhood Hits	467	Target Neighborhood Hits	864	Shared Neighborhood Hits	257
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

ANR33_MOUSE
NC score	0.563244 (rank : 171)	θ value	0.00035302 (rank : 211)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR33_HUMAN
NC score	0.561453 (rank : 172)	θ value	0.000158464 (rank : 185)
Query Neighborhood Hits	467	Target Neighborhood Hits	215	Shared Neighborhood Hits	200
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR25_MOUSE
NC score	0.560087 (rank : 173)	θ value	1.69304e-06 (rank : 96)
Query Neighborhood Hits	467	Target Neighborhood Hits	398	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANR47_HUMAN
NC score	0.558566 (rank : 174)	θ value	0.0736092 (rank : 355)
Query Neighborhood Hits	467	Target Neighborhood Hits	369	Shared Neighborhood Hits	233
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ANR41_HUMAN
NC score	0.556653 (rank : 175)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	467	Target Neighborhood Hits	332	Shared Neighborhood Hits	228
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

SNCAP_HUMAN
NC score	0.553137 (rank : 176)	θ value	0.0736092 (rank : 362)
Query Neighborhood Hits	467	Target Neighborhood Hits	313	Shared Neighborhood Hits	219
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ASB6_HUMAN
NC score	0.552059 (rank : 177)	θ value	0.0961366 (rank : 365)
Query Neighborhood Hits	467	Target Neighborhood Hits	256	Shared Neighborhood Hits	219
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

NFKB1_HUMAN
NC score	0.544600 (rank : 178)	θ value	0.0148317 (rank : 315)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	246
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NFKB1_MOUSE
NC score	0.541902 (rank : 179)	θ value	0.0961366 (rank : 369)
Query Neighborhood Hits	467	Target Neighborhood Hits	300	Shared Neighborhood Hits	244
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

OSBL1_HUMAN
NC score	0.541319 (rank : 180)	θ value	2.61198e-07 (rank : 66)
Query Neighborhood Hits	467	Target Neighborhood Hits	368	Shared Neighborhood Hits	253
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

NFKB2_HUMAN
NC score	0.540407 (rank : 181)	θ value	0.00102713 (rank : 234)
Query Neighborhood Hits	467	Target Neighborhood Hits	325	Shared Neighborhood Hits	246
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR38_HUMAN
NC score	0.539508 (rank : 182)	θ value	0.0113563 (rank : 299)
Query Neighborhood Hits	467	Target Neighborhood Hits	443	Shared Neighborhood Hits	230
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

MPP8_HUMAN
NC score	0.535482 (rank : 183)	θ value	0.000121331 (rank : 177)
Query Neighborhood Hits	467	Target Neighborhood Hits	948	Shared Neighborhood Hits	243
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

ASB6_MOUSE
NC score	0.534939 (rank : 184)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	467	Target Neighborhood Hits	264	Shared Neighborhood Hits	221
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

CLPB_MOUSE
NC score	0.534763 (rank : 185)	θ value	0.0193708 (rank : 318)
Query Neighborhood Hits	467	Target Neighborhood Hits	289	Shared Neighborhood Hits	229
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

POT22_HUMAN
NC score	0.534682 (rank : 186)	θ value	0.00298849 (rank : 264)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	234
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

CD2A1_MOUSE
NC score	0.530583 (rank : 187)	θ value	0.279714 (rank : 394)
Query Neighborhood Hits	467	Target Neighborhood Hits	206	Shared Neighborhood Hits	192
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

OSBL1_MOUSE
NC score	0.530188 (rank : 188)	θ value	6.43352e-06 (rank : 128)
Query Neighborhood Hits	467	Target Neighborhood Hits	336	Shared Neighborhood Hits	251
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

A20A3_HUMAN
NC score	0.528349 (rank : 189)	θ value	7.1131e-05 (rank : 162)
Query Neighborhood Hits	467	Target Neighborhood Hits	692	Shared Neighborhood Hits	253
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A1_HUMAN
NC score	0.527164 (rank : 190)	θ value	7.1131e-05 (rank : 160)
Query Neighborhood Hits	467	Target Neighborhood Hits	698	Shared Neighborhood Hits	250
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A2_HUMAN
NC score	0.526913 (rank : 191)	θ value	7.1131e-05 (rank : 161)
Query Neighborhood Hits	467	Target Neighborhood Hits	716	Shared Neighborhood Hits	251
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A4_HUMAN
NC score	0.525076 (rank : 192)	θ value	7.1131e-05 (rank : 163)
Query Neighborhood Hits	467	Target Neighborhood Hits	710	Shared Neighborhood Hits	254
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

NFKB2_MOUSE
NC score	0.524720 (rank : 193)	θ value	0.0330416 (rank : 337)
Query Neighborhood Hits	467	Target Neighborhood Hits	326	Shared Neighborhood Hits	241
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR38_MOUSE
NC score	0.519219 (rank : 194)	θ value	0.0113563 (rank : 300)
Query Neighborhood Hits	467	Target Neighborhood Hits	512	Shared Neighborhood Hits	226
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

CD2AP_HUMAN
NC score	0.504901 (rank : 195)	θ value	1.53129e-07 (rank : 57)
Query Neighborhood Hits	467	Target Neighborhood Hits	315	Shared Neighborhood Hits	196
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NUD12_MOUSE
NC score	0.504387 (rank : 196)	θ value	7.1131e-05 (rank : 168)
Query Neighborhood Hits	467	Target Neighborhood Hits	243	Shared Neighborhood Hits	212
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

CD2AP_MOUSE
NC score	0.503180 (rank : 197)	θ value	7.59969e-07 (rank : 78)
Query Neighborhood Hits	467	Target Neighborhood Hits	336	Shared Neighborhood Hits	201
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ANR45_MOUSE
NC score	0.502011 (rank : 198)	θ value	0.0961366 (rank : 364)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	179
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

RAI14_HUMAN
NC score	0.500086 (rank : 199)	θ value	3.77169e-06 (rank : 114)
Query Neighborhood Hits	467	Target Neighborhood Hits	1367	Shared Neighborhood Hits	274
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

SH3K1_HUMAN
NC score	0.498031 (rank : 200)	θ value	8.40245e-06 (rank : 132)
Query Neighborhood Hits	467	Target Neighborhood Hits	341	Shared Neighborhood Hits	198
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.497978 (rank : 201)	θ value	8.40245e-06 (rank : 133)
Query Neighborhood Hits	467	Target Neighborhood Hits	332	Shared Neighborhood Hits	200
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ILK2_HUMAN
NC score	0.497429 (rank : 202)	θ value	5.81887e-07 (rank : 73)
Query Neighborhood Hits	467	Target Neighborhood Hits	848	Shared Neighborhood Hits	289
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

HECD1_HUMAN
NC score	0.491562 (rank : 203)	θ value	3.19293e-05 (rank : 152)
Query Neighborhood Hits	467	Target Neighborhood Hits	371	Shared Neighborhood Hits	244
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

GRB2_HUMAN
NC score	0.489704 (rank : 204)	θ value	1.133e-10 (rank : 9)
Query Neighborhood Hits	467	Target Neighborhood Hits	310	Shared Neighborhood Hits	203
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

CDN2B_MOUSE
NC score	0.489393 (rank : 205)	θ value	1.06291 (rank : 418)
Query Neighborhood Hits	467	Target Neighborhood Hits	201	Shared Neighborhood Hits	185
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

GRB2_MOUSE
NC score	0.489077 (rank : 206)	θ value	1.133e-10 (rank : 10)
Query Neighborhood Hits	467	Target Neighborhood Hits	312	Shared Neighborhood Hits	203
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF2_HUMAN
NC score	0.485877 (rank : 207)	θ value	2.88788e-06 (rank : 110)
Query Neighborhood Hits	467	Target Neighborhood Hits	229	Shared Neighborhood Hits	174
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ILK_MOUSE
NC score	0.484174 (rank : 208)	θ value	1.17247e-07 (rank : 55)
Query Neighborhood Hits	467	Target Neighborhood Hits	858	Shared Neighborhood Hits	288
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.483928 (rank : 209)	θ value	5.81887e-07 (rank : 72)
Query Neighborhood Hits	467	Target Neighborhood Hits	857	Shared Neighborhood Hits	289
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

VINEX_HUMAN
NC score	0.481012 (rank : 210)	θ value	1.87187e-05 (rank : 141)
Query Neighborhood Hits	467	Target Neighborhood Hits	270	Shared Neighborhood Hits	192
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ANR18_HUMAN
NC score	0.479269 (rank : 211)	θ value	0.125558 (rank : 373)
Query Neighborhood Hits	467	Target Neighborhood Hits	1106	Shared Neighborhood Hits	255
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR45_HUMAN
NC score	0.479191 (rank : 212)	θ value	0.0252991 (rank : 323)
Query Neighborhood Hits	467	Target Neighborhood Hits	201	Shared Neighborhood Hits	177
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

VINEX_MOUSE
NC score	0.478979 (rank : 213)	θ value	1.87187e-05 (rank : 142)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	193
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

RAI14_MOUSE
NC score	0.478822 (rank : 214)	θ value	2.44474e-05 (rank : 148)
Query Neighborhood Hits	467	Target Neighborhood Hits	1505	Shared Neighborhood Hits	279
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

SRC8_HUMAN
NC score	0.478445 (rank : 215)	θ value	4.0297e-08 (rank : 43)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	181
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ANKK1_HUMAN
NC score	0.478357 (rank : 216)	θ value	1.29631e-06 (rank : 88)
Query Neighborhood Hits	467	Target Neighborhood Hits	1075	Shared Neighborhood Hits	291
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANR40_HUMAN
NC score	0.477699 (rank : 217)	θ value	0.163984 (rank : 385)
Query Neighborhood Hits	467	Target Neighborhood Hits	224	Shared Neighborhood Hits	191
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

GRAP2_MOUSE
NC score	0.475950 (rank : 218)	θ value	1.06045e-08 (rank : 29)
Query Neighborhood Hits	467	Target Neighborhood Hits	297	Shared Neighborhood Hits	194
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

RIPK4_HUMAN
NC score	0.475744 (rank : 219)	θ value	1.53129e-07 (rank : 58)
Query Neighborhood Hits	467	Target Neighborhood Hits	1094	Shared Neighborhood Hits	294
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

NUD12_HUMAN
NC score	0.475361 (rank : 220)	θ value	0.00509761 (rank : 279)
Query Neighborhood Hits	467	Target Neighborhood Hits	222	Shared Neighborhood Hits	196
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

ANR43_MOUSE
NC score	0.475279 (rank : 221)	θ value	0.125558 (rank : 374)
Query Neighborhood Hits	467	Target Neighborhood Hits	214	Shared Neighborhood Hits	189
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

HCLS1_HUMAN
NC score	0.474392 (rank : 222)	θ value	7.59969e-07 (rank : 80)
Query Neighborhood Hits	467	Target Neighborhood Hits	358	Shared Neighborhood Hits	175
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ANR40_MOUSE
NC score	0.473851 (rank : 223)	θ value	0.47712 (rank : 401)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	194
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

GRAP2_HUMAN
NC score	0.472342 (rank : 224)	θ value	1.06045e-08 (rank : 28)
Query Neighborhood Hits	467	Target Neighborhood Hits	304	Shared Neighborhood Hits	196
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SRC8_MOUSE
NC score	0.472233 (rank : 225)	θ value	4.0297e-08 (rank : 44)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	180
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CDN2B_HUMAN
NC score	0.471988 (rank : 226)	θ value	0.0252991 (rank : 326)
Query Neighborhood Hits	467	Target Neighborhood Hits	196	Shared Neighborhood Hits	184
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

HCLS1_MOUSE
NC score	0.471239 (rank : 227)	θ value	2.61198e-07 (rank : 65)
Query Neighborhood Hits	467	Target Neighborhood Hits	329	Shared Neighborhood Hits	173
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SH3G3_MOUSE
NC score	0.470489 (rank : 228)	θ value	4.0297e-08 (rank : 42)
Query Neighborhood Hits	467	Target Neighborhood Hits	236	Shared Neighborhood Hits	186
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ANR43_HUMAN
NC score	0.469290 (rank : 229)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	467	Target Neighborhood Hits	209	Shared Neighborhood Hits	186
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

DDEF2_HUMAN
NC score	0.467604 (rank : 230)	θ value	0.000158464 (rank : 186)
Query Neighborhood Hits	467	Target Neighborhood Hits	599	Shared Neighborhood Hits	347
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.466940 (rank : 231)	θ value	0.000158464 (rank : 187)
Query Neighborhood Hits	467	Target Neighborhood Hits	625	Shared Neighborhood Hits	349
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP_MOUSE
NC score	0.466262 (rank : 232)	θ value	8.40245e-06 (rank : 129)
Query Neighborhood Hits	467	Target Neighborhood Hits	309	Shared Neighborhood Hits	211
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SH3G2_HUMAN
NC score	0.464702 (rank : 233)	θ value	4.0297e-08 (rank : 41)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	192
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ANKK1_MOUSE
NC score	0.464151 (rank : 234)	θ value	1.69304e-06 (rank : 95)
Query Neighborhood Hits	467	Target Neighborhood Hits	1072	Shared Neighborhood Hits	289
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

GRAP_HUMAN
NC score	0.463490 (rank : 235)	θ value	4.1701e-05 (rank : 154)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	208
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ABI2_MOUSE
NC score	0.462821 (rank : 236)	θ value	2.88788e-06 (rank : 104)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	189
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CD2A1_HUMAN
NC score	0.461363 (rank : 237)	θ value	5.27518 (rank : 451)
Query Neighborhood Hits	467	Target Neighborhood Hits	196	Shared Neighborhood Hits	180
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

SH3G3_HUMAN
NC score	0.460522 (rank : 238)	θ value	1.99992e-07 (rank : 63)
Query Neighborhood Hits	467	Target Neighborhood Hits	222	Shared Neighborhood Hits	180
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ABI2_HUMAN
NC score	0.460410 (rank : 239)	θ value	2.88788e-06 (rank : 103)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	192
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

AN30A_HUMAN
NC score	0.459861 (rank : 240)	θ value	0.125558 (rank : 372)
Query Neighborhood Hits	467	Target Neighborhood Hits	1119	Shared Neighborhood Hits	254
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

SRBS1_MOUSE
NC score	0.459002 (rank : 241)	θ value	0.000158464 (rank : 193)
Query Neighborhood Hits	467	Target Neighborhood Hits	409	Shared Neighborhood Hits	199
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.458612 (rank : 242)	θ value	9.29e-05 (rank : 172)
Query Neighborhood Hits	467	Target Neighborhood Hits	396	Shared Neighborhood Hits	201
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G2_MOUSE
NC score	0.458364 (rank : 243)	θ value	1.53129e-07 (rank : 59)
Query Neighborhood Hits	467	Target Neighborhood Hits	319	Shared Neighborhood Hits	186
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABTB2_HUMAN
NC score	0.458131 (rank : 244)	θ value	0.62314 (rank : 407)
Query Neighborhood Hits	467	Target Neighborhood Hits	391	Shared Neighborhood Hits	225
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

STAM1_HUMAN
NC score	0.456450 (rank : 245)	θ value	7.59969e-07 (rank : 81)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	200
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CLPB_HUMAN
NC score	0.456267 (rank : 246)	θ value	4.03905 (rank : 443)
Query Neighborhood Hits	467	Target Neighborhood Hits	265	Shared Neighborhood Hits	215
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

STAM1_MOUSE
NC score	0.455785 (rank : 247)	θ value	7.59969e-07 (rank : 82)
Query Neighborhood Hits	467	Target Neighborhood Hits	273	Shared Neighborhood Hits	200
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
NC score	0.454124 (rank : 248)	θ value	2.88788e-06 (rank : 111)
Query Neighborhood Hits	467	Target Neighborhood Hits	276	Shared Neighborhood Hits	188
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3G1_MOUSE
NC score	0.451952 (rank : 249)	θ value	1.99992e-07 (rank : 62)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	189
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STAM2_MOUSE
NC score	0.450561 (rank : 250)	θ value	7.59969e-07 (rank : 83)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	193
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABTB2_MOUSE
NC score	0.448794 (rank : 251)	θ value	0.47712 (rank : 400)
Query Neighborhood Hits	467	Target Neighborhood Hits	414	Shared Neighborhood Hits	225
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

NCK1_HUMAN
NC score	0.448185 (rank : 252)	θ value	0.000121331 (rank : 178)
Query Neighborhood Hits	467	Target Neighborhood Hits	312	Shared Neighborhood Hits	196
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3G1_HUMAN
NC score	0.447668 (rank : 253)	θ value	2.61198e-07 (rank : 68)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	185
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAC_MOUSE
NC score	0.446934 (rank : 254)	θ value	3.77169e-06 (rank : 115)
Query Neighborhood Hits	467	Target Neighborhood Hits	268	Shared Neighborhood Hits	187
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_MOUSE
NC score	0.442287 (rank : 255)	θ value	1.63604e-09 (rank : 18)
Query Neighborhood Hits	467	Target Neighborhood Hits	396	Shared Neighborhood Hits	206
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ABI1_MOUSE
NC score	0.441774 (rank : 256)	θ value	2.88788e-06 (rank : 102)
Query Neighborhood Hits	467	Target Neighborhood Hits	246	Shared Neighborhood Hits	176
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

STAM2_HUMAN
NC score	0.440726 (rank : 257)	θ value	5.81887e-07 (rank : 74)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	194
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

NCK2_HUMAN
NC score	0.439919 (rank : 258)	θ value	0.000461057 (rank : 220)
Query Neighborhood Hits	467	Target Neighborhood Hits	310	Shared Neighborhood Hits	186
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG7_HUMAN
NC score	0.436715 (rank : 259)	θ value	9.59137e-10 (rank : 14)
Query Neighborhood Hits	467	Target Neighborhood Hits	347	Shared Neighborhood Hits	203
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CENB5_HUMAN
NC score	0.432549 (rank : 260)	θ value	0.00228821 (rank : 251)
Query Neighborhood Hits	467	Target Neighborhood Hits	395	Shared Neighborhood Hits	235
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

ARHG6_MOUSE
NC score	0.428321 (rank : 261)	θ value	2.79066e-09 (rank : 20)
Query Neighborhood Hits	467	Target Neighborhood Hits	394	Shared Neighborhood Hits	197
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ABI1_HUMAN
NC score	0.427506 (rank : 262)	θ value	4.92598e-06 (rank : 118)
Query Neighborhood Hits	467	Target Neighborhood Hits	257	Shared Neighborhood Hits	174
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CENB2_HUMAN
NC score	0.423635 (rank : 263)	θ value	0.0252991 (rank : 327)
Query Neighborhood Hits	467	Target Neighborhood Hits	425	Shared Neighborhood Hits	230
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

ARHG6_HUMAN
NC score	0.423178 (rank : 264)	θ value	9.59137e-10 (rank : 13)
Query Neighborhood Hits	467	Target Neighborhood Hits	376	Shared Neighborhood Hits	192
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CENB1_HUMAN
NC score	0.418304 (rank : 265)	θ value	0.365318 (rank : 395)
Query Neighborhood Hits	467	Target Neighborhood Hits	383	Shared Neighborhood Hits	230
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CRKL_HUMAN
NC score	0.417146 (rank : 266)	θ value	0.00020696 (rank : 201)
Query Neighborhood Hits	467	Target Neighborhood Hits	313	Shared Neighborhood Hits	199
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NCF4_MOUSE
NC score	0.415562 (rank : 267)	θ value	0.00228821 (rank : 253)
Query Neighborhood Hits	467	Target Neighborhood Hits	177	Shared Neighborhood Hits	143
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GLSL_HUMAN
NC score	0.411870 (rank : 268)	θ value	4.03905 (rank : 444)
Query Neighborhood Hits	467	Target Neighborhood Hits	211	Shared Neighborhood Hits	193
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

CRKL_MOUSE
NC score	0.411326 (rank : 269)	θ value	0.000461057 (rank : 218)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	197
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DDEF1_MOUSE
NC score	0.404883 (rank : 270)	θ value	0.0113563 (rank : 304)
Query Neighborhood Hits	467	Target Neighborhood Hits	592	Shared Neighborhood Hits	301
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DNMBP_HUMAN
NC score	0.403575 (rank : 271)	θ value	2.88788e-06 (rank : 107)
Query Neighborhood Hits	467	Target Neighborhood Hits	413	Shared Neighborhood Hits	192
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAC3_HUMAN
NC score	0.403444 (rank : 272)	θ value	0.000158464 (rank : 194)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	154
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PPIP1_HUMAN
NC score	0.403137 (rank : 273)	θ value	0.000270298 (rank : 206)
Query Neighborhood Hits	467	Target Neighborhood Hits	389	Shared Neighborhood Hits	197
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GLSL_MOUSE
NC score	0.403072 (rank : 274)	θ value	5.27518 (rank : 453)
Query Neighborhood Hits	467	Target Neighborhood Hits	212	Shared Neighborhood Hits	194
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

TEX14_MOUSE
NC score	0.402392 (rank : 275)	θ value	9.92553e-07 (rank : 87)
Query Neighborhood Hits	467	Target Neighborhood Hits	1333	Shared Neighborhood Hits	273
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CRK_MOUSE
NC score	0.401681 (rank : 276)	θ value	0.00175202 (rank : 244)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	203
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC3_MOUSE
NC score	0.401621 (rank : 277)	θ value	0.000786445 (rank : 229)
Query Neighborhood Hits	467	Target Neighborhood Hits	232	Shared Neighborhood Hits	155
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CRK_HUMAN
NC score	0.400372 (rank : 278)	θ value	0.00175202 (rank : 243)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	205
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PPIP1_MOUSE
NC score	0.399830 (rank : 279)	θ value	0.00665767 (rank : 290)
Query Neighborhood Hits	467	Target Neighborhood Hits	377	Shared Neighborhood Hits	196
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ANKY1_HUMAN
NC score	0.399695 (rank : 280)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	467	Target Neighborhood Hits	248	Shared Neighborhood Hits	192
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

UACA_HUMAN
NC score	0.395099 (rank : 281)	θ value	0.000158464 (rank : 195)
Query Neighborhood Hits	467	Target Neighborhood Hits	1622	Shared Neighborhood Hits	271
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

NCF1_HUMAN
NC score	0.394954 (rank : 282)	θ value	0.00298849 (rank : 262)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	159
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF4_HUMAN
NC score	0.394944 (rank : 283)	θ value	0.00298849 (rank : 263)
Query Neighborhood Hits	467	Target Neighborhood Hits	161	Shared Neighborhood Hits	129
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

TEX14_HUMAN
NC score	0.394457 (rank : 284)	θ value	9.29e-05 (rank : 174)
Query Neighborhood Hits	467	Target Neighborhood Hits	1103	Shared Neighborhood Hits	256
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TNI3K_HUMAN
NC score	0.394126 (rank : 285)	θ value	4.92598e-06 (rank : 123)
Query Neighborhood Hits	467	Target Neighborhood Hits	1084	Shared Neighborhood Hits	295
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
NC score	0.392158 (rank : 286)	θ value	7.59969e-07 (rank : 84)
Query Neighborhood Hits	467	Target Neighborhood Hits	1079	Shared Neighborhood Hits	293
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

AN13B_MOUSE
NC score	0.389192 (rank : 287)	θ value	4.03905 (rank : 442)
Query Neighborhood Hits	467	Target Neighborhood Hits	276	Shared Neighborhood Hits	227
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

DNMBP_MOUSE
NC score	0.388949 (rank : 288)	θ value	0.000270298 (rank : 205)
Query Neighborhood Hits	467	Target Neighborhood Hits	435	Shared Neighborhood Hits	194
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

AN13B_HUMAN
NC score	0.388943 (rank : 289)	θ value	4.03905 (rank : 441)
Query Neighborhood Hits	467	Target Neighborhood Hits	265	Shared Neighborhood Hits	227
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

NCF1_MOUSE
NC score	0.387317 (rank : 290)	θ value	0.00665767 (rank : 289)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	161
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ASB14_HUMAN
NC score	0.386206 (rank : 291)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	467	Target Neighborhood Hits	187	Shared Neighborhood Hits	169
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

DDFL1_MOUSE
NC score	0.384924 (rank : 292)	θ value	0.00665767 (rank : 288)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	229
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

TRPV6_MOUSE
NC score	0.382840 (rank : 293)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	467	Target Neighborhood Hits	284	Shared Neighborhood Hits	223
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

PACN2_HUMAN
NC score	0.381198 (rank : 294)	θ value	0.00509761 (rank : 280)
Query Neighborhood Hits	467	Target Neighborhood Hits	339	Shared Neighborhood Hits	187
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABI3_HUMAN
NC score	0.379361 (rank : 295)	θ value	0.0252991 (rank : 322)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PACN2_MOUSE
NC score	0.378071 (rank : 296)	θ value	0.00175202 (rank : 247)
Query Neighborhood Hits	467	Target Neighborhood Hits	382	Shared Neighborhood Hits	190
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

UACA_MOUSE
NC score	0.376829 (rank : 297)	θ value	0.000158464 (rank : 196)
Query Neighborhood Hits	467	Target Neighborhood Hits	1620	Shared Neighborhood Hits	276
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

AN13C_HUMAN
NC score	0.373537 (rank : 298)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	467	Target Neighborhood Hits	241	Shared Neighborhood Hits	213
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

GLSK_HUMAN
NC score	0.372348 (rank : 299)	θ value	1.81305 (rank : 433)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	179
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

ABI3_MOUSE
NC score	0.371406 (rank : 300)	θ value	0.163984 (rank : 383)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANR26_MOUSE
NC score	0.368094 (rank : 301)	θ value	0.000270298 (rank : 204)
Query Neighborhood Hits	467	Target Neighborhood Hits	1554	Shared Neighborhood Hits	267
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

AN13C_MOUSE
NC score	0.366500 (rank : 302)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	467	Target Neighborhood Hits	242	Shared Neighborhood Hits	210
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

GIT2_MOUSE
NC score	0.365311 (rank : 303)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	467	Target Neighborhood Hits	323	Shared Neighborhood Hits	228
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

DBNL_HUMAN
NC score	0.364314 (rank : 304)	θ value	0.0252991 (rank : 328)
Query Neighborhood Hits	467	Target Neighborhood Hits	244	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PACN1_MOUSE
NC score	0.363606 (rank : 305)	θ value	0.0736092 (rank : 361)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	178
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

LASP1_HUMAN
NC score	0.362737 (rank : 306)	θ value	0.000158464 (rank : 188)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	156
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PACN1_HUMAN
NC score	0.362610 (rank : 307)	θ value	0.0736092 (rank : 360)
Query Neighborhood Hits	467	Target Neighborhood Hits	320	Shared Neighborhood Hits	179
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

DBNL_MOUSE
NC score	0.362210 (rank : 308)	θ value	0.0252991 (rank : 329)
Query Neighborhood Hits	467	Target Neighborhood Hits	306	Shared Neighborhood Hits	154
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

LASP1_MOUSE
NC score	0.361096 (rank : 309)	θ value	0.000158464 (rank : 189)
Query Neighborhood Hits	467	Target Neighborhood Hits	297	Shared Neighborhood Hits	154
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

VAV_MOUSE
NC score	0.358887 (rank : 310)	θ value	1.43324e-05 (rank : 139)
Query Neighborhood Hits	467	Target Neighborhood Hits	430	Shared Neighborhood Hits	186
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.357183 (rank : 311)	θ value	0.000158464 (rank : 197)
Query Neighborhood Hits	467	Target Neighborhood Hits	452	Shared Neighborhood Hits	182
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ANR26_HUMAN
NC score	0.354666 (rank : 312)	θ value	0.00035302 (rank : 210)
Query Neighborhood Hits	467	Target Neighborhood Hits	1614	Shared Neighborhood Hits	267
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

TRPV5_MOUSE
NC score	0.352668 (rank : 313)	θ value	1.06291 (rank : 422)
Query Neighborhood Hits	467	Target Neighborhood Hits	278	Shared Neighborhood Hits	215
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

GIT1_MOUSE
NC score	0.349028 (rank : 314)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	467	Target Neighborhood Hits	341	Shared Neighborhood Hits	226
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT1_HUMAN
NC score	0.348177 (rank : 315)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	467	Target Neighborhood Hits	336	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

NEBL_HUMAN
NC score	0.347425 (rank : 316)	θ value	5.44631e-05 (rank : 159)
Query Neighborhood Hits	467	Target Neighborhood Hits	457	Shared Neighborhood Hits	167
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NPHP1_MOUSE
NC score	0.345681 (rank : 317)	θ value	0.365318 (rank : 399)
Query Neighborhood Hits	467	Target Neighborhood Hits	267	Shared Neighborhood Hits	180
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

DAPK1_MOUSE
NC score	0.344668 (rank : 318)	θ value	6.00763e-12 (rank : 4)
Query Neighborhood Hits	467	Target Neighborhood Hits	1138	Shared Neighborhood Hits	296
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

NOTC4_MOUSE
NC score	0.342710 (rank : 319)	θ value	0.00020696 (rank : 202)
Query Neighborhood Hits	467	Target Neighborhood Hits	872	Shared Neighborhood Hits	253
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

PACN3_MOUSE
NC score	0.342304 (rank : 320)	θ value	0.0330416 (rank : 340)
Query Neighborhood Hits	467	Target Neighborhood Hits	380	Shared Neighborhood Hits	173
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.340112 (rank : 321)	θ value	0.0563607 (rank : 353)
Query Neighborhood Hits	467	Target Neighborhood Hits	385	Shared Neighborhood Hits	170
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ITSN2_HUMAN
NC score	0.338620 (rank : 322)	θ value	1.29631e-06 (rank : 92)
Query Neighborhood Hits	467	Target Neighborhood Hits	1173	Shared Neighborhood Hits	222
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NOTC4_HUMAN
NC score	0.337868 (rank : 323)	θ value	0.000158464 (rank : 190)
Query Neighborhood Hits	467	Target Neighborhood Hits	905	Shared Neighborhood Hits	252
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

VAV2_HUMAN
NC score	0.337472 (rank : 324)	θ value	0.000121331 (rank : 180)
Query Neighborhood Hits	467	Target Neighborhood Hits	453	Shared Neighborhood Hits	173
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

DAPK1_HUMAN
NC score	0.337207 (rank : 325)	θ value	3.64472e-09 (rank : 21)
Query Neighborhood Hits	467	Target Neighborhood Hits	1130	Shared Neighborhood Hits	293
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

VAV2_MOUSE
NC score	0.337025 (rank : 326)	θ value	0.000121331 (rank : 181)
Query Neighborhood Hits	467	Target Neighborhood Hits	456	Shared Neighborhood Hits	174
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CT032_HUMAN
NC score	0.336111 (rank : 327)	θ value	0.00390308 (rank : 270)
Query Neighborhood Hits	467	Target Neighborhood Hits	235	Shared Neighborhood Hits	140
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

GIT2_HUMAN
NC score	0.335023 (rank : 328)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	467	Target Neighborhood Hits	381	Shared Neighborhood Hits	221
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

AN13A_HUMAN
NC score	0.330355 (rank : 329)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	467	Target Neighborhood Hits	243	Shared Neighborhood Hits	201
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

CT012_MOUSE
NC score	0.330334 (rank : 330)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	467	Target Neighborhood Hits	229	Shared Neighborhood Hits	162
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

VAV3_HUMAN
NC score	0.328703 (rank : 331)	θ value	0.00035302 (rank : 216)
Query Neighborhood Hits	467	Target Neighborhood Hits	398	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN2_MOUSE
NC score	0.327806 (rank : 332)	θ value	1.29631e-06 (rank : 93)
Query Neighborhood Hits	467	Target Neighborhood Hits	1371	Shared Neighborhood Hits	228
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DGKZ_HUMAN
NC score	0.326272 (rank : 333)	θ value	0.00175202 (rank : 245)
Query Neighborhood Hits	467	Target Neighborhood Hits	551	Shared Neighborhood Hits	206
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

ITSN1_MOUSE
NC score	0.323898 (rank : 334)	θ value	4.0297e-08 (rank : 40)
Query Neighborhood Hits	467	Target Neighborhood Hits	1669	Shared Neighborhood Hits	241
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TRPV5_HUMAN
NC score	0.323537 (rank : 335)	θ value	1.06291 (rank : 421)
Query Neighborhood Hits	467	Target Neighborhood Hits	261	Shared Neighborhood Hits	199
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

VAV3_MOUSE
NC score	0.323316 (rank : 336)	θ value	0.000602161 (rank : 226)
Query Neighborhood Hits	467	Target Neighborhood Hits	404	Shared Neighborhood Hits	175
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CT012_HUMAN
NC score	0.323082 (rank : 337)	θ value	1.38821 (rank : 426)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

ITSN1_HUMAN
NC score	0.320509 (rank : 338)	θ value	1.17247e-07 (rank : 56)
Query Neighborhood Hits	467	Target Neighborhood Hits	1757	Shared Neighborhood Hits	238
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

AHI1_HUMAN
NC score	0.318185 (rank : 339)	θ value	0.00175202 (rank : 240)
Query Neighborhood Hits	467	Target Neighborhood Hits	537	Shared Neighborhood Hits	190
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

TRPV6_HUMAN
NC score	0.314695 (rank : 340)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	467	Target Neighborhood Hits	262	Shared Neighborhood Hits	200
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

AHI1_MOUSE
NC score	0.314661 (rank : 341)	θ value	0.00020696 (rank : 198)
Query Neighborhood Hits	467	Target Neighborhood Hits	496	Shared Neighborhood Hits	190
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AN13A_MOUSE
NC score	0.312140 (rank : 342)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	467	Target Neighborhood Hits	226	Shared Neighborhood Hits	197
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

PLCG1_MOUSE
NC score	0.307700 (rank : 343)	θ value	0.00390308 (rank : 273)
Query Neighborhood Hits	467	Target Neighborhood Hits	314	Shared Neighborhood Hits	159
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NPHP1_HUMAN
NC score	0.307450 (rank : 344)	θ value	0.62314 (rank : 413)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	159
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

DDFL1_HUMAN
NC score	0.307337 (rank : 345)	θ value	0.365318 (rank : 396)
Query Neighborhood Hits	467	Target Neighborhood Hits	353	Shared Neighborhood Hits	212
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

NEBU_HUMAN
NC score	0.306305 (rank : 346)	θ value	7.1131e-05 (rank : 167)
Query Neighborhood Hits	467	Target Neighborhood Hits	420	Shared Neighborhood Hits	164
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

DGKZ_MOUSE
NC score	0.306181 (rank : 347)	θ value	0.00390308 (rank : 271)
Query Neighborhood Hits	467	Target Neighborhood Hits	542	Shared Neighborhood Hits	192
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

BCAR1_MOUSE
NC score	0.304737 (rank : 348)	θ value	0.0113563 (rank : 303)
Query Neighborhood Hits	467	Target Neighborhood Hits	438	Shared Neighborhood Hits	170
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NOTC3_MOUSE
NC score	0.301826 (rank : 349)	θ value	0.0431538 (rank : 349)
Query Neighborhood Hits	467	Target Neighborhood Hits	975	Shared Neighborhood Hits	251
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PLCG2_HUMAN
NC score	0.299659 (rank : 350)	θ value	0.0330416 (rank : 341)
Query Neighborhood Hits	467	Target Neighborhood Hits	280	Shared Neighborhood Hits	153
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NOTC1_HUMAN
NC score	0.299474 (rank : 351)	θ value	0.0330416 (rank : 338)
Query Neighborhood Hits	467	Target Neighborhood Hits	906	Shared Neighborhood Hits	249
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC3_HUMAN
NC score	0.299119 (rank : 352)	θ value	0.0431538 (rank : 348)
Query Neighborhood Hits	467	Target Neighborhood Hits	1062	Shared Neighborhood Hits	248
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

BCAR1_HUMAN
NC score	0.298388 (rank : 353)	θ value	0.00869519 (rank : 294)
Query Neighborhood Hits	467	Target Neighborhood Hits	554	Shared Neighborhood Hits	173
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ABTB1_MOUSE
NC score	0.296372 (rank : 354)	θ value	0.000602161 (rank : 223)
Query Neighborhood Hits	467	Target Neighborhood Hits	349	Shared Neighborhood Hits	172
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

NOTC2_HUMAN
NC score	0.295745 (rank : 355)	θ value	1.38821 (rank : 430)
Query Neighborhood Hits	467	Target Neighborhood Hits	1113	Shared Neighborhood Hits	251
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PLCG1_HUMAN
NC score	0.295029 (rank : 356)	θ value	0.0113563 (rank : 308)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	152
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NOTC2_MOUSE
NC score	0.293375 (rank : 357)	θ value	1.81305 (rank : 435)
Query Neighborhood Hits	467	Target Neighborhood Hits	1069	Shared Neighborhood Hits	251
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

ARHG4_HUMAN
NC score	0.291163 (rank : 358)	θ value	0.0330416 (rank : 334)
Query Neighborhood Hits	467	Target Neighborhood Hits	242	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CASL_MOUSE
NC score	0.286003 (rank : 359)	θ value	0.00665767 (rank : 287)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	146
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.283703 (rank : 360)	θ value	0.00509761 (rank : 278)
Query Neighborhood Hits	467	Target Neighborhood Hits	259	Shared Neighborhood Hits	149
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DGKI_HUMAN
NC score	0.280892 (rank : 361)	θ value	0.21417 (rank : 391)
Query Neighborhood Hits	467	Target Neighborhood Hits	609	Shared Neighborhood Hits	198
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

EFS_MOUSE
NC score	0.276854 (rank : 362)	θ value	0.62314 (rank : 410)
Query Neighborhood Hits	467	Target Neighborhood Hits	389	Shared Neighborhood Hits	156
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ARHG9_HUMAN
NC score	0.274469 (rank : 363)	θ value	0.125558 (rank : 375)
Query Neighborhood Hits	467	Target Neighborhood Hits	235	Shared Neighborhood Hits	155
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.274189 (rank : 364)	θ value	0.125558 (rank : 376)
Query Neighborhood Hits	467	Target Neighborhood Hits	234	Shared Neighborhood Hits	155
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

EFS_HUMAN
NC score	0.266482 (rank : 365)	θ value	0.62314 (rank : 409)
Query Neighborhood Hits	467	Target Neighborhood Hits	348	Shared Neighborhood Hits	153
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

RIMB2_HUMAN
NC score	0.264728 (rank : 366)	θ value	0.0330416 (rank : 343)
Query Neighborhood Hits	467	Target Neighborhood Hits	263	Shared Neighborhood Hits	122
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

NOXO1_MOUSE
NC score	0.263909 (rank : 367)	θ value	0.0330416 (rank : 339)
Query Neighborhood Hits	467	Target Neighborhood Hits	114	Shared Neighborhood Hits	101
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ABTB1_HUMAN
NC score	0.261362 (rank : 368)	θ value	0.00134147 (rank : 236)
Query Neighborhood Hits	467	Target Neighborhood Hits	325	Shared Neighborhood Hits	157
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

RIMB2_MOUSE
NC score	0.258229 (rank : 369)	θ value	0.0330416 (rank : 344)
Query Neighborhood Hits	467	Target Neighborhood Hits	246	Shared Neighborhood Hits	114
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RHG04_HUMAN
NC score	0.257415 (rank : 370)	θ value	0.000158464 (rank : 192)
Query Neighborhood Hits	467	Target Neighborhood Hits	307	Shared Neighborhood Hits	169
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NOTC1_MOUSE
NC score	0.252588 (rank : 371)	θ value	0.0252991 (rank : 332)
Query Neighborhood Hits	467	Target Neighborhood Hits	916	Shared Neighborhood Hits	239
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ES8L3_MOUSE
NC score	0.248612 (rank : 372)	θ value	0.00390308 (rank : 272)
Query Neighborhood Hits	467	Target Neighborhood Hits	168	Shared Neighborhood Hits	136
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

IKBL_MOUSE
NC score	0.247790 (rank : 373)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	467	Target Neighborhood Hits	196	Shared Neighborhood Hits	132
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

CENG2_HUMAN
NC score	0.247497 (rank : 374)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	467	Target Neighborhood Hits	471	Shared Neighborhood Hits	225
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

IKBL_HUMAN
NC score	0.246585 (rank : 375)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	467	Target Neighborhood Hits	168	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

CENG2_MOUSE
NC score	0.246380 (rank : 376)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	467	Target Neighborhood Hits	463	Shared Neighborhood Hits	224
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG1_MOUSE
NC score	0.246216 (rank : 377)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	467	Target Neighborhood Hits	531	Shared Neighborhood Hits	216
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

SNX18_MOUSE
NC score	0.244989 (rank : 378)	θ value	0.813845 (rank : 416)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CENG1_HUMAN
NC score	0.243777 (rank : 379)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	467	Target Neighborhood Hits	544	Shared Neighborhood Hits	216
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

ANKZ1_MOUSE
NC score	0.243733 (rank : 380)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	467	Target Neighborhood Hits	208	Shared Neighborhood Hits	140
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

PEX13_HUMAN
NC score	0.243188 (rank : 381)	θ value	6.88961 (rank : 459)
Query Neighborhood Hits	467	Target Neighborhood Hits	128	Shared Neighborhood Hits	113
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SNX18_HUMAN
NC score	0.239910 (rank : 382)	θ value	1.06291 (rank : 420)
Query Neighborhood Hits	467	Target Neighborhood Hits	207	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PEX13_MOUSE
NC score	0.239386 (rank : 383)	θ value	8.99809 (rank : 465)
Query Neighborhood Hits	467	Target Neighborhood Hits	126	Shared Neighborhood Hits	117
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ANM2_HUMAN
NC score	0.238511 (rank : 384)	θ value	0.163984 (rank : 384)
Query Neighborhood Hits	467	Target Neighborhood Hits	175	Shared Neighborhood Hits	147
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SPN90_HUMAN
NC score	0.237119 (rank : 385)	θ value	0.0252991 (rank : 333)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ARHG4_MOUSE
NC score	0.234512 (rank : 386)	θ value	0.279714 (rank : 393)
Query Neighborhood Hits	467	Target Neighborhood Hits	185	Shared Neighborhood Hits	117
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ES8L3_HUMAN
NC score	0.233574 (rank : 387)	θ value	0.00298849 (rank : 261)
Query Neighborhood Hits	467	Target Neighborhood Hits	206	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RUSC1_HUMAN
NC score	0.232263 (rank : 388)	θ value	0.62314 (rank : 414)
Query Neighborhood Hits	467	Target Neighborhood Hits	226	Shared Neighborhood Hits	134
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SRGP2_MOUSE
NC score	0.230259 (rank : 389)	θ value	0.0113563 (rank : 312)
Query Neighborhood Hits	467	Target Neighborhood Hits	324	Shared Neighborhood Hits	153
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ANM2_MOUSE
NC score	0.228613 (rank : 390)	θ value	0.0961366 (rank : 363)
Query Neighborhood Hits	467	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP2_HUMAN
NC score	0.227512 (rank : 391)	θ value	0.0113563 (rank : 311)
Query Neighborhood Hits	467	Target Neighborhood Hits	331	Shared Neighborhood Hits	149
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ANKZ1_HUMAN
NC score	0.226331 (rank : 392)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	467	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

FNBP2_HUMAN
NC score	0.217213 (rank : 393)	θ value	0.0113563 (rank : 305)
Query Neighborhood Hits	467	Target Neighborhood Hits	432	Shared Neighborhood Hits	149
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SPN90_MOUSE
NC score	0.216633 (rank : 394)	θ value	0.0113563 (rank : 309)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

CLR59_HUMAN
NC score	0.216567 (rank : 395)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	467	Target Neighborhood Hits	163	Shared Neighborhood Hits	134
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

SRGP1_HUMAN
NC score	0.215085 (rank : 396)	θ value	0.125558 (rank : 381)
Query Neighborhood Hits	467	Target Neighborhood Hits	390	Shared Neighborhood Hits	149
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RUSC1_MOUSE
NC score	0.213367 (rank : 397)	θ value	0.47712 (rank : 406)
Query Neighborhood Hits	467	Target Neighborhood Hits	206	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RHG26_HUMAN
NC score	0.212709 (rank : 398)	θ value	0.0193708 (rank : 320)
Query Neighborhood Hits	467	Target Neighborhood Hits	281	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CENG3_MOUSE
NC score	0.212022 (rank : 399)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	467	Target Neighborhood Hits	467	Shared Neighborhood Hits	206
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.211046 (rank : 400)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	203
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

BAT4_MOUSE
NC score	0.206750 (rank : 401)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	467	Target Neighborhood Hits	171	Shared Neighborhood Hits	114
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

SLAP2_MOUSE
NC score	0.204726 (rank : 402)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	467	Target Neighborhood Hits	136	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPTA2_HUMAN
NC score	0.204595 (rank : 403)	θ value	1.29631e-06 (rank : 94)
Query Neighborhood Hits	467	Target Neighborhood Hits	888	Shared Neighborhood Hits	185
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SLAP2_HUMAN
NC score	0.204258 (rank : 404)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	467	Target Neighborhood Hits	139	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

MYO1F_HUMAN
NC score	0.199046 (rank : 405)	θ value	2.44474e-05 (rank : 147)
Query Neighborhood Hits	467	Target Neighborhood Hits	275	Shared Neighborhood Hits	190
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.197386 (rank : 406)	θ value	1.09739e-05 (rank : 135)
Query Neighborhood Hits	467	Target Neighborhood Hits	262	Shared Neighborhood Hits	189
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ANKR9_MOUSE
NC score	0.197207 (rank : 407)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	467	Target Neighborhood Hits	120	Shared Neighborhood Hits	103
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

FYN_MOUSE
NC score	0.194495 (rank : 408)	θ value	2.88788e-06 (rank : 109)
Query Neighborhood Hits	467	Target Neighborhood Hits	1073	Shared Neighborhood Hits	208
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FGR_HUMAN
NC score	0.194479 (rank : 409)	θ value	7.59969e-07 (rank : 79)
Query Neighborhood Hits	467	Target Neighborhood Hits	1067	Shared Neighborhood Hits	203
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SHAN2_MOUSE
NC score	0.194033 (rank : 410)	θ value	0.0961366 (rank : 371)
Query Neighborhood Hits	467	Target Neighborhood Hits	446	Shared Neighborhood Hits	123
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

MYO1E_HUMAN
NC score	0.193627 (rank : 411)	θ value	4.92598e-06 (rank : 121)
Query Neighborhood Hits	467	Target Neighborhood Hits	293	Shared Neighborhood Hits	184
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SLAP1_HUMAN
NC score	0.193569 (rank : 412)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	467	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

STS2_HUMAN
NC score	0.191771 (rank : 413)	θ value	0.125558 (rank : 382)
Query Neighborhood Hits	467	Target Neighborhood Hits	108	Shared Neighborhood Hits	82
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

FYN_HUMAN
NC score	0.191369 (rank : 414)	θ value	2.88788e-06 (rank : 108)
Query Neighborhood Hits	467	Target Neighborhood Hits	1078	Shared Neighborhood Hits	208
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.191167 (rank : 415)	θ value	3.77169e-06 (rank : 116)
Query Neighborhood Hits	467	Target Neighborhood Hits	1052	Shared Neighborhood Hits	203
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SLAP1_MOUSE
NC score	0.190365 (rank : 416)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	467	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

YES_HUMAN
NC score	0.190200 (rank : 417)	θ value	1.69304e-06 (rank : 98)
Query Neighborhood Hits	467	Target Neighborhood Hits	1059	Shared Neighborhood Hits	202
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.189399 (rank : 418)	θ value	6.43352e-06 (rank : 126)
Query Neighborhood Hits	467	Target Neighborhood Hits	1069	Shared Neighborhood Hits	201
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SPTA1_HUMAN
NC score	0.188967 (rank : 419)	θ value	0.000121331 (rank : 179)
Query Neighborhood Hits	467	Target Neighborhood Hits	748	Shared Neighborhood Hits	169
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NOXO1_HUMAN
NC score	0.188657 (rank : 420)	θ value	5.27518 (rank : 455)
Query Neighborhood Hits	467	Target Neighborhood Hits	100	Shared Neighborhood Hits	89
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BAT4_HUMAN
NC score	0.188633 (rank : 421)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	104
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

SPTA1_MOUSE
NC score	0.188301 (rank : 422)	θ value	0.0113563 (rank : 310)
Query Neighborhood Hits	467	Target Neighborhood Hits	675	Shared Neighborhood Hits	159
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRC_HUMAN
NC score	0.186869 (rank : 423)	θ value	4.92598e-06 (rank : 122)
Query Neighborhood Hits	467	Target Neighborhood Hits	1058	Shared Neighborhood Hits	206
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TCGAP_MOUSE
NC score	0.178976 (rank : 424)	θ value	0.00175202 (rank : 249)
Query Neighborhood Hits	467	Target Neighborhood Hits	409	Shared Neighborhood Hits	125
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STS1_MOUSE
NC score	0.178771 (rank : 425)	θ value	0.00509761 (rank : 282)
Query Neighborhood Hits	467	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_HUMAN
NC score	0.177338 (rank : 426)	θ value	0.00665767 (rank : 291)
Query Neighborhood Hits	467	Target Neighborhood Hits	106	Shared Neighborhood Hits	74
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BTK_HUMAN
NC score	0.173451 (rank : 427)	θ value	3.77169e-06 (rank : 113)
Query Neighborhood Hits	467	Target Neighborhood Hits	1026	Shared Neighborhood Hits	191
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

M3KL4_HUMAN
NC score	0.173119 (rank : 428)	θ value	0.000602161 (rank : 225)
Query Neighborhood Hits	467	Target Neighborhood Hits	1087	Shared Neighborhood Hits	190
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RSNL2_HUMAN
NC score	0.172626 (rank : 429)	θ value	8.99809 (rank : 466)
Query Neighborhood Hits	467	Target Neighborhood Hits	136	Shared Neighborhood Hits	109
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

RIMB1_HUMAN
NC score	0.172341 (rank : 430)	θ value	0.00228821 (rank : 256)
Query Neighborhood Hits	467	Target Neighborhood Hits	1479	Shared Neighborhood Hits	160
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SHLB1_MOUSE
NC score	0.171676 (rank : 431)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	467	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

BTK_MOUSE
NC score	0.169603 (rank : 432)	θ value	1.29631e-06 (rank : 90)
Query Neighborhood Hits	467	Target Neighborhood Hits	1017	Shared Neighborhood Hits	183
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ES8L2_HUMAN
NC score	0.169394 (rank : 433)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	467	Target Neighborhood Hits	193	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SRC_MOUSE
NC score	0.169175 (rank : 434)	θ value	9.29e-05 (rank : 173)
Query Neighborhood Hits	467	Target Neighborhood Hits	1033	Shared Neighborhood Hits	176
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SHLB1_HUMAN
NC score	0.168835 (rank : 435)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	467	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

HCK_MOUSE
NC score	0.167650 (rank : 436)	θ value	0.0193708 (rank : 319)
Query Neighborhood Hits	467	Target Neighborhood Hits	1029	Shared Neighborhood Hits	181
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ES8L2_MOUSE
NC score	0.166883 (rank : 437)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	467	Target Neighborhood Hits	169	Shared Neighborhood Hits	120
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

HCK_HUMAN
NC score	0.166011 (rank : 438)	θ value	0.0736092 (rank : 359)
Query Neighborhood Hits	467	Target Neighborhood Hits	1035	Shared Neighborhood Hits	183
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ARHG5_HUMAN
NC score	0.165487 (rank : 439)	θ value	0.0252991 (rank : 324)
Query Neighborhood Hits	467	Target Neighborhood Hits	172	Shared Neighborhood Hits	91
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

M3K11_HUMAN
NC score	0.164310 (rank : 440)	θ value	0.000461057 (rank : 219)
Query Neighborhood Hits	467	Target Neighborhood Hits	1136	Shared Neighborhood Hits	192
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TCGAP_HUMAN
NC score	0.164024 (rank : 441)	θ value	0.00175202 (rank : 248)
Query Neighborhood Hits	467	Target Neighborhood Hits	872	Shared Neighborhood Hits	134
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RIMB1_MOUSE
NC score	0.164000 (rank : 442)	θ value	0.00134147 (rank : 239)
Query Neighborhood Hits	467	Target Neighborhood Hits	1376	Shared Neighborhood Hits	177
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

FRK_HUMAN
NC score	0.161791 (rank : 443)	θ value	0.00102713 (rank : 232)
Query Neighborhood Hits	467	Target Neighborhood Hits	1058	Shared Neighborhood Hits	200
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ANKR9_HUMAN
NC score	0.161515 (rank : 444)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	467	Target Neighborhood Hits	99	Shared Neighborhood Hits	84
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

EPS8_HUMAN
NC score	0.158737 (rank : 445)	θ value	1.81305 (rank : 432)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	104
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
NC score	0.158725 (rank : 446)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	467	Target Neighborhood Hits	162	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

EPS8_MOUSE
NC score	0.158130 (rank : 447)	θ value	5.27518 (rank : 452)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	119
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

M3K9_HUMAN
NC score	0.157898 (rank : 448)	θ value	0.00869519 (rank : 297)
Query Neighborhood Hits	467	Target Neighborhood Hits	1123	Shared Neighborhood Hits	188
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

LYN_HUMAN
NC score	0.157867 (rank : 449)	θ value	0.0330416 (rank : 335)
Query Neighborhood Hits	467	Target Neighborhood Hits	1022	Shared Neighborhood Hits	167
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.157675 (rank : 450)	θ value	0.0113563 (rank : 307)
Query Neighborhood Hits	467	Target Neighborhood Hits	1023	Shared Neighborhood Hits	168
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CMTA1_HUMAN
NC score	0.156140 (rank : 451)	θ value	6.88961 (rank : 456)
Query Neighborhood Hits	467	Target Neighborhood Hits	217	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

SHLB2_MOUSE
NC score	0.155299 (rank : 452)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	467	Target Neighborhood Hits	88	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SNX9_HUMAN
NC score	0.155162 (rank : 453)	θ value	3.0926 (rank : 440)
Query Neighborhood Hits	467	Target Neighborhood Hits	148	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

EM55_HUMAN
NC score	0.154205 (rank : 454)	θ value	0.0563607 (rank : 351)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	105
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SHLB2_HUMAN
NC score	0.153589 (rank : 455)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	467	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ES8L1_MOUSE
NC score	0.153587 (rank : 456)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	467	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

TXK_MOUSE
NC score	0.153419 (rank : 457)	θ value	9.29e-05 (rank : 175)
Query Neighborhood Hits	467	Target Neighborhood Hits	980	Shared Neighborhood Hits	160
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FUT8_HUMAN
NC score	0.153217 (rank : 458)	θ value	5.44631e-05 (rank : 158)
Query Neighborhood Hits	467	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

BLK_HUMAN
NC score	0.151406 (rank : 459)	θ value	5.27518 (rank : 450)
Query Neighborhood Hits	467	Target Neighborhood Hits	994	Shared Neighborhood Hits	154
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EM55_MOUSE
NC score	0.149960 (rank : 460)	θ value	0.0961366 (rank : 366)
Query Neighborhood Hits	467	Target Neighborhood Hits	221	Shared Neighborhood Hits	101
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

TRPV3_HUMAN
NC score	0.149686 (rank : 461)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	467	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV3_MOUSE
NC score	0.149371 (rank : 462)	θ value	6.88961 (rank : 463)
Query Neighborhood Hits	467	Target Neighborhood Hits	188	Shared Neighborhood Hits	118
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

M3K10_HUMAN
NC score	0.148754 (rank : 463)	θ value	0.0330416 (rank : 336)
Query Neighborhood Hits	467	Target Neighborhood Hits	1071	Shared Neighborhood Hits	176
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

TRPV1_MOUSE
NC score	0.148639 (rank : 464)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	467	Target Neighborhood Hits	189	Shared Neighborhood Hits	134
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

LCK_HUMAN
NC score	0.148440 (rank : 465)	θ value	0.00175202 (rank : 246)
Query Neighborhood Hits	467	Target Neighborhood Hits	987	Shared Neighborhood Hits	136
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BLK_MOUSE
NC score	0.147961 (rank : 466)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	467	Target Neighborhood Hits	992	Shared Neighborhood Hits	145
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

TEC_HUMAN
NC score	0.147490 (rank : 467)	θ value	0.0148317 (rank : 316)
Query Neighborhood Hits	467	Target Neighborhood Hits	1006	Shared Neighborhood Hits	154
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LCK_MOUSE
NC score	0.147382 (rank : 468)	θ value	0.00228821 (rank : 252)
Query Neighborhood Hits	467	Target Neighborhood Hits	981	Shared Neighborhood Hits	134
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

RSNL2_MOUSE
NC score	0.147378 (rank : 469)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	467	Target Neighborhood Hits	129	Shared Neighborhood Hits	92
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

PTK6_MOUSE
NC score	0.146571 (rank : 470)	θ value	0.00228821 (rank : 255)
Query Neighborhood Hits	467	Target Neighborhood Hits	1026	Shared Neighborhood Hits	175
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

P85A_MOUSE
NC score	0.145882 (rank : 471)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	467	Target Neighborhood Hits	435	Shared Neighborhood Hits	115
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TXK_HUMAN
NC score	0.145205 (rank : 472)	θ value	0.00102713 (rank : 235)
Query Neighborhood Hits	467	Target Neighborhood Hits	971	Shared Neighborhood Hits	143
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CSK_HUMAN
NC score	0.144750 (rank : 473)	θ value	0.0431538 (rank : 346)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	153
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.144499 (rank : 474)	θ value	0.0431538 (rank : 347)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	153
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

TEC_MOUSE
NC score	0.144091 (rank : 475)	θ value	0.0193708 (rank : 321)
Query Neighborhood Hits	467	Target Neighborhood Hits	1006	Shared Neighborhood Hits	154
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.142928 (rank : 476)	θ value	0.0330416 (rank : 342)
Query Neighborhood Hits	467	Target Neighborhood Hits	1020	Shared Neighborhood Hits	178
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

MPP6_HUMAN
NC score	0.142921 (rank : 477)	θ value	0.365318 (rank : 397)
Query Neighborhood Hits	467	Target Neighborhood Hits	180	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

RASA1_HUMAN
NC score	0.142390 (rank : 478)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	467	Target Neighborhood Hits	258	Shared Neighborhood Hits	68
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

FUT8_MOUSE
NC score	0.141525 (rank : 479)	θ value	0.00102713 (rank : 233)
Query Neighborhood Hits	467	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SNX9_MOUSE
NC score	0.140518 (rank : 480)	θ value	6.88961 (rank : 462)
Query Neighborhood Hits	467	Target Neighborhood Hits	141	Shared Neighborhood Hits	88
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

CMTA2_HUMAN
NC score	0.140357 (rank : 481)	θ value	1.38821 (rank : 424)
Query Neighborhood Hits	467	Target Neighborhood Hits	199	Shared Neighborhood Hits	87
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

ITK_HUMAN
NC score	0.140091 (rank : 482)	θ value	0.0252991 (rank : 330)
Query Neighborhood Hits	467	Target Neighborhood Hits	1016	Shared Neighborhood Hits	146
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MPP6_MOUSE
NC score	0.139385 (rank : 483)	θ value	0.365318 (rank : 398)
Query Neighborhood Hits	467	Target Neighborhood Hits	187	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

P85A_HUMAN
NC score	0.138209 (rank : 484)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	467	Target Neighborhood Hits	479	Shared Neighborhood Hits	112
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TRPV1_HUMAN
NC score	0.136134 (rank : 485)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	467	Target Neighborhood Hits	184	Shared Neighborhood Hits	128
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

SLY_MOUSE
NC score	0.134682 (rank : 486)	θ value	1.81305 (rank : 436)
Query Neighborhood Hits	467	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

ITK_MOUSE
NC score	0.134560 (rank : 487)	θ value	0.0252991 (rank : 331)
Query Neighborhood Hits	467	Target Neighborhood Hits	985	Shared Neighborhood Hits	133
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ABL1_HUMAN
NC score	0.134036 (rank : 488)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	467	Target Neighborhood Hits	1220	Shared Neighborhood Hits	149
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.132786 (rank : 489)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	467	Target Neighborhood Hits	1178	Shared Neighborhood Hits	144
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.131814 (rank : 490)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	467	Target Neighborhood Hits	1045	Shared Neighborhood Hits	135
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CMTA2_MOUSE
NC score	0.128591 (rank : 491)	θ value	1.38821 (rank : 425)
Query Neighborhood Hits	467	Target Neighborhood Hits	216	Shared Neighborhood Hits	73
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

DAPP1_HUMAN
NC score	0.127736 (rank : 492)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.127549 (rank : 493)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CIP4_HUMAN
NC score	0.127305 (rank : 494)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	467	Target Neighborhood Hits	374	Shared Neighborhood Hits	79
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SH21B_MOUSE
NC score	0.127056 (rank : 495)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	467	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

NGEF_MOUSE
NC score	0.126090 (rank : 496)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

P85B_HUMAN
NC score	0.125819 (rank : 497)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	467	Target Neighborhood Hits	543	Shared Neighborhood Hits	89
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DOCK1_HUMAN
NC score	0.125652 (rank : 498)	θ value	0.163984 (rank : 387)
Query Neighborhood Hits	467	Target Neighborhood Hits	191	Shared Neighborhood Hits	115
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

P85B_MOUSE
NC score	0.125011 (rank : 499)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	467	Target Neighborhood Hits	519	Shared Neighborhood Hits	90
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

NGEF_HUMAN
NC score	0.124826 (rank : 500)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	467	Target Neighborhood Hits	166	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SRMS_MOUSE
NC score	0.123026 (rank : 501)	θ value	0.813845 (rank : 417)
Query Neighborhood Hits	467	Target Neighborhood Hits	964	Shared Neighborhood Hits	117
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TRPV2_HUMAN
NC score	0.122520 (rank : 502)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	467	Target Neighborhood Hits	130	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

SH21B_HUMAN
NC score	0.121465 (rank : 503)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	467	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

MPP2_HUMAN
NC score	0.120408 (rank : 504)	θ value	0.62314 (rank : 411)
Query Neighborhood Hits	467	Target Neighborhood Hits	173	Shared Neighborhood Hits	82
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
NC score	0.120052 (rank : 505)	θ value	0.62314 (rank : 412)
Query Neighborhood Hits	467	Target Neighborhood Hits	189	Shared Neighborhood Hits	81
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

JIP1_HUMAN
NC score	0.119366 (rank : 506)	θ value	0.125558 (rank : 377)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MPP5_HUMAN
NC score	0.119328 (rank : 507)	θ value	0.125558 (rank : 378)
Query Neighborhood Hits	467	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

LRRK1_MOUSE
NC score	0.118693 (rank : 508)	θ value	1.38821 (rank : 429)
Query Neighborhood Hits	467	Target Neighborhood Hits	1267	Shared Neighborhood Hits	154
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MPP5_MOUSE
NC score	0.118652 (rank : 509)	θ value	0.125558 (rank : 379)
Query Neighborhood Hits	467	Target Neighborhood Hits	226	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

JIP1_MOUSE
NC score	0.118277 (rank : 510)	θ value	0.0961366 (rank : 368)
Query Neighborhood Hits	467	Target Neighborhood Hits	259	Shared Neighborhood Hits	63
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
NC score	0.117899 (rank : 511)	θ value	0.47712 (rank : 403)
Query Neighborhood Hits	467	Target Neighborhood Hits	288	Shared Neighborhood Hits	66
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
NC score	0.117381 (rank : 512)	θ value	0.47712 (rank : 404)
Query Neighborhood Hits	467	Target Neighborhood Hits	144	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SLY_HUMAN
NC score	0.117297 (rank : 513)	θ value	6.88961 (rank : 461)
Query Neighborhood Hits	467	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

MPP4_MOUSE
NC score	0.117284 (rank : 514)	θ value	0.47712 (rank : 405)
Query Neighborhood Hits	467	Target Neighborhood Hits	188	Shared Neighborhood Hits	73
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP4_HUMAN
NC score	0.116132 (rank : 515)	θ value	0.0148317 (rank : 314)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	70
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

SRMS_HUMAN
NC score	0.115207 (rank : 516)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	467	Target Neighborhood Hits	946	Shared Neighborhood Hits	95
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

P55G_HUMAN
NC score	0.114919 (rank : 517)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	467	Target Neighborhood Hits	451	Shared Neighborhood Hits	68
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PKHG1_HUMAN
NC score	0.114860 (rank : 518)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	467	Target Neighborhood Hits	174	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGG_MOUSE
NC score	0.111066 (rank : 519)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	467	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MATK_MOUSE
NC score	0.110587 (rank : 520)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	467	Target Neighborhood Hits	952	Shared Neighborhood Hits	100
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ANKF1_HUMAN
NC score	0.110296 (rank : 521)	θ value	5.27518 (rank : 449)
Query Neighborhood Hits	467	Target Neighborhood Hits	126	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

MATK_HUMAN
NC score	0.110232 (rank : 522)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	467	Target Neighborhood Hits	954	Shared Neighborhood Hits	97
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

P55G_MOUSE
NC score	0.108524 (rank : 523)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	467	Target Neighborhood Hits	401	Shared Neighborhood Hits	60
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHC3_MOUSE
NC score	0.108470 (rank : 524)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

AMPH_HUMAN
NC score	0.106707 (rank : 525)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	80
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SHC1_HUMAN
NC score	0.106384 (rank : 526)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	467	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHE_MOUSE
NC score	0.106007 (rank : 527)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	467	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MCF2L_MOUSE
NC score	0.105792 (rank : 528)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	467	Target Neighborhood Hits	255	Shared Neighborhood Hits	46
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SHC1_MOUSE
NC score	0.105632 (rank : 529)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	467	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRB14_MOUSE
NC score	0.104915 (rank : 530)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	467	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

PREX1_HUMAN
NC score	0.104850 (rank : 531)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	467	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SHC2_HUMAN
NC score	0.103613 (rank : 532)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	467	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

BMX_MOUSE
NC score	0.102955 (rank : 533)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	467	Target Neighborhood Hits	912	Shared Neighborhood Hits	71
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TIAM1_MOUSE
NC score	0.102784 (rank : 534)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SHC2_MOUSE
NC score	0.102759 (rank : 535)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	467	Target Neighborhood Hits	144	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

BMX_HUMAN
NC score	0.102543 (rank : 536)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	467	Target Neighborhood Hits	942	Shared Neighborhood Hits	73
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SHE_HUMAN
NC score	0.102293 (rank : 537)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	467	Target Neighborhood Hits	164	Shared Neighborhood Hits	48
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

GRB14_HUMAN
NC score	0.102285 (rank : 538)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

FER_HUMAN
NC score	0.101852 (rank : 539)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	467	Target Neighborhood Hits	1278	Shared Neighborhood Hits	96
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ARHG3_MOUSE
NC score	0.101634 (rank : 540)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	467	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.101484 (rank : 541)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	467	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

TIAM1_HUMAN
NC score	0.101333 (rank : 542)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	28
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SH21A_MOUSE
NC score	0.100078 (rank : 543)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	467	Target Neighborhood Hits	89	Shared Neighborhood Hits	35
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

LRRK1_HUMAN
NC score	0.099913 (rank : 544)	θ value	1.06291 (rank : 419)
Query Neighborhood Hits	467	Target Neighborhood Hits	1237	Shared Neighborhood Hits	129
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ARHG8_MOUSE
NC score	0.099550 (rank : 545)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	467	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

SHC3_HUMAN
NC score	0.099421 (rank : 546)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	467	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

APS_HUMAN
NC score	0.098725 (rank : 547)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	467	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

AMPH_MOUSE
NC score	0.098575 (rank : 548)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	467	Target Neighborhood Hits	291	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SHB_MOUSE
NC score	0.098334 (rank : 549)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SH21A_HUMAN
NC score	0.097797 (rank : 550)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	467	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

HSH2D_HUMAN
NC score	0.096737 (rank : 551)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	467	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHB_HUMAN
NC score	0.095949 (rank : 552)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	467	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ZAP70_MOUSE
NC score	0.095900 (rank : 553)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	467	Target Neighborhood Hits	905	Shared Neighborhood Hits	73
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ACK1_MOUSE
NC score	0.095464 (rank : 554)	θ value	5.27518 (rank : 448)
Query Neighborhood Hits	467	Target Neighborhood Hits	1080	Shared Neighborhood Hits	101
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ZAP70_HUMAN
NC score	0.095406 (rank : 555)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	467	Target Neighborhood Hits	893	Shared Neighborhood Hits	73
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ACK1_HUMAN
NC score	0.094573 (rank : 556)	θ value	5.27518 (rank : 447)
Query Neighborhood Hits	467	Target Neighborhood Hits	1140	Shared Neighborhood Hits	97
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ARHGG_HUMAN
NC score	0.094389 (rank : 557)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	467	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

KSYK_MOUSE
NC score	0.092711 (rank : 558)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	467	Target Neighborhood Hits	944	Shared Neighborhood Hits	73
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

BIN1_HUMAN
NC score	0.092384 (rank : 559)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	467	Target Neighborhood Hits	335	Shared Neighborhood Hits	72
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

KSYK_HUMAN
NC score	0.091800 (rank : 560)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	467	Target Neighborhood Hits	901	Shared Neighborhood Hits	72
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

GRB7_MOUSE
NC score	0.091660 (rank : 561)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	467	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SHD_MOUSE
NC score	0.091489 (rank : 562)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

BIN1_MOUSE
NC score	0.089270 (rank : 563)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	467	Target Neighborhood Hits	283	Shared Neighborhood Hits	75
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BI2L1_HUMAN
NC score	0.089235 (rank : 564)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	467	Target Neighborhood Hits	156	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SHD_HUMAN
NC score	0.089213 (rank : 565)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SASH1_HUMAN
NC score	0.089127 (rank : 566)	θ value	6.88961 (rank : 460)
Query Neighborhood Hits	467	Target Neighborhood Hits	292	Shared Neighborhood Hits	68
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

TRPV2_MOUSE
NC score	0.088738 (rank : 567)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	467	Target Neighborhood Hits	111	Shared Neighborhood Hits	80
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

ARHG8_HUMAN
NC score	0.088518 (rank : 568)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	467	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MCF2_HUMAN
NC score	0.087563 (rank : 569)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	467	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_MOUSE
NC score	0.086607 (rank : 570)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	467	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

LNK_HUMAN
NC score	0.086564 (rank : 571)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MLKL_HUMAN
NC score	0.086403 (rank : 572)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	467	Target Neighborhood Hits	600	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RUSC2_HUMAN
NC score	0.086247 (rank : 573)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	467	Target Neighborhood Hits	205	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CU081_HUMAN
NC score	0.086022 (rank : 574)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	467	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

SASH1_MOUSE
NC score	0.085936 (rank : 575)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	467	Target Neighborhood Hits	263	Shared Neighborhood Hits	62
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

RUSC2_MOUSE
NC score	0.085690 (rank : 576)	θ value	4.03905 (rank : 445)
Query Neighborhood Hits	467	Target Neighborhood Hits	305	Shared Neighborhood Hits	68
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

MPP3_MOUSE
NC score	0.085541 (rank : 577)	θ value	1.81305 (rank : 434)
Query Neighborhood Hits	467	Target Neighborhood Hits	165	Shared Neighborhood Hits	46
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

SAMN1_HUMAN
NC score	0.085384 (rank : 578)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	467	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

FES_HUMAN
NC score	0.085161 (rank : 579)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	467	Target Neighborhood Hits	978	Shared Neighborhood Hits	70
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MPP3_HUMAN
NC score	0.084820 (rank : 580)	θ value	5.27518 (rank : 454)
Query Neighborhood Hits	467	Target Neighborhood Hits	171	Shared Neighborhood Hits	47
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

EPHA1_HUMAN
NC score	0.084274 (rank : 581)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	467	Target Neighborhood Hits	997	Shared Neighborhood Hits	66
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

LNK_MOUSE
NC score	0.083795 (rank : 582)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	467	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ARHGA_HUMAN
NC score	0.083786 (rank : 583)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	467	Target Neighborhood Hits	187	Shared Neighborhood Hits	24
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

EPHA1_MOUSE
NC score	0.083654 (rank : 584)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	467	Target Neighborhood Hits	958	Shared Neighborhood Hits	63
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

FES_MOUSE
NC score	0.083266 (rank : 585)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	467	Target Neighborhood Hits	980	Shared Neighborhood Hits	67
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

EPHA5_MOUSE
NC score	0.083212 (rank : 586)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	467	Target Neighborhood Hits	950	Shared Neighborhood Hits	66
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

TNK1_HUMAN
NC score	0.082855 (rank : 587)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	467	Target Neighborhood Hits	815	Shared Neighborhood Hits	59
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

LTK_HUMAN
NC score	0.082517 (rank : 588)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	467	Target Neighborhood Hits	774	Shared Neighborhood Hits	52
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

EPHB6_HUMAN
NC score	0.082476 (rank : 589)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	467	Target Neighborhood Hits	912	Shared Neighborhood Hits	64
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

TNK1_MOUSE
NC score	0.082355 (rank : 590)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	467	Target Neighborhood Hits	806	Shared Neighborhood Hits	58
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

EPHA2_MOUSE
NC score	0.082105 (rank : 591)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	467	Target Neighborhood Hits	1020	Shared Neighborhood Hits	63
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHB6_MOUSE
NC score	0.081930 (rank : 592)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	467	Target Neighborhood Hits	906	Shared Neighborhood Hits	62
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

SAMN1_MOUSE
NC score	0.081896 (rank : 593)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	467	Target Neighborhood Hits	69	Shared Neighborhood Hits	45
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

EPHB4_HUMAN
NC score	0.081560 (rank : 594)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	467	Target Neighborhood Hits	1056	Shared Neighborhood Hits	71
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ROS_HUMAN
NC score	0.081533 (rank : 595)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	467	Target Neighborhood Hits	907	Shared Neighborhood Hits	53
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

LTK_MOUSE
NC score	0.081402 (rank : 596)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	467	Target Neighborhood Hits	770	Shared Neighborhood Hits	53
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MLKL_MOUSE
NC score	0.081392 (rank : 597)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	467	Target Neighborhood Hits	707	Shared Neighborhood Hits	51
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

EPHA2_HUMAN
NC score	0.081327 (rank : 598)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	467	Target Neighborhood Hits	1021	Shared Neighborhood Hits	63
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

DDR1_MOUSE
NC score	0.081278 (rank : 599)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	467	Target Neighborhood Hits	818	Shared Neighborhood Hits	51
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

EPHA6_HUMAN
NC score	0.081270 (rank : 600)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	467	Target Neighborhood Hits	959	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FAK2_HUMAN
NC score	0.080862 (rank : 601)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	467	Target Neighborhood Hits	847	Shared Neighborhood Hits	53
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ERBB4_HUMAN
NC score	0.080857 (rank : 602)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	467	Target Neighborhood Hits	910	Shared Neighborhood Hits	59
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EPHB4_MOUSE
NC score	0.080850 (rank : 603)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	467	Target Neighborhood Hits	1013	Shared Neighborhood Hits	68
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA6_MOUSE
NC score	0.080800 (rank : 604)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	467	Target Neighborhood Hits	946	Shared Neighborhood Hits	61
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ECT2_MOUSE
NC score	0.080782 (rank : 605)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	467	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RIPK2_HUMAN
NC score	0.080747 (rank : 606)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	467	Target Neighborhood Hits	774	Shared Neighborhood Hits	52
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

EPHA5_HUMAN
NC score	0.080690 (rank : 607)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	67
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

FAK2_MOUSE
NC score	0.080384 (rank : 608)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	467	Target Neighborhood Hits	851	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ALK_MOUSE
NC score	0.080373 (rank : 609)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	467	Target Neighborhood Hits	811	Shared Neighborhood Hits	54
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

RYK_HUMAN
NC score	0.080350 (rank : 610)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	467	Target Neighborhood Hits	701	Shared Neighborhood Hits	47
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

EPHA8_MOUSE
NC score	0.080340 (rank : 611)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	467	Target Neighborhood Hits	969	Shared Neighborhood Hits	63
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

DDR1_HUMAN
NC score	0.080240 (rank : 612)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	467	Target Neighborhood Hits	819	Shared Neighborhood Hits	51
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EPHAA_HUMAN
NC score	0.080131 (rank : 613)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	467	Target Neighborhood Hits	960	Shared Neighborhood Hits	65
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB2_HUMAN
NC score	0.079920 (rank : 614)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	467	Target Neighborhood Hits	983	Shared Neighborhood Hits	62
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

ALK_HUMAN
NC score	0.079919 (rank : 615)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	467	Target Neighborhood Hits	795	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

GRB7_HUMAN
NC score	0.079865 (rank : 616)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	467	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

EPHB3_HUMAN
NC score	0.079635 (rank : 617)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	467	Target Neighborhood Hits	996	Shared Neighborhood Hits	66
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA8_HUMAN
NC score	0.079475 (rank : 618)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	467	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

RYK_MOUSE
NC score	0.079474 (rank : 619)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	47
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

EPHB2_MOUSE
NC score	0.079427 (rank : 620)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	467	Target Neighborhood Hits	982	Shared Neighborhood Hits	62
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

GUC2G_MOUSE
NC score	0.079163 (rank : 621)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	467	Target Neighborhood Hits	644	Shared Neighborhood Hits	50
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

EPHB3_MOUSE
NC score	0.079160 (rank : 622)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	467	Target Neighborhood Hits	996	Shared Neighborhood Hits	64
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHA7_HUMAN
NC score	0.078897 (rank : 623)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	467	Target Neighborhood Hits	1053	Shared Neighborhood Hits	67
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

DLG3_HUMAN
NC score	0.078840 (rank : 624)	θ value	1.38821 (rank : 427)
Query Neighborhood Hits	467	Target Neighborhood Hits	269	Shared Neighborhood Hits	83
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

EPHB1_HUMAN
NC score	0.078791 (rank : 625)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	467	Target Neighborhood Hits	988	Shared Neighborhood Hits	66
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA7_MOUSE
NC score	0.078784 (rank : 626)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	467	Target Neighborhood Hits	1025	Shared Neighborhood Hits	64
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

LCP2_MOUSE
NC score	0.078528 (rank : 627)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	467	Target Neighborhood Hits	177	Shared Neighborhood Hits	42
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

DLG3_MOUSE
NC score	0.078337 (rank : 628)	θ value	1.38821 (rank : 428)
Query Neighborhood Hits	467	Target Neighborhood Hits	274	Shared Neighborhood Hits	83
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

IRAK3_MOUSE
NC score	0.078213 (rank : 629)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	467	Target Neighborhood Hits	628	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RON_MOUSE
NC score	0.078138 (rank : 630)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	467	Target Neighborhood Hits	836	Shared Neighborhood Hits	53
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

LCP2_HUMAN
NC score	0.078080 (rank : 631)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	467	Target Neighborhood Hits	531	Shared Neighborhood Hits	52
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

DLG1_HUMAN
NC score	0.078042 (rank : 632)	θ value	2.36792 (rank : 437)
Query Neighborhood Hits	467	Target Neighborhood Hits	290	Shared Neighborhood Hits	79
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG2_HUMAN
NC score	0.078012 (rank : 633)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	467	Target Neighborhood Hits	279	Shared Neighborhood Hits	85
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

ECT2_HUMAN
NC score	0.077980 (rank : 634)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	467	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ERBB2_MOUSE
NC score	0.077935 (rank : 635)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	467	Target Neighborhood Hits	918	Shared Neighborhood Hits	54
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB2_HUMAN
NC score	0.077862 (rank : 636)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	467	Target Neighborhood Hits	1073	Shared Neighborhood Hits	57
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EPHA4_MOUSE
NC score	0.077834 (rank : 637)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	467	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.077714 (rank : 638)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	467	Target Neighborhood Hits	975	Shared Neighborhood Hits	63
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

DLG4_HUMAN
NC score	0.077674 (rank : 639)	θ value	6.88961 (rank : 457)
Query Neighborhood Hits	467	Target Neighborhood Hits	286	Shared Neighborhood Hits	86
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

ROR2_MOUSE
NC score	0.077637 (rank : 640)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	467	Target Neighborhood Hits	1000	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

MERTK_MOUSE
NC score	0.077563 (rank : 641)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	467	Target Neighborhood Hits	974	Shared Neighborhood Hits	50
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_HUMAN
NC score	0.077446 (rank : 642)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	467	Target Neighborhood Hits	988	Shared Neighborhood Hits	51
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

RON_HUMAN
NC score	0.077427 (rank : 643)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	467	Target Neighborhood Hits	842	Shared Neighborhood Hits	53
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DLG2_MOUSE
NC score	0.077407 (rank : 644)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	467	Target Neighborhood Hits	271	Shared Neighborhood Hits	85
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

FAK1_HUMAN
NC score	0.077261 (rank : 645)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	467	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

STYK1_HUMAN
NC score	0.077254 (rank : 646)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	467	Target Neighborhood Hits	786	Shared Neighborhood Hits	51
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

FAK1_MOUSE
NC score	0.077138 (rank : 647)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	467	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

SH2D3_MOUSE
NC score	0.076873 (rank : 648)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	467	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

IGF1R_MOUSE
NC score	0.076747 (rank : 649)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	467	Target Neighborhood Hits	973	Shared Neighborhood Hits	54
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MLTK_MOUSE
NC score	0.076718 (rank : 650)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.076690 (rank : 651)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	467	Target Neighborhood Hits	911	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

UFO_MOUSE
NC score	0.076638 (rank : 652)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	467	Target Neighborhood Hits	988	Shared Neighborhood Hits	54
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

MET_MOUSE
NC score	0.076613 (rank : 653)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	467	Target Neighborhood Hits	844	Shared Neighborhood Hits	54
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

INSRR_MOUSE
NC score	0.076563 (rank : 654)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	467	Target Neighborhood Hits	961	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

IGF1R_HUMAN
NC score	0.076515 (rank : 655)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	467	Target Neighborhood Hits	977	Shared Neighborhood Hits	55
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MET_HUMAN
NC score	0.076508 (rank : 656)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	467	Target Neighborhood Hits	831	Shared Neighborhood Hits	52
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

INSR_HUMAN
NC score	0.076489 (rank : 657)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	467	Target Neighborhood Hits	963	Shared Neighborhood Hits	58
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

RET_HUMAN
NC score	0.076466 (rank : 658)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	467	Target Neighborhood Hits	873	Shared Neighborhood Hits	51
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

NTRK1_HUMAN
NC score	0.076396 (rank : 659)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	467	Target Neighborhood Hits	1023	Shared Neighborhood Hits	51
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

UFO_HUMAN
NC score	0.076357 (rank : 660)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	467	Target Neighborhood Hits	981	Shared Neighborhood Hits	52
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

SH24A_HUMAN
NC score	0.076246 (rank : 661)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	467	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

GRB10_MOUSE
NC score	0.076191 (rank : 662)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	467	Target Neighborhood Hits	156	Shared Neighborhood Hits	47
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

INSRR_HUMAN
NC score	0.076178 (rank : 663)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	467	Target Neighborhood Hits	950	Shared Neighborhood Hits	60
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

RET_MOUSE
NC score	0.076166 (rank : 664)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	467	Target Neighborhood Hits	884	Shared Neighborhood Hits	53
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

DDR2_HUMAN
NC score	0.076159 (rank : 665)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	467	Target Neighborhood Hits	818	Shared Neighborhood Hits	53
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EGFR_HUMAN
NC score	0.076122 (rank : 666)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	467	Target Neighborhood Hits	939	Shared Neighborhood Hits	54
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

CSKP_HUMAN
NC score	0.076094 (rank : 667)	θ value	0.163984 (rank : 386)
Query Neighborhood Hits	467	Target Neighborhood Hits	1022	Shared Neighborhood Hits	141
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

IRAK3_HUMAN
NC score	0.076070 (rank : 668)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	467	Target Neighborhood Hits	644	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

DLG1_MOUSE
NC score	0.076018 (rank : 669)	θ value	3.0926 (rank : 439)
Query Neighborhood Hits	467	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

EGFR_MOUSE
NC score	0.075947 (rank : 670)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	467	Target Neighborhood Hits	927	Shared Neighborhood Hits	53
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

MOS_HUMAN
NC score	0.075913 (rank : 671)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	467	Target Neighborhood Hits	829	Shared Neighborhood Hits	52
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ROR2_HUMAN
NC score	0.075897 (rank : 672)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	467	Target Neighborhood Hits	1014	Shared Neighborhood Hits	55
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

TIE2_HUMAN
NC score	0.075844 (rank : 673)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	467	Target Neighborhood Hits	1192	Shared Neighborhood Hits	63
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE1_HUMAN
NC score	0.075695 (rank : 674)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	467	Target Neighborhood Hits	1241	Shared Neighborhood Hits	60
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

RAF1_HUMAN
NC score	0.075654 (rank : 675)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	467	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

AATK_MOUSE
NC score	0.075570 (rank : 676)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	467	Target Neighborhood Hits	942	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

TIE1_MOUSE
NC score	0.075536 (rank : 677)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	467	Target Neighborhood Hits	1266	Shared Neighborhood Hits	60
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CSKP_MOUSE
NC score	0.075532 (rank : 678)	θ value	0.0736092 (rank : 358)
Query Neighborhood Hits	467	Target Neighborhood Hits	1027	Shared Neighborhood Hits	148
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

TIE2_MOUSE
NC score	0.075511 (rank : 679)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	467	Target Neighborhood Hits	1204	Shared Neighborhood Hits	63
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

MOS_MOUSE
NC score	0.075443 (rank : 680)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	467	Target Neighborhood Hits	833	Shared Neighborhood Hits	52
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ANPRB_MOUSE
NC score	0.075411 (rank : 681)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	467	Target Neighborhood Hits	607	Shared Neighborhood Hits	47
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

IRAK2_HUMAN
NC score	0.075368 (rank : 682)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	467	Target Neighborhood Hits	714	Shared Neighborhood Hits	48
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ERBB3_HUMAN
NC score	0.075361 (rank : 683)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	467	Target Neighborhood Hits	918	Shared Neighborhood Hits	58
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

STYK1_MOUSE
NC score	0.075359 (rank : 684)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	467	Target Neighborhood Hits	779	Shared Neighborhood Hits	49
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ERBB3_MOUSE
NC score	0.075173 (rank : 685)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	467	Target Neighborhood Hits	898	Shared Neighborhood Hits	57
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ROR1_MOUSE
NC score	0.075165 (rank : 686)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	467	Target Neighborhood Hits	1025	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

DDR2_MOUSE
NC score	0.075146 (rank : 687)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	467	Target Neighborhood Hits	813	Shared Neighborhood Hits	51
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

TYRO3_MOUSE
NC score	0.075035 (rank : 688)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	467	Target Neighborhood Hits	1007	Shared Neighborhood Hits	52
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

RIPK2_MOUSE
NC score	0.075003 (rank : 689)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	467	Target Neighborhood Hits	776	Shared Neighborhood Hits	50
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

ROR1_HUMAN
NC score	0.074988 (rank : 690)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	467	Target Neighborhood Hits	1018	Shared Neighborhood Hits	52
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

RAF1_MOUSE
NC score	0.074931 (rank : 691)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	467	Target Neighborhood Hits	886	Shared Neighborhood Hits	61
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

BRAF1_HUMAN
NC score	0.074917 (rank : 692)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	467	Target Neighborhood Hits	883	Shared Neighborhood Hits	62
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

INSR_MOUSE
NC score	0.074871 (rank : 693)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	467	Target Neighborhood Hits	968	Shared Neighborhood Hits	55
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHA3_HUMAN
NC score	0.074798 (rank : 694)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	467	Target Neighborhood Hits	1005	Shared Neighborhood Hits	59
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

TYRO3_HUMAN
NC score	0.074689 (rank : 695)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	467	Target Neighborhood Hits	995	Shared Neighborhood Hits	51
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHA3_MOUSE
NC score	0.074543 (rank : 696)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	467	Target Neighborhood Hits	1009	Shared Neighborhood Hits	59
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

GRB10_HUMAN
NC score	0.074333 (rank : 697)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	467	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

DLG4_MOUSE
NC score	0.074262 (rank : 698)	θ value	6.88961 (rank : 458)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	82
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

APS_MOUSE
NC score	0.074161 (rank : 699)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	467	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

PTN11_MOUSE
NC score	0.074048 (rank : 700)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.074035 (rank : 701)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

BAIP2_MOUSE
NC score	0.073991 (rank : 702)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	467	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

FLT3_MOUSE
NC score	0.073958 (rank : 703)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	467	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

AATK_HUMAN
NC score	0.073860 (rank : 704)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	467	Target Neighborhood Hits	1243	Shared Neighborhood Hits	60
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

NTRK3_HUMAN
NC score	0.073715 (rank : 705)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	467	Target Neighborhood Hits	1115	Shared Neighborhood Hits	52
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

KSR2_HUMAN
NC score	0.073635 (rank : 706)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	467	Target Neighborhood Hits	920	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

FLT3_HUMAN
NC score	0.073628 (rank : 707)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	467	Target Neighborhood Hits	843	Shared Neighborhood Hits	52
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

CHIN_MOUSE
NC score	0.073214 (rank : 708)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	467	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ANPRB_HUMAN
NC score	0.073182 (rank : 709)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	467	Target Neighborhood Hits	646	Shared Neighborhood Hits	47
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
NC score	0.073108 (rank : 710)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	467	Target Neighborhood Hits	924	Shared Neighborhood Hits	64
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BAIP2_HUMAN
NC score	0.072988 (rank : 711)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	467	Target Neighborhood Hits	192	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ARAF_MOUSE
NC score	0.072977 (rank : 712)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

KIT_MOUSE
NC score	0.072931 (rank : 713)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	467	Target Neighborhood Hits	949	Shared Neighborhood Hits	52
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_HUMAN
NC score	0.072823 (rank : 714)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	467	Target Neighborhood Hits	953	Shared Neighborhood Hits	51
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

GUC2F_HUMAN
NC score	0.072743 (rank : 715)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	467	Target Neighborhood Hits	740	Shared Neighborhood Hits	47
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

M3K7_HUMAN
NC score	0.072721 (rank : 716)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	467	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
NC score	0.072714 (rank : 717)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	467	Target Neighborhood Hits	892	Shared Neighborhood Hits	52
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

NTRK2_HUMAN
NC score	0.072271 (rank : 718)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	467	Target Neighborhood Hits	1081	Shared Neighborhood Hits	52
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.072267 (rank : 719)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	467	Target Neighborhood Hits	1088	Shared Neighborhood Hits	52
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

FGFR4_MOUSE
NC score	0.072205 (rank : 720)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	467	Target Neighborhood Hits	1026	Shared Neighborhood Hits	52
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

IRAK1_MOUSE
NC score	0.072155 (rank : 721)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	467	Target Neighborhood Hits	784	Shared Neighborhood Hits	50
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

PGFRA_MOUSE
NC score	0.072139 (rank : 722)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	467	Target Neighborhood Hits	975	Shared Neighborhood Hits	53
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

M3K12_HUMAN
NC score	0.072043 (rank : 723)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	467	Target Neighborhood Hits	940	Shared Neighborhood Hits	57
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

GUC2C_HUMAN
NC score	0.071994 (rank : 724)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	467	Target Neighborhood Hits	624	Shared Neighborhood Hits	49
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

CSF1R_HUMAN
NC score	0.071984 (rank : 725)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	467	Target Neighborhood Hits	943	Shared Neighborhood Hits	51
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

M3K12_MOUSE
NC score	0.071953 (rank : 726)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	467	Target Neighborhood Hits	957	Shared Neighborhood Hits	56
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

PGFRB_MOUSE
NC score	0.071935 (rank : 727)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	467	Target Neighborhood Hits	960	Shared Neighborhood Hits	53
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRA_HUMAN
NC score	0.071777 (rank : 728)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	467	Target Neighborhood Hits	980	Shared Neighborhood Hits	53
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

SOCS7_MOUSE
NC score	0.071764 (rank : 729)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	467	Target Neighborhood Hits	154	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

PGFRB_HUMAN
NC score	0.071694 (rank : 730)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	467	Target Neighborhood Hits	962	Shared Neighborhood Hits	51
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

IRAK1_HUMAN
NC score	0.071680 (rank : 731)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	467	Target Neighborhood Hits	820	Shared Neighborhood Hits	52
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

RIPK1_HUMAN
NC score	0.071621 (rank : 732)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	467	Target Neighborhood Hits	891	Shared Neighborhood Hits	56
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

CHIN_HUMAN
NC score	0.071468 (rank : 733)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ANPRA_MOUSE
NC score	0.071374 (rank : 734)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	467	Target Neighborhood Hits	600	Shared Neighborhood Hits	46
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

KSR1_HUMAN
NC score	0.071295 (rank : 735)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	467	Target Neighborhood Hits	867	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

RIPK3_MOUSE
NC score	0.071246 (rank : 736)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	467	Target Neighborhood Hits	867	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

M3K13_HUMAN
NC score	0.071241 (rank : 737)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	467	Target Neighborhood Hits	911	Shared Neighborhood Hits	54
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

RIPK1_MOUSE
NC score	0.071171 (rank : 738)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	56
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

HAPIP_HUMAN
NC score	0.071046 (rank : 739)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	467	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FGD4_MOUSE
NC score	0.070968 (rank : 740)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	467	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGFR4_HUMAN
NC score	0.070957 (rank : 741)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	467	Target Neighborhood Hits	1037	Shared Neighborhood Hits	52
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

ANPRA_HUMAN
NC score	0.070901 (rank : 742)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	467	Target Neighborhood Hits	612	Shared Neighborhood Hits	46
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

CSF1R_MOUSE
NC score	0.070562 (rank : 743)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	467	Target Neighborhood Hits	983	Shared Neighborhood Hits	51
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

JAK1_HUMAN
NC score	0.070497 (rank : 744)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	467	Target Neighborhood Hits	858	Shared Neighborhood Hits	53
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

CHIO_HUMAN
NC score	0.070350 (rank : 745)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	467	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SH2D3_HUMAN
NC score	0.070333 (rank : 746)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	467	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

JAK1_MOUSE
NC score	0.070210 (rank : 747)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	467	Target Neighborhood Hits	854	Shared Neighborhood Hits	52
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

SH22A_MOUSE
NC score	0.070056 (rank : 748)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	467	Target Neighborhood Hits	179	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

KSR1_MOUSE
NC score	0.069733 (rank : 749)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	467	Target Neighborhood Hits	870	Shared Neighborhood Hits	55
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

ARHGC_HUMAN
NC score	0.069319 (rank : 750)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	467	Target Neighborhood Hits	351	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TYK2_MOUSE
NC score	0.069281 (rank : 751)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	467	Target Neighborhood Hits	850	Shared Neighborhood Hits	52
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

ARHGC_MOUSE
NC score	0.069045 (rank : 752)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	467	Target Neighborhood Hits	344	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TYK2_HUMAN
NC score	0.068922 (rank : 753)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	467	Target Neighborhood Hits	841	Shared Neighborhood Hits	52
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

BCR_HUMAN
NC score	0.068490 (rank : 754)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	30
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

GUC2E_MOUSE
NC score	0.068318 (rank : 755)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	467	Target Neighborhood Hits	692	Shared Neighborhood Hits	47
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

FGFR3_HUMAN
NC score	0.068308 (rank : 756)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	467	Target Neighborhood Hits	1042	Shared Neighborhood Hits	53
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

TRPC6_HUMAN
NC score	0.068207 (rank : 757)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	467	Target Neighborhood Hits	171	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

RIPK3_HUMAN
NC score	0.068170 (rank : 758)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	467	Target Neighborhood Hits	828	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

ARHGB_HUMAN
NC score	0.068116 (rank : 759)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	467	Target Neighborhood Hits	375	Shared Neighborhood Hits	38
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

MUSK_HUMAN
NC score	0.068092 (rank : 760)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	467	Target Neighborhood Hits	1074	Shared Neighborhood Hits	51
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
NC score	0.067827 (rank : 761)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	467	Target Neighborhood Hits	1057	Shared Neighborhood Hits	51
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

FGFR3_MOUSE
NC score	0.067772 (rank : 762)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	467	Target Neighborhood Hits	1059	Shared Neighborhood Hits	52
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGD4_HUMAN
NC score	0.067668 (rank : 763)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	467	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

GUC2D_HUMAN
NC score	0.067543 (rank : 764)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

BMR1B_MOUSE
NC score	0.067315 (rank : 765)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	467	Target Neighborhood Hits	758	Shared Neighborhood Hits	49
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

JAK3_HUMAN
NC score	0.067269 (rank : 766)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	467	Target Neighborhood Hits	827	Shared Neighborhood Hits	52
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

TOPK_HUMAN
NC score	0.066985 (rank : 767)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	467	Target Neighborhood Hits	605	Shared Neighborhood Hits	48
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TRIO_HUMAN
NC score	0.066954 (rank : 768)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	467	Target Neighborhood Hits	1580	Shared Neighborhood Hits	106
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

AMHR2_HUMAN
NC score	0.066926 (rank : 769)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	45
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

FGFR2_MOUSE
NC score	0.066912 (rank : 770)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	467	Target Neighborhood Hits	1062	Shared Neighborhood Hits	52
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

BMR1B_HUMAN
NC score	0.066758 (rank : 771)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	467	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

FGFR2_HUMAN
NC score	0.066481 (rank : 772)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	467	Target Neighborhood Hits	1062	Shared Neighborhood Hits	52
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR1_MOUSE
NC score	0.066475 (rank : 773)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	467	Target Neighborhood Hits	1068	Shared Neighborhood Hits	52
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.066461 (rank : 774)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	467	Target Neighborhood Hits	1069	Shared Neighborhood Hits	52
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

VGFR3_MOUSE
NC score	0.066435 (rank : 775)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	467	Target Neighborhood Hits	1056	Shared Neighborhood Hits	51
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_HUMAN
NC score	0.066426 (rank : 776)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	467	Target Neighborhood Hits	1037	Shared Neighborhood Hits	52
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

PTK7_HUMAN
NC score	0.066266 (rank : 777)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	467	Target Neighborhood Hits	1103	Shared Neighborhood Hits	51
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

BI2L1_MOUSE
NC score	0.066259 (rank : 778)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	467	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

JAK2_HUMAN
NC score	0.066198 (rank : 779)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	467	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ARHG1_HUMAN
NC score	0.066102 (rank : 780)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	467	Target Neighborhood Hits	176	Shared Neighborhood Hits	18
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

JAK2_MOUSE
NC score	0.065998 (rank : 781)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	467	Target Neighborhood Hits	839	Shared Neighborhood Hits	52
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

FGD3_MOUSE
NC score	0.065687 (rank : 782)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	467	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TRPV4_HUMAN
NC score	0.065310 (rank : 783)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	467	Target Neighborhood Hits	150	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

FGD2_HUMAN
NC score	0.064781 (rank : 784)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	467	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

BMR1A_MOUSE
NC score	0.064681 (rank : 785)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	467	Target Neighborhood Hits	758	Shared Neighborhood Hits	50
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

TESK2_HUMAN
NC score	0.064522 (rank : 786)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	467	Target Neighborhood Hits	851	Shared Neighborhood Hits	53
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

RHG12_MOUSE
NC score	0.064482 (rank : 787)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	467	Target Neighborhood Hits	204	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

BMR1A_HUMAN
NC score	0.064354 (rank : 788)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	467	Target Neighborhood Hits	759	Shared Neighborhood Hits	50
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

JAK3_MOUSE
NC score	0.064143 (rank : 789)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	467	Target Neighborhood Hits	821	Shared Neighborhood Hits	52
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

TOPK_MOUSE
NC score	0.063932 (rank : 790)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	467	Target Neighborhood Hits	618	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

IRAK4_HUMAN
NC score	0.063694 (rank : 791)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	467	Target Neighborhood Hits	816	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

GNRP_MOUSE
NC score	0.063589 (rank : 792)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	467	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

VGFR1_HUMAN
NC score	0.063392 (rank : 793)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	467	Target Neighborhood Hits	1109	Shared Neighborhood Hits	52
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR2_MOUSE
NC score	0.063382 (rank : 794)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	467	Target Neighborhood Hits	1089	Shared Neighborhood Hits	51
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

PTN6_MOUSE
NC score	0.063124 (rank : 795)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

TESK2_MOUSE
NC score	0.063121 (rank : 796)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	467	Target Neighborhood Hits	833	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

VGFR1_MOUSE
NC score	0.063082 (rank : 797)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	467	Target Neighborhood Hits	1118	Shared Neighborhood Hits	51
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
NC score	0.062566 (rank : 798)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	467	Target Neighborhood Hits	1103	Shared Neighborhood Hits	51
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

RGNEF_MOUSE
NC score	0.062467 (rank : 799)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	467	Target Neighborhood Hits	641	Shared Neighborhood Hits	43
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

PTN6_HUMAN
NC score	0.062350 (rank : 800)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	467	Target Neighborhood Hits	234	Shared Neighborhood Hits	52
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

ACVL1_MOUSE
NC score	0.062005 (rank : 801)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	467	Target Neighborhood Hits	739	Shared Neighborhood Hits	45
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_HUMAN
NC score	0.061921 (rank : 802)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	467	Target Neighborhood Hits	716	Shared Neighborhood Hits	45
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

LBC_HUMAN
NC score	0.061722 (rank : 803)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	467	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

IRAK4_MOUSE
NC score	0.061629 (rank : 804)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	467	Target Neighborhood Hits	820	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

SH22A_HUMAN
NC score	0.061264 (rank : 805)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	467	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

LIMK1_MOUSE
NC score	0.061028 (rank : 806)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	467	Target Neighborhood Hits	1008	Shared Neighborhood Hits	67
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RHG12_HUMAN
NC score	0.060876 (rank : 807)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	467	Target Neighborhood Hits	190	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PKHG4_HUMAN
NC score	0.060810 (rank : 808)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	467	Target Neighborhood Hits	200	Shared Neighborhood Hits	22
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

LIMK1_HUMAN
NC score	0.060675 (rank : 809)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	467	Target Neighborhood Hits	1005	Shared Neighborhood Hits	67
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

BCAR3_HUMAN
NC score	0.060651 (rank : 810)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	467	Target Neighborhood Hits	129	Shared Neighborhood Hits	36
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

FGD2_MOUSE
NC score	0.060234 (rank : 811)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	467	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ACVR1_HUMAN
NC score	0.060135 (rank : 812)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	467	Target Neighborhood Hits	760	Shared Neighborhood Hits	49
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

TESK1_HUMAN
NC score	0.060102 (rank : 813)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	467	Target Neighborhood Hits	864	Shared Neighborhood Hits	56
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

GNRP_HUMAN
NC score	0.059825 (rank : 814)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	467	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

TESK1_MOUSE
NC score	0.059738 (rank : 815)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	467	Target Neighborhood Hits	862	Shared Neighborhood Hits	54
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TGFR1_HUMAN
NC score	0.059652 (rank : 816)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	467	Target Neighborhood Hits	755	Shared Neighborhood Hits	51
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

FGD3_HUMAN
NC score	0.059630 (rank : 817)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	467	Target Neighborhood Hits	249	Shared Neighborhood Hits	23
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

BLNK_MOUSE
NC score	0.059620 (rank : 818)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

TGFR1_MOUSE
NC score	0.059570 (rank : 819)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	467	Target Neighborhood Hits	753	Shared Neighborhood Hits	51
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

BCAR3_MOUSE
NC score	0.059457 (rank : 820)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	467	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ACVR1_MOUSE
NC score	0.059445 (rank : 821)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	467	Target Neighborhood Hits	768	Shared Neighborhood Hits	49
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

KGUA_HUMAN
NC score	0.059376 (rank : 822)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	467	Target Neighborhood Hits	41	Shared Neighborhood Hits	21
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
NC score	0.059328 (rank : 823)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	467	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

ABR_HUMAN
NC score	0.059043 (rank : 824)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	467	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RIPK5_MOUSE
NC score	0.058969 (rank : 825)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	467	Target Neighborhood Hits	874	Shared Neighborhood Hits	53
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RHG09_HUMAN
NC score	0.058900 (rank : 826)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	467	Target Neighborhood Hits	186	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

ARHG1_MOUSE
NC score	0.058727 (rank : 827)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	467	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RIPK5_HUMAN
NC score	0.058648 (rank : 828)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	467	Target Neighborhood Hits	864	Shared Neighborhood Hits	54
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

TRPV4_MOUSE
NC score	0.058297 (rank : 829)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	467	Target Neighborhood Hits	117	Shared Neighborhood Hits	65
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

PPIP2_HUMAN
NC score	0.058216 (rank : 830)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	467	Target Neighborhood Hits	254	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

LRRK2_MOUSE
NC score	0.058161 (rank : 831)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	467	Target Neighborhood Hits	1359	Shared Neighborhood Hits	72
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

ARHGF_HUMAN
NC score	0.058055 (rank : 832)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	467	Target Neighborhood Hits	214	Shared Neighborhood Hits	24
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

DUET_HUMAN
NC score	0.057933 (rank : 833)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	467	Target Neighborhood Hits	1220	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ACV1B_HUMAN
NC score	0.057932 (rank : 834)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	467	Target Neighborhood Hits	753	Shared Neighborhood Hits	50
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1C_MOUSE
NC score	0.057805 (rank : 835)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	467	Target Neighborhood Hits	715	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

SH24A_MOUSE
NC score	0.057652 (rank : 836)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	467	Target Neighborhood Hits	326	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

ACV1B_MOUSE
NC score	0.057638 (rank : 837)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	467	Target Neighborhood Hits	753	Shared Neighborhood Hits	49
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ARHG2_HUMAN
NC score	0.057555 (rank : 838)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	467	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

LIMK2_HUMAN
NC score	0.057541 (rank : 839)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	467	Target Neighborhood Hits	986	Shared Neighborhood Hits	68
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
NC score	0.057320 (rank : 840)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	467	Target Neighborhood Hits	998	Shared Neighborhood Hits	66
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ACV1C_HUMAN
NC score	0.057230 (rank : 841)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	467	Target Neighborhood Hits	709	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

LRRK2_HUMAN
NC score	0.056529 (rank : 842)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	467	Target Neighborhood Hits	1382	Shared Neighborhood Hits	64
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

HSH2D_MOUSE
NC score	0.056349 (rank : 843)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	467	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

FGD1_HUMAN
NC score	0.056197 (rank : 844)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	467	Target Neighborhood Hits	367	Shared Neighborhood Hits	37
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TENS4_MOUSE
NC score	0.056102 (rank : 845)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	467	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

SH23A_HUMAN
NC score	0.055943 (rank : 846)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	467	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

BLNK_HUMAN
NC score	0.055581 (rank : 847)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	467	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

DLG5_HUMAN
NC score	0.054826 (rank : 848)	θ value	1.81305 (rank : 431)
Query Neighborhood Hits	467	Target Neighborhood Hits	1088	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ARHG2_MOUSE
NC score	0.054814 (rank : 849)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	467	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

WNK2_HUMAN
NC score	0.054646 (rank : 850)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	467	Target Neighborhood Hits	1407	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

TRPC3_HUMAN
NC score	0.054480 (rank : 851)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	467	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

FGD1_MOUSE
NC score	0.053486 (rank : 852)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	467	Target Neighborhood Hits	387	Shared Neighborhood Hits	34
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FARP2_MOUSE
NC score	0.052840 (rank : 853)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	467	Target Neighborhood Hits	209	Shared Neighborhood Hits	24
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PPIP2_MOUSE
NC score	0.052541 (rank : 854)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	467	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

TAOK1_HUMAN
NC score	0.052309 (rank : 855)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	467	Target Neighborhood Hits	1734	Shared Neighborhood Hits	86
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
NC score	0.052089 (rank : 856)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	467	Target Neighborhood Hits	1720	Shared Neighborhood Hits	86
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

AVR2B_MOUSE
NC score	0.051539 (rank : 857)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	467	Target Neighborhood Hits	749	Shared Neighborhood Hits	49
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.051463 (rank : 858)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	467	Target Neighborhood Hits	748	Shared Neighborhood Hits	49
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

SOCS2_HUMAN
NC score	0.051217 (rank : 859)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	467	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS6_MOUSE
NC score	0.050982 (rank : 860)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	467	Target Neighborhood Hits	146	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

AVR2A_MOUSE
NC score	0.050970 (rank : 861)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	467	Target Neighborhood Hits	767	Shared Neighborhood Hits	49
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.050968 (rank : 862)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	467	Target Neighborhood Hits	767	Shared Neighborhood Hits	49
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

SOCS6_HUMAN
NC score	0.050453 (rank : 863)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	467	Target Neighborhood Hits	126	Shared Neighborhood Hits	39
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

FGD6_MOUSE
NC score	0.050236 (rank : 864)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	467	Target Neighborhood Hits	282	Shared Neighborhood Hits	26
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SOCS2_MOUSE
NC score	0.050168 (rank : 865)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	467	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

BMPR2_HUMAN
NC score	0.050158 (rank : 866)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	467	Target Neighborhood Hits	736	Shared Neighborhood Hits	49
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

YSK4_HUMAN
NC score	0.050106 (rank : 867)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	467	Target Neighborhood Hits	921	Shared Neighborhood Hits	59
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

3BP1_HUMAN
NC score	0.050044 (rank : 868)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	467	Target Neighborhood Hits	376	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

NEK11_HUMAN
NC score	0.050024 (rank : 869)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	467	Target Neighborhood Hits	1043	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

S3TC1_HUMAN
NC score	0.034653 (rank : 870)	θ value	4.03905 (rank : 446)
Query Neighborhood Hits	467	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

ZO2_MOUSE
NC score	0.023223 (rank : 871)	θ value	8.99809 (rank : 467)
Query Neighborhood Hits	467	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

CCD94_MOUSE
NC score	0.020695 (rank : 872)	θ value	8.99809 (rank : 464)
Query Neighborhood Hits	467	Target Neighborhood Hits	127	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D6J3	Gene names	Ccdc94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.