Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : EFS_MOUSE

For an explanation of this page, click here

EFS_MOUSE
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EFS_HUMAN
θ value	0 (rank : 1)	NC score	0.907693 (rank : 2)
Query Neighborhood Hits	389	Target Neighborhood Hits	348	Shared Neighborhood Hits	213
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	389	Target Neighborhood Hits	389	Shared Neighborhood Hits	389
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_HUMAN
θ value	5.40856e-29 (rank : 3)	NC score	0.719967 (rank : 4)
Query Neighborhood Hits	389	Target Neighborhood Hits	554	Shared Neighborhood Hits	231
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	2.68423e-28 (rank : 4)	NC score	0.732342 (rank : 3)
Query Neighborhood Hits	389	Target Neighborhood Hits	438	Shared Neighborhood Hits	213
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
θ value	1.05554e-24 (rank : 5)	NC score	0.701900 (rank : 6)
Query Neighborhood Hits	389	Target Neighborhood Hits	259	Shared Neighborhood Hits	150
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	1.37858e-24 (rank : 6)	NC score	0.709061 (rank : 5)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	145
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CT032_HUMAN
θ value	1.29331e-14 (rank : 7)	NC score	0.668363 (rank : 7)
Query Neighborhood Hits	389	Target Neighborhood Hits	235	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PEX13_HUMAN
θ value	3.41135e-07 (rank : 8)	NC score	0.491014 (rank : 8)
Query Neighborhood Hits	389	Target Neighborhood Hits	128	Shared Neighborhood Hits	110
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	3.41135e-07 (rank : 9)	NC score	0.486404 (rank : 9)
Query Neighborhood Hits	389	Target Neighborhood Hits	126	Shared Neighborhood Hits	108
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

M3KL4_HUMAN
θ value	1.29631e-06 (rank : 10)	NC score	0.134567 (rank : 161)
Query Neighborhood Hits	389	Target Neighborhood Hits	1087	Shared Neighborhood Hits	159
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

IASPP_MOUSE
θ value	1.69304e-06 (rank : 11)	NC score	0.343998 (rank : 55)
Query Neighborhood Hits	389	Target Neighborhood Hits	1024	Shared Neighborhood Hits	234
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PCD15_HUMAN
θ value	2.21117e-06 (rank : 12)	NC score	0.034335 (rank : 552)
Query Neighborhood Hits	389	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

VINEX_MOUSE
θ value	2.21117e-06 (rank : 13)	NC score	0.465832 (rank : 11)
Query Neighborhood Hits	389	Target Neighborhood Hits	286	Shared Neighborhood Hits	165
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

IASPP_HUMAN
θ value	3.77169e-06 (rank : 14)	NC score	0.344989 (rank : 53)
Query Neighborhood Hits	389	Target Neighborhood Hits	688	Shared Neighborhood Hits	177
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PPIP1_HUMAN
θ value	4.92598e-06 (rank : 15)	NC score	0.458005 (rank : 12)
Query Neighborhood Hits	389	Target Neighborhood Hits	389	Shared Neighborhood Hits	164
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

VINEX_HUMAN
θ value	4.92598e-06 (rank : 16)	NC score	0.456197 (rank : 13)
Query Neighborhood Hits	389	Target Neighborhood Hits	270	Shared Neighborhood Hits	158
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

MUC1_HUMAN
θ value	4.1701e-05 (rank : 17)	NC score	0.134371 (rank : 162)
Query Neighborhood Hits	389	Target Neighborhood Hits	975	Shared Neighborhood Hits	142
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SF3A1_MOUSE
θ value	4.1701e-05 (rank : 18)	NC score	0.153753 (rank : 145)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

PPIP1_MOUSE
θ value	5.44631e-05 (rank : 19)	NC score	0.450517 (rank : 14)
Query Neighborhood Hits	389	Target Neighborhood Hits	377	Shared Neighborhood Hits	163
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RUSC1_HUMAN
θ value	5.44631e-05 (rank : 20)	NC score	0.371007 (rank : 40)
Query Neighborhood Hits	389	Target Neighborhood Hits	226	Shared Neighborhood Hits	127
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SF3A1_HUMAN
θ value	9.29e-05 (rank : 21)	NC score	0.145641 (rank : 151)
Query Neighborhood Hits	389	Target Neighborhood Hits	199	Shared Neighborhood Hits	31
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

RUSC2_HUMAN
θ value	0.000121331 (rank : 22)	NC score	0.239928 (rank : 104)
Query Neighborhood Hits	389	Target Neighborhood Hits	205	Shared Neighborhood Hits	75
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CD2AP_MOUSE
θ value	0.00020696 (rank : 23)	NC score	0.466437 (rank : 10)
Query Neighborhood Hits	389	Target Neighborhood Hits	336	Shared Neighborhood Hits	166
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GRB2_HUMAN
θ value	0.00020696 (rank : 24)	NC score	0.389088 (rank : 25)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	164
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00020696 (rank : 25)	NC score	0.388478 (rank : 26)
Query Neighborhood Hits	389	Target Neighborhood Hits	312	Shared Neighborhood Hits	164
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

RUSC1_MOUSE
θ value	0.000270298 (rank : 26)	NC score	0.340317 (rank : 57)
Query Neighborhood Hits	389	Target Neighborhood Hits	206	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3K1_MOUSE
θ value	0.000270298 (rank : 27)	NC score	0.444925 (rank : 16)
Query Neighborhood Hits	389	Target Neighborhood Hits	332	Shared Neighborhood Hits	155
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

AHI1_MOUSE
θ value	0.000602161 (rank : 28)	NC score	0.294978 (rank : 74)
Query Neighborhood Hits	389	Target Neighborhood Hits	496	Shared Neighborhood Hits	156
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CS016_HUMAN
θ value	0.000602161 (rank : 29)	NC score	0.146595 (rank : 150)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

ITSN1_MOUSE
θ value	0.000602161 (rank : 30)	NC score	0.280540 (rank : 85)
Query Neighborhood Hits	389	Target Neighborhood Hits	1669	Shared Neighborhood Hits	212
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NCK2_HUMAN
θ value	0.000602161 (rank : 31)	NC score	0.375041 (rank : 36)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	165
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3K1_HUMAN
θ value	0.000602161 (rank : 32)	NC score	0.444755 (rank : 17)
Query Neighborhood Hits	389	Target Neighborhood Hits	341	Shared Neighborhood Hits	153
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SNX18_MOUSE
θ value	0.000602161 (rank : 33)	NC score	0.321682 (rank : 63)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	121
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

AHI1_HUMAN
θ value	0.00102713 (rank : 34)	NC score	0.300231 (rank : 73)
Query Neighborhood Hits	389	Target Neighborhood Hits	537	Shared Neighborhood Hits	156
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SPTA2_HUMAN
θ value	0.00102713 (rank : 35)	NC score	0.177387 (rank : 134)
Query Neighborhood Hits	389	Target Neighborhood Hits	888	Shared Neighborhood Hits	152
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ITSN1_HUMAN
θ value	0.00134147 (rank : 36)	NC score	0.281896 (rank : 83)
Query Neighborhood Hits	389	Target Neighborhood Hits	1757	Shared Neighborhood Hits	225
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3G2_MOUSE
θ value	0.00134147 (rank : 37)	NC score	0.395338 (rank : 22)
Query Neighborhood Hits	389	Target Neighborhood Hits	319	Shared Neighborhood Hits	154
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SNX18_HUMAN
θ value	0.00134147 (rank : 38)	NC score	0.312744 (rank : 64)
Query Neighborhood Hits	389	Target Neighborhood Hits	207	Shared Neighborhood Hits	124
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

FGD1_MOUSE
θ value	0.00175202 (rank : 39)	NC score	0.085673 (rank : 264)
Query Neighborhood Hits	389	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

M3K11_HUMAN
θ value	0.00175202 (rank : 40)	NC score	0.126856 (rank : 166)
Query Neighborhood Hits	389	Target Neighborhood Hits	1136	Shared Neighborhood Hits	177
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RHG04_HUMAN
θ value	0.00228821 (rank : 41)	NC score	0.238420 (rank : 105)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	138
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

AUTS2_HUMAN
θ value	0.00298849 (rank : 42)	NC score	0.100353 (rank : 215)
Query Neighborhood Hits	389	Target Neighborhood Hits	342	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

DNMBP_HUMAN
θ value	0.00298849 (rank : 43)	NC score	0.360237 (rank : 49)
Query Neighborhood Hits	389	Target Neighborhood Hits	413	Shared Neighborhood Hits	166
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_HUMAN
θ value	0.00298849 (rank : 44)	NC score	0.283812 (rank : 81)
Query Neighborhood Hits	389	Target Neighborhood Hits	1173	Shared Neighborhood Hits	180
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

OGFR_HUMAN
θ value	0.00298849 (rank : 45)	NC score	0.165643 (rank : 135)
Query Neighborhood Hits	389	Target Neighborhood Hits	1582	Shared Neighborhood Hits	194
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PACN2_HUMAN
θ value	0.00298849 (rank : 46)	NC score	0.382000 (rank : 33)
Query Neighborhood Hits	389	Target Neighborhood Hits	339	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

VAV_HUMAN
θ value	0.00298849 (rank : 47)	NC score	0.310023 (rank : 67)
Query Neighborhood Hits	389	Target Neighborhood Hits	452	Shared Neighborhood Hits	157
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NCF2_HUMAN
θ value	0.00390308 (rank : 48)	NC score	0.417971 (rank : 19)
Query Neighborhood Hits	389	Target Neighborhood Hits	229	Shared Neighborhood Hits	137
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PACN1_HUMAN
θ value	0.00390308 (rank : 49)	NC score	0.382437 (rank : 31)
Query Neighborhood Hits	389	Target Neighborhood Hits	320	Shared Neighborhood Hits	147
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.00390308 (rank : 50)	NC score	0.383442 (rank : 30)
Query Neighborhood Hits	389	Target Neighborhood Hits	283	Shared Neighborhood Hits	146
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ASPP1_HUMAN
θ value	0.00509761 (rank : 51)	NC score	0.273519 (rank : 92)
Query Neighborhood Hits	389	Target Neighborhood Hits	956	Shared Neighborhood Hits	171
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MYO1F_HUMAN
θ value	0.00509761 (rank : 52)	NC score	0.182888 (rank : 130)
Query Neighborhood Hits	389	Target Neighborhood Hits	275	Shared Neighborhood Hits	151
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NCF4_HUMAN
θ value	0.00509761 (rank : 53)	NC score	0.372518 (rank : 38)
Query Neighborhood Hits	389	Target Neighborhood Hits	161	Shared Neighborhood Hits	114
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN2_MOUSE
θ value	0.00509761 (rank : 54)	NC score	0.377965 (rank : 34)
Query Neighborhood Hits	389	Target Neighborhood Hits	382	Shared Neighborhood Hits	155
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_MOUSE
θ value	0.00509761 (rank : 55)	NC score	0.373521 (rank : 37)
Query Neighborhood Hits	389	Target Neighborhood Hits	380	Shared Neighborhood Hits	144
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

BAT2_HUMAN
θ value	0.00665767 (rank : 56)	NC score	0.158977 (rank : 140)
Query Neighborhood Hits	389	Target Neighborhood Hits	931	Shared Neighborhood Hits	129
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

GRAP_MOUSE
θ value	0.00665767 (rank : 57)	NC score	0.368450 (rank : 43)
Query Neighborhood Hits	389	Target Neighborhood Hits	309	Shared Neighborhood Hits	164
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PACN3_HUMAN
θ value	0.00665767 (rank : 58)	NC score	0.371201 (rank : 39)
Query Neighborhood Hits	389	Target Neighborhood Hits	385	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SH3G2_HUMAN
θ value	0.00665767 (rank : 59)	NC score	0.385029 (rank : 28)
Query Neighborhood Hits	389	Target Neighborhood Hits	324	Shared Neighborhood Hits	150
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

HCLS1_HUMAN
θ value	0.00869519 (rank : 60)	NC score	0.420400 (rank : 18)
Query Neighborhood Hits	389	Target Neighborhood Hits	358	Shared Neighborhood Hits	180
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MYO1F_MOUSE
θ value	0.00869519 (rank : 61)	NC score	0.180853 (rank : 131)
Query Neighborhood Hits	389	Target Neighborhood Hits	262	Shared Neighborhood Hits	148
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

VAV_MOUSE
θ value	0.00869519 (rank : 62)	NC score	0.305763 (rank : 71)
Query Neighborhood Hits	389	Target Neighborhood Hits	430	Shared Neighborhood Hits	155
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRAP2_MOUSE
θ value	0.0113563 (rank : 63)	NC score	0.382263 (rank : 32)
Query Neighborhood Hits	389	Target Neighborhood Hits	297	Shared Neighborhood Hits	163
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	0.0113563 (rank : 64)	NC score	0.362495 (rank : 46)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCF4_MOUSE
θ value	0.0113563 (rank : 65)	NC score	0.389128 (rank : 24)
Query Neighborhood Hits	389	Target Neighborhood Hits	177	Shared Neighborhood Hits	124
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	0.0113563 (rank : 66)	NC score	0.376828 (rank : 35)
Query Neighborhood Hits	389	Target Neighborhood Hits	312	Shared Neighborhood Hits	163
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CD2AP_HUMAN
θ value	0.0148317 (rank : 67)	NC score	0.445274 (rank : 15)
Query Neighborhood Hits	389	Target Neighborhood Hits	315	Shared Neighborhood Hits	157
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

FOG1_HUMAN
θ value	0.0148317 (rank : 68)	NC score	0.029734 (rank : 569)
Query Neighborhood Hits	389	Target Neighborhood Hits	981	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

RUSC2_MOUSE
θ value	0.0148317 (rank : 69)	NC score	0.214013 (rank : 116)
Query Neighborhood Hits	389	Target Neighborhood Hits	305	Shared Neighborhood Hits	96
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

WNK4_HUMAN
θ value	0.0148317 (rank : 70)	NC score	0.043678 (rank : 530)
Query Neighborhood Hits	389	Target Neighborhood Hits	1043	Shared Neighborhood Hits	79
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ASPP1_MOUSE
θ value	0.0193708 (rank : 71)	NC score	0.276306 (rank : 89)
Query Neighborhood Hits	389	Target Neighborhood Hits	1244	Shared Neighborhood Hits	233
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAT2_MOUSE
θ value	0.0193708 (rank : 72)	NC score	0.141748 (rank : 156)
Query Neighborhood Hits	389	Target Neighborhood Hits	947	Shared Neighborhood Hits	123
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

GRAP2_HUMAN
θ value	0.0193708 (rank : 73)	NC score	0.369924 (rank : 41)
Query Neighborhood Hits	389	Target Neighborhood Hits	304	Shared Neighborhood Hits	164
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ITSN2_MOUSE
θ value	0.0193708 (rank : 74)	NC score	0.267324 (rank : 93)
Query Neighborhood Hits	389	Target Neighborhood Hits	1371	Shared Neighborhood Hits	186
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ES8L2_HUMAN
θ value	0.0252991 (rank : 75)	NC score	0.229697 (rank : 107)
Query Neighborhood Hits	389	Target Neighborhood Hits	193	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

HXB4_MOUSE
θ value	0.0252991 (rank : 76)	NC score	0.020699 (rank : 596)
Query Neighborhood Hits	389	Target Neighborhood Hits	375	Shared Neighborhood Hits	21
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

M3K10_HUMAN
θ value	0.0330416 (rank : 77)	NC score	0.105476 (rank : 198)
Query Neighborhood Hits	389	Target Neighborhood Hits	1071	Shared Neighborhood Hits	154
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

LCP2_MOUSE
θ value	0.0431538 (rank : 78)	NC score	0.097939 (rank : 224)
Query Neighborhood Hits	389	Target Neighborhood Hits	177	Shared Neighborhood Hits	54
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

M3K9_HUMAN
θ value	0.0431538 (rank : 79)	NC score	0.113021 (rank : 178)
Query Neighborhood Hits	389	Target Neighborhood Hits	1123	Shared Neighborhood Hits	168
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRMS_MOUSE
θ value	0.0431538 (rank : 80)	NC score	0.067759 (rank : 349)
Query Neighborhood Hits	389	Target Neighborhood Hits	964	Shared Neighborhood Hits	103
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ABI2_HUMAN
θ value	0.0563607 (rank : 81)	NC score	0.391683 (rank : 23)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	170
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.0563607 (rank : 82)	NC score	0.383850 (rank : 29)
Query Neighborhood Hits	389	Target Neighborhood Hits	266	Shared Neighborhood Hits	152
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SH3G1_MOUSE
θ value	0.0563607 (rank : 83)	NC score	0.368990 (rank : 42)
Query Neighborhood Hits	389	Target Neighborhood Hits	291	Shared Neighborhood Hits	150
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SN1L2_HUMAN
θ value	0.0563607 (rank : 84)	NC score	0.022731 (rank : 589)
Query Neighborhood Hits	389	Target Neighborhood Hits	964	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SPTA1_HUMAN
θ value	0.0563607 (rank : 85)	NC score	0.160830 (rank : 138)
Query Neighborhood Hits	389	Target Neighborhood Hits	748	Shared Neighborhood Hits	143
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_MOUSE
θ value	0.0563607 (rank : 86)	NC score	0.399535 (rank : 21)
Query Neighborhood Hits	389	Target Neighborhood Hits	409	Shared Neighborhood Hits	178
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ES8L3_MOUSE
θ value	0.0736092 (rank : 87)	NC score	0.256038 (rank : 95)
Query Neighborhood Hits	389	Target Neighborhood Hits	168	Shared Neighborhood Hits	121
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HCLS1_MOUSE
θ value	0.0736092 (rank : 88)	NC score	0.406499 (rank : 20)
Query Neighborhood Hits	389	Target Neighborhood Hits	329	Shared Neighborhood Hits	176
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

RIMB1_HUMAN
θ value	0.0736092 (rank : 89)	NC score	0.179501 (rank : 133)
Query Neighborhood Hits	389	Target Neighborhood Hits	1479	Shared Neighborhood Hits	204
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRBS1_HUMAN
θ value	0.0736092 (rank : 90)	NC score	0.387267 (rank : 27)
Query Neighborhood Hits	389	Target Neighborhood Hits	396	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SYP2L_HUMAN
θ value	0.0736092 (rank : 91)	NC score	0.073475 (rank : 311)
Query Neighborhood Hits	389	Target Neighborhood Hits	400	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

CBP_HUMAN
θ value	0.0961366 (rank : 92)	NC score	0.100071 (rank : 217)
Query Neighborhood Hits	389	Target Neighborhood Hits	941	Shared Neighborhood Hits	126
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DNMBP_MOUSE
θ value	0.0961366 (rank : 93)	NC score	0.340747 (rank : 56)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	176
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NFH_MOUSE
θ value	0.0961366 (rank : 94)	NC score	0.072653 (rank : 317)
Query Neighborhood Hits	389	Target Neighborhood Hits	2247	Shared Neighborhood Hits	172
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NOXO1_HUMAN
θ value	0.0961366 (rank : 95)	NC score	0.204228 (rank : 119)
Query Neighborhood Hits	389	Target Neighborhood Hits	100	Shared Neighborhood Hits	76
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SHAN2_MOUSE
θ value	0.0961366 (rank : 96)	NC score	0.150981 (rank : 146)
Query Neighborhood Hits	389	Target Neighborhood Hits	446	Shared Neighborhood Hits	125
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ANK2_HUMAN
θ value	0.125558 (rank : 97)	NC score	0.057509 (rank : 439)
Query Neighborhood Hits	389	Target Neighborhood Hits	1615	Shared Neighborhood Hits	146
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ARHG7_HUMAN
θ value	0.125558 (rank : 98)	NC score	0.327708 (rank : 61)
Query Neighborhood Hits	389	Target Neighborhood Hits	347	Shared Neighborhood Hits	154
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	0.125558 (rank : 99)	NC score	0.326647 (rank : 62)
Query Neighborhood Hits	389	Target Neighborhood Hits	396	Shared Neighborhood Hits	157
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CN155_HUMAN
θ value	0.125558 (rank : 100)	NC score	0.113632 (rank : 175)
Query Neighborhood Hits	389	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CRKL_HUMAN
θ value	0.125558 (rank : 101)	NC score	0.337730 (rank : 59)
Query Neighborhood Hits	389	Target Neighborhood Hits	313	Shared Neighborhood Hits	161
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

EPS8_HUMAN
θ value	0.125558 (rank : 102)	NC score	0.203833 (rank : 121)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	97
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

NMDE3_MOUSE
θ value	0.125558 (rank : 103)	NC score	0.021954 (rank : 592)
Query Neighborhood Hits	389	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

RIMB2_HUMAN
θ value	0.125558 (rank : 104)	NC score	0.246906 (rank : 101)
Query Neighborhood Hits	389	Target Neighborhood Hits	263	Shared Neighborhood Hits	107
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SNX9_HUMAN
θ value	0.125558 (rank : 105)	NC score	0.218666 (rank : 111)
Query Neighborhood Hits	389	Target Neighborhood Hits	148	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

STAR8_HUMAN
θ value	0.125558 (rank : 106)	NC score	0.058697 (rank : 428)
Query Neighborhood Hits	389	Target Neighborhood Hits	216	Shared Neighborhood Hits	38
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CN032_HUMAN
θ value	0.163984 (rank : 107)	NC score	0.104130 (rank : 201)
Query Neighborhood Hits	389	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

ES8L2_MOUSE
θ value	0.163984 (rank : 108)	NC score	0.219961 (rank : 110)
Query Neighborhood Hits	389	Target Neighborhood Hits	169	Shared Neighborhood Hits	103
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NEBL_HUMAN
θ value	0.163984 (rank : 109)	NC score	0.284111 (rank : 80)
Query Neighborhood Hits	389	Target Neighborhood Hits	457	Shared Neighborhood Hits	135
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	0.163984 (rank : 110)	NC score	0.247530 (rank : 100)
Query Neighborhood Hits	389	Target Neighborhood Hits	420	Shared Neighborhood Hits	139
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SH3G3_HUMAN
θ value	0.163984 (rank : 111)	NC score	0.367403 (rank : 44)
Query Neighborhood Hits	389	Target Neighborhood Hits	222	Shared Neighborhood Hits	147
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRGP2_MOUSE
θ value	0.163984 (rank : 112)	NC score	0.189748 (rank : 123)
Query Neighborhood Hits	389	Target Neighborhood Hits	324	Shared Neighborhood Hits	132
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ASPP2_HUMAN
θ value	0.21417 (rank : 113)	NC score	0.216418 (rank : 113)
Query Neighborhood Hits	389	Target Neighborhood Hits	1156	Shared Neighborhood Hits	170
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

C1QBP_MOUSE
θ value	0.21417 (rank : 114)	NC score	0.047861 (rank : 519)
Query Neighborhood Hits	389	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O35658	Gene names	C1qbp, Gc1qbp
Domain Architecture
Description	Complement component 1 Q subcomponent-binding protein, mitochondrial precursor (Glycoprotein gC1qBP) (C1qBP) (GC1q-R protein).

CRK_HUMAN
θ value	0.21417 (rank : 115)	NC score	0.312112 (rank : 66)
Query Neighborhood Hits	389	Target Neighborhood Hits	308	Shared Neighborhood Hits	161
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GA2L2_MOUSE
θ value	0.21417 (rank : 116)	NC score	0.080090 (rank : 284)
Query Neighborhood Hits	389	Target Neighborhood Hits	395	Shared Neighborhood Hits	92
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GSCR1_HUMAN
θ value	0.21417 (rank : 117)	NC score	0.119223 (rank : 171)
Query Neighborhood Hits	389	Target Neighborhood Hits	674	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MLL2_HUMAN
θ value	0.21417 (rank : 118)	NC score	0.091290 (rank : 242)
Query Neighborhood Hits	389	Target Neighborhood Hits	1788	Shared Neighborhood Hits	146
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL4_HUMAN
θ value	0.21417 (rank : 119)	NC score	0.081765 (rank : 281)
Query Neighborhood Hits	389	Target Neighborhood Hits	722	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

RHG26_HUMAN
θ value	0.21417 (rank : 120)	NC score	0.186975 (rank : 125)
Query Neighborhood Hits	389	Target Neighborhood Hits	281	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TROAP_HUMAN
θ value	0.21417 (rank : 121)	NC score	0.128648 (rank : 163)
Query Neighborhood Hits	389	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

VAV2_HUMAN
θ value	0.21417 (rank : 122)	NC score	0.254590 (rank : 97)
Query Neighborhood Hits	389	Target Neighborhood Hits	453	Shared Neighborhood Hits	157
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

WASL_MOUSE
θ value	0.21417 (rank : 123)	NC score	0.095553 (rank : 229)
Query Neighborhood Hits	389	Target Neighborhood Hits	339	Shared Neighborhood Hits	56
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

AB1IP_HUMAN
θ value	0.279714 (rank : 124)	NC score	0.059396 (rank : 419)
Query Neighborhood Hits	389	Target Neighborhood Hits	213	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

ABI1_MOUSE
θ value	0.279714 (rank : 125)	NC score	0.352491 (rank : 51)
Query Neighborhood Hits	389	Target Neighborhood Hits	246	Shared Neighborhood Hits	145
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

NACAM_MOUSE
θ value	0.279714 (rank : 126)	NC score	0.145316 (rank : 152)
Query Neighborhood Hits	389	Target Neighborhood Hits	1866	Shared Neighborhood Hits	202
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

RIMB1_MOUSE
θ value	0.279714 (rank : 127)	NC score	0.144918 (rank : 153)
Query Neighborhood Hits	389	Target Neighborhood Hits	1376	Shared Neighborhood Hits	179
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SFPQ_MOUSE
θ value	0.279714 (rank : 128)	NC score	0.079827 (rank : 288)
Query Neighborhood Hits	389	Target Neighborhood Hits	958	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SPEG_HUMAN
θ value	0.279714 (rank : 129)	NC score	0.034471 (rank : 551)
Query Neighborhood Hits	389	Target Neighborhood Hits	1762	Shared Neighborhood Hits	130
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

FGD1_HUMAN
θ value	0.365318 (rank : 130)	NC score	0.080932 (rank : 283)
Query Neighborhood Hits	389	Target Neighborhood Hits	367	Shared Neighborhood Hits	55
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

HXB4_HUMAN
θ value	0.365318 (rank : 131)	NC score	0.018208 (rank : 603)
Query Neighborhood Hits	389	Target Neighborhood Hits	376	Shared Neighborhood Hits	23
SwissProt Accessions	P17483, Q9NTA0	Gene names	HOXB4, HOX2F
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2F) (Hox-2.6).

NOXO1_MOUSE
θ value	0.365318 (rank : 132)	NC score	0.257374 (rank : 94)
Query Neighborhood Hits	389	Target Neighborhood Hits	114	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_MOUSE
θ value	0.365318 (rank : 133)	NC score	0.307855 (rank : 70)
Query Neighborhood Hits	389	Target Neighborhood Hits	267	Shared Neighborhood Hits	140
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PCLO_HUMAN
θ value	0.365318 (rank : 134)	NC score	0.108452 (rank : 191)
Query Neighborhood Hits	389	Target Neighborhood Hits	2046	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SNX9_MOUSE
θ value	0.365318 (rank : 135)	NC score	0.204094 (rank : 120)
Query Neighborhood Hits	389	Target Neighborhood Hits	141	Shared Neighborhood Hits	80
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

TNKS1_HUMAN
θ value	0.365318 (rank : 136)	NC score	0.033195 (rank : 556)
Query Neighborhood Hits	389	Target Neighborhood Hits	477	Shared Neighborhood Hits	32
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

WBP11_HUMAN
θ value	0.365318 (rank : 137)	NC score	0.106911 (rank : 196)
Query Neighborhood Hits	389	Target Neighborhood Hits	354	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WNK2_HUMAN
θ value	0.365318 (rank : 138)	NC score	0.052968 (rank : 489)
Query Neighborhood Hits	389	Target Neighborhood Hits	1407	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

COG8_MOUSE
θ value	0.47712 (rank : 139)	NC score	0.061963 (rank : 394)
Query Neighborhood Hits	389	Target Neighborhood Hits	147	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

CRK_MOUSE
θ value	0.47712 (rank : 140)	NC score	0.328615 (rank : 60)
Query Neighborhood Hits	389	Target Neighborhood Hits	314	Shared Neighborhood Hits	162
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAK_MOUSE
θ value	0.47712 (rank : 141)	NC score	0.046056 (rank : 524)
Query Neighborhood Hits	389	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC30	Gene names	Dak
Domain Architecture	No domain graphic available
Description	Dihydroxyacetone kinase (EC 2.7.1.29) (Glycerone kinase) (DHA kinase).

DLG5_HUMAN
θ value	0.47712 (rank : 142)	NC score	0.056601 (rank : 451)
Query Neighborhood Hits	389	Target Neighborhood Hits	1088	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ES8L1_HUMAN
θ value	0.47712 (rank : 143)	NC score	0.188537 (rank : 124)
Query Neighborhood Hits	389	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

GGN_HUMAN
θ value	0.47712 (rank : 144)	NC score	0.100611 (rank : 213)
Query Neighborhood Hits	389	Target Neighborhood Hits	269	Shared Neighborhood Hits	59
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

LASP1_HUMAN
θ value	0.47712 (rank : 145)	NC score	0.291997 (rank : 75)
Query Neighborhood Hits	389	Target Neighborhood Hits	293	Shared Neighborhood Hits	134
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.47712 (rank : 146)	NC score	0.289278 (rank : 78)
Query Neighborhood Hits	389	Target Neighborhood Hits	297	Shared Neighborhood Hits	132
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MYO1E_HUMAN
θ value	0.47712 (rank : 147)	NC score	0.161812 (rank : 136)
Query Neighborhood Hits	389	Target Neighborhood Hits	293	Shared Neighborhood Hits	149
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PTN23_MOUSE
θ value	0.47712 (rank : 148)	NC score	0.050708 (rank : 510)
Query Neighborhood Hits	389	Target Neighborhood Hits	726	Shared Neighborhood Hits	86
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SON_HUMAN
θ value	0.47712 (rank : 149)	NC score	0.136992 (rank : 160)
Query Neighborhood Hits	389	Target Neighborhood Hits	1568	Shared Neighborhood Hits	176
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SRGP2_HUMAN
θ value	0.47712 (rank : 150)	NC score	0.183862 (rank : 128)
Query Neighborhood Hits	389	Target Neighborhood Hits	331	Shared Neighborhood Hits	133
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SYNJ1_HUMAN
θ value	0.47712 (rank : 151)	NC score	0.074500 (rank : 302)
Query Neighborhood Hits	389	Target Neighborhood Hits	498	Shared Neighborhood Hits	85
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

VAV2_MOUSE
θ value	0.47712 (rank : 152)	NC score	0.253700 (rank : 98)
Query Neighborhood Hits	389	Target Neighborhood Hits	456	Shared Neighborhood Hits	157
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

BCL9_HUMAN
θ value	0.62314 (rank : 153)	NC score	0.112638 (rank : 182)
Query Neighborhood Hits	389	Target Neighborhood Hits	1008	Shared Neighborhood Hits	144
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BRD4_HUMAN
θ value	0.62314 (rank : 154)	NC score	0.071617 (rank : 325)
Query Neighborhood Hits	389	Target Neighborhood Hits	851	Shared Neighborhood Hits	82
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

FETUA_HUMAN
θ value	0.62314 (rank : 155)	NC score	0.036950 (rank : 546)
Query Neighborhood Hits	389	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P02765, O14961, O14962, Q9P152	Gene names	AHSG, FETUA
Domain Architecture
Description	Alpha-2-HS-glycoprotein precursor (Fetuin-A) (Alpha-2-Z-globulin) (Ba- alpha-2-glycoprotein) [Contains: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B].

HXB13_MOUSE
θ value	0.62314 (rank : 156)	NC score	0.016058 (rank : 608)
Query Neighborhood Hits	389	Target Neighborhood Hits	384	Shared Neighborhood Hits	18
SwissProt Accessions	P70321, Q80Y12	Gene names	Hoxb13
Domain Architecture
Description	Homeobox protein Hox-B13.

IRS2_HUMAN
θ value	0.62314 (rank : 157)	NC score	0.052763 (rank : 491)
Query Neighborhood Hits	389	Target Neighborhood Hits	262	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

MINK1_MOUSE
θ value	0.62314 (rank : 158)	NC score	0.027459 (rank : 572)
Query Neighborhood Hits	389	Target Neighborhood Hits	1451	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

NCF1_HUMAN
θ value	0.62314 (rank : 159)	NC score	0.352801 (rank : 50)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	132
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

OSTF1_MOUSE
θ value	0.62314 (rank : 160)	NC score	0.276854 (rank : 88)
Query Neighborhood Hits	389	Target Neighborhood Hits	467	Shared Neighborhood Hits	156
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PRGC2_HUMAN
θ value	0.62314 (rank : 161)	NC score	0.059032 (rank : 424)
Query Neighborhood Hits	389	Target Neighborhood Hits	272	Shared Neighborhood Hits	48
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

SF01_HUMAN
θ value	0.62314 (rank : 162)	NC score	0.090764 (rank : 245)
Query Neighborhood Hits	389	Target Neighborhood Hits	287	Shared Neighborhood Hits	53
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SRC_HUMAN
θ value	0.62314 (rank : 163)	NC score	0.105249 (rank : 199)
Query Neighborhood Hits	389	Target Neighborhood Hits	1058	Shared Neighborhood Hits	165
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.62314 (rank : 164)	NC score	0.091097 (rank : 243)
Query Neighborhood Hits	389	Target Neighborhood Hits	1033	Shared Neighborhood Hits	146
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

STAM2_MOUSE
θ value	0.62314 (rank : 165)	NC score	0.312563 (rank : 65)
Query Neighborhood Hits	389	Target Neighborhood Hits	285	Shared Neighborhood Hits	153
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

YLPM1_HUMAN
θ value	0.62314 (rank : 166)	NC score	0.088083 (rank : 252)
Query Neighborhood Hits	389	Target Neighborhood Hits	670	Shared Neighborhood Hits	80
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ABI1_HUMAN
θ value	0.813845 (rank : 167)	NC score	0.340094 (rank : 58)
Query Neighborhood Hits	389	Target Neighborhood Hits	257	Shared Neighborhood Hits	155
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABL1_HUMAN
θ value	0.813845 (rank : 168)	NC score	0.074432 (rank : 303)
Query Neighborhood Hits	389	Target Neighborhood Hits	1220	Shared Neighborhood Hits	152
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.813845 (rank : 169)	NC score	0.075371 (rank : 298)
Query Neighborhood Hits	389	Target Neighborhood Hits	1178	Shared Neighborhood Hits	144
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BRD4_MOUSE
θ value	0.813845 (rank : 170)	NC score	0.070355 (rank : 334)
Query Neighborhood Hits	389	Target Neighborhood Hits	845	Shared Neighborhood Hits	77
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CSKI1_HUMAN
θ value	0.813845 (rank : 171)	NC score	0.066027 (rank : 360)
Query Neighborhood Hits	389	Target Neighborhood Hits	997	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DAAM2_MOUSE
θ value	0.813845 (rank : 172)	NC score	0.040800 (rank : 535)
Query Neighborhood Hits	389	Target Neighborhood Hits	371	Shared Neighborhood Hits	37
SwissProt Accessions	Q80U19, Q810J5	Gene names	Daam2, Kiaa0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DUS8_HUMAN
θ value	0.813845 (rank : 173)	NC score	0.028315 (rank : 570)
Query Neighborhood Hits	389	Target Neighborhood Hits	161	Shared Neighborhood Hits	27
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

EP300_HUMAN
θ value	0.813845 (rank : 174)	NC score	0.087244 (rank : 255)
Query Neighborhood Hits	389	Target Neighborhood Hits	821	Shared Neighborhood Hits	97
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

FOG1_MOUSE
θ value	0.813845 (rank : 175)	NC score	0.033573 (rank : 554)
Query Neighborhood Hits	389	Target Neighborhood Hits	1237	Shared Neighborhood Hits	96
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

IQEC2_HUMAN
θ value	0.813845 (rank : 176)	NC score	0.048565 (rank : 517)
Query Neighborhood Hits	389	Target Neighborhood Hits	403	Shared Neighborhood Hits	61
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	0.813845 (rank : 177)	NC score	0.049086 (rank : 516)
Query Neighborhood Hits	389	Target Neighborhood Hits	417	Shared Neighborhood Hits	62
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

LR37A_HUMAN
θ value	0.813845 (rank : 178)	NC score	0.067829 (rank : 348)
Query Neighborhood Hits	389	Target Neighborhood Hits	720	Shared Neighborhood Hits	76
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

PP16A_MOUSE
θ value	0.813845 (rank : 179)	NC score	0.036784 (rank : 547)
Query Neighborhood Hits	389	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

REPS2_MOUSE
θ value	0.813845 (rank : 180)	NC score	0.067686 (rank : 350)
Query Neighborhood Hits	389	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RIMB2_MOUSE
θ value	0.813845 (rank : 181)	NC score	0.240133 (rank : 103)
Query Neighborhood Hits	389	Target Neighborhood Hits	246	Shared Neighborhood Hits	100
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RP3A_MOUSE
θ value	0.813845 (rank : 182)	NC score	0.046934 (rank : 522)
Query Neighborhood Hits	389	Target Neighborhood Hits	510	Shared Neighborhood Hits	82
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SH3G3_MOUSE
θ value	0.813845 (rank : 183)	NC score	0.363281 (rank : 45)
Query Neighborhood Hits	389	Target Neighborhood Hits	236	Shared Neighborhood Hits	151
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ARHG9_MOUSE
θ value	1.06291 (rank : 184)	NC score	0.226128 (rank : 109)
Query Neighborhood Hits	389	Target Neighborhood Hits	234	Shared Neighborhood Hits	131
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CCD1A_HUMAN
θ value	1.06291 (rank : 185)	NC score	0.047365 (rank : 521)
Query Neighborhood Hits	389	Target Neighborhood Hits	123	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P1N0, Q7Z435, Q86XV0, Q8NF89, Q9H603, Q9NXI1	Gene names	CC2D1A
Domain Architecture	No domain graphic available
Description	Coiled-coil and C2 domain-containing protein 1A (Five repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B- activating protein 023N).

EPS8_MOUSE
θ value	1.06291 (rank : 186)	NC score	0.207898 (rank : 117)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_MOUSE
θ value	1.06291 (rank : 187)	NC score	0.186512 (rank : 126)
Query Neighborhood Hits	389	Target Neighborhood Hits	143	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FMNL_HUMAN
θ value	1.06291 (rank : 188)	NC score	0.074321 (rank : 304)
Query Neighborhood Hits	389	Target Neighborhood Hits	529	Shared Neighborhood Hits	70
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

LIMD1_MOUSE
θ value	1.06291 (rank : 189)	NC score	0.027077 (rank : 574)
Query Neighborhood Hits	389	Target Neighborhood Hits	291	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

MATK_HUMAN
θ value	1.06291 (rank : 190)	NC score	0.055595 (rank : 464)
Query Neighborhood Hits	389	Target Neighborhood Hits	954	Shared Neighborhood Hits	79
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MEF2B_MOUSE
θ value	1.06291 (rank : 191)	NC score	0.054395 (rank : 475)
Query Neighborhood Hits	389	Target Neighborhood Hits	218	Shared Neighborhood Hits	47
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

MINK1_HUMAN
θ value	1.06291 (rank : 192)	NC score	0.027055 (rank : 575)
Query Neighborhood Hits	389	Target Neighborhood Hits	1477	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MUC7_HUMAN
θ value	1.06291 (rank : 193)	NC score	0.110822 (rank : 186)
Query Neighborhood Hits	389	Target Neighborhood Hits	538	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

PDC6I_HUMAN
θ value	1.06291 (rank : 194)	NC score	0.058880 (rank : 427)
Query Neighborhood Hits	389	Target Neighborhood Hits	278	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

SH3G1_HUMAN
θ value	1.06291 (rank : 195)	NC score	0.345175 (rank : 52)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	149
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SRC8_HUMAN
θ value	1.06291 (rank : 196)	NC score	0.362266 (rank : 47)
Query Neighborhood Hits	389	Target Neighborhood Hits	269	Shared Neighborhood Hits	150
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	1.06291 (rank : 197)	NC score	0.362101 (rank : 48)
Query Neighborhood Hits	389	Target Neighborhood Hits	292	Shared Neighborhood Hits	151
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

T22D4_HUMAN
θ value	1.06291 (rank : 198)	NC score	0.068226 (rank : 343)
Query Neighborhood Hits	389	Target Neighborhood Hits	403	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

T240L_HUMAN
θ value	1.06291 (rank : 199)	NC score	0.027641 (rank : 571)
Query Neighborhood Hits	389	Target Neighborhood Hits	132	Shared Neighborhood Hits	17
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

TACT_HUMAN
θ value	1.06291 (rank : 200)	NC score	0.044443 (rank : 528)
Query Neighborhood Hits	389	Target Neighborhood Hits	100	Shared Neighborhood Hits	10
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

TENS4_HUMAN
θ value	1.06291 (rank : 201)	NC score	0.062669 (rank : 391)
Query Neighborhood Hits	389	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

ADA19_HUMAN
θ value	1.38821 (rank : 202)	NC score	0.008904 (rank : 621)
Query Neighborhood Hits	389	Target Neighborhood Hits	381	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ARHG9_HUMAN
θ value	1.38821 (rank : 203)	NC score	0.227309 (rank : 108)
Query Neighborhood Hits	389	Target Neighborhood Hits	235	Shared Neighborhood Hits	132
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

CABL2_HUMAN
θ value	1.38821 (rank : 204)	NC score	0.030329 (rank : 567)
Query Neighborhood Hits	389	Target Neighborhood Hits	84	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

FA61A_MOUSE
θ value	1.38821 (rank : 205)	NC score	0.035488 (rank : 550)
Query Neighborhood Hits	389	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K2F8, Q9CTG8	Gene names	Fam61a
Domain Architecture	No domain graphic available
Description	Protein FAM61A.

FMN2_HUMAN
θ value	1.38821 (rank : 206)	NC score	0.081735 (rank : 282)
Query Neighborhood Hits	389	Target Neighborhood Hits	484	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FYN_HUMAN
θ value	1.38821 (rank : 207)	NC score	0.102468 (rank : 204)
Query Neighborhood Hits	389	Target Neighborhood Hits	1078	Shared Neighborhood Hits	165
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	1.38821 (rank : 208)	NC score	0.105206 (rank : 200)
Query Neighborhood Hits	389	Target Neighborhood Hits	1073	Shared Neighborhood Hits	166
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

KBTBB_HUMAN
θ value	1.38821 (rank : 209)	NC score	0.018460 (rank : 601)
Query Neighborhood Hits	389	Target Neighborhood Hits	195	Shared Neighborhood Hits	17
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

LYN_MOUSE
θ value	1.38821 (rank : 210)	NC score	0.084580 (rank : 272)
Query Neighborhood Hits	389	Target Neighborhood Hits	1023	Shared Neighborhood Hits	144
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MAGE1_HUMAN
θ value	1.38821 (rank : 211)	NC score	0.107295 (rank : 194)
Query Neighborhood Hits	389	Target Neighborhood Hits	1389	Shared Neighborhood Hits	172
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

NCF1_MOUSE
θ value	1.38821 (rank : 212)	NC score	0.344280 (rank : 54)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	137
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NPHP1_HUMAN
θ value	1.38821 (rank : 213)	NC score	0.275548 (rank : 91)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	133
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PHC2_HUMAN
θ value	1.38821 (rank : 214)	NC score	0.084083 (rank : 273)
Query Neighborhood Hits	389	Target Neighborhood Hits	388	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

PP4R1_MOUSE
θ value	1.38821 (rank : 215)	NC score	0.023655 (rank : 584)
Query Neighborhood Hits	389	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

PRRT3_HUMAN
θ value	1.38821 (rank : 216)	NC score	0.161083 (rank : 137)
Query Neighborhood Hits	389	Target Neighborhood Hits	998	Shared Neighborhood Hits	170
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RAPH1_HUMAN
θ value	1.38821 (rank : 217)	NC score	0.126412 (rank : 167)
Query Neighborhood Hits	389	Target Neighborhood Hits	593	Shared Neighborhood Hits	98
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SAPS1_HUMAN
θ value	1.38821 (rank : 218)	NC score	0.103461 (rank : 203)
Query Neighborhood Hits	389	Target Neighborhood Hits	704	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SEM4G_HUMAN
θ value	1.38821 (rank : 219)	NC score	0.006910 (rank : 625)
Query Neighborhood Hits	389	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NTN9, Q9HCF3	Gene names	SEMA4G, KIAA1619
Domain Architecture
Description	Semaphorin-4G precursor.

SPN90_HUMAN
θ value	1.38821 (rank : 220)	NC score	0.139582 (rank : 157)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STAM2_HUMAN
θ value	1.38821 (rank : 221)	NC score	0.291222 (rank : 77)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	151
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

WBP11_MOUSE
θ value	1.38821 (rank : 222)	NC score	0.101708 (rank : 211)
Query Neighborhood Hits	389	Target Neighborhood Hits	362	Shared Neighborhood Hits	60
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

ABI3_MOUSE
θ value	1.81305 (rank : 223)	NC score	0.283305 (rank : 82)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CDAN1_HUMAN
θ value	1.81305 (rank : 224)	NC score	0.069683 (rank : 335)
Query Neighborhood Hits	389	Target Neighborhood Hits	92	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IWY9, Q7Z7L5, Q969N3	Gene names	CDAN1
Domain Architecture	No domain graphic available
Description	Codanin-1.

CI079_HUMAN
θ value	1.81305 (rank : 225)	NC score	0.058674 (rank : 429)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CNTRB_HUMAN
θ value	1.81305 (rank : 226)	NC score	0.024261 (rank : 582)
Query Neighborhood Hits	389	Target Neighborhood Hits	690	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

ENAH_MOUSE
θ value	1.81305 (rank : 227)	NC score	0.092170 (rank : 238)
Query Neighborhood Hits	389	Target Neighborhood Hits	919	Shared Neighborhood Hits	99
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ETV5_MOUSE
θ value	1.81305 (rank : 228)	NC score	0.032322 (rank : 558)
Query Neighborhood Hits	389	Target Neighborhood Hits	328	Shared Neighborhood Hits	65
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

HIC1_MOUSE
θ value	1.81305 (rank : 229)	NC score	-0.003123 (rank : 637)
Query Neighborhood Hits	389	Target Neighborhood Hits	863	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

JPH2_HUMAN
θ value	1.81305 (rank : 230)	NC score	0.055793 (rank : 459)
Query Neighborhood Hits	389	Target Neighborhood Hits	639	Shared Neighborhood Hits	114
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

MEF2B_HUMAN
θ value	1.81305 (rank : 231)	NC score	0.041851 (rank : 531)
Query Neighborhood Hits	389	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

MYO15_HUMAN
θ value	1.81305 (rank : 232)	NC score	0.052724 (rank : 493)
Query Neighborhood Hits	389	Target Neighborhood Hits	671	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NFAC4_HUMAN
θ value	1.81305 (rank : 233)	NC score	0.031922 (rank : 560)
Query Neighborhood Hits	389	Target Neighborhood Hits	165	Shared Neighborhood Hits	31
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

RERE_HUMAN
θ value	1.81305 (rank : 234)	NC score	0.089476 (rank : 248)
Query Neighborhood Hits	389	Target Neighborhood Hits	779	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SRMS_HUMAN
θ value	1.81305 (rank : 235)	NC score	0.058467 (rank : 431)
Query Neighborhood Hits	389	Target Neighborhood Hits	946	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SYNJ1_MOUSE
θ value	1.81305 (rank : 236)	NC score	0.068347 (rank : 342)
Query Neighborhood Hits	389	Target Neighborhood Hits	516	Shared Neighborhood Hits	89
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SYNPO_MOUSE
θ value	1.81305 (rank : 237)	NC score	0.054030 (rank : 479)
Query Neighborhood Hits	389	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TAF4_HUMAN
θ value	1.81305 (rank : 238)	NC score	0.119298 (rank : 169)
Query Neighborhood Hits	389	Target Neighborhood Hits	687	Shared Neighborhood Hits	94
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

VAV3_HUMAN
θ value	1.81305 (rank : 239)	NC score	0.241345 (rank : 102)
Query Neighborhood Hits	389	Target Neighborhood Hits	398	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ZIM10_HUMAN
θ value	1.81305 (rank : 240)	NC score	0.054361 (rank : 476)
Query Neighborhood Hits	389	Target Neighborhood Hits	577	Shared Neighborhood Hits	91
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZO1_MOUSE
θ value	1.81305 (rank : 241)	NC score	0.039323 (rank : 538)
Query Neighborhood Hits	389	Target Neighborhood Hits	453	Shared Neighborhood Hits	47
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_HUMAN
θ value	1.81305 (rank : 242)	NC score	0.037831 (rank : 545)
Query Neighborhood Hits	389	Target Neighborhood Hits	289	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ABI3_HUMAN
θ value	2.36792 (rank : 243)	NC score	0.281121 (rank : 84)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	134
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG6_MOUSE
θ value	2.36792 (rank : 244)	NC score	0.287357 (rank : 79)
Query Neighborhood Hits	389	Target Neighborhood Hits	394	Shared Neighborhood Hits	149
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

BTK_HUMAN
θ value	2.36792 (rank : 245)	NC score	0.095492 (rank : 230)
Query Neighborhood Hits	389	Target Neighborhood Hits	1026	Shared Neighborhood Hits	159
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CRSP2_HUMAN
θ value	2.36792 (rank : 246)	NC score	0.086208 (rank : 262)
Query Neighborhood Hits	389	Target Neighborhood Hits	380	Shared Neighborhood Hits	82
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

DIAP1_MOUSE
θ value	2.36792 (rank : 247)	NC score	0.047396 (rank : 520)
Query Neighborhood Hits	389	Target Neighborhood Hits	839	Shared Neighborhood Hits	62
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

DYN2_MOUSE
θ value	2.36792 (rank : 248)	NC score	0.016371 (rank : 605)
Query Neighborhood Hits	389	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

ES8L3_HUMAN
θ value	2.36792 (rank : 249)	NC score	0.206547 (rank : 118)
Query Neighborhood Hits	389	Target Neighborhood Hits	206	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HCK_HUMAN
θ value	2.36792 (rank : 250)	NC score	0.093347 (rank : 237)
Query Neighborhood Hits	389	Target Neighborhood Hits	1035	Shared Neighborhood Hits	152
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

IL16_HUMAN
θ value	2.36792 (rank : 251)	NC score	0.022297 (rank : 591)
Query Neighborhood Hits	389	Target Neighborhood Hits	207	Shared Neighborhood Hits	22
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

KLF13_MOUSE
θ value	2.36792 (rank : 252)	NC score	-0.002775 (rank : 636)
Query Neighborhood Hits	389	Target Neighborhood Hits	757	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJZ6, Q9ESX3, Q9JHF8	Gene names	Klf13, Bteb3, Fklf2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Erythroid transcription factor FKLF-2).

LYN_HUMAN
θ value	2.36792 (rank : 253)	NC score	0.083964 (rank : 275)
Query Neighborhood Hits	389	Target Neighborhood Hits	1022	Shared Neighborhood Hits	144
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYST3_HUMAN
θ value	2.36792 (rank : 254)	NC score	0.039294 (rank : 539)
Query Neighborhood Hits	389	Target Neighborhood Hits	772	Shared Neighborhood Hits	56
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

ODPX_MOUSE
θ value	2.36792 (rank : 255)	NC score	0.019218 (rank : 598)
Query Neighborhood Hits	389	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

OSTF1_HUMAN
θ value	2.36792 (rank : 256)	NC score	0.276147 (rank : 90)
Query Neighborhood Hits	389	Target Neighborhood Hits	466	Shared Neighborhood Hits	155
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PGCB_HUMAN
θ value	2.36792 (rank : 257)	NC score	0.013677 (rank : 613)
Query Neighborhood Hits	389	Target Neighborhood Hits	478	Shared Neighborhood Hits	29
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

S23IP_HUMAN
θ value	2.36792 (rank : 258)	NC score	0.039642 (rank : 537)
Query Neighborhood Hits	389	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

SF01_MOUSE
θ value	2.36792 (rank : 259)	NC score	0.078282 (rank : 291)
Query Neighborhood Hits	389	Target Neighborhood Hits	240	Shared Neighborhood Hits	43
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

TACC2_HUMAN
θ value	2.36792 (rank : 260)	NC score	0.037900 (rank : 543)
Query Neighborhood Hits	389	Target Neighborhood Hits	856	Shared Neighborhood Hits	73
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TAOK2_HUMAN
θ value	2.36792 (rank : 261)	NC score	0.021562 (rank : 594)
Query Neighborhood Hits	389	Target Neighborhood Hits	1172	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

WASF4_HUMAN
θ value	2.36792 (rank : 262)	NC score	0.065317 (rank : 369)
Query Neighborhood Hits	389	Target Neighborhood Hits	282	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

BSN_MOUSE
θ value	3.0926 (rank : 263)	NC score	0.112427 (rank : 183)
Query Neighborhood Hits	389	Target Neighborhood Hits	2057	Shared Neighborhood Hits	196
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CN032_MOUSE
θ value	3.0926 (rank : 264)	NC score	0.097441 (rank : 225)
Query Neighborhood Hits	389	Target Neighborhood Hits	233	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

DVL2_MOUSE
θ value	3.0926 (rank : 265)	NC score	0.022431 (rank : 590)
Query Neighborhood Hits	389	Target Neighborhood Hits	233	Shared Neighborhood Hits	30
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

ENAH_HUMAN
θ value	3.0926 (rank : 266)	NC score	0.056341 (rank : 453)
Query Neighborhood Hits	389	Target Neighborhood Hits	784	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

HCK_MOUSE
θ value	3.0926 (rank : 267)	NC score	0.091414 (rank : 241)
Query Neighborhood Hits	389	Target Neighborhood Hits	1029	Shared Neighborhood Hits	153
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HPS4_HUMAN
θ value	3.0926 (rank : 268)	NC score	0.020706 (rank : 595)
Query Neighborhood Hits	389	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

JIP1_MOUSE
θ value	3.0926 (rank : 269)	NC score	0.086959 (rank : 257)
Query Neighborhood Hits	389	Target Neighborhood Hits	259	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NEU1_MOUSE
θ value	3.0926 (rank : 270)	NC score	0.018878 (rank : 599)
Query Neighborhood Hits	389	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	P35454	Gene names	Oxt
Domain Architecture
Description	Oxytocin-neurophysin 1 precursor (OT-NPI) [Contains: Oxytocin (Ocytocin); Neurophysin 1].

P85A_MOUSE
θ value	3.0926 (rank : 271)	NC score	0.118318 (rank : 172)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	100
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	3.0926 (rank : 272)	NC score	0.101089 (rank : 212)
Query Neighborhood Hits	389	Target Neighborhood Hits	543	Shared Neighborhood Hits	81
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCQAP_HUMAN
θ value	3.0926 (rank : 273)	NC score	0.063624 (rank : 380)
Query Neighborhood Hits	389	Target Neighborhood Hits	549	Shared Neighborhood Hits	64
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

RIN3_MOUSE
θ value	3.0926 (rank : 274)	NC score	0.043889 (rank : 529)
Query Neighborhood Hits	389	Target Neighborhood Hits	239	Shared Neighborhood Hits	41
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

S3TC1_HUMAN
θ value	3.0926 (rank : 275)	NC score	0.055752 (rank : 460)
Query Neighborhood Hits	389	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

SPTA1_MOUSE
θ value	3.0926 (rank : 276)	NC score	0.149744 (rank : 148)
Query Neighborhood Hits	389	Target Neighborhood Hits	675	Shared Neighborhood Hits	142
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VMD2_HUMAN
θ value	3.0926 (rank : 277)	NC score	0.014075 (rank : 611)
Query Neighborhood Hits	389	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	O76090, O75904, Q8IUR9, Q8IZ80	Gene names	VMD2
Domain Architecture
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2) (TU15B).

WASF2_HUMAN
θ value	3.0926 (rank : 278)	NC score	0.071049 (rank : 329)
Query Neighborhood Hits	389	Target Neighborhood Hits	280	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WASL_HUMAN
θ value	3.0926 (rank : 279)	NC score	0.085417 (rank : 267)
Query Neighborhood Hits	389	Target Neighborhood Hits	312	Shared Neighborhood Hits	56
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

YES_HUMAN
θ value	3.0926 (rank : 280)	NC score	0.101838 (rank : 209)
Query Neighborhood Hits	389	Target Neighborhood Hits	1059	Shared Neighborhood Hits	160
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	3.0926 (rank : 281)	NC score	0.102189 (rank : 207)
Query Neighborhood Hits	389	Target Neighborhood Hits	1052	Shared Neighborhood Hits	160
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZO2_MOUSE
θ value	3.0926 (rank : 282)	NC score	0.038288 (rank : 542)
Query Neighborhood Hits	389	Target Neighborhood Hits	296	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ANR11_HUMAN
θ value	4.03905 (rank : 283)	NC score	0.045298 (rank : 527)
Query Neighborhood Hits	389	Target Neighborhood Hits	1289	Shared Neighborhood Hits	107
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

APS_HUMAN
θ value	4.03905 (rank : 284)	NC score	0.077755 (rank : 293)
Query Neighborhood Hits	389	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

DAAM2_HUMAN
θ value	4.03905 (rank : 285)	NC score	0.039245 (rank : 540)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	34
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DAB2_MOUSE
θ value	4.03905 (rank : 286)	NC score	0.030985 (rank : 563)
Query Neighborhood Hits	389	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

DAK_HUMAN
θ value	4.03905 (rank : 287)	NC score	0.036349 (rank : 549)
Query Neighborhood Hits	389	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q3LXA3, Q53EQ9, Q9BVA7, Q9H895	Gene names	DAK
Domain Architecture	No domain graphic available
Description	Dihydroxyacetone kinase (EC 2.7.1.29) (Glycerone kinase) (DHA kinase).

DCP1B_HUMAN
θ value	4.03905 (rank : 288)	NC score	0.030573 (rank : 564)
Query Neighborhood Hits	389	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IZD4, Q86XH9, Q96BP8, Q96MZ8	Gene names	DCP1B
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1B (EC 3.-.-.-).

DIAP1_HUMAN
θ value	4.03905 (rank : 289)	NC score	0.059014 (rank : 426)
Query Neighborhood Hits	389	Target Neighborhood Hits	784	Shared Neighborhood Hits	69
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

ESX1L_HUMAN
θ value	4.03905 (rank : 290)	NC score	0.024514 (rank : 580)
Query Neighborhood Hits	389	Target Neighborhood Hits	498	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

HXD3_HUMAN
θ value	4.03905 (rank : 291)	NC score	0.014087 (rank : 610)
Query Neighborhood Hits	389	Target Neighborhood Hits	433	Shared Neighborhood Hits	27
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

HXD3_MOUSE
θ value	4.03905 (rank : 292)	NC score	0.013090 (rank : 614)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	27
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

LDB3_MOUSE
θ value	4.03905 (rank : 293)	NC score	0.045917 (rank : 525)
Query Neighborhood Hits	389	Target Neighborhood Hits	510	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LTBP4_MOUSE
θ value	4.03905 (rank : 294)	NC score	0.004472 (rank : 628)
Query Neighborhood Hits	389	Target Neighborhood Hits	607	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MAGD4_HUMAN
θ value	4.03905 (rank : 295)	NC score	0.022750 (rank : 588)
Query Neighborhood Hits	389	Target Neighborhood Hits	338	Shared Neighborhood Hits	50
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

MLL3_HUMAN
θ value	4.03905 (rank : 296)	NC score	0.099165 (rank : 220)
Query Neighborhood Hits	389	Target Neighborhood Hits	1644	Shared Neighborhood Hits	164
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MYST3_MOUSE
θ value	4.03905 (rank : 297)	NC score	0.033903 (rank : 553)
Query Neighborhood Hits	389	Target Neighborhood Hits	688	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

P85A_HUMAN
θ value	4.03905 (rank : 298)	NC score	0.112824 (rank : 180)
Query Neighborhood Hits	389	Target Neighborhood Hits	479	Shared Neighborhood Hits	95
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_MOUSE
θ value	4.03905 (rank : 299)	NC score	0.094687 (rank : 233)
Query Neighborhood Hits	389	Target Neighborhood Hits	519	Shared Neighborhood Hits	77
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PAIP1_HUMAN
θ value	4.03905 (rank : 300)	NC score	0.025258 (rank : 578)
Query Neighborhood Hits	389	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

PCBP4_HUMAN
θ value	4.03905 (rank : 301)	NC score	0.032936 (rank : 557)
Query Neighborhood Hits	389	Target Neighborhood Hits	49	Shared Neighborhood Hits	7
SwissProt Accessions	P57723, Q96AH7	Gene names	PCBP4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

RAD9B_MOUSE
θ value	4.03905 (rank : 302)	NC score	0.016316 (rank : 606)
Query Neighborhood Hits	389	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q6WBX7	Gene names	Rad9b
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint control protein RAD9B homolog (RAD9 homolog B) (mRAD9B).

REPS2_HUMAN
θ value	4.03905 (rank : 303)	NC score	0.062761 (rank : 389)
Query Neighborhood Hits	389	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SNX15_HUMAN
θ value	4.03905 (rank : 304)	NC score	0.021623 (rank : 593)
Query Neighborhood Hits	389	Target Neighborhood Hits	50	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRS6, Q9NRS5	Gene names	SNX15
Domain Architecture
Description	Sorting nexin-15.

SOX30_MOUSE
θ value	4.03905 (rank : 305)	NC score	0.036360 (rank : 548)
Query Neighborhood Hits	389	Target Neighborhood Hits	374	Shared Neighborhood Hits	73
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

TARA_HUMAN
θ value	4.03905 (rank : 306)	NC score	0.060134 (rank : 413)
Query Neighborhood Hits	389	Target Neighborhood Hits	1626	Shared Neighborhood Hits	144
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TBX18_MOUSE
θ value	4.03905 (rank : 307)	NC score	0.005873 (rank : 626)
Query Neighborhood Hits	389	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

TRPV1_MOUSE
θ value	4.03905 (rank : 308)	NC score	0.009532 (rank : 620)
Query Neighborhood Hits	389	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

VAV3_MOUSE
θ value	4.03905 (rank : 309)	NC score	0.234054 (rank : 106)
Query Neighborhood Hits	389	Target Neighborhood Hits	404	Shared Neighborhood Hits	153
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

WASF2_MOUSE
θ value	4.03905 (rank : 310)	NC score	0.072542 (rank : 319)
Query Neighborhood Hits	389	Target Neighborhood Hits	315	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WIRE_HUMAN
θ value	4.03905 (rank : 311)	NC score	0.089589 (rank : 246)
Query Neighborhood Hits	389	Target Neighborhood Hits	329	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ATN1_HUMAN
θ value	5.27518 (rank : 312)	NC score	0.106446 (rank : 197)
Query Neighborhood Hits	389	Target Neighborhood Hits	676	Shared Neighborhood Hits	91
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CABIN_HUMAN
θ value	5.27518 (rank : 313)	NC score	0.064601 (rank : 375)
Query Neighborhood Hits	389	Target Neighborhood Hits	490	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

DREB_HUMAN
θ value	5.27518 (rank : 314)	NC score	0.030569 (rank : 565)
Query Neighborhood Hits	389	Target Neighborhood Hits	450	Shared Neighborhood Hits	43
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DTX1_MOUSE
θ value	5.27518 (rank : 315)	NC score	0.027288 (rank : 573)
Query Neighborhood Hits	389	Target Neighborhood Hits	99	Shared Neighborhood Hits	26
SwissProt Accessions	Q61010, Q3TER5, Q8C2H2, Q9ER09	Gene names	Dtx1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (mDTX1) (FXI-T1).

JIP1_HUMAN
θ value	5.27518 (rank : 316)	NC score	0.091700 (rank : 240)
Query Neighborhood Hits	389	Target Neighborhood Hits	271	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LAP4_HUMAN
θ value	5.27518 (rank : 317)	NC score	0.008614 (rank : 622)
Query Neighborhood Hits	389	Target Neighborhood Hits	608	Shared Neighborhood Hits	42
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LSP1_MOUSE
θ value	5.27518 (rank : 318)	NC score	0.019803 (rank : 597)
Query Neighborhood Hits	389	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65	Gene names	Lsp1, Pp52, S37, Wp34
Domain Architecture
Description	Lymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein) (Lymphocyte-specific antigen WP34) (S37 protein).

MBRL_MOUSE
θ value	5.27518 (rank : 319)	NC score	0.016835 (rank : 604)
Query Neighborhood Hits	389	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CIV2, Q68EE1, Q6KAN7, Q7TS84, Q8CIV1, Q99K29	Gene names	ORF61
Domain Architecture	No domain graphic available
Description	Membralin.

NCOA6_HUMAN
θ value	5.27518 (rank : 320)	NC score	0.102347 (rank : 205)
Query Neighborhood Hits	389	Target Neighborhood Hits	1202	Shared Neighborhood Hits	162
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PRGC2_MOUSE
θ value	5.27518 (rank : 321)	NC score	0.038957 (rank : 541)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

RGS3_MOUSE
θ value	5.27518 (rank : 322)	NC score	0.128327 (rank : 164)
Query Neighborhood Hits	389	Target Neighborhood Hits	1621	Shared Neighborhood Hits	188
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TM16H_HUMAN
θ value	5.27518 (rank : 323)	NC score	0.046245 (rank : 523)
Query Neighborhood Hits	389	Target Neighborhood Hits	139	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

TRI16_HUMAN
θ value	5.27518 (rank : 324)	NC score	0.003960 (rank : 630)
Query Neighborhood Hits	389	Target Neighborhood Hits	231	Shared Neighborhood Hits	5
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

ZN385_HUMAN
θ value	5.27518 (rank : 325)	NC score	0.055894 (rank : 458)
Query Neighborhood Hits	389	Target Neighborhood Hits	614	Shared Neighborhood Hits	93
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZNF8_HUMAN
θ value	5.27518 (rank : 326)	NC score	-0.007659 (rank : 638)
Query Neighborhood Hits	389	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P17098, Q6PI99	Gene names	ZNF8
Domain Architecture	No domain graphic available
Description	Zinc finger protein 8 (Zinc finger protein HF.18).

ARHG4_HUMAN
θ value	6.88961 (rank : 327)	NC score	0.215574 (rank : 115)
Query Neighborhood Hits	389	Target Neighborhood Hits	242	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ATF5_MOUSE
θ value	6.88961 (rank : 328)	NC score	0.018641 (rank : 600)
Query Neighborhood Hits	389	Target Neighborhood Hits	62	Shared Neighborhood Hits	8
SwissProt Accessions	O70191, Q58E51, Q99NH6	Gene names	Atf5, Atfx, Nap1
Domain Architecture	No domain graphic available
Description	Cyclic AMP-dependent transcription factor ATF-5 (Activating transcription factor 5-alpha/beta) (Transcription factor ATFx) (Transcription factor-like protein ODA-10) (BZIP protein ATF7) (NRIF3- associated protein) (NAP1).

BIN1_HUMAN
θ value	6.88961 (rank : 329)	NC score	0.108904 (rank : 190)
Query Neighborhood Hits	389	Target Neighborhood Hits	335	Shared Neighborhood Hits	95
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CCDC4_HUMAN
θ value	6.88961 (rank : 330)	NC score	0.030264 (rank : 568)
Query Neighborhood Hits	389	Target Neighborhood Hits	104	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

DOK2_HUMAN
θ value	6.88961 (rank : 331)	NC score	0.011308 (rank : 616)
Query Neighborhood Hits	389	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

DSCL1_HUMAN
θ value	6.88961 (rank : 332)	NC score	0.004318 (rank : 629)
Query Neighborhood Hits	389	Target Neighborhood Hits	589	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DTX1_HUMAN
θ value	6.88961 (rank : 333)	NC score	0.022936 (rank : 586)
Query Neighborhood Hits	389	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q86Y01, O60630, Q9BS04	Gene names	DTX1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (hDTX1).

EMIL1_HUMAN
θ value	6.88961 (rank : 334)	NC score	0.007927 (rank : 624)
Query Neighborhood Hits	389	Target Neighborhood Hits	239	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6C2, Q96G58, Q9UG76	Gene names	EMILIN1, EMI
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

EP400_MOUSE
θ value	6.88961 (rank : 335)	NC score	0.032068 (rank : 559)
Query Neighborhood Hits	389	Target Neighborhood Hits	592	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

EVL_HUMAN
θ value	6.88961 (rank : 336)	NC score	0.031275 (rank : 561)
Query Neighborhood Hits	389	Target Neighborhood Hits	260	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

FRK_HUMAN
θ value	6.88961 (rank : 337)	NC score	0.085410 (rank : 268)
Query Neighborhood Hits	389	Target Neighborhood Hits	1058	Shared Neighborhood Hits	159
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HSF4_HUMAN
θ value	6.88961 (rank : 338)	NC score	0.016115 (rank : 607)
Query Neighborhood Hits	389	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULV5, Q99472, Q9ULV6	Gene names	HSF4
Domain Architecture
Description	Heat shock factor protein 4 (HSF 4) (Heat shock transcription factor 4) (HSTF 4) (hHSF4).

ITK_HUMAN
θ value	6.88961 (rank : 339)	NC score	0.065566 (rank : 366)
Query Neighborhood Hits	389	Target Neighborhood Hits	1016	Shared Neighborhood Hits	123
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

JHD3D_HUMAN
θ value	6.88961 (rank : 340)	NC score	0.010399 (rank : 618)
Query Neighborhood Hits	389	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	Q6B0I6, Q9NT41, Q9NW76	Gene names	JMJD2D, JHDM3D
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 3D (EC 1.14.11.-) (Jumonji domain-containing protein 2D).

K0174_MOUSE
θ value	6.88961 (rank : 341)	NC score	0.018306 (rank : 602)
Query Neighborhood Hits	389	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CX00, Q80U68	Gene names	Kiaa0174
Domain Architecture	No domain graphic available
Description	Protein KIAA0174.

LDB3_HUMAN
θ value	6.88961 (rank : 342)	NC score	0.041170 (rank : 532)
Query Neighborhood Hits	389	Target Neighborhood Hits	497	Shared Neighborhood Hits	56
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LRP5_MOUSE
θ value	6.88961 (rank : 343)	NC score	0.001549 (rank : 632)
Query Neighborhood Hits	389	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

MILK1_MOUSE
θ value	6.88961 (rank : 344)	NC score	0.068603 (rank : 340)
Query Neighborhood Hits	389	Target Neighborhood Hits	788	Shared Neighborhood Hits	129
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK2_HUMAN
θ value	6.88961 (rank : 345)	NC score	0.041021 (rank : 534)
Query Neighborhood Hits	389	Target Neighborhood Hits	457	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

NR1H2_MOUSE
θ value	6.88961 (rank : 346)	NC score	0.000150 (rank : 634)
Query Neighborhood Hits	389	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

PCLO_MOUSE
θ value	6.88961 (rank : 347)	NC score	0.102229 (rank : 206)
Query Neighborhood Hits	389	Target Neighborhood Hits	2275	Shared Neighborhood Hits	196
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PELP1_MOUSE
θ value	6.88961 (rank : 348)	NC score	0.085727 (rank : 263)
Query Neighborhood Hits	389	Target Neighborhood Hits	709	Shared Neighborhood Hits	105
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

RGS3_HUMAN
θ value	6.88961 (rank : 349)	NC score	0.095899 (rank : 228)
Query Neighborhood Hits	389	Target Neighborhood Hits	1375	Shared Neighborhood Hits	172
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SETB1_MOUSE
θ value	6.88961 (rank : 350)	NC score	0.022847 (rank : 587)
Query Neighborhood Hits	389	Target Neighborhood Hits	150	Shared Neighborhood Hits	25
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SSH1_HUMAN
θ value	6.88961 (rank : 351)	NC score	0.015547 (rank : 609)
Query Neighborhood Hits	389	Target Neighborhood Hits	164	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

STAM1_HUMAN
θ value	6.88961 (rank : 352)	NC score	0.308721 (rank : 69)
Query Neighborhood Hits	389	Target Neighborhood Hits	271	Shared Neighborhood Hits	154
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	6.88961 (rank : 353)	NC score	0.308814 (rank : 68)
Query Neighborhood Hits	389	Target Neighborhood Hits	273	Shared Neighborhood Hits	157
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

WASIP_MOUSE
θ value	6.88961 (rank : 354)	NC score	0.112685 (rank : 181)
Query Neighborhood Hits	389	Target Neighborhood Hits	392	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WIRE_MOUSE
θ value	6.88961 (rank : 355)	NC score	0.085546 (rank : 265)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

ZC3H5_HUMAN
θ value	6.88961 (rank : 356)	NC score	0.010648 (rank : 617)
Query Neighborhood Hits	389	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZN703_HUMAN
θ value	6.88961 (rank : 357)	NC score	0.025239 (rank : 579)
Query Neighborhood Hits	389	Target Neighborhood Hits	154	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H7S9, Q5XG76	Gene names	ZNF703
Domain Architecture	No domain graphic available
Description	Zinc finger protein 703.

ZO1_HUMAN
θ value	6.88961 (rank : 358)	NC score	0.039986 (rank : 536)
Query Neighborhood Hits	389	Target Neighborhood Hits	474	Shared Neighborhood Hits	60
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ACD_HUMAN
θ value	8.99809 (rank : 359)	NC score	0.024465 (rank : 581)
Query Neighborhood Hits	389	Target Neighborhood Hits	143	Shared Neighborhood Hits	27
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

ARHG6_HUMAN
θ value	8.99809 (rank : 360)	NC score	0.277846 (rank : 86)
Query Neighborhood Hits	389	Target Neighborhood Hits	376	Shared Neighborhood Hits	148
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

BAG3_MOUSE
θ value	8.99809 (rank : 361)	NC score	0.076778 (rank : 296)
Query Neighborhood Hits	389	Target Neighborhood Hits	513	Shared Neighborhood Hits	98
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CBX2_HUMAN
θ value	8.99809 (rank : 362)	NC score	0.024211 (rank : 583)
Query Neighborhood Hits	389	Target Neighborhood Hits	264	Shared Neighborhood Hits	26
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

DPYL3_HUMAN
θ value	8.99809 (rank : 363)	NC score	0.003196 (rank : 631)
Query Neighborhood Hits	389	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q14195, Q93012	Gene names	DPYSL3, CRMP4, DRP3, ULIP
Domain Architecture
Description	Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein) (ULIP protein) (Collapsin response mediator protein 4) (CRMP-4).

DUS2L_MOUSE
θ value	8.99809 (rank : 364)	NC score	0.008310 (rank : 623)
Query Neighborhood Hits	389	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D7B1, Q6PDX2	Gene names	Dus2l
Domain Architecture	No domain graphic available
Description	tRNA-dihydrouridine synthase 2-like (EC 1.-.-.-).

FGR_HUMAN
θ value	8.99809 (rank : 365)	NC score	0.099704 (rank : 218)
Query Neighborhood Hits	389	Target Neighborhood Hits	1067	Shared Neighborhood Hits	157
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	8.99809 (rank : 366)	NC score	0.096652 (rank : 227)
Query Neighborhood Hits	389	Target Neighborhood Hits	1069	Shared Neighborhood Hits	158
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GNAS1_HUMAN
θ value	8.99809 (rank : 367)	NC score	0.025826 (rank : 577)
Query Neighborhood Hits	389	Target Neighborhood Hits	278	Shared Neighborhood Hits	47
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

GNAS1_MOUSE
θ value	8.99809 (rank : 368)	NC score	0.048395 (rank : 518)
Query Neighborhood Hits	389	Target Neighborhood Hits	651	Shared Neighborhood Hits	102
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

GRB10_MOUSE
θ value	8.99809 (rank : 369)	NC score	0.060544 (rank : 411)
Query Neighborhood Hits	389	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

IDUA_MOUSE
θ value	8.99809 (rank : 370)	NC score	0.010178 (rank : 619)
Query Neighborhood Hits	389	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P48441	Gene names	Idua
Domain Architecture
Description	Alpha-L-iduronidase precursor (EC 3.2.1.76).

IGHG3_HUMAN
θ value	8.99809 (rank : 371)	NC score	0.000361 (rank : 633)
Query Neighborhood Hits	389	Target Neighborhood Hits	234	Shared Neighborhood Hits	5
SwissProt Accessions	P01860	Gene names	IGHG3
Domain Architecture
Description	Ig gamma-3 chain C region (Heavy chain disease protein) (HDC).

JAG2_MOUSE
θ value	8.99809 (rank : 372)	NC score	-0.002181 (rank : 635)
Query Neighborhood Hits	389	Target Neighborhood Hits	504	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

JIP3_HUMAN
θ value	8.99809 (rank : 373)	NC score	0.033547 (rank : 555)
Query Neighborhood Hits	389	Target Neighborhood Hits	1039	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

K1802_MOUSE
θ value	8.99809 (rank : 374)	NC score	0.085528 (rank : 266)
Query Neighborhood Hits	389	Target Neighborhood Hits	1596	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LITAF_MOUSE
θ value	8.99809 (rank : 375)	NC score	0.013736 (rank : 612)
Query Neighborhood Hits	389	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLJ0, Q9EQI0	Gene names	Litaf, N4wbp3, Tbx1
Domain Architecture	No domain graphic available
Description	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) (Estrogen-enhanced transcript protein) (mEET).

MATK_MOUSE
θ value	8.99809 (rank : 376)	NC score	0.053912 (rank : 481)
Query Neighborhood Hits	389	Target Neighborhood Hits	952	Shared Neighborhood Hits	82
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PIWL2_HUMAN
θ value	8.99809 (rank : 377)	NC score	0.005214 (rank : 627)
Query Neighborhood Hits	389	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TC59, Q96SW6, Q9NW28	Gene names	PIWIL2, HILI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 2.

PRR12_HUMAN
θ value	8.99809 (rank : 378)	NC score	0.108271 (rank : 192)
Query Neighborhood Hits	389	Target Neighborhood Hits	460	Shared Neighborhood Hits	82
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RANB9_HUMAN
θ value	8.99809 (rank : 379)	NC score	0.030549 (rank : 566)
Query Neighborhood Hits	389	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

REC8L_HUMAN
θ value	8.99809 (rank : 380)	NC score	0.012144 (rank : 615)
Query Neighborhood Hits	389	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	O95072, Q8WUV8, Q9BTF2, Q9NVQ9	Gene names	REC8L1, REC8
Domain Architecture
Description	Meiotic recombination protein REC8-like 1 (Cohesin Rec8p).

SMOO_HUMAN
θ value	8.99809 (rank : 381)	NC score	0.045697 (rank : 526)
Query Neighborhood Hits	389	Target Neighborhood Hits	391	Shared Neighborhood Hits	58
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SNPC2_MOUSE
θ value	8.99809 (rank : 382)	NC score	0.023447 (rank : 585)
Query Neighborhood Hits	389	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	Q91XA5, Q3UK17, Q8CBS9	Gene names	Snapc2
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2).

SOX17_MOUSE
θ value	8.99809 (rank : 383)	NC score	0.026642 (rank : 576)
Query Neighborhood Hits	389	Target Neighborhood Hits	223	Shared Neighborhood Hits	41
SwissProt Accessions	Q61473, Q61472, Q62248	Gene names	Sox17, Sox-17
Domain Architecture
Description	Transcription factor SOX-17.

SPEG_MOUSE
θ value	8.99809 (rank : 384)	NC score	0.041048 (rank : 533)
Query Neighborhood Hits	389	Target Neighborhood Hits	1959	Shared Neighborhood Hits	159
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SRRM2_MOUSE
θ value	8.99809 (rank : 385)	NC score	0.086537 (rank : 261)
Query Neighborhood Hits	389	Target Neighborhood Hits	1470	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TCGAP_HUMAN
θ value	8.99809 (rank : 386)	NC score	0.184311 (rank : 127)
Query Neighborhood Hits	389	Target Neighborhood Hits	872	Shared Neighborhood Hits	215
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	8.99809 (rank : 387)	NC score	0.157451 (rank : 141)
Query Neighborhood Hits	389	Target Neighborhood Hits	409	Shared Neighborhood Hits	149
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

WBS14_HUMAN
θ value	8.99809 (rank : 388)	NC score	0.037889 (rank : 544)
Query Neighborhood Hits	389	Target Neighborhood Hits	273	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

WNK4_MOUSE
θ value	8.99809 (rank : 389)	NC score	0.031099 (rank : 562)
Query Neighborhood Hits	389	Target Neighborhood Hits	961	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

3BP1_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.061646 (rank : 396)
Query Neighborhood Hits	389	Target Neighborhood Hits	376	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABL2_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.064861 (rank : 371)
Query Neighborhood Hits	389	Target Neighborhood Hits	1045	Shared Neighborhood Hits	121
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.050751 (rank : 508)
Query Neighborhood Hits	389	Target Neighborhood Hits	166	Shared Neighborhood Hits	34
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ALEX_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.055580 (rank : 465)
Query Neighborhood Hits	389	Target Neighborhood Hits	361	Shared Neighborhood Hits	67
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

AMPH_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.108934 (rank : 189)
Query Neighborhood Hits	389	Target Neighborhood Hits	455	Shared Neighborhood Hits	115
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.093706 (rank : 236)
Query Neighborhood Hits	389	Target Neighborhood Hits	291	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.154179 (rank : 143)
Query Neighborhood Hits	389	Target Neighborhood Hits	175	Shared Neighborhood Hits	123
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.148710 (rank : 149)
Query Neighborhood Hits	389	Target Neighborhood Hits	175	Shared Neighborhood Hits	119
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.057275 (rank : 444)
Query Neighborhood Hits	389	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.059255 (rank : 422)
Query Neighborhood Hits	389	Target Neighborhood Hits	176	Shared Neighborhood Hits	26
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.060849 (rank : 409)
Query Neighborhood Hits	389	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.050893 (rank : 507)
Query Neighborhood Hits	389	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG3_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.074047 (rank : 307)
Query Neighborhood Hits	389	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.073858 (rank : 309)
Query Neighborhood Hits	389	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.154302 (rank : 142)
Query Neighborhood Hits	389	Target Neighborhood Hits	185	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.113049 (rank : 177)
Query Neighborhood Hits	389	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.067853 (rank : 347)
Query Neighborhood Hits	389	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.065944 (rank : 364)
Query Neighborhood Hits	389	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.062128 (rank : 392)
Query Neighborhood Hits	389	Target Neighborhood Hits	187	Shared Neighborhood Hits	25
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.066261 (rank : 358)
Query Neighborhood Hits	389	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.061842 (rank : 395)
Query Neighborhood Hits	389	Target Neighborhood Hits	375	Shared Neighborhood Hits	45
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.060586 (rank : 410)
Query Neighborhood Hits	389	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.060027 (rank : 414)
Query Neighborhood Hits	389	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.073322 (rank : 314)
Query Neighborhood Hits	389	Target Neighborhood Hits	214	Shared Neighborhood Hits	54
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.078140 (rank : 292)
Query Neighborhood Hits	389	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.090767 (rank : 244)
Query Neighborhood Hits	389	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARI1A_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.071570 (rank : 326)
Query Neighborhood Hits	389	Target Neighborhood Hits	787	Shared Neighborhood Hits	101
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ARI1B_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.051129 (rank : 506)
Query Neighborhood Hits	389	Target Neighborhood Hits	567	Shared Neighborhood Hits	75
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

ATX2L_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.054422 (rank : 474)
Query Neighborhood Hits	389	Target Neighborhood Hits	443	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

ATX2L_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.051432 (rank : 503)
Query Neighborhood Hits	389	Target Neighborhood Hits	401	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

ATX2_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.053521 (rank : 482)
Query Neighborhood Hits	389	Target Neighborhood Hits	445	Shared Neighborhood Hits	78
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

BAIP2_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.063244 (rank : 384)
Query Neighborhood Hits	389	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.064889 (rank : 370)
Query Neighborhood Hits	389	Target Neighborhood Hits	185	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BASP_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.058570 (rank : 430)
Query Neighborhood Hits	389	Target Neighborhood Hits	260	Shared Neighborhood Hits	29
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BAT3_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.055698 (rank : 462)
Query Neighborhood Hits	389	Target Neighborhood Hits	490	Shared Neighborhood Hits	85
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAT3_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.054581 (rank : 472)
Query Neighborhood Hits	389	Target Neighborhood Hits	518	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

BCL9_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.083988 (rank : 274)
Query Neighborhood Hits	389	Target Neighborhood Hits	770	Shared Neighborhood Hits	124
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BCR_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.059031 (rank : 425)
Query Neighborhood Hits	389	Target Neighborhood Hits	204	Shared Neighborhood Hits	42
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.071025 (rank : 330)
Query Neighborhood Hits	389	Target Neighborhood Hits	156	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.064736 (rank : 374)
Query Neighborhood Hits	389	Target Neighborhood Hits	197	Shared Neighborhood Hits	58
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.096892 (rank : 226)
Query Neighborhood Hits	389	Target Neighborhood Hits	283	Shared Neighborhood Hits	93
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.077338 (rank : 295)
Query Neighborhood Hits	389	Target Neighborhood Hits	994	Shared Neighborhood Hits	131
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.074313 (rank : 305)
Query Neighborhood Hits	389	Target Neighborhood Hits	992	Shared Neighborhood Hits	121
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.059263 (rank : 421)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.083657 (rank : 278)
Query Neighborhood Hits	389	Target Neighborhood Hits	296	Shared Neighborhood Hits	81
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BSN_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.082201 (rank : 280)
Query Neighborhood Hits	389	Target Neighborhood Hits	1537	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BTK_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.087654 (rank : 253)
Query Neighborhood Hits	389	Target Neighborhood Hits	1017	Shared Neighborhood Hits	150
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CBP_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.098648 (rank : 222)
Query Neighborhood Hits	389	Target Neighborhood Hits	1051	Shared Neighborhood Hits	139
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CCNK_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.063025 (rank : 385)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	53
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

CD2_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.063644 (rank : 379)
Query Neighborhood Hits	389	Target Neighborhood Hits	504	Shared Neighborhood Hits	87
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CDN1C_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.056046 (rank : 456)
Query Neighborhood Hits	389	Target Neighborhood Hits	168	Shared Neighborhood Hits	43
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CECR2_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.050073 (rank : 515)
Query Neighborhood Hits	389	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CEL_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.083706 (rank : 277)
Query Neighborhood Hits	389	Target Neighborhood Hits	896	Shared Neighborhood Hits	140
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CIC_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.082398 (rank : 279)
Query Neighborhood Hits	389	Target Neighborhood Hits	992	Shared Neighborhood Hits	145
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CIC_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.059150 (rank : 423)
Query Neighborhood Hits	389	Target Neighborhood Hits	742	Shared Neighborhood Hits	105
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CIP4_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.116702 (rank : 174)
Query Neighborhood Hits	389	Target Neighborhood Hits	374	Shared Neighborhood Hits	75
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CJ078_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.052188 (rank : 497)
Query Neighborhood Hits	389	Target Neighborhood Hits	559	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CK024_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.087085 (rank : 256)
Query Neighborhood Hits	389	Target Neighborhood Hits	408	Shared Neighborhood Hits	84
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CO039_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.057524 (rank : 437)
Query Neighborhood Hits	389	Target Neighborhood Hits	264	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CO039_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.074187 (rank : 306)
Query Neighborhood Hits	389	Target Neighborhood Hits	445	Shared Neighborhood Hits	99
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CPSF6_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.066063 (rank : 359)
Query Neighborhood Hits	389	Target Neighborhood Hits	359	Shared Neighborhood Hits	53
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.066761 (rank : 354)
Query Neighborhood Hits	389	Target Neighborhood Hits	356	Shared Neighborhood Hits	54
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CRKL_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.302937 (rank : 72)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	156
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CSKI1_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.063786 (rank : 378)
Query Neighborhood Hits	389	Target Neighborhood Hits	1031	Shared Neighborhood Hits	151
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI2_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.053097 (rank : 487)
Query Neighborhood Hits	389	Target Neighborhood Hits	812	Shared Neighborhood Hits	111
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSK_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.071958 (rank : 322)
Query Neighborhood Hits	389	Target Neighborhood Hits	1009	Shared Neighborhood Hits	129
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.072144 (rank : 321)
Query Neighborhood Hits	389	Target Neighborhood Hits	1009	Shared Neighborhood Hits	129
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPP1_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.071935 (rank : 323)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.071467 (rank : 328)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.255450 (rank : 96)
Query Neighborhood Hits	389	Target Neighborhood Hits	244	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.253308 (rank : 99)
Query Neighborhood Hits	389	Target Neighborhood Hits	306	Shared Neighborhood Hits	135
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.143088 (rank : 155)
Query Neighborhood Hits	389	Target Neighborhood Hits	592	Shared Neighborhood Hits	151
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.138046 (rank : 159)
Query Neighborhood Hits	389	Target Neighborhood Hits	599	Shared Neighborhood Hits	145
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.138397 (rank : 158)
Query Neighborhood Hits	389	Target Neighborhood Hits	625	Shared Neighborhood Hits	144
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKK_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.053517 (rank : 483)
Query Neighborhood Hits	389	Target Neighborhood Hits	378	Shared Neighborhood Hits	55
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DOCK1_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.086749 (rank : 260)
Query Neighborhood Hits	389	Target Neighborhood Hits	191	Shared Neighborhood Hits	101
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ECT2_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.061256 (rank : 403)
Query Neighborhood Hits	389	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.064193 (rank : 377)
Query Neighborhood Hits	389	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.053326 (rank : 485)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	83
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.051648 (rank : 502)
Query Neighborhood Hits	389	Target Neighborhood Hits	221	Shared Neighborhood Hits	78
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FA47A_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.066022 (rank : 361)
Query Neighborhood Hits	389	Target Neighborhood Hits	451	Shared Neighborhood Hits	86
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FA47B_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.098847 (rank : 221)
Query Neighborhood Hits	389	Target Neighborhood Hits	431	Shared Neighborhood Hits	99
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FGD2_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.058355 (rank : 432)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.057036 (rank : 448)
Query Neighborhood Hits	389	Target Neighborhood Hits	163	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.061285 (rank : 402)
Query Neighborhood Hits	389	Target Neighborhood Hits	249	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.063519 (rank : 383)
Query Neighborhood Hits	389	Target Neighborhood Hits	257	Shared Neighborhood Hits	28
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.057810 (rank : 433)
Query Neighborhood Hits	389	Target Neighborhood Hits	219	Shared Neighborhood Hits	24
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.057461 (rank : 440)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.051971 (rank : 499)
Query Neighborhood Hits	389	Target Neighborhood Hits	282	Shared Neighborhood Hits	35
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FMN1A_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.060921 (rank : 408)
Query Neighborhood Hits	389	Target Neighborhood Hits	423	Shared Neighborhood Hits	64
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.063008 (rank : 386)
Query Neighborhood Hits	389	Target Neighborhood Hits	447	Shared Neighborhood Hits	68
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

FMN2_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.057628 (rank : 436)
Query Neighborhood Hits	389	Target Neighborhood Hits	349	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

FMNL_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.055726 (rank : 461)
Query Neighborhood Hits	389	Target Neighborhood Hits	428	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.154023 (rank : 144)
Query Neighborhood Hits	389	Target Neighborhood Hits	432	Shared Neighborhood Hits	138
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYB_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.051814 (rank : 501)
Query Neighborhood Hits	389	Target Neighborhood Hits	379	Shared Neighborhood Hits	68
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GGN_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.094220 (rank : 235)
Query Neighborhood Hits	389	Target Neighborhood Hits	311	Shared Neighborhood Hits	60
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GPS2_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.056888 (rank : 449)
Query Neighborhood Hits	389	Target Neighborhood Hits	459	Shared Neighborhood Hits	52
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

GRB10_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.056351 (rank : 452)
Query Neighborhood Hits	389	Target Neighborhood Hits	147	Shared Neighborhood Hits	45
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB14_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.068009 (rank : 346)
Query Neighborhood Hits	389	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.069417 (rank : 338)
Query Neighborhood Hits	389	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.060251 (rank : 412)
Query Neighborhood Hits	389	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.064749 (rank : 373)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.053016 (rank : 488)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.054569 (rank : 473)
Query Neighborhood Hits	389	Target Neighborhood Hits	159	Shared Neighborhood Hits	42
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IF4G1_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.053980 (rank : 480)
Query Neighborhood Hits	389	Target Neighborhood Hits	534	Shared Neighborhood Hits	96
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

ITK_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.057715 (rank : 435)
Query Neighborhood Hits	389	Target Neighborhood Hits	985	Shared Neighborhood Hits	110
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JIP2_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.080085 (rank : 285)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	83
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.066287 (rank : 357)
Query Neighborhood Hits	389	Target Neighborhood Hits	144	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K0310_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.057436 (rank : 441)
Query Neighborhood Hits	389	Target Neighborhood Hits	420	Shared Neighborhood Hits	81
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

K1543_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.061031 (rank : 407)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1543_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.052202 (rank : 496)
Query Neighborhood Hits	389	Target Neighborhood Hits	497	Shared Neighborhood Hits	91
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1802_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.066015 (rank : 362)
Query Neighborhood Hits	389	Target Neighborhood Hits	1378	Shared Neighborhood Hits	140
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LBC_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.055312 (rank : 469)
Query Neighborhood Hits	389	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.068151 (rank : 344)
Query Neighborhood Hits	389	Target Neighborhood Hits	987	Shared Neighborhood Hits	114
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.067323 (rank : 351)
Query Neighborhood Hits	389	Target Neighborhood Hits	981	Shared Neighborhood Hits	112
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.111780 (rank : 184)
Query Neighborhood Hits	389	Target Neighborhood Hits	531	Shared Neighborhood Hits	128
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.065981 (rank : 363)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.059289 (rank : 420)
Query Neighborhood Hits	389	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LPP_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.067257 (rank : 352)
Query Neighborhood Hits	389	Target Neighborhood Hits	775	Shared Neighborhood Hits	132
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MAVS_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.059893 (rank : 415)
Query Neighborhood Hits	389	Target Neighborhood Hits	271	Shared Neighborhood Hits	47
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MBD6_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.101712 (rank : 210)
Query Neighborhood Hits	389	Target Neighborhood Hits	349	Shared Neighborhood Hits	62
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MCF2L_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.092050 (rank : 239)
Query Neighborhood Hits	389	Target Neighborhood Hits	255	Shared Neighborhood Hits	49
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.061196 (rank : 405)
Query Neighborhood Hits	389	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MDC1_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.103516 (rank : 202)
Query Neighborhood Hits	389	Target Neighborhood Hits	1446	Shared Neighborhood Hits	144
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.086849 (rank : 259)
Query Neighborhood Hits	389	Target Neighborhood Hits	998	Shared Neighborhood Hits	126
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MINT_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.061341 (rank : 400)
Query Neighborhood Hits	389	Target Neighborhood Hits	1514	Shared Neighborhood Hits	146
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MISS_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.100486 (rank : 214)
Query Neighborhood Hits	389	Target Neighborhood Hits	444	Shared Neighborhood Hits	100
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MKL1_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.064517 (rank : 376)
Query Neighborhood Hits	389	Target Neighborhood Hits	667	Shared Neighborhood Hits	116
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MLL3_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.080060 (rank : 287)
Query Neighborhood Hits	389	Target Neighborhood Hits	1399	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MNT_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.063587 (rank : 381)
Query Neighborhood Hits	389	Target Neighborhood Hits	496	Shared Neighborhood Hits	83
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.053483 (rank : 484)
Query Neighborhood Hits	389	Target Neighborhood Hits	432	Shared Neighborhood Hits	62
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MTSS1_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.061391 (rank : 399)
Query Neighborhood Hits	389	Target Neighborhood Hits	592	Shared Neighborhood Hits	95
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MUC1_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.056229 (rank : 454)
Query Neighborhood Hits	389	Target Neighborhood Hits	388	Shared Neighborhood Hits	35
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MUC2_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.057155 (rank : 446)
Query Neighborhood Hits	389	Target Neighborhood Hits	906	Shared Neighborhood Hits	77
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MUCDL_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.069579 (rank : 336)
Query Neighborhood Hits	389	Target Neighborhood Hits	777	Shared Neighborhood Hits	116
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NCOA6_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.088979 (rank : 249)
Query Neighborhood Hits	389	Target Neighborhood Hits	1076	Shared Neighborhood Hits	138
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NGEF_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.107560 (rank : 193)
Query Neighborhood Hits	389	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.112885 (rank : 179)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NUMBL_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.066489 (rank : 356)
Query Neighborhood Hits	389	Target Neighborhood Hits	394	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

P55G_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.071471 (rank : 327)
Query Neighborhood Hits	389	Target Neighborhood Hits	451	Shared Neighborhood Hits	53
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.070616 (rank : 333)
Query Neighborhood Hits	389	Target Neighborhood Hits	401	Shared Neighborhood Hits	51
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PCQAP_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.055916 (rank : 457)
Query Neighborhood Hits	389	Target Neighborhood Hits	506	Shared Neighborhood Hits	60
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PELP1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.052230 (rank : 495)
Query Neighborhood Hits	389	Target Neighborhood Hits	596	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PI5PA_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.084764 (rank : 271)
Query Neighborhood Hits	389	Target Neighborhood Hits	749	Shared Neighborhood Hits	134
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PI5PA_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.051288 (rank : 505)
Query Neighborhood Hits	389	Target Neighborhood Hits	331	Shared Neighborhood Hits	74
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PKHG1_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.076426 (rank : 297)
Query Neighborhood Hits	389	Target Neighborhood Hits	174	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG1_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.180824 (rank : 132)
Query Neighborhood Hits	389	Target Neighborhood Hits	293	Shared Neighborhood Hits	133
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.189849 (rank : 122)
Query Neighborhood Hits	389	Target Neighborhood Hits	314	Shared Neighborhood Hits	137
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.183400 (rank : 129)
Query Neighborhood Hits	389	Target Neighborhood Hits	280	Shared Neighborhood Hits	134
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PO121_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.052922 (rank : 490)
Query Neighborhood Hits	389	Target Neighborhood Hits	345	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

PPIP2_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.094821 (rank : 232)
Query Neighborhood Hits	389	Target Neighborhood Hits	254	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.089477 (rank : 247)
Query Neighborhood Hits	389	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PRB3_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.080077 (rank : 286)
Query Neighborhood Hits	389	Target Neighborhood Hits	318	Shared Neighborhood Hits	51
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.094914 (rank : 231)
Query Neighborhood Hits	389	Target Neighborhood Hits	330	Shared Neighborhood Hits	56
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PREX1_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.074889 (rank : 300)
Query Neighborhood Hits	389	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRG4_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.063529 (rank : 382)
Query Neighborhood Hits	389	Target Neighborhood Hits	764	Shared Neighborhood Hits	75
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.107292 (rank : 195)
Query Neighborhood Hits	389	Target Neighborhood Hits	385	Shared Neighborhood Hits	62
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.119384 (rank : 168)
Query Neighborhood Hits	389	Target Neighborhood Hits	347	Shared Neighborhood Hits	64
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRPC_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.054647 (rank : 471)
Query Neighborhood Hits	389	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

PSL1_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.073414 (rank : 312)
Query Neighborhood Hits	389	Target Neighborhood Hits	650	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PTK6_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.073292 (rank : 315)
Query Neighborhood Hits	389	Target Neighborhood Hits	1020	Shared Neighborhood Hits	143
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.071899 (rank : 324)
Query Neighborhood Hits	389	Target Neighborhood Hits	1026	Shared Neighborhood Hits	139
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

R3HD2_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.050136 (rank : 514)
Query Neighborhood Hits	389	Target Neighborhood Hits	397	Shared Neighborhood Hits	65
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RASA1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.077344 (rank : 294)
Query Neighborhood Hits	389	Target Neighborhood Hits	258	Shared Neighborhood Hits	61
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RERE_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.087631 (rank : 254)
Query Neighborhood Hits	389	Target Neighborhood Hits	785	Shared Neighborhood Hits	87
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.057246 (rank : 445)
Query Neighborhood Hits	389	Target Neighborhood Hits	641	Shared Neighborhood Hits	50
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RTP3_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.050236 (rank : 513)
Query Neighborhood Hits	389	Target Neighborhood Hits	374	Shared Neighborhood Hits	66
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

S23IP_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.055149 (rank : 470)
Query Neighborhood Hits	389	Target Neighborhood Hits	363	Shared Neighborhood Hits	69
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

SASH1_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.057522 (rank : 438)
Query Neighborhood Hits	389	Target Neighborhood Hits	292	Shared Neighborhood Hits	85
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.055574 (rank : 466)
Query Neighborhood Hits	389	Target Neighborhood Hits	263	Shared Neighborhood Hits	72
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SC24A_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.059859 (rank : 416)
Query Neighborhood Hits	389	Target Neighborhood Hits	394	Shared Neighborhood Hits	91
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SC24C_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.068040 (rank : 345)
Query Neighborhood Hits	389	Target Neighborhood Hits	662	Shared Neighborhood Hits	111
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SELPL_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.083960 (rank : 276)
Query Neighborhood Hits	389	Target Neighborhood Hits	588	Shared Neighborhood Hits	93
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SELV_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.061436 (rank : 397)
Query Neighborhood Hits	389	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

SEPT9_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.050254 (rank : 512)
Query Neighborhood Hits	389	Target Neighborhood Hits	706	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SET1A_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.057355 (rank : 442)
Query Neighborhood Hits	389	Target Neighborhood Hits	690	Shared Neighborhood Hits	72
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SF3A2_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.100278 (rank : 216)
Query Neighborhood Hits	389	Target Neighborhood Hits	263	Shared Neighborhood Hits	44
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SF3A2_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.098421 (rank : 223)
Query Neighborhood Hits	389	Target Neighborhood Hits	247	Shared Neighborhood Hits	44
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SFPQ_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.074914 (rank : 299)
Query Neighborhood Hits	389	Target Neighborhood Hits	986	Shared Neighborhood Hits	88
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SH21A_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.051394 (rank : 504)
Query Neighborhood Hits	389	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.051865 (rank : 500)
Query Neighborhood Hits	389	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.073370 (rank : 313)
Query Neighborhood Hits	389	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.073829 (rank : 310)
Query Neighborhood Hits	389	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.053252 (rank : 486)
Query Neighborhood Hits	389	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SHAN1_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.127954 (rank : 165)
Query Neighborhood Hits	389	Target Neighborhood Hits	1041	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHB_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.061319 (rank : 401)
Query Neighborhood Hits	389	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.062794 (rank : 388)
Query Neighborhood Hits	389	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.061416 (rank : 398)
Query Neighborhood Hits	389	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.057797 (rank : 434)
Query Neighborhood Hits	389	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.055667 (rank : 463)
Query Neighborhood Hits	389	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.056140 (rank : 455)
Query Neighborhood Hits	389	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.056628 (rank : 450)
Query Neighborhood Hits	389	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.061062 (rank : 406)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.065902 (rank : 365)
Query Neighborhood Hits	389	Target Neighborhood Hits	204	Shared Neighborhood Hits	55
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.059658 (rank : 417)
Query Neighborhood Hits	389	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.061207 (rank : 404)
Query Neighborhood Hits	389	Target Neighborhood Hits	164	Shared Neighborhood Hits	46
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.062841 (rank : 387)
Query Neighborhood Hits	389	Target Neighborhood Hits	169	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.144415 (rank : 154)
Query Neighborhood Hits	389	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.150088 (rank : 147)
Query Neighborhood Hits	389	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.117893 (rank : 173)
Query Neighborhood Hits	389	Target Neighborhood Hits	86	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.119273 (rank : 170)
Query Neighborhood Hits	389	Target Neighborhood Hits	88	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.086880 (rank : 258)
Query Neighborhood Hits	389	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.084959 (rank : 269)
Query Neighborhood Hits	389	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.102066 (rank : 208)
Query Neighborhood Hits	389	Target Neighborhood Hits	139	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.099338 (rank : 219)
Query Neighborhood Hits	389	Target Neighborhood Hits	136	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.066612 (rank : 355)
Query Neighborhood Hits	389	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.078509 (rank : 289)
Query Neighborhood Hits	389	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNPC4_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.062098 (rank : 393)
Query Neighborhood Hits	389	Target Neighborhood Hits	589	Shared Neighborhood Hits	105
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SON_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.084929 (rank : 270)
Query Neighborhood Hits	389	Target Neighborhood Hits	957	Shared Neighborhood Hits	117
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SPN90_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.113287 (rank : 176)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPR1A_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.052732 (rank : 492)
Query Neighborhood Hits	389	Target Neighborhood Hits	343	Shared Neighborhood Hits	74
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SPR1B_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.070930 (rank : 331)
Query Neighborhood Hits	389	Target Neighborhood Hits	395	Shared Neighborhood Hits	85
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SPT5H_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.072605 (rank : 318)
Query Neighborhood Hits	389	Target Neighborhood Hits	436	Shared Neighborhood Hits	81
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.072341 (rank : 320)
Query Neighborhood Hits	389	Target Neighborhood Hits	437	Shared Neighborhood Hits	80
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SRGP1_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.159731 (rank : 139)
Query Neighborhood Hits	389	Target Neighborhood Hits	390	Shared Neighborhood Hits	129
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRRM1_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.074632 (rank : 301)
Query Neighborhood Hits	389	Target Neighborhood Hits	690	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.094604 (rank : 234)
Query Neighborhood Hits	389	Target Neighborhood Hits	966	Shared Neighborhood Hits	131
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.068509 (rank : 341)
Query Neighborhood Hits	389	Target Neighborhood Hits	1296	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SSBP4_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.064820 (rank : 372)
Query Neighborhood Hits	389	Target Neighborhood Hits	753	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC3_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.216067 (rank : 114)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	125
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.217225 (rank : 112)
Query Neighborhood Hits	389	Target Neighborhood Hits	232	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.291663 (rank : 76)
Query Neighborhood Hits	389	Target Neighborhood Hits	276	Shared Neighborhood Hits	141
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.277504 (rank : 87)
Query Neighborhood Hits	389	Target Neighborhood Hits	268	Shared Neighborhood Hits	138
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STS1_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.088773 (rank : 250)
Query Neighborhood Hits	389	Target Neighborhood Hits	106	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.088239 (rank : 251)
Query Neighborhood Hits	389	Target Neighborhood Hits	104	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.109373 (rank : 188)
Query Neighborhood Hits	389	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SYN1_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.069454 (rank : 337)
Query Neighborhood Hits	389	Target Neighborhood Hits	419	Shared Neighborhood Hits	72
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

SYN1_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.059530 (rank : 418)
Query Neighborhood Hits	389	Target Neighborhood Hits	363	Shared Neighborhood Hits	60
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

SYP2L_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.057344 (rank : 443)
Query Neighborhood Hits	389	Target Neighborhood Hits	289	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

T22D2_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.055346 (rank : 467)
Query Neighborhood Hits	389	Target Neighborhood Hits	250	Shared Neighborhood Hits	45
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TARSH_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.109488 (rank : 187)
Query Neighborhood Hits	389	Target Neighborhood Hits	768	Shared Neighborhood Hits	139
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TEC_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.066999 (rank : 353)
Query Neighborhood Hits	389	Target Neighborhood Hits	1006	Shared Neighborhood Hits	126
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.065553 (rank : 367)
Query Neighborhood Hits	389	Target Neighborhood Hits	1006	Shared Neighborhood Hits	125
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TENS4_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.054110 (rank : 478)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TIAM1_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.074033 (rank : 308)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.073256 (rank : 316)
Query Neighborhood Hits	389	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TM108_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.050529 (rank : 511)
Query Neighborhood Hits	389	Target Neighborhood Hits	336	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TPO_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.050727 (rank : 509)
Query Neighborhood Hits	389	Target Neighborhood Hits	258	Shared Neighborhood Hits	59
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

TXK_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.065359 (rank : 368)
Query Neighborhood Hits	389	Target Neighborhood Hits	971	Shared Neighborhood Hits	115
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.070693 (rank : 332)
Query Neighborhood Hits	389	Target Neighborhood Hits	980	Shared Neighborhood Hits	127
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TXND2_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.068956 (rank : 339)
Query Neighborhood Hits	389	Target Neighborhood Hits	793	Shared Neighborhood Hits	83
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

VASP_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.052342 (rank : 494)
Query Neighborhood Hits	389	Target Neighborhood Hits	201	Shared Neighborhood Hits	45
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

WASF1_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.054222 (rank : 477)
Query Neighborhood Hits	389	Target Neighborhood Hits	260	Shared Neighborhood Hits	48
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.057095 (rank : 447)
Query Neighborhood Hits	389	Target Neighborhood Hits	261	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

WASF3_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.055334 (rank : 468)
Query Neighborhood Hits	389	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

WASIP_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.111565 (rank : 185)
Query Neighborhood Hits	389	Target Neighborhood Hits	458	Shared Neighborhood Hits	81
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASP_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.052144 (rank : 498)
Query Neighborhood Hits	389	Target Neighborhood Hits	195	Shared Neighborhood Hits	46
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

YLPM1_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.078321 (rank : 290)
Query Neighborhood Hits	389	Target Neighborhood Hits	505	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZIMP7_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.062726 (rank : 390)
Query Neighborhood Hits	389	Target Neighborhood Hits	566	Shared Neighborhood Hits	99
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

Hits sorted by NC score

EFS_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	389	Target Neighborhood Hits	389	Shared Neighborhood Hits	389
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EFS_HUMAN
NC score	0.907693 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	389	Target Neighborhood Hits	348	Shared Neighborhood Hits	213
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

BCAR1_MOUSE
NC score	0.732342 (rank : 3)	θ value	2.68423e-28 (rank : 4)
Query Neighborhood Hits	389	Target Neighborhood Hits	438	Shared Neighborhood Hits	213
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_HUMAN
NC score	0.719967 (rank : 4)	θ value	5.40856e-29 (rank : 3)
Query Neighborhood Hits	389	Target Neighborhood Hits	554	Shared Neighborhood Hits	231
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_MOUSE
NC score	0.709061 (rank : 5)	θ value	1.37858e-24 (rank : 6)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	145
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.701900 (rank : 6)	θ value	1.05554e-24 (rank : 5)
Query Neighborhood Hits	389	Target Neighborhood Hits	259	Shared Neighborhood Hits	150
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CT032_HUMAN
NC score	0.668363 (rank : 7)	θ value	1.29331e-14 (rank : 7)
Query Neighborhood Hits	389	Target Neighborhood Hits	235	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PEX13_HUMAN
NC score	0.491014 (rank : 8)	θ value	3.41135e-07 (rank : 8)
Query Neighborhood Hits	389	Target Neighborhood Hits	128	Shared Neighborhood Hits	110
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
NC score	0.486404 (rank : 9)	θ value	3.41135e-07 (rank : 9)
Query Neighborhood Hits	389	Target Neighborhood Hits	126	Shared Neighborhood Hits	108
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CD2AP_MOUSE
NC score	0.466437 (rank : 10)	θ value	0.00020696 (rank : 23)
Query Neighborhood Hits	389	Target Neighborhood Hits	336	Shared Neighborhood Hits	166
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

VINEX_MOUSE
NC score	0.465832 (rank : 11)	θ value	2.21117e-06 (rank : 13)
Query Neighborhood Hits	389	Target Neighborhood Hits	286	Shared Neighborhood Hits	165
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

PPIP1_HUMAN
NC score	0.458005 (rank : 12)	θ value	4.92598e-06 (rank : 15)
Query Neighborhood Hits	389	Target Neighborhood Hits	389	Shared Neighborhood Hits	164
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

VINEX_HUMAN
NC score	0.456197 (rank : 13)	θ value	4.92598e-06 (rank : 16)
Query Neighborhood Hits	389	Target Neighborhood Hits	270	Shared Neighborhood Hits	158
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PPIP1_MOUSE
NC score	0.450517 (rank : 14)	θ value	5.44631e-05 (rank : 19)
Query Neighborhood Hits	389	Target Neighborhood Hits	377	Shared Neighborhood Hits	163
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CD2AP_HUMAN
NC score	0.445274 (rank : 15)	θ value	0.0148317 (rank : 67)
Query Neighborhood Hits	389	Target Neighborhood Hits	315	Shared Neighborhood Hits	157
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.444925 (rank : 16)	θ value	0.000270298 (rank : 27)
Query Neighborhood Hits	389	Target Neighborhood Hits	332	Shared Neighborhood Hits	155
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.444755 (rank : 17)	θ value	0.000602161 (rank : 32)
Query Neighborhood Hits	389	Target Neighborhood Hits	341	Shared Neighborhood Hits	153
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

HCLS1_HUMAN
NC score	0.420400 (rank : 18)	θ value	0.00869519 (rank : 60)
Query Neighborhood Hits	389	Target Neighborhood Hits	358	Shared Neighborhood Hits	180
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF2_HUMAN
NC score	0.417971 (rank : 19)	θ value	0.00390308 (rank : 48)
Query Neighborhood Hits	389	Target Neighborhood Hits	229	Shared Neighborhood Hits	137
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

HCLS1_MOUSE
NC score	0.406499 (rank : 20)	θ value	0.0736092 (rank : 88)
Query Neighborhood Hits	389	Target Neighborhood Hits	329	Shared Neighborhood Hits	176
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRBS1_MOUSE
NC score	0.399535 (rank : 21)	θ value	0.0563607 (rank : 86)
Query Neighborhood Hits	389	Target Neighborhood Hits	409	Shared Neighborhood Hits	178
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G2_MOUSE
NC score	0.395338 (rank : 22)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	389	Target Neighborhood Hits	319	Shared Neighborhood Hits	154
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI2_HUMAN
NC score	0.391683 (rank : 23)	θ value	0.0563607 (rank : 81)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	170
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NCF4_MOUSE
NC score	0.389128 (rank : 24)	θ value	0.0113563 (rank : 65)
Query Neighborhood Hits	389	Target Neighborhood Hits	177	Shared Neighborhood Hits	124
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRB2_HUMAN
NC score	0.389088 (rank : 25)	θ value	0.00020696 (rank : 24)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	164
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.388478 (rank : 26)	θ value	0.00020696 (rank : 25)
Query Neighborhood Hits	389	Target Neighborhood Hits	312	Shared Neighborhood Hits	164
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SRBS1_HUMAN
NC score	0.387267 (rank : 27)	θ value	0.0736092 (rank : 90)
Query Neighborhood Hits	389	Target Neighborhood Hits	396	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G2_HUMAN
NC score	0.385029 (rank : 28)	θ value	0.00665767 (rank : 59)
Query Neighborhood Hits	389	Target Neighborhood Hits	324	Shared Neighborhood Hits	150
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ABI2_MOUSE
NC score	0.383850 (rank : 29)	θ value	0.0563607 (rank : 82)
Query Neighborhood Hits	389	Target Neighborhood Hits	266	Shared Neighborhood Hits	152
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PACN1_MOUSE
NC score	0.383442 (rank : 30)	θ value	0.00390308 (rank : 50)
Query Neighborhood Hits	389	Target Neighborhood Hits	283	Shared Neighborhood Hits	146
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.382437 (rank : 31)	θ value	0.00390308 (rank : 49)
Query Neighborhood Hits	389	Target Neighborhood Hits	320	Shared Neighborhood Hits	147
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

GRAP2_MOUSE
NC score	0.382263 (rank : 32)	θ value	0.0113563 (rank : 63)
Query Neighborhood Hits	389	Target Neighborhood Hits	297	Shared Neighborhood Hits	163
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PACN2_HUMAN
NC score	0.382000 (rank : 33)	θ value	0.00298849 (rank : 46)
Query Neighborhood Hits	389	Target Neighborhood Hits	339	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.377965 (rank : 34)	θ value	0.00509761 (rank : 54)
Query Neighborhood Hits	389	Target Neighborhood Hits	382	Shared Neighborhood Hits	155
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NCK1_HUMAN
NC score	0.376828 (rank : 35)	θ value	0.0113563 (rank : 66)
Query Neighborhood Hits	389	Target Neighborhood Hits	312	Shared Neighborhood Hits	163
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.375041 (rank : 36)	θ value	0.000602161 (rank : 31)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	165
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PACN3_MOUSE
NC score	0.373521 (rank : 37)	θ value	0.00509761 (rank : 55)
Query Neighborhood Hits	389	Target Neighborhood Hits	380	Shared Neighborhood Hits	144
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NCF4_HUMAN
NC score	0.372518 (rank : 38)	θ value	0.00509761 (rank : 53)
Query Neighborhood Hits	389	Target Neighborhood Hits	161	Shared Neighborhood Hits	114
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN3_HUMAN
NC score	0.371201 (rank : 39)	θ value	0.00665767 (rank : 58)
Query Neighborhood Hits	389	Target Neighborhood Hits	385	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

RUSC1_HUMAN
NC score	0.371007 (rank : 40)	θ value	5.44631e-05 (rank : 20)
Query Neighborhood Hits	389	Target Neighborhood Hits	226	Shared Neighborhood Hits	127
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

GRAP2_HUMAN
NC score	0.369924 (rank : 41)	θ value	0.0193708 (rank : 73)
Query Neighborhood Hits	389	Target Neighborhood Hits	304	Shared Neighborhood Hits	164
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH3G1_MOUSE
NC score	0.368990 (rank : 42)	θ value	0.0563607 (rank : 83)
Query Neighborhood Hits	389	Target Neighborhood Hits	291	Shared Neighborhood Hits	150
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

GRAP_MOUSE
NC score	0.368450 (rank : 43)	θ value	0.00665767 (rank : 57)
Query Neighborhood Hits	389	Target Neighborhood Hits	309	Shared Neighborhood Hits	164
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SH3G3_HUMAN
NC score	0.367403 (rank : 44)	θ value	0.163984 (rank : 111)
Query Neighborhood Hits	389	Target Neighborhood Hits	222	Shared Neighborhood Hits	147
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
NC score	0.363281 (rank : 45)	θ value	0.813845 (rank : 183)
Query Neighborhood Hits	389	Target Neighborhood Hits	236	Shared Neighborhood Hits	151
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

GRAP_HUMAN
NC score	0.362495 (rank : 46)	θ value	0.0113563 (rank : 64)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SRC8_HUMAN
NC score	0.362266 (rank : 47)	θ value	1.06291 (rank : 196)
Query Neighborhood Hits	389	Target Neighborhood Hits	269	Shared Neighborhood Hits	150
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.362101 (rank : 48)	θ value	1.06291 (rank : 197)
Query Neighborhood Hits	389	Target Neighborhood Hits	292	Shared Neighborhood Hits	151
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

DNMBP_HUMAN
NC score	0.360237 (rank : 49)	θ value	0.00298849 (rank : 43)
Query Neighborhood Hits	389	Target Neighborhood Hits	413	Shared Neighborhood Hits	166
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF1_HUMAN
NC score	0.352801 (rank : 50)	θ value	0.62314 (rank : 159)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	132
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ABI1_MOUSE
NC score	0.352491 (rank : 51)	θ value	0.279714 (rank : 125)
Query Neighborhood Hits	389	Target Neighborhood Hits	246	Shared Neighborhood Hits	145
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G1_HUMAN
NC score	0.345175 (rank : 52)	θ value	1.06291 (rank : 195)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	149
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

IASPP_HUMAN
NC score	0.344989 (rank : 53)	θ value	3.77169e-06 (rank : 14)
Query Neighborhood Hits	389	Target Neighborhood Hits	688	Shared Neighborhood Hits	177
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NCF1_MOUSE
NC score	0.344280 (rank : 54)	θ value	1.38821 (rank : 212)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	137
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

IASPP_MOUSE
NC score	0.343998 (rank : 55)	θ value	1.69304e-06 (rank : 11)
Query Neighborhood Hits	389	Target Neighborhood Hits	1024	Shared Neighborhood Hits	234
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DNMBP_MOUSE
NC score	0.340747 (rank : 56)	θ value	0.0961366 (rank : 93)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	176
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RUSC1_MOUSE
NC score	0.340317 (rank : 57)	θ value	0.000270298 (rank : 26)
Query Neighborhood Hits	389	Target Neighborhood Hits	206	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ABI1_HUMAN
NC score	0.340094 (rank : 58)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	389	Target Neighborhood Hits	257	Shared Neighborhood Hits	155
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CRKL_HUMAN
NC score	0.337730 (rank : 59)	θ value	0.125558 (rank : 101)
Query Neighborhood Hits	389	Target Neighborhood Hits	313	Shared Neighborhood Hits	161
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.328615 (rank : 60)	θ value	0.47712 (rank : 140)
Query Neighborhood Hits	389	Target Neighborhood Hits	314	Shared Neighborhood Hits	162
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ARHG7_HUMAN
NC score	0.327708 (rank : 61)	θ value	0.125558 (rank : 98)
Query Neighborhood Hits	389	Target Neighborhood Hits	347	Shared Neighborhood Hits	154
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.326647 (rank : 62)	θ value	0.125558 (rank : 99)
Query Neighborhood Hits	389	Target Neighborhood Hits	396	Shared Neighborhood Hits	157
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

SNX18_MOUSE
NC score	0.321682 (rank : 63)	θ value	0.000602161 (rank : 33)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	121
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.312744 (rank : 64)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	389	Target Neighborhood Hits	207	Shared Neighborhood Hits	124
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

STAM2_MOUSE
NC score	0.312563 (rank : 65)	θ value	0.62314 (rank : 165)
Query Neighborhood Hits	389	Target Neighborhood Hits	285	Shared Neighborhood Hits	153
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CRK_HUMAN
NC score	0.312112 (rank : 66)	θ value	0.21417 (rank : 115)
Query Neighborhood Hits	389	Target Neighborhood Hits	308	Shared Neighborhood Hits	161
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

VAV_HUMAN
NC score	0.310023 (rank : 67)	θ value	0.00298849 (rank : 47)
Query Neighborhood Hits	389	Target Neighborhood Hits	452	Shared Neighborhood Hits	157
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

STAM1_MOUSE
NC score	0.308814 (rank : 68)	θ value	6.88961 (rank : 353)
Query Neighborhood Hits	389	Target Neighborhood Hits	273	Shared Neighborhood Hits	157
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.308721 (rank : 69)	θ value	6.88961 (rank : 352)
Query Neighborhood Hits	389	Target Neighborhood Hits	271	Shared Neighborhood Hits	154
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NPHP1_MOUSE
NC score	0.307855 (rank : 70)	θ value	0.365318 (rank : 133)
Query Neighborhood Hits	389	Target Neighborhood Hits	267	Shared Neighborhood Hits	140
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

VAV_MOUSE
NC score	0.305763 (rank : 71)	θ value	0.00869519 (rank : 62)
Query Neighborhood Hits	389	Target Neighborhood Hits	430	Shared Neighborhood Hits	155
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CRKL_MOUSE
NC score	0.302937 (rank : 72)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	156
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

AHI1_HUMAN
NC score	0.300231 (rank : 73)	θ value	0.00102713 (rank : 34)
Query Neighborhood Hits	389	Target Neighborhood Hits	537	Shared Neighborhood Hits	156
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.294978 (rank : 74)	θ value	0.000602161 (rank : 28)
Query Neighborhood Hits	389	Target Neighborhood Hits	496	Shared Neighborhood Hits	156
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

LASP1_HUMAN
NC score	0.291997 (rank : 75)	θ value	0.47712 (rank : 145)
Query Neighborhood Hits	389	Target Neighborhood Hits	293	Shared Neighborhood Hits	134
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

STAC_HUMAN
NC score	0.291663 (rank : 76)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	389	Target Neighborhood Hits	276	Shared Neighborhood Hits	141
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM2_HUMAN
NC score	0.291222 (rank : 77)	θ value	1.38821 (rank : 221)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	151
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

LASP1_MOUSE
NC score	0.289278 (rank : 78)	θ value	0.47712 (rank : 146)
Query Neighborhood Hits	389	Target Neighborhood Hits	297	Shared Neighborhood Hits	132
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG6_MOUSE
NC score	0.287357 (rank : 79)	θ value	2.36792 (rank : 244)
Query Neighborhood Hits	389	Target Neighborhood Hits	394	Shared Neighborhood Hits	149
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NEBL_HUMAN
NC score	0.284111 (rank : 80)	θ value	0.163984 (rank : 109)
Query Neighborhood Hits	389	Target Neighborhood Hits	457	Shared Neighborhood Hits	135
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ITSN2_HUMAN
NC score	0.283812 (rank : 81)	θ value	0.00298849 (rank : 44)
Query Neighborhood Hits	389	Target Neighborhood Hits	1173	Shared Neighborhood Hits	180
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ABI3_MOUSE
NC score	0.283305 (rank : 82)	θ value	1.81305 (rank : 223)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN1_HUMAN
NC score	0.281896 (rank : 83)	θ value	0.00134147 (rank : 36)
Query Neighborhood Hits	389	Target Neighborhood Hits	1757	Shared Neighborhood Hits	225
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ABI3_HUMAN
NC score	0.281121 (rank : 84)	θ value	2.36792 (rank : 243)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	134
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN1_MOUSE
NC score	0.280540 (rank : 85)	θ value	0.000602161 (rank : 30)
Query Neighborhood Hits	389	Target Neighborhood Hits	1669	Shared Neighborhood Hits	212
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG6_HUMAN
NC score	0.277846 (rank : 86)	θ value	8.99809 (rank : 360)
Query Neighborhood Hits	389	Target Neighborhood Hits	376	Shared Neighborhood Hits	148
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

STAC_MOUSE
NC score	0.277504 (rank : 87)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	389	Target Neighborhood Hits	268	Shared Neighborhood Hits	138
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

OSTF1_MOUSE
NC score	0.276854 (rank : 88)	θ value	0.62314 (rank : 160)
Query Neighborhood Hits	389	Target Neighborhood Hits	467	Shared Neighborhood Hits	156
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ASPP1_MOUSE
NC score	0.276306 (rank : 89)	θ value	0.0193708 (rank : 71)
Query Neighborhood Hits	389	Target Neighborhood Hits	1244	Shared Neighborhood Hits	233
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

OSTF1_HUMAN
NC score	0.276147 (rank : 90)	θ value	2.36792 (rank : 256)
Query Neighborhood Hits	389	Target Neighborhood Hits	466	Shared Neighborhood Hits	155
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

NPHP1_HUMAN
NC score	0.275548 (rank : 91)	θ value	1.38821 (rank : 213)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	133
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ASPP1_HUMAN
NC score	0.273519 (rank : 92)	θ value	0.00509761 (rank : 51)
Query Neighborhood Hits	389	Target Neighborhood Hits	956	Shared Neighborhood Hits	171
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ITSN2_MOUSE
NC score	0.267324 (rank : 93)	θ value	0.0193708 (rank : 74)
Query Neighborhood Hits	389	Target Neighborhood Hits	1371	Shared Neighborhood Hits	186
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NOXO1_MOUSE
NC score	0.257374 (rank : 94)	θ value	0.365318 (rank : 132)
Query Neighborhood Hits	389	Target Neighborhood Hits	114	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ES8L3_MOUSE
NC score	0.256038 (rank : 95)	θ value	0.0736092 (rank : 87)
Query Neighborhood Hits	389	Target Neighborhood Hits	168	Shared Neighborhood Hits	121
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

DBNL_HUMAN
NC score	0.255450 (rank : 96)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	389	Target Neighborhood Hits	244	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

VAV2_HUMAN
NC score	0.254590 (rank : 97)	θ value	0.21417 (rank : 122)
Query Neighborhood Hits	389	Target Neighborhood Hits	453	Shared Neighborhood Hits	157
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.253700 (rank : 98)	θ value	0.47712 (rank : 152)
Query Neighborhood Hits	389	Target Neighborhood Hits	456	Shared Neighborhood Hits	157
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DBNL_MOUSE
NC score	0.253308 (rank : 99)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	389	Target Neighborhood Hits	306	Shared Neighborhood Hits	135
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NEBU_HUMAN
NC score	0.247530 (rank : 100)	θ value	0.163984 (rank : 110)
Query Neighborhood Hits	389	Target Neighborhood Hits	420	Shared Neighborhood Hits	139
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RIMB2_HUMAN
NC score	0.246906 (rank : 101)	θ value	0.125558 (rank : 104)
Query Neighborhood Hits	389	Target Neighborhood Hits	263	Shared Neighborhood Hits	107
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

VAV3_HUMAN
NC score	0.241345 (rank : 102)	θ value	1.81305 (rank : 239)
Query Neighborhood Hits	389	Target Neighborhood Hits	398	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

RIMB2_MOUSE
NC score	0.240133 (rank : 103)	θ value	0.813845 (rank : 181)
Query Neighborhood Hits	389	Target Neighborhood Hits	246	Shared Neighborhood Hits	100
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC2_HUMAN
NC score	0.239928 (rank : 104)	θ value	0.000121331 (rank : 22)
Query Neighborhood Hits	389	Target Neighborhood Hits	205	Shared Neighborhood Hits	75
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RHG04_HUMAN
NC score	0.238420 (rank : 105)	θ value	0.00228821 (rank : 41)
Query Neighborhood Hits	389	Target Neighborhood Hits	307	Shared Neighborhood Hits	138
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

VAV3_MOUSE
NC score	0.234054 (rank : 106)	θ value	4.03905 (rank : 309)
Query Neighborhood Hits	389	Target Neighborhood Hits	404	Shared Neighborhood Hits	153
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ES8L2_HUMAN
NC score	0.229697 (rank : 107)	θ value	0.0252991 (rank : 75)
Query Neighborhood Hits	389	Target Neighborhood Hits	193	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ARHG9_HUMAN
NC score	0.227309 (rank : 108)	θ value	1.38821 (rank : 203)
Query Neighborhood Hits	389	Target Neighborhood Hits	235	Shared Neighborhood Hits	132
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.226128 (rank : 109)	θ value	1.06291 (rank : 184)
Query Neighborhood Hits	389	Target Neighborhood Hits	234	Shared Neighborhood Hits	131
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ES8L2_MOUSE
NC score	0.219961 (rank : 110)	θ value	0.163984 (rank : 108)
Query Neighborhood Hits	389	Target Neighborhood Hits	169	Shared Neighborhood Hits	103
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SNX9_HUMAN
NC score	0.218666 (rank : 111)	θ value	0.125558 (rank : 105)
Query Neighborhood Hits	389	Target Neighborhood Hits	148	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

STAC3_MOUSE
NC score	0.217225 (rank : 112)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	389	Target Neighborhood Hits	232	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ASPP2_HUMAN
NC score	0.216418 (rank : 113)	θ value	0.21417 (rank : 113)
Query Neighborhood Hits	389	Target Neighborhood Hits	1156	Shared Neighborhood Hits	170
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

STAC3_HUMAN
NC score	0.216067 (rank : 114)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	125
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG4_HUMAN
NC score	0.215574 (rank : 115)	θ value	6.88961 (rank : 327)
Query Neighborhood Hits	389	Target Neighborhood Hits	242	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RUSC2_MOUSE
NC score	0.214013 (rank : 116)	θ value	0.0148317 (rank : 69)
Query Neighborhood Hits	389	Target Neighborhood Hits	305	Shared Neighborhood Hits	96
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

EPS8_MOUSE
NC score	0.207898 (rank : 117)	θ value	1.06291 (rank : 186)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L3_HUMAN
NC score	0.206547 (rank : 118)	θ value	2.36792 (rank : 249)
Query Neighborhood Hits	389	Target Neighborhood Hits	206	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NOXO1_HUMAN
NC score	0.204228 (rank : 119)	θ value	0.0961366 (rank : 95)
Query Neighborhood Hits	389	Target Neighborhood Hits	100	Shared Neighborhood Hits	76
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SNX9_MOUSE
NC score	0.204094 (rank : 120)	θ value	0.365318 (rank : 135)
Query Neighborhood Hits	389	Target Neighborhood Hits	141	Shared Neighborhood Hits	80
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

EPS8_HUMAN
NC score	0.203833 (rank : 121)	θ value	0.125558 (rank : 102)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	97
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

PLCG1_MOUSE
NC score	0.189849 (rank : 122)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	389	Target Neighborhood Hits	314	Shared Neighborhood Hits	137
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRGP2_MOUSE
NC score	0.189748 (rank : 123)	θ value	0.163984 (rank : 112)
Query Neighborhood Hits	389	Target Neighborhood Hits	324	Shared Neighborhood Hits	132
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ES8L1_HUMAN
NC score	0.188537 (rank : 124)	θ value	0.47712 (rank : 143)
Query Neighborhood Hits	389	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

RHG26_HUMAN
NC score	0.186975 (rank : 125)	θ value	0.21417 (rank : 120)
Query Neighborhood Hits	389	Target Neighborhood Hits	281	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L1_MOUSE
NC score	0.186512 (rank : 126)	θ value	1.06291 (rank : 187)
Query Neighborhood Hits	389	Target Neighborhood Hits	143	Shared Neighborhood Hits	83
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

TCGAP_HUMAN
NC score	0.184311 (rank : 127)	θ value	8.99809 (rank : 386)
Query Neighborhood Hits	389	Target Neighborhood Hits	872	Shared Neighborhood Hits	215
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRGP2_HUMAN
NC score	0.183862 (rank : 128)	θ value	0.47712 (rank : 150)
Query Neighborhood Hits	389	Target Neighborhood Hits	331	Shared Neighborhood Hits	133
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

PLCG2_HUMAN
NC score	0.183400 (rank : 129)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	389	Target Neighborhood Hits	280	Shared Neighborhood Hits	134
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

MYO1F_HUMAN
NC score	0.182888 (rank : 130)	θ value	0.00509761 (rank : 52)
Query Neighborhood Hits	389	Target Neighborhood Hits	275	Shared Neighborhood Hits	151
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.180853 (rank : 131)	θ value	0.00869519 (rank : 61)
Query Neighborhood Hits	389	Target Neighborhood Hits	262	Shared Neighborhood Hits	148
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PLCG1_HUMAN
NC score	0.180824 (rank : 132)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	389	Target Neighborhood Hits	293	Shared Neighborhood Hits	133
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB1_HUMAN
NC score	0.179501 (rank : 133)	θ value	0.0736092 (rank : 89)
Query Neighborhood Hits	389	Target Neighborhood Hits	1479	Shared Neighborhood Hits	204
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPTA2_HUMAN
NC score	0.177387 (rank : 134)	θ value	0.00102713 (rank : 35)
Query Neighborhood Hits	389	Target Neighborhood Hits	888	Shared Neighborhood Hits	152
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

OGFR_HUMAN
NC score	0.165643 (rank : 135)	θ value	0.00298849 (rank : 45)
Query Neighborhood Hits	389	Target Neighborhood Hits	1582	Shared Neighborhood Hits	194
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MYO1E_HUMAN
NC score	0.161812 (rank : 136)	θ value	0.47712 (rank : 147)
Query Neighborhood Hits	389	Target Neighborhood Hits	293	Shared Neighborhood Hits	149
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PRRT3_HUMAN
NC score	0.161083 (rank : 137)	θ value	1.38821 (rank : 216)
Query Neighborhood Hits	389	Target Neighborhood Hits	998	Shared Neighborhood Hits	170
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SPTA1_HUMAN
NC score	0.160830 (rank : 138)	θ value	0.0563607 (rank : 85)
Query Neighborhood Hits	389	Target Neighborhood Hits	748	Shared Neighborhood Hits	143
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP1_HUMAN
NC score	0.159731 (rank : 139)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	389	Target Neighborhood Hits	390	Shared Neighborhood Hits	129
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

BAT2_HUMAN
NC score	0.158977 (rank : 140)	θ value	0.00665767 (rank : 56)
Query Neighborhood Hits	389	Target Neighborhood Hits	931	Shared Neighborhood Hits	129
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

TCGAP_MOUSE
NC score	0.157451 (rank : 141)	θ value	8.99809 (rank : 387)
Query Neighborhood Hits	389	Target Neighborhood Hits	409	Shared Neighborhood Hits	149
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ARHG4_MOUSE
NC score	0.154302 (rank : 142)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	389	Target Neighborhood Hits	185	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ANM2_HUMAN
NC score	0.154179 (rank : 143)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	389	Target Neighborhood Hits	175	Shared Neighborhood Hits	123
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FNBP2_HUMAN
NC score	0.154023 (rank : 144)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	389	Target Neighborhood Hits	432	Shared Neighborhood Hits	138
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SF3A1_MOUSE
NC score	0.153753 (rank : 145)	θ value	4.1701e-05 (rank : 18)
Query Neighborhood Hits	389	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

SHAN2_MOUSE
NC score	0.150981 (rank : 146)	θ value	0.0961366 (rank : 96)
Query Neighborhood Hits	389	Target Neighborhood Hits	446	Shared Neighborhood Hits	125
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHLB1_MOUSE
NC score	0.150088 (rank : 147)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	389	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SPTA1_MOUSE
NC score	0.149744 (rank : 148)	θ value	3.0926 (rank : 276)
Query Neighborhood Hits	389	Target Neighborhood Hits	675	Shared Neighborhood Hits	142
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ANM2_MOUSE
NC score	0.148710 (rank : 149)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	389	Target Neighborhood Hits	175	Shared Neighborhood Hits	119
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CS016_HUMAN
NC score	0.146595 (rank : 150)	θ value	0.000602161 (rank : 29)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

SF3A1_HUMAN
NC score	0.145641 (rank : 151)	θ value	9.29e-05 (rank : 21)
Query Neighborhood Hits	389	Target Neighborhood Hits	199	Shared Neighborhood Hits	31
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

NACAM_MOUSE
NC score	0.145316 (rank : 152)	θ value	0.279714 (rank : 126)
Query Neighborhood Hits	389	Target Neighborhood Hits	1866	Shared Neighborhood Hits	202
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

RIMB1_MOUSE
NC score	0.144918 (rank : 153)	θ value	0.279714 (rank : 127)
Query Neighborhood Hits	389	Target Neighborhood Hits	1376	Shared Neighborhood Hits	179
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SHLB1_HUMAN
NC score	0.144415 (rank : 154)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	389	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

DDEF1_MOUSE
NC score	0.143088 (rank : 155)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	389	Target Neighborhood Hits	592	Shared Neighborhood Hits	151
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

BAT2_MOUSE
NC score	0.141748 (rank : 156)	θ value	0.0193708 (rank : 72)
Query Neighborhood Hits	389	Target Neighborhood Hits	947	Shared Neighborhood Hits	123
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SPN90_HUMAN
NC score	0.139582 (rank : 157)	θ value	1.38821 (rank : 220)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

DDEF2_MOUSE
NC score	0.138397 (rank : 158)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	389	Target Neighborhood Hits	625	Shared Neighborhood Hits	144
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.138046 (rank : 159)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	389	Target Neighborhood Hits	599	Shared Neighborhood Hits	145
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SON_HUMAN
NC score	0.136992 (rank : 160)	θ value	0.47712 (rank : 149)
Query Neighborhood Hits	389	Target Neighborhood Hits	1568	Shared Neighborhood Hits	176
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

M3KL4_HUMAN
NC score	0.134567 (rank : 161)	θ value	1.29631e-06 (rank : 10)
Query Neighborhood Hits	389	Target Neighborhood Hits	1087	Shared Neighborhood Hits	159
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MUC1_HUMAN
NC score	0.134371 (rank : 162)	θ value	4.1701e-05 (rank : 17)
Query Neighborhood Hits	389	Target Neighborhood Hits	975	Shared Neighborhood Hits	142
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

TROAP_HUMAN
NC score	0.128648 (rank : 163)	θ value	0.21417 (rank : 121)
Query Neighborhood Hits	389	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

RGS3_MOUSE
NC score	0.128327 (rank : 164)	θ value	5.27518 (rank : 322)
Query Neighborhood Hits	389	Target Neighborhood Hits	1621	Shared Neighborhood Hits	188
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SHAN1_HUMAN
NC score	0.127954 (rank : 165)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	389	Target Neighborhood Hits	1041	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

M3K11_HUMAN
NC score	0.126856 (rank : 166)	θ value	0.00175202 (rank : 40)
Query Neighborhood Hits	389	Target Neighborhood Hits	1136	Shared Neighborhood Hits	177
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RAPH1_HUMAN
NC score	0.126412 (rank : 167)	θ value	1.38821 (rank : 217)
Query Neighborhood Hits	389	Target Neighborhood Hits	593	Shared Neighborhood Hits	98
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

PRP2_MOUSE
NC score	0.119384 (rank : 168)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	389	Target Neighborhood Hits	347	Shared Neighborhood Hits	64
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

TAF4_HUMAN
NC score	0.119298 (rank : 169)	θ value	1.81305 (rank : 238)
Query Neighborhood Hits	389	Target Neighborhood Hits	687	Shared Neighborhood Hits	94
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

SHLB2_MOUSE
NC score	0.119273 (rank : 170)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	389	Target Neighborhood Hits	88	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

GSCR1_HUMAN
NC score	0.119223 (rank : 171)	θ value	0.21417 (rank : 117)
Query Neighborhood Hits	389	Target Neighborhood Hits	674	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

P85A_MOUSE
NC score	0.118318 (rank : 172)	θ value	3.0926 (rank : 271)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	100
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHLB2_HUMAN
NC score	0.117893 (rank : 173)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	389	Target Neighborhood Hits	86	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

CIP4_HUMAN
NC score	0.116702 (rank : 174)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	389	Target Neighborhood Hits	374	Shared Neighborhood Hits	75
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CN155_HUMAN
NC score	0.113632 (rank : 175)	θ value	0.125558 (rank : 100)
Query Neighborhood Hits	389	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

SPN90_MOUSE
NC score	0.113287 (rank : 176)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ARHG5_HUMAN
NC score	0.113049 (rank : 177)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	389	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

M3K9_HUMAN
NC score	0.113021 (rank : 178)	θ value	0.0431538 (rank : 79)
Query Neighborhood Hits	389	Target Neighborhood Hits	1123	Shared Neighborhood Hits	168
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

NGEF_MOUSE
NC score	0.112885 (rank : 179)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

P85A_HUMAN
NC score	0.112824 (rank : 180)	θ value	4.03905 (rank : 298)
Query Neighborhood Hits	389	Target Neighborhood Hits	479	Shared Neighborhood Hits	95
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

WASIP_MOUSE
NC score	0.112685 (rank : 181)	θ value	6.88961 (rank : 354)
Query Neighborhood Hits	389	Target Neighborhood Hits	392	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

BCL9_HUMAN
NC score	0.112638 (rank : 182)	θ value	0.62314 (rank : 153)
Query Neighborhood Hits	389	Target Neighborhood Hits	1008	Shared Neighborhood Hits	144
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BSN_MOUSE
NC score	0.112427 (rank : 183)	θ value	3.0926 (rank : 263)
Query Neighborhood Hits	389	Target Neighborhood Hits	2057	Shared Neighborhood Hits	196
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

LCP2_HUMAN
NC score	0.111780 (rank : 184)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	389	Target Neighborhood Hits	531	Shared Neighborhood Hits	128
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

WASIP_HUMAN
NC score	0.111565 (rank : 185)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	389	Target Neighborhood Hits	458	Shared Neighborhood Hits	81
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

MUC7_HUMAN
NC score	0.110822 (rank : 186)	θ value	1.06291 (rank : 193)
Query Neighborhood Hits	389	Target Neighborhood Hits	538	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

TARSH_HUMAN
NC score	0.109488 (rank : 187)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	389	Target Neighborhood Hits	768	Shared Neighborhood Hits	139
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

STS2_HUMAN
NC score	0.109373 (rank : 188)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	389	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

AMPH_HUMAN
NC score	0.108934 (rank : 189)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	389	Target Neighborhood Hits	455	Shared Neighborhood Hits	115
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

BIN1_HUMAN
NC score	0.108904 (rank : 190)	θ value	6.88961 (rank : 329)
Query Neighborhood Hits	389	Target Neighborhood Hits	335	Shared Neighborhood Hits	95
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

PCLO_HUMAN
NC score	0.108452 (rank : 191)	θ value	0.365318 (rank : 134)
Query Neighborhood Hits	389	Target Neighborhood Hits	2046	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PRR12_HUMAN
NC score	0.108271 (rank : 192)	θ value	8.99809 (rank : 378)
Query Neighborhood Hits	389	Target Neighborhood Hits	460	Shared Neighborhood Hits	82
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

NGEF_HUMAN
NC score	0.107560 (rank : 193)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	389	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MAGE1_HUMAN
NC score	0.107295 (rank : 194)	θ value	1.38821 (rank : 211)
Query Neighborhood Hits	389	Target Neighborhood Hits	1389	Shared Neighborhood Hits	172
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PRP1_HUMAN
NC score	0.107292 (rank : 195)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	389	Target Neighborhood Hits	385	Shared Neighborhood Hits	62
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

WBP11_HUMAN
NC score	0.106911 (rank : 196)	θ value	0.365318 (rank : 137)
Query Neighborhood Hits	389	Target Neighborhood Hits	354	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

ATN1_HUMAN
NC score	0.106446 (rank : 197)	θ value	5.27518 (rank : 312)
Query Neighborhood Hits	389	Target Neighborhood Hits	676	Shared Neighborhood Hits	91
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

M3K10_HUMAN
NC score	0.105476 (rank : 198)	θ value	0.0330416 (rank : 77)
Query Neighborhood Hits	389	Target Neighborhood Hits	1071	Shared Neighborhood Hits	154
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

SRC_HUMAN
NC score	0.105249 (rank : 199)	θ value	0.62314 (rank : 163)
Query Neighborhood Hits	389	Target Neighborhood Hits	1058	Shared Neighborhood Hits	165
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.105206 (rank : 200)	θ value	1.38821 (rank : 208)
Query Neighborhood Hits	389	Target Neighborhood Hits	1073	Shared Neighborhood Hits	166
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

CN032_HUMAN
NC score	0.104130 (rank : 201)	θ value	0.163984 (rank : 107)
Query Neighborhood Hits	389	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

MDC1_HUMAN
NC score	0.103516 (rank : 202)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	389	Target Neighborhood Hits	1446	Shared Neighborhood Hits	144
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SAPS1_HUMAN
NC score	0.103461 (rank : 203)	θ value	1.38821 (rank : 218)
Query Neighborhood Hits	389	Target Neighborhood Hits	704	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

FYN_HUMAN
NC score	0.102468 (rank : 204)	θ value	1.38821 (rank : 207)
Query Neighborhood Hits	389	Target Neighborhood Hits	1078	Shared Neighborhood Hits	165
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

NCOA6_HUMAN
NC score	0.102347 (rank : 205)	θ value	5.27518 (rank : 320)
Query Neighborhood Hits	389	Target Neighborhood Hits	1202	Shared Neighborhood Hits	162
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PCLO_MOUSE
NC score	0.102229 (rank : 206)	θ value	6.88961 (rank : 347)
Query Neighborhood Hits	389	Target Neighborhood Hits	2275	Shared Neighborhood Hits	196
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

YES_MOUSE
NC score	0.102189 (rank : 207)	θ value	3.0926 (rank : 281)
Query Neighborhood Hits	389	Target Neighborhood Hits	1052	Shared Neighborhood Hits	160
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SLAP2_HUMAN
NC score	0.102066 (rank : 208)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	389	Target Neighborhood Hits	139	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

YES_HUMAN
NC score	0.101838 (rank : 209)	θ value	3.0926 (rank : 280)
Query Neighborhood Hits	389	Target Neighborhood Hits	1059	Shared Neighborhood Hits	160
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

MBD6_HUMAN
NC score	0.101712 (rank : 210)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	389	Target Neighborhood Hits	349	Shared Neighborhood Hits	62
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

WBP11_MOUSE
NC score	0.101708 (rank : 211)	θ value	1.38821 (rank : 222)
Query Neighborhood Hits	389	Target Neighborhood Hits	362	Shared Neighborhood Hits	60
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

P85B_HUMAN
NC score	0.101089 (rank : 212)	θ value	3.0926 (rank : 272)
Query Neighborhood Hits	389	Target Neighborhood Hits	543	Shared Neighborhood Hits	81
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GGN_HUMAN
NC score	0.100611 (rank : 213)	θ value	0.47712 (rank : 144)
Query Neighborhood Hits	389	Target Neighborhood Hits	269	Shared Neighborhood Hits	59
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

MISS_MOUSE
NC score	0.100486 (rank : 214)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	389	Target Neighborhood Hits	444	Shared Neighborhood Hits	100
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

AUTS2_HUMAN
NC score	0.100353 (rank : 215)	θ value	0.00298849 (rank : 42)
Query Neighborhood Hits	389	Target Neighborhood Hits	342	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

SF3A2_HUMAN
NC score	0.100278 (rank : 216)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	389	Target Neighborhood Hits	263	Shared Neighborhood Hits	44
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

CBP_HUMAN
NC score	0.100071 (rank : 217)	θ value	0.0961366 (rank : 92)
Query Neighborhood Hits	389	Target Neighborhood Hits	941	Shared Neighborhood Hits	126
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

FGR_HUMAN
NC score	0.099704 (rank : 218)	θ value	8.99809 (rank : 365)
Query Neighborhood Hits	389	Target Neighborhood Hits	1067	Shared Neighborhood Hits	157
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLAP2_MOUSE
NC score	0.099338 (rank : 219)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	389	Target Neighborhood Hits	136	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

MLL3_HUMAN
NC score	0.099165 (rank : 220)	θ value	4.03905 (rank : 296)
Query Neighborhood Hits	389	Target Neighborhood Hits	1644	Shared Neighborhood Hits	164
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

FA47B_HUMAN
NC score	0.098847 (rank : 221)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	389	Target Neighborhood Hits	431	Shared Neighborhood Hits	99
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

CBP_MOUSE
NC score	0.098648 (rank : 222)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	389	Target Neighborhood Hits	1051	Shared Neighborhood Hits	139
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SF3A2_MOUSE
NC score	0.098421 (rank : 223)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	389	Target Neighborhood Hits	247	Shared Neighborhood Hits	44
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

LCP2_MOUSE
NC score	0.097939 (rank : 224)	θ value	0.0431538 (rank : 78)
Query Neighborhood Hits	389	Target Neighborhood Hits	177	Shared Neighborhood Hits	54
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CN032_MOUSE
NC score	0.097441 (rank : 225)	θ value	3.0926 (rank : 264)
Query Neighborhood Hits	389	Target Neighborhood Hits	233	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

BIN1_MOUSE
NC score	0.096892 (rank : 226)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	389	Target Neighborhood Hits	283	Shared Neighborhood Hits	93
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

FGR_MOUSE
NC score	0.096652 (rank : 227)	θ value	8.99809 (rank : 366)
Query Neighborhood Hits	389	Target Neighborhood Hits	1069	Shared Neighborhood Hits	158
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RGS3_HUMAN
NC score	0.095899 (rank : 228)	θ value	6.88961 (rank : 349)
Query Neighborhood Hits	389	Target Neighborhood Hits	1375	Shared Neighborhood Hits	172
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

WASL_MOUSE
NC score	0.095553 (rank : 229)	θ value	0.21417 (rank : 123)
Query Neighborhood Hits	389	Target Neighborhood Hits	339	Shared Neighborhood Hits	56
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

BTK_HUMAN
NC score	0.095492 (rank : 230)	θ value	2.36792 (rank : 245)
Query Neighborhood Hits	389	Target Neighborhood Hits	1026	Shared Neighborhood Hits	159
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

PRB4S_HUMAN
NC score	0.094914 (rank : 231)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	389	Target Neighborhood Hits	330	Shared Neighborhood Hits	56
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PPIP2_HUMAN
NC score	0.094821 (rank : 232)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	389	Target Neighborhood Hits	254	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

P85B_MOUSE
NC score	0.094687 (rank : 233)	θ value	4.03905 (rank : 299)
Query Neighborhood Hits	389	Target Neighborhood Hits	519	Shared Neighborhood Hits	77
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SRRM1_MOUSE
NC score	0.094604 (rank : 234)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	389	Target Neighborhood Hits	966	Shared Neighborhood Hits	131
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

GGN_MOUSE
NC score	0.094220 (rank : 235)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	389	Target Neighborhood Hits	311	Shared Neighborhood Hits	60
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

AMPH_MOUSE
NC score	0.093706 (rank : 236)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	389	Target Neighborhood Hits	291	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

HCK_HUMAN
NC score	0.093347 (rank : 237)	θ value	2.36792 (rank : 250)
Query Neighborhood Hits	389	Target Neighborhood Hits	1035	Shared Neighborhood Hits	152
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ENAH_MOUSE
NC score	0.092170 (rank : 238)	θ value	1.81305 (rank : 227)
Query Neighborhood Hits	389	Target Neighborhood Hits	919	Shared Neighborhood Hits	99
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

MCF2L_MOUSE
NC score	0.092050 (rank : 239)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	389	Target Neighborhood Hits	255	Shared Neighborhood Hits	49
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

JIP1_HUMAN
NC score	0.091700 (rank : 240)	θ value	5.27518 (rank : 316)
Query Neighborhood Hits	389	Target Neighborhood Hits	271	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

HCK_MOUSE
NC score	0.091414 (rank : 241)	θ value	3.0926 (rank : 267)
Query Neighborhood Hits	389	Target Neighborhood Hits	1029	Shared Neighborhood Hits	153
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MLL2_HUMAN
NC score	0.091290 (rank : 242)	θ value	0.21417 (rank : 118)
Query Neighborhood Hits	389	Target Neighborhood Hits	1788	Shared Neighborhood Hits	146
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SRC_MOUSE
NC score	0.091097 (rank : 243)	θ value	0.62314 (rank : 164)
Query Neighborhood Hits	389	Target Neighborhood Hits	1033	Shared Neighborhood Hits	146
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ARHGG_MOUSE
NC score	0.090767 (rank : 244)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	389	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SF01_HUMAN
NC score	0.090764 (rank : 245)	θ value	0.62314 (rank : 162)
Query Neighborhood Hits	389	Target Neighborhood Hits	287	Shared Neighborhood Hits	53
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

WIRE_HUMAN
NC score	0.089589 (rank : 246)	θ value	4.03905 (rank : 311)
Query Neighborhood Hits	389	Target Neighborhood Hits	329	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

PPIP2_MOUSE
NC score	0.089477 (rank : 247)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	389	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

RERE_HUMAN
NC score	0.089476 (rank : 248)	θ value	1.81305 (rank : 234)
Query Neighborhood Hits	389	Target Neighborhood Hits	779	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

NCOA6_MOUSE
NC score	0.088979 (rank : 249)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	389	Target Neighborhood Hits	1076	Shared Neighborhood Hits	138
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

STS1_HUMAN
NC score	0.088773 (rank : 250)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	389	Target Neighborhood Hits	106	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.088239 (rank : 251)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	389	Target Neighborhood Hits	104	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

YLPM1_HUMAN
NC score	0.088083 (rank : 252)	θ value	0.62314 (rank : 166)
Query Neighborhood Hits	389	Target Neighborhood Hits	670	Shared Neighborhood Hits	80
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

BTK_MOUSE
NC score	0.087654 (rank : 253)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	389	Target Neighborhood Hits	1017	Shared Neighborhood Hits	150
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RERE_MOUSE
NC score	0.087631 (rank : 254)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	389	Target Neighborhood Hits	785	Shared Neighborhood Hits	87
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

EP300_HUMAN
NC score	0.087244 (rank : 255)	θ value	0.813845 (rank : 174)
Query Neighborhood Hits	389	Target Neighborhood Hits	821	Shared Neighborhood Hits	97
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

CK024_HUMAN
NC score	0.087085 (rank : 256)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	389	Target Neighborhood Hits	408	Shared Neighborhood Hits	84
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

JIP1_MOUSE
NC score	0.086959 (rank : 257)	θ value	3.0926 (rank : 269)
Query Neighborhood Hits	389	Target Neighborhood Hits	259	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SLAP1_HUMAN
NC score	0.086880 (rank : 258)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	389	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

MDC1_MOUSE
NC score	0.086849 (rank : 259)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	389	Target Neighborhood Hits	998	Shared Neighborhood Hits	126
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

DOCK1_HUMAN
NC score	0.086749 (rank : 260)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	389	Target Neighborhood Hits	191	Shared Neighborhood Hits	101
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SRRM2_MOUSE
NC score	0.086537 (rank : 261)	θ value	8.99809 (rank : 385)
Query Neighborhood Hits	389	Target Neighborhood Hits	1470	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CRSP2_HUMAN
NC score	0.086208 (rank : 262)	θ value	2.36792 (rank : 246)
Query Neighborhood Hits	389	Target Neighborhood Hits	380	Shared Neighborhood Hits	82
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

PELP1_MOUSE
NC score	0.085727 (rank : 263)	θ value	6.88961 (rank : 348)
Query Neighborhood Hits	389	Target Neighborhood Hits	709	Shared Neighborhood Hits	105
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

FGD1_MOUSE
NC score	0.085673 (rank : 264)	θ value	0.00175202 (rank : 39)
Query Neighborhood Hits	389	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

WIRE_MOUSE
NC score	0.085546 (rank : 265)	θ value	6.88961 (rank : 355)
Query Neighborhood Hits	389	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

K1802_MOUSE
NC score	0.085528 (rank : 266)	θ value	8.99809 (rank : 374)
Query Neighborhood Hits	389	Target Neighborhood Hits	1596	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

WASL_HUMAN
NC score	0.085417 (rank : 267)	θ value	3.0926 (rank : 279)
Query Neighborhood Hits	389	Target Neighborhood Hits	312	Shared Neighborhood Hits	56
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

FRK_HUMAN
NC score	0.085410 (rank : 268)	θ value	6.88961 (rank : 337)
Query Neighborhood Hits	389	Target Neighborhood Hits	1058	Shared Neighborhood Hits	159
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SLAP1_MOUSE
NC score	0.084959 (rank : 269)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	389	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SON_MOUSE
NC score	0.084929 (rank : 270)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	389	Target Neighborhood Hits	957	Shared Neighborhood Hits	117
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

PI5PA_HUMAN
NC score	0.084764 (rank : 271)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	389	Target Neighborhood Hits	749	Shared Neighborhood Hits	134
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

LYN_MOUSE
NC score	0.084580 (rank : 272)	θ value	1.38821 (rank : 210)
Query Neighborhood Hits	389	Target Neighborhood Hits	1023	Shared Neighborhood Hits	144
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PHC2_HUMAN
NC score	0.084083 (rank : 273)	θ value	1.38821 (rank : 214)
Query Neighborhood Hits	389	Target Neighborhood Hits	388	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

BCL9_MOUSE
NC score	0.083988 (rank : 274)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	389	Target Neighborhood Hits	770	Shared Neighborhood Hits	124
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

LYN_HUMAN
NC score	0.083964 (rank : 275)	θ value	2.36792 (rank : 253)
Query Neighborhood Hits	389	Target Neighborhood Hits	1022	Shared Neighborhood Hits	144
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SELPL_MOUSE
NC score	0.083960 (rank : 276)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	389	Target Neighborhood Hits	588	Shared Neighborhood Hits	93
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

CEL_HUMAN
NC score	0.083706 (rank : 277)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	389	Target Neighborhood Hits	896	Shared Neighborhood Hits	140
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

BLNK_MOUSE
NC score	0.083657 (rank : 278)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	389	Target Neighborhood Hits	296	Shared Neighborhood Hits	81
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CIC_HUMAN
NC score	0.082398 (rank : 279)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	389	Target Neighborhood Hits	992	Shared Neighborhood Hits	145
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

BSN_HUMAN
NC score	0.082201 (rank : 280)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	389	Target Neighborhood Hits	1537	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

MLL4_HUMAN
NC score	0.081765 (rank : 281)	θ value	0.21417 (rank : 119)
Query Neighborhood Hits	389	Target Neighborhood Hits	722	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

FMN2_HUMAN
NC score	0.081735 (rank : 282)	θ value	1.38821 (rank : 206)
Query Neighborhood Hits	389	Target Neighborhood Hits	484	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FGD1_HUMAN
NC score	0.080932 (rank : 283)	θ value	0.365318 (rank : 130)
Query Neighborhood Hits	389	Target Neighborhood Hits	367	Shared Neighborhood Hits	55
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GA2L2_MOUSE
NC score	0.080090 (rank : 284)	θ value	0.21417 (rank : 116)
Query Neighborhood Hits	389	Target Neighborhood Hits	395	Shared Neighborhood Hits	92
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

JIP2_HUMAN
NC score	0.080085 (rank : 285)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	83
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

PRB3_HUMAN
NC score	0.080077 (rank : 286)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	389	Target Neighborhood Hits	318	Shared Neighborhood Hits	51
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

MLL3_MOUSE
NC score	0.080060 (rank : 287)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	389	Target Neighborhood Hits	1399	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SFPQ_MOUSE
NC score	0.079827 (rank : 288)	θ value	0.279714 (rank : 128)
Query Neighborhood Hits	389	Target Neighborhood Hits	958	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SLY_MOUSE
NC score	0.078509 (rank : 289)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	389	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

YLPM1_MOUSE
NC score	0.078321 (rank : 290)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	389	Target Neighborhood Hits	505	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SF01_MOUSE
NC score	0.078282 (rank : 291)	θ value	2.36792 (rank : 259)
Query Neighborhood Hits	389	Target Neighborhood Hits	240	Shared Neighborhood Hits	43
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

ARHGG_HUMAN
NC score	0.078140 (rank : 292)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	389	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

APS_HUMAN
NC score	0.077755 (rank : 293)	θ value	4.03905 (rank : 284)
Query Neighborhood Hits	389	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

RASA1_HUMAN
NC score	0.077344 (rank : 294)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	389	Target Neighborhood Hits	258	Shared Neighborhood Hits	61
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

BLK_HUMAN
NC score	0.077338 (rank : 295)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	389	Target Neighborhood Hits	994	Shared Neighborhood Hits	131
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BAG3_MOUSE
NC score	0.076778 (rank : 296)	θ value	8.99809 (rank : 361)
Query Neighborhood Hits	389	Target Neighborhood Hits	513	Shared Neighborhood Hits	98
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PKHG1_HUMAN
NC score	0.076426 (rank : 297)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	389	Target Neighborhood Hits	174	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ABL1_MOUSE
NC score	0.075371 (rank : 298)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	389	Target Neighborhood Hits	1178	Shared Neighborhood Hits	144
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SFPQ_HUMAN
NC score	0.074914 (rank : 299)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	389	Target Neighborhood Hits	986	Shared Neighborhood Hits	88
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

PREX1_HUMAN
NC score	0.074889 (rank : 300)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	389	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SRRM1_HUMAN
NC score	0.074632 (rank : 301)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	389	Target Neighborhood Hits	690	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SYNJ1_HUMAN
NC score	0.074500 (rank : 302)	θ value	0.47712 (rank : 151)
Query Neighborhood Hits	389	Target Neighborhood Hits	498	Shared Neighborhood Hits	85
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

ABL1_HUMAN
NC score	0.074432 (rank : 303)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	389	Target Neighborhood Hits	1220	Shared Neighborhood Hits	152
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FMNL_HUMAN
NC score	0.074321 (rank : 304)	θ value	1.06291 (rank : 188)
Query Neighborhood Hits	389	Target Neighborhood Hits	529	Shared Neighborhood Hits	70
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

BLK_MOUSE
NC score	0.074313 (rank : 305)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	389	Target Neighborhood Hits	992	Shared Neighborhood Hits	121
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CO039_MOUSE
NC score	0.074187 (rank : 306)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	389	Target Neighborhood Hits	445	Shared Neighborhood Hits	99
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

ARHG3_HUMAN
NC score	0.074047 (rank : 307)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	389	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

TIAM1_HUMAN
NC score	0.074033 (rank : 308)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG3_MOUSE
NC score	0.073858 (rank : 309)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	389	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

SH21B_MOUSE
NC score	0.073829 (rank : 310)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	389	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SYP2L_HUMAN
NC score	0.073475 (rank : 311)	θ value	0.0736092 (rank : 91)
Query Neighborhood Hits	389	Target Neighborhood Hits	400	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PSL1_HUMAN
NC score	0.073414 (rank : 312)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	389	Target Neighborhood Hits	650	Shared Neighborhood Hits	126
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

SH21B_HUMAN
NC score	0.073370 (rank : 313)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	389	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ARHGF_HUMAN
NC score	0.073322 (rank : 314)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	389	Target Neighborhood Hits	214	Shared Neighborhood Hits	54
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PTK6_HUMAN
NC score	0.073292 (rank : 315)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	389	Target Neighborhood Hits	1020	Shared Neighborhood Hits	143
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TIAM1_MOUSE
NC score	0.073256 (rank : 316)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	389	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

NFH_MOUSE
NC score	0.072653 (rank : 317)	θ value	0.0961366 (rank : 94)
Query Neighborhood Hits	389	Target Neighborhood Hits	2247	Shared Neighborhood Hits	172
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SPT5H_HUMAN
NC score	0.072605 (rank : 318)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	389	Target Neighborhood Hits	436	Shared Neighborhood Hits	81
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

WASF2_MOUSE
NC score	0.072542 (rank : 319)	θ value	4.03905 (rank : 310)
Query Neighborhood Hits	389	Target Neighborhood Hits	315	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

SPT5H_MOUSE
NC score	0.072341 (rank : 320)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	389	Target Neighborhood Hits	437	Shared Neighborhood Hits	80
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

CSK_MOUSE
NC score	0.072144 (rank : 321)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	389	Target Neighborhood Hits	1009	Shared Neighborhood Hits	129
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.071958 (rank : 322)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	389	Target Neighborhood Hits	1009	Shared Neighborhood Hits	129
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

DAPP1_HUMAN
NC score	0.071935 (rank : 323)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PTK6_MOUSE
NC score	0.071899 (rank : 324)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	389	Target Neighborhood Hits	1026	Shared Neighborhood Hits	139
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

BRD4_HUMAN
NC score	0.071617 (rank : 325)	θ value	0.62314 (rank : 154)
Query Neighborhood Hits	389	Target Neighborhood Hits	851	Shared Neighborhood Hits	82
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

ARI1A_HUMAN
NC score	0.071570 (rank : 326)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	389	Target Neighborhood Hits	787	Shared Neighborhood Hits	101
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

P55G_HUMAN
NC score	0.071471 (rank : 327)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	389	Target Neighborhood Hits	451	Shared Neighborhood Hits	53
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
NC score	0.071467 (rank : 328)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

WASF2_HUMAN
NC score	0.071049 (rank : 329)	θ value	3.0926 (rank : 278)
Query Neighborhood Hits	389	Target Neighborhood Hits	280	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

BI2L1_HUMAN
NC score	0.071025 (rank : 330)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	389	Target Neighborhood Hits	156	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SPR1B_MOUSE
NC score	0.070930 (rank : 331)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	389	Target Neighborhood Hits	395	Shared Neighborhood Hits	85
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

TXK_MOUSE
NC score	0.070693 (rank : 332)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	389	Target Neighborhood Hits	980	Shared Neighborhood Hits	127
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

P55G_MOUSE
NC score	0.070616 (rank : 333)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	389	Target Neighborhood Hits	401	Shared Neighborhood Hits	51
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

BRD4_MOUSE
NC score	0.070355 (rank : 334)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	389	Target Neighborhood Hits	845	Shared Neighborhood Hits	77
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CDAN1_HUMAN
NC score	0.069683 (rank : 335)	θ value	1.81305 (rank : 224)
Query Neighborhood Hits	389	Target Neighborhood Hits	92	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IWY9, Q7Z7L5, Q969N3	Gene names	CDAN1
Domain Architecture	No domain graphic available
Description	Codanin-1.

MUCDL_HUMAN
NC score	0.069579 (rank : 336)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	389	Target Neighborhood Hits	777	Shared Neighborhood Hits	116
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SYN1_HUMAN
NC score	0.069454 (rank : 337)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	389	Target Neighborhood Hits	419	Shared Neighborhood Hits	72
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

GRB14_MOUSE
NC score	0.069417 (rank : 338)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	389	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

TXND2_HUMAN
NC score	0.068956 (rank : 339)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	389	Target Neighborhood Hits	793	Shared Neighborhood Hits	83
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

MILK1_MOUSE
NC score	0.068603 (rank : 340)	θ value	6.88961 (rank : 344)
Query Neighborhood Hits	389	Target Neighborhood Hits	788	Shared Neighborhood Hits	129
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SRRM2_HUMAN
NC score	0.068509 (rank : 341)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	389	Target Neighborhood Hits	1296	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SYNJ1_MOUSE
NC score	0.068347 (rank : 342)	θ value	1.81305 (rank : 236)
Query Neighborhood Hits	389	Target Neighborhood Hits	516	Shared Neighborhood Hits	89
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

T22D4_HUMAN
NC score	0.068226 (rank : 343)	θ value	1.06291 (rank : 198)
Query Neighborhood Hits	389	Target Neighborhood Hits	403	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

LCK_HUMAN
NC score	0.068151 (rank : 344)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	389	Target Neighborhood Hits	987	Shared Neighborhood Hits	114
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SC24C_HUMAN
NC score	0.068040 (rank : 345)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	389	Target Neighborhood Hits	662	Shared Neighborhood Hits	111
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

GRB14_HUMAN
NC score	0.068009 (rank : 346)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	389	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ARHG8_HUMAN
NC score	0.067853 (rank : 347)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	389	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

LR37A_HUMAN
NC score	0.067829 (rank : 348)	θ value	0.813845 (rank : 178)
Query Neighborhood Hits	389	Target Neighborhood Hits	720	Shared Neighborhood Hits	76
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

SRMS_MOUSE
NC score	0.067759 (rank : 349)	θ value	0.0431538 (rank : 80)
Query Neighborhood Hits	389	Target Neighborhood Hits	964	Shared Neighborhood Hits	103
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

REPS2_MOUSE
NC score	0.067686 (rank : 350)	θ value	0.813845 (rank : 180)
Query Neighborhood Hits	389	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

LCK_MOUSE
NC score	0.067323 (rank : 351)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	389	Target Neighborhood Hits	981	Shared Neighborhood Hits	112
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LPP_HUMAN
NC score	0.067257 (rank : 352)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	389	Target Neighborhood Hits	775	Shared Neighborhood Hits	132
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

TEC_HUMAN
NC score	0.066999 (rank : 353)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	389	Target Neighborhood Hits	1006	Shared Neighborhood Hits	126
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CPSF6_MOUSE
NC score	0.066761 (rank : 354)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	389	Target Neighborhood Hits	356	Shared Neighborhood Hits	54
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

SLY_HUMAN
NC score	0.066612 (rank : 355)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	389	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

NUMBL_HUMAN
NC score	0.066489 (rank : 356)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	389	Target Neighborhood Hits	394	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

JIP2_MOUSE
NC score	0.066287 (rank : 357)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	389	Target Neighborhood Hits	144	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ARHGA_MOUSE
NC score	0.066261 (rank : 358)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	389	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CPSF6_HUMAN
NC score	0.066063 (rank : 359)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	389	Target Neighborhood Hits	359	Shared Neighborhood Hits	53
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CSKI1_HUMAN
NC score	0.066027 (rank : 360)	θ value	0.813845 (rank : 171)
Query Neighborhood Hits	389	Target Neighborhood Hits	997	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FA47A_HUMAN
NC score	0.066022 (rank : 361)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	389	Target Neighborhood Hits	451	Shared Neighborhood Hits	86
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

K1802_HUMAN
NC score	0.066015 (rank : 362)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	389	Target Neighborhood Hits	1378	Shared Neighborhood Hits	140
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LNK_HUMAN
NC score	0.065981 (rank : 363)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ARHG8_MOUSE
NC score	0.065944 (rank : 364)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	389	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

SHD_HUMAN
NC score	0.065902 (rank : 365)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	389	Target Neighborhood Hits	204	Shared Neighborhood Hits	55
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ITK_HUMAN
NC score	0.065566 (rank : 366)	θ value	6.88961 (rank : 339)
Query Neighborhood Hits	389	Target Neighborhood Hits	1016	Shared Neighborhood Hits	123
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TEC_MOUSE
NC score	0.065553 (rank : 367)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	389	Target Neighborhood Hits	1006	Shared Neighborhood Hits	125
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.065359 (rank : 368)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	389	Target Neighborhood Hits	971	Shared Neighborhood Hits	115
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

WASF4_HUMAN
NC score	0.065317 (rank : 369)	θ value	2.36792 (rank : 262)
Query Neighborhood Hits	389	Target Neighborhood Hits	282	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

BAIP2_MOUSE
NC score	0.064889 (rank : 370)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	389	Target Neighborhood Hits	185	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ABL2_HUMAN
NC score	0.064861 (rank : 371)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	389	Target Neighborhood Hits	1045	Shared Neighborhood Hits	121
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SSBP4_HUMAN
NC score	0.064820 (rank : 372)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	389	Target Neighborhood Hits	753	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

GRB7_MOUSE
NC score	0.064749 (rank : 373)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	389	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

BI2L1_MOUSE
NC score	0.064736 (rank : 374)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	389	Target Neighborhood Hits	197	Shared Neighborhood Hits	58
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CABIN_HUMAN
NC score	0.064601 (rank : 375)	θ value	5.27518 (rank : 313)
Query Neighborhood Hits	389	Target Neighborhood Hits	490	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

MKL1_MOUSE
NC score	0.064517 (rank : 376)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	389	Target Neighborhood Hits	667	Shared Neighborhood Hits	116
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

ECT2_MOUSE
NC score	0.064193 (rank : 377)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	389	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

CSKI1_MOUSE
NC score	0.063786 (rank : 378)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	389	Target Neighborhood Hits	1031	Shared Neighborhood Hits	151
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CD2_HUMAN
NC score	0.063644 (rank : 379)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	389	Target Neighborhood Hits	504	Shared Neighborhood Hits	87
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

PCQAP_HUMAN
NC score	0.063624 (rank : 380)	θ value	3.0926 (rank : 273)
Query Neighborhood Hits	389	Target Neighborhood Hits	549	Shared Neighborhood Hits	64
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

MNT_HUMAN
NC score	0.063587 (rank : 381)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	389	Target Neighborhood Hits	496	Shared Neighborhood Hits	83
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

PRG4_HUMAN
NC score	0.063529 (rank : 382)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	389	Target Neighborhood Hits	764	Shared Neighborhood Hits	75
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

FGD3_MOUSE
NC score	0.063519 (rank : 383)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	389	Target Neighborhood Hits	257	Shared Neighborhood Hits	28
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

BAIP2_HUMAN
NC score	0.063244 (rank : 384)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	389	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

CCNK_MOUSE
NC score	0.063025 (rank : 385)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	53
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

FMN1B_MOUSE
NC score	0.063008 (rank : 386)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	389	Target Neighborhood Hits	447	Shared Neighborhood Hits	68
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

SHE_MOUSE
NC score	0.062841 (rank : 387)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	389	Target Neighborhood Hits	169	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHB_MOUSE
NC score	0.062794 (rank : 388)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	389	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

REPS2_HUMAN
NC score	0.062761 (rank : 389)	θ value	4.03905 (rank : 303)
Query Neighborhood Hits	389	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ZIMP7_MOUSE
NC score	0.062726 (rank : 390)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	389	Target Neighborhood Hits	566	Shared Neighborhood Hits	99
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

TENS4_HUMAN
NC score	0.062669 (rank : 391)	θ value	1.06291 (rank : 201)
Query Neighborhood Hits	389	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

ARHGA_HUMAN
NC score	0.062128 (rank : 392)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	389	Target Neighborhood Hits	187	Shared Neighborhood Hits	25
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SNPC4_HUMAN
NC score	0.062098 (rank : 393)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	389	Target Neighborhood Hits	589	Shared Neighborhood Hits	105
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

COG8_MOUSE
NC score	0.061963 (rank : 394)	θ value	0.47712 (rank : 139)
Query Neighborhood Hits	389	Target Neighborhood Hits	147	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

ARHGB_HUMAN
NC score	0.061842 (rank : 395)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	389	Target Neighborhood Hits	375	Shared Neighborhood Hits	45
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

3BP1_HUMAN
NC score	0.061646 (rank : 396)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	389	Target Neighborhood Hits	376	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

SELV_HUMAN
NC score	0.061436 (rank : 397)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	389	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

SHC1_HUMAN
NC score	0.061416 (rank : 398)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	389	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

MTSS1_MOUSE
NC score	0.061391 (rank : 399)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	389	Target Neighborhood Hits	592	Shared Neighborhood Hits	95
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MINT_MOUSE
NC score	0.061341 (rank : 400)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	389	Target Neighborhood Hits	1514	Shared Neighborhood Hits	146
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SHB_HUMAN
NC score	0.061319 (rank : 401)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	389	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

FGD3_HUMAN
NC score	0.061285 (rank : 402)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	389	Target Neighborhood Hits	249	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ECT2_HUMAN
NC score	0.061256 (rank : 403)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	389	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SHE_HUMAN
NC score	0.061207 (rank : 404)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	389	Target Neighborhood Hits	164	Shared Neighborhood Hits	46
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MCF2_HUMAN
NC score	0.061196 (rank : 405)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	389	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

SHC3_MOUSE
NC score	0.061062 (rank : 406)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

K1543_HUMAN
NC score	0.061031 (rank : 407)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	85
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

FMN1A_MOUSE
NC score	0.060921 (rank : 408)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	389	Target Neighborhood Hits	423	Shared Neighborhood Hits	64
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

ARHG1_MOUSE
NC score	0.060849 (rank : 409)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	389	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGC_HUMAN
NC score	0.060586 (rank : 410)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	389	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GRB10_MOUSE
NC score	0.060544 (rank : 411)	θ value	8.99809 (rank : 369)
Query Neighborhood Hits	389	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB7_HUMAN
NC score	0.060251 (rank : 412)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	389	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

TARA_HUMAN
NC score	0.060134 (rank : 413)	θ value	4.03905 (rank : 306)
Query Neighborhood Hits	389	Target Neighborhood Hits	1626	Shared Neighborhood Hits	144
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ARHGC_MOUSE
NC score	0.060027 (rank : 414)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	389	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MAVS_HUMAN
NC score	0.059893 (rank : 415)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	389	Target Neighborhood Hits	271	Shared Neighborhood Hits	47
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

SC24A_MOUSE
NC score	0.059859 (rank : 416)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	389	Target Neighborhood Hits	394	Shared Neighborhood Hits	91
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SHD_MOUSE
NC score	0.059658 (rank : 417)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	389	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SYN1_MOUSE
NC score	0.059530 (rank : 418)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	389	Target Neighborhood Hits	363	Shared Neighborhood Hits	60
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

AB1IP_HUMAN
NC score	0.059396 (rank : 419)	θ value	0.279714 (rank : 124)
Query Neighborhood Hits	389	Target Neighborhood Hits	213	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

LNK_MOUSE
NC score	0.059289 (rank : 420)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	389	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

BLNK_HUMAN
NC score	0.059263 (rank : 421)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

ARHG1_HUMAN
NC score	0.059255 (rank : 422)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	389	Target Neighborhood Hits	176	Shared Neighborhood Hits	26
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

CIC_MOUSE
NC score	0.059150 (rank : 423)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	389	Target Neighborhood Hits	742	Shared Neighborhood Hits	105
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

PRGC2_HUMAN
NC score	0.059032 (rank : 424)	θ value	0.62314 (rank : 161)
Query Neighborhood Hits	389	Target Neighborhood Hits	272	Shared Neighborhood Hits	48
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

BCR_HUMAN
NC score	0.059031 (rank : 425)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	389	Target Neighborhood Hits	204	Shared Neighborhood Hits	42
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

DIAP1_HUMAN
NC score	0.059014 (rank : 426)	θ value	4.03905 (rank : 289)
Query Neighborhood Hits	389	Target Neighborhood Hits	784	Shared Neighborhood Hits	69
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

PDC6I_HUMAN
NC score	0.058880 (rank : 427)	θ value	1.06291 (rank : 194)
Query Neighborhood Hits	389	Target Neighborhood Hits	278	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

STAR8_HUMAN
NC score	0.058697 (rank : 428)	θ value	0.125558 (rank : 106)
Query Neighborhood Hits	389	Target Neighborhood Hits	216	Shared Neighborhood Hits	38
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CI079_HUMAN
NC score	0.058674 (rank : 429)	θ value	1.81305 (rank : 225)
Query Neighborhood Hits	389	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

BASP_MOUSE
NC score	0.058570 (rank : 430)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	389	Target Neighborhood Hits	260	Shared Neighborhood Hits	29
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

SRMS_HUMAN
NC score	0.058467 (rank : 431)	θ value	1.81305 (rank : 235)
Query Neighborhood Hits	389	Target Neighborhood Hits	946	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FGD2_HUMAN
NC score	0.058355 (rank : 432)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	389	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.057810 (rank : 433)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	389	Target Neighborhood Hits	219	Shared Neighborhood Hits	24
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

SHC1_MOUSE
NC score	0.057797 (rank : 434)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	389	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ITK_MOUSE
NC score	0.057715 (rank : 435)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	389	Target Neighborhood Hits	985	Shared Neighborhood Hits	110
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

FMN2_MOUSE
NC score	0.057628 (rank : 436)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	389	Target Neighborhood Hits	349	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

CO039_HUMAN
NC score	0.057524 (rank : 437)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	389	Target Neighborhood Hits	264	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

SASH1_HUMAN
NC score	0.057522 (rank : 438)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	389	Target Neighborhood Hits	292	Shared Neighborhood Hits	85
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

ANK2_HUMAN
NC score	0.057509 (rank : 439)	θ value	0.125558 (rank : 97)
Query Neighborhood Hits	389	Target Neighborhood Hits	1615	Shared Neighborhood Hits	146
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

FGD4_MOUSE
NC score	0.057461 (rank : 440)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	389	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

K0310_HUMAN
NC score	0.057436 (rank : 441)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	389	Target Neighborhood Hits	420	Shared Neighborhood Hits	81
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

SET1A_HUMAN
NC score	0.057355 (rank : 442)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	389	Target Neighborhood Hits	690	Shared Neighborhood Hits	72
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SYP2L_MOUSE
NC score	0.057344 (rank : 443)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	389	Target Neighborhood Hits	289	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

APS_MOUSE
NC score	0.057275 (rank : 444)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	389	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

RGNEF_MOUSE
NC score	0.057246 (rank : 445)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	389	Target Neighborhood Hits	641	Shared Neighborhood Hits	50
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

MUC2_HUMAN
NC score	0.057155 (rank : 446)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	389	Target Neighborhood Hits	906	Shared Neighborhood Hits	77
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

WASF1_MOUSE
NC score	0.057095 (rank : 447)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	389	Target Neighborhood Hits	261	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

FGD2_MOUSE
NC score	0.057036 (rank : 448)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	389	Target Neighborhood Hits	163	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

GPS2_HUMAN
NC score	0.056888 (rank : 449)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	389	Target Neighborhood Hits	459	Shared Neighborhood Hits	52
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

SHC3_HUMAN
NC score	0.056628 (rank : 450)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	389	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

DLG5_HUMAN
NC score	0.056601 (rank : 451)	θ value	0.47712 (rank : 142)
Query Neighborhood Hits	389	Target Neighborhood Hits	1088	Shared Neighborhood Hits	96
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

GRB10_HUMAN
NC score	0.056351 (rank : 452)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	389	Target Neighborhood Hits	147	Shared Neighborhood Hits	45
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

ENAH_HUMAN
NC score	0.056341 (rank : 453)	θ value	3.0926 (rank : 266)
Query Neighborhood Hits	389	Target Neighborhood Hits	784	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

MUC1_MOUSE
NC score	0.056229 (rank : 454)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	389	Target Neighborhood Hits	388	Shared Neighborhood Hits	35
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

SHC2_MOUSE
NC score	0.056140 (rank : 455)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	389	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

CDN1C_HUMAN
NC score	0.056046 (rank : 456)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	389	Target Neighborhood Hits	168	Shared Neighborhood Hits	43
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

PCQAP_MOUSE
NC score	0.055916 (rank : 457)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	389	Target Neighborhood Hits	506	Shared Neighborhood Hits	60
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

ZN385_HUMAN
NC score	0.055894 (rank : 458)	θ value	5.27518 (rank : 325)
Query Neighborhood Hits	389	Target Neighborhood Hits	614	Shared Neighborhood Hits	93
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

JPH2_HUMAN
NC score	0.055793 (rank : 459)	θ value	1.81305 (rank : 230)
Query Neighborhood Hits	389	Target Neighborhood Hits	639	Shared Neighborhood Hits	114
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

S3TC1_HUMAN
NC score	0.055752 (rank : 460)	θ value	3.0926 (rank : 275)
Query Neighborhood Hits	389	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

FMNL_MOUSE
NC score	0.055726 (rank : 461)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	389	Target Neighborhood Hits	428	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

BAT3_HUMAN
NC score	0.055698 (rank : 462)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	389	Target Neighborhood Hits	490	Shared Neighborhood Hits	85
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

SHC2_HUMAN
NC score	0.055667 (rank : 463)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	389	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

MATK_HUMAN
NC score	0.055595 (rank : 464)	θ value	1.06291 (rank : 190)
Query Neighborhood Hits	389	Target Neighborhood Hits	954	Shared Neighborhood Hits	79
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ALEX_HUMAN
NC score	0.055580 (rank : 465)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	389	Target Neighborhood Hits	361	Shared Neighborhood Hits	67
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

SASH1_MOUSE
NC score	0.055574 (rank : 466)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	389	Target Neighborhood Hits	263	Shared Neighborhood Hits	72
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

T22D2_HUMAN
NC score	0.055346 (rank : 467)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	389	Target Neighborhood Hits	250	Shared Neighborhood Hits	45
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

WASF3_HUMAN
NC score	0.055334 (rank : 468)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	389	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

LBC_HUMAN
NC score	0.055312 (rank : 469)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	389	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

S23IP_MOUSE
NC score	0.055149 (rank : 470)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	389	Target Neighborhood Hits	363	Shared Neighborhood Hits	69
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

PRPC_HUMAN
NC score	0.054647 (rank : 471)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	389	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

BAT3_MOUSE
NC score	0.054581 (rank : 472)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	389	Target Neighborhood Hits	518	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

HSH2D_HUMAN
NC score	0.054569 (rank : 473)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	389	Target Neighborhood Hits	159	Shared Neighborhood Hits	42
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ATX2L_HUMAN
NC score	0.054422 (rank : 474)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	389	Target Neighborhood Hits	443	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

MEF2B_MOUSE
NC score	0.054395 (rank : 475)	θ value	1.06291 (rank : 191)
Query Neighborhood Hits	389	Target Neighborhood Hits	218	Shared Neighborhood Hits	47
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

ZIM10_HUMAN
NC score	0.054361 (rank : 476)	θ value	1.81305 (rank : 240)
Query Neighborhood Hits	389	Target Neighborhood Hits	577	Shared Neighborhood Hits	91
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

WASF1_HUMAN
NC score	0.054222 (rank : 477)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	389	Target Neighborhood Hits	260	Shared Neighborhood Hits	48
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

TENS4_MOUSE
NC score	0.054110 (rank : 478)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

SYNPO_MOUSE
NC score	0.054030 (rank : 479)	θ value	1.81305 (rank : 237)
Query Neighborhood Hits	389	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

IF4G1_MOUSE
NC score	0.053980 (rank : 480)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	389	Target Neighborhood Hits	534	Shared Neighborhood Hits	96
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

MATK_MOUSE
NC score	0.053912 (rank : 481)	θ value	8.99809 (rank : 376)
Query Neighborhood Hits	389	Target Neighborhood Hits	952	Shared Neighborhood Hits	82
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ATX2_MOUSE
NC score	0.053521 (rank : 482)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	389	Target Neighborhood Hits	445	Shared Neighborhood Hits	78
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

DGKK_HUMAN
NC score	0.053517 (rank : 483)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	389	Target Neighborhood Hits	378	Shared Neighborhood Hits	55
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

MNT_MOUSE
NC score	0.053483 (rank : 484)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	389	Target Neighborhood Hits	432	Shared Neighborhood Hits	62
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

EM55_HUMAN
NC score	0.053326 (rank : 485)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	389	Target Neighborhood Hits	228	Shared Neighborhood Hits	83
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SH22A_MOUSE
NC score	0.053252 (rank : 486)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	389	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

CSKI2_MOUSE
NC score	0.053097 (rank : 487)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	389	Target Neighborhood Hits	812	Shared Neighborhood Hits	111
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

HAPIP_HUMAN
NC score	0.053016 (rank : 488)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

WNK2_HUMAN
NC score	0.052968 (rank : 489)	θ value	0.365318 (rank : 138)
Query Neighborhood Hits	389	Target Neighborhood Hits	1407	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

PO121_MOUSE
NC score	0.052922 (rank : 490)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	389	Target Neighborhood Hits	345	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

IRS2_HUMAN
NC score	0.052763 (rank : 491)	θ value	0.62314 (rank : 157)
Query Neighborhood Hits	389	Target Neighborhood Hits	262	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

SPR1A_MOUSE
NC score	0.052732 (rank : 492)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	389	Target Neighborhood Hits	343	Shared Neighborhood Hits	74
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

MYO15_HUMAN
NC score	0.052724 (rank : 493)	θ value	1.81305 (rank : 232)
Query Neighborhood Hits	389	Target Neighborhood Hits	671	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

VASP_HUMAN
NC score	0.052342 (rank : 494)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	389	Target Neighborhood Hits	201	Shared Neighborhood Hits	45
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

PELP1_HUMAN
NC score	0.052230 (rank : 495)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	389	Target Neighborhood Hits	596	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

K1543_MOUSE
NC score	0.052202 (rank : 496)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	389	Target Neighborhood Hits	497	Shared Neighborhood Hits	91
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

CJ078_MOUSE
NC score	0.052188 (rank : 497)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	389	Target Neighborhood Hits	559	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

WASP_HUMAN
NC score	0.052144 (rank : 498)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	389	Target Neighborhood Hits	195	Shared Neighborhood Hits	46
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

FGD6_MOUSE
NC score	0.051971 (rank : 499)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	389	Target Neighborhood Hits	282	Shared Neighborhood Hits	35
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SH21A_MOUSE
NC score	0.051865 (rank : 500)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	389	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

FYB_HUMAN
NC score	0.051814 (rank : 501)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	389	Target Neighborhood Hits	379	Shared Neighborhood Hits	68
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

EM55_MOUSE
NC score	0.051648 (rank : 502)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	389	Target Neighborhood Hits	221	Shared Neighborhood Hits	78
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ATX2L_MOUSE
NC score	0.051432 (rank : 503)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	389	Target Neighborhood Hits	401	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

SH21A_HUMAN
NC score	0.051394 (rank : 504)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	389	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

PI5PA_MOUSE
NC score	0.051288 (rank : 505)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	389	Target Neighborhood Hits	331	Shared Neighborhood Hits	74
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

ARI1B_HUMAN
NC score	0.051129 (rank : 506)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	389	Target Neighborhood Hits	567	Shared Neighborhood Hits	75
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

ARHG2_HUMAN
NC score	0.050893 (rank : 507)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	389	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ABR_HUMAN
NC score	0.050751 (rank : 508)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	389	Target Neighborhood Hits	166	Shared Neighborhood Hits	34
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

TPO_MOUSE
NC score	0.050727 (rank : 509)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	389	Target Neighborhood Hits	258	Shared Neighborhood Hits	59
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

PTN23_MOUSE
NC score	0.050708 (rank : 510)	θ value	0.47712 (rank : 148)
Query Neighborhood Hits	389	Target Neighborhood Hits	726	Shared Neighborhood Hits	86
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

TM108_MOUSE
NC score	0.050529 (rank : 511)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	389	Target Neighborhood Hits	336	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

SEPT9_HUMAN
NC score	0.050254 (rank : 512)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	389	Target Neighborhood Hits	706	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

RTP3_MOUSE
NC score	0.050236 (rank : 513)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	389	Target Neighborhood Hits	374	Shared Neighborhood Hits	66
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

R3HD2_MOUSE
NC score	0.050136 (rank : 514)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	389	Target Neighborhood Hits	397	Shared Neighborhood Hits	65
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

CECR2_HUMAN
NC score	0.050073 (rank : 515)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	389	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

IQEC2_MOUSE
NC score	0.049086 (rank : 516)	θ value	0.813845 (rank : 177)
Query Neighborhood Hits	389	Target Neighborhood Hits	417	Shared Neighborhood Hits	62
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_HUMAN
NC score	0.048565 (rank : 517)	θ value	0.813845 (rank : 176)
Query Neighborhood Hits	389	Target Neighborhood Hits	403	Shared Neighborhood Hits	61
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

GNAS1_MOUSE
NC score	0.048395 (rank : 518)	θ value	8.99809 (rank : 368)
Query Neighborhood Hits	389	Target Neighborhood Hits	651	Shared Neighborhood Hits	102
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

C1QBP_MOUSE
NC score	0.047861 (rank : 519)	θ value	0.21417 (rank : 114)
Query Neighborhood Hits	389	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O35658	Gene names	C1qbp, Gc1qbp
Domain Architecture
Description	Complement component 1 Q subcomponent-binding protein, mitochondrial precursor (Glycoprotein gC1qBP) (C1qBP) (GC1q-R protein).

DIAP1_MOUSE
NC score	0.047396 (rank : 520)	θ value	2.36792 (rank : 247)
Query Neighborhood Hits	389	Target Neighborhood Hits	839	Shared Neighborhood Hits	62
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

CCD1A_HUMAN
NC score	0.047365 (rank : 521)	θ value	1.06291 (rank : 185)
Query Neighborhood Hits	389	Target Neighborhood Hits	123	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P1N0, Q7Z435, Q86XV0, Q8NF89, Q9H603, Q9NXI1	Gene names	CC2D1A
Domain Architecture	No domain graphic available
Description	Coiled-coil and C2 domain-containing protein 1A (Five repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B- activating protein 023N).

RP3A_MOUSE
NC score	0.046934 (rank : 522)	θ value	0.813845 (rank : 182)
Query Neighborhood Hits	389	Target Neighborhood Hits	510	Shared Neighborhood Hits	82
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

TM16H_HUMAN
NC score	0.046245 (rank : 523)	θ value	5.27518 (rank : 323)
Query Neighborhood Hits	389	Target Neighborhood Hits	139	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

DAK_MOUSE
NC score	0.046056 (rank : 524)	θ value	0.47712 (rank : 141)
Query Neighborhood Hits	389	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC30	Gene names	Dak
Domain Architecture	No domain graphic available
Description	Dihydroxyacetone kinase (EC 2.7.1.29) (Glycerone kinase) (DHA kinase).

LDB3_MOUSE
NC score	0.045917 (rank : 525)	θ value	4.03905 (rank : 293)
Query Neighborhood Hits	389	Target Neighborhood Hits	510	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

SMOO_HUMAN
NC score	0.045697 (rank : 526)	θ value	8.99809 (rank : 381)
Query Neighborhood Hits	389	Target Neighborhood Hits	391	Shared Neighborhood Hits	58
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

ANR11_HUMAN
NC score	0.045298 (rank : 527)	θ value	4.03905 (rank : 283)
Query Neighborhood Hits	389	Target Neighborhood Hits	1289	Shared Neighborhood Hits	107
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

TACT_HUMAN
NC score	0.044443 (rank : 528)	θ value	1.06291 (rank : 200)
Query Neighborhood Hits	389	Target Neighborhood Hits	100	Shared Neighborhood Hits	10
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

RIN3_MOUSE
NC score	0.043889 (rank : 529)	θ value	3.0926 (rank : 274)
Query Neighborhood Hits	389	Target Neighborhood Hits	239	Shared Neighborhood Hits	41
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

WNK4_HUMAN
NC score	0.043678 (rank : 530)	θ value	0.0148317 (rank : 70)
Query Neighborhood Hits	389	Target Neighborhood Hits	1043	Shared Neighborhood Hits	79
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MEF2B_HUMAN
NC score	0.041851 (rank : 531)	θ value	1.81305 (rank : 231)
Query Neighborhood Hits	389	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

LDB3_HUMAN
NC score	0.041170 (rank : 532)	θ value	6.88961 (rank : 342)
Query Neighborhood Hits	389	Target Neighborhood Hits	497	Shared Neighborhood Hits	56
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

SPEG_MOUSE
NC score	0.041048 (rank : 533)	θ value	8.99809 (rank : 384)
Query Neighborhood Hits	389	Target Neighborhood Hits	1959	Shared Neighborhood Hits	159
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MILK2_HUMAN
NC score	0.041021 (rank : 534)	θ value	6.88961 (rank : 345)
Query Neighborhood Hits	389	Target Neighborhood Hits	457	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

DAAM2_MOUSE
NC score	0.040800 (rank : 535)	θ value	0.813845 (rank : 172)
Query Neighborhood Hits	389	Target Neighborhood Hits	371	Shared Neighborhood Hits	37
SwissProt Accessions	Q80U19, Q810J5	Gene names	Daam2, Kiaa0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

ZO1_HUMAN
NC score	0.039986 (rank : 536)	θ value	6.88961 (rank : 358)
Query Neighborhood Hits	389	Target Neighborhood Hits	474	Shared Neighborhood Hits	60
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

S23IP_HUMAN
NC score	0.039642 (rank : 537)	θ value	2.36792 (rank : 258)
Query Neighborhood Hits	389	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

ZO1_MOUSE
NC score	0.039323 (rank : 538)	θ value	1.81305 (rank : 241)
Query Neighborhood Hits	389	Target Neighborhood Hits	453	Shared Neighborhood Hits	47
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MYST3_HUMAN
NC score	0.039294 (rank : 539)	θ value	2.36792 (rank : 254)
Query Neighborhood Hits	389	Target Neighborhood Hits	772	Shared Neighborhood Hits	56
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

DAAM2_HUMAN
NC score	0.039245 (rank : 540)	θ value	4.03905 (rank : 285)
Query Neighborhood Hits	389	Target Neighborhood Hits	350	Shared Neighborhood Hits	34
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

PRGC2_MOUSE
NC score	0.038957 (rank : 541)	θ value	5.27518 (rank : 321)
Query Neighborhood Hits	389	Target Neighborhood Hits	225	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

ZO2_MOUSE
NC score	0.038288 (rank : 542)	θ value	3.0926 (rank : 282)
Query Neighborhood Hits	389	Target Neighborhood Hits	296	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

TACC2_HUMAN
NC score	0.037900 (rank : 543)	θ value	2.36792 (rank : 260)
Query Neighborhood Hits	389	Target Neighborhood Hits	856	Shared Neighborhood Hits	73
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

WBS14_HUMAN
NC score	0.037889 (rank : 544)	θ value	8.99809 (rank : 388)
Query Neighborhood Hits	389	Target Neighborhood Hits	273	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

ZO2_HUMAN
NC score	0.037831 (rank : 545)	θ value	1.81305 (rank : 242)
Query Neighborhood Hits	389	Target Neighborhood Hits	289	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

FETUA_HUMAN
NC score	0.036950 (rank : 546)	θ value	0.62314 (rank : 155)
Query Neighborhood Hits	389	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P02765, O14961, O14962, Q9P152	Gene names	AHSG, FETUA
Domain Architecture
Description	Alpha-2-HS-glycoprotein precursor (Fetuin-A) (Alpha-2-Z-globulin) (Ba- alpha-2-glycoprotein) [Contains: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B].

PP16A_MOUSE
NC score	0.036784 (rank : 547)	θ value	0.813845 (rank : 179)
Query Neighborhood Hits	389	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

SOX30_MOUSE
NC score	0.036360 (rank : 548)	θ value	4.03905 (rank : 305)
Query Neighborhood Hits	389	Target Neighborhood Hits	374	Shared Neighborhood Hits	73
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

DAK_HUMAN
NC score	0.036349 (rank : 549)	θ value	4.03905 (rank : 287)
Query Neighborhood Hits	389	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q3LXA3, Q53EQ9, Q9BVA7, Q9H895	Gene names	DAK
Domain Architecture	No domain graphic available
Description	Dihydroxyacetone kinase (EC 2.7.1.29) (Glycerone kinase) (DHA kinase).

FA61A_MOUSE
NC score	0.035488 (rank : 550)	θ value	1.38821 (rank : 205)
Query Neighborhood Hits	389	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K2F8, Q9CTG8	Gene names	Fam61a
Domain Architecture	No domain graphic available
Description	Protein FAM61A.

SPEG_HUMAN
NC score	0.034471 (rank : 551)	θ value	0.279714 (rank : 129)
Query Neighborhood Hits	389	Target Neighborhood Hits	1762	Shared Neighborhood Hits	130
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PCD15_HUMAN
NC score	0.034335 (rank : 552)	θ value	2.21117e-06 (rank : 12)
Query Neighborhood Hits	389	Target Neighborhood Hits	289	Shared Neighborhood Hits	24
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

MYST3_MOUSE
NC score	0.033903 (rank : 553)	θ value	4.03905 (rank : 297)
Query Neighborhood Hits	389	Target Neighborhood Hits	688	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

FOG1_MOUSE
NC score	0.033573 (rank : 554)	θ value	0.813845 (rank : 175)
Query Neighborhood Hits	389	Target Neighborhood Hits	1237	Shared Neighborhood Hits	96
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

JIP3_HUMAN
NC score	0.033547 (rank : 555)	θ value	8.99809 (rank : 373)
Query Neighborhood Hits	389	Target Neighborhood Hits	1039	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

TNKS1_HUMAN
NC score	0.033195 (rank : 556)	θ value	0.365318 (rank : 136)
Query Neighborhood Hits	389	Target Neighborhood Hits	477	Shared Neighborhood Hits	32
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

PCBP4_HUMAN
NC score	0.032936 (rank : 557)	θ value	4.03905 (rank : 301)
Query Neighborhood Hits	389	Target Neighborhood Hits	49	Shared Neighborhood Hits	7
SwissProt Accessions	P57723, Q96AH7	Gene names	PCBP4
Domain Architecture
Description	Poly(rC)-binding protein 4 (Alpha-CP4).

ETV5_MOUSE
NC score	0.032322 (rank : 558)	θ value	1.81305 (rank : 228)
Query Neighborhood Hits	389	Target Neighborhood Hits	328	Shared Neighborhood Hits	65
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

EP400_MOUSE
NC score	0.032068 (rank : 559)	θ value	6.88961 (rank : 335)
Query Neighborhood Hits	389	Target Neighborhood Hits	592	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

NFAC4_HUMAN
NC score	0.031922 (rank : 560)	θ value	1.81305 (rank : 233)
Query Neighborhood Hits	389	Target Neighborhood Hits	165	Shared Neighborhood Hits	31
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

EVL_HUMAN
NC score	0.031275 (rank : 561)	θ value	6.88961 (rank : 336)
Query Neighborhood Hits	389	Target Neighborhood Hits	260	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

WNK4_MOUSE
NC score	0.031099 (rank : 562)	θ value	8.99809 (rank : 389)
Query Neighborhood Hits	389	Target Neighborhood Hits	961	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

DAB2_MOUSE
NC score	0.030985 (rank : 563)	θ value	4.03905 (rank : 286)
Query Neighborhood Hits	389	Target Neighborhood Hits	163	Shared Neighborhood Hits	30
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

DCP1B_HUMAN
NC score	0.030573 (rank : 564)	θ value	4.03905 (rank : 288)
Query Neighborhood Hits	389	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IZD4, Q86XH9, Q96BP8, Q96MZ8	Gene names	DCP1B
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1B (EC 3.-.-.-).

DREB_HUMAN
NC score	0.030569 (rank : 565)	θ value	5.27518 (rank : 314)
Query Neighborhood Hits	389	Target Neighborhood Hits	450	Shared Neighborhood Hits	43
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

RANB9_HUMAN
NC score	0.030549 (rank : 566)	θ value	8.99809 (rank : 379)
Query Neighborhood Hits	389	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

CABL2_HUMAN
NC score	0.030329 (rank : 567)	θ value	1.38821 (rank : 204)
Query Neighborhood Hits	389	Target Neighborhood Hits	84	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CCDC4_HUMAN
NC score	0.030264 (rank : 568)	θ value	6.88961 (rank : 330)
Query Neighborhood Hits	389	Target Neighborhood Hits	104	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

FOG1_HUMAN
NC score	0.029734 (rank : 569)	θ value	0.0148317 (rank : 68)
Query Neighborhood Hits	389	Target Neighborhood Hits	981	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

DUS8_HUMAN
NC score	0.028315 (rank : 570)	θ value	0.813845 (rank : 173)
Query Neighborhood Hits	389	Target Neighborhood Hits	161	Shared Neighborhood Hits	27
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

T240L_HUMAN
NC score	0.027641 (rank : 571)	θ value	1.06291 (rank : 199)
Query Neighborhood Hits	389	Target Neighborhood Hits	132	Shared Neighborhood Hits	17
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

MINK1_MOUSE
NC score	0.027459 (rank : 572)	θ value	0.62314 (rank : 158)
Query Neighborhood Hits	389	Target Neighborhood Hits	1451	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

DTX1_MOUSE
NC score	0.027288 (rank : 573)	θ value	5.27518 (rank : 315)
Query Neighborhood Hits	389	Target Neighborhood Hits	99	Shared Neighborhood Hits	26
SwissProt Accessions	Q61010, Q3TER5, Q8C2H2, Q9ER09	Gene names	Dtx1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (mDTX1) (FXI-T1).

LIMD1_MOUSE
NC score	0.027077 (rank : 574)	θ value	1.06291 (rank : 189)
Query Neighborhood Hits	389	Target Neighborhood Hits	291	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

MINK1_HUMAN
NC score	0.027055 (rank : 575)	θ value	1.06291 (rank : 192)
Query Neighborhood Hits	389	Target Neighborhood Hits	1477	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

SOX17_MOUSE
NC score	0.026642 (rank : 576)	θ value	8.99809 (rank : 383)
Query Neighborhood Hits	389	Target Neighborhood Hits	223	Shared Neighborhood Hits	41
SwissProt Accessions	Q61473, Q61472, Q62248	Gene names	Sox17, Sox-17
Domain Architecture
Description	Transcription factor SOX-17.

GNAS1_HUMAN
NC score	0.025826 (rank : 577)	θ value	8.99809 (rank : 367)
Query Neighborhood Hits	389	Target Neighborhood Hits	278	Shared Neighborhood Hits	47
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

PAIP1_HUMAN
NC score	0.025258 (rank : 578)	θ value	4.03905 (rank : 300)
Query Neighborhood Hits	389	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

ZN703_HUMAN
NC score	0.025239 (rank : 579)	θ value	6.88961 (rank : 357)
Query Neighborhood Hits	389	Target Neighborhood Hits	154	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H7S9, Q5XG76	Gene names	ZNF703
Domain Architecture	No domain graphic available
Description	Zinc finger protein 703.

ESX1L_HUMAN
NC score	0.024514 (rank : 580)	θ value	4.03905 (rank : 290)
Query Neighborhood Hits	389	Target Neighborhood Hits	498	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

ACD_HUMAN
NC score	0.024465 (rank : 581)	θ value	8.99809 (rank : 359)
Query Neighborhood Hits	389	Target Neighborhood Hits	143	Shared Neighborhood Hits	27
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

CNTRB_HUMAN
NC score	0.024261 (rank : 582)	θ value	1.81305 (rank : 226)
Query Neighborhood Hits	389	Target Neighborhood Hits	690	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CBX2_HUMAN
NC score	0.024211 (rank : 583)	θ value	8.99809 (rank : 362)
Query Neighborhood Hits	389	Target Neighborhood Hits	264	Shared Neighborhood Hits	26
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

PP4R1_MOUSE
NC score	0.023655 (rank : 584)	θ value	1.38821 (rank : 215)
Query Neighborhood Hits	389	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

SNPC2_MOUSE
NC score	0.023447 (rank : 585)	θ value	8.99809 (rank : 382)
Query Neighborhood Hits	389	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	Q91XA5, Q3UK17, Q8CBS9	Gene names	Snapc2
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2).

DTX1_HUMAN
NC score	0.022936 (rank : 586)	θ value	6.88961 (rank : 333)
Query Neighborhood Hits	389	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q86Y01, O60630, Q9BS04	Gene names	DTX1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (hDTX1).

SETB1_MOUSE
NC score	0.022847 (rank : 587)	θ value	6.88961 (rank : 350)
Query Neighborhood Hits	389	Target Neighborhood Hits	150	Shared Neighborhood Hits	25
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

MAGD4_HUMAN
NC score	0.022750 (rank : 588)	θ value	4.03905 (rank : 295)
Query Neighborhood Hits	389	Target Neighborhood Hits	338	Shared Neighborhood Hits	50
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

SN1L2_HUMAN
NC score	0.022731 (rank : 589)	θ value	0.0563607 (rank : 84)
Query Neighborhood Hits	389	Target Neighborhood Hits	964	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

DVL2_MOUSE
NC score	0.022431 (rank : 590)	θ value	3.0926 (rank : 265)
Query Neighborhood Hits	389	Target Neighborhood Hits	233	Shared Neighborhood Hits	30
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

IL16_HUMAN
NC score	0.022297 (rank : 591)	θ value	2.36792 (rank : 251)
Query Neighborhood Hits	389	Target Neighborhood Hits	207	Shared Neighborhood Hits	22
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

NMDE3_MOUSE
NC score	0.021954 (rank : 592)	θ value	0.125558 (rank : 103)
Query Neighborhood Hits	389	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

SNX15_HUMAN
NC score	0.021623 (rank : 593)	θ value	4.03905 (rank : 304)
Query Neighborhood Hits	389	Target Neighborhood Hits	50	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRS6, Q9NRS5	Gene names	SNX15
Domain Architecture
Description	Sorting nexin-15.

TAOK2_HUMAN
NC score	0.021562 (rank : 594)	θ value	2.36792 (rank : 261)
Query Neighborhood Hits	389	Target Neighborhood Hits	1172	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

HPS4_HUMAN
NC score	0.020706 (rank : 595)	θ value	3.0926 (rank : 268)
Query Neighborhood Hits	389	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

HXB4_MOUSE
NC score	0.020699 (rank : 596)	θ value	0.0252991 (rank : 76)
Query Neighborhood Hits	389	Target Neighborhood Hits	375	Shared Neighborhood Hits	21
SwissProt Accessions	P10284, Q3UZB4, Q4VBG0	Gene names	Hoxb4, Hox-2.6, Hoxb-4
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2.6).

LSP1_MOUSE
NC score	0.019803 (rank : 597)	θ value	5.27518 (rank : 318)
Query Neighborhood Hits	389	Target Neighborhood Hits	125	Shared Neighborhood Hits	11
SwissProt Accessions	P19973, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65	Gene names	Lsp1, Pp52, S37, Wp34
Domain Architecture
Description	Lymphocyte-specific protein 1 (Protein pp52) (52 kDa phosphoprotein) (Lymphocyte-specific antigen WP34) (S37 protein).

ODPX_MOUSE
NC score	0.019218 (rank : 598)	θ value	2.36792 (rank : 255)
Query Neighborhood Hits	389	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

NEU1_MOUSE
NC score	0.018878 (rank : 599)	θ value	3.0926 (rank : 270)
Query Neighborhood Hits	389	Target Neighborhood Hits	64	Shared Neighborhood Hits	4
SwissProt Accessions	P35454	Gene names	Oxt
Domain Architecture
Description	Oxytocin-neurophysin 1 precursor (OT-NPI) [Contains: Oxytocin (Ocytocin); Neurophysin 1].

ATF5_MOUSE
NC score	0.018641 (rank : 600)	θ value	6.88961 (rank : 328)
Query Neighborhood Hits	389	Target Neighborhood Hits	62	Shared Neighborhood Hits	8
SwissProt Accessions	O70191, Q58E51, Q99NH6	Gene names	Atf5, Atfx, Nap1
Domain Architecture	No domain graphic available
Description	Cyclic AMP-dependent transcription factor ATF-5 (Activating transcription factor 5-alpha/beta) (Transcription factor ATFx) (Transcription factor-like protein ODA-10) (BZIP protein ATF7) (NRIF3- associated protein) (NAP1).

KBTBB_HUMAN
NC score	0.018460 (rank : 601)	θ value	1.38821 (rank : 209)
Query Neighborhood Hits	389	Target Neighborhood Hits	195	Shared Neighborhood Hits	17
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

K0174_MOUSE
NC score	0.018306 (rank : 602)	θ value	6.88961 (rank : 341)
Query Neighborhood Hits	389	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CX00, Q80U68	Gene names	Kiaa0174
Domain Architecture	No domain graphic available
Description	Protein KIAA0174.

HXB4_HUMAN
NC score	0.018208 (rank : 603)	θ value	0.365318 (rank : 131)
Query Neighborhood Hits	389	Target Neighborhood Hits	376	Shared Neighborhood Hits	23
SwissProt Accessions	P17483, Q9NTA0	Gene names	HOXB4, HOX2F
Domain Architecture
Description	Homeobox protein Hox-B4 (Hox-2F) (Hox-2.6).

MBRL_MOUSE
NC score	0.016835 (rank : 604)	θ value	5.27518 (rank : 319)
Query Neighborhood Hits	389	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CIV2, Q68EE1, Q6KAN7, Q7TS84, Q8CIV1, Q99K29	Gene names	ORF61
Domain Architecture	No domain graphic available
Description	Membralin.

DYN2_MOUSE
NC score	0.016371 (rank : 605)	θ value	2.36792 (rank : 248)
Query Neighborhood Hits	389	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

RAD9B_MOUSE
NC score	0.016316 (rank : 606)	θ value	4.03905 (rank : 302)
Query Neighborhood Hits	389	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q6WBX7	Gene names	Rad9b
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint control protein RAD9B homolog (RAD9 homolog B) (mRAD9B).

HSF4_HUMAN
NC score	0.016115 (rank : 607)	θ value	6.88961 (rank : 338)
Query Neighborhood Hits	389	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULV5, Q99472, Q9ULV6	Gene names	HSF4
Domain Architecture
Description	Heat shock factor protein 4 (HSF 4) (Heat shock transcription factor 4) (HSTF 4) (hHSF4).

HXB13_MOUSE
NC score	0.016058 (rank : 608)	θ value	0.62314 (rank : 156)
Query Neighborhood Hits	389	Target Neighborhood Hits	384	Shared Neighborhood Hits	18
SwissProt Accessions	P70321, Q80Y12	Gene names	Hoxb13
Domain Architecture
Description	Homeobox protein Hox-B13.

SSH1_HUMAN
NC score	0.015547 (rank : 609)	θ value	6.88961 (rank : 351)
Query Neighborhood Hits	389	Target Neighborhood Hits	164	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

HXD3_HUMAN
NC score	0.014087 (rank : 610)	θ value	4.03905 (rank : 291)
Query Neighborhood Hits	389	Target Neighborhood Hits	433	Shared Neighborhood Hits	27
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

VMD2_HUMAN
NC score	0.014075 (rank : 611)	θ value	3.0926 (rank : 277)
Query Neighborhood Hits	389	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	O76090, O75904, Q8IUR9, Q8IZ80	Gene names	VMD2
Domain Architecture
Description	Bestrophin-1 (Vitelliform macular dystrophy protein 2) (TU15B).

LITAF_MOUSE
NC score	0.013736 (rank : 612)	θ value	8.99809 (rank : 375)
Query Neighborhood Hits	389	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLJ0, Q9EQI0	Gene names	Litaf, N4wbp3, Tbx1
Domain Architecture	No domain graphic available
Description	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (LITAF-like protein) (NEDD4 WW domain-binding protein 3) (Estrogen-enhanced transcript protein) (mEET).

PGCB_HUMAN
NC score	0.013677 (rank : 613)	θ value	2.36792 (rank : 257)
Query Neighborhood Hits	389	Target Neighborhood Hits	478	Shared Neighborhood Hits	29
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

HXD3_MOUSE
NC score	0.013090 (rank : 614)	θ value	4.03905 (rank : 292)
Query Neighborhood Hits	389	Target Neighborhood Hits	435	Shared Neighborhood Hits	27
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

REC8L_HUMAN
NC score	0.012144 (rank : 615)	θ value	8.99809 (rank : 380)
Query Neighborhood Hits	389	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	O95072, Q8WUV8, Q9BTF2, Q9NVQ9	Gene names	REC8L1, REC8
Domain Architecture
Description	Meiotic recombination protein REC8-like 1 (Cohesin Rec8p).

DOK2_HUMAN
NC score	0.011308 (rank : 616)	θ value	6.88961 (rank : 331)
Query Neighborhood Hits	389	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

ZC3H5_HUMAN
NC score	0.010648 (rank : 617)	θ value	6.88961 (rank : 356)
Query Neighborhood Hits	389	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

JHD3D_HUMAN
NC score	0.010399 (rank : 618)	θ value	6.88961 (rank : 340)
Query Neighborhood Hits	389	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	Q6B0I6, Q9NT41, Q9NW76	Gene names	JMJD2D, JHDM3D
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 3D (EC 1.14.11.-) (Jumonji domain-containing protein 2D).

IDUA_MOUSE
NC score	0.010178 (rank : 619)	θ value	8.99809 (rank : 370)
Query Neighborhood Hits	389	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P48441	Gene names	Idua
Domain Architecture
Description	Alpha-L-iduronidase precursor (EC 3.2.1.76).

TRPV1_MOUSE
NC score	0.009532 (rank : 620)	θ value	4.03905 (rank : 308)
Query Neighborhood Hits	389	Target Neighborhood Hits	189	Shared Neighborhood Hits	6
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

ADA19_HUMAN
NC score	0.008904 (rank : 621)	θ value	1.38821 (rank : 202)
Query Neighborhood Hits	389	Target Neighborhood Hits	381	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

LAP4_HUMAN
NC score	0.008614 (rank : 622)	θ value	5.27518 (rank : 317)
Query Neighborhood Hits	389	Target Neighborhood Hits	608	Shared Neighborhood Hits	42
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

DUS2L_MOUSE
NC score	0.008310 (rank : 623)	θ value	8.99809 (rank : 364)
Query Neighborhood Hits	389	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D7B1, Q6PDX2	Gene names	Dus2l
Domain Architecture	No domain graphic available
Description	tRNA-dihydrouridine synthase 2-like (EC 1.-.-.-).

EMIL1_HUMAN
NC score	0.007927 (rank : 624)	θ value	6.88961 (rank : 334)
Query Neighborhood Hits	389	Target Neighborhood Hits	239	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6C2, Q96G58, Q9UG76	Gene names	EMILIN1, EMI
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

SEM4G_HUMAN
NC score	0.006910 (rank : 625)	θ value	1.38821 (rank : 219)
Query Neighborhood Hits	389	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NTN9, Q9HCF3	Gene names	SEMA4G, KIAA1619
Domain Architecture
Description	Semaphorin-4G precursor.

TBX18_MOUSE
NC score	0.005873 (rank : 626)	θ value	4.03905 (rank : 307)
Query Neighborhood Hits	389	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

PIWL2_HUMAN
NC score	0.005214 (rank : 627)	θ value	8.99809 (rank : 377)
Query Neighborhood Hits	389	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TC59, Q96SW6, Q9NW28	Gene names	PIWIL2, HILI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 2.

LTBP4_MOUSE
NC score	0.004472 (rank : 628)	θ value	4.03905 (rank : 294)
Query Neighborhood Hits	389	Target Neighborhood Hits	607	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

DSCL1_HUMAN
NC score	0.004318 (rank : 629)	θ value	6.88961 (rank : 332)
Query Neighborhood Hits	389	Target Neighborhood Hits	589	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

TRI16_HUMAN
NC score	0.003960 (rank : 630)	θ value	5.27518 (rank : 324)
Query Neighborhood Hits	389	Target Neighborhood Hits	231	Shared Neighborhood Hits	5
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

DPYL3_HUMAN
NC score	0.003196 (rank : 631)	θ value	8.99809 (rank : 363)
Query Neighborhood Hits	389	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q14195, Q93012	Gene names	DPYSL3, CRMP4, DRP3, ULIP
Domain Architecture
Description	Dihydropyrimidinase-related protein 3 (DRP-3) (Unc-33-like phosphoprotein) (ULIP protein) (Collapsin response mediator protein 4) (CRMP-4).

LRP5_MOUSE
NC score	0.001549 (rank : 632)	θ value	6.88961 (rank : 343)
Query Neighborhood Hits	389	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

IGHG3_HUMAN
NC score	0.000361 (rank : 633)	θ value	8.99809 (rank : 371)
Query Neighborhood Hits	389	Target Neighborhood Hits	234	Shared Neighborhood Hits	5
SwissProt Accessions	P01860	Gene names	IGHG3
Domain Architecture
Description	Ig gamma-3 chain C region (Heavy chain disease protein) (HDC).

NR1H2_MOUSE
NC score	0.000150 (rank : 634)	θ value	6.88961 (rank : 346)
Query Neighborhood Hits	389	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

JAG2_MOUSE
NC score	-0.002181 (rank : 635)	θ value	8.99809 (rank : 372)
Query Neighborhood Hits	389	Target Neighborhood Hits	504	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KLF13_MOUSE
NC score	-0.002775 (rank : 636)	θ value	2.36792 (rank : 252)
Query Neighborhood Hits	389	Target Neighborhood Hits	757	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJZ6, Q9ESX3, Q9JHF8	Gene names	Klf13, Bteb3, Fklf2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Erythroid transcription factor FKLF-2).

HIC1_MOUSE
NC score	-0.003123 (rank : 637)	θ value	1.81305 (rank : 229)
Query Neighborhood Hits	389	Target Neighborhood Hits	863	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

ZNF8_HUMAN
NC score	-0.007659 (rank : 638)	θ value	5.27518 (rank : 326)
Query Neighborhood Hits	389	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P17098, Q6PI99	Gene names	ZNF8
Domain Architecture	No domain graphic available
Description	Zinc finger protein 8 (Zinc finger protein HF.18).