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Network neighborhood for query Sequence : ARHGC_HUMAN

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ARHGC_HUMAN
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHGC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	351	Target Neighborhood Hits	351	Shared Neighborhood Hits	351
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	0 (rank : 2)	NC score	0.989637 (rank : 2)
Query Neighborhood Hits	351	Target Neighborhood Hits	344	Shared Neighborhood Hits	271
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_MOUSE
θ value	1.28662e-147 (rank : 3)	NC score	0.842185 (rank : 5)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	67
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG1_HUMAN
θ value	3.41741e-116 (rank : 4)	NC score	0.860930 (rank : 4)
Query Neighborhood Hits	351	Target Neighborhood Hits	176	Shared Neighborhood Hits	66
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHGB_HUMAN
θ value	4.1775e-114 (rank : 5)	NC score	0.922384 (rank : 3)
Query Neighborhood Hits	351	Target Neighborhood Hits	375	Shared Neighborhood Hits	208
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

LBC_HUMAN
θ value	2.11701e-41 (rank : 6)	NC score	0.787216 (rank : 6)
Query Neighborhood Hits	351	Target Neighborhood Hits	90	Shared Neighborhood Hits	61
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

RGNEF_MOUSE
θ value	2.11701e-41 (rank : 7)	NC score	0.667247 (rank : 9)
Query Neighborhood Hits	351	Target Neighborhood Hits	641	Shared Neighborhood Hits	125
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG2_MOUSE
θ value	8.04462e-41 (rank : 8)	NC score	0.770334 (rank : 7)
Query Neighborhood Hits	351	Target Neighborhood Hits	120	Shared Neighborhood Hits	67
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
θ value	3.05695e-40 (rank : 9)	NC score	0.758059 (rank : 8)
Query Neighborhood Hits	351	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ITSN2_HUMAN
θ value	4.14116e-29 (rank : 10)	NC score	0.470165 (rank : 38)
Query Neighborhood Hits	351	Target Neighborhood Hits	1173	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	1.33217e-27 (rank : 11)	NC score	0.447962 (rank : 43)
Query Neighborhood Hits	351	Target Neighborhood Hits	1371	Shared Neighborhood Hits	155
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
θ value	6.61148e-27 (rank : 12)	NC score	0.431551 (rank : 46)
Query Neighborhood Hits	351	Target Neighborhood Hits	1757	Shared Neighborhood Hits	162
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	6.61148e-27 (rank : 13)	NC score	0.430576 (rank : 47)
Query Neighborhood Hits	351	Target Neighborhood Hits	1669	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG8_MOUSE
θ value	8.65492e-19 (rank : 14)	NC score	0.641012 (rank : 14)
Query Neighborhood Hits	351	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG8_HUMAN
θ value	1.63225e-17 (rank : 15)	NC score	0.646627 (rank : 12)
Query Neighborhood Hits	351	Target Neighborhood Hits	85	Shared Neighborhood Hits	62
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG3_HUMAN
θ value	2.13179e-17 (rank : 16)	NC score	0.659847 (rank : 10)
Query Neighborhood Hits	351	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	8.10077e-17 (rank : 17)	NC score	0.659546 (rank : 11)
Query Neighborhood Hits	351	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

NGEF_MOUSE
θ value	3.07829e-16 (rank : 18)	NC score	0.608032 (rank : 19)
Query Neighborhood Hits	351	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
θ value	5.25075e-16 (rank : 19)	NC score	0.614149 (rank : 16)
Query Neighborhood Hits	351	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

VAV_HUMAN
θ value	6.85773e-16 (rank : 20)	NC score	0.446072 (rank : 44)
Query Neighborhood Hits	351	Target Neighborhood Hits	452	Shared Neighborhood Hits	74
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	6.85773e-16 (rank : 21)	NC score	0.459925 (rank : 39)
Query Neighborhood Hits	351	Target Neighborhood Hits	430	Shared Neighborhood Hits	72
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHGG_HUMAN
θ value	2.60593e-15 (rank : 22)	NC score	0.642912 (rank : 13)
Query Neighborhood Hits	351	Target Neighborhood Hits	129	Shared Neighborhood Hits	66
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ECT2_MOUSE
θ value	1.68911e-14 (rank : 23)	NC score	0.612015 (rank : 18)
Query Neighborhood Hits	351	Target Neighborhood Hits	98	Shared Neighborhood Hits	68
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGG_MOUSE
θ value	2.88119e-14 (rank : 24)	NC score	0.630488 (rank : 15)
Query Neighborhood Hits	351	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD4_HUMAN
θ value	1.09485e-13 (rank : 25)	NC score	0.519705 (rank : 29)
Query Neighborhood Hits	351	Target Neighborhood Hits	219	Shared Neighborhood Hits	75
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ECT2_HUMAN
θ value	5.43371e-13 (rank : 26)	NC score	0.595982 (rank : 20)
Query Neighborhood Hits	351	Target Neighborhood Hits	98	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV2_HUMAN
θ value	7.09661e-13 (rank : 27)	NC score	0.457078 (rank : 40)
Query Neighborhood Hits	351	Target Neighborhood Hits	453	Shared Neighborhood Hits	72
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	1.58096e-12 (rank : 28)	NC score	0.428794 (rank : 49)
Query Neighborhood Hits	351	Target Neighborhood Hits	398	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG5_HUMAN
θ value	3.52202e-12 (rank : 29)	NC score	0.613095 (rank : 17)
Query Neighborhood Hits	351	Target Neighborhood Hits	172	Shared Neighborhood Hits	67
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD4_MOUSE
θ value	3.52202e-12 (rank : 30)	NC score	0.516911 (rank : 30)
Query Neighborhood Hits	351	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_MOUSE
θ value	6.00763e-12 (rank : 31)	NC score	0.494309 (rank : 36)
Query Neighborhood Hits	351	Target Neighborhood Hits	387	Shared Neighborhood Hits	74
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

VAV3_MOUSE
θ value	6.00763e-12 (rank : 32)	NC score	0.429827 (rank : 48)
Query Neighborhood Hits	351	Target Neighborhood Hits	404	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
θ value	7.84624e-12 (rank : 33)	NC score	0.454229 (rank : 41)
Query Neighborhood Hits	351	Target Neighborhood Hits	456	Shared Neighborhood Hits	73
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHGF_HUMAN
θ value	2.28291e-11 (rank : 34)	NC score	0.587107 (rank : 21)
Query Neighborhood Hits	351	Target Neighborhood Hits	214	Shared Neighborhood Hits	64
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FGD2_MOUSE
θ value	3.89403e-11 (rank : 35)	NC score	0.509953 (rank : 33)
Query Neighborhood Hits	351	Target Neighborhood Hits	163	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG9_HUMAN
θ value	5.08577e-11 (rank : 36)	NC score	0.527936 (rank : 27)
Query Neighborhood Hits	351	Target Neighborhood Hits	235	Shared Neighborhood Hits	76
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	5.08577e-11 (rank : 37)	NC score	0.527449 (rank : 28)
Query Neighborhood Hits	351	Target Neighborhood Hits	234	Shared Neighborhood Hits	76
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGD1_HUMAN
θ value	6.64225e-11 (rank : 38)	NC score	0.490425 (rank : 37)
Query Neighborhood Hits	351	Target Neighborhood Hits	367	Shared Neighborhood Hits	75
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG4_MOUSE
θ value	2.52405e-10 (rank : 39)	NC score	0.534373 (rank : 25)
Query Neighborhood Hits	351	Target Neighborhood Hits	185	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_HUMAN
θ value	9.59137e-10 (rank : 40)	NC score	0.511194 (rank : 31)
Query Neighborhood Hits	351	Target Neighborhood Hits	249	Shared Neighborhood Hits	67
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHG4_HUMAN
θ value	1.63604e-09 (rank : 41)	NC score	0.510107 (rank : 32)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_HUMAN
θ value	1.06045e-08 (rank : 42)	NC score	0.501134 (rank : 35)
Query Neighborhood Hits	351	Target Neighborhood Hits	151	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_MOUSE
θ value	1.06045e-08 (rank : 43)	NC score	0.533705 (rank : 26)
Query Neighborhood Hits	351	Target Neighborhood Hits	257	Shared Neighborhood Hits	69
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PREX1_HUMAN
θ value	3.08544e-08 (rank : 44)	NC score	0.557225 (rank : 22)
Query Neighborhood Hits	351	Target Neighborhood Hits	177	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

DUET_HUMAN
θ value	5.26297e-08 (rank : 45)	NC score	0.160726 (rank : 185)
Query Neighborhood Hits	351	Target Neighborhood Hits	1220	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

SHAN1_HUMAN
θ value	1.99992e-07 (rank : 46)	NC score	0.207374 (rank : 160)
Query Neighborhood Hits	351	Target Neighborhood Hits	1041	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PDZD1_MOUSE
θ value	3.41135e-07 (rank : 47)	NC score	0.380390 (rank : 55)
Query Neighborhood Hits	351	Target Neighborhood Hits	191	Shared Neighborhood Hits	137
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

TIAM1_MOUSE
θ value	4.45536e-07 (rank : 48)	NC score	0.540782 (rank : 24)
Query Neighborhood Hits	351	Target Neighborhood Hits	205	Shared Neighborhood Hits	104
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

LAP4_HUMAN
θ value	5.81887e-07 (rank : 49)	NC score	0.230238 (rank : 150)
Query Neighborhood Hits	351	Target Neighborhood Hits	608	Shared Neighborhood Hits	156
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

TRIO_HUMAN
θ value	7.59969e-07 (rank : 50)	NC score	0.156016 (rank : 186)
Query Neighborhood Hits	351	Target Neighborhood Hits	1580	Shared Neighborhood Hits	128
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHG1_HUMAN
θ value	9.92553e-07 (rank : 51)	NC score	0.501372 (rank : 34)
Query Neighborhood Hits	351	Target Neighborhood Hits	174	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

RHPN1_MOUSE
θ value	9.92553e-07 (rank : 52)	NC score	0.292072 (rank : 107)
Query Neighborhood Hits	351	Target Neighborhood Hits	154	Shared Neighborhood Hits	119
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_HUMAN
θ value	1.29631e-06 (rank : 53)	NC score	0.272990 (rank : 125)
Query Neighborhood Hits	351	Target Neighborhood Hits	158	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

DLG2_HUMAN
θ value	2.21117e-06 (rank : 54)	NC score	0.290091 (rank : 108)
Query Neighborhood Hits	351	Target Neighborhood Hits	279	Shared Neighborhood Hits	145
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

FARP1_HUMAN
θ value	2.21117e-06 (rank : 55)	NC score	0.305091 (rank : 93)
Query Neighborhood Hits	351	Target Neighborhood Hits	241	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TIAM1_HUMAN
θ value	2.21117e-06 (rank : 56)	NC score	0.542809 (rank : 23)
Query Neighborhood Hits	351	Target Neighborhood Hits	225	Shared Neighborhood Hits	125
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PTN13_HUMAN
θ value	2.88788e-06 (rank : 57)	NC score	0.196806 (rank : 168)
Query Neighborhood Hits	351	Target Neighborhood Hits	471	Shared Neighborhood Hits	146
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

SHAN2_HUMAN
θ value	2.88788e-06 (rank : 58)	NC score	0.269844 (rank : 129)
Query Neighborhood Hits	351	Target Neighborhood Hits	346	Shared Neighborhood Hits	117
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

NHERF_MOUSE
θ value	4.92598e-06 (rank : 59)	NC score	0.360409 (rank : 58)
Query Neighborhood Hits	351	Target Neighborhood Hits	195	Shared Neighborhood Hits	137
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

SHAN2_MOUSE
θ value	6.43352e-06 (rank : 60)	NC score	0.302814 (rank : 97)
Query Neighborhood Hits	351	Target Neighborhood Hits	446	Shared Neighborhood Hits	134
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

PDZD1_HUMAN
θ value	1.09739e-05 (rank : 61)	NC score	0.367339 (rank : 57)
Query Neighborhood Hits	351	Target Neighborhood Hits	190	Shared Neighborhood Hits	142
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD3_HUMAN
θ value	1.09739e-05 (rank : 62)	NC score	0.356468 (rank : 60)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	137
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

ARHGA_HUMAN
θ value	1.43324e-05 (rank : 63)	NC score	0.433573 (rank : 45)
Query Neighborhood Hits	351	Target Neighborhood Hits	187	Shared Neighborhood Hits	67
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

LAP4_MOUSE
θ value	1.43324e-05 (rank : 64)	NC score	0.220802 (rank : 155)
Query Neighborhood Hits	351	Target Neighborhood Hits	590	Shared Neighborhood Hits	153
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

DLG2_MOUSE
θ value	1.87187e-05 (rank : 65)	NC score	0.286858 (rank : 111)
Query Neighborhood Hits	351	Target Neighborhood Hits	271	Shared Neighborhood Hits	144
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SNTG2_HUMAN
θ value	2.44474e-05 (rank : 66)	NC score	0.297049 (rank : 103)
Query Neighborhood Hits	351	Target Neighborhood Hits	191	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

RGS3_MOUSE
θ value	3.19293e-05 (rank : 67)	NC score	0.098349 (rank : 267)
Query Neighborhood Hits	351	Target Neighborhood Hits	1621	Shared Neighborhood Hits	109
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

FARP2_MOUSE
θ value	4.1701e-05 (rank : 68)	NC score	0.332660 (rank : 74)
Query Neighborhood Hits	351	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MAGI2_HUMAN
θ value	4.1701e-05 (rank : 69)	NC score	0.303325 (rank : 96)
Query Neighborhood Hits	351	Target Neighborhood Hits	373	Shared Neighborhood Hits	148
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

USH1C_HUMAN
θ value	4.1701e-05 (rank : 70)	NC score	0.356369 (rank : 61)
Query Neighborhood Hits	351	Target Neighborhood Hits	327	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

MAGI2_MOUSE
θ value	5.44631e-05 (rank : 71)	NC score	0.300786 (rank : 100)
Query Neighborhood Hits	351	Target Neighborhood Hits	370	Shared Neighborhood Hits	145
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

ZO1_MOUSE
θ value	5.44631e-05 (rank : 72)	NC score	0.253455 (rank : 136)
Query Neighborhood Hits	351	Target Neighborhood Hits	453	Shared Neighborhood Hits	143
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

FARP2_HUMAN
θ value	7.1131e-05 (rank : 73)	NC score	0.304955 (rank : 94)
Query Neighborhood Hits	351	Target Neighborhood Hits	240	Shared Neighborhood Hits	67
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD6_MOUSE
θ value	7.1131e-05 (rank : 74)	NC score	0.406340 (rank : 51)
Query Neighborhood Hits	351	Target Neighborhood Hits	282	Shared Neighborhood Hits	73
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

MCF2_HUMAN
θ value	7.1131e-05 (rank : 75)	NC score	0.452527 (rank : 42)
Query Neighborhood Hits	351	Target Neighborhood Hits	166	Shared Neighborhood Hits	77
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

RGS3_HUMAN
θ value	9.29e-05 (rank : 76)	NC score	0.103647 (rank : 260)
Query Neighborhood Hits	351	Target Neighborhood Hits	1375	Shared Neighborhood Hits	94
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

HAPIP_HUMAN
θ value	0.000121331 (rank : 77)	NC score	0.357885 (rank : 59)
Query Neighborhood Hits	351	Target Neighborhood Hits	350	Shared Neighborhood Hits	99
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PAR3L_HUMAN
θ value	0.000121331 (rank : 78)	NC score	0.307277 (rank : 89)
Query Neighborhood Hits	351	Target Neighborhood Hits	297	Shared Neighborhood Hits	127
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

FGD6_HUMAN
θ value	0.000158464 (rank : 79)	NC score	0.403252 (rank : 52)
Query Neighborhood Hits	351	Target Neighborhood Hits	237	Shared Neighborhood Hits	65
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PDZD3_MOUSE
θ value	0.00020696 (rank : 80)	NC score	0.342550 (rank : 67)
Query Neighborhood Hits	351	Target Neighborhood Hits	171	Shared Neighborhood Hits	134
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PTN13_MOUSE
θ value	0.00020696 (rank : 81)	NC score	0.191748 (rank : 173)
Query Neighborhood Hits	351	Target Neighborhood Hits	426	Shared Neighborhood Hits	149
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

WHRN_MOUSE
θ value	0.00020696 (rank : 82)	NC score	0.341646 (rank : 68)
Query Neighborhood Hits	351	Target Neighborhood Hits	412	Shared Neighborhood Hits	157
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

ARHG7_HUMAN
θ value	0.000270298 (rank : 83)	NC score	0.344234 (rank : 66)
Query Neighborhood Hits	351	Target Neighborhood Hits	347	Shared Neighborhood Hits	86
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NHERF_HUMAN
θ value	0.000270298 (rank : 84)	NC score	0.350525 (rank : 63)
Query Neighborhood Hits	351	Target Neighborhood Hits	190	Shared Neighborhood Hits	138
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	0.000270298 (rank : 85)	NC score	0.347894 (rank : 64)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	141
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

SYJ2B_HUMAN
θ value	0.000270298 (rank : 86)	NC score	0.345654 (rank : 65)
Query Neighborhood Hits	351	Target Neighborhood Hits	162	Shared Neighborhood Hits	122
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

DLG3_MOUSE
θ value	0.00035302 (rank : 87)	NC score	0.284839 (rank : 113)
Query Neighborhood Hits	351	Target Neighborhood Hits	274	Shared Neighborhood Hits	141
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

MAGI1_HUMAN
θ value	0.00035302 (rank : 88)	NC score	0.306910 (rank : 90)
Query Neighborhood Hits	351	Target Neighborhood Hits	388	Shared Neighborhood Hits	154
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	0.00035302 (rank : 89)	NC score	0.305993 (rank : 91)
Query Neighborhood Hits	351	Target Neighborhood Hits	403	Shared Neighborhood Hits	155
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

SYP2L_HUMAN
θ value	0.00035302 (rank : 90)	NC score	0.224023 (rank : 153)
Query Neighborhood Hits	351	Target Neighborhood Hits	400	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

DLG1_MOUSE
θ value	0.000461057 (rank : 91)	NC score	0.279888 (rank : 117)
Query Neighborhood Hits	351	Target Neighborhood Hits	285	Shared Neighborhood Hits	135
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

LIN7A_HUMAN
θ value	0.000461057 (rank : 92)	NC score	0.334627 (rank : 72)
Query Neighborhood Hits	351	Target Neighborhood Hits	193	Shared Neighborhood Hits	142
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	0.000461057 (rank : 93)	NC score	0.335066 (rank : 71)
Query Neighborhood Hits	351	Target Neighborhood Hits	193	Shared Neighborhood Hits	142
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

DLG1_HUMAN
θ value	0.000602161 (rank : 94)	NC score	0.280882 (rank : 116)
Query Neighborhood Hits	351	Target Neighborhood Hits	290	Shared Neighborhood Hits	139
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

LIN7B_MOUSE
θ value	0.000602161 (rank : 95)	NC score	0.332414 (rank : 75)
Query Neighborhood Hits	351	Target Neighborhood Hits	200	Shared Neighborhood Hits	140
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

PDZD2_HUMAN
θ value	0.000602161 (rank : 96)	NC score	0.288827 (rank : 109)
Query Neighborhood Hits	351	Target Neighborhood Hits	772	Shared Neighborhood Hits	159
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

WHRN_HUMAN
θ value	0.000602161 (rank : 97)	NC score	0.340572 (rank : 69)
Query Neighborhood Hits	351	Target Neighborhood Hits	325	Shared Neighborhood Hits	156
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

DLG3_HUMAN
θ value	0.000786445 (rank : 98)	NC score	0.282592 (rank : 115)
Query Neighborhood Hits	351	Target Neighborhood Hits	269	Shared Neighborhood Hits	141
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

LIN7B_HUMAN
θ value	0.000786445 (rank : 99)	NC score	0.332891 (rank : 73)
Query Neighborhood Hits	351	Target Neighborhood Hits	200	Shared Neighborhood Hits	140
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MAST1_MOUSE
θ value	0.000786445 (rank : 100)	NC score	0.054648 (rank : 421)
Query Neighborhood Hits	351	Target Neighborhood Hits	1123	Shared Neighborhood Hits	116
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SDCB1_HUMAN
θ value	0.000786445 (rank : 101)	NC score	0.243901 (rank : 144)
Query Neighborhood Hits	351	Target Neighborhood Hits	150	Shared Neighborhood Hits	127
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.000786445 (rank : 102)	NC score	0.246672 (rank : 142)
Query Neighborhood Hits	351	Target Neighborhood Hits	144	Shared Neighborhood Hits	121
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

MAST1_HUMAN
θ value	0.00102713 (rank : 103)	NC score	0.054855 (rank : 418)
Query Neighborhood Hits	351	Target Neighborhood Hits	1146	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RGS12_HUMAN
θ value	0.00102713 (rank : 104)	NC score	0.186210 (rank : 175)
Query Neighborhood Hits	351	Target Neighborhood Hits	333	Shared Neighborhood Hits	116
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SNTB2_MOUSE
θ value	0.00102713 (rank : 105)	NC score	0.276417 (rank : 121)
Query Neighborhood Hits	351	Target Neighborhood Hits	181	Shared Neighborhood Hits	121
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

USH1C_MOUSE
θ value	0.00102713 (rank : 106)	NC score	0.335846 (rank : 70)
Query Neighborhood Hits	351	Target Neighborhood Hits	557	Shared Neighborhood Hits	175
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

MCF2L_MOUSE
θ value	0.00134147 (rank : 107)	NC score	0.420510 (rank : 50)
Query Neighborhood Hits	351	Target Neighborhood Hits	255	Shared Neighborhood Hits	83
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MPDZ_MOUSE
θ value	0.00134147 (rank : 108)	NC score	0.308545 (rank : 87)
Query Neighborhood Hits	351	Target Neighborhood Hits	298	Shared Neighborhood Hits	145
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PARD3_HUMAN
θ value	0.00134147 (rank : 109)	NC score	0.298525 (rank : 101)
Query Neighborhood Hits	351	Target Neighborhood Hits	312	Shared Neighborhood Hits	146
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	0.00134147 (rank : 110)	NC score	0.297108 (rank : 102)
Query Neighborhood Hits	351	Target Neighborhood Hits	290	Shared Neighborhood Hits	142
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

SNTG1_HUMAN
θ value	0.00134147 (rank : 111)	NC score	0.286846 (rank : 112)
Query Neighborhood Hits	351	Target Neighborhood Hits	181	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

GRIP2_HUMAN
θ value	0.00175202 (rank : 112)	NC score	0.302718 (rank : 98)
Query Neighborhood Hits	351	Target Neighborhood Hits	256	Shared Neighborhood Hits	147
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LRRC7_HUMAN
θ value	0.00175202 (rank : 113)	NC score	0.127412 (rank : 209)
Query Neighborhood Hits	351	Target Neighborhood Hits	423	Shared Neighborhood Hits	98
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.00175202 (rank : 114)	NC score	0.126962 (rank : 210)
Query Neighborhood Hits	351	Target Neighborhood Hits	416	Shared Neighborhood Hits	100
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PDZD7_HUMAN
θ value	0.00175202 (rank : 115)	NC score	0.354950 (rank : 62)
Query Neighborhood Hits	351	Target Neighborhood Hits	181	Shared Neighborhood Hits	141
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

ZO1_HUMAN
θ value	0.00175202 (rank : 116)	NC score	0.244369 (rank : 143)
Query Neighborhood Hits	351	Target Neighborhood Hits	474	Shared Neighborhood Hits	141
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

GRIP1_HUMAN
θ value	0.00228821 (rank : 117)	NC score	0.296464 (rank : 105)
Query Neighborhood Hits	351	Target Neighborhood Hits	231	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

INADL_HUMAN
θ value	0.00228821 (rank : 118)	NC score	0.308208 (rank : 88)
Query Neighborhood Hits	351	Target Neighborhood Hits	260	Shared Neighborhood Hits	143
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MAST2_HUMAN
θ value	0.00228821 (rank : 119)	NC score	0.053859 (rank : 430)
Query Neighborhood Hits	351	Target Neighborhood Hits	1189	Shared Neighborhood Hits	121
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

SNTB2_HUMAN
θ value	0.00228821 (rank : 120)	NC score	0.274336 (rank : 123)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	121
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

LIN7C_HUMAN
θ value	0.00298849 (rank : 121)	NC score	0.327505 (rank : 78)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	0.00298849 (rank : 122)	NC score	0.327505 (rank : 79)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	141
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LNX1_HUMAN
θ value	0.00298849 (rank : 123)	NC score	0.267934 (rank : 130)
Query Neighborhood Hits	351	Target Neighborhood Hits	379	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MAST4_HUMAN
θ value	0.00298849 (rank : 124)	NC score	0.054167 (rank : 425)
Query Neighborhood Hits	351	Target Neighborhood Hits	1804	Shared Neighborhood Hits	141
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

RPGF6_HUMAN
θ value	0.00298849 (rank : 125)	NC score	0.210367 (rank : 159)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	131
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

INADL_MOUSE
θ value	0.00390308 (rank : 126)	NC score	0.312310 (rank : 84)
Query Neighborhood Hits	351	Target Neighborhood Hits	290	Shared Neighborhood Hits	145
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LNX1_MOUSE
θ value	0.00390308 (rank : 127)	NC score	0.270907 (rank : 127)
Query Neighborhood Hits	351	Target Neighborhood Hits	377	Shared Neighborhood Hits	137
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_MOUSE
θ value	0.00390308 (rank : 128)	NC score	0.274306 (rank : 124)
Query Neighborhood Hits	351	Target Neighborhood Hits	407	Shared Neighborhood Hits	140
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PZRN3_MOUSE
θ value	0.00390308 (rank : 129)	NC score	0.232745 (rank : 148)
Query Neighborhood Hits	351	Target Neighborhood Hits	447	Shared Neighborhood Hits	130
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SNTG1_MOUSE
θ value	0.00390308 (rank : 130)	NC score	0.284214 (rank : 114)
Query Neighborhood Hits	351	Target Neighborhood Hits	179	Shared Neighborhood Hits	129
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

PZRN3_HUMAN
θ value	0.00509761 (rank : 131)	NC score	0.230060 (rank : 151)
Query Neighborhood Hits	351	Target Neighborhood Hits	461	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

DNMBP_MOUSE
θ value	0.00665767 (rank : 132)	NC score	0.388178 (rank : 54)
Query Neighborhood Hits	351	Target Neighborhood Hits	435	Shared Neighborhood Hits	80
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRIP1_MOUSE
θ value	0.00665767 (rank : 133)	NC score	0.293995 (rank : 106)
Query Neighborhood Hits	351	Target Neighborhood Hits	241	Shared Neighborhood Hits	148
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LNX2_HUMAN
θ value	0.00665767 (rank : 134)	NC score	0.270893 (rank : 128)
Query Neighborhood Hits	351	Target Neighborhood Hits	389	Shared Neighborhood Hits	140
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

DLG4_HUMAN
θ value	0.00869519 (rank : 135)	NC score	0.277984 (rank : 120)
Query Neighborhood Hits	351	Target Neighborhood Hits	286	Shared Neighborhood Hits	139
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	0.00869519 (rank : 136)	NC score	0.278076 (rank : 119)
Query Neighborhood Hits	351	Target Neighborhood Hits	282	Shared Neighborhood Hits	141
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DNMBP_HUMAN
θ value	0.00869519 (rank : 137)	NC score	0.379601 (rank : 56)
Query Neighborhood Hits	351	Target Neighborhood Hits	413	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GOPC_HUMAN
θ value	0.00869519 (rank : 138)	NC score	0.309216 (rank : 86)
Query Neighborhood Hits	351	Target Neighborhood Hits	377	Shared Neighborhood Hits	162
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.00869519 (rank : 139)	NC score	0.310393 (rank : 85)
Query Neighborhood Hits	351	Target Neighborhood Hits	323	Shared Neighborhood Hits	158
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

MAST2_MOUSE
θ value	0.00869519 (rank : 140)	NC score	0.052403 (rank : 446)
Query Neighborhood Hits	351	Target Neighborhood Hits	1110	Shared Neighborhood Hits	120
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PSCBP_MOUSE
θ value	0.00869519 (rank : 141)	NC score	0.257758 (rank : 133)
Query Neighborhood Hits	351	Target Neighborhood Hits	118	Shared Neighborhood Hits	104
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

ZO2_MOUSE
θ value	0.00869519 (rank : 142)	NC score	0.247379 (rank : 141)
Query Neighborhood Hits	351	Target Neighborhood Hits	296	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

GOGB1_HUMAN
θ value	0.0113563 (rank : 143)	NC score	0.061199 (rank : 384)
Query Neighborhood Hits	351	Target Neighborhood Hits	2297	Shared Neighborhood Hits	127
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

NEB1_HUMAN
θ value	0.0113563 (rank : 144)	NC score	0.201204 (rank : 164)
Query Neighborhood Hits	351	Target Neighborhood Hits	829	Shared Neighborhood Hits	163
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

MAST3_HUMAN
θ value	0.0148317 (rank : 145)	NC score	0.051335 (rank : 457)
Query Neighborhood Hits	351	Target Neighborhood Hits	1128	Shared Neighborhood Hits	116
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MPDZ_HUMAN
θ value	0.0148317 (rank : 146)	NC score	0.303897 (rank : 95)
Query Neighborhood Hits	351	Target Neighborhood Hits	261	Shared Neighborhood Hits	149
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

ZO2_HUMAN
θ value	0.0148317 (rank : 147)	NC score	0.249513 (rank : 139)
Query Neighborhood Hits	351	Target Neighborhood Hits	289	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ARHG6_HUMAN
θ value	0.0193708 (rank : 148)	NC score	0.305813 (rank : 92)
Query Neighborhood Hits	351	Target Neighborhood Hits	376	Shared Neighborhood Hits	72
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NHRF2_MOUSE
θ value	0.0193708 (rank : 149)	NC score	0.328160 (rank : 77)
Query Neighborhood Hits	351	Target Neighborhood Hits	194	Shared Neighborhood Hits	138
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDLI5_MOUSE
θ value	0.0193708 (rank : 150)	NC score	0.114899 (rank : 232)
Query Neighborhood Hits	351	Target Neighborhood Hits	287	Shared Neighborhood Hits	102
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

SNTG2_MOUSE
θ value	0.0193708 (rank : 151)	NC score	0.271085 (rank : 126)
Query Neighborhood Hits	351	Target Neighborhood Hits	176	Shared Neighborhood Hits	125
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

APBA1_HUMAN
θ value	0.0252991 (rank : 152)	NC score	0.212307 (rank : 157)
Query Neighborhood Hits	351	Target Neighborhood Hits	325	Shared Neighborhood Hits	124
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

LDB3_HUMAN
θ value	0.0252991 (rank : 153)	NC score	0.114382 (rank : 234)
Query Neighborhood Hits	351	Target Neighborhood Hits	497	Shared Neighborhood Hits	97
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDZ11_MOUSE
θ value	0.0252991 (rank : 154)	NC score	0.327494 (rank : 80)
Query Neighborhood Hits	351	Target Neighborhood Hits	154	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

RPGF2_HUMAN
θ value	0.0252991 (rank : 155)	NC score	0.187678 (rank : 174)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SYP2L_MOUSE
θ value	0.0252991 (rank : 156)	NC score	0.179085 (rank : 178)
Query Neighborhood Hits	351	Target Neighborhood Hits	289	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

FGD5_MOUSE
θ value	0.0330416 (rank : 157)	NC score	0.275147 (rank : 122)
Query Neighborhood Hits	351	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

NBR1_HUMAN
θ value	0.0330416 (rank : 158)	NC score	0.054050 (rank : 428)
Query Neighborhood Hits	351	Target Neighborhood Hits	105	Shared Neighborhood Hits	12
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

PDZ11_HUMAN
θ value	0.0330416 (rank : 159)	NC score	0.328838 (rank : 76)
Query Neighborhood Hits	351	Target Neighborhood Hits	160	Shared Neighborhood Hits	123
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

APBA2_HUMAN
θ value	0.0431538 (rank : 160)	NC score	0.206039 (rank : 161)
Query Neighborhood Hits	351	Target Neighborhood Hits	220	Shared Neighborhood Hits	119
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.0431538 (rank : 161)	NC score	0.206029 (rank : 162)
Query Neighborhood Hits	351	Target Neighborhood Hits	219	Shared Neighborhood Hits	122
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

EVPL_HUMAN
θ value	0.0431538 (rank : 162)	NC score	0.075417 (rank : 314)
Query Neighborhood Hits	351	Target Neighborhood Hits	895	Shared Neighborhood Hits	83
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

FGD5_HUMAN
θ value	0.0431538 (rank : 163)	NC score	0.296991 (rank : 104)
Query Neighborhood Hits	351	Target Neighborhood Hits	235	Shared Neighborhood Hits	48
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

RRBP1_MOUSE
θ value	0.0431538 (rank : 164)	NC score	0.048897 (rank : 476)
Query Neighborhood Hits	351	Target Neighborhood Hits	1650	Shared Neighborhood Hits	100
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TX1B3_HUMAN
θ value	0.0431538 (rank : 165)	NC score	0.316167 (rank : 81)
Query Neighborhood Hits	351	Target Neighborhood Hits	161	Shared Neighborhood Hits	126
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.0431538 (rank : 166)	NC score	0.314968 (rank : 82)
Query Neighborhood Hits	351	Target Neighborhood Hits	158	Shared Neighborhood Hits	124
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

EVPL_MOUSE
θ value	0.0563607 (rank : 167)	NC score	0.068004 (rank : 341)
Query Neighborhood Hits	351	Target Neighborhood Hits	952	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

GRASP_HUMAN
θ value	0.0563607 (rank : 168)	NC score	0.256852 (rank : 134)
Query Neighborhood Hits	351	Target Neighborhood Hits	147	Shared Neighborhood Hits	109
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HTRA3_HUMAN
θ value	0.0563607 (rank : 169)	NC score	0.085006 (rank : 297)
Query Neighborhood Hits	351	Target Neighborhood Hits	152	Shared Neighborhood Hits	56
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

PDLI5_HUMAN
θ value	0.0563607 (rank : 170)	NC score	0.116966 (rank : 225)
Query Neighborhood Hits	351	Target Neighborhood Hits	322	Shared Neighborhood Hits	103
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

GOGA3_MOUSE
θ value	0.0736092 (rank : 171)	NC score	0.064724 (rank : 361)
Query Neighborhood Hits	351	Target Neighborhood Hits	1437	Shared Neighborhood Hits	108
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

PDZD8_HUMAN
θ value	0.0736092 (rank : 172)	NC score	0.130443 (rank : 206)
Query Neighborhood Hits	351	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SNTA1_HUMAN
θ value	0.0736092 (rank : 173)	NC score	0.258609 (rank : 132)
Query Neighborhood Hits	351	Target Neighborhood Hits	186	Shared Neighborhood Hits	126
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

K1543_MOUSE
θ value	0.0961366 (rank : 174)	NC score	0.045231 (rank : 490)
Query Neighborhood Hits	351	Target Neighborhood Hits	497	Shared Neighborhood Hits	44
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MPP3_MOUSE
θ value	0.0961366 (rank : 175)	NC score	0.163066 (rank : 183)
Query Neighborhood Hits	351	Target Neighborhood Hits	165	Shared Neighborhood Hits	103
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

NEB2_HUMAN
θ value	0.0961366 (rank : 176)	NC score	0.193430 (rank : 169)
Query Neighborhood Hits	351	Target Neighborhood Hits	883	Shared Neighborhood Hits	161
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	0.0961366 (rank : 177)	NC score	0.192153 (rank : 170)
Query Neighborhood Hits	351	Target Neighborhood Hits	889	Shared Neighborhood Hits	163
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PSCBP_HUMAN
θ value	0.0961366 (rank : 178)	NC score	0.236023 (rank : 147)
Query Neighborhood Hits	351	Target Neighborhood Hits	123	Shared Neighborhood Hits	101
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PZRN4_HUMAN
θ value	0.0961366 (rank : 179)	NC score	0.231037 (rank : 149)
Query Neighborhood Hits	351	Target Neighborhood Hits	438	Shared Neighborhood Hits	129
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

ZO3_HUMAN
θ value	0.0961366 (rank : 180)	NC score	0.254494 (rank : 135)
Query Neighborhood Hits	351	Target Neighborhood Hits	219	Shared Neighborhood Hits	135
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

APBA3_MOUSE
θ value	0.125558 (rank : 181)	NC score	0.199490 (rank : 165)
Query Neighborhood Hits	351	Target Neighborhood Hits	174	Shared Neighborhood Hits	111
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

GRASP_MOUSE
θ value	0.125558 (rank : 182)	NC score	0.251436 (rank : 138)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	109
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HTRA3_MOUSE
θ value	0.125558 (rank : 183)	NC score	0.085301 (rank : 296)
Query Neighborhood Hits	351	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

MPP3_HUMAN
θ value	0.125558 (rank : 184)	NC score	0.160882 (rank : 184)
Query Neighborhood Hits	351	Target Neighborhood Hits	171	Shared Neighborhood Hits	103
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

SNTA1_MOUSE
θ value	0.125558 (rank : 185)	NC score	0.252772 (rank : 137)
Query Neighborhood Hits	351	Target Neighborhood Hits	170	Shared Neighborhood Hits	123
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

CP250_MOUSE
θ value	0.163984 (rank : 186)	NC score	0.067007 (rank : 343)
Query Neighborhood Hits	351	Target Neighborhood Hits	1583	Shared Neighborhood Hits	104
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

SNTB1_MOUSE
θ value	0.163984 (rank : 187)	NC score	0.238035 (rank : 145)
Query Neighborhood Hits	351	Target Neighborhood Hits	160	Shared Neighborhood Hits	113
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

CP250_HUMAN
θ value	0.21417 (rank : 188)	NC score	0.068398 (rank : 338)
Query Neighborhood Hits	351	Target Neighborhood Hits	1805	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CROCC_MOUSE
θ value	0.21417 (rank : 189)	NC score	0.057226 (rank : 405)
Query Neighborhood Hits	351	Target Neighborhood Hits	1460	Shared Neighborhood Hits	106
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

LDB3_MOUSE
θ value	0.21417 (rank : 190)	NC score	0.113420 (rank : 236)
Query Neighborhood Hits	351	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

RHPN2_MOUSE
θ value	0.21417 (rank : 191)	NC score	0.111197 (rank : 249)
Query Neighborhood Hits	351	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

SNTB1_HUMAN
θ value	0.21417 (rank : 192)	NC score	0.237651 (rank : 146)
Query Neighborhood Hits	351	Target Neighborhood Hits	157	Shared Neighborhood Hits	113
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SYNP2_MOUSE
θ value	0.21417 (rank : 193)	NC score	0.171246 (rank : 181)
Query Neighborhood Hits	351	Target Neighborhood Hits	252	Shared Neighborhood Hits	107
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

ZO3_MOUSE
θ value	0.21417 (rank : 194)	NC score	0.259305 (rank : 131)
Query Neighborhood Hits	351	Target Neighborhood Hits	224	Shared Neighborhood Hits	138
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ARHG6_MOUSE
θ value	0.279714 (rank : 195)	NC score	0.287221 (rank : 110)
Query Neighborhood Hits	351	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CP238_MOUSE
θ value	0.279714 (rank : 196)	NC score	0.010393 (rank : 555)
Query Neighborhood Hits	351	Target Neighborhood Hits	112	Shared Neighborhood Hits	6
SwissProt Accessions	P56655	Gene names	Cyp2c38
Domain Architecture
Description	Cytochrome P450 2C38 (EC 1.14.14.1) (CYPIIC38).

FMNL_MOUSE
θ value	0.279714 (rank : 197)	NC score	0.031097 (rank : 515)
Query Neighborhood Hits	351	Target Neighborhood Hits	428	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

PCNT_MOUSE
θ value	0.279714 (rank : 198)	NC score	0.065202 (rank : 355)
Query Neighborhood Hits	351	Target Neighborhood Hits	1207	Shared Neighborhood Hits	103
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

SOS2_HUMAN
θ value	0.279714 (rank : 199)	NC score	0.143154 (rank : 195)
Query Neighborhood Hits	351	Target Neighborhood Hits	193	Shared Neighborhood Hits	46
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

MYH11_HUMAN
θ value	0.365318 (rank : 200)	NC score	0.040057 (rank : 499)
Query Neighborhood Hits	351	Target Neighborhood Hits	1806	Shared Neighborhood Hits	115
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PDLI2_MOUSE
θ value	0.365318 (rank : 201)	NC score	0.192005 (rank : 172)
Query Neighborhood Hits	351	Target Neighborhood Hits	220	Shared Neighborhood Hits	110
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

TPM3_HUMAN
θ value	0.365318 (rank : 202)	NC score	0.049853 (rank : 472)
Query Neighborhood Hits	351	Target Neighborhood Hits	689	Shared Neighborhood Hits	67
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
θ value	0.365318 (rank : 203)	NC score	0.049481 (rank : 474)
Query Neighborhood Hits	351	Target Neighborhood Hits	676	Shared Neighborhood Hits	67
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

APBA3_HUMAN
θ value	0.47712 (rank : 204)	NC score	0.204319 (rank : 163)
Query Neighborhood Hits	351	Target Neighborhood Hits	201	Shared Neighborhood Hits	116
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MPP10_MOUSE
θ value	0.47712 (rank : 205)	NC score	0.027723 (rank : 521)
Query Neighborhood Hits	351	Target Neighborhood Hits	251	Shared Neighborhood Hits	27
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MYH11_MOUSE
θ value	0.47712 (rank : 206)	NC score	0.039845 (rank : 500)
Query Neighborhood Hits	351	Target Neighborhood Hits	1777	Shared Neighborhood Hits	112
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

SI1L2_HUMAN
θ value	0.47712 (rank : 207)	NC score	0.059812 (rank : 389)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	0.47712 (rank : 208)	NC score	0.058346 (rank : 396)
Query Neighborhood Hits	351	Target Neighborhood Hits	124	Shared Neighborhood Hits	56
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

LAP2_HUMAN
θ value	0.62314 (rank : 209)	NC score	0.107241 (rank : 255)
Query Neighborhood Hits	351	Target Neighborhood Hits	499	Shared Neighborhood Hits	96
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	0.62314 (rank : 210)	NC score	0.103569 (rank : 261)
Query Neighborhood Hits	351	Target Neighborhood Hits	482	Shared Neighborhood Hits	96
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

NCOAT_HUMAN
θ value	0.62314 (rank : 211)	NC score	0.039398 (rank : 501)
Query Neighborhood Hits	351	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0	Gene names	MGEA5, HEXC, KIAA0679, MEA5
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

PDLI2_HUMAN
θ value	0.62314 (rank : 212)	NC score	0.192090 (rank : 171)
Query Neighborhood Hits	351	Target Neighborhood Hits	245	Shared Neighborhood Hits	115
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PTN3_HUMAN
θ value	0.62314 (rank : 213)	NC score	0.086510 (rank : 294)
Query Neighborhood Hits	351	Target Neighborhood Hits	258	Shared Neighborhood Hits	109
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PEPL_MOUSE
θ value	0.813845 (rank : 214)	NC score	0.059197 (rank : 391)
Query Neighborhood Hits	351	Target Neighborhood Hits	1105	Shared Neighborhood Hits	93
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

RL21_MOUSE
θ value	0.813845 (rank : 215)	NC score	0.047859 (rank : 483)
Query Neighborhood Hits	351	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	O09167	Gene names	Rpl21
Domain Architecture
Description	60S ribosomal protein L21.

TOX_HUMAN
θ value	0.813845 (rank : 216)	NC score	0.020511 (rank : 533)
Query Neighborhood Hits	351	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	O94900, Q96AV5	Gene names	TOX, KIAA0808
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

ACK1_HUMAN
θ value	1.06291 (rank : 217)	NC score	0.004738 (rank : 573)
Query Neighborhood Hits	351	Target Neighborhood Hits	1140	Shared Neighborhood Hits	34
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

AKAP9_HUMAN
θ value	1.06291 (rank : 218)	NC score	0.055337 (rank : 414)
Query Neighborhood Hits	351	Target Neighborhood Hits	1710	Shared Neighborhood Hits	106
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ARX_MOUSE
θ value	1.06291 (rank : 219)	NC score	0.000451 (rank : 579)
Query Neighborhood Hits	351	Target Neighborhood Hits	398	Shared Neighborhood Hits	10
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

GRIPE_HUMAN
θ value	1.06291 (rank : 220)	NC score	0.030371 (rank : 518)
Query Neighborhood Hits	351	Target Neighborhood Hits	69	Shared Neighborhood Hits	8
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

LAP2B_HUMAN
θ value	1.06291 (rank : 221)	NC score	0.021481 (rank : 530)
Query Neighborhood Hits	351	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	P42167, Q14861	Gene names	TMPO, LAP2
Domain Architecture
Description	Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Contains: Thymopoietin (TP) (Splenin); Thymopentin (TP5)].

LMO7_HUMAN
θ value	1.06291 (rank : 222)	NC score	0.120395 (rank : 216)
Query Neighborhood Hits	351	Target Neighborhood Hits	507	Shared Neighborhood Hits	94
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MDC1_MOUSE
θ value	1.06291 (rank : 223)	NC score	0.030552 (rank : 516)
Query Neighborhood Hits	351	Target Neighborhood Hits	998	Shared Neighborhood Hits	56
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MY18A_MOUSE
θ value	1.06291 (rank : 224)	NC score	0.080669 (rank : 301)
Query Neighborhood Hits	351	Target Neighborhood Hits	1989	Shared Neighborhood Hits	195
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TPM1_HUMAN
θ value	1.06291 (rank : 225)	NC score	0.048548 (rank : 480)
Query Neighborhood Hits	351	Target Neighborhood Hits	716	Shared Neighborhood Hits	72
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	1.06291 (rank : 226)	NC score	0.048611 (rank : 479)
Query Neighborhood Hits	351	Target Neighborhood Hits	729	Shared Neighborhood Hits	74
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

BRD4_MOUSE
θ value	1.38821 (rank : 227)	NC score	0.034532 (rank : 510)
Query Neighborhood Hits	351	Target Neighborhood Hits	845	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CF060_HUMAN
θ value	1.38821 (rank : 228)	NC score	0.049634 (rank : 473)
Query Neighborhood Hits	351	Target Neighborhood Hits	1270	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

GTSE1_MOUSE
θ value	1.38821 (rank : 229)	NC score	0.026471 (rank : 523)
Query Neighborhood Hits	351	Target Neighborhood Hits	245	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

IKBL_HUMAN
θ value	1.38821 (rank : 230)	NC score	0.024876 (rank : 525)
Query Neighborhood Hits	351	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

MYO10_HUMAN
θ value	1.38821 (rank : 231)	NC score	0.032485 (rank : 513)
Query Neighborhood Hits	351	Target Neighborhood Hits	920	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PAR14_MOUSE
θ value	1.38821 (rank : 232)	NC score	0.011812 (rank : 551)
Query Neighborhood Hits	351	Target Neighborhood Hits	113	Shared Neighborhood Hits	11
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

RL21_HUMAN
θ value	1.38821 (rank : 233)	NC score	0.042459 (rank : 496)
Query Neighborhood Hits	351	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P46778, Q16699	Gene names	RPL21
Domain Architecture
Description	60S ribosomal protein L21.

TULP3_MOUSE
θ value	1.38821 (rank : 234)	NC score	0.011364 (rank : 552)
Query Neighborhood Hits	351	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	O88413	Gene names	Tulp3
Domain Architecture
Description	Tubby-related protein 3 (Tubby-like protein 3).

CBL_MOUSE
θ value	1.81305 (rank : 235)	NC score	0.016613 (rank : 539)
Query Neighborhood Hits	351	Target Neighborhood Hits	426	Shared Neighborhood Hits	26
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CCD46_MOUSE
θ value	1.81305 (rank : 236)	NC score	0.055363 (rank : 413)
Query Neighborhood Hits	351	Target Neighborhood Hits	1405	Shared Neighborhood Hits	110
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CP2C8_HUMAN
θ value	1.81305 (rank : 237)	NC score	0.005373 (rank : 572)
Query Neighborhood Hits	351	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	P10632	Gene names	CYP2C8
Domain Architecture
Description	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase).

GIPC2_HUMAN
θ value	1.81305 (rank : 238)	NC score	0.092527 (rank : 276)
Query Neighborhood Hits	351	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GOGA4_HUMAN
θ value	1.81305 (rank : 239)	NC score	0.055926 (rank : 410)
Query Neighborhood Hits	351	Target Neighborhood Hits	2034	Shared Neighborhood Hits	121
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

HOOK3_MOUSE
θ value	1.81305 (rank : 240)	NC score	0.054745 (rank : 420)
Query Neighborhood Hits	351	Target Neighborhood Hits	1007	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

AR13B_HUMAN
θ value	2.36792 (rank : 241)	NC score	0.020348 (rank : 534)
Query Neighborhood Hits	351	Target Neighborhood Hits	528	Shared Neighborhood Hits	48
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

F107B_HUMAN
θ value	2.36792 (rank : 242)	NC score	0.068493 (rank : 334)
Query Neighborhood Hits	351	Target Neighborhood Hits	120	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H098	Gene names	FAM107B, C10orf45
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

GIPC1_HUMAN
θ value	2.36792 (rank : 243)	NC score	0.101057 (rank : 265)
Query Neighborhood Hits	351	Target Neighborhood Hits	91	Shared Neighborhood Hits	69
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

HNF3G_MOUSE
θ value	2.36792 (rank : 244)	NC score	0.002053 (rank : 576)
Query Neighborhood Hits	351	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	P35584	Gene names	Foxa3, Hnf3g, Tcf-3g, Tcf3g
Domain Architecture
Description	Hepatocyte nuclear factor 3-gamma (HNF-3G) (Forkhead box protein A3).

HOOK3_HUMAN
θ value	2.36792 (rank : 245)	NC score	0.053503 (rank : 433)
Query Neighborhood Hits	351	Target Neighborhood Hits	1070	Shared Neighborhood Hits	89
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

K1C14_MOUSE
θ value	2.36792 (rank : 246)	NC score	0.013505 (rank : 549)
Query Neighborhood Hits	351	Target Neighborhood Hits	501	Shared Neighborhood Hits	60
SwissProt Accessions	Q61781, Q91VQ4	Gene names	Krt14, Krt1-14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

MPP4_HUMAN
θ value	2.36792 (rank : 247)	NC score	0.166006 (rank : 182)
Query Neighborhood Hits	351	Target Neighborhood Hits	205	Shared Neighborhood Hits	109
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MY18A_HUMAN
θ value	2.36792 (rank : 248)	NC score	0.077959 (rank : 308)
Query Neighborhood Hits	351	Target Neighborhood Hits	1929	Shared Neighborhood Hits	195
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NBR1_MOUSE
θ value	2.36792 (rank : 249)	NC score	0.039259 (rank : 502)
Query Neighborhood Hits	351	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

RAD50_HUMAN
θ value	2.36792 (rank : 250)	NC score	0.056678 (rank : 408)
Query Neighborhood Hits	351	Target Neighborhood Hits	1317	Shared Neighborhood Hits	95
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SDCB2_MOUSE
θ value	2.36792 (rank : 251)	NC score	0.180585 (rank : 177)
Query Neighborhood Hits	351	Target Neighborhood Hits	118	Shared Neighborhood Hits	101
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SENP3_HUMAN
θ value	2.36792 (rank : 252)	NC score	0.023544 (rank : 526)
Query Neighborhood Hits	351	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4L4, Q96PS4, Q9Y3W9	Gene names	SENP3, SSP3, SUSP3
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3).

TAD3L_HUMAN
θ value	2.36792 (rank : 253)	NC score	0.028651 (rank : 519)
Query Neighborhood Hits	351	Target Neighborhood Hits	189	Shared Neighborhood Hits	30
SwissProt Accessions	O75528, Q9UFS2	Gene names	TADA3L, ADA3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (hADA3).

TAD3L_MOUSE
θ value	2.36792 (rank : 254)	NC score	0.028332 (rank : 520)
Query Neighborhood Hits	351	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R0L9, Q8CIH4, Q8K289, Q8R5E3, Q9CTJ0	Gene names	Tada3l, Ada3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (mADA3).

TARA_MOUSE
θ value	2.36792 (rank : 255)	NC score	0.048977 (rank : 475)
Query Neighborhood Hits	351	Target Neighborhood Hits	1133	Shared Neighborhood Hits	88
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TOX_MOUSE
θ value	2.36792 (rank : 256)	NC score	0.016834 (rank : 538)
Query Neighborhood Hits	351	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

DIAP1_HUMAN
θ value	3.0926 (rank : 257)	NC score	0.025156 (rank : 524)
Query Neighborhood Hits	351	Target Neighborhood Hits	784	Shared Neighborhood Hits	71
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

F107B_MOUSE
θ value	3.0926 (rank : 258)	NC score	0.065231 (rank : 354)
Query Neighborhood Hits	351	Target Neighborhood Hits	126	Shared Neighborhood Hits	29
SwissProt Accessions	Q3TGF2	Gene names	Fam107b
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

GIPC1_MOUSE
θ value	3.0926 (rank : 259)	NC score	0.103909 (rank : 259)
Query Neighborhood Hits	351	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC3_HUMAN
θ value	3.0926 (rank : 260)	NC score	0.066276 (rank : 348)
Query Neighborhood Hits	351	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	3.0926 (rank : 261)	NC score	0.065370 (rank : 353)
Query Neighborhood Hits	351	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GOGA3_HUMAN
θ value	3.0926 (rank : 262)	NC score	0.054305 (rank : 423)
Query Neighborhood Hits	351	Target Neighborhood Hits	1317	Shared Neighborhood Hits	108
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA4_MOUSE
θ value	3.0926 (rank : 263)	NC score	0.051296 (rank : 458)
Query Neighborhood Hits	351	Target Neighborhood Hits	1939	Shared Neighborhood Hits	112
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SMC2_MOUSE
θ value	3.0926 (rank : 264)	NC score	0.041739 (rank : 498)
Query Neighborhood Hits	351	Target Neighborhood Hits	1131	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SYNE2_HUMAN
θ value	3.0926 (rank : 265)	NC score	0.046633 (rank : 487)
Query Neighborhood Hits	351	Target Neighborhood Hits	1323	Shared Neighborhood Hits	104
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

SYNP2_HUMAN
θ value	3.0926 (rank : 266)	NC score	0.138367 (rank : 200)
Query Neighborhood Hits	351	Target Neighborhood Hits	323	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

TRI32_MOUSE
θ value	3.0926 (rank : 267)	NC score	0.010600 (rank : 554)
Query Neighborhood Hits	351	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

ACD_MOUSE
θ value	4.03905 (rank : 268)	NC score	0.015469 (rank : 544)
Query Neighborhood Hits	351	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q5EE38, Q3TBB1, Q3TUR7, Q3UKL6, Q3V3Y1, Q99KF8	Gene names	Acd
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein.

ANR47_HUMAN
θ value	4.03905 (rank : 269)	NC score	0.010150 (rank : 558)
Query Neighborhood Hits	351	Target Neighborhood Hits	369	Shared Neighborhood Hits	15
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

APBB1_MOUSE
θ value	4.03905 (rank : 270)	NC score	0.009192 (rank : 560)
Query Neighborhood Hits	351	Target Neighborhood Hits	75	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

BRD4_HUMAN
θ value	4.03905 (rank : 271)	NC score	0.030385 (rank : 517)
Query Neighborhood Hits	351	Target Neighborhood Hits	851	Shared Neighborhood Hits	64
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CENPQ_HUMAN
θ value	4.03905 (rank : 272)	NC score	0.034526 (rank : 511)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	28
SwissProt Accessions	Q7L2Z9, Q6IN61, Q9NVS5	Gene names	CENPQ, C6orf139
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

CK5P2_HUMAN
θ value	4.03905 (rank : 273)	NC score	0.054812 (rank : 419)
Query Neighborhood Hits	351	Target Neighborhood Hits	1433	Shared Neighborhood Hits	107
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CLCA_MOUSE
θ value	4.03905 (rank : 274)	NC score	0.023508 (rank : 527)
Query Neighborhood Hits	351	Target Neighborhood Hits	106	Shared Neighborhood Hits	21
SwissProt Accessions	O08585	Gene names	Clta
Domain Architecture
Description	Clathrin light chain A (Lca).

CTGE5_MOUSE
θ value	4.03905 (rank : 275)	NC score	0.036719 (rank : 506)
Query Neighborhood Hits	351	Target Neighborhood Hits	928	Shared Neighborhood Hits	84
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

EZRI_HUMAN
θ value	4.03905 (rank : 276)	NC score	0.048896 (rank : 477)
Query Neighborhood Hits	351	Target Neighborhood Hits	663	Shared Neighborhood Hits	78
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

GBP2_HUMAN
θ value	4.03905 (rank : 277)	NC score	0.023047 (rank : 528)
Query Neighborhood Hits	351	Target Neighborhood Hits	349	Shared Neighborhood Hits	48
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

MYH10_HUMAN
θ value	4.03905 (rank : 278)	NC score	0.034910 (rank : 508)
Query Neighborhood Hits	351	Target Neighborhood Hits	1620	Shared Neighborhood Hits	107
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH9_HUMAN
θ value	4.03905 (rank : 279)	NC score	0.039174 (rank : 503)
Query Neighborhood Hits	351	Target Neighborhood Hits	1762	Shared Neighborhood Hits	113
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NASP_HUMAN
θ value	4.03905 (rank : 280)	NC score	0.020667 (rank : 531)
Query Neighborhood Hits	351	Target Neighborhood Hits	709	Shared Neighborhood Hits	55
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

OPHN1_MOUSE
θ value	4.03905 (rank : 281)	NC score	0.005396 (rank : 571)
Query Neighborhood Hits	351	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OSBP1_HUMAN
θ value	4.03905 (rank : 282)	NC score	0.008107 (rank : 563)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	20
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

RAE1_HUMAN
θ value	4.03905 (rank : 283)	NC score	0.021501 (rank : 529)
Query Neighborhood Hits	351	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	P24386, O43732	Gene names	CHM, REP1, TCD
Domain Architecture
Description	Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein) (TCD protein).

SVIL_MOUSE
θ value	4.03905 (rank : 284)	NC score	0.015066 (rank : 546)
Query Neighborhood Hits	351	Target Neighborhood Hits	439	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TARA_HUMAN
θ value	4.03905 (rank : 285)	NC score	0.048440 (rank : 481)
Query Neighborhood Hits	351	Target Neighborhood Hits	1626	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TNNT2_MOUSE
θ value	4.03905 (rank : 286)	NC score	0.037515 (rank : 505)
Query Neighborhood Hits	351	Target Neighborhood Hits	395	Shared Neighborhood Hits	51
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TRIM6_MOUSE
θ value	4.03905 (rank : 287)	NC score	0.010360 (rank : 556)
Query Neighborhood Hits	351	Target Neighborhood Hits	451	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

AFAD_HUMAN
θ value	5.27518 (rank : 288)	NC score	0.197988 (rank : 166)
Query Neighborhood Hits	351	Target Neighborhood Hits	689	Shared Neighborhood Hits	164
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

CE152_HUMAN
θ value	5.27518 (rank : 289)	NC score	0.056165 (rank : 409)
Query Neighborhood Hits	351	Target Neighborhood Hits	976	Shared Neighborhood Hits	83
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CF152_HUMAN
θ value	5.27518 (rank : 290)	NC score	0.046913 (rank : 485)
Query Neighborhood Hits	351	Target Neighborhood Hits	704	Shared Neighborhood Hits	81
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CP239_MOUSE
θ value	5.27518 (rank : 291)	NC score	0.005796 (rank : 568)
Query Neighborhood Hits	351	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	P56656	Gene names	Cyp2c39
Domain Architecture
Description	Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39).

CP2AC_MOUSE
θ value	5.27518 (rank : 292)	NC score	0.004031 (rank : 574)
Query Neighborhood Hits	351	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	P56593	Gene names	Cyp2a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7- alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase).

CTRO_MOUSE
θ value	5.27518 (rank : 293)	NC score	0.034896 (rank : 509)
Query Neighborhood Hits	351	Target Neighborhood Hits	2344	Shared Neighborhood Hits	116
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DESP_HUMAN
θ value	5.27518 (rank : 294)	NC score	0.051752 (rank : 452)
Query Neighborhood Hits	351	Target Neighborhood Hits	1470	Shared Neighborhood Hits	100
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DLG5_HUMAN
θ value	5.27518 (rank : 295)	NC score	0.197659 (rank : 167)
Query Neighborhood Hits	351	Target Neighborhood Hits	1088	Shared Neighborhood Hits	196
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ELF1_MOUSE
θ value	5.27518 (rank : 296)	NC score	0.014525 (rank : 547)
Query Neighborhood Hits	351	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

GCC2_HUMAN
θ value	5.27518 (rank : 297)	NC score	0.044300 (rank : 492)
Query Neighborhood Hits	351	Target Neighborhood Hits	1558	Shared Neighborhood Hits	100
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GIPC2_MOUSE
θ value	5.27518 (rank : 298)	NC score	0.062813 (rank : 371)
Query Neighborhood Hits	351	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GP156_HUMAN
θ value	5.27518 (rank : 299)	NC score	0.011300 (rank : 553)
Query Neighborhood Hits	351	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

HTRA4_HUMAN
θ value	5.27518 (rank : 300)	NC score	0.043343 (rank : 493)
Query Neighborhood Hits	351	Target Neighborhood Hits	119	Shared Neighborhood Hits	38
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

IRAK1_HUMAN
θ value	5.27518 (rank : 301)	NC score	0.001491 (rank : 578)
Query Neighborhood Hits	351	Target Neighborhood Hits	820	Shared Neighborhood Hits	19
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

LRFN4_MOUSE
θ value	5.27518 (rank : 302)	NC score	0.010240 (rank : 557)
Query Neighborhood Hits	351	Target Neighborhood Hits	442	Shared Neighborhood Hits	11
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

MAP9_MOUSE
θ value	5.27518 (rank : 303)	NC score	0.046339 (rank : 488)
Query Neighborhood Hits	351	Target Neighborhood Hits	529	Shared Neighborhood Hits	59
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MUCDL_HUMAN
θ value	5.27518 (rank : 304)	NC score	0.016553 (rank : 541)
Query Neighborhood Hits	351	Target Neighborhood Hits	777	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NCOAT_MOUSE
θ value	5.27518 (rank : 305)	NC score	0.020267 (rank : 535)
Query Neighborhood Hits	351	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQQ9, Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7	Gene names	Mgea5, Hexc, Kiaa0679
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

NUMA1_HUMAN
θ value	5.27518 (rank : 306)	NC score	0.054093 (rank : 427)
Query Neighborhood Hits	351	Target Neighborhood Hits	1523	Shared Neighborhood Hits	115
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PLEC1_HUMAN
θ value	5.27518 (rank : 307)	NC score	0.042579 (rank : 495)
Query Neighborhood Hits	351	Target Neighborhood Hits	1326	Shared Neighborhood Hits	99
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

RANB3_MOUSE
θ value	5.27518 (rank : 308)	NC score	0.013190 (rank : 550)
Query Neighborhood Hits	351	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CT10, Q3TIS4, Q3U2G4, Q3UYG7	Gene names	Ranbp3
Domain Architecture	No domain graphic available
Description	Ran-binding protein 3 (RanBP3).

RBP24_HUMAN
θ value	5.27518 (rank : 309)	NC score	0.044383 (rank : 491)
Query Neighborhood Hits	351	Target Neighborhood Hits	1559	Shared Neighborhood Hits	100
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

S6OS1_HUMAN
θ value	5.27518 (rank : 310)	NC score	0.016611 (rank : 540)
Query Neighborhood Hits	351	Target Neighborhood Hits	134	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N1H7	Gene names	SIX6OS1, C14orf39
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

SDCB2_HUMAN
θ value	5.27518 (rank : 311)	NC score	0.174140 (rank : 180)
Query Neighborhood Hits	351	Target Neighborhood Hits	121	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TM1L1_HUMAN
θ value	5.27518 (rank : 312)	NC score	0.007553 (rank : 564)
Query Neighborhood Hits	351	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	O75674	Gene names	TOM1L1, SRCASM
Domain Architecture
Description	TOM1-like 1 protein (Target of myb-like 1 protein) (Src-activating and signaling molecule protein).

TRI32_HUMAN
θ value	5.27518 (rank : 313)	NC score	0.009394 (rank : 559)
Query Neighborhood Hits	351	Target Neighborhood Hits	264	Shared Neighborhood Hits	23
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

APC_MOUSE
θ value	6.88961 (rank : 314)	NC score	0.017102 (rank : 536)
Query Neighborhood Hits	351	Target Neighborhood Hits	441	Shared Neighborhood Hits	50
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

CBP_HUMAN
θ value	6.88961 (rank : 315)	NC score	0.016971 (rank : 537)
Query Neighborhood Hits	351	Target Neighborhood Hits	941	Shared Neighborhood Hits	40
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CCNT2_HUMAN
θ value	6.88961 (rank : 316)	NC score	0.006245 (rank : 567)
Query Neighborhood Hits	351	Target Neighborhood Hits	84	Shared Neighborhood Hits	6
SwissProt Accessions	O60583, O60582, Q5I1Y0	Gene names	CCNT2
Domain Architecture
Description	Cyclin-T2 (CycT2).

CENPE_HUMAN
θ value	6.88961 (rank : 317)	NC score	0.043221 (rank : 494)
Query Neighborhood Hits	351	Target Neighborhood Hits	2060	Shared Neighborhood Hits	119
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CTRO_HUMAN
θ value	6.88961 (rank : 318)	NC score	0.031102 (rank : 514)
Query Neighborhood Hits	351	Target Neighborhood Hits	2092	Shared Neighborhood Hits	113
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

IFT74_MOUSE
θ value	6.88961 (rank : 319)	NC score	0.048649 (rank : 478)
Query Neighborhood Hits	351	Target Neighborhood Hits	939	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

MAD3_HUMAN
θ value	6.88961 (rank : 320)	NC score	0.016162 (rank : 543)
Query Neighborhood Hits	351	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

NEDD1_MOUSE
θ value	6.88961 (rank : 321)	NC score	0.001605 (rank : 577)
Query Neighborhood Hits	351	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

NEK11_HUMAN
θ value	6.88961 (rank : 322)	NC score	0.005776 (rank : 569)
Query Neighborhood Hits	351	Target Neighborhood Hits	1043	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PELP1_HUMAN
θ value	6.88961 (rank : 323)	NC score	0.026607 (rank : 522)
Query Neighborhood Hits	351	Target Neighborhood Hits	596	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PICK1_HUMAN
θ value	6.88961 (rank : 324)	NC score	0.150812 (rank : 191)
Query Neighborhood Hits	351	Target Neighborhood Hits	132	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	6.88961 (rank : 325)	NC score	0.150364 (rank : 192)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RHPN2_HUMAN
θ value	6.88961 (rank : 326)	NC score	0.071086 (rank : 324)
Query Neighborhood Hits	351	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IUC4, Q8N3T7, Q8N9D6, Q8NE33, Q96RU1	Gene names	RHPN2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2) (76 kDa RhoB effector protein) (p76RBE).

SDPR_MOUSE
θ value	6.88961 (rank : 327)	NC score	0.033372 (rank : 512)
Query Neighborhood Hits	351	Target Neighborhood Hits	485	Shared Neighborhood Hits	55
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

SEN54_MOUSE
θ value	6.88961 (rank : 328)	NC score	0.009181 (rank : 561)
Query Neighborhood Hits	351	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C2A2, Q9DCI5	Gene names	Tsen54, Sen54
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen54 (tRNA-intron endonuclease Sen54).

UACA_MOUSE
θ value	6.88961 (rank : 329)	NC score	0.036438 (rank : 507)
Query Neighborhood Hits	351	Target Neighborhood Hits	1620	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

BSN_HUMAN
θ value	8.99809 (rank : 330)	NC score	0.042434 (rank : 497)
Query Neighborhood Hits	351	Target Neighborhood Hits	1537	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BUB1B_HUMAN
θ value	8.99809 (rank : 331)	NC score	0.015425 (rank : 545)
Query Neighborhood Hits	351	Target Neighborhood Hits	208	Shared Neighborhood Hits	26
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

CALD1_HUMAN
θ value	8.99809 (rank : 332)	NC score	0.045423 (rank : 489)
Query Neighborhood Hits	351	Target Neighborhood Hits	959	Shared Neighborhood Hits	87
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CING_MOUSE
θ value	8.99809 (rank : 333)	NC score	0.046757 (rank : 486)
Query Neighborhood Hits	351	Target Neighborhood Hits	1432	Shared Neighborhood Hits	99
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CP007_HUMAN
θ value	8.99809 (rank : 334)	NC score	0.008881 (rank : 562)
Query Neighborhood Hits	351	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2B5	Gene names	C16orf7, ATPBL
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 (Protein ATP-BL).

CUTL2_MOUSE
θ value	8.99809 (rank : 335)	NC score	0.020599 (rank : 532)
Query Neighborhood Hits	351	Target Neighborhood Hits	771	Shared Neighborhood Hits	67
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

EXOC2_MOUSE
θ value	8.99809 (rank : 336)	NC score	0.006797 (rank : 565)
Query Neighborhood Hits	351	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D4H1	Gene names	Exoc2, Sec5, Sec5l1
Domain Architecture
Description	Exocyst complex component 2 (Exocyst complex component Sec5).

FLIP1_HUMAN
θ value	8.99809 (rank : 337)	NC score	0.051855 (rank : 451)
Query Neighborhood Hits	351	Target Neighborhood Hits	1405	Shared Neighborhood Hits	100
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

HMMR_MOUSE
θ value	8.99809 (rank : 338)	NC score	0.051393 (rank : 456)
Query Neighborhood Hits	351	Target Neighborhood Hits	1178	Shared Neighborhood Hits	94
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

IF3A_HUMAN
θ value	8.99809 (rank : 339)	NC score	0.050985 (rank : 464)
Query Neighborhood Hits	351	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	8.99809 (rank : 340)	NC score	0.052155 (rank : 449)
Query Neighborhood Hits	351	Target Neighborhood Hits	871	Shared Neighborhood Hits	85
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

KIF17_MOUSE
θ value	8.99809 (rank : 341)	NC score	0.014111 (rank : 548)
Query Neighborhood Hits	351	Target Neighborhood Hits	452	Shared Neighborhood Hits	55
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

LPHN1_HUMAN
θ value	8.99809 (rank : 342)	NC score	0.000151 (rank : 580)
Query Neighborhood Hits	351	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	O94910, Q96IE7, Q9BU07, Q9HAR3	Gene names	LPHN1, KIAA0821, LEC2
Domain Architecture
Description	Latrophilin-1 precursor (Calcium-independent alpha-latrotoxin receptor 1) (Lectomedin-2).

NRIP1_MOUSE
θ value	8.99809 (rank : 343)	NC score	0.005717 (rank : 570)
Query Neighborhood Hits	351	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CBD1, Q8C3Y8, Q9Z2K2	Gene names	Nrip1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

PEPL_HUMAN
θ value	8.99809 (rank : 344)	NC score	0.052890 (rank : 439)
Query Neighborhood Hits	351	Target Neighborhood Hits	1141	Shared Neighborhood Hits	91
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

RAD50_MOUSE
θ value	8.99809 (rank : 345)	NC score	0.054283 (rank : 424)
Query Neighborhood Hits	351	Target Neighborhood Hits	1366	Shared Neighborhood Hits	97
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RFTN1_HUMAN
θ value	8.99809 (rank : 346)	NC score	0.006431 (rank : 566)
Query Neighborhood Hits	351	Target Neighborhood Hits	72	Shared Neighborhood Hits	6
SwissProt Accessions	Q14699, Q496Y2, Q4QQI7, Q5JB48, Q7Z7P2	Gene names	RFTN1, KIAA0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein) (Cell migration-inducing gene 2 protein).

SENP3_MOUSE
θ value	8.99809 (rank : 347)	NC score	0.016431 (rank : 542)
Query Neighborhood Hits	351	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).

SMC2_HUMAN
θ value	8.99809 (rank : 348)	NC score	0.047875 (rank : 482)
Query Neighborhood Hits	351	Target Neighborhood Hits	1405	Shared Neighborhood Hits	95
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SRRM2_MOUSE
θ value	8.99809 (rank : 349)	NC score	0.047349 (rank : 484)
Query Neighborhood Hits	351	Target Neighborhood Hits	1470	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TACC2_MOUSE
θ value	8.99809 (rank : 350)	NC score	0.038235 (rank : 504)
Query Neighborhood Hits	351	Target Neighborhood Hits	774	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

UTX_HUMAN
θ value	8.99809 (rank : 351)	NC score	0.003893 (rank : 575)
Query Neighborhood Hits	351	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

ABI1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.083730 (rank : 299)
Query Neighborhood Hits	351	Target Neighborhood Hits	257	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.090109 (rank : 280)
Query Neighborhood Hits	351	Target Neighborhood Hits	246	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.094602 (rank : 273)
Query Neighborhood Hits	351	Target Neighborhood Hits	350	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.092144 (rank : 277)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.077163 (rank : 310)
Query Neighborhood Hits	351	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.071871 (rank : 321)
Query Neighborhood Hits	351	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABR_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.213357 (rank : 156)
Query Neighborhood Hits	351	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

AHI1_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.072026 (rank : 320)
Query Neighborhood Hits	351	Target Neighborhood Hits	537	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.070077 (rank : 327)
Query Neighborhood Hits	351	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.063778 (rank : 365)
Query Neighborhood Hits	351	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.060005 (rank : 388)
Query Neighborhood Hits	351	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APXL_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.128240 (rank : 208)
Query Neighborhood Hits	351	Target Neighborhood Hits	553	Shared Neighborhood Hits	108
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARHG7_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.313346 (rank : 83)
Query Neighborhood Hits	351	Target Neighborhood Hits	396	Shared Neighborhood Hits	86
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHGA_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.388768 (rank : 53)
Query Neighborhood Hits	351	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ASPP1_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.051238 (rank : 459)
Query Neighborhood Hits	351	Target Neighborhood Hits	956	Shared Neighborhood Hits	86
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.056911 (rank : 406)
Query Neighborhood Hits	351	Target Neighborhood Hits	1244	Shared Neighborhood Hits	102
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

AZI1_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.053284 (rank : 436)
Query Neighborhood Hits	351	Target Neighborhood Hits	1000	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BAIP2_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.062467 (rank : 373)
Query Neighborhood Hits	351	Target Neighborhood Hits	192	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.063192 (rank : 370)
Query Neighborhood Hits	351	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.062419 (rank : 374)
Query Neighborhood Hits	351	Target Neighborhood Hits	554	Shared Neighborhood Hits	43
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.062657 (rank : 372)
Query Neighborhood Hits	351	Target Neighborhood Hits	438	Shared Neighborhood Hits	40
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCR_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.222041 (rank : 154)
Query Neighborhood Hits	351	Target Neighborhood Hits	204	Shared Neighborhood Hits	59
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.086592 (rank : 293)
Query Neighborhood Hits	351	Target Neighborhood Hits	156	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.072879 (rank : 317)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CAR10_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.052963 (rank : 437)
Query Neighborhood Hits	351	Target Neighborhood Hits	569	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CAR11_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.072570 (rank : 318)
Query Neighborhood Hits	351	Target Neighborhood Hits	690	Shared Neighborhood Hits	99
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CASL_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.057382 (rank : 403)
Query Neighborhood Hits	351	Target Neighborhood Hits	259	Shared Neighborhood Hits	30
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.051863 (rank : 450)
Query Neighborhood Hits	351	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CCD13_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.053709 (rank : 432)
Query Neighborhood Hits	351	Target Neighborhood Hits	721	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD46_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.051449 (rank : 455)
Query Neighborhood Hits	351	Target Neighborhood Hits	1430	Shared Neighborhood Hits	105
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCD96_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.054922 (rank : 417)
Query Neighborhood Hits	351	Target Neighborhood Hits	595	Shared Neighborhood Hits	68
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCD96_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.052862 (rank : 440)
Query Neighborhood Hits	351	Target Neighborhood Hits	704	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CD2AP_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.132179 (rank : 204)
Query Neighborhood Hits	351	Target Neighborhood Hits	315	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.131319 (rank : 205)
Query Neighborhood Hits	351	Target Neighborhood Hits	336	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CENPF_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.052604 (rank : 441)
Query Neighborhood Hits	351	Target Neighborhood Hits	1932	Shared Neighborhood Hits	119
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CEP63_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.052317 (rank : 448)
Query Neighborhood Hits	351	Target Neighborhood Hits	1005	Shared Neighborhood Hits	90
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CI093_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.050619 (rank : 466)
Query Neighborhood Hits	351	Target Neighborhood Hits	1088	Shared Neighborhood Hits	92
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CNKR2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.064731 (rank : 360)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.064840 (rank : 358)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNTRB_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.051102 (rank : 462)
Query Neighborhood Hits	351	Target Neighborhood Hits	1029	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.051160 (rank : 460)
Query Neighborhood Hits	351	Target Neighborhood Hits	1278	Shared Neighborhood Hits	95
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CRKL_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.096438 (rank : 270)
Query Neighborhood Hits	351	Target Neighborhood Hits	313	Shared Neighborhood Hits	34
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.093875 (rank : 274)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.088436 (rank : 286)
Query Neighborhood Hits	351	Target Neighborhood Hits	308	Shared Neighborhood Hits	34
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.090759 (rank : 279)
Query Neighborhood Hits	351	Target Neighborhood Hits	314	Shared Neighborhood Hits	35
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.057668 (rank : 401)
Query Neighborhood Hits	351	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.071812 (rank : 322)
Query Neighborhood Hits	351	Target Neighborhood Hits	244	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.068128 (rank : 340)
Query Neighborhood Hits	351	Target Neighborhood Hits	306	Shared Neighborhood Hits	33
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DVL1L_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.110369 (rank : 251)
Query Neighborhood Hits	351	Target Neighborhood Hits	146	Shared Neighborhood Hits	89
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.118679 (rank : 223)
Query Neighborhood Hits	351	Target Neighborhood Hits	158	Shared Neighborhood Hits	92
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.116508 (rank : 227)
Query Neighborhood Hits	351	Target Neighborhood Hits	146	Shared Neighborhood Hits	90
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL2_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.111171 (rank : 250)
Query Neighborhood Hits	351	Target Neighborhood Hits	223	Shared Neighborhood Hits	92
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.111493 (rank : 245)
Query Neighborhood Hits	351	Target Neighborhood Hits	233	Shared Neighborhood Hits	92
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.118585 (rank : 224)
Query Neighborhood Hits	351	Target Neighborhood Hits	194	Shared Neighborhood Hits	87
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.118826 (rank : 222)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	89
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

EEA1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.065058 (rank : 357)
Query Neighborhood Hits	351	Target Neighborhood Hits	1796	Shared Neighborhood Hits	116
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.064383 (rank : 362)
Query Neighborhood Hits	351	Target Neighborhood Hits	1637	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.058616 (rank : 394)
Query Neighborhood Hits	351	Target Neighborhood Hits	348	Shared Neighborhood Hits	38
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.060586 (rank : 386)
Query Neighborhood Hits	351	Target Neighborhood Hits	389	Shared Neighborhood Hits	38
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EM55_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.142380 (rank : 196)
Query Neighborhood Hits	351	Target Neighborhood Hits	228	Shared Neighborhood Hits	107
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.140514 (rank : 198)
Query Neighborhood Hits	351	Target Neighborhood Hits	221	Shared Neighborhood Hits	106
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ENAH_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.055135 (rank : 415)
Query Neighborhood Hits	351	Target Neighborhood Hits	784	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

EP15R_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.068922 (rank : 332)
Query Neighborhood Hits	351	Target Neighborhood Hits	1083	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.073126 (rank : 316)
Query Neighborhood Hits	351	Target Neighborhood Hits	1135	Shared Neighborhood Hits	92
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.068420 (rank : 337)
Query Neighborhood Hits	351	Target Neighborhood Hits	1021	Shared Neighborhood Hits	87
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.068548 (rank : 333)
Query Neighborhood Hits	351	Target Neighborhood Hits	820	Shared Neighborhood Hits	72
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FYCO1_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.058749 (rank : 393)
Query Neighborhood Hits	351	Target Neighborhood Hits	1149	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.060251 (rank : 387)
Query Neighborhood Hits	351	Target Neighborhood Hits	1059	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GNRP_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.279874 (rank : 118)
Query Neighborhood Hits	351	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.302413 (rank : 99)
Query Neighborhood Hits	351	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP2_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.089161 (rank : 284)
Query Neighborhood Hits	351	Target Neighborhood Hits	304	Shared Neighborhood Hits	33
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.087955 (rank : 291)
Query Neighborhood Hits	351	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.114103 (rank : 235)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	36
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.113209 (rank : 239)
Query Neighborhood Hits	351	Target Neighborhood Hits	309	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.108039 (rank : 254)
Query Neighborhood Hits	351	Target Neighborhood Hits	310	Shared Neighborhood Hits	37
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.108108 (rank : 253)
Query Neighborhood Hits	351	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.090046 (rank : 281)
Query Neighborhood Hits	351	Target Neighborhood Hits	358	Shared Neighborhood Hits	31
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.090838 (rank : 278)
Query Neighborhood Hits	351	Target Neighborhood Hits	329	Shared Neighborhood Hits	35
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.063993 (rank : 364)
Query Neighborhood Hits	351	Target Neighborhood Hits	517	Shared Neighborhood Hits	51
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.066731 (rank : 345)
Query Neighborhood Hits	351	Target Neighborhood Hits	589	Shared Neighborhood Hits	58
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IFT74_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.051686 (rank : 453)
Query Neighborhood Hits	351	Target Neighborhood Hits	949	Shared Neighborhood Hits	75
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.057762 (rank : 399)
Query Neighborhood Hits	351	Target Neighborhood Hits	959	Shared Neighborhood Hits	85
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IL16_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.225293 (rank : 152)
Query Neighborhood Hits	351	Target Neighborhood Hits	207	Shared Neighborhood Hits	110
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IL16_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.211551 (rank : 158)
Query Neighborhood Hits	351	Target Neighborhood Hits	189	Shared Neighborhood Hits	102
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

INCE_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.050246 (rank : 469)
Query Neighborhood Hits	351	Target Neighborhood Hits	903	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INVO_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.053407 (rank : 435)
Query Neighborhood Hits	351	Target Neighborhood Hits	636	Shared Neighborhood Hits	65
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

K1849_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.185803 (rank : 176)
Query Neighborhood Hits	351	Target Neighborhood Hits	220	Shared Neighborhood Hits	117
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.178320 (rank : 179)
Query Neighborhood Hits	351	Target Neighborhood Hits	335	Shared Neighborhood Hits	123
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

KGUA_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.068135 (rank : 339)
Query Neighborhood Hits	351	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.068486 (rank : 335)
Query Neighborhood Hits	351	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LASP1_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.069166 (rank : 331)
Query Neighborhood Hits	351	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.066969 (rank : 344)
Query Neighborhood Hits	351	Target Neighborhood Hits	297	Shared Neighborhood Hits	26
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LRC45_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.052416 (rank : 445)
Query Neighborhood Hits	351	Target Neighborhood Hits	959	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MD1L1_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.051665 (rank : 454)
Query Neighborhood Hits	351	Target Neighborhood Hits	1001	Shared Neighborhood Hits	81
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MOES_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.052454 (rank : 443)
Query Neighborhood Hits	351	Target Neighborhood Hits	892	Shared Neighborhood Hits	87
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.052392 (rank : 447)
Query Neighborhood Hits	351	Target Neighborhood Hits	923	Shared Neighborhood Hits	89
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MPP2_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.111475 (rank : 246)
Query Neighborhood Hits	351	Target Neighborhood Hits	173	Shared Neighborhood Hits	84
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.111854 (rank : 243)
Query Neighborhood Hits	351	Target Neighborhood Hits	189	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.146584 (rank : 193)
Query Neighborhood Hits	351	Target Neighborhood Hits	188	Shared Neighborhood Hits	100
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP5_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.152899 (rank : 188)
Query Neighborhood Hits	351	Target Neighborhood Hits	231	Shared Neighborhood Hits	104
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.151664 (rank : 190)
Query Neighborhood Hits	351	Target Neighborhood Hits	226	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.119322 (rank : 221)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.120319 (rank : 218)
Query Neighborhood Hits	351	Target Neighborhood Hits	187	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NCF1_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.139191 (rank : 199)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.129391 (rank : 207)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.121335 (rank : 213)
Query Neighborhood Hits	351	Target Neighborhood Hits	229	Shared Neighborhood Hits	34
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.095316 (rank : 271)
Query Neighborhood Hits	351	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.094714 (rank : 272)
Query Neighborhood Hits	351	Target Neighborhood Hits	177	Shared Neighborhood Hits	20
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.119379 (rank : 220)
Query Neighborhood Hits	351	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.111448 (rank : 247)
Query Neighborhood Hits	351	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.070367 (rank : 326)
Query Neighborhood Hits	351	Target Neighborhood Hits	457	Shared Neighborhood Hits	66
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.053470 (rank : 434)
Query Neighborhood Hits	351	Target Neighborhood Hits	420	Shared Neighborhood Hits	41
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NOS1_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.116181 (rank : 228)
Query Neighborhood Hits	351	Target Neighborhood Hits	218	Shared Neighborhood Hits	108
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOS1_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.089992 (rank : 282)
Query Neighborhood Hits	351	Target Neighborhood Hits	155	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOXO1_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.072569 (rank : 319)
Query Neighborhood Hits	351	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.076369 (rank : 313)
Query Neighborhood Hits	351	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.063262 (rank : 369)
Query Neighborhood Hits	351	Target Neighborhood Hits	288	Shared Neighborhood Hits	35
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.077526 (rank : 309)
Query Neighborhood Hits	351	Target Neighborhood Hits	267	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OBSCN_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.051015 (rank : 463)
Query Neighborhood Hits	351	Target Neighborhood Hits	1931	Shared Neighborhood Hits	85
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OSTF1_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.071280 (rank : 323)
Query Neighborhood Hits	351	Target Neighborhood Hits	466	Shared Neighborhood Hits	37
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.069319 (rank : 330)
Query Neighborhood Hits	351	Target Neighborhood Hits	467	Shared Neighborhood Hits	36
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85B_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.054368 (rank : 422)
Query Neighborhood Hits	351	Target Neighborhood Hits	543	Shared Neighborhood Hits	62
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.051157 (rank : 461)
Query Neighborhood Hits	351	Target Neighborhood Hits	519	Shared Neighborhood Hits	59
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.065102 (rank : 356)
Query Neighborhood Hits	351	Target Neighborhood Hits	320	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.062319 (rank : 376)
Query Neighborhood Hits	351	Target Neighborhood Hits	283	Shared Neighborhood Hits	36
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.062385 (rank : 375)
Query Neighborhood Hits	351	Target Neighborhood Hits	339	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.066437 (rank : 347)
Query Neighborhood Hits	351	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.065600 (rank : 352)
Query Neighborhood Hits	351	Target Neighborhood Hits	385	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.064000 (rank : 363)
Query Neighborhood Hits	351	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PAR6A_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.115250 (rank : 231)
Query Neighborhood Hits	351	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.115831 (rank : 230)
Query Neighborhood Hits	351	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6B_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.121124 (rank : 214)
Query Neighborhood Hits	351	Target Neighborhood Hits	126	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.120289 (rank : 219)
Query Neighborhood Hits	351	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.122552 (rank : 212)
Query Neighborhood Hits	351	Target Neighborhood Hits	159	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.120331 (rank : 217)
Query Neighborhood Hits	351	Target Neighborhood Hits	121	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PCLO_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.088938 (rank : 285)
Query Neighborhood Hits	351	Target Neighborhood Hits	2275	Shared Neighborhood Hits	169
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PCNT_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.059018 (rank : 392)
Query Neighborhood Hits	351	Target Neighborhood Hits	1551	Shared Neighborhood Hits	102
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PCQAP_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.050079 (rank : 471)
Query Neighborhood Hits	351	Target Neighborhood Hits	549	Shared Neighborhood Hits	51
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PDLI1_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.111358 (rank : 248)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	89
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.111545 (rank : 244)
Query Neighborhood Hits	351	Target Neighborhood Hits	213	Shared Neighborhood Hits	91
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.116131 (rank : 229)
Query Neighborhood Hits	351	Target Neighborhood Hits	199	Shared Neighborhood Hits	93
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.109136 (rank : 252)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	89
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.112039 (rank : 242)
Query Neighborhood Hits	351	Target Neighborhood Hits	245	Shared Neighborhood Hits	98
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.114453 (rank : 233)
Query Neighborhood Hits	351	Target Neighborhood Hits	233	Shared Neighborhood Hits	99
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI7_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.099287 (rank : 266)
Query Neighborhood Hits	351	Target Neighborhood Hits	547	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.093287 (rank : 275)
Query Neighborhood Hits	351	Target Neighborhood Hits	279	Shared Neighborhood Hits	90
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZD6_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.058537 (rank : 395)
Query Neighborhood Hits	351	Target Neighborhood Hits	81	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDZK4_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.152924 (rank : 187)
Query Neighborhood Hits	351	Target Neighborhood Hits	165	Shared Neighborhood Hits	98
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.152179 (rank : 189)
Query Neighborhood Hits	351	Target Neighborhood Hits	165	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PEX13_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.057304 (rank : 404)
Query Neighborhood Hits	351	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.058276 (rank : 397)
Query Neighborhood Hits	351	Target Neighborhood Hits	126	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PIBF1_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.052519 (rank : 442)
Query Neighborhood Hits	351	Target Neighborhood Hits	1041	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PKHF1_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.106058 (rank : 256)
Query Neighborhood Hits	351	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.105131 (rank : 257)
Query Neighborhood Hits	351	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.113264 (rank : 238)
Query Neighborhood Hits	351	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.112615 (rank : 241)
Query Neighborhood Hits	351	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG4_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.247577 (rank : 140)
Query Neighborhood Hits	351	Target Neighborhood Hits	200	Shared Neighborhood Hits	57
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.080287 (rank : 303)
Query Neighborhood Hits	351	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.082030 (rank : 300)
Query Neighborhood Hits	351	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.069885 (rank : 328)
Query Neighborhood Hits	351	Target Neighborhood Hits	280	Shared Neighborhood Hits	18
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.087991 (rank : 290)
Query Neighborhood Hits	351	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.085866 (rank : 295)
Query Neighborhood Hits	351	Target Neighborhood Hits	377	Shared Neighborhood Hits	59
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTN4_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.084240 (rank : 298)
Query Neighborhood Hits	351	Target Neighborhood Hits	303	Shared Neighborhood Hits	108
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

RB6I2_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.050247 (rank : 468)
Query Neighborhood Hits	351	Target Neighborhood Hits	1584	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.050962 (rank : 465)
Query Neighborhood Hits	351	Target Neighborhood Hits	1433	Shared Neighborhood Hits	103
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBNS5_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.061274 (rank : 383)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.058103 (rank : 398)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	41
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.061666 (rank : 379)
Query Neighborhood Hits	351	Target Neighborhood Hits	205	Shared Neighborhood Hits	15
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.063777 (rank : 366)
Query Neighborhood Hits	351	Target Neighborhood Hits	204	Shared Neighborhood Hits	16
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.074624 (rank : 315)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.078217 (rank : 306)
Query Neighborhood Hits	351	Target Neighborhood Hits	102	Shared Neighborhood Hits	12
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RFIP3_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.053715 (rank : 431)
Query Neighborhood Hits	351	Target Neighborhood Hits	1055	Shared Neighborhood Hits	90
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RHG04_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.056695 (rank : 407)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	37
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.068472 (rank : 336)
Query Neighborhood Hits	351	Target Neighborhood Hits	1479	Shared Neighborhood Hits	122
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.063280 (rank : 368)
Query Neighborhood Hits	351	Target Neighborhood Hits	1376	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.057593 (rank : 402)
Query Neighborhood Hits	351	Target Neighborhood Hits	263	Shared Neighborhood Hits	26
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.059602 (rank : 390)
Query Neighborhood Hits	351	Target Neighborhood Hits	246	Shared Neighborhood Hits	27
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMS1_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.088108 (rank : 289)
Query Neighborhood Hits	351	Target Neighborhood Hits	437	Shared Neighborhood Hits	106
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.065971 (rank : 350)
Query Neighborhood Hits	351	Target Neighborhood Hits	342	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.065636 (rank : 351)
Query Neighborhood Hits	351	Target Neighborhood Hits	376	Shared Neighborhood Hits	91
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.061931 (rank : 378)
Query Neighborhood Hits	351	Target Neighborhood Hits	848	Shared Neighborhood Hits	90
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.061360 (rank : 382)
Query Neighborhood Hits	351	Target Neighborhood Hits	765	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.066557 (rank : 346)
Query Neighborhood Hits	351	Target Neighborhood Hits	1208	Shared Neighborhood Hits	104
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.061458 (rank : 381)
Query Neighborhood Hits	351	Target Neighborhood Hits	820	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SDCG8_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.050486 (rank : 467)
Query Neighborhood Hits	351	Target Neighborhood Hits	1002	Shared Neighborhood Hits	88
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SH3G1_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.079517 (rank : 304)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.077122 (rank : 311)
Query Neighborhood Hits	351	Target Neighborhood Hits	291	Shared Neighborhood Hits	44
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.078325 (rank : 305)
Query Neighborhood Hits	351	Target Neighborhood Hits	324	Shared Neighborhood Hits	46
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.076369 (rank : 312)
Query Neighborhood Hits	351	Target Neighborhood Hits	319	Shared Neighborhood Hits	44
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.077998 (rank : 307)
Query Neighborhood Hits	351	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.080625 (rank : 302)
Query Neighborhood Hits	351	Target Neighborhood Hits	236	Shared Neighborhood Hits	30
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.137133 (rank : 201)
Query Neighborhood Hits	351	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.126368 (rank : 211)
Query Neighborhood Hits	351	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOS1_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.144084 (rank : 194)
Query Neighborhood Hits	351	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.136235 (rank : 202)
Query Neighborhood Hits	351	Target Neighborhood Hits	281	Shared Neighborhood Hits	50
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.057668 (rank : 400)
Query Neighborhood Hits	351	Target Neighborhood Hits	748	Shared Neighborhood Hits	83
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.061039 (rank : 385)
Query Neighborhood Hits	351	Target Neighborhood Hits	675	Shared Neighborhood Hits	76
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.067670 (rank : 342)
Query Neighborhood Hits	351	Target Neighborhood Hits	888	Shared Neighborhood Hits	91
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.116863 (rank : 226)
Query Neighborhood Hits	351	Target Neighborhood Hits	396	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.120757 (rank : 215)
Query Neighborhood Hits	351	Target Neighborhood Hits	409	Shared Neighborhood Hits	37
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.088242 (rank : 288)
Query Neighborhood Hits	351	Target Neighborhood Hits	269	Shared Neighborhood Hits	32
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.088293 (rank : 287)
Query Neighborhood Hits	351	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.087797 (rank : 292)
Query Neighborhood Hits	351	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.089346 (rank : 283)
Query Neighborhood Hits	351	Target Neighborhood Hits	232	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.103391 (rank : 262)
Query Neighborhood Hits	351	Target Neighborhood Hits	276	Shared Neighborhood Hits	29
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.102342 (rank : 263)
Query Neighborhood Hits	351	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.102321 (rank : 264)
Query Neighborhood Hits	351	Target Neighborhood Hits	271	Shared Neighborhood Hits	38
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.105056 (rank : 258)
Query Neighborhood Hits	351	Target Neighborhood Hits	273	Shared Neighborhood Hits	37
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.096685 (rank : 269)
Query Neighborhood Hits	351	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.097825 (rank : 268)
Query Neighborhood Hits	351	Target Neighborhood Hits	285	Shared Neighborhood Hits	38
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STXB4_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.140744 (rank : 197)
Query Neighborhood Hits	351	Target Neighborhood Hits	616	Shared Neighborhood Hits	136
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.133626 (rank : 203)
Query Neighborhood Hits	351	Target Neighborhood Hits	629	Shared Neighborhood Hits	127
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SWP70_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.055382 (rank : 412)
Query Neighborhood Hits	351	Target Neighborhood Hits	973	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.054008 (rank : 429)
Query Neighborhood Hits	351	Target Neighborhood Hits	1097	Shared Neighborhood Hits	105
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

T2_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.055636 (rank : 411)
Query Neighborhood Hits	351	Target Neighborhood Hits	140	Shared Neighborhood Hits	24
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

TAXB1_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.052440 (rank : 444)
Query Neighborhood Hits	351	Target Neighborhood Hits	829	Shared Neighborhood Hits	72
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.054985 (rank : 416)
Query Neighborhood Hits	351	Target Neighborhood Hits	872	Shared Neighborhood Hits	56
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.062048 (rank : 377)
Query Neighborhood Hits	351	Target Neighborhood Hits	409	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TRIPB_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.050166 (rank : 470)
Query Neighborhood Hits	351	Target Neighborhood Hits	1587	Shared Neighborhood Hits	114
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

VINEX_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.112668 (rank : 240)
Query Neighborhood Hits	351	Target Neighborhood Hits	270	Shared Neighborhood Hits	32
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.113296 (rank : 237)
Query Neighborhood Hits	351	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

XE7_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.054150 (rank : 426)
Query Neighborhood Hits	351	Target Neighborhood Hits	738	Shared Neighborhood Hits	76
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

ZC313_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.052936 (rank : 438)
Query Neighborhood Hits	351	Target Neighborhood Hits	772	Shared Neighborhood Hits	71
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZFY16_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.064810 (rank : 359)
Query Neighborhood Hits	351	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.065988 (rank : 349)
Query Neighborhood Hits	351	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.061643 (rank : 380)
Query Neighborhood Hits	351	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.063476 (rank : 367)
Query Neighborhood Hits	351	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.070404 (rank : 325)
Query Neighborhood Hits	351	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.069573 (rank : 329)
Query Neighborhood Hits	351	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ARHGC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	351	Target Neighborhood Hits	351	Shared Neighborhood Hits	351
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.989637 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	351	Target Neighborhood Hits	344	Shared Neighborhood Hits	271
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGB_HUMAN
NC score	0.922384 (rank : 3)	θ value	4.1775e-114 (rank : 5)
Query Neighborhood Hits	351	Target Neighborhood Hits	375	Shared Neighborhood Hits	208
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG1_HUMAN
NC score	0.860930 (rank : 4)	θ value	3.41741e-116 (rank : 4)
Query Neighborhood Hits	351	Target Neighborhood Hits	176	Shared Neighborhood Hits	66
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.842185 (rank : 5)	θ value	1.28662e-147 (rank : 3)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	67
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

LBC_HUMAN
NC score	0.787216 (rank : 6)	θ value	2.11701e-41 (rank : 6)
Query Neighborhood Hits	351	Target Neighborhood Hits	90	Shared Neighborhood Hits	61
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_MOUSE
NC score	0.770334 (rank : 7)	θ value	8.04462e-41 (rank : 8)
Query Neighborhood Hits	351	Target Neighborhood Hits	120	Shared Neighborhood Hits	67
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
NC score	0.758059 (rank : 8)	θ value	3.05695e-40 (rank : 9)
Query Neighborhood Hits	351	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

RGNEF_MOUSE
NC score	0.667247 (rank : 9)	θ value	2.11701e-41 (rank : 7)
Query Neighborhood Hits	351	Target Neighborhood Hits	641	Shared Neighborhood Hits	125
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG3_HUMAN
NC score	0.659847 (rank : 10)	θ value	2.13179e-17 (rank : 16)
Query Neighborhood Hits	351	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.659546 (rank : 11)	θ value	8.10077e-17 (rank : 17)
Query Neighborhood Hits	351	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
NC score	0.646627 (rank : 12)	θ value	1.63225e-17 (rank : 15)
Query Neighborhood Hits	351	Target Neighborhood Hits	85	Shared Neighborhood Hits	62
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
NC score	0.642912 (rank : 13)	θ value	2.60593e-15 (rank : 22)
Query Neighborhood Hits	351	Target Neighborhood Hits	129	Shared Neighborhood Hits	66
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG8_MOUSE
NC score	0.641012 (rank : 14)	θ value	8.65492e-19 (rank : 14)
Query Neighborhood Hits	351	Target Neighborhood Hits	79	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.630488 (rank : 15)	θ value	2.88119e-14 (rank : 24)
Query Neighborhood Hits	351	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.614149 (rank : 16)	θ value	5.25075e-16 (rank : 19)
Query Neighborhood Hits	351	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
NC score	0.613095 (rank : 17)	θ value	3.52202e-12 (rank : 29)
Query Neighborhood Hits	351	Target Neighborhood Hits	172	Shared Neighborhood Hits	67
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ECT2_MOUSE
NC score	0.612015 (rank : 18)	θ value	1.68911e-14 (rank : 23)
Query Neighborhood Hits	351	Target Neighborhood Hits	98	Shared Neighborhood Hits	68
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NGEF_MOUSE
NC score	0.608032 (rank : 19)	θ value	3.07829e-16 (rank : 18)
Query Neighborhood Hits	351	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ECT2_HUMAN
NC score	0.595982 (rank : 20)	θ value	5.43371e-13 (rank : 26)
Query Neighborhood Hits	351	Target Neighborhood Hits	98	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGF_HUMAN
NC score	0.587107 (rank : 21)	θ value	2.28291e-11 (rank : 34)
Query Neighborhood Hits	351	Target Neighborhood Hits	214	Shared Neighborhood Hits	64
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PREX1_HUMAN
NC score	0.557225 (rank : 22)	θ value	3.08544e-08 (rank : 44)
Query Neighborhood Hits	351	Target Neighborhood Hits	177	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_HUMAN
NC score	0.542809 (rank : 23)	θ value	2.21117e-06 (rank : 56)
Query Neighborhood Hits	351	Target Neighborhood Hits	225	Shared Neighborhood Hits	125
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.540782 (rank : 24)	θ value	4.45536e-07 (rank : 48)
Query Neighborhood Hits	351	Target Neighborhood Hits	205	Shared Neighborhood Hits	104
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
NC score	0.534373 (rank : 25)	θ value	2.52405e-10 (rank : 39)
Query Neighborhood Hits	351	Target Neighborhood Hits	185	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_MOUSE
NC score	0.533705 (rank : 26)	θ value	1.06045e-08 (rank : 43)
Query Neighborhood Hits	351	Target Neighborhood Hits	257	Shared Neighborhood Hits	69
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHG9_HUMAN
NC score	0.527936 (rank : 27)	θ value	5.08577e-11 (rank : 36)
Query Neighborhood Hits	351	Target Neighborhood Hits	235	Shared Neighborhood Hits	76
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.527449 (rank : 28)	θ value	5.08577e-11 (rank : 37)
Query Neighborhood Hits	351	Target Neighborhood Hits	234	Shared Neighborhood Hits	76
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGD4_HUMAN
NC score	0.519705 (rank : 29)	θ value	1.09485e-13 (rank : 25)
Query Neighborhood Hits	351	Target Neighborhood Hits	219	Shared Neighborhood Hits	75
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.516911 (rank : 30)	θ value	3.52202e-12 (rank : 30)
Query Neighborhood Hits	351	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
NC score	0.511194 (rank : 31)	θ value	9.59137e-10 (rank : 40)
Query Neighborhood Hits	351	Target Neighborhood Hits	249	Shared Neighborhood Hits	67
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHG4_HUMAN
NC score	0.510107 (rank : 32)	θ value	1.63604e-09 (rank : 41)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_MOUSE
NC score	0.509953 (rank : 33)	θ value	3.89403e-11 (rank : 35)
Query Neighborhood Hits	351	Target Neighborhood Hits	163	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

PKHG1_HUMAN
NC score	0.501372 (rank : 34)	θ value	9.92553e-07 (rank : 51)
Query Neighborhood Hits	351	Target Neighborhood Hits	174	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FGD2_HUMAN
NC score	0.501134 (rank : 35)	θ value	1.06045e-08 (rank : 42)
Query Neighborhood Hits	351	Target Neighborhood Hits	151	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD1_MOUSE
NC score	0.494309 (rank : 36)	θ value	6.00763e-12 (rank : 31)
Query Neighborhood Hits	351	Target Neighborhood Hits	387	Shared Neighborhood Hits	74
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.490425 (rank : 37)	θ value	6.64225e-11 (rank : 38)
Query Neighborhood Hits	351	Target Neighborhood Hits	367	Shared Neighborhood Hits	75
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ITSN2_HUMAN
NC score	0.470165 (rank : 38)	θ value	4.14116e-29 (rank : 10)
Query Neighborhood Hits	351	Target Neighborhood Hits	1173	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_MOUSE
NC score	0.459925 (rank : 39)	θ value	6.85773e-16 (rank : 21)
Query Neighborhood Hits	351	Target Neighborhood Hits	430	Shared Neighborhood Hits	72
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_HUMAN
NC score	0.457078 (rank : 40)	θ value	7.09661e-13 (rank : 27)
Query Neighborhood Hits	351	Target Neighborhood Hits	453	Shared Neighborhood Hits	72
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.454229 (rank : 41)	θ value	7.84624e-12 (rank : 33)
Query Neighborhood Hits	351	Target Neighborhood Hits	456	Shared Neighborhood Hits	73
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

MCF2_HUMAN
NC score	0.452527 (rank : 42)	θ value	7.1131e-05 (rank : 75)
Query Neighborhood Hits	351	Target Neighborhood Hits	166	Shared Neighborhood Hits	77
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ITSN2_MOUSE
NC score	0.447962 (rank : 43)	θ value	1.33217e-27 (rank : 11)
Query Neighborhood Hits	351	Target Neighborhood Hits	1371	Shared Neighborhood Hits	155
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_HUMAN
NC score	0.446072 (rank : 44)	θ value	6.85773e-16 (rank : 20)
Query Neighborhood Hits	351	Target Neighborhood Hits	452	Shared Neighborhood Hits	74
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGA_HUMAN
NC score	0.433573 (rank : 45)	θ value	1.43324e-05 (rank : 63)
Query Neighborhood Hits	351	Target Neighborhood Hits	187	Shared Neighborhood Hits	67
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ITSN1_HUMAN
NC score	0.431551 (rank : 46)	θ value	6.61148e-27 (rank : 12)
Query Neighborhood Hits	351	Target Neighborhood Hits	1757	Shared Neighborhood Hits	162
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.430576 (rank : 47)	θ value	6.61148e-27 (rank : 13)
Query Neighborhood Hits	351	Target Neighborhood Hits	1669	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV3_MOUSE
NC score	0.429827 (rank : 48)	θ value	6.00763e-12 (rank : 32)
Query Neighborhood Hits	351	Target Neighborhood Hits	404	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.428794 (rank : 49)	θ value	1.58096e-12 (rank : 28)
Query Neighborhood Hits	351	Target Neighborhood Hits	398	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

MCF2L_MOUSE
NC score	0.420510 (rank : 50)	θ value	0.00134147 (rank : 107)
Query Neighborhood Hits	351	Target Neighborhood Hits	255	Shared Neighborhood Hits	83
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FGD6_MOUSE
NC score	0.406340 (rank : 51)	θ value	7.1131e-05 (rank : 74)
Query Neighborhood Hits	351	Target Neighborhood Hits	282	Shared Neighborhood Hits	73
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.403252 (rank : 52)	θ value	0.000158464 (rank : 79)
Query Neighborhood Hits	351	Target Neighborhood Hits	237	Shared Neighborhood Hits	65
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHGA_MOUSE
NC score	0.388768 (rank : 53)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	351	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

DNMBP_MOUSE
NC score	0.388178 (rank : 54)	θ value	0.00665767 (rank : 132)
Query Neighborhood Hits	351	Target Neighborhood Hits	435	Shared Neighborhood Hits	80
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PDZD1_MOUSE
NC score	0.380390 (rank : 55)	θ value	3.41135e-07 (rank : 47)
Query Neighborhood Hits	351	Target Neighborhood Hits	191	Shared Neighborhood Hits	137
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DNMBP_HUMAN
NC score	0.379601 (rank : 56)	θ value	0.00869519 (rank : 137)
Query Neighborhood Hits	351	Target Neighborhood Hits	413	Shared Neighborhood Hits	83
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PDZD1_HUMAN
NC score	0.367339 (rank : 57)	θ value	1.09739e-05 (rank : 61)
Query Neighborhood Hits	351	Target Neighborhood Hits	190	Shared Neighborhood Hits	142
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

NHERF_MOUSE
NC score	0.360409 (rank : 58)	θ value	4.92598e-06 (rank : 59)
Query Neighborhood Hits	351	Target Neighborhood Hits	195	Shared Neighborhood Hits	137
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

HAPIP_HUMAN
NC score	0.357885 (rank : 59)	θ value	0.000121331 (rank : 77)
Query Neighborhood Hits	351	Target Neighborhood Hits	350	Shared Neighborhood Hits	99
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PDZD3_HUMAN
NC score	0.356468 (rank : 60)	θ value	1.09739e-05 (rank : 62)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	137
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

USH1C_HUMAN
NC score	0.356369 (rank : 61)	θ value	4.1701e-05 (rank : 70)
Query Neighborhood Hits	351	Target Neighborhood Hits	327	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZD7_HUMAN
NC score	0.354950 (rank : 62)	θ value	0.00175202 (rank : 115)
Query Neighborhood Hits	351	Target Neighborhood Hits	181	Shared Neighborhood Hits	141
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

NHERF_HUMAN
NC score	0.350525 (rank : 63)	θ value	0.000270298 (rank : 84)
Query Neighborhood Hits	351	Target Neighborhood Hits	190	Shared Neighborhood Hits	138
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
NC score	0.347894 (rank : 64)	θ value	0.000270298 (rank : 85)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	141
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

SYJ2B_HUMAN
NC score	0.345654 (rank : 65)	θ value	0.000270298 (rank : 86)
Query Neighborhood Hits	351	Target Neighborhood Hits	162	Shared Neighborhood Hits	122
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

ARHG7_HUMAN
NC score	0.344234 (rank : 66)	θ value	0.000270298 (rank : 83)
Query Neighborhood Hits	351	Target Neighborhood Hits	347	Shared Neighborhood Hits	86
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PDZD3_MOUSE
NC score	0.342550 (rank : 67)	θ value	0.00020696 (rank : 80)
Query Neighborhood Hits	351	Target Neighborhood Hits	171	Shared Neighborhood Hits	134
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

WHRN_MOUSE
NC score	0.341646 (rank : 68)	θ value	0.00020696 (rank : 82)
Query Neighborhood Hits	351	Target Neighborhood Hits	412	Shared Neighborhood Hits	157
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WHRN_HUMAN
NC score	0.340572 (rank : 69)	θ value	0.000602161 (rank : 97)
Query Neighborhood Hits	351	Target Neighborhood Hits	325	Shared Neighborhood Hits	156
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

USH1C_MOUSE
NC score	0.335846 (rank : 70)	θ value	0.00102713 (rank : 106)
Query Neighborhood Hits	351	Target Neighborhood Hits	557	Shared Neighborhood Hits	175
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

LIN7A_MOUSE
NC score	0.335066 (rank : 71)	θ value	0.000461057 (rank : 93)
Query Neighborhood Hits	351	Target Neighborhood Hits	193	Shared Neighborhood Hits	142
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.334627 (rank : 72)	θ value	0.000461057 (rank : 92)
Query Neighborhood Hits	351	Target Neighborhood Hits	193	Shared Neighborhood Hits	142
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7B_HUMAN
NC score	0.332891 (rank : 73)	θ value	0.000786445 (rank : 99)
Query Neighborhood Hits	351	Target Neighborhood Hits	200	Shared Neighborhood Hits	140
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

FARP2_MOUSE
NC score	0.332660 (rank : 74)	θ value	4.1701e-05 (rank : 68)
Query Neighborhood Hits	351	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

LIN7B_MOUSE
NC score	0.332414 (rank : 75)	θ value	0.000602161 (rank : 95)
Query Neighborhood Hits	351	Target Neighborhood Hits	200	Shared Neighborhood Hits	140
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

PDZ11_HUMAN
NC score	0.328838 (rank : 76)	θ value	0.0330416 (rank : 159)
Query Neighborhood Hits	351	Target Neighborhood Hits	160	Shared Neighborhood Hits	123
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

NHRF2_MOUSE
NC score	0.328160 (rank : 77)	θ value	0.0193708 (rank : 149)
Query Neighborhood Hits	351	Target Neighborhood Hits	194	Shared Neighborhood Hits	138
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

LIN7C_HUMAN
NC score	0.327505 (rank : 78)	θ value	0.00298849 (rank : 121)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.327505 (rank : 79)	θ value	0.00298849 (rank : 122)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	141
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

PDZ11_MOUSE
NC score	0.327494 (rank : 80)	θ value	0.0252991 (rank : 154)
Query Neighborhood Hits	351	Target Neighborhood Hits	154	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

TX1B3_HUMAN
NC score	0.316167 (rank : 81)	θ value	0.0431538 (rank : 165)
Query Neighborhood Hits	351	Target Neighborhood Hits	161	Shared Neighborhood Hits	126
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.314968 (rank : 82)	θ value	0.0431538 (rank : 166)
Query Neighborhood Hits	351	Target Neighborhood Hits	158	Shared Neighborhood Hits	124
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

ARHG7_MOUSE
NC score	0.313346 (rank : 83)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	351	Target Neighborhood Hits	396	Shared Neighborhood Hits	86
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

INADL_MOUSE
NC score	0.312310 (rank : 84)	θ value	0.00390308 (rank : 126)
Query Neighborhood Hits	351	Target Neighborhood Hits	290	Shared Neighborhood Hits	145
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

GOPC_MOUSE
NC score	0.310393 (rank : 85)	θ value	0.00869519 (rank : 139)
Query Neighborhood Hits	351	Target Neighborhood Hits	323	Shared Neighborhood Hits	158
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GOPC_HUMAN
NC score	0.309216 (rank : 86)	θ value	0.00869519 (rank : 138)
Query Neighborhood Hits	351	Target Neighborhood Hits	377	Shared Neighborhood Hits	162
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

MPDZ_MOUSE
NC score	0.308545 (rank : 87)	θ value	0.00134147 (rank : 108)
Query Neighborhood Hits	351	Target Neighborhood Hits	298	Shared Neighborhood Hits	145
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_HUMAN
NC score	0.308208 (rank : 88)	θ value	0.00228821 (rank : 118)
Query Neighborhood Hits	351	Target Neighborhood Hits	260	Shared Neighborhood Hits	143
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

PAR3L_HUMAN
NC score	0.307277 (rank : 89)	θ value	0.000121331 (rank : 78)
Query Neighborhood Hits	351	Target Neighborhood Hits	297	Shared Neighborhood Hits	127
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

MAGI1_HUMAN
NC score	0.306910 (rank : 90)	θ value	0.00035302 (rank : 88)
Query Neighborhood Hits	351	Target Neighborhood Hits	388	Shared Neighborhood Hits	154
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.305993 (rank : 91)	θ value	0.00035302 (rank : 89)
Query Neighborhood Hits	351	Target Neighborhood Hits	403	Shared Neighborhood Hits	155
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

ARHG6_HUMAN
NC score	0.305813 (rank : 92)	θ value	0.0193708 (rank : 148)
Query Neighborhood Hits	351	Target Neighborhood Hits	376	Shared Neighborhood Hits	72
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FARP1_HUMAN
NC score	0.305091 (rank : 93)	θ value	2.21117e-06 (rank : 55)
Query Neighborhood Hits	351	Target Neighborhood Hits	241	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
NC score	0.304955 (rank : 94)	θ value	7.1131e-05 (rank : 73)
Query Neighborhood Hits	351	Target Neighborhood Hits	240	Shared Neighborhood Hits	67
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MPDZ_HUMAN
NC score	0.303897 (rank : 95)	θ value	0.0148317 (rank : 146)
Query Neighborhood Hits	351	Target Neighborhood Hits	261	Shared Neighborhood Hits	149
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MAGI2_HUMAN
NC score	0.303325 (rank : 96)	θ value	4.1701e-05 (rank : 69)
Query Neighborhood Hits	351	Target Neighborhood Hits	373	Shared Neighborhood Hits	148
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SHAN2_MOUSE
NC score	0.302814 (rank : 97)	θ value	6.43352e-06 (rank : 60)
Query Neighborhood Hits	351	Target Neighborhood Hits	446	Shared Neighborhood Hits	134
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

GRIP2_HUMAN
NC score	0.302718 (rank : 98)	θ value	0.00175202 (rank : 112)
Query Neighborhood Hits	351	Target Neighborhood Hits	256	Shared Neighborhood Hits	147
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GNRP_MOUSE
NC score	0.302413 (rank : 99)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	351	Target Neighborhood Hits	191	Shared Neighborhood Hits	63
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MAGI2_MOUSE
NC score	0.300786 (rank : 100)	θ value	5.44631e-05 (rank : 71)
Query Neighborhood Hits	351	Target Neighborhood Hits	370	Shared Neighborhood Hits	145
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PARD3_HUMAN
NC score	0.298525 (rank : 101)	θ value	0.00134147 (rank : 109)
Query Neighborhood Hits	351	Target Neighborhood Hits	312	Shared Neighborhood Hits	146
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
NC score	0.297108 (rank : 102)	θ value	0.00134147 (rank : 110)
Query Neighborhood Hits	351	Target Neighborhood Hits	290	Shared Neighborhood Hits	142
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

SNTG2_HUMAN
NC score	0.297049 (rank : 103)	θ value	2.44474e-05 (rank : 66)
Query Neighborhood Hits	351	Target Neighborhood Hits	191	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

FGD5_HUMAN
NC score	0.296991 (rank : 104)	θ value	0.0431538 (rank : 163)
Query Neighborhood Hits	351	Target Neighborhood Hits	235	Shared Neighborhood Hits	48
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

GRIP1_HUMAN
NC score	0.296464 (rank : 105)	θ value	0.00228821 (rank : 117)
Query Neighborhood Hits	351	Target Neighborhood Hits	231	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
NC score	0.293995 (rank : 106)	θ value	0.00665767 (rank : 133)
Query Neighborhood Hits	351	Target Neighborhood Hits	241	Shared Neighborhood Hits	148
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

RHPN1_MOUSE
NC score	0.292072 (rank : 107)	θ value	9.92553e-07 (rank : 52)
Query Neighborhood Hits	351	Target Neighborhood Hits	154	Shared Neighborhood Hits	119
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

DLG2_HUMAN
NC score	0.290091 (rank : 108)	θ value	2.21117e-06 (rank : 54)
Query Neighborhood Hits	351	Target Neighborhood Hits	279	Shared Neighborhood Hits	145
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PDZD2_HUMAN
NC score	0.288827 (rank : 109)	θ value	0.000602161 (rank : 96)
Query Neighborhood Hits	351	Target Neighborhood Hits	772	Shared Neighborhood Hits	159
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

ARHG6_MOUSE
NC score	0.287221 (rank : 110)	θ value	0.279714 (rank : 195)
Query Neighborhood Hits	351	Target Neighborhood Hits	394	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DLG2_MOUSE
NC score	0.286858 (rank : 111)	θ value	1.87187e-05 (rank : 65)
Query Neighborhood Hits	351	Target Neighborhood Hits	271	Shared Neighborhood Hits	144
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SNTG1_HUMAN
NC score	0.286846 (rank : 112)	θ value	0.00134147 (rank : 111)
Query Neighborhood Hits	351	Target Neighborhood Hits	181	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

DLG3_MOUSE
NC score	0.284839 (rank : 113)	θ value	0.00035302 (rank : 87)
Query Neighborhood Hits	351	Target Neighborhood Hits	274	Shared Neighborhood Hits	141
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

SNTG1_MOUSE
NC score	0.284214 (rank : 114)	θ value	0.00390308 (rank : 130)
Query Neighborhood Hits	351	Target Neighborhood Hits	179	Shared Neighborhood Hits	129
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

DLG3_HUMAN
NC score	0.282592 (rank : 115)	θ value	0.000786445 (rank : 98)
Query Neighborhood Hits	351	Target Neighborhood Hits	269	Shared Neighborhood Hits	141
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG1_HUMAN
NC score	0.280882 (rank : 116)	θ value	0.000602161 (rank : 94)
Query Neighborhood Hits	351	Target Neighborhood Hits	290	Shared Neighborhood Hits	139
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
NC score	0.279888 (rank : 117)	θ value	0.000461057 (rank : 91)
Query Neighborhood Hits	351	Target Neighborhood Hits	285	Shared Neighborhood Hits	135
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

GNRP_HUMAN
NC score	0.279874 (rank : 118)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	351	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

DLG4_MOUSE
NC score	0.278076 (rank : 119)	θ value	0.00869519 (rank : 136)
Query Neighborhood Hits	351	Target Neighborhood Hits	282	Shared Neighborhood Hits	141
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.277984 (rank : 120)	θ value	0.00869519 (rank : 135)
Query Neighborhood Hits	351	Target Neighborhood Hits	286	Shared Neighborhood Hits	139
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

SNTB2_MOUSE
NC score	0.276417 (rank : 121)	θ value	0.00102713 (rank : 105)
Query Neighborhood Hits	351	Target Neighborhood Hits	181	Shared Neighborhood Hits	121
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

FGD5_MOUSE
NC score	0.275147 (rank : 122)	θ value	0.0330416 (rank : 157)
Query Neighborhood Hits	351	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

SNTB2_HUMAN
NC score	0.274336 (rank : 123)	θ value	0.00228821 (rank : 120)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	121
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

LNX2_MOUSE
NC score	0.274306 (rank : 124)	θ value	0.00390308 (rank : 128)
Query Neighborhood Hits	351	Target Neighborhood Hits	407	Shared Neighborhood Hits	140
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

RHPN1_HUMAN
NC score	0.272990 (rank : 125)	θ value	1.29631e-06 (rank : 53)
Query Neighborhood Hits	351	Target Neighborhood Hits	158	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SNTG2_MOUSE
NC score	0.271085 (rank : 126)	θ value	0.0193708 (rank : 151)
Query Neighborhood Hits	351	Target Neighborhood Hits	176	Shared Neighborhood Hits	125
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

LNX1_MOUSE
NC score	0.270907 (rank : 127)	θ value	0.00390308 (rank : 127)
Query Neighborhood Hits	351	Target Neighborhood Hits	377	Shared Neighborhood Hits	137
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
NC score	0.270893 (rank : 128)	θ value	0.00665767 (rank : 134)
Query Neighborhood Hits	351	Target Neighborhood Hits	389	Shared Neighborhood Hits	140
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

SHAN2_HUMAN
NC score	0.269844 (rank : 129)	θ value	2.88788e-06 (rank : 58)
Query Neighborhood Hits	351	Target Neighborhood Hits	346	Shared Neighborhood Hits	117
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

LNX1_HUMAN
NC score	0.267934 (rank : 130)	θ value	0.00298849 (rank : 123)
Query Neighborhood Hits	351	Target Neighborhood Hits	379	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

ZO3_MOUSE
NC score	0.259305 (rank : 131)	θ value	0.21417 (rank : 194)
Query Neighborhood Hits	351	Target Neighborhood Hits	224	Shared Neighborhood Hits	138
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SNTA1_HUMAN
NC score	0.258609 (rank : 132)	θ value	0.0736092 (rank : 173)
Query Neighborhood Hits	351	Target Neighborhood Hits	186	Shared Neighborhood Hits	126
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

PSCBP_MOUSE
NC score	0.257758 (rank : 133)	θ value	0.00869519 (rank : 141)
Query Neighborhood Hits	351	Target Neighborhood Hits	118	Shared Neighborhood Hits	104
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

GRASP_HUMAN
NC score	0.256852 (rank : 134)	θ value	0.0563607 (rank : 168)
Query Neighborhood Hits	351	Target Neighborhood Hits	147	Shared Neighborhood Hits	109
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

ZO3_HUMAN
NC score	0.254494 (rank : 135)	θ value	0.0961366 (rank : 180)
Query Neighborhood Hits	351	Target Neighborhood Hits	219	Shared Neighborhood Hits	135
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO1_MOUSE
NC score	0.253455 (rank : 136)	θ value	5.44631e-05 (rank : 72)
Query Neighborhood Hits	351	Target Neighborhood Hits	453	Shared Neighborhood Hits	143
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTA1_MOUSE
NC score	0.252772 (rank : 137)	θ value	0.125558 (rank : 185)
Query Neighborhood Hits	351	Target Neighborhood Hits	170	Shared Neighborhood Hits	123
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

GRASP_MOUSE
NC score	0.251436 (rank : 138)	θ value	0.125558 (rank : 182)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	109
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

ZO2_HUMAN
NC score	0.249513 (rank : 139)	θ value	0.0148317 (rank : 147)
Query Neighborhood Hits	351	Target Neighborhood Hits	289	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PKHG4_HUMAN
NC score	0.247577 (rank : 140)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	351	Target Neighborhood Hits	200	Shared Neighborhood Hits	57
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZO2_MOUSE
NC score	0.247379 (rank : 141)	θ value	0.00869519 (rank : 142)
Query Neighborhood Hits	351	Target Neighborhood Hits	296	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

SDCB1_MOUSE
NC score	0.246672 (rank : 142)	θ value	0.000786445 (rank : 102)
Query Neighborhood Hits	351	Target Neighborhood Hits	144	Shared Neighborhood Hits	121
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

ZO1_HUMAN
NC score	0.244369 (rank : 143)	θ value	0.00175202 (rank : 116)
Query Neighborhood Hits	351	Target Neighborhood Hits	474	Shared Neighborhood Hits	141
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SDCB1_HUMAN
NC score	0.243901 (rank : 144)	θ value	0.000786445 (rank : 101)
Query Neighborhood Hits	351	Target Neighborhood Hits	150	Shared Neighborhood Hits	127
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SNTB1_MOUSE
NC score	0.238035 (rank : 145)	θ value	0.163984 (rank : 187)
Query Neighborhood Hits	351	Target Neighborhood Hits	160	Shared Neighborhood Hits	113
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB1_HUMAN
NC score	0.237651 (rank : 146)	θ value	0.21417 (rank : 192)
Query Neighborhood Hits	351	Target Neighborhood Hits	157	Shared Neighborhood Hits	113
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

PSCBP_HUMAN
NC score	0.236023 (rank : 147)	θ value	0.0961366 (rank : 178)
Query Neighborhood Hits	351	Target Neighborhood Hits	123	Shared Neighborhood Hits	101
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PZRN3_MOUSE
NC score	0.232745 (rank : 148)	θ value	0.00390308 (rank : 129)
Query Neighborhood Hits	351	Target Neighborhood Hits	447	Shared Neighborhood Hits	130
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
NC score	0.231037 (rank : 149)	θ value	0.0961366 (rank : 179)
Query Neighborhood Hits	351	Target Neighborhood Hits	438	Shared Neighborhood Hits	129
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LAP4_HUMAN
NC score	0.230238 (rank : 150)	θ value	5.81887e-07 (rank : 49)
Query Neighborhood Hits	351	Target Neighborhood Hits	608	Shared Neighborhood Hits	156
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PZRN3_HUMAN
NC score	0.230060 (rank : 151)	θ value	0.00509761 (rank : 131)
Query Neighborhood Hits	351	Target Neighborhood Hits	461	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

IL16_HUMAN
NC score	0.225293 (rank : 152)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	351	Target Neighborhood Hits	207	Shared Neighborhood Hits	110
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SYP2L_HUMAN
NC score	0.224023 (rank : 153)	θ value	0.00035302 (rank : 90)
Query Neighborhood Hits	351	Target Neighborhood Hits	400	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

BCR_HUMAN
NC score	0.222041 (rank : 154)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	351	Target Neighborhood Hits	204	Shared Neighborhood Hits	59
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

LAP4_MOUSE
NC score	0.220802 (rank : 155)	θ value	1.43324e-05 (rank : 64)
Query Neighborhood Hits	351	Target Neighborhood Hits	590	Shared Neighborhood Hits	153
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

ABR_HUMAN
NC score	0.213357 (rank : 156)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	351	Target Neighborhood Hits	166	Shared Neighborhood Hits	59
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

APBA1_HUMAN
NC score	0.212307 (rank : 157)	θ value	0.0252991 (rank : 152)
Query Neighborhood Hits	351	Target Neighborhood Hits	325	Shared Neighborhood Hits	124
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

IL16_MOUSE
NC score	0.211551 (rank : 158)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	351	Target Neighborhood Hits	189	Shared Neighborhood Hits	102
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

RPGF6_HUMAN
NC score	0.210367 (rank : 159)	θ value	0.00298849 (rank : 125)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	131
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SHAN1_HUMAN
NC score	0.207374 (rank : 160)	θ value	1.99992e-07 (rank : 46)
Query Neighborhood Hits	351	Target Neighborhood Hits	1041	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

APBA2_HUMAN
NC score	0.206039 (rank : 161)	θ value	0.0431538 (rank : 160)
Query Neighborhood Hits	351	Target Neighborhood Hits	220	Shared Neighborhood Hits	119
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
NC score	0.206029 (rank : 162)	θ value	0.0431538 (rank : 161)
Query Neighborhood Hits	351	Target Neighborhood Hits	219	Shared Neighborhood Hits	122
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
NC score	0.204319 (rank : 163)	θ value	0.47712 (rank : 204)
Query Neighborhood Hits	351	Target Neighborhood Hits	201	Shared Neighborhood Hits	116
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

NEB1_HUMAN
NC score	0.201204 (rank : 164)	θ value	0.0113563 (rank : 144)
Query Neighborhood Hits	351	Target Neighborhood Hits	829	Shared Neighborhood Hits	163
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

APBA3_MOUSE
NC score	0.199490 (rank : 165)	θ value	0.125558 (rank : 181)
Query Neighborhood Hits	351	Target Neighborhood Hits	174	Shared Neighborhood Hits	111
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

AFAD_HUMAN
NC score	0.197988 (rank : 166)	θ value	5.27518 (rank : 288)
Query Neighborhood Hits	351	Target Neighborhood Hits	689	Shared Neighborhood Hits	164
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

DLG5_HUMAN
NC score	0.197659 (rank : 167)	θ value	5.27518 (rank : 295)
Query Neighborhood Hits	351	Target Neighborhood Hits	1088	Shared Neighborhood Hits	196
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

PTN13_HUMAN
NC score	0.196806 (rank : 168)	θ value	2.88788e-06 (rank : 57)
Query Neighborhood Hits	351	Target Neighborhood Hits	471	Shared Neighborhood Hits	146
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

NEB2_HUMAN
NC score	0.193430 (rank : 169)	θ value	0.0961366 (rank : 176)
Query Neighborhood Hits	351	Target Neighborhood Hits	883	Shared Neighborhood Hits	161
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.192153 (rank : 170)	θ value	0.0961366 (rank : 177)
Query Neighborhood Hits	351	Target Neighborhood Hits	889	Shared Neighborhood Hits	163
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PDLI2_HUMAN
NC score	0.192090 (rank : 171)	θ value	0.62314 (rank : 212)
Query Neighborhood Hits	351	Target Neighborhood Hits	245	Shared Neighborhood Hits	115
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
NC score	0.192005 (rank : 172)	θ value	0.365318 (rank : 201)
Query Neighborhood Hits	351	Target Neighborhood Hits	220	Shared Neighborhood Hits	110
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PTN13_MOUSE
NC score	0.191748 (rank : 173)	θ value	0.00020696 (rank : 81)
Query Neighborhood Hits	351	Target Neighborhood Hits	426	Shared Neighborhood Hits	149
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RPGF2_HUMAN
NC score	0.187678 (rank : 174)	θ value	0.0252991 (rank : 155)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RGS12_HUMAN
NC score	0.186210 (rank : 175)	θ value	0.00102713 (rank : 104)
Query Neighborhood Hits	351	Target Neighborhood Hits	333	Shared Neighborhood Hits	116
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

K1849_HUMAN
NC score	0.185803 (rank : 176)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	351	Target Neighborhood Hits	220	Shared Neighborhood Hits	117
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

SDCB2_MOUSE
NC score	0.180585 (rank : 177)	θ value	2.36792 (rank : 251)
Query Neighborhood Hits	351	Target Neighborhood Hits	118	Shared Neighborhood Hits	101
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SYP2L_MOUSE
NC score	0.179085 (rank : 178)	θ value	0.0252991 (rank : 156)
Query Neighborhood Hits	351	Target Neighborhood Hits	289	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

K1849_MOUSE
NC score	0.178320 (rank : 179)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	351	Target Neighborhood Hits	335	Shared Neighborhood Hits	123
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

SDCB2_HUMAN
NC score	0.174140 (rank : 180)	θ value	5.27518 (rank : 311)
Query Neighborhood Hits	351	Target Neighborhood Hits	121	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SYNP2_MOUSE
NC score	0.171246 (rank : 181)	θ value	0.21417 (rank : 193)
Query Neighborhood Hits	351	Target Neighborhood Hits	252	Shared Neighborhood Hits	107
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

MPP4_HUMAN
NC score	0.166006 (rank : 182)	θ value	2.36792 (rank : 247)
Query Neighborhood Hits	351	Target Neighborhood Hits	205	Shared Neighborhood Hits	109
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP3_MOUSE
NC score	0.163066 (rank : 183)	θ value	0.0961366 (rank : 175)
Query Neighborhood Hits	351	Target Neighborhood Hits	165	Shared Neighborhood Hits	103
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP3_HUMAN
NC score	0.160882 (rank : 184)	θ value	0.125558 (rank : 184)
Query Neighborhood Hits	351	Target Neighborhood Hits	171	Shared Neighborhood Hits	103
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

DUET_HUMAN
NC score	0.160726 (rank : 185)	θ value	5.26297e-08 (rank : 45)
Query Neighborhood Hits	351	Target Neighborhood Hits	1220	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.156016 (rank : 186)	θ value	7.59969e-07 (rank : 50)
Query Neighborhood Hits	351	Target Neighborhood Hits	1580	Shared Neighborhood Hits	128
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PDZK4_HUMAN
NC score	0.152924 (rank : 187)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	351	Target Neighborhood Hits	165	Shared Neighborhood Hits	98
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

MPP5_HUMAN
NC score	0.152899 (rank : 188)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	351	Target Neighborhood Hits	231	Shared Neighborhood Hits	104
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PDZK4_MOUSE
NC score	0.152179 (rank : 189)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	351	Target Neighborhood Hits	165	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

MPP5_MOUSE
NC score	0.151664 (rank : 190)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	351	Target Neighborhood Hits	226	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

PICK1_HUMAN
NC score	0.150812 (rank : 191)	θ value	6.88961 (rank : 324)
Query Neighborhood Hits	351	Target Neighborhood Hits	132	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
NC score	0.150364 (rank : 192)	θ value	6.88961 (rank : 325)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

MPP4_MOUSE
NC score	0.146584 (rank : 193)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	351	Target Neighborhood Hits	188	Shared Neighborhood Hits	100
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

SOS1_HUMAN
NC score	0.144084 (rank : 194)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	351	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
NC score	0.143154 (rank : 195)	θ value	0.279714 (rank : 199)
Query Neighborhood Hits	351	Target Neighborhood Hits	193	Shared Neighborhood Hits	46
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

EM55_HUMAN
NC score	0.142380 (rank : 196)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	351	Target Neighborhood Hits	228	Shared Neighborhood Hits	107
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

STXB4_HUMAN
NC score	0.140744 (rank : 197)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	351	Target Neighborhood Hits	616	Shared Neighborhood Hits	136
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

EM55_MOUSE
NC score	0.140514 (rank : 198)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	351	Target Neighborhood Hits	221	Shared Neighborhood Hits	106
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

NCF1_HUMAN
NC score	0.139191 (rank : 199)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SYNP2_HUMAN
NC score	0.138367 (rank : 200)	θ value	3.0926 (rank : 266)
Query Neighborhood Hits	351	Target Neighborhood Hits	323	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SH3K1_HUMAN
NC score	0.137133 (rank : 201)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	351	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SOS1_MOUSE
NC score	0.136235 (rank : 202)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	351	Target Neighborhood Hits	281	Shared Neighborhood Hits	50
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

STXB4_MOUSE
NC score	0.133626 (rank : 203)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	351	Target Neighborhood Hits	629	Shared Neighborhood Hits	127
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

CD2AP_HUMAN
NC score	0.132179 (rank : 204)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	351	Target Neighborhood Hits	315	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.131319 (rank : 205)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	351	Target Neighborhood Hits	336	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PDZD8_HUMAN
NC score	0.130443 (rank : 206)	θ value	0.0736092 (rank : 172)
Query Neighborhood Hits	351	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

NCF1_MOUSE
NC score	0.129391 (rank : 207)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

APXL_HUMAN
NC score	0.128240 (rank : 208)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	351	Target Neighborhood Hits	553	Shared Neighborhood Hits	108
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

LRRC7_HUMAN
NC score	0.127412 (rank : 209)	θ value	0.00175202 (rank : 113)
Query Neighborhood Hits	351	Target Neighborhood Hits	423	Shared Neighborhood Hits	98
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.126962 (rank : 210)	θ value	0.00175202 (rank : 114)
Query Neighborhood Hits	351	Target Neighborhood Hits	416	Shared Neighborhood Hits	100
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

SH3K1_MOUSE
NC score	0.126368 (rank : 211)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	351	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

PAR6G_HUMAN
NC score	0.122552 (rank : 212)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	351	Target Neighborhood Hits	159	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

NCF2_HUMAN
NC score	0.121335 (rank : 213)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	351	Target Neighborhood Hits	229	Shared Neighborhood Hits	34
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PAR6B_HUMAN
NC score	0.121124 (rank : 214)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	351	Target Neighborhood Hits	126	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

SRBS1_MOUSE
NC score	0.120757 (rank : 215)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	351	Target Neighborhood Hits	409	Shared Neighborhood Hits	37
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

LMO7_HUMAN
NC score	0.120395 (rank : 216)	θ value	1.06291 (rank : 222)
Query Neighborhood Hits	351	Target Neighborhood Hits	507	Shared Neighborhood Hits	94
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

PAR6G_MOUSE
NC score	0.120331 (rank : 217)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	351	Target Neighborhood Hits	121	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP6_MOUSE
NC score	0.120319 (rank : 218)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	351	Target Neighborhood Hits	187	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PAR6B_MOUSE
NC score	0.120289 (rank : 219)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	351	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

NCK1_HUMAN
NC score	0.119379 (rank : 220)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	351	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

MPP6_HUMAN
NC score	0.119322 (rank : 221)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

DVL3_MOUSE
NC score	0.118826 (rank : 222)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	351	Target Neighborhood Hits	198	Shared Neighborhood Hits	89
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_HUMAN
NC score	0.118679 (rank : 223)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	351	Target Neighborhood Hits	158	Shared Neighborhood Hits	92
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_HUMAN
NC score	0.118585 (rank : 224)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	351	Target Neighborhood Hits	194	Shared Neighborhood Hits	87
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PDLI5_HUMAN
NC score	0.116966 (rank : 225)	θ value	0.0563607 (rank : 170)
Query Neighborhood Hits	351	Target Neighborhood Hits	322	Shared Neighborhood Hits	103
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

SRBS1_HUMAN
NC score	0.116863 (rank : 226)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	351	Target Neighborhood Hits	396	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DVL1_MOUSE
NC score	0.116508 (rank : 227)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	351	Target Neighborhood Hits	146	Shared Neighborhood Hits	90
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

NOS1_HUMAN
NC score	0.116181 (rank : 228)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	351	Target Neighborhood Hits	218	Shared Neighborhood Hits	108
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDLI3_HUMAN
NC score	0.116131 (rank : 229)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	351	Target Neighborhood Hits	199	Shared Neighborhood Hits	93
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PAR6A_MOUSE
NC score	0.115831 (rank : 230)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	351	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.115250 (rank : 231)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	351	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PDLI5_MOUSE
NC score	0.114899 (rank : 232)	θ value	0.0193708 (rank : 150)
Query Neighborhood Hits	351	Target Neighborhood Hits	287	Shared Neighborhood Hits	102
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI4_MOUSE
NC score	0.114453 (rank : 233)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	351	Target Neighborhood Hits	233	Shared Neighborhood Hits	99
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

LDB3_HUMAN
NC score	0.114382 (rank : 234)	θ value	0.0252991 (rank : 153)
Query Neighborhood Hits	351	Target Neighborhood Hits	497	Shared Neighborhood Hits	97
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

GRAP_HUMAN
NC score	0.114103 (rank : 235)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	36
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

LDB3_MOUSE
NC score	0.113420 (rank : 236)	θ value	0.21417 (rank : 190)
Query Neighborhood Hits	351	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

VINEX_MOUSE
NC score	0.113296 (rank : 237)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	351	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

PKHF2_HUMAN
NC score	0.113264 (rank : 238)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	351	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

GRAP_MOUSE
NC score	0.113209 (rank : 239)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	351	Target Neighborhood Hits	309	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VINEX_HUMAN
NC score	0.112668 (rank : 240)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	351	Target Neighborhood Hits	270	Shared Neighborhood Hits	32
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PKHF2_MOUSE
NC score	0.112615 (rank : 241)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	351	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PDLI4_HUMAN
NC score	0.112039 (rank : 242)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	351	Target Neighborhood Hits	245	Shared Neighborhood Hits	98
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

MPP2_MOUSE
NC score	0.111854 (rank : 243)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	351	Target Neighborhood Hits	189	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

PDLI1_MOUSE
NC score	0.111545 (rank : 244)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	351	Target Neighborhood Hits	213	Shared Neighborhood Hits	91
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

DVL2_MOUSE
NC score	0.111493 (rank : 245)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	351	Target Neighborhood Hits	233	Shared Neighborhood Hits	92
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

MPP2_HUMAN
NC score	0.111475 (rank : 246)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	351	Target Neighborhood Hits	173	Shared Neighborhood Hits	84
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

NCK2_HUMAN
NC score	0.111448 (rank : 247)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	351	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PDLI1_HUMAN
NC score	0.111358 (rank : 248)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	89
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RHPN2_MOUSE
NC score	0.111197 (rank : 249)	θ value	0.21417 (rank : 191)
Query Neighborhood Hits	351	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

DVL2_HUMAN
NC score	0.111171 (rank : 250)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	351	Target Neighborhood Hits	223	Shared Neighborhood Hits	92
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL1L_HUMAN
NC score	0.110369 (rank : 251)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	351	Target Neighborhood Hits	146	Shared Neighborhood Hits	89
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

PDLI3_MOUSE
NC score	0.109136 (rank : 252)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	89
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

GRB2_MOUSE
NC score	0.108108 (rank : 253)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	351	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.108039 (rank : 254)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	351	Target Neighborhood Hits	310	Shared Neighborhood Hits	37
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

LAP2_HUMAN
NC score	0.107241 (rank : 255)	θ value	0.62314 (rank : 209)
Query Neighborhood Hits	351	Target Neighborhood Hits	499	Shared Neighborhood Hits	96
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PKHF1_HUMAN
NC score	0.106058 (rank : 256)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	351	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.105131 (rank : 257)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	351	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

STAM1_MOUSE
NC score	0.105056 (rank : 258)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	351	Target Neighborhood Hits	273	Shared Neighborhood Hits	37
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GIPC1_MOUSE
NC score	0.103909 (rank : 259)	θ value	3.0926 (rank : 259)
Query Neighborhood Hits	351	Target Neighborhood Hits	92	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

RGS3_HUMAN
NC score	0.103647 (rank : 260)	θ value	9.29e-05 (rank : 76)
Query Neighborhood Hits	351	Target Neighborhood Hits	1375	Shared Neighborhood Hits	94
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

LAP2_MOUSE
NC score	0.103569 (rank : 261)	θ value	0.62314 (rank : 210)
Query Neighborhood Hits	351	Target Neighborhood Hits	482	Shared Neighborhood Hits	96
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

STAC_HUMAN
NC score	0.103391 (rank : 262)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	351	Target Neighborhood Hits	276	Shared Neighborhood Hits	29
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
NC score	0.102342 (rank : 263)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	351	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
NC score	0.102321 (rank : 264)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	351	Target Neighborhood Hits	271	Shared Neighborhood Hits	38
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GIPC1_HUMAN
NC score	0.101057 (rank : 265)	θ value	2.36792 (rank : 243)
Query Neighborhood Hits	351	Target Neighborhood Hits	91	Shared Neighborhood Hits	69
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

PDLI7_HUMAN
NC score	0.099287 (rank : 266)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	351	Target Neighborhood Hits	547	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

RGS3_MOUSE
NC score	0.098349 (rank : 267)	θ value	3.19293e-05 (rank : 67)
Query Neighborhood Hits	351	Target Neighborhood Hits	1621	Shared Neighborhood Hits	109
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

STAM2_MOUSE
NC score	0.097825 (rank : 268)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	351	Target Neighborhood Hits	285	Shared Neighborhood Hits	38
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.096685 (rank : 269)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	351	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRKL_HUMAN
NC score	0.096438 (rank : 270)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	351	Target Neighborhood Hits	313	Shared Neighborhood Hits	34
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NCF4_HUMAN
NC score	0.095316 (rank : 271)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	351	Target Neighborhood Hits	161	Shared Neighborhood Hits	18
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.094714 (rank : 272)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	351	Target Neighborhood Hits	177	Shared Neighborhood Hits	20
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_HUMAN
NC score	0.094602 (rank : 273)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	351	Target Neighborhood Hits	350	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CRKL_MOUSE
NC score	0.093875 (rank : 274)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PDLI7_MOUSE
NC score	0.093287 (rank : 275)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	351	Target Neighborhood Hits	279	Shared Neighborhood Hits	90
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GIPC2_HUMAN
NC score	0.092527 (rank : 276)	θ value	1.81305 (rank : 238)
Query Neighborhood Hits	351	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

ABI2_MOUSE
NC score	0.092144 (rank : 277)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HCLS1_MOUSE
NC score	0.090838 (rank : 278)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	351	Target Neighborhood Hits	329	Shared Neighborhood Hits	35
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CRK_MOUSE
NC score	0.090759 (rank : 279)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	351	Target Neighborhood Hits	314	Shared Neighborhood Hits	35
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_MOUSE
NC score	0.090109 (rank : 280)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	351	Target Neighborhood Hits	246	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HCLS1_HUMAN
NC score	0.090046 (rank : 281)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	351	Target Neighborhood Hits	358	Shared Neighborhood Hits	31
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NOS1_MOUSE
NC score	0.089992 (rank : 282)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	351	Target Neighborhood Hits	155	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

STAC3_MOUSE
NC score	0.089346 (rank : 283)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	351	Target Neighborhood Hits	232	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRAP2_HUMAN
NC score	0.089161 (rank : 284)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	351	Target Neighborhood Hits	304	Shared Neighborhood Hits	33
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PCLO_MOUSE
NC score	0.088938 (rank : 285)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	351	Target Neighborhood Hits	2275	Shared Neighborhood Hits	169
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CRK_HUMAN
NC score	0.088436 (rank : 286)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	351	Target Neighborhood Hits	308	Shared Neighborhood Hits	34
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SRC8_MOUSE
NC score	0.088293 (rank : 287)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	351	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.088242 (rank : 288)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	351	Target Neighborhood Hits	269	Shared Neighborhood Hits	32
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

RIMS1_HUMAN
NC score	0.088108 (rank : 289)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	351	Target Neighborhood Hits	437	Shared Neighborhood Hits	106
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

PPIP1_HUMAN
NC score	0.087991 (rank : 290)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	351	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP2_MOUSE
NC score	0.087955 (rank : 291)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	351	Target Neighborhood Hits	297	Shared Neighborhood Hits	28
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC3_HUMAN
NC score	0.087797 (rank : 292)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	351	Target Neighborhood Hits	228	Shared Neighborhood Hits	24
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

BI2L1_HUMAN
NC score	0.086592 (rank : 293)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	351	Target Neighborhood Hits	156	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PTN3_HUMAN
NC score	0.086510 (rank : 294)	θ value	0.62314 (rank : 213)
Query Neighborhood Hits	351	Target Neighborhood Hits	258	Shared Neighborhood Hits	109
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PPIP1_MOUSE
NC score	0.085866 (rank : 295)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	351	Target Neighborhood Hits	377	Shared Neighborhood Hits	59
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

HTRA3_MOUSE
NC score	0.085301 (rank : 296)	θ value	0.125558 (rank : 183)
Query Neighborhood Hits	351	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA3_HUMAN
NC score	0.085006 (rank : 297)	θ value	0.0563607 (rank : 169)
Query Neighborhood Hits	351	Target Neighborhood Hits	152	Shared Neighborhood Hits	56
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

PTN4_HUMAN
NC score	0.084240 (rank : 298)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	351	Target Neighborhood Hits	303	Shared Neighborhood Hits	108
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

ABI1_HUMAN
NC score	0.083730 (rank : 299)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	351	Target Neighborhood Hits	257	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PLCG1_MOUSE
NC score	0.082030 (rank : 300)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	351	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MY18A_MOUSE
NC score	0.080669 (rank : 301)	θ value	1.06291 (rank : 224)
Query Neighborhood Hits	351	Target Neighborhood Hits	1989	Shared Neighborhood Hits	195
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SH3G3_MOUSE
NC score	0.080625 (rank : 302)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	351	Target Neighborhood Hits	236	Shared Neighborhood Hits	30
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PLCG1_HUMAN
NC score	0.080287 (rank : 303)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	351	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G1_HUMAN
NC score	0.079517 (rank : 304)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
NC score	0.078325 (rank : 305)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	351	Target Neighborhood Hits	324	Shared Neighborhood Hits	46
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

REPS2_MOUSE
NC score	0.078217 (rank : 306)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	351	Target Neighborhood Hits	102	Shared Neighborhood Hits	12
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SH3G3_HUMAN
NC score	0.077998 (rank : 307)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	351	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

MY18A_HUMAN
NC score	0.077959 (rank : 308)	θ value	2.36792 (rank : 248)
Query Neighborhood Hits	351	Target Neighborhood Hits	1929	Shared Neighborhood Hits	195
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NPHP1_MOUSE
NC score	0.077526 (rank : 309)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	351	Target Neighborhood Hits	267	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ABI3_HUMAN
NC score	0.077163 (rank : 310)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	351	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G1_MOUSE
NC score	0.077122 (rank : 311)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	351	Target Neighborhood Hits	291	Shared Neighborhood Hits	44
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
NC score	0.076369 (rank : 312)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	351	Target Neighborhood Hits	319	Shared Neighborhood Hits	44
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

NOXO1_MOUSE
NC score	0.076369 (rank : 313)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	351	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

EVPL_HUMAN
NC score	0.075417 (rank : 314)	θ value	0.0431538 (rank : 162)
Query Neighborhood Hits	351	Target Neighborhood Hits	895	Shared Neighborhood Hits	83
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

REPS2_HUMAN
NC score	0.074624 (rank : 315)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

EP15R_MOUSE
NC score	0.073126 (rank : 316)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	351	Target Neighborhood Hits	1135	Shared Neighborhood Hits	92
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

BI2L1_MOUSE
NC score	0.072879 (rank : 317)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CAR11_HUMAN
NC score	0.072570 (rank : 318)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	351	Target Neighborhood Hits	690	Shared Neighborhood Hits	99
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

NOXO1_HUMAN
NC score	0.072569 (rank : 319)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	351	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

AHI1_HUMAN
NC score	0.072026 (rank : 320)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	351	Target Neighborhood Hits	537	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ABI3_MOUSE
NC score	0.071871 (rank : 321)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	351	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DBNL_HUMAN
NC score	0.071812 (rank : 322)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	351	Target Neighborhood Hits	244	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

OSTF1_HUMAN
NC score	0.071280 (rank : 323)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	351	Target Neighborhood Hits	466	Shared Neighborhood Hits	37
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

RHPN2_HUMAN
NC score	0.071086 (rank : 324)	θ value	6.88961 (rank : 326)
Query Neighborhood Hits	351	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IUC4, Q8N3T7, Q8N9D6, Q8NE33, Q96RU1	Gene names	RHPN2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2) (76 kDa RhoB effector protein) (p76RBE).

ZFY28_HUMAN
NC score	0.070404 (rank : 325)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	351	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

NEBL_HUMAN
NC score	0.070367 (rank : 326)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	351	Target Neighborhood Hits	457	Shared Neighborhood Hits	66
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

AHI1_MOUSE
NC score	0.070077 (rank : 327)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	351	Target Neighborhood Hits	496	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

PLCG2_HUMAN
NC score	0.069885 (rank : 328)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	351	Target Neighborhood Hits	280	Shared Neighborhood Hits	18
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ZFYV9_HUMAN
NC score	0.069573 (rank : 329)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	351	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

OSTF1_MOUSE
NC score	0.069319 (rank : 330)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	351	Target Neighborhood Hits	467	Shared Neighborhood Hits	36
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

LASP1_HUMAN
NC score	0.069166 (rank : 331)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	351	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

EP15R_HUMAN
NC score	0.068922 (rank : 332)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	351	Target Neighborhood Hits	1083	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15_MOUSE
NC score	0.068548 (rank : 333)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	351	Target Neighborhood Hits	820	Shared Neighborhood Hits	72
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

F107B_HUMAN
NC score	0.068493 (rank : 334)	θ value	2.36792 (rank : 242)
Query Neighborhood Hits	351	Target Neighborhood Hits	120	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H098	Gene names	FAM107B, C10orf45
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

KGUA_MOUSE
NC score	0.068486 (rank : 335)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	351	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

RIMB1_HUMAN
NC score	0.068472 (rank : 336)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	351	Target Neighborhood Hits	1479	Shared Neighborhood Hits	122
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

EP15_HUMAN
NC score	0.068420 (rank : 337)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	351	Target Neighborhood Hits	1021	Shared Neighborhood Hits	87
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

CP250_HUMAN
NC score	0.068398 (rank : 338)	θ value	0.21417 (rank : 188)
Query Neighborhood Hits	351	Target Neighborhood Hits	1805	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

KGUA_HUMAN
NC score	0.068135 (rank : 339)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	351	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

DBNL_MOUSE
NC score	0.068128 (rank : 340)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	351	Target Neighborhood Hits	306	Shared Neighborhood Hits	33
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EVPL_MOUSE
NC score	0.068004 (rank : 341)	θ value	0.0563607 (rank : 167)
Query Neighborhood Hits	351	Target Neighborhood Hits	952	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

SPTA2_HUMAN
NC score	0.067670 (rank : 342)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	351	Target Neighborhood Hits	888	Shared Neighborhood Hits	91
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

CP250_MOUSE
NC score	0.067007 (rank : 343)	θ value	0.163984 (rank : 186)
Query Neighborhood Hits	351	Target Neighborhood Hits	1583	Shared Neighborhood Hits	104
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

LASP1_MOUSE
NC score	0.066969 (rank : 344)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	351	Target Neighborhood Hits	297	Shared Neighborhood Hits	26
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

HGS_MOUSE
NC score	0.066731 (rank : 345)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	351	Target Neighborhood Hits	589	Shared Neighborhood Hits	58
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RUFY2_HUMAN
NC score	0.066557 (rank : 346)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	351	Target Neighborhood Hits	1208	Shared Neighborhood Hits	104
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PACN2_MOUSE
NC score	0.066437 (rank : 347)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	351	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

GIPC3_HUMAN
NC score	0.066276 (rank : 348)	θ value	3.0926 (rank : 260)
Query Neighborhood Hits	351	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

ZFY16_MOUSE
NC score	0.065988 (rank : 349)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	351	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

RIMS2_HUMAN
NC score	0.065971 (rank : 350)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	351	Target Neighborhood Hits	342	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
NC score	0.065636 (rank : 351)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	351	Target Neighborhood Hits	376	Shared Neighborhood Hits	91
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

PACN3_HUMAN
NC score	0.065600 (rank : 352)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	351	Target Neighborhood Hits	385	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

GIPC3_MOUSE
NC score	0.065370 (rank : 353)	θ value	3.0926 (rank : 261)
Query Neighborhood Hits	351	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

F107B_MOUSE
NC score	0.065231 (rank : 354)	θ value	3.0926 (rank : 258)
Query Neighborhood Hits	351	Target Neighborhood Hits	126	Shared Neighborhood Hits	29
SwissProt Accessions	Q3TGF2	Gene names	Fam107b
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

PCNT_MOUSE
NC score	0.065202 (rank : 355)	θ value	0.279714 (rank : 198)
Query Neighborhood Hits	351	Target Neighborhood Hits	1207	Shared Neighborhood Hits	103
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PACN1_HUMAN
NC score	0.065102 (rank : 356)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	351	Target Neighborhood Hits	320	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EEA1_HUMAN
NC score	0.065058 (rank : 357)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	351	Target Neighborhood Hits	1796	Shared Neighborhood Hits	116
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

CNKR2_MOUSE
NC score	0.064840 (rank : 358)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ZFY16_HUMAN
NC score	0.064810 (rank : 359)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	351	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

CNKR2_HUMAN
NC score	0.064731 (rank : 360)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	351	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GOGA3_MOUSE
NC score	0.064724 (rank : 361)	θ value	0.0736092 (rank : 171)
Query Neighborhood Hits	351	Target Neighborhood Hits	1437	Shared Neighborhood Hits	108
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

EEA1_MOUSE
NC score	0.064383 (rank : 362)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	351	Target Neighborhood Hits	1637	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PACN3_MOUSE
NC score	0.064000 (rank : 363)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	351	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

HGS_HUMAN
NC score	0.063993 (rank : 364)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	351	Target Neighborhood Hits	517	Shared Neighborhood Hits	51
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ANM2_HUMAN
NC score	0.063778 (rank : 365)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	351	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

REPS1_MOUSE
NC score	0.063777 (rank : 366)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	351	Target Neighborhood Hits	204	Shared Neighborhood Hits	16
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

ZFY21_MOUSE
NC score	0.063476 (rank : 367)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	351	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

RIMB1_MOUSE
NC score	0.063280 (rank : 368)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	351	Target Neighborhood Hits	1376	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

NPHP1_HUMAN
NC score	0.063262 (rank : 369)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	351	Target Neighborhood Hits	288	Shared Neighborhood Hits	35
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

BAIP2_MOUSE
NC score	0.063192 (rank : 370)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	351	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

GIPC2_MOUSE
NC score	0.062813 (rank : 371)	θ value	5.27518 (rank : 298)
Query Neighborhood Hits	351	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

BCAR1_MOUSE
NC score	0.062657 (rank : 372)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	351	Target Neighborhood Hits	438	Shared Neighborhood Hits	40
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BAIP2_HUMAN
NC score	0.062467 (rank : 373)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	351	Target Neighborhood Hits	192	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BCAR1_HUMAN
NC score	0.062419 (rank : 374)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	351	Target Neighborhood Hits	554	Shared Neighborhood Hits	43
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PACN2_HUMAN
NC score	0.062385 (rank : 375)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	351	Target Neighborhood Hits	339	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.062319 (rank : 376)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	351	Target Neighborhood Hits	283	Shared Neighborhood Hits	36
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

TCGAP_MOUSE
NC score	0.062048 (rank : 377)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	351	Target Neighborhood Hits	409	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RUFY1_HUMAN
NC score	0.061931 (rank : 378)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	351	Target Neighborhood Hits	848	Shared Neighborhood Hits	90
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

REPS1_HUMAN
NC score	0.061666 (rank : 379)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	351	Target Neighborhood Hits	205	Shared Neighborhood Hits	15
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

ZFY21_HUMAN
NC score	0.061643 (rank : 380)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	351	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

RUFY2_MOUSE
NC score	0.061458 (rank : 381)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	351	Target Neighborhood Hits	820	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.061360 (rank : 382)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	351	Target Neighborhood Hits	765	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RBNS5_HUMAN
NC score	0.061274 (rank : 383)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	351	Target Neighborhood Hits	242	Shared Neighborhood Hits	40
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

GOGB1_HUMAN
NC score	0.061199 (rank : 384)	θ value	0.0113563 (rank : 143)
Query Neighborhood Hits	351	Target Neighborhood Hits	2297	Shared Neighborhood Hits	127
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SPTA1_MOUSE
NC score	0.061039 (rank : 385)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	351	Target Neighborhood Hits	675	Shared Neighborhood Hits	76
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

EFS_MOUSE
NC score	0.060586 (rank : 386)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	351	Target Neighborhood Hits	389	Shared Neighborhood Hits	38
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FYCO1_MOUSE
NC score	0.060251 (rank : 387)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	351	Target Neighborhood Hits	1059	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ANM2_MOUSE
NC score	0.060005 (rank : 388)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	351	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SI1L2_HUMAN
NC score	0.059812 (rank : 389)	θ value	0.47712 (rank : 207)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

RIMB2_MOUSE
NC score	0.059602 (rank : 390)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	351	Target Neighborhood Hits	246	Shared Neighborhood Hits	27
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PEPL_MOUSE
NC score	0.059197 (rank : 391)	θ value	0.813845 (rank : 214)
Query Neighborhood Hits	351	Target Neighborhood Hits	1105	Shared Neighborhood Hits	93
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PCNT_HUMAN
NC score	0.059018 (rank : 392)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	351	Target Neighborhood Hits	1551	Shared Neighborhood Hits	102
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

FYCO1_HUMAN
NC score	0.058749 (rank : 393)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	351	Target Neighborhood Hits	1149	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

EFS_HUMAN
NC score	0.058616 (rank : 394)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	351	Target Neighborhood Hits	348	Shared Neighborhood Hits	38
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

PDZD6_HUMAN
NC score	0.058537 (rank : 395)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	351	Target Neighborhood Hits	81	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

SI1L2_MOUSE
NC score	0.058346 (rank : 396)	θ value	0.47712 (rank : 208)
Query Neighborhood Hits	351	Target Neighborhood Hits	124	Shared Neighborhood Hits	56
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

PEX13_MOUSE
NC score	0.058276 (rank : 397)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	351	Target Neighborhood Hits	126	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RBNS5_MOUSE
NC score	0.058103 (rank : 398)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	351	Target Neighborhood Hits	266	Shared Neighborhood Hits	41
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

IFT81_MOUSE
NC score	0.057762 (rank : 399)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	351	Target Neighborhood Hits	959	Shared Neighborhood Hits	85
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

SPTA1_HUMAN
NC score	0.057668 (rank : 400)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	351	Target Neighborhood Hits	748	Shared Neighborhood Hits	83
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CT032_HUMAN
NC score	0.057668 (rank : 401)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	351	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

RIMB2_HUMAN
NC score	0.057593 (rank : 402)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	351	Target Neighborhood Hits	263	Shared Neighborhood Hits	26
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CASL_HUMAN
NC score	0.057382 (rank : 403)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	351	Target Neighborhood Hits	259	Shared Neighborhood Hits	30
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PEX13_HUMAN
NC score	0.057304 (rank : 404)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	351	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CROCC_MOUSE
NC score	0.057226 (rank : 405)	θ value	0.21417 (rank : 189)
Query Neighborhood Hits	351	Target Neighborhood Hits	1460	Shared Neighborhood Hits	106
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

ASPP1_MOUSE
NC score	0.056911 (rank : 406)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	351	Target Neighborhood Hits	1244	Shared Neighborhood Hits	102
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RHG04_HUMAN
NC score	0.056695 (rank : 407)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	351	Target Neighborhood Hits	307	Shared Neighborhood Hits	37
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RAD50_HUMAN
NC score	0.056678 (rank : 408)	θ value	2.36792 (rank : 250)
Query Neighborhood Hits	351	Target Neighborhood Hits	1317	Shared Neighborhood Hits	95
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

CE152_HUMAN
NC score	0.056165 (rank : 409)	θ value	5.27518 (rank : 289)
Query Neighborhood Hits	351	Target Neighborhood Hits	976	Shared Neighborhood Hits	83
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

GOGA4_HUMAN
NC score	0.055926 (rank : 410)	θ value	1.81305 (rank : 239)
Query Neighborhood Hits	351	Target Neighborhood Hits	2034	Shared Neighborhood Hits	121
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

T2_MOUSE
NC score	0.055636 (rank : 411)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	351	Target Neighborhood Hits	140	Shared Neighborhood Hits	24
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

SWP70_HUMAN
NC score	0.055382 (rank : 412)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	351	Target Neighborhood Hits	973	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CCD46_MOUSE
NC score	0.055363 (rank : 413)	θ value	1.81305 (rank : 236)
Query Neighborhood Hits	351	Target Neighborhood Hits	1405	Shared Neighborhood Hits	110
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

AKAP9_HUMAN
NC score	0.055337 (rank : 414)	θ value	1.06291 (rank : 218)
Query Neighborhood Hits	351	Target Neighborhood Hits	1710	Shared Neighborhood Hits	106
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ENAH_HUMAN
NC score	0.055135 (rank : 415)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	351	Target Neighborhood Hits	784	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

TCGAP_HUMAN
NC score	0.054985 (rank : 416)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	351	Target Neighborhood Hits	872	Shared Neighborhood Hits	56
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CCD96_HUMAN
NC score	0.054922 (rank : 417)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	351	Target Neighborhood Hits	595	Shared Neighborhood Hits	68
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

MAST1_HUMAN
NC score	0.054855 (rank : 418)	θ value	0.00102713 (rank : 103)
Query Neighborhood Hits	351	Target Neighborhood Hits	1146	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

CK5P2_HUMAN
NC score	0.054812 (rank : 419)	θ value	4.03905 (rank : 273)
Query Neighborhood Hits	351	Target Neighborhood Hits	1433	Shared Neighborhood Hits	107
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

HOOK3_MOUSE
NC score	0.054745 (rank : 420)	θ value	1.81305 (rank : 240)
Query Neighborhood Hits	351	Target Neighborhood Hits	1007	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

MAST1_MOUSE
NC score	0.054648 (rank : 421)	θ value	0.000786445 (rank : 100)
Query Neighborhood Hits	351	Target Neighborhood Hits	1123	Shared Neighborhood Hits	116
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

P85B_HUMAN
NC score	0.054368 (rank : 422)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	351	Target Neighborhood Hits	543	Shared Neighborhood Hits	62
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GOGA3_HUMAN
NC score	0.054305 (rank : 423)	θ value	3.0926 (rank : 262)
Query Neighborhood Hits	351	Target Neighborhood Hits	1317	Shared Neighborhood Hits	108
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

RAD50_MOUSE
NC score	0.054283 (rank : 424)	θ value	8.99809 (rank : 345)
Query Neighborhood Hits	351	Target Neighborhood Hits	1366	Shared Neighborhood Hits	97
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

MAST4_HUMAN
NC score	0.054167 (rank : 425)	θ value	0.00298849 (rank : 124)
Query Neighborhood Hits	351	Target Neighborhood Hits	1804	Shared Neighborhood Hits	141
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

XE7_HUMAN
NC score	0.054150 (rank : 426)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	351	Target Neighborhood Hits	738	Shared Neighborhood Hits	76
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

NUMA1_HUMAN
NC score	0.054093 (rank : 427)	θ value	5.27518 (rank : 306)
Query Neighborhood Hits	351	Target Neighborhood Hits	1523	Shared Neighborhood Hits	115
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

NBR1_HUMAN
NC score	0.054050 (rank : 428)	θ value	0.0330416 (rank : 158)
Query Neighborhood Hits	351	Target Neighborhood Hits	105	Shared Neighborhood Hits	12
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

SWP70_MOUSE
NC score	0.054008 (rank : 429)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	351	Target Neighborhood Hits	1097	Shared Neighborhood Hits	105
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MAST2_HUMAN
NC score	0.053859 (rank : 430)	θ value	0.00228821 (rank : 119)
Query Neighborhood Hits	351	Target Neighborhood Hits	1189	Shared Neighborhood Hits	121
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

RFIP3_HUMAN
NC score	0.053715 (rank : 431)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	351	Target Neighborhood Hits	1055	Shared Neighborhood Hits	90
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

CCD13_HUMAN
NC score	0.053709 (rank : 432)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	351	Target Neighborhood Hits	721	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

HOOK3_HUMAN
NC score	0.053503 (rank : 433)	θ value	2.36792 (rank : 245)
Query Neighborhood Hits	351	Target Neighborhood Hits	1070	Shared Neighborhood Hits	89
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

NEBU_HUMAN
NC score	0.053470 (rank : 434)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	351	Target Neighborhood Hits	420	Shared Neighborhood Hits	41
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

INVO_HUMAN
NC score	0.053407 (rank : 435)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	351	Target Neighborhood Hits	636	Shared Neighborhood Hits	65
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

AZI1_HUMAN
NC score	0.053284 (rank : 436)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	351	Target Neighborhood Hits	1000	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CAR10_HUMAN
NC score	0.052963 (rank : 437)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	351	Target Neighborhood Hits	569	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

ZC313_HUMAN
NC score	0.052936 (rank : 438)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	351	Target Neighborhood Hits	772	Shared Neighborhood Hits	71
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

PEPL_HUMAN
NC score	0.052890 (rank : 439)	θ value	8.99809 (rank : 344)
Query Neighborhood Hits	351	Target Neighborhood Hits	1141	Shared Neighborhood Hits	91
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

CCD96_MOUSE
NC score	0.052862 (rank : 440)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	351	Target Neighborhood Hits	704	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CENPF_HUMAN
NC score	0.052604 (rank : 441)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	351	Target Neighborhood Hits	1932	Shared Neighborhood Hits	119
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

PIBF1_HUMAN
NC score	0.052519 (rank : 442)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	351	Target Neighborhood Hits	1041	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

MOES_HUMAN
NC score	0.052454 (rank : 443)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	351	Target Neighborhood Hits	892	Shared Neighborhood Hits	87
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

TAXB1_HUMAN
NC score	0.052440 (rank : 444)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	351	Target Neighborhood Hits	829	Shared Neighborhood Hits	72
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

LRC45_MOUSE
NC score	0.052416 (rank : 445)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	351	Target Neighborhood Hits	959	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MAST2_MOUSE
NC score	0.052403 (rank : 446)	θ value	0.00869519 (rank : 140)
Query Neighborhood Hits	351	Target Neighborhood Hits	1110	Shared Neighborhood Hits	120
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MOES_MOUSE
NC score	0.052392 (rank : 447)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	351	Target Neighborhood Hits	923	Shared Neighborhood Hits	89
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

CEP63_HUMAN
NC score	0.052317 (rank : 448)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	351	Target Neighborhood Hits	1005	Shared Neighborhood Hits	90
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

IF3A_MOUSE
NC score	0.052155 (rank : 449)	θ value	8.99809 (rank : 340)
Query Neighborhood Hits	351	Target Neighborhood Hits	871	Shared Neighborhood Hits	85
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

CASL_MOUSE
NC score	0.051863 (rank : 450)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	351	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

FLIP1_HUMAN
NC score	0.051855 (rank : 451)	θ value	8.99809 (rank : 337)
Query Neighborhood Hits	351	Target Neighborhood Hits	1405	Shared Neighborhood Hits	100
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

DESP_HUMAN
NC score	0.051752 (rank : 452)	θ value	5.27518 (rank : 294)
Query Neighborhood Hits	351	Target Neighborhood Hits	1470	Shared Neighborhood Hits	100
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

IFT74_HUMAN
NC score	0.051686 (rank : 453)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	351	Target Neighborhood Hits	949	Shared Neighborhood Hits	75
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

MD1L1_MOUSE
NC score	0.051665 (rank : 454)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	351	Target Neighborhood Hits	1001	Shared Neighborhood Hits	81
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

CCD46_HUMAN
NC score	0.051449 (rank : 455)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	351	Target Neighborhood Hits	1430	Shared Neighborhood Hits	105
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

HMMR_MOUSE
NC score	0.051393 (rank : 456)	θ value	8.99809 (rank : 338)
Query Neighborhood Hits	351	Target Neighborhood Hits	1178	Shared Neighborhood Hits	94
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

MAST3_HUMAN
NC score	0.051335 (rank : 457)	θ value	0.0148317 (rank : 145)
Query Neighborhood Hits	351	Target Neighborhood Hits	1128	Shared Neighborhood Hits	116
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

GOGA4_MOUSE
NC score	0.051296 (rank : 458)	θ value	3.0926 (rank : 263)
Query Neighborhood Hits	351	Target Neighborhood Hits	1939	Shared Neighborhood Hits	112
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ASPP1_HUMAN
NC score	0.051238 (rank : 459)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	351	Target Neighborhood Hits	956	Shared Neighborhood Hits	86
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CP135_MOUSE
NC score	0.051160 (rank : 460)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	351	Target Neighborhood Hits	1278	Shared Neighborhood Hits	95
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

P85B_MOUSE
NC score	0.051157 (rank : 461)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	351	Target Neighborhood Hits	519	Shared Neighborhood Hits	59
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CNTRB_MOUSE
NC score	0.051102 (rank : 462)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	351	Target Neighborhood Hits	1029	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

OBSCN_HUMAN
NC score	0.051015 (rank : 463)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	351	Target Neighborhood Hits	1931	Shared Neighborhood Hits	85
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

IF3A_HUMAN
NC score	0.050985 (rank : 464)	θ value	8.99809 (rank : 339)
Query Neighborhood Hits	351	Target Neighborhood Hits	875	Shared Neighborhood Hits	85
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

RB6I2_MOUSE
NC score	0.050962 (rank : 465)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	351	Target Neighborhood Hits	1433	Shared Neighborhood Hits	103
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

CI093_HUMAN
NC score	0.050619 (rank : 466)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	351	Target Neighborhood Hits	1088	Shared Neighborhood Hits	92
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

SDCG8_HUMAN
NC score	0.050486 (rank : 467)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	351	Target Neighborhood Hits	1002	Shared Neighborhood Hits	88
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

RB6I2_HUMAN
NC score	0.050247 (rank : 468)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	351	Target Neighborhood Hits	1584	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

INCE_MOUSE
NC score	0.050246 (rank : 469)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	351	Target Neighborhood Hits	903	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

TRIPB_HUMAN
NC score	0.050166 (rank : 470)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	351	Target Neighborhood Hits	1587	Shared Neighborhood Hits	114
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

PCQAP_HUMAN
NC score	0.050079 (rank : 471)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	351	Target Neighborhood Hits	549	Shared Neighborhood Hits	51
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

TPM3_HUMAN
NC score	0.049853 (rank : 472)	θ value	0.365318 (rank : 202)
Query Neighborhood Hits	351	Target Neighborhood Hits	689	Shared Neighborhood Hits	67
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

CF060_HUMAN
NC score	0.049634 (rank : 473)	θ value	1.38821 (rank : 228)
Query Neighborhood Hits	351	Target Neighborhood Hits	1270	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

TPM3_MOUSE
NC score	0.049481 (rank : 474)	θ value	0.365318 (rank : 203)
Query Neighborhood Hits	351	Target Neighborhood Hits	676	Shared Neighborhood Hits	67
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

TARA_MOUSE
NC score	0.048977 (rank : 475)	θ value	2.36792 (rank : 255)
Query Neighborhood Hits	351	Target Neighborhood Hits	1133	Shared Neighborhood Hits	88
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RRBP1_MOUSE
NC score	0.048897 (rank : 476)	θ value	0.0431538 (rank : 164)
Query Neighborhood Hits	351	Target Neighborhood Hits	1650	Shared Neighborhood Hits	100
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

EZRI_HUMAN
NC score	0.048896 (rank : 477)	θ value	4.03905 (rank : 276)
Query Neighborhood Hits	351	Target Neighborhood Hits	663	Shared Neighborhood Hits	78
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

IFT74_MOUSE
NC score	0.048649 (rank : 478)	θ value	6.88961 (rank : 319)
Query Neighborhood Hits	351	Target Neighborhood Hits	939	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

TPM1_MOUSE
NC score	0.048611 (rank : 479)	θ value	1.06291 (rank : 226)
Query Neighborhood Hits	351	Target Neighborhood Hits	729	Shared Neighborhood Hits	74
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_HUMAN
NC score	0.048548 (rank : 480)	θ value	1.06291 (rank : 225)
Query Neighborhood Hits	351	Target Neighborhood Hits	716	Shared Neighborhood Hits	72
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TARA_HUMAN
NC score	0.048440 (rank : 481)	θ value	4.03905 (rank : 285)
Query Neighborhood Hits	351	Target Neighborhood Hits	1626	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SMC2_HUMAN
NC score	0.047875 (rank : 482)	θ value	8.99809 (rank : 348)
Query Neighborhood Hits	351	Target Neighborhood Hits	1405	Shared Neighborhood Hits	95
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

RL21_MOUSE
NC score	0.047859 (rank : 483)	θ value	0.813845 (rank : 215)
Query Neighborhood Hits	351	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	O09167	Gene names	Rpl21
Domain Architecture
Description	60S ribosomal protein L21.

SRRM2_MOUSE
NC score	0.047349 (rank : 484)	θ value	8.99809 (rank : 349)
Query Neighborhood Hits	351	Target Neighborhood Hits	1470	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CF152_HUMAN
NC score	0.046913 (rank : 485)	θ value	5.27518 (rank : 290)
Query Neighborhood Hits	351	Target Neighborhood Hits	704	Shared Neighborhood Hits	81
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CING_MOUSE
NC score	0.046757 (rank : 486)	θ value	8.99809 (rank : 333)
Query Neighborhood Hits	351	Target Neighborhood Hits	1432	Shared Neighborhood Hits	99
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

SYNE2_HUMAN
NC score	0.046633 (rank : 487)	θ value	3.0926 (rank : 265)
Query Neighborhood Hits	351	Target Neighborhood Hits	1323	Shared Neighborhood Hits	104
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MAP9_MOUSE
NC score	0.046339 (rank : 488)	θ value	5.27518 (rank : 303)
Query Neighborhood Hits	351	Target Neighborhood Hits	529	Shared Neighborhood Hits	59
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

CALD1_HUMAN
NC score	0.045423 (rank : 489)	θ value	8.99809 (rank : 332)
Query Neighborhood Hits	351	Target Neighborhood Hits	959	Shared Neighborhood Hits	87
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

K1543_MOUSE
NC score	0.045231 (rank : 490)	θ value	0.0961366 (rank : 174)
Query Neighborhood Hits	351	Target Neighborhood Hits	497	Shared Neighborhood Hits	44
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

RBP24_HUMAN
NC score	0.044383 (rank : 491)	θ value	5.27518 (rank : 309)
Query Neighborhood Hits	351	Target Neighborhood Hits	1559	Shared Neighborhood Hits	100
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.044300 (rank : 492)	θ value	5.27518 (rank : 297)
Query Neighborhood Hits	351	Target Neighborhood Hits	1558	Shared Neighborhood Hits	100
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

HTRA4_HUMAN
NC score	0.043343 (rank : 493)	θ value	5.27518 (rank : 300)
Query Neighborhood Hits	351	Target Neighborhood Hits	119	Shared Neighborhood Hits	38
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

CENPE_HUMAN
NC score	0.043221 (rank : 494)	θ value	6.88961 (rank : 317)
Query Neighborhood Hits	351	Target Neighborhood Hits	2060	Shared Neighborhood Hits	119
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

PLEC1_HUMAN
NC score	0.042579 (rank : 495)	θ value	5.27518 (rank : 307)
Query Neighborhood Hits	351	Target Neighborhood Hits	1326	Shared Neighborhood Hits	99
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

RL21_HUMAN
NC score	0.042459 (rank : 496)	θ value	1.38821 (rank : 233)
Query Neighborhood Hits	351	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P46778, Q16699	Gene names	RPL21
Domain Architecture
Description	60S ribosomal protein L21.

BSN_HUMAN
NC score	0.042434 (rank : 497)	θ value	8.99809 (rank : 330)
Query Neighborhood Hits	351	Target Neighborhood Hits	1537	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

SMC2_MOUSE
NC score	0.041739 (rank : 498)	θ value	3.0926 (rank : 264)
Query Neighborhood Hits	351	Target Neighborhood Hits	1131	Shared Neighborhood Hits	90
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

MYH11_HUMAN
NC score	0.040057 (rank : 499)	θ value	0.365318 (rank : 200)
Query Neighborhood Hits	351	Target Neighborhood Hits	1806	Shared Neighborhood Hits	115
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
NC score	0.039845 (rank : 500)	θ value	0.47712 (rank : 206)
Query Neighborhood Hits	351	Target Neighborhood Hits	1777	Shared Neighborhood Hits	112
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NCOAT_HUMAN
NC score	0.039398 (rank : 501)	θ value	0.62314 (rank : 211)
Query Neighborhood Hits	351	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0	Gene names	MGEA5, HEXC, KIAA0679, MEA5
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

NBR1_MOUSE
NC score	0.039259 (rank : 502)	θ value	2.36792 (rank : 249)
Query Neighborhood Hits	351	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

MYH9_HUMAN
NC score	0.039174 (rank : 503)	θ value	4.03905 (rank : 279)
Query Neighborhood Hits	351	Target Neighborhood Hits	1762	Shared Neighborhood Hits	113
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

TACC2_MOUSE
NC score	0.038235 (rank : 504)	θ value	8.99809 (rank : 350)
Query Neighborhood Hits	351	Target Neighborhood Hits	774	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TNNT2_MOUSE
NC score	0.037515 (rank : 505)	θ value	4.03905 (rank : 286)
Query Neighborhood Hits	351	Target Neighborhood Hits	395	Shared Neighborhood Hits	51
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

CTGE5_MOUSE
NC score	0.036719 (rank : 506)	θ value	4.03905 (rank : 275)
Query Neighborhood Hits	351	Target Neighborhood Hits	928	Shared Neighborhood Hits	84
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

UACA_MOUSE
NC score	0.036438 (rank : 507)	θ value	6.88961 (rank : 329)
Query Neighborhood Hits	351	Target Neighborhood Hits	1620	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

MYH10_HUMAN
NC score	0.034910 (rank : 508)	θ value	4.03905 (rank : 278)
Query Neighborhood Hits	351	Target Neighborhood Hits	1620	Shared Neighborhood Hits	107
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CTRO_MOUSE
NC score	0.034896 (rank : 509)	θ value	5.27518 (rank : 293)
Query Neighborhood Hits	351	Target Neighborhood Hits	2344	Shared Neighborhood Hits	116
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

BRD4_MOUSE
NC score	0.034532 (rank : 510)	θ value	1.38821 (rank : 227)
Query Neighborhood Hits	351	Target Neighborhood Hits	845	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CENPQ_HUMAN
NC score	0.034526 (rank : 511)	θ value	4.03905 (rank : 272)
Query Neighborhood Hits	351	Target Neighborhood Hits	131	Shared Neighborhood Hits	28
SwissProt Accessions	Q7L2Z9, Q6IN61, Q9NVS5	Gene names	CENPQ, C6orf139
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

SDPR_MOUSE
NC score	0.033372 (rank : 512)	θ value	6.88961 (rank : 327)
Query Neighborhood Hits	351	Target Neighborhood Hits	485	Shared Neighborhood Hits	55
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

MYO10_HUMAN
NC score	0.032485 (rank : 513)	θ value	1.38821 (rank : 231)
Query Neighborhood Hits	351	Target Neighborhood Hits	920	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CTRO_HUMAN
NC score	0.031102 (rank : 514)	θ value	6.88961 (rank : 318)
Query Neighborhood Hits	351	Target Neighborhood Hits	2092	Shared Neighborhood Hits	113
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

FMNL_MOUSE
NC score	0.031097 (rank : 515)	θ value	0.279714 (rank : 197)
Query Neighborhood Hits	351	Target Neighborhood Hits	428	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

MDC1_MOUSE
NC score	0.030552 (rank : 516)	θ value	1.06291 (rank : 223)
Query Neighborhood Hits	351	Target Neighborhood Hits	998	Shared Neighborhood Hits	56
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

BRD4_HUMAN
NC score	0.030385 (rank : 517)	θ value	4.03905 (rank : 271)
Query Neighborhood Hits	351	Target Neighborhood Hits	851	Shared Neighborhood Hits	64
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

GRIPE_HUMAN
NC score	0.030371 (rank : 518)	θ value	1.06291 (rank : 220)
Query Neighborhood Hits	351	Target Neighborhood Hits	69	Shared Neighborhood Hits	8
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

TAD3L_HUMAN
NC score	0.028651 (rank : 519)	θ value	2.36792 (rank : 253)
Query Neighborhood Hits	351	Target Neighborhood Hits	189	Shared Neighborhood Hits	30
SwissProt Accessions	O75528, Q9UFS2	Gene names	TADA3L, ADA3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (hADA3).

TAD3L_MOUSE
NC score	0.028332 (rank : 520)	θ value	2.36792 (rank : 254)
Query Neighborhood Hits	351	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R0L9, Q8CIH4, Q8K289, Q8R5E3, Q9CTJ0	Gene names	Tada3l, Ada3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (mADA3).

MPP10_MOUSE
NC score	0.027723 (rank : 521)	θ value	0.47712 (rank : 205)
Query Neighborhood Hits	351	Target Neighborhood Hits	251	Shared Neighborhood Hits	27
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

PELP1_HUMAN
NC score	0.026607 (rank : 522)	θ value	6.88961 (rank : 323)
Query Neighborhood Hits	351	Target Neighborhood Hits	596	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

GTSE1_MOUSE
NC score	0.026471 (rank : 523)	θ value	1.38821 (rank : 229)
Query Neighborhood Hits	351	Target Neighborhood Hits	245	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

DIAP1_HUMAN
NC score	0.025156 (rank : 524)	θ value	3.0926 (rank : 257)
Query Neighborhood Hits	351	Target Neighborhood Hits	784	Shared Neighborhood Hits	71
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

IKBL_HUMAN
NC score	0.024876 (rank : 525)	θ value	1.38821 (rank : 230)
Query Neighborhood Hits	351	Target Neighborhood Hits	168	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

SENP3_HUMAN
NC score	0.023544 (rank : 526)	θ value	2.36792 (rank : 252)
Query Neighborhood Hits	351	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4L4, Q96PS4, Q9Y3W9	Gene names	SENP3, SSP3, SUSP3
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3).

CLCA_MOUSE
NC score	0.023508 (rank : 527)	θ value	4.03905 (rank : 274)
Query Neighborhood Hits	351	Target Neighborhood Hits	106	Shared Neighborhood Hits	21
SwissProt Accessions	O08585	Gene names	Clta
Domain Architecture
Description	Clathrin light chain A (Lca).

GBP2_HUMAN
NC score	0.023047 (rank : 528)	θ value	4.03905 (rank : 277)
Query Neighborhood Hits	351	Target Neighborhood Hits	349	Shared Neighborhood Hits	48
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

RAE1_HUMAN
NC score	0.021501 (rank : 529)	θ value	4.03905 (rank : 283)
Query Neighborhood Hits	351	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	P24386, O43732	Gene names	CHM, REP1, TCD
Domain Architecture
Description	Rab proteins geranylgeranyltransferase component A 1 (Rab escort protein 1) (REP-1) (Choroideraemia protein) (TCD protein).

LAP2B_HUMAN
NC score	0.021481 (rank : 530)	θ value	1.06291 (rank : 221)
Query Neighborhood Hits	351	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	P42167, Q14861	Gene names	TMPO, LAP2
Domain Architecture
Description	Lamina-associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin-related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Contains: Thymopoietin (TP) (Splenin); Thymopentin (TP5)].

NASP_HUMAN
NC score	0.020667 (rank : 531)	θ value	4.03905 (rank : 280)
Query Neighborhood Hits	351	Target Neighborhood Hits	709	Shared Neighborhood Hits	55
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

CUTL2_MOUSE
NC score	0.020599 (rank : 532)	θ value	8.99809 (rank : 335)
Query Neighborhood Hits	351	Target Neighborhood Hits	771	Shared Neighborhood Hits	67
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

TOX_HUMAN
NC score	0.020511 (rank : 533)	θ value	0.813845 (rank : 216)
Query Neighborhood Hits	351	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	O94900, Q96AV5	Gene names	TOX, KIAA0808
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

AR13B_HUMAN
NC score	0.020348 (rank : 534)	θ value	2.36792 (rank : 241)
Query Neighborhood Hits	351	Target Neighborhood Hits	528	Shared Neighborhood Hits	48
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

NCOAT_MOUSE
NC score	0.020267 (rank : 535)	θ value	5.27518 (rank : 305)
Query Neighborhood Hits	351	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQQ9, Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7	Gene names	Mgea5, Hexc, Kiaa0679
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

APC_MOUSE
NC score	0.017102 (rank : 536)	θ value	6.88961 (rank : 314)
Query Neighborhood Hits	351	Target Neighborhood Hits	441	Shared Neighborhood Hits	50
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

CBP_HUMAN
NC score	0.016971 (rank : 537)	θ value	6.88961 (rank : 315)
Query Neighborhood Hits	351	Target Neighborhood Hits	941	Shared Neighborhood Hits	40
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

TOX_MOUSE
NC score	0.016834 (rank : 538)	θ value	2.36792 (rank : 256)
Query Neighborhood Hits	351	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

CBL_MOUSE
NC score	0.016613 (rank : 539)	θ value	1.81305 (rank : 235)
Query Neighborhood Hits	351	Target Neighborhood Hits	426	Shared Neighborhood Hits	26
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

S6OS1_HUMAN
NC score	0.016611 (rank : 540)	θ value	5.27518 (rank : 310)
Query Neighborhood Hits	351	Target Neighborhood Hits	134	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N1H7	Gene names	SIX6OS1, C14orf39
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

MUCDL_HUMAN
NC score	0.016553 (rank : 541)	θ value	5.27518 (rank : 304)
Query Neighborhood Hits	351	Target Neighborhood Hits	777	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SENP3_MOUSE
NC score	0.016431 (rank : 542)	θ value	8.99809 (rank : 347)
Query Neighborhood Hits	351	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).

MAD3_HUMAN
NC score	0.016162 (rank : 543)	θ value	6.88961 (rank : 320)
Query Neighborhood Hits	351	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

ACD_MOUSE
NC score	0.015469 (rank : 544)	θ value	4.03905 (rank : 268)
Query Neighborhood Hits	351	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q5EE38, Q3TBB1, Q3TUR7, Q3UKL6, Q3V3Y1, Q99KF8	Gene names	Acd
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein.

BUB1B_HUMAN
NC score	0.015425 (rank : 545)	θ value	8.99809 (rank : 331)
Query Neighborhood Hits	351	Target Neighborhood Hits	208	Shared Neighborhood Hits	26
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

SVIL_MOUSE
NC score	0.015066 (rank : 546)	θ value	4.03905 (rank : 284)
Query Neighborhood Hits	351	Target Neighborhood Hits	439	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

ELF1_MOUSE
NC score	0.014525 (rank : 547)	θ value	5.27518 (rank : 296)
Query Neighborhood Hits	351	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

KIF17_MOUSE
NC score	0.014111 (rank : 548)	θ value	8.99809 (rank : 341)
Query Neighborhood Hits	351	Target Neighborhood Hits	452	Shared Neighborhood Hits	55
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

K1C14_MOUSE
NC score	0.013505 (rank : 549)	θ value	2.36792 (rank : 246)
Query Neighborhood Hits	351	Target Neighborhood Hits	501	Shared Neighborhood Hits	60
SwissProt Accessions	Q61781, Q91VQ4	Gene names	Krt14, Krt1-14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

RANB3_MOUSE
NC score	0.013190 (rank : 550)	θ value	5.27518 (rank : 308)
Query Neighborhood Hits	351	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CT10, Q3TIS4, Q3U2G4, Q3UYG7	Gene names	Ranbp3
Domain Architecture	No domain graphic available
Description	Ran-binding protein 3 (RanBP3).

PAR14_MOUSE
NC score	0.011812 (rank : 551)	θ value	1.38821 (rank : 232)
Query Neighborhood Hits	351	Target Neighborhood Hits	113	Shared Neighborhood Hits	11
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

TULP3_MOUSE
NC score	0.011364 (rank : 552)	θ value	1.38821 (rank : 234)
Query Neighborhood Hits	351	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	O88413	Gene names	Tulp3
Domain Architecture
Description	Tubby-related protein 3 (Tubby-like protein 3).

GP156_HUMAN
NC score	0.011300 (rank : 553)	θ value	5.27518 (rank : 299)
Query Neighborhood Hits	351	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

TRI32_MOUSE
NC score	0.010600 (rank : 554)	θ value	3.0926 (rank : 267)
Query Neighborhood Hits	351	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

CP238_MOUSE
NC score	0.010393 (rank : 555)	θ value	0.279714 (rank : 196)
Query Neighborhood Hits	351	Target Neighborhood Hits	112	Shared Neighborhood Hits	6
SwissProt Accessions	P56655	Gene names	Cyp2c38
Domain Architecture
Description	Cytochrome P450 2C38 (EC 1.14.14.1) (CYPIIC38).

TRIM6_MOUSE
NC score	0.010360 (rank : 556)	θ value	4.03905 (rank : 287)
Query Neighborhood Hits	351	Target Neighborhood Hits	451	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

LRFN4_MOUSE
NC score	0.010240 (rank : 557)	θ value	5.27518 (rank : 302)
Query Neighborhood Hits	351	Target Neighborhood Hits	442	Shared Neighborhood Hits	11
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

ANR47_HUMAN
NC score	0.010150 (rank : 558)	θ value	4.03905 (rank : 269)
Query Neighborhood Hits	351	Target Neighborhood Hits	369	Shared Neighborhood Hits	15
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

TRI32_HUMAN
NC score	0.009394 (rank : 559)	θ value	5.27518 (rank : 313)
Query Neighborhood Hits	351	Target Neighborhood Hits	264	Shared Neighborhood Hits	23
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

APBB1_MOUSE
NC score	0.009192 (rank : 560)	θ value	4.03905 (rank : 270)
Query Neighborhood Hits	351	Target Neighborhood Hits	75	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

SEN54_MOUSE
NC score	0.009181 (rank : 561)	θ value	6.88961 (rank : 328)
Query Neighborhood Hits	351	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C2A2, Q9DCI5	Gene names	Tsen54, Sen54
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen54 (tRNA-intron endonuclease Sen54).

CP007_HUMAN
NC score	0.008881 (rank : 562)	θ value	8.99809 (rank : 334)
Query Neighborhood Hits	351	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2B5	Gene names	C16orf7, ATPBL
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 (Protein ATP-BL).

OSBP1_HUMAN
NC score	0.008107 (rank : 563)	θ value	4.03905 (rank : 282)
Query Neighborhood Hits	351	Target Neighborhood Hits	180	Shared Neighborhood Hits	20
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

TM1L1_HUMAN
NC score	0.007553 (rank : 564)	θ value	5.27518 (rank : 312)
Query Neighborhood Hits	351	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	O75674	Gene names	TOM1L1, SRCASM
Domain Architecture
Description	TOM1-like 1 protein (Target of myb-like 1 protein) (Src-activating and signaling molecule protein).

EXOC2_MOUSE
NC score	0.006797 (rank : 565)	θ value	8.99809 (rank : 336)
Query Neighborhood Hits	351	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D4H1	Gene names	Exoc2, Sec5, Sec5l1
Domain Architecture
Description	Exocyst complex component 2 (Exocyst complex component Sec5).

RFTN1_HUMAN
NC score	0.006431 (rank : 566)	θ value	8.99809 (rank : 346)
Query Neighborhood Hits	351	Target Neighborhood Hits	72	Shared Neighborhood Hits	6
SwissProt Accessions	Q14699, Q496Y2, Q4QQI7, Q5JB48, Q7Z7P2	Gene names	RFTN1, KIAA0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein) (Cell migration-inducing gene 2 protein).

CCNT2_HUMAN
NC score	0.006245 (rank : 567)	θ value	6.88961 (rank : 316)
Query Neighborhood Hits	351	Target Neighborhood Hits	84	Shared Neighborhood Hits	6
SwissProt Accessions	O60583, O60582, Q5I1Y0	Gene names	CCNT2
Domain Architecture
Description	Cyclin-T2 (CycT2).

CP239_MOUSE
NC score	0.005796 (rank : 568)	θ value	5.27518 (rank : 291)
Query Neighborhood Hits	351	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	P56656	Gene names	Cyp2c39
Domain Architecture
Description	Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39).

NEK11_HUMAN
NC score	0.005776 (rank : 569)	θ value	6.88961 (rank : 322)
Query Neighborhood Hits	351	Target Neighborhood Hits	1043	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NRIP1_MOUSE
NC score	0.005717 (rank : 570)	θ value	8.99809 (rank : 343)
Query Neighborhood Hits	351	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CBD1, Q8C3Y8, Q9Z2K2	Gene names	Nrip1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

OPHN1_MOUSE
NC score	0.005396 (rank : 571)	θ value	4.03905 (rank : 281)
Query Neighborhood Hits	351	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

CP2C8_HUMAN
NC score	0.005373 (rank : 572)	θ value	1.81305 (rank : 237)
Query Neighborhood Hits	351	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	P10632	Gene names	CYP2C8
Domain Architecture
Description	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase).

ACK1_HUMAN
NC score	0.004738 (rank : 573)	θ value	1.06291 (rank : 217)
Query Neighborhood Hits	351	Target Neighborhood Hits	1140	Shared Neighborhood Hits	34
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

CP2AC_MOUSE
NC score	0.004031 (rank : 574)	θ value	5.27518 (rank : 292)
Query Neighborhood Hits	351	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	P56593	Gene names	Cyp2a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7- alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase).

UTX_HUMAN
NC score	0.003893 (rank : 575)	θ value	8.99809 (rank : 351)
Query Neighborhood Hits	351	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

HNF3G_MOUSE
NC score	0.002053 (rank : 576)	θ value	2.36792 (rank : 244)
Query Neighborhood Hits	351	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	P35584	Gene names	Foxa3, Hnf3g, Tcf-3g, Tcf3g
Domain Architecture
Description	Hepatocyte nuclear factor 3-gamma (HNF-3G) (Forkhead box protein A3).

NEDD1_MOUSE
NC score	0.001605 (rank : 577)	θ value	6.88961 (rank : 321)
Query Neighborhood Hits	351	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

IRAK1_HUMAN
NC score	0.001491 (rank : 578)	θ value	5.27518 (rank : 301)
Query Neighborhood Hits	351	Target Neighborhood Hits	820	Shared Neighborhood Hits	19
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

ARX_MOUSE
NC score	0.000451 (rank : 579)	θ value	1.06291 (rank : 219)
Query Neighborhood Hits	351	Target Neighborhood Hits	398	Shared Neighborhood Hits	10
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

LPHN1_HUMAN
NC score	0.000151 (rank : 580)	θ value	8.99809 (rank : 342)
Query Neighborhood Hits	351	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	O94910, Q96IE7, Q9BU07, Q9HAR3	Gene names	LPHN1, KIAA0821, LEC2
Domain Architecture
Description	Latrophilin-1 precursor (Calcium-independent alpha-latrotoxin receptor 1) (Lectomedin-2).