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Network neighborhood for query Sequence : RPGF5_MOUSE

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RPGF5_MOUSE
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RPGF5_HUMAN
θ value	0 (rank : 1)	NC score	0.989613 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	30
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
θ value	3.36238e-172 (rank : 3)	NC score	0.936001 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	2.03989e-169 (rank : 4)	NC score	0.935258 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	80	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
θ value	2.1455e-110 (rank : 5)	NC score	0.912210 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	56	Shared Neighborhood Hits	25
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	4.77967e-110 (rank : 6)	NC score	0.905004 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF2_HUMAN
θ value	1.2411e-41 (rank : 7)	NC score	0.734343 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	242	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	1.51715e-39 (rank : 8)	NC score	0.700217 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GNRP_HUMAN
θ value	4.01107e-24 (rank : 9)	NC score	0.562974 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RPGF1_HUMAN
θ value	5.23862e-24 (rank : 10)	NC score	0.743255 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GNRP_MOUSE
θ value	6.40375e-22 (rank : 11)	NC score	0.547499 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	191	Shared Neighborhood Hits	27
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
θ value	9.56915e-18 (rank : 12)	NC score	0.548563 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	281	Shared Neighborhood Hits	24
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
θ value	3.63628e-17 (rank : 13)	NC score	0.548143 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
θ value	1.52774e-15 (rank : 14)	NC score	0.562225 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GRP3_HUMAN
θ value	1.2105e-12 (rank : 15)	NC score	0.526592 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	131	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RGL1_HUMAN
θ value	1.80886e-08 (rank : 16)	NC score	0.499415 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_HUMAN
θ value	8.97725e-08 (rank : 17)	NC score	0.456466 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	201	Shared Neighborhood Hits	23
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_MOUSE
θ value	1.99992e-07 (rank : 18)	NC score	0.470939 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
θ value	1.99992e-07 (rank : 19)	NC score	0.468419 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_MOUSE
θ value	3.77169e-06 (rank : 20)	NC score	0.459475 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
θ value	5.44631e-05 (rank : 21)	NC score	0.451377 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

PREX1_HUMAN
θ value	0.000121331 (rank : 22)	NC score	0.179406 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SH2D3_MOUSE
θ value	0.00035302 (rank : 23)	NC score	0.149813 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	174	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH2D3_HUMAN
θ value	0.00102713 (rank : 24)	NC score	0.141636 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

RGDSR_HUMAN
θ value	0.0431538 (rank : 25)	NC score	0.385196 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

SAS6_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.051304 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	791	Shared Neighborhood Hits	28
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

FYV1_MOUSE
θ value	0.0961366 (rank : 27)	NC score	0.085251 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

SAS6_MOUSE
θ value	0.163984 (rank : 28)	NC score	0.044086 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	931	Shared Neighborhood Hits	32
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

EEA1_HUMAN
θ value	0.21417 (rank : 29)	NC score	0.027728 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	1796	Shared Neighborhood Hits	37
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FYV1_HUMAN
θ value	0.21417 (rank : 30)	NC score	0.083362 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	217	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

DHX16_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.014812 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	356	Shared Neighborhood Hits	12
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

NUCL_MOUSE
θ value	0.365318 (rank : 32)	NC score	0.019121 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	425	Shared Neighborhood Hits	5
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

BLNK_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.039817 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	228	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

DEPD5_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.058509 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

ERC2_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.026527 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	1156	Shared Neighborhood Hits	29
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	0.62314 (rank : 36)	NC score	0.026485 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	1166	Shared Neighborhood Hits	29
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

MYH3_HUMAN
θ value	0.62314 (rank : 37)	NC score	0.025401 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	1660	Shared Neighborhood Hits	36
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

CEP35_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.034887 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	811	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

ROCK2_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.009220 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	2073	Shared Neighborhood Hits	36
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

TMCC3_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.020887 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULS5, Q8IWB2	Gene names	TMCC3, KIAA1145
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 3.

CP250_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.022665 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	1583	Shared Neighborhood Hits	38
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MYH8_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.024934 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	1600	Shared Neighborhood Hits	33
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RBM19_HUMAN
θ value	1.06291 (rank : 43)	NC score	0.013075 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	331	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4C8, Q9BPY6, Q9UFN5	Gene names	RBM19, KIAA0682
Domain Architecture
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

HOOK3_HUMAN
θ value	1.38821 (rank : 44)	NC score	0.023547 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	1070	Shared Neighborhood Hits	30
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK3_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.025268 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	1007	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

MYH6_MOUSE
θ value	1.38821 (rank : 46)	NC score	0.027544 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	1501	Shared Neighborhood Hits	37
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

DVL1L_HUMAN
θ value	1.81305 (rank : 47)	NC score	0.050531 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	146	Shared Neighborhood Hits	15
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

GP155_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.141958 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

MYH6_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.026633 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	1426	Shared Neighborhood Hits	36
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

TPM4_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.025019 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	703	Shared Neighborhood Hits	28
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

DAAM2_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.016159 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DVL1_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.053662 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	146	Shared Neighborhood Hits	15
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

FLIP1_HUMAN
θ value	2.36792 (rank : 53)	NC score	0.019777 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	1405	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

MYH2_HUMAN
θ value	2.36792 (rank : 54)	NC score	0.024421 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	1491	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

DVL2_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.042198 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	223	Shared Neighborhood Hits	15
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	3.0926 (rank : 56)	NC score	0.042051 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	233	Shared Neighborhood Hits	15
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

LRC8D_HUMAN
θ value	3.0926 (rank : 57)	NC score	0.006528 (rank : 95)
Query Neighborhood Hits	85	Target Neighborhood Hits	282	Shared Neighborhood Hits	3
SwissProt Accessions	Q7L1W4, Q6UWB2, Q9NVW3	Gene names	LRRC8D, LRRC5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

LRC8D_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.006498 (rank : 96)
Query Neighborhood Hits	85	Target Neighborhood Hits	284	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGR2, Q3UVA9, Q8CI13	Gene names	Lrrc8d, Lrrc5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

MYH9_MOUSE
θ value	3.0926 (rank : 59)	NC score	0.022403 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	1829	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

DDX41_MOUSE
θ value	4.03905 (rank : 60)	NC score	0.003282 (rank : 97)
Query Neighborhood Hits	85	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

HD_MOUSE
θ value	4.03905 (rank : 61)	NC score	0.012307 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P42859	Gene names	Hd, Hdh
Domain Architecture
Description	Huntingtin (Huntington disease protein homolog) (HD protein).

MYH8_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.024106 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	1610	Shared Neighborhood Hits	35
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

NFM_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.011822 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	1328	Shared Neighborhood Hits	35
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NUCL_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.013676 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	415	Shared Neighborhood Hits	6
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

FBX43_MOUSE
θ value	5.27518 (rank : 65)	NC score	0.012780 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CDI2, Q4G0C8, Q8R0R1	Gene names	Fbxo43, Emi2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

GBP5_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.011564 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFB4, Q8CFA4	Gene names	Gbp5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (MuGBP-5).

KTN1_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.021756 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	1324	Shared Neighborhood Hits	33
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MYH4_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.024341 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	1377	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
θ value	5.27518 (rank : 69)	NC score	0.024184 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	1476	Shared Neighborhood Hits	33
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

PRLR_HUMAN
θ value	5.27518 (rank : 70)	NC score	0.008818 (rank : 93)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

RASF7_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.014672 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	Q02833	Gene names	RASSF7, C11orf13, HRC1
Domain Architecture
Description	Ras association domain-containing protein 7 (HRAS1-related cluster protein 1).

APBA2_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.011966 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	220	Shared Neighborhood Hits	10
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.011971 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

CFLAR_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.009391 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

DIAP2_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.011366 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	342	Shared Neighborhood Hits	17
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

DVL1_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.047484 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	158	Shared Neighborhood Hits	14
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

NEK2_MOUSE
θ value	6.88961 (rank : 77)	NC score	-0.001846 (rank : 99)
Query Neighborhood Hits	85	Target Neighborhood Hits	876	Shared Neighborhood Hits	4
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

RUFY2_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.019686 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	1208	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

UT14C_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.009308 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TAP6, Q5FWG3, Q92555	Gene names	UTP14C, KIAA0266
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog C.

BRE1B_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.018097 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	970	Shared Neighborhood Hits	30
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

EP400_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.003161 (rank : 98)
Query Neighborhood Hits	85	Target Neighborhood Hits	592	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

PHF12_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.007113 (rank : 94)
Query Neighborhood Hits	85	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

REST_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.020201 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	1506	Shared Neighborhood Hits	35
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

VDP_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.019455 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	469	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

ZN291_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.017518 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	647	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

ARHG4_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.050085 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BCAR3_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.055397 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CT152_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.193876 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.163377 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

ECT2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.053866 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.051704 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

KAP0_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.092497 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.092701 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.110777 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.108171 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.083442 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.084684 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.082947 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.083512 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

Hits sorted by NC score

RPGF5_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
NC score	0.989613 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	30
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.936001 (rank : 3)	θ value	3.36238e-172 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	88	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.935258 (rank : 4)	θ value	2.03989e-169 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	80	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.912210 (rank : 5)	θ value	2.1455e-110 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	56	Shared Neighborhood Hits	25
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.905004 (rank : 6)	θ value	4.77967e-110 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF1_HUMAN
NC score	0.743255 (rank : 7)	θ value	5.23862e-24 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF2_HUMAN
NC score	0.734343 (rank : 8)	θ value	1.2411e-41 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	242	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.700217 (rank : 9)	θ value	1.51715e-39 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	266	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GNRP_HUMAN
NC score	0.562974 (rank : 10)	θ value	4.01107e-24 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS2_HUMAN
NC score	0.562225 (rank : 11)	θ value	1.52774e-15 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
NC score	0.548563 (rank : 12)	θ value	9.56915e-18 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	281	Shared Neighborhood Hits	24
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.548143 (rank : 13)	θ value	3.63628e-17 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GNRP_MOUSE
NC score	0.547499 (rank : 14)	θ value	6.40375e-22 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	191	Shared Neighborhood Hits	27
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRP3_HUMAN
NC score	0.526592 (rank : 15)	θ value	1.2105e-12 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	131	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RGL1_HUMAN
NC score	0.499415 (rank : 16)	θ value	1.80886e-08 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.470939 (rank : 17)	θ value	1.99992e-07 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
NC score	0.468419 (rank : 18)	θ value	1.99992e-07 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_MOUSE
NC score	0.459475 (rank : 19)	θ value	3.77169e-06 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_HUMAN
NC score	0.456466 (rank : 20)	θ value	8.97725e-08 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	201	Shared Neighborhood Hits	23
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
NC score	0.451377 (rank : 21)	θ value	5.44631e-05 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGDSR_HUMAN
NC score	0.385196 (rank : 22)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

CT152_HUMAN
NC score	0.193876 (rank : 23)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

PREX1_HUMAN
NC score	0.179406 (rank : 24)	θ value	0.000121331 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CT152_MOUSE
NC score	0.163377 (rank : 25)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

SH2D3_MOUSE
NC score	0.149813 (rank : 26)	θ value	0.00035302 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	174	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

GP155_HUMAN
NC score	0.141958 (rank : 27)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

SH2D3_HUMAN
NC score	0.141636 (rank : 28)	θ value	0.00102713 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

KAP1_HUMAN
NC score	0.110777 (rank : 29)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.108171 (rank : 30)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	85	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.092701 (rank : 31)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	85	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP0_HUMAN
NC score	0.092497 (rank : 32)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

FYV1_MOUSE
NC score	0.085251 (rank : 33)	θ value	0.0961366 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

KAP2_MOUSE
NC score	0.084684 (rank : 34)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	85	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.083512 (rank : 35)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	85	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_HUMAN
NC score	0.083442 (rank : 36)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	85	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

FYV1_HUMAN
NC score	0.083362 (rank : 37)	θ value	0.21417 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	217	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

KAP3_HUMAN
NC score	0.082947 (rank : 38)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	85	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

DEPD5_HUMAN
NC score	0.058509 (rank : 39)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

BCAR3_MOUSE
NC score	0.055397 (rank : 40)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ECT2_HUMAN
NC score	0.053866 (rank : 41)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

DVL1_MOUSE
NC score	0.053662 (rank : 42)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	146	Shared Neighborhood Hits	15
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

ECT2_MOUSE
NC score	0.051704 (rank : 43)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SAS6_HUMAN
NC score	0.051304 (rank : 44)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	791	Shared Neighborhood Hits	28
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

DVL1L_HUMAN
NC score	0.050531 (rank : 45)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	146	Shared Neighborhood Hits	15
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

ARHG4_HUMAN
NC score	0.050085 (rank : 46)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DVL1_HUMAN
NC score	0.047484 (rank : 47)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	158	Shared Neighborhood Hits	14
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

SAS6_MOUSE
NC score	0.044086 (rank : 48)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	931	Shared Neighborhood Hits	32
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

DVL2_HUMAN
NC score	0.042198 (rank : 49)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	223	Shared Neighborhood Hits	15
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.042051 (rank : 50)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	233	Shared Neighborhood Hits	15
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

BLNK_HUMAN
NC score	0.039817 (rank : 51)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	228	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CEP35_HUMAN
NC score	0.034887 (rank : 52)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	811	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

EEA1_HUMAN
NC score	0.027728 (rank : 53)	θ value	0.21417 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	1796	Shared Neighborhood Hits	37
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

MYH6_MOUSE
NC score	0.027544 (rank : 54)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	1501	Shared Neighborhood Hits	37
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_HUMAN
NC score	0.026633 (rank : 55)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	1426	Shared Neighborhood Hits	36
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

ERC2_HUMAN
NC score	0.026527 (rank : 56)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	1156	Shared Neighborhood Hits	29
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
NC score	0.026485 (rank : 57)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	1166	Shared Neighborhood Hits	29
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

MYH3_HUMAN
NC score	0.025401 (rank : 58)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	1660	Shared Neighborhood Hits	36
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

HOOK3_MOUSE
NC score	0.025268 (rank : 59)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	1007	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

TPM4_MOUSE
NC score	0.025019 (rank : 60)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	703	Shared Neighborhood Hits	28
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

MYH8_MOUSE
NC score	0.024934 (rank : 61)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	1600	Shared Neighborhood Hits	33
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH2_HUMAN
NC score	0.024421 (rank : 62)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	1491	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH4_HUMAN
NC score	0.024341 (rank : 63)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	1377	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
NC score	0.024184 (rank : 64)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	1476	Shared Neighborhood Hits	33
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH8_HUMAN
NC score	0.024106 (rank : 65)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	1610	Shared Neighborhood Hits	35
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

HOOK3_HUMAN
NC score	0.023547 (rank : 66)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	1070	Shared Neighborhood Hits	30
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

CP250_MOUSE
NC score	0.022665 (rank : 67)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	1583	Shared Neighborhood Hits	38
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MYH9_MOUSE
NC score	0.022403 (rank : 68)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	1829	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

KTN1_MOUSE
NC score	0.021756 (rank : 69)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	1324	Shared Neighborhood Hits	33
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

TMCC3_HUMAN
NC score	0.020887 (rank : 70)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULS5, Q8IWB2	Gene names	TMCC3, KIAA1145
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 3.

REST_MOUSE
NC score	0.020201 (rank : 71)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	1506	Shared Neighborhood Hits	35
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

FLIP1_HUMAN
NC score	0.019777 (rank : 72)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	1405	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

RUFY2_HUMAN
NC score	0.019686 (rank : 73)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	1208	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

VDP_MOUSE
NC score	0.019455 (rank : 74)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	469	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

NUCL_MOUSE
NC score	0.019121 (rank : 75)	θ value	0.365318 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	425	Shared Neighborhood Hits	5
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

BRE1B_MOUSE
NC score	0.018097 (rank : 76)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	970	Shared Neighborhood Hits	30
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

ZN291_HUMAN
NC score	0.017518 (rank : 77)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	647	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

DAAM2_HUMAN
NC score	0.016159 (rank : 78)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DHX16_HUMAN
NC score	0.014812 (rank : 79)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	356	Shared Neighborhood Hits	12
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

RASF7_HUMAN
NC score	0.014672 (rank : 80)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	Q02833	Gene names	RASSF7, C11orf13, HRC1
Domain Architecture
Description	Ras association domain-containing protein 7 (HRAS1-related cluster protein 1).

NUCL_HUMAN
NC score	0.013676 (rank : 81)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	415	Shared Neighborhood Hits	6
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

RBM19_HUMAN
NC score	0.013075 (rank : 82)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	331	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4C8, Q9BPY6, Q9UFN5	Gene names	RBM19, KIAA0682
Domain Architecture
Description	Probable RNA-binding protein 19 (RNA-binding motif protein 19).

FBX43_MOUSE
NC score	0.012780 (rank : 83)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CDI2, Q4G0C8, Q8R0R1	Gene names	Fbxo43, Emi2
Domain Architecture	No domain graphic available
Description	F-box only protein 43 (Endogenous meiotic inhibitor 2).

HD_MOUSE
NC score	0.012307 (rank : 84)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P42859	Gene names	Hd, Hdh
Domain Architecture
Description	Huntingtin (Huntington disease protein homolog) (HD protein).

APBA2_MOUSE
NC score	0.011971 (rank : 85)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.011966 (rank : 86)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	220	Shared Neighborhood Hits	10
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

NFM_HUMAN
NC score	0.011822 (rank : 87)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	1328	Shared Neighborhood Hits	35
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

GBP5_MOUSE
NC score	0.011564 (rank : 88)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CFB4, Q8CFA4	Gene names	Gbp5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (MuGBP-5).

DIAP2_HUMAN
NC score	0.011366 (rank : 89)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	342	Shared Neighborhood Hits	17
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

CFLAR_MOUSE
NC score	0.009391 (rank : 90)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

UT14C_HUMAN
NC score	0.009308 (rank : 91)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TAP6, Q5FWG3, Q92555	Gene names	UTP14C, KIAA0266
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog C.

ROCK2_HUMAN
NC score	0.009220 (rank : 92)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	2073	Shared Neighborhood Hits	36
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

PRLR_HUMAN
NC score	0.008818 (rank : 93)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PHF12_MOUSE
NC score	0.007113 (rank : 94)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	172	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

LRC8D_HUMAN
NC score	0.006528 (rank : 95)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	282	Shared Neighborhood Hits	3
SwissProt Accessions	Q7L1W4, Q6UWB2, Q9NVW3	Gene names	LRRC8D, LRRC5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

LRC8D_MOUSE
NC score	0.006498 (rank : 96)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	284	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGR2, Q3UVA9, Q8CI13	Gene names	Lrrc8d, Lrrc5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

DDX41_MOUSE
NC score	0.003282 (rank : 97)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

EP400_MOUSE
NC score	0.003161 (rank : 98)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	592	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

NEK2_MOUSE
NC score	-0.001846 (rank : 99)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	876	Shared Neighborhood Hits	4
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).