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Network neighborhood for query Sequence : PREX1_HUMAN

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PREX1_HUMAN
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PREX1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_HUMAN
θ value	5.54529e-58 (rank : 2)	NC score	0.818221 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	242	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	3.36421e-55 (rank : 3)	NC score	0.844942 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	185	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	7.75577e-52 (rank : 4)	NC score	0.820045 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	74
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	1.01294e-51 (rank : 5)	NC score	0.819887 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	234	Shared Neighborhood Hits	74
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PKHG1_HUMAN
θ value	1.02001e-27 (rank : 6)	NC score	0.827750 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

INP4A_HUMAN
θ value	5.06226e-27 (rank : 7)	NC score	0.297485 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q96PE3, O15326, Q13187, Q53TD8, Q8TC02	Gene names	INPP4A
Domain Architecture	No domain graphic available
Description	Type I inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I).

INP4A_MOUSE
θ value	2.51237e-26 (rank : 8)	NC score	0.296478 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPW0, Q8CBJ8	Gene names	Inpp4a
Domain Architecture	No domain graphic available
Description	Type I inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I).

TIAM1_MOUSE
θ value	3.62785e-25 (rank : 9)	NC score	0.744504 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	205	Shared Neighborhood Hits	88
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
θ value	6.18819e-25 (rank : 10)	NC score	0.739069 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	94
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD3_HUMAN
θ value	1.05554e-24 (rank : 11)	NC score	0.736814 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	249	Shared Neighborhood Hits	82
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	1.37858e-24 (rank : 12)	NC score	0.758253 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	82
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
θ value	2.35151e-24 (rank : 13)	NC score	0.733524 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	151	Shared Neighborhood Hits	83
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
θ value	2.35151e-24 (rank : 14)	NC score	0.737396 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	219	Shared Neighborhood Hits	84
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_MOUSE
θ value	4.43474e-23 (rank : 15)	NC score	0.719579 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	163	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_MOUSE
θ value	1.6852e-22 (rank : 16)	NC score	0.735592 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	83
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_MOUSE
θ value	8.36355e-22 (rank : 17)	NC score	0.695139 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	387	Shared Neighborhood Hits	84
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	1.09232e-21 (rank : 18)	NC score	0.695196 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	367	Shared Neighborhood Hits	83
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

VAV2_HUMAN
θ value	1.86321e-21 (rank : 19)	NC score	0.569766 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	453	Shared Neighborhood Hits	74
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

DNMBP_MOUSE
θ value	4.15078e-21 (rank : 20)	NC score	0.594543 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	75
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_HUMAN
θ value	5.42112e-21 (rank : 21)	NC score	0.580298 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FARP2_MOUSE
θ value	7.0802e-21 (rank : 22)	NC score	0.533522 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	209	Shared Neighborhood Hits	80
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DUET_HUMAN
θ value	1.2077e-20 (rank : 23)	NC score	0.245744 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	1220	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

VAV2_MOUSE
θ value	1.2077e-20 (rank : 24)	NC score	0.572348 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	456	Shared Neighborhood Hits	74
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	1.2077e-20 (rank : 25)	NC score	0.556260 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	452	Shared Neighborhood Hits	74
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG7_HUMAN
θ value	1.5773e-20 (rank : 26)	NC score	0.619865 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	77
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FARP2_HUMAN
θ value	2.69047e-20 (rank : 27)	NC score	0.507474 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

INP4B_HUMAN
θ value	2.69047e-20 (rank : 28)	NC score	0.284156 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	O15327, Q6IN59, Q6PJB4	Gene names	INPP4B
Domain Architecture	No domain graphic available
Description	Type II inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II).

DNMBP_HUMAN
θ value	3.51386e-20 (rank : 29)	NC score	0.576951 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV_MOUSE
θ value	1.02238e-19 (rank : 30)	NC score	0.567323 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	430	Shared Neighborhood Hits	73
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG7_MOUSE
θ value	3.88503e-19 (rank : 31)	NC score	0.613108 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_MOUSE
θ value	6.62687e-19 (rank : 32)	NC score	0.564784 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	404	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
θ value	1.13037e-18 (rank : 33)	NC score	0.560440 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	398	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG6_MOUSE
θ value	1.47631e-18 (rank : 34)	NC score	0.557712 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ABR_HUMAN
θ value	1.92812e-18 (rank : 35)	NC score	0.442242 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG8_HUMAN
θ value	1.92812e-18 (rank : 36)	NC score	0.700470 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MCF2L_MOUSE
θ value	7.32683e-18 (rank : 37)	NC score	0.680316 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FGD6_MOUSE
θ value	9.56915e-18 (rank : 38)	NC score	0.635089 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	282	Shared Neighborhood Hits	77
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ITSN1_HUMAN
θ value	9.56915e-18 (rank : 39)	NC score	0.442394 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	1757	Shared Neighborhood Hits	87
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

FGD6_HUMAN
θ value	1.63225e-17 (rank : 40)	NC score	0.630271 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	237	Shared Neighborhood Hits	79
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ITSN1_MOUSE
θ value	2.13179e-17 (rank : 41)	NC score	0.441240 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	1669	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TRIO_HUMAN
θ value	3.63628e-17 (rank : 42)	NC score	0.239269 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	1580	Shared Neighborhood Hits	84
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ITSN2_HUMAN
θ value	6.20254e-17 (rank : 43)	NC score	0.478801 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	1173	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

BCR_HUMAN
θ value	1.38178e-16 (rank : 44)	NC score	0.438653 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

FARP1_HUMAN
θ value	1.38178e-16 (rank : 45)	NC score	0.462844 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	241	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

INP4B_MOUSE
θ value	1.80466e-16 (rank : 46)	NC score	0.275785 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P1Y8	Gene names	Inpp4b
Domain Architecture	No domain graphic available
Description	Type II inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II).

MCF2_HUMAN
θ value	1.80466e-16 (rank : 47)	NC score	0.720816 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	75
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ITSN2_MOUSE
θ value	3.07829e-16 (rank : 48)	NC score	0.451891 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	1371	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG3_MOUSE
θ value	5.25075e-16 (rank : 49)	NC score	0.703523 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
θ value	1.16975e-15 (rank : 50)	NC score	0.703693 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

SOS1_MOUSE
θ value	5.8054e-15 (rank : 51)	NC score	0.408991 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	281	Shared Neighborhood Hits	47
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHG8_MOUSE
θ value	9.90251e-15 (rank : 52)	NC score	0.674439 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	79	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ECT2_MOUSE
θ value	1.68911e-14 (rank : 53)	NC score	0.743637 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	75
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SOS1_HUMAN
θ value	1.68911e-14 (rank : 54)	NC score	0.422833 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	274	Shared Neighborhood Hits	47
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHGA_MOUSE
θ value	6.41864e-14 (rank : 55)	NC score	0.653618 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
θ value	8.38298e-14 (rank : 56)	NC score	0.652941 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	187	Shared Neighborhood Hits	67
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
θ value	8.38298e-14 (rank : 57)	NC score	0.729778 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGG_HUMAN
θ value	9.26847e-13 (rank : 58)	NC score	0.661398 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	129	Shared Neighborhood Hits	71
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	9.26847e-13 (rank : 59)	NC score	0.655875 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	152	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
θ value	1.2105e-12 (rank : 60)	NC score	0.640151 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	1.58096e-12 (rank : 61)	NC score	0.626334 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD5_MOUSE
θ value	2.0648e-12 (rank : 62)	NC score	0.491293 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	64
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

HAPIP_HUMAN
θ value	4.59992e-12 (rank : 63)	NC score	0.576106 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	76
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FGD5_HUMAN
θ value	7.84624e-12 (rank : 64)	NC score	0.511707 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	65
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHGB_HUMAN
θ value	2.98157e-11 (rank : 65)	NC score	0.593042 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	375	Shared Neighborhood Hits	105
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PKHG4_HUMAN
θ value	2.98157e-11 (rank : 66)	NC score	0.577584 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	200	Shared Neighborhood Hits	58
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RPGF4_MOUSE
θ value	1.9326e-10 (rank : 67)	NC score	0.200895 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	80	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
θ value	4.30538e-10 (rank : 68)	NC score	0.199784 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

SOS2_HUMAN
θ value	5.62301e-10 (rank : 69)	NC score	0.397852 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	193	Shared Neighborhood Hits	50
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ARHG2_HUMAN
θ value	9.59137e-10 (rank : 70)	NC score	0.534354 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	62
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	9.59137e-10 (rank : 71)	NC score	0.568999 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

OBSCN_HUMAN
θ value	9.59137e-10 (rank : 72)	NC score	0.117039 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	1931	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

GNRP_MOUSE
θ value	3.64472e-09 (rank : 73)	NC score	0.573249 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGC_MOUSE
θ value	4.76016e-09 (rank : 74)	NC score	0.551637 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	344	Shared Neighborhood Hits	100
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GP155_HUMAN
θ value	8.11959e-09 (rank : 75)	NC score	0.159394 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

GNRP_HUMAN
θ value	1.38499e-08 (rank : 76)	NC score	0.521983 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	239	Shared Neighborhood Hits	75
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHGC_HUMAN
θ value	3.08544e-08 (rank : 77)	NC score	0.557225 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	351	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
θ value	6.87365e-08 (rank : 78)	NC score	0.582169 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

RGNEF_MOUSE
θ value	6.87365e-08 (rank : 79)	NC score	0.474867 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	641	Shared Neighborhood Hits	68
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG1_MOUSE
θ value	8.97725e-08 (rank : 80)	NC score	0.527458 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGF_HUMAN
θ value	8.97725e-08 (rank : 81)	NC score	0.570392 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	65
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

RPGF3_MOUSE
θ value	1.99992e-07 (rank : 82)	NC score	0.178826 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF3_HUMAN
θ value	1.69304e-06 (rank : 83)	NC score	0.176752 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

ARHG5_HUMAN
θ value	4.1701e-05 (rank : 84)	NC score	0.633047 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	172	Shared Neighborhood Hits	73
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FYV1_HUMAN
θ value	0.000121331 (rank : 85)	NC score	0.157883 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0.000121331 (rank : 86)	NC score	0.155700 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

RPGF5_MOUSE
θ value	0.000121331 (rank : 87)	NC score	0.179406 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

LBC_HUMAN
θ value	0.00102713 (rank : 88)	NC score	0.534363 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

PKHF2_HUMAN
θ value	0.00175202 (rank : 89)	NC score	0.269489 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	0.00175202 (rank : 90)	NC score	0.268890 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

APBA1_HUMAN
θ value	0.0252991 (rank : 91)	NC score	0.066309 (rank : 251)
Query Neighborhood Hits	177	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

RGS7_HUMAN
θ value	0.0252991 (rank : 92)	NC score	0.051212 (rank : 305)
Query Neighborhood Hits	177	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_MOUSE
θ value	0.0252991 (rank : 93)	NC score	0.051004 (rank : 306)
Query Neighborhood Hits	177	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

PDZD3_HUMAN
θ value	0.0330416 (rank : 94)	NC score	0.082515 (rank : 198)
Query Neighborhood Hits	177	Target Neighborhood Hits	180	Shared Neighborhood Hits	40
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PLEK2_MOUSE
θ value	0.0563607 (rank : 95)	NC score	0.070402 (rank : 236)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

WHRN_MOUSE
θ value	0.0736092 (rank : 96)	NC score	0.067247 (rank : 244)
Query Neighborhood Hits	177	Target Neighborhood Hits	412	Shared Neighborhood Hits	48
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

DVL2_HUMAN
θ value	0.0961366 (rank : 97)	NC score	0.058722 (rank : 282)
Query Neighborhood Hits	177	Target Neighborhood Hits	223	Shared Neighborhood Hits	36
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	0.0961366 (rank : 98)	NC score	0.059982 (rank : 276)
Query Neighborhood Hits	177	Target Neighborhood Hits	233	Shared Neighborhood Hits	38
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

PDZD3_MOUSE
θ value	0.0961366 (rank : 99)	NC score	0.074506 (rank : 226)
Query Neighborhood Hits	177	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

RGS6_HUMAN
θ value	0.0961366 (rank : 100)	NC score	0.049673 (rank : 308)
Query Neighborhood Hits	177	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS6_MOUSE
θ value	0.0961366 (rank : 101)	NC score	0.048161 (rank : 309)
Query Neighborhood Hits	177	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

APBA3_HUMAN
θ value	0.125558 (rank : 102)	NC score	0.069546 (rank : 239)
Query Neighborhood Hits	177	Target Neighborhood Hits	201	Shared Neighborhood Hits	40
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MAST1_HUMAN
θ value	0.163984 (rank : 103)	NC score	0.015845 (rank : 335)
Query Neighborhood Hits	177	Target Neighborhood Hits	1146	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

WHRN_HUMAN
θ value	0.163984 (rank : 104)	NC score	0.067683 (rank : 243)
Query Neighborhood Hits	177	Target Neighborhood Hits	325	Shared Neighborhood Hits	49
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

NHERF_HUMAN
θ value	0.21417 (rank : 105)	NC score	0.065730 (rank : 253)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	37
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD1_MOUSE
θ value	0.21417 (rank : 106)	NC score	0.071206 (rank : 233)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PLEK2_HUMAN
θ value	0.21417 (rank : 107)	NC score	0.070072 (rank : 237)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

DVL3_MOUSE
θ value	0.279714 (rank : 108)	NC score	0.062266 (rank : 262)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

MAST1_MOUSE
θ value	0.279714 (rank : 109)	NC score	0.015002 (rank : 336)
Query Neighborhood Hits	177	Target Neighborhood Hits	1123	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PKHF1_HUMAN
θ value	0.279714 (rank : 110)	NC score	0.252941 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

CYH1_HUMAN
θ value	0.365318 (rank : 111)	NC score	0.032235 (rank : 320)
Query Neighborhood Hits	177	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

PLEK_HUMAN
θ value	0.365318 (rank : 112)	NC score	0.076965 (rank : 217)
Query Neighborhood Hits	177	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

SDCB1_HUMAN
θ value	0.365318 (rank : 113)	NC score	0.062702 (rank : 260)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.365318 (rank : 114)	NC score	0.061729 (rank : 265)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

TX1B3_HUMAN
θ value	0.365318 (rank : 115)	NC score	0.061802 (rank : 264)
Query Neighborhood Hits	177	Target Neighborhood Hits	161	Shared Neighborhood Hits	43
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.365318 (rank : 116)	NC score	0.061847 (rank : 263)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

DVL1L_HUMAN
θ value	0.47712 (rank : 117)	NC score	0.058149 (rank : 285)
Query Neighborhood Hits	177	Target Neighborhood Hits	146	Shared Neighborhood Hits	34
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	0.47712 (rank : 118)	NC score	0.057934 (rank : 288)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	35
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_HUMAN
θ value	0.47712 (rank : 119)	NC score	0.063136 (rank : 259)
Query Neighborhood Hits	177	Target Neighborhood Hits	194	Shared Neighborhood Hits	40
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PKHF1_MOUSE
θ value	0.47712 (rank : 120)	NC score	0.251027 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	80	Shared Neighborhood Hits	24
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

MY18A_HUMAN
θ value	0.62314 (rank : 121)	NC score	0.022692 (rank : 323)
Query Neighborhood Hits	177	Target Neighborhood Hits	1929	Shared Neighborhood Hits	63
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	0.62314 (rank : 122)	NC score	0.021337 (rank : 324)
Query Neighborhood Hits	177	Target Neighborhood Hits	1989	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RPGF2_HUMAN
θ value	0.62314 (rank : 123)	NC score	0.148020 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	242	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

APBA2_HUMAN
θ value	0.813845 (rank : 124)	NC score	0.061329 (rank : 266)
Query Neighborhood Hits	177	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.813845 (rank : 125)	NC score	0.062351 (rank : 261)
Query Neighborhood Hits	177	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DVL1_MOUSE
θ value	0.813845 (rank : 126)	NC score	0.058023 (rank : 286)
Query Neighborhood Hits	177	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

NHERF_MOUSE
θ value	0.813845 (rank : 127)	NC score	0.061178 (rank : 267)
Query Neighborhood Hits	177	Target Neighborhood Hits	195	Shared Neighborhood Hits	38
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

RAI1_MOUSE
θ value	0.813845 (rank : 128)	NC score	0.018985 (rank : 329)
Query Neighborhood Hits	177	Target Neighborhood Hits	344	Shared Neighborhood Hits	4
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RGS11_HUMAN
θ value	0.813845 (rank : 129)	NC score	0.042264 (rank : 316)
Query Neighborhood Hits	177	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	O94810, O75883	Gene names	RGS11
Domain Architecture
Description	Regulator of G-protein signaling 11 (RGS11).

APBA3_MOUSE
θ value	1.06291 (rank : 130)	NC score	0.059378 (rank : 278)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	32
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MPP3_HUMAN
θ value	1.06291 (rank : 131)	NC score	0.030344 (rank : 322)
Query Neighborhood Hits	177	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PLEK_MOUSE
θ value	1.06291 (rank : 132)	NC score	0.074765 (rank : 224)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RHPN1_HUMAN
θ value	1.06291 (rank : 133)	NC score	0.046260 (rank : 311)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

YTDC1_HUMAN
θ value	1.06291 (rank : 134)	NC score	0.016286 (rank : 333)
Query Neighborhood Hits	177	Target Neighborhood Hits	458	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

PDZD1_HUMAN
θ value	1.38821 (rank : 135)	NC score	0.064009 (rank : 257)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

RGS9_HUMAN
θ value	1.38821 (rank : 136)	NC score	0.038182 (rank : 319)
Query Neighborhood Hits	177	Target Neighborhood Hits	64	Shared Neighborhood Hits	16
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

RPGF6_HUMAN
θ value	1.38821 (rank : 137)	NC score	0.140173 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

AP1G2_HUMAN
θ value	1.81305 (rank : 138)	NC score	0.008398 (rank : 344)
Query Neighborhood Hits	177	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

HIC1_MOUSE
θ value	1.81305 (rank : 139)	NC score	-0.006139 (rank : 355)
Query Neighborhood Hits	177	Target Neighborhood Hits	863	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

MPP3_MOUSE
θ value	1.81305 (rank : 140)	NC score	0.030413 (rank : 321)
Query Neighborhood Hits	177	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

PUR8_HUMAN
θ value	1.81305 (rank : 141)	NC score	0.018005 (rank : 330)
Query Neighborhood Hits	177	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P30566, O75495, Q5TI34	Gene names	ADSL, AMPS
Domain Architecture
Description	Adenylosuccinate lyase (EC 4.3.2.2) (Adenylosuccinase) (ASL) (ASASE).

RHPN1_MOUSE
θ value	1.81305 (rank : 142)	NC score	0.047692 (rank : 310)
Query Neighborhood Hits	177	Target Neighborhood Hits	154	Shared Neighborhood Hits	31
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SHBG_MOUSE
θ value	1.81305 (rank : 143)	NC score	0.014901 (rank : 337)
Query Neighborhood Hits	177	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P97497	Gene names	Shbg
Domain Architecture
Description	Sex hormone-binding globulin precursor (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP).

LMO7_HUMAN
θ value	2.36792 (rank : 144)	NC score	0.094810 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	507	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

PARD3_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.045384 (rank : 312)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

DDB1_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.013851 (rank : 339)
Query Neighborhood Hits	177	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q16531, O15176, Q13289, Q58F96	Gene names	DDB1
Domain Architecture
Description	DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor) (DDB p127 subunit) (DDBa) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (Xeroderma pigmentosum group E- complementing protein) (XPCe) (XPE-binding factor) (XPE-BF) (X- associated protein 1) (XAP-1).

DEPD5_MOUSE
θ value	4.03905 (rank : 147)	NC score	0.021221 (rank : 325)
Query Neighborhood Hits	177	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

K0090_MOUSE
θ value	4.03905 (rank : 148)	NC score	0.011551 (rank : 343)
Query Neighborhood Hits	177	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C7X2, Q3TCG4, Q6ZQJ4, Q8K3W8	Gene names	Kiaa0090
Domain Architecture	No domain graphic available
Description	Protein KIAA0090 precursor.

OSBL9_HUMAN
θ value	4.03905 (rank : 149)	NC score	0.044729 (rank : 313)
Query Neighborhood Hits	177	Target Neighborhood Hits	138	Shared Neighborhood Hits	25
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PARD3_MOUSE
θ value	4.03905 (rank : 150)	NC score	0.044173 (rank : 315)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	48
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

RAI1_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.014482 (rank : 338)
Query Neighborhood Hits	177	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SGOL1_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.013586 (rank : 340)
Query Neighborhood Hits	177	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CXH7, Q3U4K4, Q588H1, Q8BKW2	Gene names	Sgol1, Sgo1
Domain Architecture	No domain graphic available
Description	Shugoshin-like 1.

SHAN1_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.098406 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	1041	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EEA1_MOUSE
θ value	5.27518 (rank : 154)	NC score	0.066494 (rank : 249)
Query Neighborhood Hits	177	Target Neighborhood Hits	1637	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

GRIP1_HUMAN
θ value	5.27518 (rank : 155)	NC score	0.038896 (rank : 318)
Query Neighborhood Hits	177	Target Neighborhood Hits	231	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	5.27518 (rank : 156)	NC score	0.039610 (rank : 317)
Query Neighborhood Hits	177	Target Neighborhood Hits	241	Shared Neighborhood Hits	47
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

P3C2A_HUMAN
θ value	5.27518 (rank : 157)	NC score	0.001924 (rank : 352)
Query Neighborhood Hits	177	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PDZD7_HUMAN
θ value	5.27518 (rank : 158)	NC score	0.058892 (rank : 281)
Query Neighborhood Hits	177	Target Neighborhood Hits	181	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

RS17_HUMAN
θ value	5.27518 (rank : 159)	NC score	0.019775 (rank : 327)
Query Neighborhood Hits	177	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P08708	Gene names	RPS17
Domain Architecture
Description	40S ribosomal protein S17.

RS17_MOUSE
θ value	5.27518 (rank : 160)	NC score	0.019785 (rank : 326)
Query Neighborhood Hits	177	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P63276, P06584	Gene names	Rps17
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S17.

SL9A5_HUMAN
θ value	5.27518 (rank : 161)	NC score	0.006019 (rank : 348)
Query Neighborhood Hits	177	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q14940, Q9Y626	Gene names	SLC9A5, NHE5
Domain Architecture
Description	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5).

CEAM7_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.002994 (rank : 350)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

HNRPC_MOUSE
θ value	6.88961 (rank : 163)	NC score	0.005213 (rank : 349)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z204, Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83	Gene names	Hnrpc, Hnrnpc
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

LRRF2_MOUSE
θ value	6.88961 (rank : 164)	NC score	0.012025 (rank : 342)
Query Neighborhood Hits	177	Target Neighborhood Hits	556	Shared Neighborhood Hits	11
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

PRDM5_MOUSE
θ value	6.88961 (rank : 165)	NC score	-0.007931 (rank : 356)
Query Neighborhood Hits	177	Target Neighborhood Hits	774	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CXE0	Gene names	Prdm5
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 5 (PR domain-containing protein 5).

SDCB2_MOUSE
θ value	6.88961 (rank : 166)	NC score	0.044446 (rank : 314)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

CAR10_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.017629 (rank : 331)
Query Neighborhood Hits	177	Target Neighborhood Hits	569	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CAR10_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.012975 (rank : 341)
Query Neighborhood Hits	177	Target Neighborhood Hits	407	Shared Neighborhood Hits	15
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

CCD41_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.016658 (rank : 332)
Query Neighborhood Hits	177	Target Neighborhood Hits	1139	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

HUWE1_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.006657 (rank : 346)
Query Neighborhood Hits	177	Target Neighborhood Hits	443	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	8.99809 (rank : 171)	NC score	0.007655 (rank : 345)
Query Neighborhood Hits	177	Target Neighborhood Hits	406	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

IFIH1_HUMAN
θ value	8.99809 (rank : 172)	NC score	0.002918 (rank : 351)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LAMB1_MOUSE
θ value	8.99809 (rank : 173)	NC score	-0.002170 (rank : 354)
Query Neighborhood Hits	177	Target Neighborhood Hits	919	Shared Neighborhood Hits	11
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LEO1_HUMAN
θ value	8.99809 (rank : 174)	NC score	0.000881 (rank : 353)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

SARM1_MOUSE
θ value	8.99809 (rank : 175)	NC score	0.006195 (rank : 347)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SYCP1_MOUSE
θ value	8.99809 (rank : 176)	NC score	0.019357 (rank : 328)
Query Neighborhood Hits	177	Target Neighborhood Hits	1456	Shared Neighborhood Hits	29
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TNNT2_HUMAN
θ value	8.99809 (rank : 177)	NC score	0.016243 (rank : 334)
Query Neighborhood Hits	177	Target Neighborhood Hits	433	Shared Neighborhood Hits	14
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

ABI1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.108658 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.117218 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.121210 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.121480 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.101889 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.098599 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.104516 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.101246 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	496	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALS2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.066502 (rank : 248)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.076565 (rank : 218)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ANM2_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.094362 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	19
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.086370 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ASPP1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.065286 (rank : 255)
Query Neighborhood Hits	177	Target Neighborhood Hits	956	Shared Neighborhood Hits	27
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.068472 (rank : 242)
Query Neighborhood Hits	177	Target Neighborhood Hits	1244	Shared Neighborhood Hits	34
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAIP2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.063864 (rank : 258)
Query Neighborhood Hits	177	Target Neighborhood Hits	192	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.065302 (rank : 254)
Query Neighborhood Hits	177	Target Neighborhood Hits	185	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.084409 (rank : 193)
Query Neighborhood Hits	177	Target Neighborhood Hits	554	Shared Neighborhood Hits	26
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.086327 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.111439 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.085853 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.083019 (rank : 197)
Query Neighborhood Hits	177	Target Neighborhood Hits	259	Shared Neighborhood Hits	21
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.078892 (rank : 207)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.180377 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.177190 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CNN1_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.060864 (rank : 271)
Query Neighborhood Hits	177	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.060734 (rank : 272)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN2_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.056216 (rank : 293)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN2_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.059987 (rank : 275)
Query Neighborhood Hits	177	Target Neighborhood Hits	39	Shared Neighborhood Hits	10
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN3_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.057269 (rank : 291)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.057399 (rank : 290)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CRKL_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.121237 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.118411 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.113804 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.116946 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.085672 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.104475 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	244	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.101630 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	306	Shared Neighborhood Hits	24
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.059294 (rank : 279)
Query Neighborhood Hits	177	Target Neighborhood Hits	592	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.066624 (rank : 247)
Query Neighborhood Hits	177	Target Neighborhood Hits	599	Shared Neighborhood Hits	30
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.066881 (rank : 245)
Query Neighborhood Hits	177	Target Neighborhood Hits	625	Shared Neighborhood Hits	29
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EEA1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.059830 (rank : 277)
Query Neighborhood Hits	177	Target Neighborhood Hits	1796	Shared Neighborhood Hits	46
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EFS_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.069541 (rank : 240)
Query Neighborhood Hits	177	Target Neighborhood Hits	348	Shared Neighborhood Hits	20
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.074889 (rank : 222)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	23
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.078900 (rank : 206)
Query Neighborhood Hits	177	Target Neighborhood Hits	432	Shared Neighborhood Hits	26
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYCO1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.056114 (rank : 294)
Query Neighborhood Hits	177	Target Neighborhood Hits	1149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.053954 (rank : 301)
Query Neighborhood Hits	177	Target Neighborhood Hits	1059	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GNDS_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.070958 (rank : 234)
Query Neighborhood Hits	177	Target Neighborhood Hits	201	Shared Neighborhood Hits	14
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.072150 (rank : 230)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GRAP2_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.131942 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	304	Shared Neighborhood Hits	22
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.132054 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.152658 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.150832 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	309	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.138643 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.138625 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.133610 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.126158 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	358	Shared Neighborhood Hits	22
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.128091 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.108826 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	517	Shared Neighborhood Hits	25
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.109000 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	589	Shared Neighborhood Hits	25
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.066835 (rank : 246)
Query Neighborhood Hits	177	Target Neighborhood Hits	688	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.069611 (rank : 238)
Query Neighborhood Hits	177	Target Neighborhood Hits	1024	Shared Neighborhood Hits	32
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.086127 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.083810 (rank : 194)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MIA_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.060346 (rank : 274)
Query Neighborhood Hits	177	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.060968 (rank : 269)
Query Neighborhood Hits	177	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MTMR3_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.071239 (rank : 232)
Query Neighborhood Hits	177	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MYO1E_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.057506 (rank : 289)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.058001 (rank : 287)
Query Neighborhood Hits	177	Target Neighborhood Hits	275	Shared Neighborhood Hits	26
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.059217 (rank : 280)
Query Neighborhood Hits	177	Target Neighborhood Hits	262	Shared Neighborhood Hits	28
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.196460 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.181162 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.161103 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	229	Shared Neighborhood Hits	26
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.158351 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.156588 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.149036 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	29
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.142977 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	27
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.080098 (rank : 203)
Query Neighborhood Hits	177	Target Neighborhood Hits	457	Shared Neighborhood Hits	26
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.072534 (rank : 229)
Query Neighborhood Hits	177	Target Neighborhood Hits	420	Shared Neighborhood Hits	27
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NHRF2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.056866 (rank : 292)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.054730 (rank : 298)
Query Neighborhood Hits	177	Target Neighborhood Hits	194	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NOXO1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.084527 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.087234 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.073889 (rank : 227)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	26
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.099625 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.105181 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	466	Shared Neighborhood Hits	22
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.104850 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.064034 (rank : 256)
Query Neighborhood Hits	177	Target Neighborhood Hits	479	Shared Neighborhood Hits	18
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.060977 (rank : 268)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	17
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.060612 (rank : 273)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.058581 (rank : 284)
Query Neighborhood Hits	177	Target Neighborhood Hits	519	Shared Neighborhood Hits	20
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.078519 (rank : 209)
Query Neighborhood Hits	177	Target Neighborhood Hits	320	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.077519 (rank : 213)
Query Neighborhood Hits	177	Target Neighborhood Hits	283	Shared Neighborhood Hits	22
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.088326 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	339	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.089017 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	382	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.079279 (rank : 205)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.080370 (rank : 202)
Query Neighborhood Hits	177	Target Neighborhood Hits	380	Shared Neighborhood Hits	22
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.087852 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.091807 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA4_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.051440 (rank : 304)
Query Neighborhood Hits	177	Target Neighborhood Hits	283	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.054693 (rank : 299)
Query Neighborhood Hits	177	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.055033 (rank : 297)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.083269 (rank : 195)
Query Neighborhood Hits	177	Target Neighborhood Hits	556	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.081345 (rank : 201)
Query Neighborhood Hits	177	Target Neighborhood Hits	591	Shared Neighborhood Hits	26
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLCG1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.109014 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	21
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.110022 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.094964 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	280	Shared Neighborhood Hits	17
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.117919 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	29
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.112288 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	377	Shared Neighborhood Hits	28
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.113631 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.107901 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	22
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.054283 (rank : 300)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.055306 (rank : 296)
Query Neighborhood Hits	177	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.055450 (rank : 295)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGDSR_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.068681 (rank : 241)
Query Neighborhood Hits	177	Target Neighborhood Hits	63	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RGL1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.091384 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.083261 (rank : 196)
Query Neighborhood Hits	177	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.073872 (rank : 228)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.071622 (rank : 231)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RHG04_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.099434 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.074767 (rank : 223)
Query Neighborhood Hits	177	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.078091 (rank : 211)
Query Neighborhood Hits	177	Target Neighborhood Hits	263	Shared Neighborhood Hits	20
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.077135 (rank : 215)
Query Neighborhood Hits	177	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RPGF1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.132664 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	262	Shared Neighborhood Hits	16
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF5_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.152081 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RUFY1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.076306 (rank : 220)
Query Neighborhood Hits	177	Target Neighborhood Hits	848	Shared Neighborhood Hits	34
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.077128 (rank : 216)
Query Neighborhood Hits	177	Target Neighborhood Hits	765	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.070469 (rank : 235)
Query Neighborhood Hits	177	Target Neighborhood Hits	1208	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.078552 (rank : 208)
Query Neighborhood Hits	177	Target Neighborhood Hits	820	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.119489 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.115399 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	291	Shared Neighborhood Hits	24
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.115862 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.113159 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.118695 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.120959 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.190219 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.178122 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.123201 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SNX18_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.058696 (rank : 283)
Query Neighborhood Hits	177	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.060898 (rank : 270)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.052121 (rank : 303)
Query Neighborhood Hits	177	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SPTA1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.076350 (rank : 219)
Query Neighborhood Hits	177	Target Neighborhood Hits	748	Shared Neighborhood Hits	36
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.079291 (rank : 204)
Query Neighborhood Hits	177	Target Neighborhood Hits	675	Shared Neighborhood Hits	30
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.081359 (rank : 200)
Query Neighborhood Hits	177	Target Neighborhood Hits	888	Shared Neighborhood Hits	37
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.160149 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.158428 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.127459 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.125556 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	292	Shared Neighborhood Hits	25
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.081906 (rank : 199)
Query Neighborhood Hits	177	Target Neighborhood Hits	390	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.077186 (rank : 214)
Query Neighborhood Hits	177	Target Neighborhood Hits	331	Shared Neighborhood Hits	25
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.078324 (rank : 210)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	25
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.134230 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.135204 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.152738 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.147268 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.134083 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.132547 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.125217 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.125701 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.095184 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.102822 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

USH1C_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.052297 (rank : 302)
Query Neighborhood Hits	177	Target Neighborhood Hits	327	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.050411 (rank : 307)
Query Neighborhood Hits	177	Target Neighborhood Hits	557	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

VINEX_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.150720 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	270	Shared Neighborhood Hits	26
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.151295 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDFY1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.078080 (rank : 212)
Query Neighborhood Hits	177	Target Neighborhood Hits	305	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.065922 (rank : 252)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	19
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.066430 (rank : 250)
Query Neighborhood Hits	177	Target Neighborhood Hits	337	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY3_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.075465 (rank : 221)
Query Neighborhood Hits	177	Target Neighborhood Hits	348	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.074706 (rank : 225)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	20
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ZFY16_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.138099 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.141380 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	108	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.093705 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	21
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.087698 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	143	Shared Neighborhood Hits	22
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.141095 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.143447 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.153480 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	152	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.093642 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.092047 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	153	Shared Neighborhood Hits	19
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.148164 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

PREX1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_MOUSE
NC score	0.844942 (rank : 2)	θ value	3.36421e-55 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	185	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.827750 (rank : 3)	θ value	1.02001e-27 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG9_HUMAN
NC score	0.820045 (rank : 4)	θ value	7.75577e-52 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	74
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.819887 (rank : 5)	θ value	1.01294e-51 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	234	Shared Neighborhood Hits	74
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_HUMAN
NC score	0.818221 (rank : 6)	θ value	5.54529e-58 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	242	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_MOUSE
NC score	0.758253 (rank : 7)	θ value	1.37858e-24 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	82
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TIAM1_MOUSE
NC score	0.744504 (rank : 8)	θ value	3.62785e-25 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	205	Shared Neighborhood Hits	88
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ECT2_MOUSE
NC score	0.743637 (rank : 9)	θ value	1.68911e-14 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	75
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

TIAM1_HUMAN
NC score	0.739069 (rank : 10)	θ value	6.18819e-25 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	94
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD4_HUMAN
NC score	0.737396 (rank : 11)	θ value	2.35151e-24 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	219	Shared Neighborhood Hits	84
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD3_HUMAN
NC score	0.736814 (rank : 12)	θ value	1.05554e-24 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	249	Shared Neighborhood Hits	82
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_MOUSE
NC score	0.735592 (rank : 13)	θ value	1.6852e-22 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	83
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_HUMAN
NC score	0.733524 (rank : 14)	θ value	2.35151e-24 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	151	Shared Neighborhood Hits	83
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ECT2_HUMAN
NC score	0.729778 (rank : 15)	θ value	8.38298e-14 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

MCF2_HUMAN
NC score	0.720816 (rank : 16)	θ value	1.80466e-16 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	75
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

FGD2_MOUSE
NC score	0.719579 (rank : 17)	θ value	4.43474e-23 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	163	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG3_HUMAN
NC score	0.703693 (rank : 18)	θ value	1.16975e-15 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.703523 (rank : 19)	θ value	5.25075e-16 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
NC score	0.700470 (rank : 20)	θ value	1.92812e-18 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD1_HUMAN
NC score	0.695196 (rank : 21)	θ value	1.09232e-21 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	367	Shared Neighborhood Hits	83
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.695139 (rank : 22)	θ value	8.36355e-22 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	387	Shared Neighborhood Hits	84
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MCF2L_MOUSE
NC score	0.680316 (rank : 23)	θ value	7.32683e-18 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG8_MOUSE
NC score	0.674439 (rank : 24)	θ value	9.90251e-15 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	79	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
NC score	0.661398 (rank : 25)	θ value	9.26847e-13 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	129	Shared Neighborhood Hits	71
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.655875 (rank : 26)	θ value	9.26847e-13 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	152	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGA_MOUSE
NC score	0.653618 (rank : 27)	θ value	6.41864e-14 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.652941 (rank : 28)	θ value	8.38298e-14 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	187	Shared Neighborhood Hits	67
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

NGEF_HUMAN
NC score	0.640151 (rank : 29)	θ value	1.2105e-12 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD6_MOUSE
NC score	0.635089 (rank : 30)	θ value	9.56915e-18 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	282	Shared Neighborhood Hits	77
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ARHG5_HUMAN
NC score	0.633047 (rank : 31)	θ value	4.1701e-05 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	172	Shared Neighborhood Hits	73
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD6_HUMAN
NC score	0.630271 (rank : 32)	θ value	1.63225e-17 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	237	Shared Neighborhood Hits	79
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

NGEF_MOUSE
NC score	0.626334 (rank : 33)	θ value	1.58096e-12 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG7_HUMAN
NC score	0.619865 (rank : 34)	θ value	1.5773e-20 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	77
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.613108 (rank : 35)	θ value	3.88503e-19 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DNMBP_MOUSE
NC score	0.594543 (rank : 36)	θ value	4.15078e-21 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	75
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGB_HUMAN
NC score	0.593042 (rank : 37)	θ value	2.98157e-11 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	375	Shared Neighborhood Hits	105
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG1_HUMAN
NC score	0.582169 (rank : 38)	θ value	6.87365e-08 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG6_HUMAN
NC score	0.580298 (rank : 39)	θ value	5.42112e-21 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PKHG4_HUMAN
NC score	0.577584 (rank : 40)	θ value	2.98157e-11 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	200	Shared Neighborhood Hits	58
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

DNMBP_HUMAN
NC score	0.576951 (rank : 41)	θ value	3.51386e-20 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HAPIP_HUMAN
NC score	0.576106 (rank : 42)	θ value	4.59992e-12 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	76
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

GNRP_MOUSE
NC score	0.573249 (rank : 43)	θ value	3.64472e-09 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

VAV2_MOUSE
NC score	0.572348 (rank : 44)	θ value	1.2077e-20 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	456	Shared Neighborhood Hits	74
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHGF_HUMAN
NC score	0.570392 (rank : 45)	θ value	8.97725e-08 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	65
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

VAV2_HUMAN
NC score	0.569766 (rank : 46)	θ value	1.86321e-21 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	453	Shared Neighborhood Hits	74
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG2_MOUSE
NC score	0.568999 (rank : 47)	θ value	9.59137e-10 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

VAV_MOUSE
NC score	0.567323 (rank : 48)	θ value	1.02238e-19 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	430	Shared Neighborhood Hits	73
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV3_MOUSE
NC score	0.564784 (rank : 49)	θ value	6.62687e-19 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	404	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.560440 (rank : 50)	θ value	1.13037e-18 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	398	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG6_MOUSE
NC score	0.557712 (rank : 51)	θ value	1.47631e-18 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGC_HUMAN
NC score	0.557225 (rank : 52)	θ value	3.08544e-08 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	351	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

VAV_HUMAN
NC score	0.556260 (rank : 53)	θ value	1.2077e-20 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	452	Shared Neighborhood Hits	74
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGC_MOUSE
NC score	0.551637 (rank : 54)	θ value	4.76016e-09 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	344	Shared Neighborhood Hits	100
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LBC_HUMAN
NC score	0.534363 (rank : 55)	θ value	0.00102713 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_HUMAN
NC score	0.534354 (rank : 56)	θ value	9.59137e-10 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	142	Shared Neighborhood Hits	62
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

FARP2_MOUSE
NC score	0.533522 (rank : 57)	θ value	7.0802e-21 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	209	Shared Neighborhood Hits	80
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG1_MOUSE
NC score	0.527458 (rank : 58)	θ value	8.97725e-08 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

GNRP_HUMAN
NC score	0.521983 (rank : 59)	θ value	1.38499e-08 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	239	Shared Neighborhood Hits	75
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

FGD5_HUMAN
NC score	0.511707 (rank : 60)	θ value	7.84624e-12 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	65
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FARP2_HUMAN
NC score	0.507474 (rank : 61)	θ value	2.69047e-20 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_MOUSE
NC score	0.491293 (rank : 62)	θ value	2.0648e-12 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	64
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ITSN2_HUMAN
NC score	0.478801 (rank : 63)	θ value	6.20254e-17 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	1173	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RGNEF_MOUSE
NC score	0.474867 (rank : 64)	θ value	6.87365e-08 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	641	Shared Neighborhood Hits	68
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FARP1_HUMAN
NC score	0.462844 (rank : 65)	θ value	1.38178e-16 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	241	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ITSN2_MOUSE
NC score	0.451891 (rank : 66)	θ value	3.07829e-16 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	1371	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.442394 (rank : 67)	θ value	9.56915e-18 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	1757	Shared Neighborhood Hits	87
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ABR_HUMAN
NC score	0.442242 (rank : 68)	θ value	1.92812e-18 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ITSN1_MOUSE
NC score	0.441240 (rank : 69)	θ value	2.13179e-17 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	1669	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

BCR_HUMAN
NC score	0.438653 (rank : 70)	θ value	1.38178e-16 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SOS1_HUMAN
NC score	0.422833 (rank : 71)	θ value	1.68911e-14 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	274	Shared Neighborhood Hits	47
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.408991 (rank : 72)	θ value	5.8054e-15 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	281	Shared Neighborhood Hits	47
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
NC score	0.397852 (rank : 73)	θ value	5.62301e-10 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	193	Shared Neighborhood Hits	50
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

INP4A_HUMAN
NC score	0.297485 (rank : 74)	θ value	5.06226e-27 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q96PE3, O15326, Q13187, Q53TD8, Q8TC02	Gene names	INPP4A
Domain Architecture	No domain graphic available
Description	Type I inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I).

INP4A_MOUSE
NC score	0.296478 (rank : 75)	θ value	2.51237e-26 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EPW0, Q8CBJ8	Gene names	Inpp4a
Domain Architecture	No domain graphic available
Description	Type I inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I).

INP4B_HUMAN
NC score	0.284156 (rank : 76)	θ value	2.69047e-20 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	O15327, Q6IN59, Q6PJB4	Gene names	INPP4B
Domain Architecture	No domain graphic available
Description	Type II inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II).

INP4B_MOUSE
NC score	0.275785 (rank : 77)	θ value	1.80466e-16 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P1Y8	Gene names	Inpp4b
Domain Architecture	No domain graphic available
Description	Type II inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II).

PKHF2_HUMAN
NC score	0.269489 (rank : 78)	θ value	0.00175202 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.268890 (rank : 79)	θ value	0.00175202 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_HUMAN
NC score	0.252941 (rank : 80)	θ value	0.279714 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.251027 (rank : 81)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	80	Shared Neighborhood Hits	24
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

DUET_HUMAN
NC score	0.245744 (rank : 82)	θ value	1.2077e-20 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	1220	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.239269 (rank : 83)	θ value	3.63628e-17 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	1580	Shared Neighborhood Hits	84
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

RPGF4_MOUSE
NC score	0.200895 (rank : 84)	θ value	1.9326e-10 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	80	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.199784 (rank : 85)	θ value	4.30538e-10 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

NCF1_HUMAN
NC score	0.196460 (rank : 86)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3K1_HUMAN
NC score	0.190219 (rank : 87)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	177	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_MOUSE
NC score	0.181162 (rank : 88)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_HUMAN
NC score	0.180377 (rank : 89)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	177	Target Neighborhood Hits	315	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

RPGF5_MOUSE
NC score	0.179406 (rank : 90)	θ value	0.000121331 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF3_MOUSE
NC score	0.178826 (rank : 91)	θ value	1.99992e-07 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

SH3K1_MOUSE
NC score	0.178122 (rank : 92)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.177190 (rank : 93)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

RPGF3_HUMAN
NC score	0.176752 (rank : 94)	θ value	1.69304e-06 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

NCF2_HUMAN
NC score	0.161103 (rank : 95)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	177	Target Neighborhood Hits	229	Shared Neighborhood Hits	26
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SRBS1_HUMAN
NC score	0.160149 (rank : 96)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GP155_HUMAN
NC score	0.159394 (rank : 97)	θ value	8.11959e-09 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

SRBS1_MOUSE
NC score	0.158428 (rank : 98)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	177	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF4_HUMAN
NC score	0.158351 (rank : 99)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	177	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

FYV1_HUMAN
NC score	0.157883 (rank : 100)	θ value	0.000121331 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

NCF4_MOUSE
NC score	0.156588 (rank : 101)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

FYV1_MOUSE
NC score	0.155700 (rank : 102)	θ value	0.000121331 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY28_HUMAN
NC score	0.153480 (rank : 103)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	177	Target Neighborhood Hits	152	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

STAC_HUMAN
NC score	0.152738 (rank : 104)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	177	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP_HUMAN
NC score	0.152658 (rank : 105)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

RPGF5_HUMAN
NC score	0.152081 (rank : 106)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	177	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

VINEX_MOUSE
NC score	0.151295 (rank : 107)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	177	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP_MOUSE
NC score	0.150832 (rank : 108)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	177	Target Neighborhood Hits	309	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VINEX_HUMAN
NC score	0.150720 (rank : 109)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	177	Target Neighborhood Hits	270	Shared Neighborhood Hits	26
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCK1_HUMAN
NC score	0.149036 (rank : 110)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	29
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ZFYV9_HUMAN
NC score	0.148164 (rank : 111)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	177	Target Neighborhood Hits	134	Shared Neighborhood Hits	19
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

RPGF2_HUMAN
NC score	0.148020 (rank : 112)	θ value	0.62314 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	242	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

STAC_MOUSE
NC score	0.147268 (rank : 113)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	177	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ZFY21_MOUSE
NC score	0.143447 (rank : 114)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

NCK2_HUMAN
NC score	0.142977 (rank : 115)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	27
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ZFY16_MOUSE
NC score	0.141380 (rank : 116)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	177	Target Neighborhood Hits	108	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.141095 (rank : 117)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

RPGF6_HUMAN
NC score	0.140173 (rank : 118)	θ value	1.38821 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GRB2_HUMAN
NC score	0.138643 (rank : 119)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	24
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.138625 (rank : 120)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ZFY16_HUMAN
NC score	0.138099 (rank : 121)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	177	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

STAC3_MOUSE
NC score	0.135204 (rank : 122)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	177	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.134230 (rank : 123)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
NC score	0.134083 (rank : 124)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	177	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRP3_HUMAN
NC score	0.133610 (rank : 125)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	177	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF1_HUMAN
NC score	0.132664 (rank : 126)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	177	Target Neighborhood Hits	262	Shared Neighborhood Hits	16
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

STAM1_MOUSE
NC score	0.132547 (rank : 127)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	177	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_MOUSE
NC score	0.132054 (rank : 128)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.131942 (rank : 129)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	177	Target Neighborhood Hits	304	Shared Neighborhood Hits	22
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

HCLS1_MOUSE
NC score	0.128091 (rank : 130)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_HUMAN
NC score	0.127459 (rank : 131)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	177	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

HCLS1_HUMAN
NC score	0.126158 (rank : 132)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	177	Target Neighborhood Hits	358	Shared Neighborhood Hits	22
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

STAM2_MOUSE
NC score	0.125701 (rank : 133)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	177	Target Neighborhood Hits	285	Shared Neighborhood Hits	25
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SRC8_MOUSE
NC score	0.125556 (rank : 134)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	177	Target Neighborhood Hits	292	Shared Neighborhood Hits	25
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAM2_HUMAN
NC score	0.125217 (rank : 135)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SHAN2_MOUSE
NC score	0.123201 (rank : 136)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	177	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ABI2_MOUSE
NC score	0.121480 (rank : 137)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CRKL_HUMAN
NC score	0.121237 (rank : 138)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ABI2_HUMAN
NC score	0.121210 (rank : 139)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3G3_MOUSE
NC score	0.120959 (rank : 140)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	177	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G1_HUMAN
NC score	0.119489 (rank : 141)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G3_HUMAN
NC score	0.118695 (rank : 142)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	177	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRKL_MOUSE
NC score	0.118411 (rank : 143)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PPIP1_HUMAN
NC score	0.117919 (rank : 144)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	29
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI1_MOUSE
NC score	0.117218 (rank : 145)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

OBSCN_HUMAN
NC score	0.117039 (rank : 146)	θ value	9.59137e-10 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	1931	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

CRK_MOUSE
NC score	0.116946 (rank : 147)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3G2_HUMAN
NC score	0.115862 (rank : 148)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_MOUSE
NC score	0.115399 (rank : 149)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	177	Target Neighborhood Hits	291	Shared Neighborhood Hits	24
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CRK_HUMAN
NC score	0.113804 (rank : 150)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	177	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

RBNS5_HUMAN
NC score	0.113631 (rank : 151)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	177	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

SH3G2_MOUSE
NC score	0.113159 (rank : 152)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	177	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PPIP1_MOUSE
NC score	0.112288 (rank : 153)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	177	Target Neighborhood Hits	377	Shared Neighborhood Hits	28
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

BI2L1_HUMAN
NC score	0.111439 (rank : 154)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PLCG1_MOUSE
NC score	0.110022 (rank : 155)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.109014 (rank : 156)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	21
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

HGS_MOUSE
NC score	0.109000 (rank : 157)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	177	Target Neighborhood Hits	589	Shared Neighborhood Hits	25
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.108826 (rank : 158)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	177	Target Neighborhood Hits	517	Shared Neighborhood Hits	25
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ABI1_HUMAN
NC score	0.108658 (rank : 159)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

RBNS5_MOUSE
NC score	0.107901 (rank : 160)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	22
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

OSTF1_HUMAN
NC score	0.105181 (rank : 161)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	177	Target Neighborhood Hits	466	Shared Neighborhood Hits	22
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.104850 (rank : 162)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	177	Target Neighborhood Hits	467	Shared Neighborhood Hits	24
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

AHI1_HUMAN
NC score	0.104516 (rank : 163)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	537	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DBNL_HUMAN
NC score	0.104475 (rank : 164)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	177	Target Neighborhood Hits	244	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

TCGAP_MOUSE
NC score	0.102822 (rank : 165)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	177	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ABI3_HUMAN
NC score	0.101889 (rank : 166)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DBNL_MOUSE
NC score	0.101630 (rank : 167)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	177	Target Neighborhood Hits	306	Shared Neighborhood Hits	24
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

AHI1_MOUSE
NC score	0.101246 (rank : 168)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	496	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NPHP1_MOUSE
NC score	0.099625 (rank : 169)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

RHG04_HUMAN
NC score	0.099434 (rank : 170)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	25
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ABI3_MOUSE
NC score	0.098599 (rank : 171)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SHAN1_HUMAN
NC score	0.098406 (rank : 172)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	1041	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TCGAP_HUMAN
NC score	0.095184 (rank : 173)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	177	Target Neighborhood Hits	872	Shared Neighborhood Hits	39
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PLCG2_HUMAN
NC score	0.094964 (rank : 174)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	177	Target Neighborhood Hits	280	Shared Neighborhood Hits	17
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

LMO7_HUMAN
NC score	0.094810 (rank : 175)	θ value	2.36792 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	507	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

ANM2_HUMAN
NC score	0.094362 (rank : 176)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	19
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ZFY19_HUMAN
NC score	0.093705 (rank : 177)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	21
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFYV1_HUMAN
NC score	0.093642 (rank : 178)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	177	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.092047 (rank : 179)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	177	Target Neighborhood Hits	153	Shared Neighborhood Hits	19
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PEX13_MOUSE
NC score	0.091807 (rank : 180)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RGL1_HUMAN
NC score	0.091384 (rank : 181)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

PACN2_MOUSE
NC score	0.089017 (rank : 182)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	177	Target Neighborhood Hits	382	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.088326 (rank : 183)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	177	Target Neighborhood Hits	339	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PEX13_HUMAN
NC score	0.087852 (rank : 184)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	177	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ZFY19_MOUSE
NC score	0.087698 (rank : 185)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	177	Target Neighborhood Hits	143	Shared Neighborhood Hits	22
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

NOXO1_MOUSE
NC score	0.087234 (rank : 186)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	177	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ANM2_MOUSE
NC score	0.086370 (rank : 187)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BCAR1_MOUSE
NC score	0.086327 (rank : 188)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	177	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

LASP1_HUMAN
NC score	0.086127 (rank : 189)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BI2L1_MOUSE
NC score	0.085853 (rank : 190)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CT032_HUMAN
NC score	0.085672 (rank : 191)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

NOXO1_HUMAN
NC score	0.084527 (rank : 192)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BCAR1_HUMAN
NC score	0.084409 (rank : 193)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	177	Target Neighborhood Hits	554	Shared Neighborhood Hits	26
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

LASP1_MOUSE
NC score	0.083810 (rank : 194)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PKHA6_HUMAN
NC score	0.083269 (rank : 195)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	177	Target Neighborhood Hits	556	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RGL1_MOUSE
NC score	0.083261 (rank : 196)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	177	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

CASL_HUMAN
NC score	0.083019 (rank : 197)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	177	Target Neighborhood Hits	259	Shared Neighborhood Hits	21
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PDZD3_HUMAN
NC score	0.082515 (rank : 198)	θ value	0.0330416 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	180	Shared Neighborhood Hits	40
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SRGP1_HUMAN
NC score	0.081906 (rank : 199)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	177	Target Neighborhood Hits	390	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SPTA2_HUMAN
NC score	0.081359 (rank : 200)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	177	Target Neighborhood Hits	888	Shared Neighborhood Hits	37
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PKHA6_MOUSE
NC score	0.081345 (rank : 201)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	177	Target Neighborhood Hits	591	Shared Neighborhood Hits	26
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PACN3_MOUSE
NC score	0.080370 (rank : 202)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	177	Target Neighborhood Hits	380	Shared Neighborhood Hits	22
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NEBL_HUMAN
NC score	0.080098 (rank : 203)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	177	Target Neighborhood Hits	457	Shared Neighborhood Hits	26
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SPTA1_MOUSE
NC score	0.079291 (rank : 204)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	177	Target Neighborhood Hits	675	Shared Neighborhood Hits	30
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PACN3_HUMAN
NC score	0.079279 (rank : 205)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

FNBP2_HUMAN
NC score	0.078900 (rank : 206)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	177	Target Neighborhood Hits	432	Shared Neighborhood Hits	26
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CASL_MOUSE
NC score	0.078892 (rank : 207)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

RUFY2_MOUSE
NC score	0.078552 (rank : 208)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	177	Target Neighborhood Hits	820	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PACN1_HUMAN
NC score	0.078519 (rank : 209)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	177	Target Neighborhood Hits	320	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SRGP2_MOUSE
NC score	0.078324 (rank : 210)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	25
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RIMB2_HUMAN
NC score	0.078091 (rank : 211)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	177	Target Neighborhood Hits	263	Shared Neighborhood Hits	20
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

WDFY1_HUMAN
NC score	0.078080 (rank : 212)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	177	Target Neighborhood Hits	305	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

PACN1_MOUSE
NC score	0.077519 (rank : 213)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	177	Target Neighborhood Hits	283	Shared Neighborhood Hits	22
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SRGP2_HUMAN
NC score	0.077186 (rank : 214)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	177	Target Neighborhood Hits	331	Shared Neighborhood Hits	25
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RIMB2_MOUSE
NC score	0.077135 (rank : 215)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	177	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUFY1_MOUSE
NC score	0.077128 (rank : 216)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	177	Target Neighborhood Hits	765	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

PLEK_HUMAN
NC score	0.076965 (rank : 217)	θ value	0.365318 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

ALS2_MOUSE
NC score	0.076565 (rank : 218)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SPTA1_HUMAN
NC score	0.076350 (rank : 219)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	177	Target Neighborhood Hits	748	Shared Neighborhood Hits	36
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RUFY1_HUMAN
NC score	0.076306 (rank : 220)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	177	Target Neighborhood Hits	848	Shared Neighborhood Hits	34
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY3_HUMAN
NC score	0.075465 (rank : 221)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	177	Target Neighborhood Hits	348	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

EFS_MOUSE
NC score	0.074889 (rank : 222)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	23
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RHG26_HUMAN
NC score	0.074767 (rank : 223)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	177	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

PLEK_MOUSE
NC score	0.074765 (rank : 224)	θ value	1.06291 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

WDFY3_MOUSE
NC score	0.074706 (rank : 225)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	20
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

PDZD3_MOUSE
NC score	0.074506 (rank : 226)	θ value	0.0961366 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

NPHP1_HUMAN
NC score	0.073889 (rank : 227)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	26
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RGL2_HUMAN
NC score	0.073872 (rank : 228)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

NEBU_HUMAN
NC score	0.072534 (rank : 229)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	177	Target Neighborhood Hits	420	Shared Neighborhood Hits	27
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

GNDS_MOUSE
NC score	0.072150 (rank : 230)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_MOUSE
NC score	0.071622 (rank : 231)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

MTMR3_HUMAN
NC score	0.071239 (rank : 232)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	177	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PDZD1_MOUSE
NC score	0.071206 (rank : 233)	θ value	0.21417 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	191	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

GNDS_HUMAN
NC score	0.070958 (rank : 234)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	177	Target Neighborhood Hits	201	Shared Neighborhood Hits	14
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RUFY2_HUMAN
NC score	0.070469 (rank : 235)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	177	Target Neighborhood Hits	1208	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PLEK2_MOUSE
NC score	0.070402 (rank : 236)	θ value	0.0563607 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.070072 (rank : 237)	θ value	0.21417 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

IASPP_MOUSE
NC score	0.069611 (rank : 238)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	177	Target Neighborhood Hits	1024	Shared Neighborhood Hits	32
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

APBA3_HUMAN
NC score	0.069546 (rank : 239)	θ value	0.125558 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	201	Shared Neighborhood Hits	40
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

EFS_HUMAN
NC score	0.069541 (rank : 240)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	177	Target Neighborhood Hits	348	Shared Neighborhood Hits	20
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

RGDSR_HUMAN
NC score	0.068681 (rank : 241)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	177	Target Neighborhood Hits	63	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

ASPP1_MOUSE
NC score	0.068472 (rank : 242)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	1244	Shared Neighborhood Hits	34
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

WHRN_HUMAN
NC score	0.067683 (rank : 243)	θ value	0.163984 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	325	Shared Neighborhood Hits	49
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.067247 (rank : 244)	θ value	0.0736092 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	412	Shared Neighborhood Hits	48
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

DDEF2_MOUSE
NC score	0.066881 (rank : 245)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	177	Target Neighborhood Hits	625	Shared Neighborhood Hits	29
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

IASPP_HUMAN
NC score	0.066835 (rank : 246)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	177	Target Neighborhood Hits	688	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DDEF2_HUMAN
NC score	0.066624 (rank : 247)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	177	Target Neighborhood Hits	599	Shared Neighborhood Hits	30
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ALS2_HUMAN
NC score	0.066502 (rank : 248)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

EEA1_MOUSE
NC score	0.066494 (rank : 249)	θ value	5.27518 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	1637	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

WDFY2_MOUSE
NC score	0.066430 (rank : 250)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	177	Target Neighborhood Hits	337	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

APBA1_HUMAN
NC score	0.066309 (rank : 251)	θ value	0.0252991 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

WDFY2_HUMAN
NC score	0.065922 (rank : 252)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	19
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

NHERF_HUMAN
NC score	0.065730 (rank : 253)	θ value	0.21417 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	37
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

BAIP2_MOUSE
NC score	0.065302 (rank : 254)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	177	Target Neighborhood Hits	185	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ASPP1_HUMAN
NC score	0.065286 (rank : 255)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	956	Shared Neighborhood Hits	27
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

P85A_HUMAN
NC score	0.064034 (rank : 256)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	177	Target Neighborhood Hits	479	Shared Neighborhood Hits	18
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PDZD1_HUMAN
NC score	0.064009 (rank : 257)	θ value	1.38821 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

BAIP2_HUMAN
NC score	0.063864 (rank : 258)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	192	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

DVL3_HUMAN
NC score	0.063136 (rank : 259)	θ value	0.47712 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	194	Shared Neighborhood Hits	40
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

SDCB1_HUMAN
NC score	0.062702 (rank : 260)	θ value	0.365318 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

APBA2_MOUSE
NC score	0.062351 (rank : 261)	θ value	0.813845 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DVL3_MOUSE
NC score	0.062266 (rank : 262)	θ value	0.279714 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

TX1B3_MOUSE
NC score	0.061847 (rank : 263)	θ value	0.365318 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

TX1B3_HUMAN
NC score	0.061802 (rank : 264)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	161	Shared Neighborhood Hits	43
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

SDCB1_MOUSE
NC score	0.061729 (rank : 265)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

APBA2_HUMAN
NC score	0.061329 (rank : 266)	θ value	0.813845 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

NHERF_MOUSE
NC score	0.061178 (rank : 267)	θ value	0.813845 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	195	Shared Neighborhood Hits	38
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

P85A_MOUSE
NC score	0.060977 (rank : 268)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	17
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MIA_MOUSE
NC score	0.060968 (rank : 269)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	177	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

SNX18_MOUSE
NC score	0.060898 (rank : 270)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CNN1_HUMAN
NC score	0.060864 (rank : 271)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	177	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
NC score	0.060734 (rank : 272)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

P85B_HUMAN
NC score	0.060612 (rank : 273)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	20
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

MIA_HUMAN
NC score	0.060346 (rank : 274)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	177	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

CNN2_MOUSE
NC score	0.059987 (rank : 275)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	177	Target Neighborhood Hits	39	Shared Neighborhood Hits	10
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

DVL2_MOUSE
NC score	0.059982 (rank : 276)	θ value	0.0961366 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	233	Shared Neighborhood Hits	38
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

EEA1_HUMAN
NC score	0.059830 (rank : 277)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	177	Target Neighborhood Hits	1796	Shared Neighborhood Hits	46
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

APBA3_MOUSE
NC score	0.059378 (rank : 278)	θ value	1.06291 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	32
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

DDEF1_MOUSE
NC score	0.059294 (rank : 279)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	177	Target Neighborhood Hits	592	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO1F_MOUSE
NC score	0.059217 (rank : 280)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	177	Target Neighborhood Hits	262	Shared Neighborhood Hits	28
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PDZD7_HUMAN
NC score	0.058892 (rank : 281)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	181	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

DVL2_HUMAN
NC score	0.058722 (rank : 282)	θ value	0.0961366 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	223	Shared Neighborhood Hits	36
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SNX18_HUMAN
NC score	0.058696 (rank : 283)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	177	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

P85B_MOUSE
NC score	0.058581 (rank : 284)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	177	Target Neighborhood Hits	519	Shared Neighborhood Hits	20
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DVL1L_HUMAN
NC score	0.058149 (rank : 285)	θ value	0.47712 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	146	Shared Neighborhood Hits	34
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_MOUSE
NC score	0.058023 (rank : 286)	θ value	0.813845 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

MYO1F_HUMAN
NC score	0.058001 (rank : 287)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	177	Target Neighborhood Hits	275	Shared Neighborhood Hits	26
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

DVL1_HUMAN
NC score	0.057934 (rank : 288)	θ value	0.47712 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	35
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

MYO1E_HUMAN
NC score	0.057506 (rank : 289)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CNN3_MOUSE
NC score	0.057399 (rank : 290)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_HUMAN
NC score	0.057269 (rank : 291)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

NHRF2_HUMAN
NC score	0.056866 (rank : 292)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

CNN2_HUMAN
NC score	0.056216 (rank : 293)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	10
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

FYCO1_HUMAN
NC score	0.056114 (rank : 294)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	177	Target Neighborhood Hits	1149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

REPS2_MOUSE
NC score	0.055450 (rank : 295)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_HUMAN
NC score	0.055306 (rank : 296)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	177	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

PKHA5_HUMAN
NC score	0.055033 (rank : 297)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

NHRF2_MOUSE
NC score	0.054730 (rank : 298)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	177	Target Neighborhood Hits	194	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PKHA4_MOUSE
NC score	0.054693 (rank : 299)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	177	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

REPS1_MOUSE
NC score	0.054283 (rank : 300)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

FYCO1_MOUSE
NC score	0.053954 (rank : 301)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	177	Target Neighborhood Hits	1059	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

USH1C_HUMAN
NC score	0.052297 (rank : 302)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	177	Target Neighborhood Hits	327	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

SNX9_HUMAN
NC score	0.052121 (rank : 303)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	177	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

PKHA4_HUMAN
NC score	0.051440 (rank : 304)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	177	Target Neighborhood Hits	283	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RGS7_HUMAN
NC score	0.051212 (rank : 305)	θ value	0.0252991 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	82	Shared Neighborhood Hits	16
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_MOUSE
NC score	0.051004 (rank : 306)	θ value	0.0252991 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

USH1C_MOUSE
NC score	0.050411 (rank : 307)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	177	Target Neighborhood Hits	557	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

RGS6_HUMAN
NC score	0.049673 (rank : 308)	θ value	0.0961366 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS6_MOUSE
NC score	0.048161 (rank : 309)	θ value	0.0961366 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

RHPN1_MOUSE
NC score	0.047692 (rank : 310)	θ value	1.81305 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	154	Shared Neighborhood Hits	31
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_HUMAN
NC score	0.046260 (rank : 311)	θ value	1.06291 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	158	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PARD3_HUMAN
NC score	0.045384 (rank : 312)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

OSBL9_HUMAN
NC score	0.044729 (rank : 313)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	138	Shared Neighborhood Hits	25
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

SDCB2_MOUSE
NC score	0.044446 (rank : 314)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PARD3_MOUSE
NC score	0.044173 (rank : 315)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	48
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

RGS11_HUMAN
NC score	0.042264 (rank : 316)	θ value	0.813845 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	O94810, O75883	Gene names	RGS11
Domain Architecture
Description	Regulator of G-protein signaling 11 (RGS11).

GRIP1_MOUSE
NC score	0.039610 (rank : 317)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	241	Shared Neighborhood Hits	47
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_HUMAN
NC score	0.038896 (rank : 318)	θ value	5.27518 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	231	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

RGS9_HUMAN
NC score	0.038182 (rank : 319)	θ value	1.38821 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	64	Shared Neighborhood Hits	16
SwissProt Accessions	O75916, O75573, Q696R2, Q8TD64, Q8TD65, Q9HC32, Q9HC33	Gene names	RGS9
Domain Architecture
Description	Regulator of G-protein signaling 9 (RGS9).

CYH1_HUMAN
NC score	0.032235 (rank : 320)	θ value	0.365318 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

MPP3_MOUSE
NC score	0.030413 (rank : 321)	θ value	1.81305 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP3_HUMAN
NC score	0.030344 (rank : 322)	θ value	1.06291 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MY18A_HUMAN
NC score	0.022692 (rank : 323)	θ value	0.62314 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	1929	Shared Neighborhood Hits	63
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
NC score	0.021337 (rank : 324)	θ value	0.62314 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	1989	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

DEPD5_MOUSE
NC score	0.021221 (rank : 325)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

RS17_MOUSE
NC score	0.019785 (rank : 326)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P63276, P06584	Gene names	Rps17
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S17.

RS17_HUMAN
NC score	0.019775 (rank : 327)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P08708	Gene names	RPS17
Domain Architecture
Description	40S ribosomal protein S17.

SYCP1_MOUSE
NC score	0.019357 (rank : 328)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	1456	Shared Neighborhood Hits	29
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

RAI1_MOUSE
NC score	0.018985 (rank : 329)	θ value	0.813845 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	344	Shared Neighborhood Hits	4
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

PUR8_HUMAN
NC score	0.018005 (rank : 330)	θ value	1.81305 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P30566, O75495, Q5TI34	Gene names	ADSL, AMPS
Domain Architecture
Description	Adenylosuccinate lyase (EC 4.3.2.2) (Adenylosuccinase) (ASL) (ASASE).

CAR10_HUMAN
NC score	0.017629 (rank : 331)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	569	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CCD41_HUMAN
NC score	0.016658 (rank : 332)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	1139	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

YTDC1_HUMAN
NC score	0.016286 (rank : 333)	θ value	1.06291 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	458	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

TNNT2_HUMAN
NC score	0.016243 (rank : 334)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	433	Shared Neighborhood Hits	14
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

MAST1_HUMAN
NC score	0.015845 (rank : 335)	θ value	0.163984 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	1146	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
NC score	0.015002 (rank : 336)	θ value	0.279714 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	1123	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SHBG_MOUSE
NC score	0.014901 (rank : 337)	θ value	1.81305 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P97497	Gene names	Shbg
Domain Architecture
Description	Sex hormone-binding globulin precursor (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP).

RAI1_HUMAN
NC score	0.014482 (rank : 338)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

DDB1_HUMAN
NC score	0.013851 (rank : 339)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q16531, O15176, Q13289, Q58F96	Gene names	DDB1
Domain Architecture
Description	DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor) (DDB p127 subunit) (DDBa) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (Xeroderma pigmentosum group E- complementing protein) (XPCe) (XPE-binding factor) (XPE-BF) (X- associated protein 1) (XAP-1).

SGOL1_MOUSE
NC score	0.013586 (rank : 340)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CXH7, Q3U4K4, Q588H1, Q8BKW2	Gene names	Sgol1, Sgo1
Domain Architecture	No domain graphic available
Description	Shugoshin-like 1.

CAR10_MOUSE
NC score	0.012975 (rank : 341)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	407	Shared Neighborhood Hits	15
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

LRRF2_MOUSE
NC score	0.012025 (rank : 342)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	556	Shared Neighborhood Hits	11
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

K0090_MOUSE
NC score	0.011551 (rank : 343)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C7X2, Q3TCG4, Q6ZQJ4, Q8K3W8	Gene names	Kiaa0090
Domain Architecture	No domain graphic available
Description	Protein KIAA0090 precursor.

AP1G2_HUMAN
NC score	0.008398 (rank : 344)	θ value	1.81305 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

HUWE1_MOUSE
NC score	0.007655 (rank : 345)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	406	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.006657 (rank : 346)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	443	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

SARM1_MOUSE
NC score	0.006195 (rank : 347)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDS3, Q5SYG5, Q5SYG6, Q6A054, Q6SZW0, Q8BRI9	Gene names	Sarm1, Kiaa0524
Domain Architecture	No domain graphic available
Description	Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog).

SL9A5_HUMAN
NC score	0.006019 (rank : 348)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q14940, Q9Y626	Gene names	SLC9A5, NHE5
Domain Architecture
Description	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5).

HNRPC_MOUSE
NC score	0.005213 (rank : 349)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z204, Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83	Gene names	Hnrpc, Hnrnpc
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

CEAM7_HUMAN
NC score	0.002994 (rank : 350)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

IFIH1_HUMAN
NC score	0.002918 (rank : 351)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

P3C2A_HUMAN
NC score	0.001924 (rank : 352)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

LEO1_HUMAN
NC score	0.000881 (rank : 353)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LAMB1_MOUSE
NC score	-0.002170 (rank : 354)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	919	Shared Neighborhood Hits	11
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

HIC1_MOUSE
NC score	-0.006139 (rank : 355)	θ value	1.81305 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	863	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

PRDM5_MOUSE
NC score	-0.007931 (rank : 356)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	774	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CXE0	Gene names	Prdm5
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 5 (PR domain-containing protein 5).