Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : SOS1_MOUSE

For an explanation of this page, click here

SOS1_MOUSE
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SOS1_HUMAN
θ value	0 (rank : 1)	NC score	0.990321 (rank : 2)
Query Neighborhood Hits	281	Target Neighborhood Hits	274	Shared Neighborhood Hits	229
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	281
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	0 (rank : 3)	NC score	0.960617 (rank : 3)
Query Neighborhood Hits	281	Target Neighborhood Hits	193	Shared Neighborhood Hits	115
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_MOUSE
θ value	4.13158e-37 (rank : 4)	NC score	0.664183 (rank : 5)
Query Neighborhood Hits	281	Target Neighborhood Hits	191	Shared Neighborhood Hits	58
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
θ value	1.20211e-36 (rank : 5)	NC score	0.648322 (rank : 6)
Query Neighborhood Hits	281	Target Neighborhood Hits	239	Shared Neighborhood Hits	56
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RPGF1_HUMAN
θ value	1.98606e-31 (rank : 6)	NC score	0.669574 (rank : 4)
Query Neighborhood Hits	281	Target Neighborhood Hits	262	Shared Neighborhood Hits	37
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RGL1_HUMAN
θ value	1.12775e-26 (rank : 7)	NC score	0.609755 (rank : 7)
Query Neighborhood Hits	281	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	8.08199e-25 (rank : 8)	NC score	0.593599 (rank : 8)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	23
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RPGF4_HUMAN
θ value	1.5773e-20 (rank : 9)	NC score	0.524112 (rank : 16)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	5.99374e-20 (rank : 10)	NC score	0.520960 (rank : 17)
Query Neighborhood Hits	281	Target Neighborhood Hits	80	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RGL2_HUMAN
θ value	2.97466e-19 (rank : 11)	NC score	0.577904 (rank : 9)
Query Neighborhood Hits	281	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF5_MOUSE
θ value	9.56915e-18 (rank : 12)	NC score	0.548563 (rank : 15)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF2_HUMAN
θ value	2.13179e-17 (rank : 13)	NC score	0.503759 (rank : 18)
Query Neighborhood Hits	281	Target Neighborhood Hits	242	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

GNDS_HUMAN
θ value	8.10077e-17 (rank : 14)	NC score	0.553754 (rank : 13)
Query Neighborhood Hits	281	Target Neighborhood Hits	201	Shared Neighborhood Hits	52
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF5_HUMAN
θ value	1.80466e-16 (rank : 15)	NC score	0.554013 (rank : 12)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF6_HUMAN
θ value	1.80466e-16 (rank : 16)	NC score	0.482520 (rank : 20)
Query Neighborhood Hits	281	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RGL2_MOUSE
θ value	8.95645e-16 (rank : 17)	NC score	0.562678 (rank : 10)
Query Neighborhood Hits	281	Target Neighborhood Hits	51	Shared Neighborhood Hits	26
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_MOUSE
θ value	3.40345e-15 (rank : 18)	NC score	0.555893 (rank : 11)
Query Neighborhood Hits	281	Target Neighborhood Hits	115	Shared Neighborhood Hits	45
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

PREX1_HUMAN
θ value	5.8054e-15 (rank : 19)	NC score	0.408991 (rank : 23)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

GRP3_HUMAN
θ value	1.29331e-14 (rank : 20)	NC score	0.485812 (rank : 19)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

ARHG9_MOUSE
θ value	1.68911e-14 (rank : 21)	NC score	0.378979 (rank : 24)
Query Neighborhood Hits	281	Target Neighborhood Hits	234	Shared Neighborhood Hits	39
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
θ value	2.20605e-14 (rank : 22)	NC score	0.378399 (rank : 25)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

RGDSR_HUMAN
θ value	3.18553e-13 (rank : 23)	NC score	0.551250 (rank : 14)
Query Neighborhood Hits	281	Target Neighborhood Hits	63	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

ARHG4_HUMAN
θ value	5.43371e-13 (rank : 24)	NC score	0.367449 (rank : 27)
Query Neighborhood Hits	281	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	9.26847e-13 (rank : 25)	NC score	0.375029 (rank : 26)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RPGF3_HUMAN
θ value	1.2105e-12 (rank : 26)	NC score	0.479933 (rank : 21)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	2.98157e-11 (rank : 27)	NC score	0.458177 (rank : 22)
Query Neighborhood Hits	281	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PKHG1_HUMAN
θ value	1.9326e-10 (rank : 28)	NC score	0.353841 (rank : 28)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG7_HUMAN
θ value	2.13673e-09 (rank : 29)	NC score	0.300922 (rank : 63)
Query Neighborhood Hits	281	Target Neighborhood Hits	347	Shared Neighborhood Hits	48
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV3_MOUSE
θ value	6.21693e-09 (rank : 30)	NC score	0.248205 (rank : 73)
Query Neighborhood Hits	281	Target Neighborhood Hits	404	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FGD4_MOUSE
θ value	1.38499e-08 (rank : 31)	NC score	0.307938 (rank : 57)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	4.0297e-08 (rank : 32)	NC score	0.308058 (rank : 56)
Query Neighborhood Hits	281	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG7_MOUSE
θ value	6.87365e-08 (rank : 33)	NC score	0.295945 (rank : 66)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_HUMAN
θ value	1.17247e-07 (rank : 34)	NC score	0.239188 (rank : 78)
Query Neighborhood Hits	281	Target Neighborhood Hits	398	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FGD3_HUMAN
θ value	5.81887e-07 (rank : 35)	NC score	0.307848 (rank : 58)
Query Neighborhood Hits	281	Target Neighborhood Hits	249	Shared Neighborhood Hits	40
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FARP2_HUMAN
θ value	9.92553e-07 (rank : 36)	NC score	0.221992 (rank : 83)
Query Neighborhood Hits	281	Target Neighborhood Hits	240	Shared Neighborhood Hits	52
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

VAV2_MOUSE
θ value	9.92553e-07 (rank : 37)	NC score	0.247994 (rank : 74)
Query Neighborhood Hits	281	Target Neighborhood Hits	456	Shared Neighborhood Hits	48
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FARP2_MOUSE
θ value	3.77169e-06 (rank : 38)	NC score	0.230223 (rank : 80)
Query Neighborhood Hits	281	Target Neighborhood Hits	209	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ECT2_HUMAN
θ value	6.43352e-06 (rank : 39)	NC score	0.302150 (rank : 62)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

H2A1B_HUMAN
θ value	6.43352e-06 (rank : 40)	NC score	0.335483 (rank : 34)
Query Neighborhood Hits	281	Target Neighborhood Hits	39	Shared Neighborhood Hits	34
SwissProt Accessions	P04908	Gene names	HIST1H2AB, H2AFM
Domain Architecture
Description	Histone H2A type 1-B.

H2A1C_HUMAN
θ value	1.09739e-05 (rank : 41)	NC score	0.332941 (rank : 40)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q93077, O00775, O00776, O00777, O00778, Q540R1	Gene names	HIST1H2AC, H2AFL
Domain Architecture
Description	Histone H2A type 1-C.

H2A2B_HUMAN
θ value	1.09739e-05 (rank : 42)	NC score	0.333664 (rank : 37)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IUE6	Gene names	HIST2H2AB
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B.

H2A3_HUMAN
θ value	1.09739e-05 (rank : 43)	NC score	0.332944 (rank : 38)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q7L7L0	Gene names	HIST3H2A
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2A3_MOUSE
θ value	1.09739e-05 (rank : 44)	NC score	0.332944 (rank : 39)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BFU2	Gene names	Hist3h2a
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2AX_HUMAN
θ value	1.09739e-05 (rank : 45)	NC score	0.334220 (rank : 36)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P16104, Q4ZGJ7, Q6IAS5	Gene names	H2AFX, H2AX
Domain Architecture
Description	Histone H2A.x (H2a/x).

H2AX_MOUSE
θ value	1.09739e-05 (rank : 46)	NC score	0.334396 (rank : 35)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P27661	Gene names	H2afx, H2a.x, H2ax, Hist5-2ax
Domain Architecture
Description	Histone H2A.x (H2a/x).

FGD3_MOUSE
θ value	1.43324e-05 (rank : 47)	NC score	0.302821 (rank : 61)
Query Neighborhood Hits	281	Target Neighborhood Hits	257	Shared Neighborhood Hits	46
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

H2A1A_HUMAN
θ value	1.43324e-05 (rank : 48)	NC score	0.332168 (rank : 53)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96QV6	Gene names	HIST1H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-A.

H2A1D_HUMAN
θ value	1.43324e-05 (rank : 49)	NC score	0.332206 (rank : 51)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P20671, P57754, Q6FGY6	Gene names	HIST1H2AD, H2AFG
Domain Architecture
Description	Histone H2A type 1-D (H2A.3).

H2A1E_HUMAN
θ value	1.43324e-05 (rank : 50)	NC score	0.332211 (rank : 49)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P28001, Q76P63	Gene names	HIST1H2AE, H2AFA
Domain Architecture
Description	Histone H2A type 1-E (H2A.2) (H2A/m).

H2A1F_MOUSE
θ value	1.43324e-05 (rank : 51)	NC score	0.332361 (rank : 47)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP5	Gene names	Hist1h2af
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-F.

H2A1H_HUMAN
θ value	1.43324e-05 (rank : 52)	NC score	0.332518 (rank : 46)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96KK5	Gene names	HIST1H2AH, HIST1H2AI
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1H_MOUSE
θ value	1.43324e-05 (rank : 53)	NC score	0.332531 (rank : 45)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP6	Gene names	Hist1h2ah
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1J_HUMAN
θ value	1.43324e-05 (rank : 54)	NC score	0.332632 (rank : 44)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q99878, Q5JXQ5	Gene names	HIST1H2AJ, H2AFE
Domain Architecture
Description	Histone H2A type 1-J.

H2A1K_MOUSE
θ value	1.43324e-05 (rank : 55)	NC score	0.332316 (rank : 48)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP7	Gene names	Hist1h2ak
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-K.

H2A1_HUMAN
θ value	1.43324e-05 (rank : 56)	NC score	0.332200 (rank : 52)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S8, P02261, Q2M1R2, Q76PA6	Gene names	HIST1H2AG, H2AFP
Domain Architecture	No domain graphic available
Description	Histone H2A type 1 (H2A.1).

H2A1_MOUSE
θ value	1.43324e-05 (rank : 57)	NC score	0.332211 (rank : 50)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P22752, P10812, Q5SZZ2	Gene names	Hist1h2ab
Domain Architecture
Description	Histone H2A type 1.

H2A2A_HUMAN
θ value	1.43324e-05 (rank : 58)	NC score	0.332016 (rank : 54)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6FI13, P20670	Gene names	HIST2H2AA3, H2AFO, HIST2H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2).

H2A2A_MOUSE
θ value	1.43324e-05 (rank : 59)	NC score	0.332016 (rank : 55)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6GSS7, P20670, Q811M3	Gene names	Hist2h2aa1
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2) (H2a-614) (H2a-615).

H2A2B_MOUSE
θ value	1.43324e-05 (rank : 60)	NC score	0.332731 (rank : 43)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64522	Gene names
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B (H2a-613A).

H2A2C_HUMAN
θ value	1.43324e-05 (rank : 61)	NC score	0.332746 (rank : 41)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q16777, Q6DRA7, Q8IUE5	Gene names	HIST2H2AC, H2AFQ
Domain Architecture
Description	Histone H2A type 2-C (H2A-GL101) (H2A/r).

H2A2C_MOUSE
θ value	1.43324e-05 (rank : 62)	NC score	0.332746 (rank : 42)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64523, Q8CGP3	Gene names	Hist2h2ac, Hist2h2ab
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-C (H2a-613B).

ARHG6_HUMAN
θ value	3.19293e-05 (rank : 63)	NC score	0.259905 (rank : 71)
Query Neighborhood Hits	281	Target Neighborhood Hits	376	Shared Neighborhood Hits	38
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FGD2_HUMAN
θ value	7.1131e-05 (rank : 64)	NC score	0.283721 (rank : 68)
Query Neighborhood Hits	281	Target Neighborhood Hits	151	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

H2AV_HUMAN
θ value	7.1131e-05 (rank : 65)	NC score	0.338028 (rank : 32)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q71UI9, Q59GV8, Q6PK98	Gene names	H2AFV, H2AV
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2AV_MOUSE
θ value	7.1131e-05 (rank : 66)	NC score	0.338028 (rank : 33)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q3THW5, Q5NC92, Q6ZWU0	Gene names	H2afv, H2av
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2AZ_HUMAN
θ value	7.1131e-05 (rank : 67)	NC score	0.338741 (rank : 30)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S5, P17317, Q6I9U0	Gene names	H2AFZ, H2AZ
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2AZ_MOUSE
θ value	7.1131e-05 (rank : 68)	NC score	0.338741 (rank : 31)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S6, P17317, Q3UA55, Q3UK43, Q68FD2	Gene names	H2afz, H2az
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

ECT2_MOUSE
θ value	0.000121331 (rank : 69)	NC score	0.294740 (rank : 67)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV2_HUMAN
θ value	0.000158464 (rank : 70)	NC score	0.238348 (rank : 79)
Query Neighborhood Hits	281	Target Neighborhood Hits	453	Shared Neighborhood Hits	45
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG6_MOUSE
θ value	0.00020696 (rank : 71)	NC score	0.243439 (rank : 76)
Query Neighborhood Hits	281	Target Neighborhood Hits	394	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

MUC1_HUMAN
θ value	0.00020696 (rank : 72)	NC score	0.056780 (rank : 175)
Query Neighborhood Hits	281	Target Neighborhood Hits	975	Shared Neighborhood Hits	66
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

ITSN1_HUMAN
θ value	0.000270298 (rank : 73)	NC score	0.155240 (rank : 109)
Query Neighborhood Hits	281	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.000270298 (rank : 74)	NC score	0.157349 (rank : 107)
Query Neighborhood Hits	281	Target Neighborhood Hits	1669	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MCF2_HUMAN
θ value	0.000461057 (rank : 75)	NC score	0.252621 (rank : 72)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	44
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NCOA6_HUMAN
θ value	0.000461057 (rank : 76)	NC score	0.088225 (rank : 122)
Query Neighborhood Hits	281	Target Neighborhood Hits	1202	Shared Neighborhood Hits	101
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NACAM_MOUSE
θ value	0.000602161 (rank : 77)	NC score	0.087363 (rank : 123)
Query Neighborhood Hits	281	Target Neighborhood Hits	1866	Shared Neighborhood Hits	134
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PER3_HUMAN
θ value	0.000786445 (rank : 78)	NC score	0.069449 (rank : 136)
Query Neighborhood Hits	281	Target Neighborhood Hits	479	Shared Neighborhood Hits	51
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

FGD1_HUMAN
θ value	0.00102713 (rank : 79)	NC score	0.276676 (rank : 69)
Query Neighborhood Hits	281	Target Neighborhood Hits	367	Shared Neighborhood Hits	73
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

H2AW_HUMAN
θ value	0.00102713 (rank : 80)	NC score	0.306746 (rank : 60)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P0M6, Q5SQT2	Gene names	H2AFY2, MACROH2A2
Domain Architecture
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

H2AW_MOUSE
θ value	0.00102713 (rank : 81)	NC score	0.306834 (rank : 59)
Query Neighborhood Hits	281	Target Neighborhood Hits	57	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CCK0, Q3TNT4, Q925I6	Gene names	H2afy2, H2afy3
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

FGD1_MOUSE
θ value	0.00134147 (rank : 82)	NC score	0.275089 (rank : 70)
Query Neighborhood Hits	281	Target Neighborhood Hits	387	Shared Neighborhood Hits	74
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

H2AY_HUMAN
θ value	0.00175202 (rank : 83)	NC score	0.297093 (rank : 65)
Query Neighborhood Hits	281	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	O75367, O75377, Q503A8, Q7Z5E3, Q96D41, Q9H8P3, Q9UP96	Gene names	H2AFY, MACROH2A1
Domain Architecture
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205).

H2AY_MOUSE
θ value	0.00175202 (rank : 84)	NC score	0.297238 (rank : 64)
Query Neighborhood Hits	281	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZQ8, Q91VZ2, Q9QZQ7	Gene names	H2afy
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y).

MLL3_MOUSE
θ value	0.00228821 (rank : 85)	NC score	0.085798 (rank : 124)
Query Neighborhood Hits	281	Target Neighborhood Hits	1399	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

NGEF_HUMAN
θ value	0.00228821 (rank : 86)	NC score	0.240136 (rank : 77)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

H2AFB_HUMAN
θ value	0.00298849 (rank : 87)	NC score	0.341902 (rank : 29)
Query Neighborhood Hits	281	Target Neighborhood Hits	36	Shared Neighborhood Hits	34
SwissProt Accessions	P98176, Q5TZB2, Q6FG78, Q96PR7	Gene names	H2AFB3, H2ABBD, H2AFB
Domain Architecture
Description	Histone H2A-Bbd (H2A Barr body-deficient) (H2A.Bbd).

MLL3_HUMAN
θ value	0.00298849 (rank : 88)	NC score	0.083983 (rank : 126)
Query Neighborhood Hits	281	Target Neighborhood Hits	1644	Shared Neighborhood Hits	108
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ANK2_HUMAN
θ value	0.00509761 (rank : 89)	NC score	0.037391 (rank : 243)
Query Neighborhood Hits	281	Target Neighborhood Hits	1615	Shared Neighborhood Hits	99
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

TRIO_HUMAN
θ value	0.00509761 (rank : 90)	NC score	0.085294 (rank : 125)
Query Neighborhood Hits	281	Target Neighborhood Hits	1580	Shared Neighborhood Hits	87
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SPTB2_HUMAN
θ value	0.00665767 (rank : 91)	NC score	0.048052 (rank : 215)
Query Neighborhood Hits	281	Target Neighborhood Hits	748	Shared Neighborhood Hits	38
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	0.00665767 (rank : 92)	NC score	0.045417 (rank : 221)
Query Neighborhood Hits	281	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SON_HUMAN
θ value	0.0113563 (rank : 93)	NC score	0.065946 (rank : 146)
Query Neighborhood Hits	281	Target Neighborhood Hits	1568	Shared Neighborhood Hits	91
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

BCL9_HUMAN
θ value	0.0148317 (rank : 94)	NC score	0.081563 (rank : 128)
Query Neighborhood Hits	281	Target Neighborhood Hits	1008	Shared Neighborhood Hits	85
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

RGS3_MOUSE
θ value	0.0193708 (rank : 95)	NC score	0.065037 (rank : 150)
Query Neighborhood Hits	281	Target Neighborhood Hits	1621	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

FGD5_HUMAN
θ value	0.0252991 (rank : 96)	NC score	0.171729 (rank : 99)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

NGEF_MOUSE
θ value	0.0330416 (rank : 97)	NC score	0.220609 (rank : 84)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

OBSCN_HUMAN
θ value	0.0330416 (rank : 98)	NC score	0.046390 (rank : 219)
Query Neighborhood Hits	281	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FGD5_MOUSE
θ value	0.0431538 (rank : 99)	NC score	0.172106 (rank : 98)
Query Neighborhood Hits	281	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

MDC1_HUMAN
θ value	0.0431538 (rank : 100)	NC score	0.070783 (rank : 133)
Query Neighborhood Hits	281	Target Neighborhood Hits	1446	Shared Neighborhood Hits	99
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

RRBP1_MOUSE
θ value	0.0431538 (rank : 101)	NC score	0.024862 (rank : 284)
Query Neighborhood Hits	281	Target Neighborhood Hits	1650	Shared Neighborhood Hits	59
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

BAZ2A_HUMAN
θ value	0.0961366 (rank : 102)	NC score	0.049657 (rank : 212)
Query Neighborhood Hits	281	Target Neighborhood Hits	780	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

GNAS1_MOUSE
θ value	0.0961366 (rank : 103)	NC score	0.025416 (rank : 282)
Query Neighborhood Hits	281	Target Neighborhood Hits	651	Shared Neighborhood Hits	49
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

BLNK_MOUSE
θ value	0.125558 (rank : 104)	NC score	0.071474 (rank : 132)
Query Neighborhood Hits	281	Target Neighborhood Hits	296	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SIG10_HUMAN
θ value	0.125558 (rank : 105)	NC score	0.017234 (rank : 312)
Query Neighborhood Hits	281	Target Neighborhood Hits	363	Shared Neighborhood Hits	15
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

SYNJ1_MOUSE
θ value	0.125558 (rank : 106)	NC score	0.056077 (rank : 179)
Query Neighborhood Hits	281	Target Neighborhood Hits	516	Shared Neighborhood Hits	73
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCGAP_HUMAN
θ value	0.125558 (rank : 107)	NC score	0.064804 (rank : 151)
Query Neighborhood Hits	281	Target Neighborhood Hits	872	Shared Neighborhood Hits	75
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DACT1_HUMAN
θ value	0.163984 (rank : 108)	NC score	0.042662 (rank : 228)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

MARK2_HUMAN
θ value	0.163984 (rank : 109)	NC score	0.003717 (rank : 365)
Query Neighborhood Hits	281	Target Neighborhood Hits	1056	Shared Neighborhood Hits	39
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

SOX13_HUMAN
θ value	0.163984 (rank : 110)	NC score	0.042017 (rank : 232)
Query Neighborhood Hits	281	Target Neighborhood Hits	464	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

CNOT4_MOUSE
θ value	0.21417 (rank : 111)	NC score	0.047229 (rank : 217)
Query Neighborhood Hits	281	Target Neighborhood Hits	277	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

FEZ1_HUMAN
θ value	0.21417 (rank : 112)	NC score	0.045289 (rank : 223)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	7
SwissProt Accessions	Q99689, O00679, O00728, Q6IBI7	Gene names	FEZ1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

PASK_HUMAN
θ value	0.21417 (rank : 113)	NC score	0.011393 (rank : 336)
Query Neighborhood Hits	281	Target Neighborhood Hits	857	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

SPTN4_HUMAN
θ value	0.21417 (rank : 114)	NC score	0.043112 (rank : 227)
Query Neighborhood Hits	281	Target Neighborhood Hits	570	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

TARA_HUMAN
θ value	0.21417 (rank : 115)	NC score	0.047743 (rank : 216)
Query Neighborhood Hits	281	Target Neighborhood Hits	1626	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

NFH_MOUSE
θ value	0.279714 (rank : 116)	NC score	0.032063 (rank : 254)
Query Neighborhood Hits	281	Target Neighborhood Hits	2247	Shared Neighborhood Hits	116
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SOX30_HUMAN
θ value	0.279714 (rank : 117)	NC score	0.033961 (rank : 247)
Query Neighborhood Hits	281	Target Neighborhood Hits	305	Shared Neighborhood Hits	30
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

SOX30_MOUSE
θ value	0.279714 (rank : 118)	NC score	0.044865 (rank : 225)
Query Neighborhood Hits	281	Target Neighborhood Hits	374	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

TARA_MOUSE
θ value	0.279714 (rank : 119)	NC score	0.056814 (rank : 174)
Query Neighborhood Hits	281	Target Neighborhood Hits	1133	Shared Neighborhood Hits	79
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ZN438_HUMAN
θ value	0.279714 (rank : 120)	NC score	0.010545 (rank : 340)
Query Neighborhood Hits	281	Target Neighborhood Hits	906	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

CAC1H_MOUSE
θ value	0.365318 (rank : 121)	NC score	0.013806 (rank : 326)
Query Neighborhood Hits	281	Target Neighborhood Hits	230	Shared Neighborhood Hits	14
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CNOT4_HUMAN
θ value	0.365318 (rank : 122)	NC score	0.043553 (rank : 226)
Query Neighborhood Hits	281	Target Neighborhood Hits	207	Shared Neighborhood Hits	12
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

JPH2_HUMAN
θ value	0.365318 (rank : 123)	NC score	0.031525 (rank : 256)
Query Neighborhood Hits	281	Target Neighborhood Hits	639	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

PCLO_HUMAN
θ value	0.365318 (rank : 124)	NC score	0.055257 (rank : 183)
Query Neighborhood Hits	281	Target Neighborhood Hits	2046	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

DAB2_MOUSE
θ value	0.47712 (rank : 125)	NC score	0.055218 (rank : 184)
Query Neighborhood Hits	281	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

ETV3_HUMAN
θ value	0.47712 (rank : 126)	NC score	0.026624 (rank : 276)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	31
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

SYNPO_HUMAN
θ value	0.47712 (rank : 127)	NC score	0.054715 (rank : 187)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

GP152_MOUSE
θ value	0.62314 (rank : 128)	NC score	0.016802 (rank : 314)
Query Neighborhood Hits	281	Target Neighborhood Hits	607	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

JADE2_MOUSE
θ value	0.62314 (rank : 129)	NC score	0.028995 (rank : 268)
Query Neighborhood Hits	281	Target Neighborhood Hits	560	Shared Neighborhood Hits	43
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

MAST4_HUMAN
θ value	0.62314 (rank : 130)	NC score	0.010274 (rank : 342)
Query Neighborhood Hits	281	Target Neighborhood Hits	1804	Shared Neighborhood Hits	78
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

RUNX2_MOUSE
θ value	0.62314 (rank : 131)	NC score	0.038640 (rank : 241)
Query Neighborhood Hits	281	Target Neighborhood Hits	119	Shared Neighborhood Hits	21
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

SEM6D_HUMAN
θ value	0.62314 (rank : 132)	NC score	0.016541 (rank : 315)
Query Neighborhood Hits	281	Target Neighborhood Hits	169	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

TACC1_MOUSE
θ value	0.62314 (rank : 133)	NC score	0.029584 (rank : 265)
Query Neighborhood Hits	281	Target Neighborhood Hits	667	Shared Neighborhood Hits	43
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TNR8_MOUSE
θ value	0.62314 (rank : 134)	NC score	0.040474 (rank : 236)
Query Neighborhood Hits	281	Target Neighborhood Hits	208	Shared Neighborhood Hits	10
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

TPM1_HUMAN
θ value	0.62314 (rank : 135)	NC score	0.028808 (rank : 269)
Query Neighborhood Hits	281	Target Neighborhood Hits	716	Shared Neighborhood Hits	31
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	0.62314 (rank : 136)	NC score	0.028492 (rank : 272)
Query Neighborhood Hits	281	Target Neighborhood Hits	729	Shared Neighborhood Hits	33
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

EPN3_HUMAN
θ value	0.813845 (rank : 137)	NC score	0.032827 (rank : 250)
Query Neighborhood Hits	281	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

NCOR2_HUMAN
θ value	0.813845 (rank : 138)	NC score	0.040386 (rank : 237)
Query Neighborhood Hits	281	Target Neighborhood Hits	870	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PASK_MOUSE
θ value	0.813845 (rank : 139)	NC score	0.008113 (rank : 352)
Query Neighborhood Hits	281	Target Neighborhood Hits	867	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PDE4A_HUMAN
θ value	0.813845 (rank : 140)	NC score	0.013169 (rank : 331)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

RC3H1_HUMAN
θ value	0.813845 (rank : 141)	NC score	0.026488 (rank : 278)
Query Neighborhood Hits	281	Target Neighborhood Hits	433	Shared Neighborhood Hits	26
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

REPS1_HUMAN
θ value	0.813845 (rank : 142)	NC score	0.042452 (rank : 229)
Query Neighborhood Hits	281	Target Neighborhood Hits	205	Shared Neighborhood Hits	26
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

TAB3_MOUSE
θ value	0.813845 (rank : 143)	NC score	0.048927 (rank : 214)
Query Neighborhood Hits	281	Target Neighborhood Hits	273	Shared Neighborhood Hits	44
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

4ET_HUMAN
θ value	1.06291 (rank : 144)	NC score	0.042230 (rank : 231)
Query Neighborhood Hits	281	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NRA8, Q8NCF2, Q9H708	Gene names	EIF4ENIF1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

CD008_HUMAN
θ value	1.06291 (rank : 145)	NC score	0.047175 (rank : 218)
Query Neighborhood Hits	281	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

RAI14_MOUSE
θ value	1.06291 (rank : 146)	NC score	0.013148 (rank : 332)
Query Neighborhood Hits	281	Target Neighborhood Hits	1505	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

S23IP_MOUSE
θ value	1.06291 (rank : 147)	NC score	0.040894 (rank : 235)
Query Neighborhood Hits	281	Target Neighborhood Hits	363	Shared Neighborhood Hits	42
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

ZN645_HUMAN
θ value	1.06291 (rank : 148)	NC score	0.055683 (rank : 181)
Query Neighborhood Hits	281	Target Neighborhood Hits	265	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

CENPF_HUMAN
θ value	1.38821 (rank : 149)	NC score	0.019884 (rank : 300)
Query Neighborhood Hits	281	Target Neighborhood Hits	1932	Shared Neighborhood Hits	62
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CJ012_HUMAN
θ value	1.38821 (rank : 150)	NC score	0.054317 (rank : 188)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

LR37A_HUMAN
θ value	1.38821 (rank : 151)	NC score	0.031295 (rank : 260)
Query Neighborhood Hits	281	Target Neighborhood Hits	720	Shared Neighborhood Hits	49
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MTR1L_HUMAN
θ value	1.38821 (rank : 152)	NC score	0.001426 (rank : 367)
Query Neighborhood Hits	281	Target Neighborhood Hits	1180	Shared Neighborhood Hits	35
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

RAI14_HUMAN
θ value	1.38821 (rank : 153)	NC score	0.014119 (rank : 324)
Query Neighborhood Hits	281	Target Neighborhood Hits	1367	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RBP2_HUMAN
θ value	1.38821 (rank : 154)	NC score	0.009440 (rank : 345)
Query Neighborhood Hits	281	Target Neighborhood Hits	249	Shared Neighborhood Hits	12
SwissProt Accessions	P49792, Q13074, Q15280, Q53TE2, Q59FH7	Gene names	RANBP2, NUP358
Domain Architecture
Description	Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270).

RUNX1_HUMAN
θ value	1.38821 (rank : 155)	NC score	0.029204 (rank : 267)
Query Neighborhood Hits	281	Target Neighborhood Hits	94	Shared Neighborhood Hits	10
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

RUNX2_HUMAN
θ value	1.38821 (rank : 156)	NC score	0.036633 (rank : 244)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	22
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

ZN688_HUMAN
θ value	1.38821 (rank : 157)	NC score	-0.002866 (rank : 373)
Query Neighborhood Hits	281	Target Neighborhood Hits	873	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

4ET_MOUSE
θ value	1.81305 (rank : 158)	NC score	0.031134 (rank : 261)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EST3, Q9CSS3	Gene names	Eif4enif1, Clast4
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

CEP68_HUMAN
θ value	1.81305 (rank : 159)	NC score	0.034213 (rank : 246)
Query Neighborhood Hits	281	Target Neighborhood Hits	128	Shared Neighborhood Hits	17
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CP51A_HUMAN
θ value	1.81305 (rank : 160)	NC score	0.011541 (rank : 335)
Query Neighborhood Hits	281	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q16850, O00770, O00772, Q16784, Q8N1A8, Q99868	Gene names	CYP51A1, CYP51
Domain Architecture
Description	Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).

GOGB1_HUMAN
θ value	1.81305 (rank : 161)	NC score	0.019068 (rank : 304)
Query Neighborhood Hits	281	Target Neighborhood Hits	2297	Shared Neighborhood Hits	71
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

HRX_HUMAN
θ value	1.81305 (rank : 162)	NC score	0.045291 (rank : 222)
Query Neighborhood Hits	281	Target Neighborhood Hits	825	Shared Neighborhood Hits	65
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

KI21A_HUMAN
θ value	1.81305 (rank : 163)	NC score	0.011066 (rank : 338)
Query Neighborhood Hits	281	Target Neighborhood Hits	1543	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

MINT_HUMAN
θ value	1.81305 (rank : 164)	NC score	0.044886 (rank : 224)
Query Neighborhood Hits	281	Target Neighborhood Hits	1291	Shared Neighborhood Hits	89
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MINT_MOUSE
θ value	1.81305 (rank : 165)	NC score	0.039556 (rank : 238)
Query Neighborhood Hits	281	Target Neighborhood Hits	1514	Shared Neighborhood Hits	81
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PRDM1_MOUSE
θ value	1.81305 (rank : 166)	NC score	-0.004216 (rank : 375)
Query Neighborhood Hits	281	Target Neighborhood Hits	766	Shared Neighborhood Hits	11
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

ADA29_HUMAN
θ value	2.36792 (rank : 167)	NC score	0.008369 (rank : 349)
Query Neighborhood Hits	281	Target Neighborhood Hits	247	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

BCL9_MOUSE
θ value	2.36792 (rank : 168)	NC score	0.066803 (rank : 143)
Query Neighborhood Hits	281	Target Neighborhood Hits	770	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BRD4_MOUSE
θ value	2.36792 (rank : 169)	NC score	0.052161 (rank : 199)
Query Neighborhood Hits	281	Target Neighborhood Hits	845	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CD248_MOUSE
θ value	2.36792 (rank : 170)	NC score	0.024498 (rank : 285)
Query Neighborhood Hits	281	Target Neighborhood Hits	578	Shared Neighborhood Hits	45
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CEND1_MOUSE
θ value	2.36792 (rank : 171)	NC score	0.018460 (rank : 307)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CI061_HUMAN
θ value	2.36792 (rank : 172)	NC score	0.021072 (rank : 298)
Query Neighborhood Hits	281	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q15884, Q5T6C8, Q5T6C9, Q96N10	Gene names	C9orf61, X123
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf61 (Protein X123).

CPXM2_HUMAN
θ value	2.36792 (rank : 173)	NC score	0.006250 (rank : 361)
Query Neighborhood Hits	281	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N436	Gene names	CPXM2
Domain Architecture
Description	Carboxypeptidase-like protein X2 precursor.

EP15_HUMAN
θ value	2.36792 (rank : 174)	NC score	0.031366 (rank : 259)
Query Neighborhood Hits	281	Target Neighborhood Hits	1021	Shared Neighborhood Hits	50
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FYB_MOUSE
θ value	2.36792 (rank : 175)	NC score	0.039198 (rank : 239)
Query Neighborhood Hits	281	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

LARP4_MOUSE
θ value	2.36792 (rank : 176)	NC score	0.030967 (rank : 263)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

NCOA6_MOUSE
θ value	2.36792 (rank : 177)	NC score	0.075043 (rank : 130)
Query Neighborhood Hits	281	Target Neighborhood Hits	1076	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NDUB7_MOUSE
θ value	2.36792 (rank : 178)	NC score	0.025436 (rank : 281)
Query Neighborhood Hits	281	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CR61	Gene names	Ndufb7
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase B18 subunit) (Complex I-B18) (CI-B18).

REPS1_MOUSE
θ value	2.36792 (rank : 179)	NC score	0.049005 (rank : 213)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	28
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

SPTN2_HUMAN
θ value	2.36792 (rank : 180)	NC score	0.032533 (rank : 252)
Query Neighborhood Hits	281	Target Neighborhood Hits	535	Shared Neighborhood Hits	30
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

ZIMP7_MOUSE
θ value	2.36792 (rank : 181)	NC score	0.040917 (rank : 234)
Query Neighborhood Hits	281	Target Neighborhood Hits	566	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

CCD39_HUMAN
θ value	3.0926 (rank : 182)	NC score	0.017176 (rank : 313)
Query Neighborhood Hits	281	Target Neighborhood Hits	868	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CRIS2_MOUSE
θ value	3.0926 (rank : 183)	NC score	0.021438 (rank : 297)
Query Neighborhood Hits	281	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P16563	Gene names	Crisp2, Tpx-1, Tpx1
Domain Architecture
Description	Cysteine-rich secretory protein 2 precursor (CRISP-2) (Testis-specific protein TPX-1).

PHF12_MOUSE
θ value	3.0926 (rank : 184)	NC score	0.019330 (rank : 302)
Query Neighborhood Hits	281	Target Neighborhood Hits	172	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PO6F2_MOUSE
θ value	3.0926 (rank : 185)	NC score	0.019060 (rank : 305)
Query Neighborhood Hits	281	Target Neighborhood Hits	639	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

SRRM1_HUMAN
θ value	3.0926 (rank : 186)	NC score	0.083830 (rank : 127)
Query Neighborhood Hits	281	Target Neighborhood Hits	690	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ZIM10_HUMAN
θ value	3.0926 (rank : 187)	NC score	0.031395 (rank : 258)
Query Neighborhood Hits	281	Target Neighborhood Hits	577	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

BIM_MOUSE
θ value	4.03905 (rank : 188)	NC score	0.041580 (rank : 233)
Query Neighborhood Hits	281	Target Neighborhood Hits	124	Shared Neighborhood Hits	12
SwissProt Accessions	O54918, O54919, O54920	Gene names	Bcl2l11, Bim
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

CD248_HUMAN
θ value	4.03905 (rank : 189)	NC score	0.028514 (rank : 271)
Query Neighborhood Hits	281	Target Neighborhood Hits	679	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

EHMT2_MOUSE
θ value	4.03905 (rank : 190)	NC score	0.014132 (rank : 323)
Query Neighborhood Hits	281	Target Neighborhood Hits	750	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GAK5_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.008896 (rank : 346)
Query Neighborhood Hits	281	Target Neighborhood Hits	429	Shared Neighborhood Hits	30
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

KI21A_MOUSE
θ value	4.03905 (rank : 192)	NC score	0.010218 (rank : 343)
Query Neighborhood Hits	281	Target Neighborhood Hits	1317	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

LRCH1_MOUSE
θ value	4.03905 (rank : 193)	NC score	0.021847 (rank : 294)
Query Neighborhood Hits	281	Target Neighborhood Hits	264	Shared Neighborhood Hits	15
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

MYBB_MOUSE
θ value	4.03905 (rank : 194)	NC score	0.013281 (rank : 329)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	P48972	Gene names	Mybl2, Bmyb
Domain Architecture
Description	Myb-related protein B (B-Myb).

MYST3_HUMAN
θ value	4.03905 (rank : 195)	NC score	0.027617 (rank : 273)
Query Neighborhood Hits	281	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

NELL1_HUMAN
θ value	4.03905 (rank : 196)	NC score	0.000069 (rank : 369)
Query Neighborhood Hits	281	Target Neighborhood Hits	451	Shared Neighborhood Hits	10
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NFAC2_MOUSE
θ value	4.03905 (rank : 197)	NC score	0.013362 (rank : 328)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q60591, Q60984, Q60985	Gene names	Nfatc2, Nfat1, Nfatp
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

NUP53_HUMAN
θ value	4.03905 (rank : 198)	NC score	0.033252 (rank : 249)
Query Neighborhood Hits	281	Target Neighborhood Hits	156	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

RUNX1_MOUSE
θ value	4.03905 (rank : 199)	NC score	0.026653 (rank : 275)
Query Neighborhood Hits	281	Target Neighborhood Hits	93	Shared Neighborhood Hits	13
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

SPTN5_HUMAN
θ value	4.03905 (rank : 200)	NC score	0.028599 (rank : 270)
Query Neighborhood Hits	281	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SRRM2_MOUSE
θ value	4.03905 (rank : 201)	NC score	0.058378 (rank : 168)
Query Neighborhood Hits	281	Target Neighborhood Hits	1470	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TIF1G_MOUSE
θ value	4.03905 (rank : 202)	NC score	0.021606 (rank : 296)
Query Neighborhood Hits	281	Target Neighborhood Hits	498	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

UBP42_HUMAN
θ value	4.03905 (rank : 203)	NC score	0.016279 (rank : 318)
Query Neighborhood Hits	281	Target Neighborhood Hits	445	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UBP53_MOUSE
θ value	4.03905 (rank : 204)	NC score	0.017344 (rank : 311)
Query Neighborhood Hits	281	Target Neighborhood Hits	188	Shared Neighborhood Hits	13
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

ADA10_MOUSE
θ value	5.27518 (rank : 205)	NC score	0.007697 (rank : 353)
Query Neighborhood Hits	281	Target Neighborhood Hits	194	Shared Neighborhood Hits	6
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

BIM_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.035045 (rank : 245)
Query Neighborhood Hits	281	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	O43521, O43522	Gene names	BCL2L11, BIM
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

C2TA_HUMAN
θ value	5.27518 (rank : 207)	NC score	0.026382 (rank : 279)
Query Neighborhood Hits	281	Target Neighborhood Hits	190	Shared Neighborhood Hits	22
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_MOUSE
θ value	5.27518 (rank : 208)	NC score	0.018741 (rank : 306)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CAC1G_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.016186 (rank : 319)
Query Neighborhood Hits	281	Target Neighborhood Hits	587	Shared Neighborhood Hits	43
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

COG3_HUMAN
θ value	5.27518 (rank : 210)	NC score	0.012896 (rank : 334)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

EXOC6_MOUSE
θ value	5.27518 (rank : 211)	NC score	0.014283 (rank : 320)
Query Neighborhood Hits	281	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R313	Gene names	Exoc6, Sec15a, Sec15l1
Domain Architecture
Description	Exocyst complex component 6 (Exocyst complex component Sec15A) (Sec15- like 1).

FA47A_HUMAN
θ value	5.27518 (rank : 212)	NC score	0.038740 (rank : 240)
Query Neighborhood Hits	281	Target Neighborhood Hits	451	Shared Neighborhood Hits	42
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GRIP2_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.008559 (rank : 348)
Query Neighborhood Hits	281	Target Neighborhood Hits	256	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

JPH1_MOUSE
θ value	5.27518 (rank : 214)	NC score	0.020864 (rank : 299)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

MYO15_HUMAN
θ value	5.27518 (rank : 215)	NC score	0.018395 (rank : 308)
Query Neighborhood Hits	281	Target Neighborhood Hits	671	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NCOA2_MOUSE
θ value	5.27518 (rank : 216)	NC score	0.013892 (rank : 325)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	26
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NOP14_HUMAN
θ value	5.27518 (rank : 217)	NC score	0.016338 (rank : 317)
Query Neighborhood Hits	281	Target Neighborhood Hits	573	Shared Neighborhood Hits	30
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

PHF3_HUMAN
θ value	5.27518 (rank : 218)	NC score	0.014255 (rank : 321)
Query Neighborhood Hits	281	Target Neighborhood Hits	419	Shared Neighborhood Hits	21
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

PRG4_MOUSE
θ value	5.27518 (rank : 219)	NC score	0.060484 (rank : 161)
Query Neighborhood Hits	281	Target Neighborhood Hits	624	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PTPRG_MOUSE
θ value	5.27518 (rank : 220)	NC score	0.003630 (rank : 366)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	17
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

SCMH1_HUMAN
θ value	5.27518 (rank : 221)	NC score	0.017575 (rank : 309)
Query Neighborhood Hits	281	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	Q96GD3, Q5VT76, Q6IAJ4, Q8WU48, Q9UKM5, Q9UKM6	Gene names	SCMH1
Domain Architecture	No domain graphic available
Description	Polycomb protein SCMH1 (Sex comb on midleg homolog 1).

SCMH1_MOUSE
θ value	5.27518 (rank : 222)	NC score	0.019227 (rank : 303)
Query Neighborhood Hits	281	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K214, Q9JME0	Gene names	Scmh1
Domain Architecture	No domain graphic available
Description	Polycomb protein SCMH1 (Sex comb on midleg homolog 1).

SEM6D_MOUSE
θ value	5.27518 (rank : 223)	NC score	0.011253 (rank : 337)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0	Gene names	Sema6d, Kiaa1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SETX_HUMAN
θ value	5.27518 (rank : 224)	NC score	0.022892 (rank : 291)
Query Neighborhood Hits	281	Target Neighborhood Hits	368	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SPR1B_MOUSE
θ value	5.27518 (rank : 225)	NC score	0.024295 (rank : 287)
Query Neighborhood Hits	281	Target Neighborhood Hits	395	Shared Neighborhood Hits	36
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SPT5H_HUMAN
θ value	5.27518 (rank : 226)	NC score	0.031513 (rank : 257)
Query Neighborhood Hits	281	Target Neighborhood Hits	436	Shared Neighborhood Hits	43
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	5.27518 (rank : 227)	NC score	0.031681 (rank : 255)
Query Neighborhood Hits	281	Target Neighborhood Hits	437	Shared Neighborhood Hits	44
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

ALMS1_MOUSE
θ value	6.88961 (rank : 228)	NC score	0.012920 (rank : 333)
Query Neighborhood Hits	281	Target Neighborhood Hits	181	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

ATX2_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.045944 (rank : 220)
Query Neighborhood Hits	281	Target Neighborhood Hits	375	Shared Neighborhood Hits	55
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

ATX2_MOUSE
θ value	6.88961 (rank : 230)	NC score	0.051791 (rank : 201)
Query Neighborhood Hits	281	Target Neighborhood Hits	445	Shared Neighborhood Hits	64
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

CSKI2_MOUSE
θ value	6.88961 (rank : 231)	NC score	0.021679 (rank : 295)
Query Neighborhood Hits	281	Target Neighborhood Hits	812	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSPG3_HUMAN
θ value	6.88961 (rank : 232)	NC score	0.006990 (rank : 356)
Query Neighborhood Hits	281	Target Neighborhood Hits	676	Shared Neighborhood Hits	36
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

DLX4_MOUSE
θ value	6.88961 (rank : 233)	NC score	-0.001465 (rank : 370)
Query Neighborhood Hits	281	Target Neighborhood Hits	352	Shared Neighborhood Hits	7
SwissProt Accessions	P70436, Q3UM51, Q8R4I3	Gene names	Dlx4, Dlx7
Domain Architecture
Description	Homeobox protein DLX-4 (DLX-7).

K1683_HUMAN
θ value	6.88961 (rank : 234)	NC score	0.029511 (rank : 266)
Query Neighborhood Hits	281	Target Neighborhood Hits	240	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

KSR1_HUMAN
θ value	6.88961 (rank : 235)	NC score	-0.001510 (rank : 371)
Query Neighborhood Hits	281	Target Neighborhood Hits	867	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	6.88961 (rank : 236)	NC score	-0.001594 (rank : 372)
Query Neighborhood Hits	281	Target Neighborhood Hits	870	Shared Neighborhood Hits	17
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LPP_HUMAN
θ value	6.88961 (rank : 237)	NC score	0.019418 (rank : 301)
Query Neighborhood Hits	281	Target Neighborhood Hits	775	Shared Neighborhood Hits	55
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MACF1_HUMAN
θ value	6.88961 (rank : 238)	NC score	0.021866 (rank : 293)
Query Neighborhood Hits	281	Target Neighborhood Hits	1341	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	6.88961 (rank : 239)	NC score	0.023108 (rank : 290)
Query Neighborhood Hits	281	Target Neighborhood Hits	1321	Shared Neighborhood Hits	57
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MAGE1_HUMAN
θ value	6.88961 (rank : 240)	NC score	0.030848 (rank : 264)
Query Neighborhood Hits	281	Target Neighborhood Hits	1389	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAP1B_HUMAN
θ value	6.88961 (rank : 241)	NC score	0.026577 (rank : 277)
Query Neighborhood Hits	281	Target Neighborhood Hits	903	Shared Neighborhood Hits	62
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MOR2B_MOUSE
θ value	6.88961 (rank : 242)	NC score	0.008671 (rank : 347)
Query Neighborhood Hits	281	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C5W4, Q8CG24	Gene names	Morc2b, Tce6
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2B (TCE6).

MYOD1_HUMAN
θ value	6.88961 (rank : 243)	NC score	0.008260 (rank : 350)
Query Neighborhood Hits	281	Target Neighborhood Hits	100	Shared Neighborhood Hits	6
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

PLD2_HUMAN
θ value	6.88961 (rank : 244)	NC score	0.011029 (rank : 339)
Query Neighborhood Hits	281	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	O14939, O43540, O43579, O43580, Q96BY3	Gene names	PLD2
Domain Architecture
Description	Phospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2).

SETBP_HUMAN
θ value	6.88961 (rank : 245)	NC score	0.027610 (rank : 274)
Query Neighborhood Hits	281	Target Neighborhood Hits	305	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SFPQ_MOUSE
θ value	6.88961 (rank : 246)	NC score	0.042383 (rank : 230)
Query Neighborhood Hits	281	Target Neighborhood Hits	958	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SMAL1_HUMAN
θ value	6.88961 (rank : 247)	NC score	0.010367 (rank : 341)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

TACC2_HUMAN
θ value	6.88961 (rank : 248)	NC score	0.032688 (rank : 251)
Query Neighborhood Hits	281	Target Neighborhood Hits	856	Shared Neighborhood Hits	63
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TAU_HUMAN
θ value	6.88961 (rank : 249)	NC score	0.033438 (rank : 248)
Query Neighborhood Hits	281	Target Neighborhood Hits	448	Shared Neighborhood Hits	49
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TPM3_HUMAN
θ value	6.88961 (rank : 250)	NC score	0.024324 (rank : 286)
Query Neighborhood Hits	281	Target Neighborhood Hits	689	Shared Neighborhood Hits	32
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
θ value	6.88961 (rank : 251)	NC score	0.023680 (rank : 288)
Query Neighborhood Hits	281	Target Neighborhood Hits	676	Shared Neighborhood Hits	31
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

TRI66_HUMAN
θ value	6.88961 (rank : 252)	NC score	0.023471 (rank : 289)
Query Neighborhood Hits	281	Target Neighborhood Hits	479	Shared Neighborhood Hits	38
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

UBQL4_MOUSE
θ value	6.88961 (rank : 253)	NC score	0.010148 (rank : 344)
Query Neighborhood Hits	281	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

AMFR2_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.006937 (rank : 357)
Query Neighborhood Hits	281	Target Neighborhood Hits	219	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

APLP1_MOUSE
θ value	8.99809 (rank : 255)	NC score	0.014220 (rank : 322)
Query Neighborhood Hits	281	Target Neighborhood Hits	130	Shared Neighborhood Hits	12
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

CECR2_HUMAN
θ value	8.99809 (rank : 256)	NC score	0.026314 (rank : 280)
Query Neighborhood Hits	281	Target Neighborhood Hits	543	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CLCN1_HUMAN
θ value	8.99809 (rank : 257)	NC score	0.004401 (rank : 364)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	12
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

ERRFI_MOUSE
θ value	8.99809 (rank : 258)	NC score	0.017413 (rank : 310)
Query Neighborhood Hits	281	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

FYCO1_MOUSE
θ value	8.99809 (rank : 259)	NC score	0.025310 (rank : 283)
Query Neighborhood Hits	281	Target Neighborhood Hits	1059	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GDF11_HUMAN
θ value	8.99809 (rank : 260)	NC score	0.006575 (rank : 359)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	O95390, Q9UID1, Q9UID2	Gene names	GDF11, BMP11
Domain Architecture
Description	Growth/differentiation factor 11 precursor (GDF-11) (Bone morphogenetic protein 11).

GDF11_MOUSE
θ value	8.99809 (rank : 261)	NC score	0.006574 (rank : 360)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1W4, Q9QX55, Q9R221	Gene names	Gdf11, Bmp11
Domain Architecture
Description	Growth/differentiation factor 11 precursor (GDF-11) (Bone morphogenetic protein 11).

HCLS1_MOUSE
θ value	8.99809 (rank : 262)	NC score	0.063012 (rank : 156)
Query Neighborhood Hits	281	Target Neighborhood Hits	329	Shared Neighborhood Hits	48
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

K1802_MOUSE
θ value	8.99809 (rank : 263)	NC score	0.031116 (rank : 262)
Query Neighborhood Hits	281	Target Neighborhood Hits	1596	Shared Neighborhood Hits	92
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

M4K4_MOUSE
θ value	8.99809 (rank : 264)	NC score	0.000548 (rank : 368)
Query Neighborhood Hits	281	Target Neighborhood Hits	1560	Shared Neighborhood Hits	45
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MDC1_MOUSE
θ value	8.99809 (rank : 265)	NC score	0.059038 (rank : 165)
Query Neighborhood Hits	281	Target Neighborhood Hits	998	Shared Neighborhood Hits	90
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MUG1_MOUSE
θ value	8.99809 (rank : 266)	NC score	0.005273 (rank : 362)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P28665	Gene names	Mug1, Mug-1
Domain Architecture
Description	Murinoglobulin-1 precursor (MuG1).

MYO9B_HUMAN
θ value	8.99809 (rank : 267)	NC score	0.007564 (rank : 355)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	41
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYOM1_MOUSE
θ value	8.99809 (rank : 268)	NC score	0.006739 (rank : 358)
Query Neighborhood Hits	281	Target Neighborhood Hits	415	Shared Neighborhood Hits	18
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

NAF1_HUMAN
θ value	8.99809 (rank : 269)	NC score	0.013620 (rank : 327)
Query Neighborhood Hits	281	Target Neighborhood Hits	937	Shared Neighborhood Hits	40
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NDF1_MOUSE
θ value	8.99809 (rank : 270)	NC score	0.007645 (rank : 354)
Query Neighborhood Hits	281	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NUP53_MOUSE
θ value	8.99809 (rank : 271)	NC score	0.022513 (rank : 292)
Query Neighborhood Hits	281	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

OSBL9_HUMAN
θ value	8.99809 (rank : 272)	NC score	0.032128 (rank : 253)
Query Neighborhood Hits	281	Target Neighborhood Hits	138	Shared Neighborhood Hits	19
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PTN4_HUMAN
θ value	8.99809 (rank : 273)	NC score	0.016421 (rank : 316)
Query Neighborhood Hits	281	Target Neighborhood Hits	303	Shared Neighborhood Hits	13
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

REN3B_HUMAN
θ value	8.99809 (rank : 274)	NC score	0.013209 (rank : 330)
Query Neighborhood Hits	281	Target Neighborhood Hits	412	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

RIPK5_MOUSE
θ value	8.99809 (rank : 275)	NC score	-0.002889 (rank : 374)
Query Neighborhood Hits	281	Target Neighborhood Hits	874	Shared Neighborhood Hits	16
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

SEM4D_MOUSE
θ value	8.99809 (rank : 276)	NC score	0.004724 (rank : 363)
Query Neighborhood Hits	281	Target Neighborhood Hits	143	Shared Neighborhood Hits	7
SwissProt Accessions	O09126	Gene names	Sema4d, Semacl2, Semaj
Domain Architecture
Description	Semaphorin-4D precursor (Semaphorin J) (Sema J) (Semaphorin C-like 2) (M-Sema G).

SPEG_HUMAN
θ value	8.99809 (rank : 277)	NC score	0.008229 (rank : 351)
Query Neighborhood Hits	281	Target Neighborhood Hits	1762	Shared Neighborhood Hits	84
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TACC2_MOUSE
θ value	8.99809 (rank : 278)	NC score	0.038151 (rank : 242)
Query Neighborhood Hits	281	Target Neighborhood Hits	774	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

UFO_HUMAN
θ value	8.99809 (rank : 279)	NC score	-0.004871 (rank : 376)
Query Neighborhood Hits	281	Target Neighborhood Hits	981	Shared Neighborhood Hits	15
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

WBP11_HUMAN
θ value	8.99809 (rank : 280)	NC score	0.058319 (rank : 169)
Query Neighborhood Hits	281	Target Neighborhood Hits	354	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	8.99809 (rank : 281)	NC score	0.056441 (rank : 178)
Query Neighborhood Hits	281	Target Neighborhood Hits	362	Shared Neighborhood Hits	55
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

ABI2_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.058450 (rank : 167)
Query Neighborhood Hits	281	Target Neighborhood Hits	350	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABR_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.140463 (rank : 112)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	38
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.123681 (rank : 116)
Query Neighborhood Hits	281	Target Neighborhood Hits	176	Shared Neighborhood Hits	30
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.099802 (rank : 121)
Query Neighborhood Hits	281	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.108482 (rank : 119)
Query Neighborhood Hits	281	Target Neighborhood Hits	142	Shared Neighborhood Hits	35
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.121517 (rank : 118)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	35
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.186970 (rank : 90)
Query Neighborhood Hits	281	Target Neighborhood Hits	82	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.186637 (rank : 91)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	33
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.183915 (rank : 94)
Query Neighborhood Hits	281	Target Neighborhood Hits	172	Shared Neighborhood Hits	38
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.171295 (rank : 100)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.168282 (rank : 103)
Query Neighborhood Hits	281	Target Neighborhood Hits	79	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.197867 (rank : 87)
Query Neighborhood Hits	281	Target Neighborhood Hits	187	Shared Neighborhood Hits	42
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.201715 (rank : 86)
Query Neighborhood Hits	281	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.157973 (rank : 106)
Query Neighborhood Hits	281	Target Neighborhood Hits	375	Shared Neighborhood Hits	51
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.136235 (rank : 113)
Query Neighborhood Hits	281	Target Neighborhood Hits	351	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.131502 (rank : 115)
Query Neighborhood Hits	281	Target Neighborhood Hits	344	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.170006 (rank : 102)
Query Neighborhood Hits	281	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.179851 (rank : 96)
Query Neighborhood Hits	281	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.178965 (rank : 97)
Query Neighborhood Hits	281	Target Neighborhood Hits	152	Shared Neighborhood Hits	39
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ATN1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.050159 (rank : 211)
Query Neighborhood Hits	281	Target Neighborhood Hits	676	Shared Neighborhood Hits	80
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BCR_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.141167 (rank : 111)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	43
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CD2AP_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.063347 (rank : 155)
Query Neighborhood Hits	281	Target Neighborhood Hits	315	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.062750 (rank : 157)
Query Neighborhood Hits	281	Target Neighborhood Hits	336	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CS016_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.056630 (rank : 177)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	49
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

CT152_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.067736 (rank : 141)
Query Neighborhood Hits	281	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.053633 (rank : 192)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

DNMBP_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.155399 (rank : 108)
Query Neighborhood Hits	281	Target Neighborhood Hits	413	Shared Neighborhood Hits	48
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.171045 (rank : 101)
Query Neighborhood Hits	281	Target Neighborhood Hits	435	Shared Neighborhood Hits	55
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DRAP1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.057586 (rank : 172)
Query Neighborhood Hits	281	Target Neighborhood Hits	51	Shared Neighborhood Hits	26
SwissProt Accessions	Q14919, Q13448	Gene names	DRAP1
Domain Architecture	No domain graphic available
Description	Dr1-associated corepressor (Dr1-associated protein 1) (Negative co- factor 2 alpha) (NC2 alpha).

DRAP1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.054859 (rank : 186)
Query Neighborhood Hits	281	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D6N5	Gene names	Drap1
Domain Architecture	No domain graphic available
Description	Dr1-associated corepressor (Dr1-associated protein 1) (Negative co- factor 2 alpha) (NC2 alpha).

DUET_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.069201 (rank : 137)
Query Neighborhood Hits	281	Target Neighborhood Hits	1220	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ENAH_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.051210 (rank : 203)
Query Neighborhood Hits	281	Target Neighborhood Hits	919	Shared Neighborhood Hits	87
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

FARP1_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.160748 (rank : 105)
Query Neighborhood Hits	281	Target Neighborhood Hits	241	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FGD2_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.244746 (rank : 75)
Query Neighborhood Hits	281	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD6_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.191952 (rank : 89)
Query Neighborhood Hits	281	Target Neighborhood Hits	237	Shared Neighborhood Hits	41
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.202411 (rank : 85)
Query Neighborhood Hits	281	Target Neighborhood Hits	282	Shared Neighborhood Hits	61
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GP155_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.054047 (rank : 190)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

GRAP2_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.052354 (rank : 197)
Query Neighborhood Hits	281	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.051906 (rank : 200)
Query Neighborhood Hits	281	Target Neighborhood Hits	297	Shared Neighborhood Hits	17
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.055535 (rank : 182)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.054971 (rank : 185)
Query Neighborhood Hits	281	Target Neighborhood Hits	309	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GSCR1_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.069157 (rank : 138)
Query Neighborhood Hits	281	Target Neighborhood Hits	674	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HAPIP_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.183839 (rank : 95)
Query Neighborhood Hits	281	Target Neighborhood Hits	350	Shared Neighborhood Hits	46
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCLS1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.064508 (rank : 152)
Query Neighborhood Hits	281	Target Neighborhood Hits	358	Shared Neighborhood Hits	36
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ITSN2_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.142238 (rank : 110)
Query Neighborhood Hits	281	Target Neighborhood Hits	1173	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.134493 (rank : 114)
Query Neighborhood Hits	281	Target Neighborhood Hits	1371	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.104018 (rank : 120)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	26
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MBD6_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.058174 (rank : 170)
Query Neighborhood Hits	281	Target Neighborhood Hits	349	Shared Neighborhood Hits	57
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MCF2L_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.194264 (rank : 88)
Query Neighborhood Hits	281	Target Neighborhood Hits	255	Shared Neighborhood Hits	48
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MILK1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.052532 (rank : 196)
Query Neighborhood Hits	281	Target Neighborhood Hits	788	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MLL2_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.065228 (rank : 149)
Query Neighborhood Hits	281	Target Neighborhood Hits	1788	Shared Neighborhood Hits	132
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MUC1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.050892 (rank : 205)
Query Neighborhood Hits	281	Target Neighborhood Hits	388	Shared Neighborhood Hits	41
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MUC7_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.077399 (rank : 129)
Query Neighborhood Hits	281	Target Neighborhood Hits	538	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCF1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.067033 (rank : 142)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.059705 (rank : 164)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.056716 (rank : 176)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.056964 (rank : 173)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.050500 (rank : 209)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PKHA6_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.051059 (rank : 204)
Query Neighborhood Hits	281	Target Neighborhood Hits	591	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.065969 (rank : 145)
Query Neighborhood Hits	281	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.064195 (rank : 153)
Query Neighborhood Hits	281	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.069800 (rank : 134)
Query Neighborhood Hits	281	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.069791 (rank : 135)
Query Neighborhood Hits	281	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHG4_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.167517 (rank : 104)
Query Neighborhood Hits	281	Target Neighborhood Hits	200	Shared Neighborhood Hits	38
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PRB3_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.052660 (rank : 195)
Query Neighborhood Hits	281	Target Neighborhood Hits	318	Shared Neighborhood Hits	50
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.050791 (rank : 206)
Query Neighborhood Hits	281	Target Neighborhood Hits	330	Shared Neighborhood Hits	51
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRG4_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.068176 (rank : 140)
Query Neighborhood Hits	281	Target Neighborhood Hits	764	Shared Neighborhood Hits	92
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.066545 (rank : 144)
Query Neighborhood Hits	281	Target Neighborhood Hits	385	Shared Neighborhood Hits	58
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.062175 (rank : 159)
Query Neighborhood Hits	281	Target Neighborhood Hits	347	Shared Neighborhood Hits	55
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRR12_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.059966 (rank : 163)
Query Neighborhood Hits	281	Target Neighborhood Hits	460	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RAPH1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.065745 (rank : 148)
Query Neighborhood Hits	281	Target Neighborhood Hits	593	Shared Neighborhood Hits	94
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RERE_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.053050 (rank : 193)
Query Neighborhood Hits	281	Target Neighborhood Hits	785	Shared Neighborhood Hits	88
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.121584 (rank : 117)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	55
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SH3K1_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.068215 (rank : 139)
Query Neighborhood Hits	281	Target Neighborhood Hits	341	Shared Neighborhood Hits	33
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.063698 (rank : 154)
Query Neighborhood Hits	281	Target Neighborhood Hits	332	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.052847 (rank : 194)
Query Neighborhood Hits	281	Target Neighborhood Hits	1041	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SRBS1_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.057845 (rank : 171)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.053860 (rank : 191)
Query Neighborhood Hits	281	Target Neighborhood Hits	409	Shared Neighborhood Hits	36
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRRM1_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.065842 (rank : 147)
Query Neighborhood Hits	281	Target Neighborhood Hits	966	Shared Neighborhood Hits	92
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.058493 (rank : 166)
Query Neighborhood Hits	281	Target Neighborhood Hits	1296	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STAC3_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.050664 (rank : 208)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.051546 (rank : 202)
Query Neighborhood Hits	281	Target Neighborhood Hits	232	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.062720 (rank : 158)
Query Neighborhood Hits	281	Target Neighborhood Hits	276	Shared Neighborhood Hits	20
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.060338 (rank : 162)
Query Neighborhood Hits	281	Target Neighborhood Hits	268	Shared Neighborhood Hits	20
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TARSH_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.050716 (rank : 207)
Query Neighborhood Hits	281	Target Neighborhood Hits	768	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TIAM1_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.230192 (rank : 81)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.227009 (rank : 82)
Query Neighborhood Hits	281	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.185539 (rank : 92)
Query Neighborhood Hits	281	Target Neighborhood Hits	452	Shared Neighborhood Hits	41
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.184590 (rank : 93)
Query Neighborhood Hits	281	Target Neighborhood Hits	430	Shared Neighborhood Hits	40
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WASIP_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.071544 (rank : 131)
Query Neighborhood Hits	281	Target Neighborhood Hits	458	Shared Neighborhood Hits	73
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.061538 (rank : 160)
Query Neighborhood Hits	281	Target Neighborhood Hits	392	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WIRE_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.055941 (rank : 180)
Query Neighborhood Hits	281	Target Neighborhood Hits	329	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.052343 (rank : 198)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	52
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

YLPM1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.054074 (rank : 189)
Query Neighborhood Hits	281	Target Neighborhood Hits	505	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZN207_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.050170 (rank : 210)
Query Neighborhood Hits	281	Target Neighborhood Hits	326	Shared Neighborhood Hits	35
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

Hits sorted by NC score

SOS1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	281
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.990321 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	281	Target Neighborhood Hits	274	Shared Neighborhood Hits	229
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
NC score	0.960617 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	281	Target Neighborhood Hits	193	Shared Neighborhood Hits	115
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

RPGF1_HUMAN
NC score	0.669574 (rank : 4)	θ value	1.98606e-31 (rank : 6)
Query Neighborhood Hits	281	Target Neighborhood Hits	262	Shared Neighborhood Hits	37
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GNRP_MOUSE
NC score	0.664183 (rank : 5)	θ value	4.13158e-37 (rank : 4)
Query Neighborhood Hits	281	Target Neighborhood Hits	191	Shared Neighborhood Hits	58
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
NC score	0.648322 (rank : 6)	θ value	1.20211e-36 (rank : 5)
Query Neighborhood Hits	281	Target Neighborhood Hits	239	Shared Neighborhood Hits	56
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RGL1_HUMAN
NC score	0.609755 (rank : 7)	θ value	1.12775e-26 (rank : 7)
Query Neighborhood Hits	281	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
NC score	0.593599 (rank : 8)	θ value	8.08199e-25 (rank : 8)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	23
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_HUMAN
NC score	0.577904 (rank : 9)	θ value	2.97466e-19 (rank : 11)
Query Neighborhood Hits	281	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
NC score	0.562678 (rank : 10)	θ value	8.95645e-16 (rank : 17)
Query Neighborhood Hits	281	Target Neighborhood Hits	51	Shared Neighborhood Hits	26
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_MOUSE
NC score	0.555893 (rank : 11)	θ value	3.40345e-15 (rank : 18)
Query Neighborhood Hits	281	Target Neighborhood Hits	115	Shared Neighborhood Hits	45
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RPGF5_HUMAN
NC score	0.554013 (rank : 12)	θ value	1.80466e-16 (rank : 15)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

GNDS_HUMAN
NC score	0.553754 (rank : 13)	θ value	8.10077e-17 (rank : 14)
Query Neighborhood Hits	281	Target Neighborhood Hits	201	Shared Neighborhood Hits	52
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGDSR_HUMAN
NC score	0.551250 (rank : 14)	θ value	3.18553e-13 (rank : 23)
Query Neighborhood Hits	281	Target Neighborhood Hits	63	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF5_MOUSE
NC score	0.548563 (rank : 15)	θ value	9.56915e-18 (rank : 12)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.524112 (rank : 16)	θ value	1.5773e-20 (rank : 9)
Query Neighborhood Hits	281	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.520960 (rank : 17)	θ value	5.99374e-20 (rank : 10)
Query Neighborhood Hits	281	Target Neighborhood Hits	80	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF2_HUMAN
NC score	0.503759 (rank : 18)	θ value	2.13179e-17 (rank : 13)
Query Neighborhood Hits	281	Target Neighborhood Hits	242	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

GRP3_HUMAN
NC score	0.485812 (rank : 19)	θ value	1.29331e-14 (rank : 20)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF6_HUMAN
NC score	0.482520 (rank : 20)	θ value	1.80466e-16 (rank : 16)
Query Neighborhood Hits	281	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF3_HUMAN
NC score	0.479933 (rank : 21)	θ value	1.2105e-12 (rank : 26)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.458177 (rank : 22)	θ value	2.98157e-11 (rank : 27)
Query Neighborhood Hits	281	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
NC score	0.408991 (rank : 23)	θ value	5.8054e-15 (rank : 19)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG9_MOUSE
NC score	0.378979 (rank : 24)	θ value	1.68911e-14 (rank : 21)
Query Neighborhood Hits	281	Target Neighborhood Hits	234	Shared Neighborhood Hits	39
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.378399 (rank : 25)	θ value	2.20605e-14 (rank : 22)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	39
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG4_MOUSE
NC score	0.375029 (rank : 26)	θ value	9.26847e-13 (rank : 25)
Query Neighborhood Hits	281	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.367449 (rank : 27)	θ value	5.43371e-13 (rank : 24)
Query Neighborhood Hits	281	Target Neighborhood Hits	242	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.353841 (rank : 28)	θ value	1.9326e-10 (rank : 28)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

H2AFB_HUMAN
NC score	0.341902 (rank : 29)	θ value	0.00298849 (rank : 87)
Query Neighborhood Hits	281	Target Neighborhood Hits	36	Shared Neighborhood Hits	34
SwissProt Accessions	P98176, Q5TZB2, Q6FG78, Q96PR7	Gene names	H2AFB3, H2ABBD, H2AFB
Domain Architecture
Description	Histone H2A-Bbd (H2A Barr body-deficient) (H2A.Bbd).

H2AZ_HUMAN
NC score	0.338741 (rank : 30)	θ value	7.1131e-05 (rank : 67)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S5, P17317, Q6I9U0	Gene names	H2AFZ, H2AZ
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2AZ_MOUSE
NC score	0.338741 (rank : 31)	θ value	7.1131e-05 (rank : 68)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S6, P17317, Q3UA55, Q3UK43, Q68FD2	Gene names	H2afz, H2az
Domain Architecture	No domain graphic available
Description	Histone H2A.Z (H2A/z).

H2AV_HUMAN
NC score	0.338028 (rank : 32)	θ value	7.1131e-05 (rank : 65)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q71UI9, Q59GV8, Q6PK98	Gene names	H2AFV, H2AV
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2AV_MOUSE
NC score	0.338028 (rank : 33)	θ value	7.1131e-05 (rank : 66)
Query Neighborhood Hits	281	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	Q3THW5, Q5NC92, Q6ZWU0	Gene names	H2afv, H2av
Domain Architecture	No domain graphic available
Description	Histone H2AV (H2A.F/Z).

H2A1B_HUMAN
NC score	0.335483 (rank : 34)	θ value	6.43352e-06 (rank : 40)
Query Neighborhood Hits	281	Target Neighborhood Hits	39	Shared Neighborhood Hits	34
SwissProt Accessions	P04908	Gene names	HIST1H2AB, H2AFM
Domain Architecture
Description	Histone H2A type 1-B.

H2AX_MOUSE
NC score	0.334396 (rank : 35)	θ value	1.09739e-05 (rank : 46)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P27661	Gene names	H2afx, H2a.x, H2ax, Hist5-2ax
Domain Architecture
Description	Histone H2A.x (H2a/x).

H2AX_HUMAN
NC score	0.334220 (rank : 36)	θ value	1.09739e-05 (rank : 45)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P16104, Q4ZGJ7, Q6IAS5	Gene names	H2AFX, H2AX
Domain Architecture
Description	Histone H2A.x (H2a/x).

H2A2B_HUMAN
NC score	0.333664 (rank : 37)	θ value	1.09739e-05 (rank : 42)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IUE6	Gene names	HIST2H2AB
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B.

H2A3_HUMAN
NC score	0.332944 (rank : 38)	θ value	1.09739e-05 (rank : 43)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q7L7L0	Gene names	HIST3H2A
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2A3_MOUSE
NC score	0.332944 (rank : 39)	θ value	1.09739e-05 (rank : 44)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BFU2	Gene names	Hist3h2a
Domain Architecture	No domain graphic available
Description	Histone H2A type 3.

H2A1C_HUMAN
NC score	0.332941 (rank : 40)	θ value	1.09739e-05 (rank : 41)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q93077, O00775, O00776, O00777, O00778, Q540R1	Gene names	HIST1H2AC, H2AFL
Domain Architecture
Description	Histone H2A type 1-C.

H2A2C_HUMAN
NC score	0.332746 (rank : 41)	θ value	1.43324e-05 (rank : 61)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q16777, Q6DRA7, Q8IUE5	Gene names	HIST2H2AC, H2AFQ
Domain Architecture
Description	Histone H2A type 2-C (H2A-GL101) (H2A/r).

H2A2C_MOUSE
NC score	0.332746 (rank : 42)	θ value	1.43324e-05 (rank : 62)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64523, Q8CGP3	Gene names	Hist2h2ac, Hist2h2ab
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-C (H2a-613B).

H2A2B_MOUSE
NC score	0.332731 (rank : 43)	θ value	1.43324e-05 (rank : 60)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q64522	Gene names
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-B (H2a-613A).

H2A1J_HUMAN
NC score	0.332632 (rank : 44)	θ value	1.43324e-05 (rank : 54)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q99878, Q5JXQ5	Gene names	HIST1H2AJ, H2AFE
Domain Architecture
Description	Histone H2A type 1-J.

H2A1H_MOUSE
NC score	0.332531 (rank : 45)	θ value	1.43324e-05 (rank : 53)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP6	Gene names	Hist1h2ah
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1H_HUMAN
NC score	0.332518 (rank : 46)	θ value	1.43324e-05 (rank : 52)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96KK5	Gene names	HIST1H2AH, HIST1H2AI
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-H.

H2A1F_MOUSE
NC score	0.332361 (rank : 47)	θ value	1.43324e-05 (rank : 51)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP5	Gene names	Hist1h2af
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-F.

H2A1K_MOUSE
NC score	0.332316 (rank : 48)	θ value	1.43324e-05 (rank : 55)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGP7	Gene names	Hist1h2ak
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-K.

H2A1E_HUMAN
NC score	0.332211 (rank : 49)	θ value	1.43324e-05 (rank : 50)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P28001, Q76P63	Gene names	HIST1H2AE, H2AFA
Domain Architecture
Description	Histone H2A type 1-E (H2A.2) (H2A/m).

H2A1_MOUSE
NC score	0.332211 (rank : 50)	θ value	1.43324e-05 (rank : 57)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P22752, P10812, Q5SZZ2	Gene names	Hist1h2ab
Domain Architecture
Description	Histone H2A type 1.

H2A1D_HUMAN
NC score	0.332206 (rank : 51)	θ value	1.43324e-05 (rank : 49)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	34
SwissProt Accessions	P20671, P57754, Q6FGY6	Gene names	HIST1H2AD, H2AFG
Domain Architecture
Description	Histone H2A type 1-D (H2A.3).

H2A1_HUMAN
NC score	0.332200 (rank : 52)	θ value	1.43324e-05 (rank : 56)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	P0C0S8, P02261, Q2M1R2, Q76PA6	Gene names	HIST1H2AG, H2AFP
Domain Architecture	No domain graphic available
Description	Histone H2A type 1 (H2A.1).

H2A1A_HUMAN
NC score	0.332168 (rank : 53)	θ value	1.43324e-05 (rank : 48)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q96QV6	Gene names	HIST1H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 1-A.

H2A2A_HUMAN
NC score	0.332016 (rank : 54)	θ value	1.43324e-05 (rank : 58)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6FI13, P20670	Gene names	HIST2H2AA3, H2AFO, HIST2H2AA
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2).

H2A2A_MOUSE
NC score	0.332016 (rank : 55)	θ value	1.43324e-05 (rank : 59)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	34
SwissProt Accessions	Q6GSS7, P20670, Q811M3	Gene names	Hist2h2aa1
Domain Architecture	No domain graphic available
Description	Histone H2A type 2-A (H2A.2) (H2a-614) (H2a-615).

FGD4_HUMAN
NC score	0.308058 (rank : 56)	θ value	4.0297e-08 (rank : 32)
Query Neighborhood Hits	281	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.307938 (rank : 57)	θ value	1.38499e-08 (rank : 31)
Query Neighborhood Hits	281	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
NC score	0.307848 (rank : 58)	θ value	5.81887e-07 (rank : 35)
Query Neighborhood Hits	281	Target Neighborhood Hits	249	Shared Neighborhood Hits	40
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

H2AW_MOUSE
NC score	0.306834 (rank : 59)	θ value	0.00102713 (rank : 81)
Query Neighborhood Hits	281	Target Neighborhood Hits	57	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CCK0, Q3TNT4, Q925I6	Gene names	H2afy2, H2afy3
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

H2AW_HUMAN
NC score	0.306746 (rank : 60)	θ value	0.00102713 (rank : 80)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P0M6, Q5SQT2	Gene names	H2AFY2, MACROH2A2
Domain Architecture
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

FGD3_MOUSE
NC score	0.302821 (rank : 61)	θ value	1.43324e-05 (rank : 47)
Query Neighborhood Hits	281	Target Neighborhood Hits	257	Shared Neighborhood Hits	46
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ECT2_HUMAN
NC score	0.302150 (rank : 62)	θ value	6.43352e-06 (rank : 39)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG7_HUMAN
NC score	0.300922 (rank : 63)	θ value	2.13673e-09 (rank : 29)
Query Neighborhood Hits	281	Target Neighborhood Hits	347	Shared Neighborhood Hits	48
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

H2AY_MOUSE
NC score	0.297238 (rank : 64)	θ value	0.00175202 (rank : 84)
Query Neighborhood Hits	281	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZQ8, Q91VZ2, Q9QZQ7	Gene names	H2afy
Domain Architecture	No domain graphic available
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y).

H2AY_HUMAN
NC score	0.297093 (rank : 65)	θ value	0.00175202 (rank : 83)
Query Neighborhood Hits	281	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	O75367, O75377, Q503A8, Q7Z5E3, Q96D41, Q9H8P3, Q9UP96	Gene names	H2AFY, MACROH2A1
Domain Architecture
Description	Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) (Medulloblastoma antigen MU-MB-50.205).

ARHG7_MOUSE
NC score	0.295945 (rank : 66)	θ value	6.87365e-08 (rank : 33)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ECT2_MOUSE
NC score	0.294740 (rank : 67)	θ value	0.000121331 (rank : 69)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD2_HUMAN
NC score	0.283721 (rank : 68)	θ value	7.1131e-05 (rank : 64)
Query Neighborhood Hits	281	Target Neighborhood Hits	151	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD1_HUMAN
NC score	0.276676 (rank : 69)	θ value	0.00102713 (rank : 79)
Query Neighborhood Hits	281	Target Neighborhood Hits	367	Shared Neighborhood Hits	73
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.275089 (rank : 70)	θ value	0.00134147 (rank : 82)
Query Neighborhood Hits	281	Target Neighborhood Hits	387	Shared Neighborhood Hits	74
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG6_HUMAN
NC score	0.259905 (rank : 71)	θ value	3.19293e-05 (rank : 63)
Query Neighborhood Hits	281	Target Neighborhood Hits	376	Shared Neighborhood Hits	38
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

MCF2_HUMAN
NC score	0.252621 (rank : 72)	θ value	0.000461057 (rank : 75)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	44
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

VAV3_MOUSE
NC score	0.248205 (rank : 73)	θ value	6.21693e-09 (rank : 30)
Query Neighborhood Hits	281	Target Neighborhood Hits	404	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.247994 (rank : 74)	θ value	9.92553e-07 (rank : 37)
Query Neighborhood Hits	281	Target Neighborhood Hits	456	Shared Neighborhood Hits	48
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FGD2_MOUSE
NC score	0.244746 (rank : 75)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	281	Target Neighborhood Hits	163	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHG6_MOUSE
NC score	0.243439 (rank : 76)	θ value	0.00020696 (rank : 71)
Query Neighborhood Hits	281	Target Neighborhood Hits	394	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NGEF_HUMAN
NC score	0.240136 (rank : 77)	θ value	0.00228821 (rank : 86)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

VAV3_HUMAN
NC score	0.239188 (rank : 78)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	281	Target Neighborhood Hits	398	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV2_HUMAN
NC score	0.238348 (rank : 79)	θ value	0.000158464 (rank : 70)
Query Neighborhood Hits	281	Target Neighborhood Hits	453	Shared Neighborhood Hits	45
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FARP2_MOUSE
NC score	0.230223 (rank : 80)	θ value	3.77169e-06 (rank : 38)
Query Neighborhood Hits	281	Target Neighborhood Hits	209	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TIAM1_HUMAN
NC score	0.230192 (rank : 81)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	281	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.227009 (rank : 82)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	281	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FARP2_HUMAN
NC score	0.221992 (rank : 83)	θ value	9.92553e-07 (rank : 36)
Query Neighborhood Hits	281	Target Neighborhood Hits	240	Shared Neighborhood Hits	52
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

NGEF_MOUSE
NC score	0.220609 (rank : 84)	θ value	0.0330416 (rank : 97)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD6_MOUSE
NC score	0.202411 (rank : 85)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	281	Target Neighborhood Hits	282	Shared Neighborhood Hits	61
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ARHGA_MOUSE
NC score	0.201715 (rank : 86)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	281	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.197867 (rank : 87)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	281	Target Neighborhood Hits	187	Shared Neighborhood Hits	42
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2L_MOUSE
NC score	0.194264 (rank : 88)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	281	Target Neighborhood Hits	255	Shared Neighborhood Hits	48
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FGD6_HUMAN
NC score	0.191952 (rank : 89)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	281	Target Neighborhood Hits	237	Shared Neighborhood Hits	41
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHG3_HUMAN
NC score	0.186970 (rank : 90)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	281	Target Neighborhood Hits	82	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.186637 (rank : 91)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	33
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

VAV_HUMAN
NC score	0.185539 (rank : 92)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	281	Target Neighborhood Hits	452	Shared Neighborhood Hits	41
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.184590 (rank : 93)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	281	Target Neighborhood Hits	430	Shared Neighborhood Hits	40
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG5_HUMAN
NC score	0.183915 (rank : 94)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	281	Target Neighborhood Hits	172	Shared Neighborhood Hits	38
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

HAPIP_HUMAN
NC score	0.183839 (rank : 95)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	281	Target Neighborhood Hits	350	Shared Neighborhood Hits	46
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHGG_HUMAN
NC score	0.179851 (rank : 96)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	281	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.178965 (rank : 97)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	281	Target Neighborhood Hits	152	Shared Neighborhood Hits	39
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD5_MOUSE
NC score	0.172106 (rank : 98)	θ value	0.0431538 (rank : 99)
Query Neighborhood Hits	281	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
NC score	0.171729 (rank : 99)	θ value	0.0252991 (rank : 96)
Query Neighborhood Hits	281	Target Neighborhood Hits	235	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHG8_HUMAN
NC score	0.171295 (rank : 100)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	281	Target Neighborhood Hits	85	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

DNMBP_MOUSE
NC score	0.171045 (rank : 101)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	281	Target Neighborhood Hits	435	Shared Neighborhood Hits	55
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGF_HUMAN
NC score	0.170006 (rank : 102)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	281	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG8_MOUSE
NC score	0.168282 (rank : 103)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	281	Target Neighborhood Hits	79	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

PKHG4_HUMAN
NC score	0.167517 (rank : 104)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	281	Target Neighborhood Hits	200	Shared Neighborhood Hits	38
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FARP1_HUMAN
NC score	0.160748 (rank : 105)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	281	Target Neighborhood Hits	241	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHGB_HUMAN
NC score	0.157973 (rank : 106)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	281	Target Neighborhood Hits	375	Shared Neighborhood Hits	51
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ITSN1_MOUSE
NC score	0.157349 (rank : 107)	θ value	0.000270298 (rank : 74)
Query Neighborhood Hits	281	Target Neighborhood Hits	1669	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DNMBP_HUMAN
NC score	0.155399 (rank : 108)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	281	Target Neighborhood Hits	413	Shared Neighborhood Hits	48
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN1_HUMAN
NC score	0.155240 (rank : 109)	θ value	0.000270298 (rank : 73)
Query Neighborhood Hits	281	Target Neighborhood Hits	1757	Shared Neighborhood Hits	102
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
NC score	0.142238 (rank : 110)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	281	Target Neighborhood Hits	1173	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

BCR_HUMAN
NC score	0.141167 (rank : 111)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	43
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.140463 (rank : 112)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	281	Target Neighborhood Hits	166	Shared Neighborhood Hits	38
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHGC_HUMAN
NC score	0.136235 (rank : 113)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	281	Target Neighborhood Hits	351	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITSN2_MOUSE
NC score	0.134493 (rank : 114)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	281	Target Neighborhood Hits	1371	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHGC_MOUSE
NC score	0.131502 (rank : 115)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	281	Target Neighborhood Hits	344	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
NC score	0.123681 (rank : 116)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	281	Target Neighborhood Hits	176	Shared Neighborhood Hits	30
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

RGNEF_MOUSE
NC score	0.121584 (rank : 117)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	55
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG2_MOUSE
NC score	0.121517 (rank : 118)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	35
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
NC score	0.108482 (rank : 119)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	281	Target Neighborhood Hits	142	Shared Neighborhood Hits	35
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

LBC_HUMAN
NC score	0.104018 (rank : 120)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	281	Target Neighborhood Hits	90	Shared Neighborhood Hits	26
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG1_MOUSE
NC score	0.099802 (rank : 121)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	281	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

NCOA6_HUMAN
NC score	0.088225 (rank : 122)	θ value	0.000461057 (rank : 76)
Query Neighborhood Hits	281	Target Neighborhood Hits	1202	Shared Neighborhood Hits	101
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NACAM_MOUSE
NC score	0.087363 (rank : 123)	θ value	0.000602161 (rank : 77)
Query Neighborhood Hits	281	Target Neighborhood Hits	1866	Shared Neighborhood Hits	134
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MLL3_MOUSE
NC score	0.085798 (rank : 124)	θ value	0.00228821 (rank : 85)
Query Neighborhood Hits	281	Target Neighborhood Hits	1399	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

TRIO_HUMAN
NC score	0.085294 (rank : 125)	θ value	0.00509761 (rank : 90)
Query Neighborhood Hits	281	Target Neighborhood Hits	1580	Shared Neighborhood Hits	87
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MLL3_HUMAN
NC score	0.083983 (rank : 126)	θ value	0.00298849 (rank : 88)
Query Neighborhood Hits	281	Target Neighborhood Hits	1644	Shared Neighborhood Hits	108
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

SRRM1_HUMAN
NC score	0.083830 (rank : 127)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	281	Target Neighborhood Hits	690	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

BCL9_HUMAN
NC score	0.081563 (rank : 128)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	281	Target Neighborhood Hits	1008	Shared Neighborhood Hits	85
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

MUC7_HUMAN
NC score	0.077399 (rank : 129)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	281	Target Neighborhood Hits	538	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCOA6_MOUSE
NC score	0.075043 (rank : 130)	θ value	2.36792 (rank : 177)
Query Neighborhood Hits	281	Target Neighborhood Hits	1076	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

WASIP_HUMAN
NC score	0.071544 (rank : 131)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	281	Target Neighborhood Hits	458	Shared Neighborhood Hits	73
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

BLNK_MOUSE
NC score	0.071474 (rank : 132)	θ value	0.125558 (rank : 104)
Query Neighborhood Hits	281	Target Neighborhood Hits	296	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

MDC1_HUMAN
NC score	0.070783 (rank : 133)	θ value	0.0431538 (rank : 100)
Query Neighborhood Hits	281	Target Neighborhood Hits	1446	Shared Neighborhood Hits	99
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PKHF2_HUMAN
NC score	0.069800 (rank : 134)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	281	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.069791 (rank : 135)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	281	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PER3_HUMAN
NC score	0.069449 (rank : 136)	θ value	0.000786445 (rank : 78)
Query Neighborhood Hits	281	Target Neighborhood Hits	479	Shared Neighborhood Hits	51
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

DUET_HUMAN
NC score	0.069201 (rank : 137)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	281	Target Neighborhood Hits	1220	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

GSCR1_HUMAN
NC score	0.069157 (rank : 138)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	281	Target Neighborhood Hits	674	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

SH3K1_HUMAN
NC score	0.068215 (rank : 139)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	281	Target Neighborhood Hits	341	Shared Neighborhood Hits	33
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PRG4_HUMAN
NC score	0.068176 (rank : 140)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	281	Target Neighborhood Hits	764	Shared Neighborhood Hits	92
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CT152_HUMAN
NC score	0.067736 (rank : 141)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	281	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

NCF1_HUMAN
NC score	0.067033 (rank : 142)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

BCL9_MOUSE
NC score	0.066803 (rank : 143)	θ value	2.36792 (rank : 168)
Query Neighborhood Hits	281	Target Neighborhood Hits	770	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

PRP1_HUMAN
NC score	0.066545 (rank : 144)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	281	Target Neighborhood Hits	385	Shared Neighborhood Hits	58
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PKHF1_HUMAN
NC score	0.065969 (rank : 145)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	281	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

SON_HUMAN
NC score	0.065946 (rank : 146)	θ value	0.0113563 (rank : 93)
Query Neighborhood Hits	281	Target Neighborhood Hits	1568	Shared Neighborhood Hits	91
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SRRM1_MOUSE
NC score	0.065842 (rank : 147)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	281	Target Neighborhood Hits	966	Shared Neighborhood Hits	92
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

RAPH1_HUMAN
NC score	0.065745 (rank : 148)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	281	Target Neighborhood Hits	593	Shared Neighborhood Hits	94
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

MLL2_HUMAN
NC score	0.065228 (rank : 149)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	281	Target Neighborhood Hits	1788	Shared Neighborhood Hits	132
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RGS3_MOUSE
NC score	0.065037 (rank : 150)	θ value	0.0193708 (rank : 95)
Query Neighborhood Hits	281	Target Neighborhood Hits	1621	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TCGAP_HUMAN
NC score	0.064804 (rank : 151)	θ value	0.125558 (rank : 107)
Query Neighborhood Hits	281	Target Neighborhood Hits	872	Shared Neighborhood Hits	75
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

HCLS1_HUMAN
NC score	0.064508 (rank : 152)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	281	Target Neighborhood Hits	358	Shared Neighborhood Hits	36
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PKHF1_MOUSE
NC score	0.064195 (rank : 153)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	281	Target Neighborhood Hits	80	Shared Neighborhood Hits	15
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SH3K1_MOUSE
NC score	0.063698 (rank : 154)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	281	Target Neighborhood Hits	332	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
NC score	0.063347 (rank : 155)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	281	Target Neighborhood Hits	315	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

HCLS1_MOUSE
NC score	0.063012 (rank : 156)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	281	Target Neighborhood Hits	329	Shared Neighborhood Hits	48
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CD2AP_MOUSE
NC score	0.062750 (rank : 157)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	281	Target Neighborhood Hits	336	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

STAC_HUMAN
NC score	0.062720 (rank : 158)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	281	Target Neighborhood Hits	276	Shared Neighborhood Hits	20
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PRP2_MOUSE
NC score	0.062175 (rank : 159)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	281	Target Neighborhood Hits	347	Shared Neighborhood Hits	55
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

WASIP_MOUSE
NC score	0.061538 (rank : 160)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	281	Target Neighborhood Hits	392	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

PRG4_MOUSE
NC score	0.060484 (rank : 161)	θ value	5.27518 (rank : 219)
Query Neighborhood Hits	281	Target Neighborhood Hits	624	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

STAC_MOUSE
NC score	0.060338 (rank : 162)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	281	Target Neighborhood Hits	268	Shared Neighborhood Hits	20
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PRR12_HUMAN
NC score	0.059966 (rank : 163)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	281	Target Neighborhood Hits	460	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

NCF1_MOUSE
NC score	0.059705 (rank : 164)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	281	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

MDC1_MOUSE
NC score	0.059038 (rank : 165)	θ value	8.99809 (rank : 265)
Query Neighborhood Hits	281	Target Neighborhood Hits	998	Shared Neighborhood Hits	90
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

SRRM2_HUMAN
NC score	0.058493 (rank : 166)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	281	Target Neighborhood Hits	1296	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ABI2_HUMAN
NC score	0.058450 (rank : 167)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	281	Target Neighborhood Hits	350	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SRRM2_MOUSE
NC score	0.058378 (rank : 168)	θ value	4.03905 (rank : 201)
Query Neighborhood Hits	281	Target Neighborhood Hits	1470	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

WBP11_HUMAN
NC score	0.058319 (rank : 169)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	281	Target Neighborhood Hits	354	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

MBD6_HUMAN
NC score	0.058174 (rank : 170)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	281	Target Neighborhood Hits	349	Shared Neighborhood Hits	57
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

SRBS1_HUMAN
NC score	0.057845 (rank : 171)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	281	Target Neighborhood Hits	396	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DRAP1_HUMAN
NC score	0.057586 (rank : 172)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	281	Target Neighborhood Hits	51	Shared Neighborhood Hits	26
SwissProt Accessions	Q14919, Q13448	Gene names	DRAP1
Domain Architecture	No domain graphic available
Description	Dr1-associated corepressor (Dr1-associated protein 1) (Negative co- factor 2 alpha) (NC2 alpha).

NCF4_MOUSE
NC score	0.056964 (rank : 173)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	281	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

TARA_MOUSE
NC score	0.056814 (rank : 174)	θ value	0.279714 (rank : 119)
Query Neighborhood Hits	281	Target Neighborhood Hits	1133	Shared Neighborhood Hits	79
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MUC1_HUMAN
NC score	0.056780 (rank : 175)	θ value	0.00020696 (rank : 72)
Query Neighborhood Hits	281	Target Neighborhood Hits	975	Shared Neighborhood Hits	66
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NCF4_HUMAN
NC score	0.056716 (rank : 176)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CS016_HUMAN
NC score	0.056630 (rank : 177)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	49
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

WBP11_MOUSE
NC score	0.056441 (rank : 178)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	281	Target Neighborhood Hits	362	Shared Neighborhood Hits	55
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

SYNJ1_MOUSE
NC score	0.056077 (rank : 179)	θ value	0.125558 (rank : 106)
Query Neighborhood Hits	281	Target Neighborhood Hits	516	Shared Neighborhood Hits	73
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

WIRE_HUMAN
NC score	0.055941 (rank : 180)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	281	Target Neighborhood Hits	329	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ZN645_HUMAN
NC score	0.055683 (rank : 181)	θ value	1.06291 (rank : 148)
Query Neighborhood Hits	281	Target Neighborhood Hits	265	Shared Neighborhood Hits	21
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

GRAP_HUMAN
NC score	0.055535 (rank : 182)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	281	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PCLO_HUMAN
NC score	0.055257 (rank : 183)	θ value	0.365318 (rank : 124)
Query Neighborhood Hits	281	Target Neighborhood Hits	2046	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

DAB2_MOUSE
NC score	0.055218 (rank : 184)	θ value	0.47712 (rank : 125)
Query Neighborhood Hits	281	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

GRAP_MOUSE
NC score	0.054971 (rank : 185)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	281	Target Neighborhood Hits	309	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

DRAP1_MOUSE
NC score	0.054859 (rank : 186)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	281	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D6N5	Gene names	Drap1
Domain Architecture	No domain graphic available
Description	Dr1-associated corepressor (Dr1-associated protein 1) (Negative co- factor 2 alpha) (NC2 alpha).

SYNPO_HUMAN
NC score	0.054715 (rank : 187)	θ value	0.47712 (rank : 127)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

CJ012_HUMAN
NC score	0.054317 (rank : 188)	θ value	1.38821 (rank : 150)
Query Neighborhood Hits	281	Target Neighborhood Hits	467	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

YLPM1_MOUSE
NC score	0.054074 (rank : 189)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	281	Target Neighborhood Hits	505	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

GP155_HUMAN
NC score	0.054047 (rank : 190)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	281	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

SRBS1_MOUSE
NC score	0.053860 (rank : 191)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	281	Target Neighborhood Hits	409	Shared Neighborhood Hits	36
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CT152_MOUSE
NC score	0.053633 (rank : 192)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	281	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

RERE_MOUSE
NC score	0.053050 (rank : 193)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	281	Target Neighborhood Hits	785	Shared Neighborhood Hits	88
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SHAN1_HUMAN
NC score	0.052847 (rank : 194)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	281	Target Neighborhood Hits	1041	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PRB3_HUMAN
NC score	0.052660 (rank : 195)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	281	Target Neighborhood Hits	318	Shared Neighborhood Hits	50
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

MILK1_MOUSE
NC score	0.052532 (rank : 196)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	281	Target Neighborhood Hits	788	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

GRAP2_HUMAN
NC score	0.052354 (rank : 197)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	281	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

WIRE_MOUSE
NC score	0.052343 (rank : 198)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	281	Target Neighborhood Hits	310	Shared Neighborhood Hits	52
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

BRD4_MOUSE
NC score	0.052161 (rank : 199)	θ value	2.36792 (rank : 169)
Query Neighborhood Hits	281	Target Neighborhood Hits	845	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

GRAP2_MOUSE
NC score	0.051906 (rank : 200)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	281	Target Neighborhood Hits	297	Shared Neighborhood Hits	17
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ATX2_MOUSE
NC score	0.051791 (rank : 201)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	281	Target Neighborhood Hits	445	Shared Neighborhood Hits	64
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

STAC3_MOUSE
NC score	0.051546 (rank : 202)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	281	Target Neighborhood Hits	232	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ENAH_MOUSE
NC score	0.051210 (rank : 203)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	281	Target Neighborhood Hits	919	Shared Neighborhood Hits	87
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

PKHA6_MOUSE
NC score	0.051059 (rank : 204)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	281	Target Neighborhood Hits	591	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

MUC1_MOUSE
NC score	0.050892 (rank : 205)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	281	Target Neighborhood Hits	388	Shared Neighborhood Hits	41
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

PRB4S_HUMAN
NC score	0.050791 (rank : 206)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	281	Target Neighborhood Hits	330	Shared Neighborhood Hits	51
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

TARSH_HUMAN
NC score	0.050716 (rank : 207)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	281	Target Neighborhood Hits	768	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

STAC3_HUMAN
NC score	0.050664 (rank : 208)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCK1_HUMAN
NC score	0.050500 (rank : 209)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ZN207_HUMAN
NC score	0.050170 (rank : 210)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	281	Target Neighborhood Hits	326	Shared Neighborhood Hits	35
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

ATN1_HUMAN
NC score	0.050159 (rank : 211)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	281	Target Neighborhood Hits	676	Shared Neighborhood Hits	80
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BAZ2A_HUMAN
NC score	0.049657 (rank : 212)	θ value	0.0961366 (rank : 102)
Query Neighborhood Hits	281	Target Neighborhood Hits	780	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

REPS1_MOUSE
NC score	0.049005 (rank : 213)	θ value	2.36792 (rank : 179)
Query Neighborhood Hits	281	Target Neighborhood Hits	204	Shared Neighborhood Hits	28
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

TAB3_MOUSE
NC score	0.048927 (rank : 214)	θ value	0.813845 (rank : 143)
Query Neighborhood Hits	281	Target Neighborhood Hits	273	Shared Neighborhood Hits	44
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

SPTB2_HUMAN
NC score	0.048052 (rank : 215)	θ value	0.00665767 (rank : 91)
Query Neighborhood Hits	281	Target Neighborhood Hits	748	Shared Neighborhood Hits	38
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TARA_HUMAN
NC score	0.047743 (rank : 216)	θ value	0.21417 (rank : 115)
Query Neighborhood Hits	281	Target Neighborhood Hits	1626	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CNOT4_MOUSE
NC score	0.047229 (rank : 217)	θ value	0.21417 (rank : 111)
Query Neighborhood Hits	281	Target Neighborhood Hits	277	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CD008_HUMAN
NC score	0.047175 (rank : 218)	θ value	1.06291 (rank : 145)
Query Neighborhood Hits	281	Target Neighborhood Hits	330	Shared Neighborhood Hits	28
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

OBSCN_HUMAN
NC score	0.046390 (rank : 219)	θ value	0.0330416 (rank : 98)
Query Neighborhood Hits	281	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ATX2_HUMAN
NC score	0.045944 (rank : 220)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	281	Target Neighborhood Hits	375	Shared Neighborhood Hits	55
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

SPTB2_MOUSE
NC score	0.045417 (rank : 221)	θ value	0.00665767 (rank : 92)
Query Neighborhood Hits	281	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

HRX_HUMAN
NC score	0.045291 (rank : 222)	θ value	1.81305 (rank : 162)
Query Neighborhood Hits	281	Target Neighborhood Hits	825	Shared Neighborhood Hits	65
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

FEZ1_HUMAN
NC score	0.045289 (rank : 223)	θ value	0.21417 (rank : 112)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	7
SwissProt Accessions	Q99689, O00679, O00728, Q6IBI7	Gene names	FEZ1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

MINT_HUMAN
NC score	0.044886 (rank : 224)	θ value	1.81305 (rank : 164)
Query Neighborhood Hits	281	Target Neighborhood Hits	1291	Shared Neighborhood Hits	89
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SOX30_MOUSE
NC score	0.044865 (rank : 225)	θ value	0.279714 (rank : 118)
Query Neighborhood Hits	281	Target Neighborhood Hits	374	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

CNOT4_HUMAN
NC score	0.043553 (rank : 226)	θ value	0.365318 (rank : 122)
Query Neighborhood Hits	281	Target Neighborhood Hits	207	Shared Neighborhood Hits	12
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

SPTN4_HUMAN
NC score	0.043112 (rank : 227)	θ value	0.21417 (rank : 114)
Query Neighborhood Hits	281	Target Neighborhood Hits	570	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

DACT1_HUMAN
NC score	0.042662 (rank : 228)	θ value	0.163984 (rank : 108)
Query Neighborhood Hits	281	Target Neighborhood Hits	228	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

REPS1_HUMAN
NC score	0.042452 (rank : 229)	θ value	0.813845 (rank : 142)
Query Neighborhood Hits	281	Target Neighborhood Hits	205	Shared Neighborhood Hits	26
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

SFPQ_MOUSE
NC score	0.042383 (rank : 230)	θ value	6.88961 (rank : 246)
Query Neighborhood Hits	281	Target Neighborhood Hits	958	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

4ET_HUMAN
NC score	0.042230 (rank : 231)	θ value	1.06291 (rank : 144)
Query Neighborhood Hits	281	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NRA8, Q8NCF2, Q9H708	Gene names	EIF4ENIF1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

SOX13_HUMAN
NC score	0.042017 (rank : 232)	θ value	0.163984 (rank : 110)
Query Neighborhood Hits	281	Target Neighborhood Hits	464	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

BIM_MOUSE
NC score	0.041580 (rank : 233)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	281	Target Neighborhood Hits	124	Shared Neighborhood Hits	12
SwissProt Accessions	O54918, O54919, O54920	Gene names	Bcl2l11, Bim
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

ZIMP7_MOUSE
NC score	0.040917 (rank : 234)	θ value	2.36792 (rank : 181)
Query Neighborhood Hits	281	Target Neighborhood Hits	566	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

S23IP_MOUSE
NC score	0.040894 (rank : 235)	θ value	1.06291 (rank : 147)
Query Neighborhood Hits	281	Target Neighborhood Hits	363	Shared Neighborhood Hits	42
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

TNR8_MOUSE
NC score	0.040474 (rank : 236)	θ value	0.62314 (rank : 134)
Query Neighborhood Hits	281	Target Neighborhood Hits	208	Shared Neighborhood Hits	10
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

NCOR2_HUMAN
NC score	0.040386 (rank : 237)	θ value	0.813845 (rank : 138)
Query Neighborhood Hits	281	Target Neighborhood Hits	870	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

MINT_MOUSE
NC score	0.039556 (rank : 238)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	281	Target Neighborhood Hits	1514	Shared Neighborhood Hits	81
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

FYB_MOUSE
NC score	0.039198 (rank : 239)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	281	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

FA47A_HUMAN
NC score	0.038740 (rank : 240)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	281	Target Neighborhood Hits	451	Shared Neighborhood Hits	42
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

RUNX2_MOUSE
NC score	0.038640 (rank : 241)	θ value	0.62314 (rank : 131)
Query Neighborhood Hits	281	Target Neighborhood Hits	119	Shared Neighborhood Hits	21
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

TACC2_MOUSE
NC score	0.038151 (rank : 242)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	281	Target Neighborhood Hits	774	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

ANK2_HUMAN
NC score	0.037391 (rank : 243)	θ value	0.00509761 (rank : 89)
Query Neighborhood Hits	281	Target Neighborhood Hits	1615	Shared Neighborhood Hits	99
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

RUNX2_HUMAN
NC score	0.036633 (rank : 244)	θ value	1.38821 (rank : 156)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	22
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

BIM_HUMAN
NC score	0.035045 (rank : 245)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	281	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	O43521, O43522	Gene names	BCL2L11, BIM
Domain Architecture
Description	Bcl-2-like protein 11 (Bcl2-interacting mediator of cell death).

CEP68_HUMAN
NC score	0.034213 (rank : 246)	θ value	1.81305 (rank : 159)
Query Neighborhood Hits	281	Target Neighborhood Hits	128	Shared Neighborhood Hits	17
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

SOX30_HUMAN
NC score	0.033961 (rank : 247)	θ value	0.279714 (rank : 117)
Query Neighborhood Hits	281	Target Neighborhood Hits	305	Shared Neighborhood Hits	30
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

TAU_HUMAN
NC score	0.033438 (rank : 248)	θ value	6.88961 (rank : 249)
Query Neighborhood Hits	281	Target Neighborhood Hits	448	Shared Neighborhood Hits	49
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

NUP53_HUMAN
NC score	0.033252 (rank : 249)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	281	Target Neighborhood Hits	156	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

EPN3_HUMAN
NC score	0.032827 (rank : 250)	θ value	0.813845 (rank : 137)
Query Neighborhood Hits	281	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

TACC2_HUMAN
NC score	0.032688 (rank : 251)	θ value	6.88961 (rank : 248)
Query Neighborhood Hits	281	Target Neighborhood Hits	856	Shared Neighborhood Hits	63
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

SPTN2_HUMAN
NC score	0.032533 (rank : 252)	θ value	2.36792 (rank : 180)
Query Neighborhood Hits	281	Target Neighborhood Hits	535	Shared Neighborhood Hits	30
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

OSBL9_HUMAN
NC score	0.032128 (rank : 253)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	281	Target Neighborhood Hits	138	Shared Neighborhood Hits	19
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

NFH_MOUSE
NC score	0.032063 (rank : 254)	θ value	0.279714 (rank : 116)
Query Neighborhood Hits	281	Target Neighborhood Hits	2247	Shared Neighborhood Hits	116
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SPT5H_MOUSE
NC score	0.031681 (rank : 255)	θ value	5.27518 (rank : 227)
Query Neighborhood Hits	281	Target Neighborhood Hits	437	Shared Neighborhood Hits	44
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

JPH2_HUMAN
NC score	0.031525 (rank : 256)	θ value	0.365318 (rank : 123)
Query Neighborhood Hits	281	Target Neighborhood Hits	639	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

SPT5H_HUMAN
NC score	0.031513 (rank : 257)	θ value	5.27518 (rank : 226)
Query Neighborhood Hits	281	Target Neighborhood Hits	436	Shared Neighborhood Hits	43
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

ZIM10_HUMAN
NC score	0.031395 (rank : 258)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	281	Target Neighborhood Hits	577	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

EP15_HUMAN
NC score	0.031366 (rank : 259)	θ value	2.36792 (rank : 174)
Query Neighborhood Hits	281	Target Neighborhood Hits	1021	Shared Neighborhood Hits	50
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

LR37A_HUMAN
NC score	0.031295 (rank : 260)	θ value	1.38821 (rank : 151)
Query Neighborhood Hits	281	Target Neighborhood Hits	720	Shared Neighborhood Hits	49
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

4ET_MOUSE
NC score	0.031134 (rank : 261)	θ value	1.81305 (rank : 158)
Query Neighborhood Hits	281	Target Neighborhood Hits	103	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EST3, Q9CSS3	Gene names	Eif4enif1, Clast4
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

K1802_MOUSE
NC score	0.031116 (rank : 262)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	281	Target Neighborhood Hits	1596	Shared Neighborhood Hits	92
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LARP4_MOUSE
NC score	0.030967 (rank : 263)	θ value	2.36792 (rank : 176)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

MAGE1_HUMAN
NC score	0.030848 (rank : 264)	θ value	6.88961 (rank : 240)
Query Neighborhood Hits	281	Target Neighborhood Hits	1389	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

TACC1_MOUSE
NC score	0.029584 (rank : 265)	θ value	0.62314 (rank : 133)
Query Neighborhood Hits	281	Target Neighborhood Hits	667	Shared Neighborhood Hits	43
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

K1683_HUMAN
NC score	0.029511 (rank : 266)	θ value	6.88961 (rank : 234)
Query Neighborhood Hits	281	Target Neighborhood Hits	240	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

RUNX1_HUMAN
NC score	0.029204 (rank : 267)	θ value	1.38821 (rank : 155)
Query Neighborhood Hits	281	Target Neighborhood Hits	94	Shared Neighborhood Hits	10
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

JADE2_MOUSE
NC score	0.028995 (rank : 268)	θ value	0.62314 (rank : 129)
Query Neighborhood Hits	281	Target Neighborhood Hits	560	Shared Neighborhood Hits	43
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

TPM1_HUMAN
NC score	0.028808 (rank : 269)	θ value	0.62314 (rank : 135)
Query Neighborhood Hits	281	Target Neighborhood Hits	716	Shared Neighborhood Hits	31
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

SPTN5_HUMAN
NC score	0.028599 (rank : 270)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	281	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

CD248_HUMAN
NC score	0.028514 (rank : 271)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	281	Target Neighborhood Hits	679	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

TPM1_MOUSE
NC score	0.028492 (rank : 272)	θ value	0.62314 (rank : 136)
Query Neighborhood Hits	281	Target Neighborhood Hits	729	Shared Neighborhood Hits	33
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

MYST3_HUMAN
NC score	0.027617 (rank : 273)	θ value	4.03905 (rank : 195)
Query Neighborhood Hits	281	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

SETBP_HUMAN
NC score	0.027610 (rank : 274)	θ value	6.88961 (rank : 245)
Query Neighborhood Hits	281	Target Neighborhood Hits	305	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

RUNX1_MOUSE
NC score	0.026653 (rank : 275)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	281	Target Neighborhood Hits	93	Shared Neighborhood Hits	13
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

ETV3_HUMAN
NC score	0.026624 (rank : 276)	θ value	0.47712 (rank : 126)
Query Neighborhood Hits	281	Target Neighborhood Hits	312	Shared Neighborhood Hits	31
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

MAP1B_HUMAN
NC score	0.026577 (rank : 277)	θ value	6.88961 (rank : 241)
Query Neighborhood Hits	281	Target Neighborhood Hits	903	Shared Neighborhood Hits	62
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

RC3H1_HUMAN
NC score	0.026488 (rank : 278)	θ value	0.813845 (rank : 141)
Query Neighborhood Hits	281	Target Neighborhood Hits	433	Shared Neighborhood Hits	26
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

C2TA_HUMAN
NC score	0.026382 (rank : 279)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	281	Target Neighborhood Hits	190	Shared Neighborhood Hits	22
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

CECR2_HUMAN
NC score	0.026314 (rank : 280)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	281	Target Neighborhood Hits	543	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

NDUB7_MOUSE
NC score	0.025436 (rank : 281)	θ value	2.36792 (rank : 178)
Query Neighborhood Hits	281	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CR61	Gene names	Ndufb7
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase B18 subunit) (Complex I-B18) (CI-B18).

GNAS1_MOUSE
NC score	0.025416 (rank : 282)	θ value	0.0961366 (rank : 103)
Query Neighborhood Hits	281	Target Neighborhood Hits	651	Shared Neighborhood Hits	49
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

FYCO1_MOUSE
NC score	0.025310 (rank : 283)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	281	Target Neighborhood Hits	1059	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

RRBP1_MOUSE
NC score	0.024862 (rank : 284)	θ value	0.0431538 (rank : 101)
Query Neighborhood Hits	281	Target Neighborhood Hits	1650	Shared Neighborhood Hits	59
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CD248_MOUSE
NC score	0.024498 (rank : 285)	θ value	2.36792 (rank : 170)
Query Neighborhood Hits	281	Target Neighborhood Hits	578	Shared Neighborhood Hits	45
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

TPM3_HUMAN
NC score	0.024324 (rank : 286)	θ value	6.88961 (rank : 250)
Query Neighborhood Hits	281	Target Neighborhood Hits	689	Shared Neighborhood Hits	32
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

SPR1B_MOUSE
NC score	0.024295 (rank : 287)	θ value	5.27518 (rank : 225)
Query Neighborhood Hits	281	Target Neighborhood Hits	395	Shared Neighborhood Hits	36
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

TPM3_MOUSE
NC score	0.023680 (rank : 288)	θ value	6.88961 (rank : 251)
Query Neighborhood Hits	281	Target Neighborhood Hits	676	Shared Neighborhood Hits	31
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

TRI66_HUMAN
NC score	0.023471 (rank : 289)	θ value	6.88961 (rank : 252)
Query Neighborhood Hits	281	Target Neighborhood Hits	479	Shared Neighborhood Hits	38
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

MACF4_HUMAN
NC score	0.023108 (rank : 290)	θ value	6.88961 (rank : 239)
Query Neighborhood Hits	281	Target Neighborhood Hits	1321	Shared Neighborhood Hits	57
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

SETX_HUMAN
NC score	0.022892 (rank : 291)	θ value	5.27518 (rank : 224)
Query Neighborhood Hits	281	Target Neighborhood Hits	368	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

NUP53_MOUSE
NC score	0.022513 (rank : 292)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	281	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

MACF1_HUMAN
NC score	0.021866 (rank : 293)	θ value	6.88961 (rank : 238)
Query Neighborhood Hits	281	Target Neighborhood Hits	1341	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

LRCH1_MOUSE
NC score	0.021847 (rank : 294)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	281	Target Neighborhood Hits	264	Shared Neighborhood Hits	15
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

CSKI2_MOUSE
NC score	0.021679 (rank : 295)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	281	Target Neighborhood Hits	812	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

TIF1G_MOUSE
NC score	0.021606 (rank : 296)	θ value	4.03905 (rank : 202)
Query Neighborhood Hits	281	Target Neighborhood Hits	498	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

CRIS2_MOUSE
NC score	0.021438 (rank : 297)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	281	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	P16563	Gene names	Crisp2, Tpx-1, Tpx1
Domain Architecture
Description	Cysteine-rich secretory protein 2 precursor (CRISP-2) (Testis-specific protein TPX-1).

CI061_HUMAN
NC score	0.021072 (rank : 298)	θ value	2.36792 (rank : 172)
Query Neighborhood Hits	281	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q15884, Q5T6C8, Q5T6C9, Q96N10	Gene names	C9orf61, X123
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf61 (Protein X123).

JPH1_MOUSE
NC score	0.020864 (rank : 299)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	281	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

CENPF_HUMAN
NC score	0.019884 (rank : 300)	θ value	1.38821 (rank : 149)
Query Neighborhood Hits	281	Target Neighborhood Hits	1932	Shared Neighborhood Hits	62
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

LPP_HUMAN
NC score	0.019418 (rank : 301)	θ value	6.88961 (rank : 237)
Query Neighborhood Hits	281	Target Neighborhood Hits	775	Shared Neighborhood Hits	55
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

PHF12_MOUSE
NC score	0.019330 (rank : 302)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	281	Target Neighborhood Hits	172	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

SCMH1_MOUSE
NC score	0.019227 (rank : 303)	θ value	5.27518 (rank : 222)
Query Neighborhood Hits	281	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K214, Q9JME0	Gene names	Scmh1
Domain Architecture	No domain graphic available
Description	Polycomb protein SCMH1 (Sex comb on midleg homolog 1).

GOGB1_HUMAN
NC score	0.019068 (rank : 304)	θ value	1.81305 (rank : 161)
Query Neighborhood Hits	281	Target Neighborhood Hits	2297	Shared Neighborhood Hits	71
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

PO6F2_MOUSE
NC score	0.019060 (rank : 305)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	281	Target Neighborhood Hits	639	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

C2TA_MOUSE
NC score	0.018741 (rank : 306)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	281	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CEND1_MOUSE
NC score	0.018460 (rank : 307)	θ value	2.36792 (rank : 171)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

MYO15_HUMAN
NC score	0.018395 (rank : 308)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	281	Target Neighborhood Hits	671	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

SCMH1_HUMAN
NC score	0.017575 (rank : 309)	θ value	5.27518 (rank : 221)
Query Neighborhood Hits	281	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	Q96GD3, Q5VT76, Q6IAJ4, Q8WU48, Q9UKM5, Q9UKM6	Gene names	SCMH1
Domain Architecture	No domain graphic available
Description	Polycomb protein SCMH1 (Sex comb on midleg homolog 1).

ERRFI_MOUSE
NC score	0.017413 (rank : 310)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	281	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

UBP53_MOUSE
NC score	0.017344 (rank : 311)	θ value	4.03905 (rank : 204)
Query Neighborhood Hits	281	Target Neighborhood Hits	188	Shared Neighborhood Hits	13
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

SIG10_HUMAN
NC score	0.017234 (rank : 312)	θ value	0.125558 (rank : 105)
Query Neighborhood Hits	281	Target Neighborhood Hits	363	Shared Neighborhood Hits	15
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

CCD39_HUMAN
NC score	0.017176 (rank : 313)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	281	Target Neighborhood Hits	868	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

GP152_MOUSE
NC score	0.016802 (rank : 314)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	281	Target Neighborhood Hits	607	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

SEM6D_HUMAN
NC score	0.016541 (rank : 315)	θ value	0.62314 (rank : 132)
Query Neighborhood Hits	281	Target Neighborhood Hits	169	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

PTN4_HUMAN
NC score	0.016421 (rank : 316)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	281	Target Neighborhood Hits	303	Shared Neighborhood Hits	13
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

NOP14_HUMAN
NC score	0.016338 (rank : 317)	θ value	5.27518 (rank : 217)
Query Neighborhood Hits	281	Target Neighborhood Hits	573	Shared Neighborhood Hits	30
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

UBP42_HUMAN
NC score	0.016279 (rank : 318)	θ value	4.03905 (rank : 203)
Query Neighborhood Hits	281	Target Neighborhood Hits	445	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

CAC1G_HUMAN
NC score	0.016186 (rank : 319)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	281	Target Neighborhood Hits	587	Shared Neighborhood Hits	43
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

EXOC6_MOUSE
NC score	0.014283 (rank : 320)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	281	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R313	Gene names	Exoc6, Sec15a, Sec15l1
Domain Architecture
Description	Exocyst complex component 6 (Exocyst complex component Sec15A) (Sec15- like 1).

PHF3_HUMAN
NC score	0.014255 (rank : 321)	θ value	5.27518 (rank : 218)
Query Neighborhood Hits	281	Target Neighborhood Hits	419	Shared Neighborhood Hits	21
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

APLP1_MOUSE
NC score	0.014220 (rank : 322)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	281	Target Neighborhood Hits	130	Shared Neighborhood Hits	12
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

EHMT2_MOUSE
NC score	0.014132 (rank : 323)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	281	Target Neighborhood Hits	750	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

RAI14_HUMAN
NC score	0.014119 (rank : 324)	θ value	1.38821 (rank : 153)
Query Neighborhood Hits	281	Target Neighborhood Hits	1367	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

NCOA2_MOUSE
NC score	0.013892 (rank : 325)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	281	Target Neighborhood Hits	281	Shared Neighborhood Hits	26
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

CAC1H_MOUSE
NC score	0.013806 (rank : 326)	θ value	0.365318 (rank : 121)
Query Neighborhood Hits	281	Target Neighborhood Hits	230	Shared Neighborhood Hits	14
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

NAF1_HUMAN
NC score	0.013620 (rank : 327)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	281	Target Neighborhood Hits	937	Shared Neighborhood Hits	40
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NFAC2_MOUSE
NC score	0.013362 (rank : 328)	θ value	4.03905 (rank : 197)
Query Neighborhood Hits	281	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q60591, Q60984, Q60985	Gene names	Nfatc2, Nfat1, Nfatp
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

MYBB_MOUSE
NC score	0.013281 (rank : 329)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	9
SwissProt Accessions	P48972	Gene names	Mybl2, Bmyb
Domain Architecture
Description	Myb-related protein B (B-Myb).

REN3B_HUMAN
NC score	0.013209 (rank : 330)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	281	Target Neighborhood Hits	412	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

PDE4A_HUMAN
NC score	0.013169 (rank : 331)	θ value	0.813845 (rank : 140)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

RAI14_MOUSE
NC score	0.013148 (rank : 332)	θ value	1.06291 (rank : 146)
Query Neighborhood Hits	281	Target Neighborhood Hits	1505	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ALMS1_MOUSE
NC score	0.012920 (rank : 333)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	281	Target Neighborhood Hits	181	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

COG3_HUMAN
NC score	0.012896 (rank : 334)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	281	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

CP51A_HUMAN
NC score	0.011541 (rank : 335)	θ value	1.81305 (rank : 160)
Query Neighborhood Hits	281	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q16850, O00770, O00772, Q16784, Q8N1A8, Q99868	Gene names	CYP51A1, CYP51
Domain Architecture
Description	Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).

PASK_HUMAN
NC score	0.011393 (rank : 336)	θ value	0.21417 (rank : 113)
Query Neighborhood Hits	281	Target Neighborhood Hits	857	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

SEM6D_MOUSE
NC score	0.011253 (rank : 337)	θ value	5.27518 (rank : 223)
Query Neighborhood Hits	281	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0	Gene names	Sema6d, Kiaa1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

KI21A_HUMAN
NC score	0.011066 (rank : 338)	θ value	1.81305 (rank : 163)
Query Neighborhood Hits	281	Target Neighborhood Hits	1543	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

PLD2_HUMAN
NC score	0.011029 (rank : 339)	θ value	6.88961 (rank : 244)
Query Neighborhood Hits	281	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	O14939, O43540, O43579, O43580, Q96BY3	Gene names	PLD2
Domain Architecture
Description	Phospholipase D2 (EC 3.1.4.4) (PLD 2) (Choline phosphatase 2) (Phosphatidylcholine-hydrolyzing phospholipase D2) (PLD1C) (hPLD2).

ZN438_HUMAN
NC score	0.010545 (rank : 340)	θ value	0.279714 (rank : 120)
Query Neighborhood Hits	281	Target Neighborhood Hits	906	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

SMAL1_HUMAN
NC score	0.010367 (rank : 341)	θ value	6.88961 (rank : 247)
Query Neighborhood Hits	281	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

MAST4_HUMAN
NC score	0.010274 (rank : 342)	θ value	0.62314 (rank : 130)
Query Neighborhood Hits	281	Target Neighborhood Hits	1804	Shared Neighborhood Hits	78
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

KI21A_MOUSE
NC score	0.010218 (rank : 343)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	281	Target Neighborhood Hits	1317	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

UBQL4_MOUSE
NC score	0.010148 (rank : 344)	θ value	6.88961 (rank : 253)
Query Neighborhood Hits	281	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

RBP2_HUMAN
NC score	0.009440 (rank : 345)	θ value	1.38821 (rank : 154)
Query Neighborhood Hits	281	Target Neighborhood Hits	249	Shared Neighborhood Hits	12
SwissProt Accessions	P49792, Q13074, Q15280, Q53TE2, Q59FH7	Gene names	RANBP2, NUP358
Domain Architecture
Description	Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270).

GAK5_HUMAN
NC score	0.008896 (rank : 346)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	281	Target Neighborhood Hits	429	Shared Neighborhood Hits	30
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MOR2B_MOUSE
NC score	0.008671 (rank : 347)	θ value	6.88961 (rank : 242)
Query Neighborhood Hits	281	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C5W4, Q8CG24	Gene names	Morc2b, Tce6
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2B (TCE6).

GRIP2_HUMAN
NC score	0.008559 (rank : 348)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	281	Target Neighborhood Hits	256	Shared Neighborhood Hits	11
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

ADA29_HUMAN
NC score	0.008369 (rank : 349)	θ value	2.36792 (rank : 167)
Query Neighborhood Hits	281	Target Neighborhood Hits	247	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

MYOD1_HUMAN
NC score	0.008260 (rank : 350)	θ value	6.88961 (rank : 243)
Query Neighborhood Hits	281	Target Neighborhood Hits	100	Shared Neighborhood Hits	6
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

SPEG_HUMAN
NC score	0.008229 (rank : 351)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	281	Target Neighborhood Hits	1762	Shared Neighborhood Hits	84
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PASK_MOUSE
NC score	0.008113 (rank : 352)	θ value	0.813845 (rank : 139)
Query Neighborhood Hits	281	Target Neighborhood Hits	867	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

ADA10_MOUSE
NC score	0.007697 (rank : 353)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	281	Target Neighborhood Hits	194	Shared Neighborhood Hits	6
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

NDF1_MOUSE
NC score	0.007645 (rank : 354)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	281	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

MYO9B_HUMAN
NC score	0.007564 (rank : 355)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	281	Target Neighborhood Hits	641	Shared Neighborhood Hits	41
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CSPG3_HUMAN
NC score	0.006990 (rank : 356)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	281	Target Neighborhood Hits	676	Shared Neighborhood Hits	36
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

AMFR2_HUMAN
NC score	0.006937 (rank : 357)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	281	Target Neighborhood Hits	219	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

MYOM1_MOUSE
NC score	0.006739 (rank : 358)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	281	Target Neighborhood Hits	415	Shared Neighborhood Hits	18
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

GDF11_HUMAN
NC score	0.006575 (rank : 359)	θ value	8.99809 (rank : 260)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	O95390, Q9UID1, Q9UID2	Gene names	GDF11, BMP11
Domain Architecture
Description	Growth/differentiation factor 11 precursor (GDF-11) (Bone morphogenetic protein 11).

GDF11_MOUSE
NC score	0.006574 (rank : 360)	θ value	8.99809 (rank : 261)
Query Neighborhood Hits	281	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1W4, Q9QX55, Q9R221	Gene names	Gdf11, Bmp11
Domain Architecture
Description	Growth/differentiation factor 11 precursor (GDF-11) (Bone morphogenetic protein 11).

CPXM2_HUMAN
NC score	0.006250 (rank : 361)	θ value	2.36792 (rank : 173)
Query Neighborhood Hits	281	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N436	Gene names	CPXM2
Domain Architecture
Description	Carboxypeptidase-like protein X2 precursor.

MUG1_MOUSE
NC score	0.005273 (rank : 362)	θ value	8.99809 (rank : 266)
Query Neighborhood Hits	281	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P28665	Gene names	Mug1, Mug-1
Domain Architecture
Description	Murinoglobulin-1 precursor (MuG1).

SEM4D_MOUSE
NC score	0.004724 (rank : 363)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	281	Target Neighborhood Hits	143	Shared Neighborhood Hits	7
SwissProt Accessions	O09126	Gene names	Sema4d, Semacl2, Semaj
Domain Architecture
Description	Semaphorin-4D precursor (Semaphorin J) (Sema J) (Semaphorin C-like 2) (M-Sema G).

CLCN1_HUMAN
NC score	0.004401 (rank : 364)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	281	Target Neighborhood Hits	89	Shared Neighborhood Hits	12
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

MARK2_HUMAN
NC score	0.003717 (rank : 365)	θ value	0.163984 (rank : 109)
Query Neighborhood Hits	281	Target Neighborhood Hits	1056	Shared Neighborhood Hits	39
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PTPRG_MOUSE
NC score	0.003630 (rank : 366)	θ value	5.27518 (rank : 220)
Query Neighborhood Hits	281	Target Neighborhood Hits	260	Shared Neighborhood Hits	17
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

MTR1L_HUMAN
NC score	0.001426 (rank : 367)	θ value	1.38821 (rank : 152)
Query Neighborhood Hits	281	Target Neighborhood Hits	1180	Shared Neighborhood Hits	35
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

M4K4_MOUSE
NC score	0.000548 (rank : 368)	θ value	8.99809 (rank : 264)
Query Neighborhood Hits	281	Target Neighborhood Hits	1560	Shared Neighborhood Hits	45
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

NELL1_HUMAN
NC score	0.000069 (rank : 369)	θ value	4.03905 (rank : 196)
Query Neighborhood Hits	281	Target Neighborhood Hits	451	Shared Neighborhood Hits	10
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

DLX4_MOUSE
NC score	-0.001465 (rank : 370)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	281	Target Neighborhood Hits	352	Shared Neighborhood Hits	7
SwissProt Accessions	P70436, Q3UM51, Q8R4I3	Gene names	Dlx4, Dlx7
Domain Architecture
Description	Homeobox protein DLX-4 (DLX-7).

KSR1_HUMAN
NC score	-0.001510 (rank : 371)	θ value	6.88961 (rank : 235)
Query Neighborhood Hits	281	Target Neighborhood Hits	867	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
NC score	-0.001594 (rank : 372)	θ value	6.88961 (rank : 236)
Query Neighborhood Hits	281	Target Neighborhood Hits	870	Shared Neighborhood Hits	17
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

ZN688_HUMAN
NC score	-0.002866 (rank : 373)	θ value	1.38821 (rank : 157)
Query Neighborhood Hits	281	Target Neighborhood Hits	873	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

RIPK5_MOUSE
NC score	-0.002889 (rank : 374)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	281	Target Neighborhood Hits	874	Shared Neighborhood Hits	16
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

PRDM1_MOUSE
NC score	-0.004216 (rank : 375)	θ value	1.81305 (rank : 166)
Query Neighborhood Hits	281	Target Neighborhood Hits	766	Shared Neighborhood Hits	11
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

UFO_HUMAN
NC score	-0.004871 (rank : 376)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	281	Target Neighborhood Hits	981	Shared Neighborhood Hits	15
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).