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Network neighborhood for query Sequence : RGL2_HUMAN

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RGL2_HUMAN
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RGL2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
θ value	0 (rank : 2)	NC score	0.995177 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	51	Shared Neighborhood Hits	29
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL1_MOUSE
θ value	1.76739e-88 (rank : 3)	NC score	0.939693 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_HUMAN
θ value	4.82422e-78 (rank : 4)	NC score	0.899226 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	201	Shared Neighborhood Hits	24
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_MOUSE
θ value	1.89707e-74 (rank : 5)	NC score	0.912978 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	115	Shared Neighborhood Hits	24
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_HUMAN
θ value	1.7756e-72 (rank : 6)	NC score	0.930711 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGDSR_HUMAN
θ value	1.46607e-42 (rank : 7)	NC score	0.892352 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

SOS1_MOUSE
θ value	2.97466e-19 (rank : 8)	NC score	0.577904 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	281	Shared Neighborhood Hits	28
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	1.13037e-18 (rank : 9)	NC score	0.598679 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	193	Shared Neighborhood Hits	21
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_MOUSE
θ value	7.32683e-18 (rank : 10)	NC score	0.561442 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
θ value	1.24977e-17 (rank : 11)	NC score	0.574049 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS1_HUMAN
θ value	2.7842e-17 (rank : 12)	NC score	0.572847 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

RPGF1_HUMAN
θ value	4.74913e-17 (rank : 13)	NC score	0.685229 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GRP3_HUMAN
θ value	7.09661e-13 (rank : 14)	NC score	0.519726 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF2_HUMAN
θ value	7.84624e-12 (rank : 15)	NC score	0.501992 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	1.63604e-09 (rank : 16)	NC score	0.481740 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF3_HUMAN
θ value	1.69304e-06 (rank : 17)	NC score	0.381938 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF4_HUMAN
θ value	8.40245e-06 (rank : 18)	NC score	0.419843 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	88	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	1.09739e-05 (rank : 19)	NC score	0.415920 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF5_HUMAN
θ value	5.44631e-05 (rank : 20)	NC score	0.466306 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
θ value	5.44631e-05 (rank : 21)	NC score	0.451377 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

PRD15_HUMAN
θ value	0.365318 (rank : 22)	NC score	0.001203 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	805	Shared Neighborhood Hits	4
SwissProt Accessions	P57071, Q8N0X3, Q8NEX0, Q9NQV3	Gene names	PRDM15, C21orf83, ZNF298
Domain Architecture
Description	PR domain zinc finger protein 15 (PR domain-containing protein 15) (Zinc finger protein 298).

MDC1_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.037462 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	1446	Shared Neighborhood Hits	19
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SFR15_HUMAN
θ value	0.813845 (rank : 24)	NC score	0.039196 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	368	Shared Neighborhood Hits	11
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

WNT6_MOUSE
θ value	0.813845 (rank : 25)	NC score	0.017502 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P22727	Gene names	Wnt6, Wnt-6
Domain Architecture
Description	Protein Wnt-6 precursor.

PDZD2_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.023930 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

WNT6_HUMAN
θ value	1.06291 (rank : 27)	NC score	0.016644 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6F9, Q9H1J6, Q9H238	Gene names	WNT6
Domain Architecture
Description	Protein Wnt-6 precursor.

BSN_MOUSE
θ value	1.38821 (rank : 28)	NC score	0.025776 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	2057	Shared Neighborhood Hits	21
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

SIAH2_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.017601 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	101	Shared Neighborhood Hits	4
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

BSN_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.019893 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	1537	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

MUC1_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.028488 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	975	Shared Neighborhood Hits	18
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

UBP42_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.013292 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	445	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

CECR2_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.021620 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

MTR1L_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.003462 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	1180	Shared Neighborhood Hits	11
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

SSF1_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.029733 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YU8	Gene names	Ppan
Domain Architecture
Description	Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog).

3BP2_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.024535 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	296	Shared Neighborhood Hits	10
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

TCGAP_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.017914 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	872	Shared Neighborhood Hits	15
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

IF4G3_MOUSE
θ value	5.27518 (rank : 38)	NC score	0.009807 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

MYO9B_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.005299 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	641	Shared Neighborhood Hits	11
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

VKGC_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.014180 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P38435, Q14415, Q6GU45	Gene names	GGCX, GC
Domain Architecture
Description	Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) (Gamma-glutamyl carboxylase) (Vitamin K gamma glutamyl carboxylase).

MEFV_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.004621 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	431	Shared Neighborhood Hits	5
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

CMTA2_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.008438 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	199	Shared Neighborhood Hits	7
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

MLL4_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.009471 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	722	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NKX24_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.001571 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	356	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EQM3, Q9EQM4	Gene names	Nkx2-4, Nkx2d
Domain Architecture
Description	Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D).

TCGAP_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.010208 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	409	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CB027_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.055865 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ECT2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.051891 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.073872 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RPGF3_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.314999 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

Hits sorted by NC score

RGL2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
NC score	0.995177 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	51	Shared Neighborhood Hits	29
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL1_MOUSE
NC score	0.939693 (rank : 3)	θ value	1.76739e-88 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_HUMAN
NC score	0.930711 (rank : 4)	θ value	1.7756e-72 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.912978 (rank : 5)	θ value	1.89707e-74 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	115	Shared Neighborhood Hits	24
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
NC score	0.899226 (rank : 6)	θ value	4.82422e-78 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	201	Shared Neighborhood Hits	24
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGDSR_HUMAN
NC score	0.892352 (rank : 7)	θ value	1.46607e-42 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF1_HUMAN
NC score	0.685229 (rank : 8)	θ value	4.74913e-17 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS2_HUMAN
NC score	0.598679 (rank : 9)	θ value	1.13037e-18 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	193	Shared Neighborhood Hits	21
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
NC score	0.577904 (rank : 10)	θ value	2.97466e-19 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	281	Shared Neighborhood Hits	28
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

GNRP_HUMAN
NC score	0.574049 (rank : 11)	θ value	1.24977e-17 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS1_HUMAN
NC score	0.572847 (rank : 12)	θ value	2.7842e-17 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	274	Shared Neighborhood Hits	27
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GNRP_MOUSE
NC score	0.561442 (rank : 13)	θ value	7.32683e-18 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRP3_HUMAN
NC score	0.519726 (rank : 14)	θ value	7.09661e-13 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF2_HUMAN
NC score	0.501992 (rank : 15)	θ value	7.84624e-12 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.481740 (rank : 16)	θ value	1.63604e-09 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF5_HUMAN
NC score	0.466306 (rank : 17)	θ value	5.44631e-05 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
NC score	0.451377 (rank : 18)	θ value	5.44631e-05 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.419843 (rank : 19)	θ value	8.40245e-06 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	88	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.415920 (rank : 20)	θ value	1.09739e-05 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.381938 (rank : 21)	θ value	1.69304e-06 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.314999 (rank : 22)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
NC score	0.073872 (rank : 23)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CB027_HUMAN
NC score	0.055865 (rank : 24)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ECT2_HUMAN
NC score	0.051891 (rank : 25)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SFR15_HUMAN
NC score	0.039196 (rank : 26)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	368	Shared Neighborhood Hits	11
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

MDC1_HUMAN
NC score	0.037462 (rank : 27)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	1446	Shared Neighborhood Hits	19
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SSF1_MOUSE
NC score	0.029733 (rank : 28)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q91YU8	Gene names	Ppan
Domain Architecture
Description	Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog).

MUC1_HUMAN
NC score	0.028488 (rank : 29)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	975	Shared Neighborhood Hits	18
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

BSN_MOUSE
NC score	0.025776 (rank : 30)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	2057	Shared Neighborhood Hits	21
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

3BP2_HUMAN
NC score	0.024535 (rank : 31)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	296	Shared Neighborhood Hits	10
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PDZD2_HUMAN
NC score	0.023930 (rank : 32)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

CECR2_HUMAN
NC score	0.021620 (rank : 33)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

BSN_HUMAN
NC score	0.019893 (rank : 34)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	1537	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

TCGAP_HUMAN
NC score	0.017914 (rank : 35)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	872	Shared Neighborhood Hits	15
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SIAH2_MOUSE
NC score	0.017601 (rank : 36)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	101	Shared Neighborhood Hits	4
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

WNT6_MOUSE
NC score	0.017502 (rank : 37)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P22727	Gene names	Wnt6, Wnt-6
Domain Architecture
Description	Protein Wnt-6 precursor.

WNT6_HUMAN
NC score	0.016644 (rank : 38)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6F9, Q9H1J6, Q9H238	Gene names	WNT6
Domain Architecture
Description	Protein Wnt-6 precursor.

VKGC_HUMAN
NC score	0.014180 (rank : 39)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P38435, Q14415, Q6GU45	Gene names	GGCX, GC
Domain Architecture
Description	Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) (Gamma-glutamyl carboxylase) (Vitamin K gamma glutamyl carboxylase).

UBP42_HUMAN
NC score	0.013292 (rank : 40)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	445	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

TCGAP_MOUSE
NC score	0.010208 (rank : 41)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	409	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

IF4G3_MOUSE
NC score	0.009807 (rank : 42)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

MLL4_HUMAN
NC score	0.009471 (rank : 43)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	722	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

CMTA2_HUMAN
NC score	0.008438 (rank : 44)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	199	Shared Neighborhood Hits	7
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

MYO9B_HUMAN
NC score	0.005299 (rank : 45)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	641	Shared Neighborhood Hits	11
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MEFV_HUMAN
NC score	0.004621 (rank : 46)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	431	Shared Neighborhood Hits	5
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MTR1L_HUMAN
NC score	0.003462 (rank : 47)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	1180	Shared Neighborhood Hits	11
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

NKX24_MOUSE
NC score	0.001571 (rank : 48)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	356	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EQM3, Q9EQM4	Gene names	Nkx2-4, Nkx2d
Domain Architecture
Description	Homeobox protein Nkx-2.4 (Homeobox protein NKX2.4) (Homeobox protein NK-2 homolog D).

PRD15_HUMAN
NC score	0.001203 (rank : 49)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	805	Shared Neighborhood Hits	4
SwissProt Accessions	P57071, Q8N0X3, Q8NEX0, Q9NQV3	Gene names	PRDM15, C21orf83, ZNF298
Domain Architecture
Description	PR domain zinc finger protein 15 (PR domain-containing protein 15) (Zinc finger protein 298).