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Network neighborhood for query Sequence : RGDSR_HUMAN

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RGDSR_HUMAN
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RGDSR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	63	Target Neighborhood Hits	63	Shared Neighborhood Hits	63
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

GNDS_MOUSE
θ value	4.82422e-78 (rank : 2)	NC score	0.922031 (rank : 2)
Query Neighborhood Hits	63	Target Neighborhood Hits	115	Shared Neighborhood Hits	33
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
θ value	1.22964e-73 (rank : 3)	NC score	0.908356 (rank : 5)
Query Neighborhood Hits	63	Target Neighborhood Hits	201	Shared Neighborhood Hits	36
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
θ value	3.47335e-60 (rank : 4)	NC score	0.914902 (rank : 3)
Query Neighborhood Hits	63	Target Neighborhood Hits	42	Shared Neighborhood Hits	20
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_HUMAN
θ value	1.7238e-59 (rank : 5)	NC score	0.911679 (rank : 4)
Query Neighborhood Hits	63	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_HUMAN
θ value	1.46607e-42 (rank : 6)	NC score	0.892352 (rank : 6)
Query Neighborhood Hits	63	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
θ value	2.11701e-41 (rank : 7)	NC score	0.885532 (rank : 7)
Query Neighborhood Hits	63	Target Neighborhood Hits	51	Shared Neighborhood Hits	20
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNRP_MOUSE
θ value	3.51386e-20 (rank : 8)	NC score	0.552781 (rank : 11)
Query Neighborhood Hits	63	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
θ value	1.13037e-18 (rank : 9)	NC score	0.563524 (rank : 10)
Query Neighborhood Hits	63	Target Neighborhood Hits	239	Shared Neighborhood Hits	21
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RPGF1_HUMAN
θ value	1.92812e-18 (rank : 10)	NC score	0.657855 (rank : 8)
Query Neighborhood Hits	63	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS1_HUMAN
θ value	2.43908e-13 (rank : 11)	NC score	0.547561 (rank : 13)
Query Neighborhood Hits	63	Target Neighborhood Hits	274	Shared Neighborhood Hits	34
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	3.18553e-13 (rank : 12)	NC score	0.551250 (rank : 12)
Query Neighborhood Hits	63	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	2.69671e-12 (rank : 13)	NC score	0.568697 (rank : 9)
Query Neighborhood Hits	63	Target Neighborhood Hits	193	Shared Neighborhood Hits	25
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

RPGF6_HUMAN
θ value	1.69304e-06 (rank : 14)	NC score	0.425920 (rank : 15)
Query Neighborhood Hits	63	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

CB027_HUMAN
θ value	2.21117e-06 (rank : 15)	NC score	0.209783 (rank : 23)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

RPGF2_HUMAN
θ value	0.000121331 (rank : 16)	NC score	0.436758 (rank : 14)
Query Neighborhood Hits	63	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF4_HUMAN
θ value	0.00509761 (rank : 17)	NC score	0.358266 (rank : 19)
Query Neighborhood Hits	63	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

MUC1_HUMAN
θ value	0.00869519 (rank : 18)	NC score	0.053249 (rank : 37)
Query Neighborhood Hits	63	Target Neighborhood Hits	975	Shared Neighborhood Hits	28
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

OGFR_HUMAN
θ value	0.00869519 (rank : 19)	NC score	0.063468 (rank : 29)
Query Neighborhood Hits	63	Target Neighborhood Hits	1582	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RPGF4_MOUSE
θ value	0.0113563 (rank : 20)	NC score	0.353475 (rank : 20)
Query Neighborhood Hits	63	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

SON_HUMAN
θ value	0.0252991 (rank : 21)	NC score	0.068267 (rank : 26)
Query Neighborhood Hits	63	Target Neighborhood Hits	1568	Shared Neighborhood Hits	33
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CO039_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.085822 (rank : 24)
Query Neighborhood Hits	63	Target Neighborhood Hits	264	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CSPG5_MOUSE
θ value	0.0431538 (rank : 23)	NC score	0.066809 (rank : 27)
Query Neighborhood Hits	63	Target Neighborhood Hits	211	Shared Neighborhood Hits	9
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

NRX2A_HUMAN
θ value	0.0431538 (rank : 24)	NC score	0.037755 (rank : 48)
Query Neighborhood Hits	63	Target Neighborhood Hits	614	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.0431538 (rank : 25)	NC score	0.052933 (rank : 39)
Query Neighborhood Hits	63	Target Neighborhood Hits	481	Shared Neighborhood Hits	16
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

RPGF5_MOUSE
θ value	0.0431538 (rank : 26)	NC score	0.385196 (rank : 18)
Query Neighborhood Hits	63	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	0.0563607 (rank : 27)	NC score	0.398258 (rank : 17)
Query Neighborhood Hits	63	Target Neighborhood Hits	42	Shared Neighborhood Hits	20
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RGS3_MOUSE
θ value	0.0961366 (rank : 28)	NC score	0.054708 (rank : 34)
Query Neighborhood Hits	63	Target Neighborhood Hits	1621	Shared Neighborhood Hits	35
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RPGF3_HUMAN
θ value	0.163984 (rank : 29)	NC score	0.308207 (rank : 21)
Query Neighborhood Hits	63	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

BCL9_HUMAN
θ value	0.279714 (rank : 30)	NC score	0.064599 (rank : 28)
Query Neighborhood Hits	63	Target Neighborhood Hits	1008	Shared Neighborhood Hits	30
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

K1543_MOUSE
θ value	0.279714 (rank : 31)	NC score	0.053057 (rank : 38)
Query Neighborhood Hits	63	Target Neighborhood Hits	497	Shared Neighborhood Hits	24
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

ZIMP7_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.042705 (rank : 44)
Query Neighborhood Hits	63	Target Neighborhood Hits	566	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

NFH_MOUSE
θ value	0.365318 (rank : 33)	NC score	0.032530 (rank : 51)
Query Neighborhood Hits	63	Target Neighborhood Hits	2247	Shared Neighborhood Hits	30
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CTBP2_HUMAN
θ value	0.47712 (rank : 34)	NC score	0.035221 (rank : 50)
Query Neighborhood Hits	63	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P56545, O43449	Gene names	CTBP2
Domain Architecture
Description	C-terminal-binding protein 2 (CtBP2).

MINT_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.036663 (rank : 49)
Query Neighborhood Hits	63	Target Neighborhood Hits	1291	Shared Neighborhood Hits	26
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

TBX21_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.016118 (rank : 65)
Query Neighborhood Hits	63	Target Neighborhood Hits	146	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

ARMX2_MOUSE
θ value	0.813845 (rank : 37)	NC score	0.044051 (rank : 43)
Query Neighborhood Hits	63	Target Neighborhood Hits	349	Shared Neighborhood Hits	15
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

SOX13_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.029440 (rank : 57)
Query Neighborhood Hits	63	Target Neighborhood Hits	464	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

JIP3_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.021127 (rank : 63)
Query Neighborhood Hits	63	Target Neighborhood Hits	1039	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

M3K14_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.003646 (rank : 72)
Query Neighborhood Hits	63	Target Neighborhood Hits	889	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MKL1_MOUSE
θ value	1.38821 (rank : 41)	NC score	0.038325 (rank : 47)
Query Neighborhood Hits	63	Target Neighborhood Hits	667	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

ZFPL1_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.031920 (rank : 53)
Query Neighborhood Hits	63	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O95159, O14616, Q9UID0	Gene names	ZFPL1
Domain Architecture	No domain graphic available
Description	Zinc finger protein-like 1 (Zinc finger protein MCG4).

BAG4_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.027977 (rank : 58)
Query Neighborhood Hits	63	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CI61, Q3TRL9, Q91VT5, Q9CWG2	Gene names	Bag4, Sodd
Domain Architecture
Description	BAG family molecular chaperone regulator 4 (BCL2-associated athanogene 4) (BAG-4) (Silencer of death domains).

CSPG5_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.058440 (rank : 32)
Query Neighborhood Hits	63	Target Neighborhood Hits	199	Shared Neighborhood Hits	9
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

CTBP2_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.031031 (rank : 55)
Query Neighborhood Hits	63	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P56546, O54855, O88462	Gene names	Ctbp2
Domain Architecture
Description	C-terminal-binding protein 2 (CtBP2).

K1802_MOUSE
θ value	1.81305 (rank : 46)	NC score	0.027353 (rank : 59)
Query Neighborhood Hits	63	Target Neighborhood Hits	1596	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NELL2_HUMAN
θ value	1.81305 (rank : 47)	NC score	0.005302 (rank : 71)
Query Neighborhood Hits	63	Target Neighborhood Hits	449	Shared Neighborhood Hits	2
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

RXRA_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.006687 (rank : 70)
Query Neighborhood Hits	63	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

BCL9_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.059945 (rank : 30)
Query Neighborhood Hits	63	Target Neighborhood Hits	770	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

RERE_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.041755 (rank : 45)
Query Neighborhood Hits	63	Target Neighborhood Hits	785	Shared Neighborhood Hits	28
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TNR8_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.032040 (rank : 52)
Query Neighborhood Hits	63	Target Neighborhood Hits	208	Shared Neighborhood Hits	6
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

LMO6_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.009187 (rank : 69)
Query Neighborhood Hits	63	Target Neighborhood Hits	277	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VL3, Q8CAY9	Gene names	Lmo6
Domain Architecture	No domain graphic available
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

PCLO_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.030023 (rank : 56)
Query Neighborhood Hits	63	Target Neighborhood Hits	2275	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

STAT2_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.059728 (rank : 31)
Query Neighborhood Hits	63	Target Neighborhood Hits	175	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

MAP2_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.019311 (rank : 64)
Query Neighborhood Hits	63	Target Neighborhood Hits	348	Shared Neighborhood Hits	11
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

PELP1_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.041142 (rank : 46)
Query Neighborhood Hits	63	Target Neighborhood Hits	709	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

TCF7_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.014228 (rank : 67)
Query Neighborhood Hits	63	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

SOX30_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.022602 (rank : 60)
Query Neighborhood Hits	63	Target Neighborhood Hits	374	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

DFNA5_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.012980 (rank : 68)
Query Neighborhood Hits	63	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2D3	Gene names	Dfna5, Dfna5h
Domain Architecture
Description	Non-syndromic hearing impairment protein 5 homolog.

NFAC1_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.021269 (rank : 62)
Query Neighborhood Hits	63	Target Neighborhood Hits	312	Shared Neighborhood Hits	14
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

PSL1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.015926 (rank : 66)
Query Neighborhood Hits	63	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RGS3_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.031674 (rank : 54)
Query Neighborhood Hits	63	Target Neighborhood Hits	1375	Shared Neighborhood Hits	26
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TCGAP_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.021683 (rank : 61)
Query Neighborhood Hits	63	Target Neighborhood Hits	872	Shared Neighborhood Hits	26
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CO039_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.053442 (rank : 36)
Query Neighborhood Hits	63	Target Neighborhood Hits	445	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

ECT2_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.056352 (rank : 33)
Query Neighborhood Hits	63	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.053685 (rank : 35)
Query Neighborhood Hits	63	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

GRP3_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.417117 (rank : 16)
Query Neighborhood Hits	63	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PREX1_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.068681 (rank : 25)
Query Neighborhood Hits	63	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP2_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.051214 (rank : 41)
Query Neighborhood Hits	63	Target Neighborhood Hits	347	Shared Neighborhood Hits	23
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

RPGF3_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.261511 (rank : 22)
Query Neighborhood Hits	63	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

SELPL_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.051795 (rank : 40)
Query Neighborhood Hits	63	Target Neighborhood Hits	588	Shared Neighborhood Hits	19
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SON_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.051189 (rank : 42)
Query Neighborhood Hits	63	Target Neighborhood Hits	957	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

Hits sorted by NC score

RGDSR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	63	Target Neighborhood Hits	63	Shared Neighborhood Hits	63
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

GNDS_MOUSE
NC score	0.922031 (rank : 2)	θ value	4.82422e-78 (rank : 2)
Query Neighborhood Hits	63	Target Neighborhood Hits	115	Shared Neighborhood Hits	33
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
NC score	0.914902 (rank : 3)	θ value	3.47335e-60 (rank : 4)
Query Neighborhood Hits	63	Target Neighborhood Hits	42	Shared Neighborhood Hits	20
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_HUMAN
NC score	0.911679 (rank : 4)	θ value	1.7238e-59 (rank : 5)
Query Neighborhood Hits	63	Target Neighborhood Hits	43	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_HUMAN
NC score	0.908356 (rank : 5)	θ value	1.22964e-73 (rank : 3)
Query Neighborhood Hits	63	Target Neighborhood Hits	201	Shared Neighborhood Hits	36
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
NC score	0.892352 (rank : 6)	θ value	1.46607e-42 (rank : 6)
Query Neighborhood Hits	63	Target Neighborhood Hits	45	Shared Neighborhood Hits	22
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
NC score	0.885532 (rank : 7)	θ value	2.11701e-41 (rank : 7)
Query Neighborhood Hits	63	Target Neighborhood Hits	51	Shared Neighborhood Hits	20
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RPGF1_HUMAN
NC score	0.657855 (rank : 8)	θ value	1.92812e-18 (rank : 10)
Query Neighborhood Hits	63	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS2_HUMAN
NC score	0.568697 (rank : 9)	θ value	2.69671e-12 (rank : 13)
Query Neighborhood Hits	63	Target Neighborhood Hits	193	Shared Neighborhood Hits	25
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_HUMAN
NC score	0.563524 (rank : 10)	θ value	1.13037e-18 (rank : 9)
Query Neighborhood Hits	63	Target Neighborhood Hits	239	Shared Neighborhood Hits	21
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.552781 (rank : 11)	θ value	3.51386e-20 (rank : 8)
Query Neighborhood Hits	63	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
NC score	0.551250 (rank : 12)	θ value	3.18553e-13 (rank : 12)
Query Neighborhood Hits	63	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.547561 (rank : 13)	θ value	2.43908e-13 (rank : 11)
Query Neighborhood Hits	63	Target Neighborhood Hits	274	Shared Neighborhood Hits	34
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

RPGF2_HUMAN
NC score	0.436758 (rank : 14)	θ value	0.000121331 (rank : 16)
Query Neighborhood Hits	63	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.425920 (rank : 15)	θ value	1.69304e-06 (rank : 14)
Query Neighborhood Hits	63	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GRP3_HUMAN
NC score	0.417117 (rank : 16)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	63	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF5_HUMAN
NC score	0.398258 (rank : 17)	θ value	0.0563607 (rank : 27)
Query Neighborhood Hits	63	Target Neighborhood Hits	42	Shared Neighborhood Hits	20
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
NC score	0.385196 (rank : 18)	θ value	0.0431538 (rank : 26)
Query Neighborhood Hits	63	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.358266 (rank : 19)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	63	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.353475 (rank : 20)	θ value	0.0113563 (rank : 20)
Query Neighborhood Hits	63	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.308207 (rank : 21)	θ value	0.163984 (rank : 29)
Query Neighborhood Hits	63	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.261511 (rank : 22)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	63	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

CB027_HUMAN
NC score	0.209783 (rank : 23)	θ value	2.21117e-06 (rank : 15)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

CO039_HUMAN
NC score	0.085822 (rank : 24)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	63	Target Neighborhood Hits	264	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

PREX1_HUMAN
NC score	0.068681 (rank : 25)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	63	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SON_HUMAN
NC score	0.068267 (rank : 26)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	63	Target Neighborhood Hits	1568	Shared Neighborhood Hits	33
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CSPG5_MOUSE
NC score	0.066809 (rank : 27)	θ value	0.0431538 (rank : 23)
Query Neighborhood Hits	63	Target Neighborhood Hits	211	Shared Neighborhood Hits	9
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

BCL9_HUMAN
NC score	0.064599 (rank : 28)	θ value	0.279714 (rank : 30)
Query Neighborhood Hits	63	Target Neighborhood Hits	1008	Shared Neighborhood Hits	30
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

OGFR_HUMAN
NC score	0.063468 (rank : 29)	θ value	0.00869519 (rank : 19)
Query Neighborhood Hits	63	Target Neighborhood Hits	1582	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

BCL9_MOUSE
NC score	0.059945 (rank : 30)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	63	Target Neighborhood Hits	770	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

STAT2_MOUSE
NC score	0.059728 (rank : 31)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	63	Target Neighborhood Hits	175	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

CSPG5_HUMAN
NC score	0.058440 (rank : 32)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	63	Target Neighborhood Hits	199	Shared Neighborhood Hits	9
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

ECT2_HUMAN
NC score	0.056352 (rank : 33)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	63	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RGS3_MOUSE
NC score	0.054708 (rank : 34)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	63	Target Neighborhood Hits	1621	Shared Neighborhood Hits	35
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ECT2_MOUSE
NC score	0.053685 (rank : 35)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	63	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

CO039_MOUSE
NC score	0.053442 (rank : 36)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	63	Target Neighborhood Hits	445	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

MUC1_HUMAN
NC score	0.053249 (rank : 37)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	63	Target Neighborhood Hits	975	Shared Neighborhood Hits	28
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

K1543_MOUSE
NC score	0.053057 (rank : 38)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	63	Target Neighborhood Hits	497	Shared Neighborhood Hits	24
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

NRX2B_HUMAN
NC score	0.052933 (rank : 39)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	63	Target Neighborhood Hits	481	Shared Neighborhood Hits	16
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

SELPL_MOUSE
NC score	0.051795 (rank : 40)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	63	Target Neighborhood Hits	588	Shared Neighborhood Hits	19
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

PRP2_MOUSE
NC score	0.051214 (rank : 41)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	63	Target Neighborhood Hits	347	Shared Neighborhood Hits	23
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SON_MOUSE
NC score	0.051189 (rank : 42)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	63	Target Neighborhood Hits	957	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

ARMX2_MOUSE
NC score	0.044051 (rank : 43)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	63	Target Neighborhood Hits	349	Shared Neighborhood Hits	15
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

ZIMP7_MOUSE
NC score	0.042705 (rank : 44)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	63	Target Neighborhood Hits	566	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

RERE_MOUSE
NC score	0.041755 (rank : 45)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	63	Target Neighborhood Hits	785	Shared Neighborhood Hits	28
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

PELP1_MOUSE
NC score	0.041142 (rank : 46)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	63	Target Neighborhood Hits	709	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

MKL1_MOUSE
NC score	0.038325 (rank : 47)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	63	Target Neighborhood Hits	667	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NRX2A_HUMAN
NC score	0.037755 (rank : 48)	θ value	0.0431538 (rank : 24)
Query Neighborhood Hits	63	Target Neighborhood Hits	614	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

MINT_HUMAN
NC score	0.036663 (rank : 49)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	63	Target Neighborhood Hits	1291	Shared Neighborhood Hits	26
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CTBP2_HUMAN
NC score	0.035221 (rank : 50)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	63	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P56545, O43449	Gene names	CTBP2
Domain Architecture
Description	C-terminal-binding protein 2 (CtBP2).

NFH_MOUSE
NC score	0.032530 (rank : 51)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	63	Target Neighborhood Hits	2247	Shared Neighborhood Hits	30
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TNR8_MOUSE
NC score	0.032040 (rank : 52)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	63	Target Neighborhood Hits	208	Shared Neighborhood Hits	6
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

ZFPL1_HUMAN
NC score	0.031920 (rank : 53)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	63	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O95159, O14616, Q9UID0	Gene names	ZFPL1
Domain Architecture	No domain graphic available
Description	Zinc finger protein-like 1 (Zinc finger protein MCG4).

RGS3_HUMAN
NC score	0.031674 (rank : 54)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	63	Target Neighborhood Hits	1375	Shared Neighborhood Hits	26
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CTBP2_MOUSE
NC score	0.031031 (rank : 55)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	63	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P56546, O54855, O88462	Gene names	Ctbp2
Domain Architecture
Description	C-terminal-binding protein 2 (CtBP2).

PCLO_MOUSE
NC score	0.030023 (rank : 56)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	63	Target Neighborhood Hits	2275	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SOX13_HUMAN
NC score	0.029440 (rank : 57)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	63	Target Neighborhood Hits	464	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

BAG4_MOUSE
NC score	0.027977 (rank : 58)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	63	Target Neighborhood Hits	79	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CI61, Q3TRL9, Q91VT5, Q9CWG2	Gene names	Bag4, Sodd
Domain Architecture
Description	BAG family molecular chaperone regulator 4 (BCL2-associated athanogene 4) (BAG-4) (Silencer of death domains).

K1802_MOUSE
NC score	0.027353 (rank : 59)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	63	Target Neighborhood Hits	1596	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SOX30_MOUSE
NC score	0.022602 (rank : 60)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	63	Target Neighborhood Hits	374	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

TCGAP_HUMAN
NC score	0.021683 (rank : 61)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	63	Target Neighborhood Hits	872	Shared Neighborhood Hits	26
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NFAC1_HUMAN
NC score	0.021269 (rank : 62)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	63	Target Neighborhood Hits	312	Shared Neighborhood Hits	14
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

JIP3_HUMAN
NC score	0.021127 (rank : 63)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	63	Target Neighborhood Hits	1039	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

MAP2_HUMAN
NC score	0.019311 (rank : 64)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	63	Target Neighborhood Hits	348	Shared Neighborhood Hits	11
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

TBX21_HUMAN
NC score	0.016118 (rank : 65)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	63	Target Neighborhood Hits	146	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

PSL1_HUMAN
NC score	0.015926 (rank : 66)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	63	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

TCF7_MOUSE
NC score	0.014228 (rank : 67)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	63	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

DFNA5_MOUSE
NC score	0.012980 (rank : 68)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	63	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2D3	Gene names	Dfna5, Dfna5h
Domain Architecture
Description	Non-syndromic hearing impairment protein 5 homolog.

LMO6_MOUSE
NC score	0.009187 (rank : 69)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	63	Target Neighborhood Hits	277	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VL3, Q8CAY9	Gene names	Lmo6
Domain Architecture	No domain graphic available
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

RXRA_HUMAN
NC score	0.006687 (rank : 70)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	63	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

NELL2_HUMAN
NC score	0.005302 (rank : 71)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	63	Target Neighborhood Hits	449	Shared Neighborhood Hits	2
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

M3K14_MOUSE
NC score	0.003646 (rank : 72)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	63	Target Neighborhood Hits	889	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).