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Network neighborhood for query Sequence : FYV1_MOUSE

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FYV1_MOUSE
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FYV1_HUMAN
θ value	0 (rank : 1)	NC score	0.990390 (rank : 2)
Query Neighborhood Hits	191	Target Neighborhood Hits	217	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

TCPG_MOUSE
θ value	2.43343e-21 (rank : 3)	NC score	0.319140 (rank : 43)
Query Neighborhood Hits	191	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P80318	Gene names	Cct3, Cctg
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5).

TCPG_HUMAN
θ value	2.06002e-20 (rank : 4)	NC score	0.316167 (rank : 44)
Query Neighborhood Hits	191	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P49368, Q5SZY1, Q9BR64	Gene names	CCT3, CCTG, TRIC5
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5).

ZFY21_HUMAN
θ value	5.8054e-15 (rank : 5)	NC score	0.624763 (rank : 3)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	3.76295e-14 (rank : 6)	NC score	0.616702 (rank : 4)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	4.16044e-13 (rank : 7)	NC score	0.578879 (rank : 5)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFY16_HUMAN
θ value	3.52202e-12 (rank : 8)	NC score	0.506885 (rank : 8)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	1.02475e-11 (rank : 9)	NC score	0.511156 (rank : 7)
Query Neighborhood Hits	191	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

FYCO1_HUMAN
θ value	1.74796e-11 (rank : 10)	NC score	0.249464 (rank : 57)
Query Neighborhood Hits	191	Target Neighborhood Hits	1149	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

MTMR3_HUMAN
θ value	2.98157e-11 (rank : 11)	NC score	0.332048 (rank : 33)
Query Neighborhood Hits	191	Target Neighborhood Hits	163	Shared Neighborhood Hits	54
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_HUMAN
θ value	2.98157e-11 (rank : 12)	NC score	0.331225 (rank : 35)
Query Neighborhood Hits	191	Target Neighborhood Hits	848	Shared Neighborhood Hits	85
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ZFYV9_HUMAN
θ value	5.08577e-11 (rank : 13)	NC score	0.515200 (rank : 6)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PI52A_HUMAN
θ value	2.52405e-10 (rank : 14)	NC score	0.364321 (rank : 25)
Query Neighborhood Hits	191	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P48426, P53807, Q5VUX3	Gene names	PIP5K2A, PIP5K2
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform).

PI52A_MOUSE
θ value	3.29651e-10 (rank : 15)	NC score	0.363672 (rank : 26)
Query Neighborhood Hits	191	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	O70172	Gene names	Pip5k2a
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha).

RUFY1_MOUSE
θ value	4.30538e-10 (rank : 16)	NC score	0.335218 (rank : 32)
Query Neighborhood Hits	191	Target Neighborhood Hits	765	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

FYCO1_MOUSE
θ value	1.63604e-09 (rank : 17)	NC score	0.234774 (rank : 64)
Query Neighborhood Hits	191	Target Neighborhood Hits	1059	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ZFYV1_HUMAN
θ value	3.64472e-09 (rank : 18)	NC score	0.479542 (rank : 11)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

PI51A_MOUSE
θ value	4.76016e-09 (rank : 19)	NC score	0.335274 (rank : 31)
Query Neighborhood Hits	191	Target Neighborhood Hits	21	Shared Neighborhood Hits	12
SwissProt Accessions	P70182, Q8K0D3, Q99L80	Gene names	Pip5k1a, Pip5k1b
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (Phosphatidylinositol-4-phosphate 5- kinase type I beta) (PI4P5KIbeta) (68 kDa type I phosphatidylinositol- 4-phosphate 5-kinase).

PI52B_HUMAN
θ value	4.76016e-09 (rank : 20)	NC score	0.350556 (rank : 28)
Query Neighborhood Hits	191	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P78356, Q5U0E8, Q8TBP2	Gene names	PIP5K2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52B_MOUSE
θ value	4.76016e-09 (rank : 21)	NC score	0.350607 (rank : 27)
Query Neighborhood Hits	191	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q80XI4, Q8VHB2	Gene names	Pip5k2b
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

TCPW_MOUSE
θ value	4.76016e-09 (rank : 22)	NC score	0.250361 (rank : 56)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q61390, Q9R1U2	Gene names	Cct6b
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (Cctz- 2).

ZFYV1_MOUSE
θ value	6.21693e-09 (rank : 23)	NC score	0.476796 (rank : 12)
Query Neighborhood Hits	191	Target Neighborhood Hits	153	Shared Neighborhood Hits	56
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

RUFY2_MOUSE
θ value	8.11959e-09 (rank : 24)	NC score	0.322238 (rank : 42)
Query Neighborhood Hits	191	Target Neighborhood Hits	820	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PI51C_MOUSE
θ value	1.06045e-08 (rank : 25)	NC score	0.331238 (rank : 34)
Query Neighborhood Hits	191	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51C_HUMAN
θ value	1.38499e-08 (rank : 26)	NC score	0.325742 (rank : 39)
Query Neighborhood Hits	191	Target Neighborhood Hits	109	Shared Neighborhood Hits	16
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51B_HUMAN
θ value	2.36244e-08 (rank : 27)	NC score	0.330735 (rank : 36)
Query Neighborhood Hits	191	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

RUFY2_HUMAN
θ value	3.08544e-08 (rank : 28)	NC score	0.257913 (rank : 55)
Query Neighborhood Hits	191	Target Neighborhood Hits	1208	Shared Neighborhood Hits	88
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PI51B_MOUSE
θ value	4.0297e-08 (rank : 29)	NC score	0.329150 (rank : 38)
Query Neighborhood Hits	191	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P70181, O70335, Q8JZY6	Gene names	Pip5k1b, Pip5k1a
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PIP5KIalpha).

FGD6_MOUSE
θ value	5.26297e-08 (rank : 30)	NC score	0.365286 (rank : 24)
Query Neighborhood Hits	191	Target Neighborhood Hits	282	Shared Neighborhood Hits	57
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

WDFY3_HUMAN
θ value	8.97725e-08 (rank : 31)	NC score	0.298830 (rank : 48)
Query Neighborhood Hits	191	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	8.97725e-08 (rank : 32)	NC score	0.299631 (rank : 47)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

FGD6_HUMAN
θ value	1.17247e-07 (rank : 33)	NC score	0.370704 (rank : 21)
Query Neighborhood Hits	191	Target Neighborhood Hits	237	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PKHF2_MOUSE
θ value	1.17247e-07 (rank : 34)	NC score	0.490406 (rank : 9)
Query Neighborhood Hits	191	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

TCPW_HUMAN
θ value	1.17247e-07 (rank : 35)	NC score	0.242291 (rank : 59)
Query Neighborhood Hits	191	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q92526, Q8TC34	Gene names	CCT6B
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP-1- zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).

PI51A_HUMAN
θ value	1.99992e-07 (rank : 36)	NC score	0.324183 (rank : 40)
Query Neighborhood Hits	191	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

ANFY1_MOUSE
θ value	4.45536e-07 (rank : 37)	NC score	0.205967 (rank : 67)
Query Neighborhood Hits	191	Target Neighborhood Hits	480	Shared Neighborhood Hits	53
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

PKHF2_HUMAN
θ value	5.81887e-07 (rank : 38)	NC score	0.485062 (rank : 10)
Query Neighborhood Hits	191	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ANFY1_HUMAN
θ value	9.92553e-07 (rank : 39)	NC score	0.203773 (rank : 68)
Query Neighborhood Hits	191	Target Neighborhood Hits	480	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

HGS_HUMAN
θ value	9.92553e-07 (rank : 40)	NC score	0.397279 (rank : 17)
Query Neighborhood Hits	191	Target Neighborhood Hits	517	Shared Neighborhood Hits	67
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	1.29631e-06 (rank : 41)	NC score	0.396968 (rank : 18)
Query Neighborhood Hits	191	Target Neighborhood Hits	589	Shared Neighborhood Hits	72
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

EEA1_HUMAN
θ value	1.69304e-06 (rank : 42)	NC score	0.180545 (rank : 71)
Query Neighborhood Hits	191	Target Neighborhood Hits	1796	Shared Neighborhood Hits	100
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	1.69304e-06 (rank : 43)	NC score	0.194297 (rank : 69)
Query Neighborhood Hits	191	Target Neighborhood Hits	1637	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RBNS5_HUMAN
θ value	1.69304e-06 (rank : 44)	NC score	0.406368 (rank : 15)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	1.69304e-06 (rank : 45)	NC score	0.402392 (rank : 16)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	60
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

TCPH_HUMAN
θ value	2.21117e-06 (rank : 46)	NC score	0.239678 (rank : 60)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q99832, O14871	Gene names	CCT7, CCTH, NIP7-1
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef- interacting protein).

TCPH_MOUSE
θ value	2.21117e-06 (rank : 47)	NC score	0.238886 (rank : 62)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	P80313	Gene names	Cct7, Ccth
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta).

TCPE_MOUSE
θ value	2.88788e-06 (rank : 48)	NC score	0.239527 (rank : 61)
Query Neighborhood Hits	191	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	P80316	Gene names	Cct5, Ccte
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

TCPE_HUMAN
θ value	3.77169e-06 (rank : 49)	NC score	0.238364 (rank : 63)
Query Neighborhood Hits	191	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	P48643	Gene names	CCT5, CCTE, KIAA0098
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

FGD2_HUMAN
θ value	4.92598e-06 (rank : 50)	NC score	0.329832 (rank : 37)
Query Neighborhood Hits	191	Target Neighborhood Hits	151	Shared Neighborhood Hits	53
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
θ value	8.40245e-06 (rank : 51)	NC score	0.310111 (rank : 46)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PKHF1_MOUSE
θ value	8.40245e-06 (rank : 52)	NC score	0.469369 (rank : 13)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

FGD4_HUMAN
θ value	1.09739e-05 (rank : 53)	NC score	0.311621 (rank : 45)
Query Neighborhood Hits	191	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ZFY27_HUMAN
θ value	1.87187e-05 (rank : 54)	NC score	0.372332 (rank : 20)
Query Neighborhood Hits	191	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

RPGF4_HUMAN
θ value	2.44474e-05 (rank : 55)	NC score	0.120807 (rank : 83)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	3.19293e-05 (rank : 56)	NC score	0.120919 (rank : 82)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

ZFY27_MOUSE
θ value	4.1701e-05 (rank : 57)	NC score	0.367502 (rank : 23)
Query Neighborhood Hits	191	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

PKHF1_HUMAN
θ value	7.1131e-05 (rank : 58)	NC score	0.466375 (rank : 14)
Query Neighborhood Hits	191	Target Neighborhood Hits	76	Shared Neighborhood Hits	52
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

FGD2_MOUSE
θ value	9.29e-05 (rank : 59)	NC score	0.323346 (rank : 41)
Query Neighborhood Hits	191	Target Neighborhood Hits	163	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

GP155_HUMAN
θ value	0.000121331 (rank : 60)	NC score	0.194293 (rank : 70)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

PREX1_HUMAN
θ value	0.000121331 (rank : 61)	NC score	0.155700 (rank : 81)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

WDFY1_HUMAN
θ value	0.000461057 (rank : 62)	NC score	0.282796 (rank : 52)
Query Neighborhood Hits	191	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

FGD3_HUMAN
θ value	0.000602161 (rank : 63)	NC score	0.286175 (rank : 49)
Query Neighborhood Hits	191	Target Neighborhood Hits	249	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ZFY19_HUMAN
θ value	0.000602161 (rank : 64)	NC score	0.376077 (rank : 19)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	55
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

WDFY2_MOUSE
θ value	0.000786445 (rank : 65)	NC score	0.276434 (rank : 53)
Query Neighborhood Hits	191	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FGD5_HUMAN
θ value	0.00102713 (rank : 66)	NC score	0.343016 (rank : 30)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

WDFY2_HUMAN
θ value	0.00102713 (rank : 67)	NC score	0.273290 (rank : 54)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

TCPB_HUMAN
θ value	0.00298849 (rank : 68)	NC score	0.210265 (rank : 65)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P78371, Q6IAT3	Gene names	CCT2, 99D8.1, CCTB
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

ZFY19_MOUSE
θ value	0.00298849 (rank : 69)	NC score	0.369227 (rank : 22)
Query Neighborhood Hits	191	Target Neighborhood Hits	143	Shared Neighborhood Hits	56
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

FGD5_MOUSE
θ value	0.00390308 (rank : 70)	NC score	0.345010 (rank : 29)
Query Neighborhood Hits	191	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

TCPB_MOUSE
θ value	0.00390308 (rank : 71)	NC score	0.209346 (rank : 66)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P80314, Q9R1U0	Gene names	Cct2, Cctb
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

RGS7_HUMAN
θ value	0.00869519 (rank : 72)	NC score	0.079008 (rank : 105)
Query Neighborhood Hits	191	Target Neighborhood Hits	82	Shared Neighborhood Hits	13
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_MOUSE
θ value	0.00869519 (rank : 73)	NC score	0.079306 (rank : 104)
Query Neighborhood Hits	191	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

FGD1_HUMAN
θ value	0.0148317 (rank : 74)	NC score	0.284492 (rank : 51)
Query Neighborhood Hits	191	Target Neighborhood Hits	367	Shared Neighborhood Hits	55
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	0.0148317 (rank : 75)	NC score	0.284840 (rank : 50)
Query Neighborhood Hits	191	Target Neighborhood Hits	387	Shared Neighborhood Hits	61
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FNBP2_HUMAN
θ value	0.0330416 (rank : 76)	NC score	0.060563 (rank : 127)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	28
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CASP_HUMAN
θ value	0.0431538 (rank : 77)	NC score	0.084836 (rank : 93)
Query Neighborhood Hits	191	Target Neighborhood Hits	1131	Shared Neighborhood Hits	50
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_HUMAN
θ value	0.0431538 (rank : 78)	NC score	0.079841 (rank : 103)
Query Neighborhood Hits	191	Target Neighborhood Hits	1574	Shared Neighborhood Hits	57
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

FGD3_MOUSE
θ value	0.0431538 (rank : 79)	NC score	0.246146 (rank : 58)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	56
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

GCC2_MOUSE
θ value	0.0431538 (rank : 80)	NC score	0.064157 (rank : 121)
Query Neighborhood Hits	191	Target Neighborhood Hits	1619	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

RGS6_HUMAN
θ value	0.0431538 (rank : 81)	NC score	0.073894 (rank : 109)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS6_MOUSE
θ value	0.0431538 (rank : 82)	NC score	0.071575 (rank : 110)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

SRGP1_HUMAN
θ value	0.0563607 (rank : 83)	NC score	0.054574 (rank : 155)
Query Neighborhood Hits	191	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

DEPD5_MOUSE
θ value	0.0961366 (rank : 84)	NC score	0.085326 (rank : 91)
Query Neighborhood Hits	191	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

RPGF5_MOUSE
θ value	0.0961366 (rank : 85)	NC score	0.085251 (rank : 92)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

ZMYM3_HUMAN
θ value	0.0961366 (rank : 86)	NC score	0.064592 (rank : 119)
Query Neighborhood Hits	191	Target Neighborhood Hits	223	Shared Neighborhood Hits	11
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ZMYM3_MOUSE
θ value	0.0961366 (rank : 87)	NC score	0.064615 (rank : 118)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

CASP_MOUSE
θ value	0.125558 (rank : 88)	NC score	0.082055 (rank : 98)
Query Neighborhood Hits	191	Target Neighborhood Hits	1152	Shared Neighborhood Hits	53
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_MOUSE
θ value	0.125558 (rank : 89)	NC score	0.081854 (rank : 100)
Query Neighborhood Hits	191	Target Neighborhood Hits	1620	Shared Neighborhood Hits	65
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

DEPD5_HUMAN
θ value	0.125558 (rank : 90)	NC score	0.084397 (rank : 94)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

CTDP1_HUMAN
θ value	0.279714 (rank : 91)	NC score	0.048336 (rank : 187)
Query Neighborhood Hits	191	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

GOGA5_MOUSE
θ value	0.279714 (rank : 92)	NC score	0.061694 (rank : 124)
Query Neighborhood Hits	191	Target Neighborhood Hits	1434	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

SLK_HUMAN
θ value	0.279714 (rank : 93)	NC score	0.017068 (rank : 237)
Query Neighborhood Hits	191	Target Neighborhood Hits	1775	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SPTN5_HUMAN
θ value	0.279714 (rank : 94)	NC score	0.054863 (rank : 153)
Query Neighborhood Hits	191	Target Neighborhood Hits	674	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

DVL3_HUMAN
θ value	0.47712 (rank : 95)	NC score	0.049665 (rank : 186)
Query Neighborhood Hits	191	Target Neighborhood Hits	194	Shared Neighborhood Hits	20
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.47712 (rank : 96)	NC score	0.048069 (rank : 189)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

SLK_MOUSE
θ value	0.47712 (rank : 97)	NC score	0.015832 (rank : 238)
Query Neighborhood Hits	191	Target Neighborhood Hits	1798	Shared Neighborhood Hits	51
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

DMD_MOUSE
θ value	0.62314 (rank : 98)	NC score	0.055459 (rank : 150)
Query Neighborhood Hits	191	Target Neighborhood Hits	1111	Shared Neighborhood Hits	50
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

SH3G2_HUMAN
θ value	0.62314 (rank : 99)	NC score	0.032367 (rank : 203)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

DDX21_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.014524 (rank : 241)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

K0423_HUMAN
θ value	0.813845 (rank : 101)	NC score	0.026684 (rank : 215)
Query Neighborhood Hits	191	Target Neighborhood Hits	171	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

RAI14_MOUSE
θ value	0.813845 (rank : 102)	NC score	0.045463 (rank : 192)
Query Neighborhood Hits	191	Target Neighborhood Hits	1505	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RNF34_MOUSE
θ value	0.813845 (rank : 103)	NC score	0.116217 (rank : 86)
Query Neighborhood Hits	191	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

SH3G2_MOUSE
θ value	0.813845 (rank : 104)	NC score	0.030474 (rank : 206)
Query Neighborhood Hits	191	Target Neighborhood Hits	319	Shared Neighborhood Hits	19
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SYNE2_HUMAN
θ value	0.813845 (rank : 105)	NC score	0.054953 (rank : 152)
Query Neighborhood Hits	191	Target Neighborhood Hits	1323	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

KLDC4_MOUSE
θ value	1.06291 (rank : 106)	NC score	0.023365 (rank : 221)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q921I2, Q8CIK0	Gene names	Klhdc4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

MYH11_HUMAN
θ value	1.06291 (rank : 107)	NC score	0.042602 (rank : 197)
Query Neighborhood Hits	191	Target Neighborhood Hits	1806	Shared Neighborhood Hits	58
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NCOA6_MOUSE
θ value	1.06291 (rank : 108)	NC score	0.021438 (rank : 226)
Query Neighborhood Hits	191	Target Neighborhood Hits	1076	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

CHD4_MOUSE
θ value	1.38821 (rank : 109)	NC score	0.014351 (rank : 242)
Query Neighborhood Hits	191	Target Neighborhood Hits	408	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

KNTC2_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.052867 (rank : 164)
Query Neighborhood Hits	191	Target Neighborhood Hits	673	Shared Neighborhood Hits	39
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

LRC50_MOUSE
θ value	1.38821 (rank : 111)	NC score	0.026936 (rank : 214)
Query Neighborhood Hits	191	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

SPTB2_HUMAN
θ value	1.38821 (rank : 112)	NC score	0.045008 (rank : 194)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	1.38821 (rank : 113)	NC score	0.044860 (rank : 195)
Query Neighborhood Hits	191	Target Neighborhood Hits	770	Shared Neighborhood Hits	43
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

TGON2_HUMAN
θ value	1.38821 (rank : 114)	NC score	0.033977 (rank : 200)
Query Neighborhood Hits	191	Target Neighborhood Hits	1037	Shared Neighborhood Hits	26
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

BRD3_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.017697 (rank : 235)
Query Neighborhood Hits	191	Target Neighborhood Hits	402	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

GOGA5_HUMAN
θ value	1.81305 (rank : 116)	NC score	0.059674 (rank : 132)
Query Neighborhood Hits	191	Target Neighborhood Hits	1168	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

K1HB_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.022967 (rank : 224)
Query Neighborhood Hits	191	Target Neighborhood Hits	470	Shared Neighborhood Hits	33
SwissProt Accessions	Q14525, O76010	Gene names	KRTHA3B, HHA3-II, HKA3B
Domain Architecture
Description	Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II).

KCNK5_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.013657 (rank : 246)
Query Neighborhood Hits	191	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

RRMJ3_HUMAN
θ value	1.81305 (rank : 119)	NC score	0.029685 (rank : 209)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6	Gene names	FTSJ3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

ZNF70_HUMAN
θ value	1.81305 (rank : 120)	NC score	-0.000553 (rank : 270)
Query Neighborhood Hits	191	Target Neighborhood Hits	760	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

CADH3_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.001792 (rank : 266)
Query Neighborhood Hits	191	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	P22223	Gene names	CDH3, CDHP
Domain Architecture
Description	Cadherin-3 precursor (Placental-cadherin) (P-cadherin).

E2AK4_HUMAN
θ value	2.36792 (rank : 122)	NC score	0.001712 (rank : 267)
Query Neighborhood Hits	191	Target Neighborhood Hits	1012	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

EP400_MOUSE
θ value	2.36792 (rank : 123)	NC score	0.013038 (rank : 249)
Query Neighborhood Hits	191	Target Neighborhood Hits	592	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

GNAS3_MOUSE
θ value	2.36792 (rank : 124)	NC score	0.032292 (rank : 204)
Query Neighborhood Hits	191	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0F1, Q9QXW5, Q9Z0H2	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Neuroendocrine secretory protein 55 (NESP55) [Contains: LHAL tetrapeptide; GPIPIRRH peptide].

MY18A_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.047954 (rank : 190)
Query Neighborhood Hits	191	Target Neighborhood Hits	1929	Shared Neighborhood Hits	75
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH10_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.044357 (rank : 196)
Query Neighborhood Hits	191	Target Neighborhood Hits	1612	Shared Neighborhood Hits	61
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PRD14_HUMAN
θ value	2.36792 (rank : 127)	NC score	-0.002465 (rank : 273)
Query Neighborhood Hits	191	Target Neighborhood Hits	757	Shared Neighborhood Hits	9
SwissProt Accessions	Q9GZV8, Q86UX9	Gene names	PRDM14
Domain Architecture
Description	PR domain zinc finger protein 14 (PR domain-containing protein 14).

RNF34_HUMAN
θ value	2.36792 (rank : 128)	NC score	0.105428 (rank : 88)
Query Neighborhood Hits	191	Target Neighborhood Hits	153	Shared Neighborhood Hits	31
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

SL9A3_HUMAN
θ value	2.36792 (rank : 129)	NC score	0.018814 (rank : 230)
Query Neighborhood Hits	191	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P48764	Gene names	SLC9A3, NHE3
Domain Architecture
Description	Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3).

SPTA1_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.050169 (rank : 184)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VCAM1_MOUSE
θ value	2.36792 (rank : 131)	NC score	0.010064 (rank : 257)
Query Neighborhood Hits	191	Target Neighborhood Hits	320	Shared Neighborhood Hits	3
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

ZN507_HUMAN
θ value	2.36792 (rank : 132)	NC score	0.002858 (rank : 264)
Query Neighborhood Hits	191	Target Neighborhood Hits	739	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

ARP5_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.029825 (rank : 208)
Query Neighborhood Hits	191	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	Q80US4, Q8BL26	Gene names	Actr5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5.

K1949_MOUSE
θ value	3.0926 (rank : 134)	NC score	0.018622 (rank : 232)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

MBB1A_MOUSE
θ value	3.0926 (rank : 135)	NC score	0.023472 (rank : 220)
Query Neighborhood Hits	191	Target Neighborhood Hits	233	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

MLL2_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.029870 (rank : 207)
Query Neighborhood Hits	191	Target Neighborhood Hits	1788	Shared Neighborhood Hits	55
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MYH10_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.045021 (rank : 193)
Query Neighborhood Hits	191	Target Neighborhood Hits	1620	Shared Neighborhood Hits	60
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NEK1_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.001433 (rank : 268)
Query Neighborhood Hits	191	Target Neighborhood Hits	1311	Shared Neighborhood Hits	29
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

UB7I4_MOUSE
θ value	3.0926 (rank : 139)	NC score	0.027515 (rank : 213)
Query Neighborhood Hits	191	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

ACO12_HUMAN
θ value	4.03905 (rank : 140)	NC score	0.012269 (rank : 250)
Query Neighborhood Hits	191	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WYK0	Gene names	ACOT12, CACH, CACH1, STARD12
Domain Architecture
Description	Acyl-coenzyme A thioesterase 12 (EC 3.1.2.1) (Acyl-CoA thioesterase 12) (Acyl-CoA thioester hydrolase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 12) (StARD12).

ARP5_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.026044 (rank : 216)
Query Neighborhood Hits	191	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H9F9, Q86WF7, Q8IUY5, Q8N724, Q9BRN0, Q9BVB7	Gene names	ACTR5, ARP5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16).

CP135_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.053127 (rank : 161)
Query Neighborhood Hits	191	Target Neighborhood Hits	1290	Shared Neighborhood Hits	48
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

K1196_HUMAN
θ value	4.03905 (rank : 143)	NC score	0.007558 (rank : 261)
Query Neighborhood Hits	191	Target Neighborhood Hits	618	Shared Neighborhood Hits	9
SwissProt Accessions	Q96KM6, Q9ULM4	Gene names	KIAA1196
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1196.

MYH11_MOUSE
θ value	4.03905 (rank : 144)	NC score	0.041997 (rank : 198)
Query Neighborhood Hits	191	Target Neighborhood Hits	1777	Shared Neighborhood Hits	62
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYRIP_HUMAN
θ value	4.03905 (rank : 145)	NC score	0.033018 (rank : 202)
Query Neighborhood Hits	191	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NOC2L_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.025948 (rank : 217)
Query Neighborhood Hits	191	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

PELP1_MOUSE
θ value	4.03905 (rank : 147)	NC score	0.021175 (rank : 227)
Query Neighborhood Hits	191	Target Neighborhood Hits	709	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

SAP_HUMAN
θ value	4.03905 (rank : 148)	NC score	0.025583 (rank : 218)
Query Neighborhood Hits	191	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

SRGP2_HUMAN
θ value	4.03905 (rank : 149)	NC score	0.033899 (rank : 201)
Query Neighborhood Hits	191	Target Neighborhood Hits	331	Shared Neighborhood Hits	20
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	4.03905 (rank : 150)	NC score	0.034322 (rank : 199)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	20
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRRM2_MOUSE
θ value	4.03905 (rank : 151)	NC score	0.012228 (rank : 251)
Query Neighborhood Hits	191	Target Neighborhood Hits	1470	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

THAP4_HUMAN
θ value	4.03905 (rank : 152)	NC score	0.014294 (rank : 243)
Query Neighborhood Hits	191	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY91, Q53NU7, Q6GRN0, Q6IPJ3, Q9NW26, Q9Y325	Gene names	THAP4
Domain Architecture
Description	THAP domain-containing protein 4.

TISD_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.013317 (rank : 247)
Query Neighborhood Hits	191	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

UB7I4_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.023593 (rank : 219)
Query Neighborhood Hits	191	Target Neighborhood Hits	54	Shared Neighborhood Hits	6
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

ZO2_MOUSE
θ value	4.03905 (rank : 155)	NC score	0.011921 (rank : 252)
Query Neighborhood Hits	191	Target Neighborhood Hits	296	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

C8AP2_HUMAN
θ value	5.27518 (rank : 156)	NC score	0.015820 (rank : 239)
Query Neighborhood Hits	191	Target Neighborhood Hits	548	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CAC1I_HUMAN
θ value	5.27518 (rank : 157)	NC score	0.009119 (rank : 259)
Query Neighborhood Hits	191	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CIZ1_HUMAN
θ value	5.27518 (rank : 158)	NC score	0.022547 (rank : 225)
Query Neighborhood Hits	191	Target Neighborhood Hits	359	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

HAP1_MOUSE
θ value	5.27518 (rank : 159)	NC score	0.032121 (rank : 205)
Query Neighborhood Hits	191	Target Neighborhood Hits	388	Shared Neighborhood Hits	32
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

INVO_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.061203 (rank : 125)
Query Neighborhood Hits	191	Target Neighborhood Hits	636	Shared Neighborhood Hits	42
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

MY18A_MOUSE
θ value	5.27518 (rank : 161)	NC score	0.046744 (rank : 191)
Query Neighborhood Hits	191	Target Neighborhood Hits	1989	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RNF31_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.023224 (rank : 223)
Query Neighborhood Hits	191	Target Neighborhood Hits	110	Shared Neighborhood Hits	12
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

TRI32_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.018964 (rank : 229)
Query Neighborhood Hits	191	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.018721 (rank : 231)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

UN84B_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.019568 (rank : 228)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH99, O75156, Q6B4H1, Q7Z3E3	Gene names	UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2
Domain Architecture	No domain graphic available
Description	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP).

YTDC1_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.017385 (rank : 236)
Query Neighborhood Hits	191	Target Neighborhood Hits	458	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZN323_HUMAN
θ value	5.27518 (rank : 167)	NC score	-0.000378 (rank : 269)
Query Neighborhood Hits	191	Target Neighborhood Hits	802	Shared Neighborhood Hits	21
SwissProt Accessions	Q96LW9, Q8WWS5	Gene names	ZNF323
Domain Architecture
Description	Zinc finger protein 323.

ZNF8_HUMAN
θ value	5.27518 (rank : 168)	NC score	-0.003524 (rank : 274)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P17098, Q6PI99	Gene names	ZNF8
Domain Architecture	No domain graphic available
Description	Zinc finger protein 8 (Zinc finger protein HF.18).

AIRE_HUMAN
θ value	6.88961 (rank : 169)	NC score	0.009722 (rank : 258)
Query Neighborhood Hits	191	Target Neighborhood Hits	144	Shared Neighborhood Hits	6
SwissProt Accessions	O43918, O43922, O43932, O75745	Gene names	AIRE, APECED
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein).

ATX2L_HUMAN
θ value	6.88961 (rank : 170)	NC score	0.018439 (rank : 233)
Query Neighborhood Hits	191	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

DDX10_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.005589 (rank : 263)
Query Neighborhood Hits	191	Target Neighborhood Hits	233	Shared Neighborhood Hits	10
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DMD_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.048112 (rank : 188)
Query Neighborhood Hits	191	Target Neighborhood Hits	1135	Shared Neighborhood Hits	48
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DYHC_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.029162 (rank : 210)
Query Neighborhood Hits	191	Target Neighborhood Hits	733	Shared Neighborhood Hits	40
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DZIP1_HUMAN
θ value	6.88961 (rank : 174)	NC score	0.023258 (rank : 222)
Query Neighborhood Hits	191	Target Neighborhood Hits	675	Shared Neighborhood Hits	31
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

GMIP_MOUSE
θ value	6.88961 (rank : 175)	NC score	0.017913 (rank : 234)
Query Neighborhood Hits	191	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

IQEC3_MOUSE
θ value	6.88961 (rank : 176)	NC score	0.013999 (rank : 244)
Query Neighborhood Hits	191	Target Neighborhood Hits	274	Shared Neighborhood Hits	18
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NFH_MOUSE
θ value	6.88961 (rank : 177)	NC score	0.013955 (rank : 245)
Query Neighborhood Hits	191	Target Neighborhood Hits	2247	Shared Neighborhood Hits	60
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RIMS1_HUMAN
θ value	6.88961 (rank : 178)	NC score	0.007752 (rank : 260)
Query Neighborhood Hits	191	Target Neighborhood Hits	437	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

STK4_MOUSE
θ value	6.88961 (rank : 179)	NC score	-0.002216 (rank : 271)
Query Neighborhood Hits	191	Target Neighborhood Hits	873	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

WDR34_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.014977 (rank : 240)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q96EX3, Q5VXV4, Q9BV46	Gene names	WDR34
Domain Architecture
Description	WD repeat protein 34.

CITE4_MOUSE
θ value	8.99809 (rank : 181)	NC score	0.011051 (rank : 256)
Query Neighborhood Hits	191	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUL8, Q66JX0, Q8R176, Q9CZV4	Gene names	Cited4, Mrg2
Domain Architecture	No domain graphic available
Description	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG- 2).

CUTL2_MOUSE
θ value	8.99809 (rank : 182)	NC score	0.053191 (rank : 160)
Query Neighborhood Hits	191	Target Neighborhood Hits	771	Shared Neighborhood Hits	38
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

DVL2_HUMAN
θ value	8.99809 (rank : 183)	NC score	0.027550 (rank : 212)
Query Neighborhood Hits	191	Target Neighborhood Hits	223	Shared Neighborhood Hits	17
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	8.99809 (rank : 184)	NC score	0.028254 (rank : 211)
Query Neighborhood Hits	191	Target Neighborhood Hits	233	Shared Neighborhood Hits	18
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

IMB1_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.011153 (rank : 255)
Query Neighborhood Hits	191	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

IMB1_MOUSE
θ value	8.99809 (rank : 186)	NC score	0.011205 (rank : 254)
Query Neighborhood Hits	191	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

NSD1_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.011624 (rank : 253)
Query Neighborhood Hits	191	Target Neighborhood Hits	472	Shared Neighborhood Hits	19
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PTN23_HUMAN
θ value	8.99809 (rank : 188)	NC score	0.013075 (rank : 248)
Query Neighborhood Hits	191	Target Neighborhood Hits	646	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

SON_MOUSE
θ value	8.99809 (rank : 189)	NC score	0.006618 (rank : 262)
Query Neighborhood Hits	191	Target Neighborhood Hits	957	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

STK4_HUMAN
θ value	8.99809 (rank : 190)	NC score	-0.002421 (rank : 272)
Query Neighborhood Hits	191	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

TAOK2_HUMAN
θ value	8.99809 (rank : 191)	NC score	0.002477 (rank : 265)
Query Neighborhood Hits	191	Target Neighborhood Hits	1172	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

ABR_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.058509 (rank : 138)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.055505 (rank : 149)
Query Neighborhood Hits	191	Target Neighborhood Hits	120	Shared Neighborhood Hits	15
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG4_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.059293 (rank : 134)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.057631 (rank : 141)
Query Neighborhood Hits	191	Target Neighborhood Hits	185	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.066813 (rank : 116)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG9_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.055696 (rank : 148)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.055200 (rank : 151)
Query Neighborhood Hits	191	Target Neighborhood Hits	234	Shared Neighborhood Hits	20
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.064445 (rank : 120)
Query Neighborhood Hits	191	Target Neighborhood Hits	187	Shared Neighborhood Hits	17
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.065295 (rank : 117)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGF_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.060043 (rank : 130)
Query Neighborhood Hits	191	Target Neighborhood Hits	214	Shared Neighborhood Hits	17
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.058454 (rank : 139)
Query Neighborhood Hits	191	Target Neighborhood Hits	129	Shared Neighborhood Hits	15
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.054428 (rank : 156)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	15
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BBS10_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.070201 (rank : 111)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TAM1, Q96CW2, Q9H5D2	Gene names	BBS10, C12orf58
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein.

BBS10_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.058614 (rank : 136)
Query Neighborhood Hits	191	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBI2	Gene names	Bbs10
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein homolog.

BCR_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.059977 (rank : 131)
Query Neighborhood Hits	191	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CARD9_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.051307 (rank : 170)
Query Neighborhood Hits	191	Target Neighborhood Hits	602	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CCDC6_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.057026 (rank : 144)
Query Neighborhood Hits	191	Target Neighborhood Hits	723	Shared Neighborhood Hits	43
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCHCR_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.053519 (rank : 159)
Query Neighborhood Hits	191	Target Neighborhood Hits	932	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CE290_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.053065 (rank : 163)
Query Neighborhood Hits	191	Target Neighborhood Hits	1553	Shared Neighborhood Hits	51
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CEP63_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.052839 (rank : 165)
Query Neighborhood Hits	191	Target Neighborhood Hits	1005	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF182_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.050512 (rank : 181)
Query Neighborhood Hits	191	Target Neighborhood Hits	551	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CH60_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.104496 (rank : 89)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P10809	Gene names	HSPD1, HSP60
Domain Architecture
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60).

CH60_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.112329 (rank : 87)
Query Neighborhood Hits	191	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	P63038, P19226, P19227, P97602	Gene names	Hspd1, Hsp60
Domain Architecture	No domain graphic available
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65).

CJ064_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.068853 (rank : 113)
Query Neighborhood Hits	191	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CNTRB_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.050600 (rank : 180)
Query Neighborhood Hits	191	Target Neighborhood Hits	1029	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CRF_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.056875 (rank : 146)
Query Neighborhood Hits	191	Target Neighborhood Hits	9	Shared Neighborhood Hits	1
SwissProt Accessions	Q8CIT0	Gene names	Crh
Domain Architecture	No domain graphic available
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

CYTSA_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.050628 (rank : 178)
Query Neighborhood Hits	191	Target Neighborhood Hits	1104	Shared Neighborhood Hits	48
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

ECT2_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.075708 (rank : 108)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.077492 (rank : 107)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP1_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.080880 (rank : 101)
Query Neighborhood Hits	191	Target Neighborhood Hits	241	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.083468 (rank : 96)
Query Neighborhood Hits	191	Target Neighborhood Hits	240	Shared Neighborhood Hits	23
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.081941 (rank : 99)
Query Neighborhood Hits	191	Target Neighborhood Hits	209	Shared Neighborhood Hits	18
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GCC2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.051023 (rank : 174)
Query Neighborhood Hits	191	Target Neighborhood Hits	1558	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GNRP_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.069243 (rank : 112)
Query Neighborhood Hits	191	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.067365 (rank : 115)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GOGA1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.053780 (rank : 158)
Query Neighborhood Hits	191	Target Neighborhood Hits	1222	Shared Neighborhood Hits	54
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.051856 (rank : 167)
Query Neighborhood Hits	191	Target Neighborhood Hits	994	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA2_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.054760 (rank : 154)
Query Neighborhood Hits	191	Target Neighborhood Hits	856	Shared Neighborhood Hits	47
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA2_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.053066 (rank : 162)
Query Neighborhood Hits	191	Target Neighborhood Hits	944	Shared Neighborhood Hits	40
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GOGA3_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.053943 (rank : 157)
Query Neighborhood Hits	191	Target Neighborhood Hits	1317	Shared Neighborhood Hits	52
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.056093 (rank : 147)
Query Neighborhood Hits	191	Target Neighborhood Hits	1437	Shared Neighborhood Hits	58
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

HAPIP_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.080408 (rank : 102)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.060195 (rank : 129)
Query Neighborhood Hits	191	Target Neighborhood Hits	1757	Shared Neighborhood Hits	66
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.059457 (rank : 133)
Query Neighborhood Hits	191	Target Neighborhood Hits	1669	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.058309 (rank : 140)
Query Neighborhood Hits	191	Target Neighborhood Hits	1173	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.058689 (rank : 135)
Query Neighborhood Hits	191	Target Neighborhood Hits	1371	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

KTN1_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.051359 (rank : 169)
Query Neighborhood Hits	191	Target Neighborhood Hits	1324	Shared Neighborhood Hits	47
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MCF2L_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.063284 (rank : 122)
Query Neighborhood Hits	191	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.058532 (rank : 137)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	21
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MD1L1_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.052467 (rank : 166)
Query Neighborhood Hits	191	Target Neighborhood Hits	1001	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MKKS_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.078136 (rank : 106)
Query Neighborhood Hits	191	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPJ1	Gene names	MKKS
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Bardet- Biedl syndrome 6 protein).

MKKS_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.096040 (rank : 90)
Query Neighborhood Hits	191	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JI70	Gene names	Mkks
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.

NGEF_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.061094 (rank : 126)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.060550 (rank : 128)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NUMA1_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.050317 (rank : 182)
Query Neighborhood Hits	191	Target Neighborhood Hits	1523	Shared Neighborhood Hits	58
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PKHG1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.067734 (rank : 114)
Query Neighborhood Hits	191	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.057290 (rank : 142)
Query Neighborhood Hits	191	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RABE1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.050795 (rank : 177)
Query Neighborhood Hits	191	Target Neighborhood Hits	1104	Shared Neighborhood Hits	47
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.051681 (rank : 168)
Query Neighborhood Hits	191	Target Neighborhood Hits	545	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RABE2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.056970 (rank : 145)
Query Neighborhood Hits	191	Target Neighborhood Hits	598	Shared Neighborhood Hits	40
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RB6I2_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.051012 (rank : 175)
Query Neighborhood Hits	191	Target Neighborhood Hits	1433	Shared Neighborhood Hits	49
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBP24_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.051038 (rank : 173)
Query Neighborhood Hits	191	Target Neighborhood Hits	1559	Shared Neighborhood Hits	56
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RFFL_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.082369 (rank : 97)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.084022 (rank : 95)
Query Neighborhood Hits	191	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RPGF3_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.050931 (rank : 176)
Query Neighborhood Hits	191	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.051243 (rank : 171)
Query Neighborhood Hits	191	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF5_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.050291 (rank : 183)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RUFY3_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.117273 (rank : 85)
Query Neighborhood Hits	191	Target Neighborhood Hits	594	Shared Neighborhood Hits	31
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.118202 (rank : 84)
Query Neighborhood Hits	191	Target Neighborhood Hits	579	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SPAG5_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.050616 (rank : 179)
Query Neighborhood Hits	191	Target Neighborhood Hits	612	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SWP70_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.062138 (rank : 123)
Query Neighborhood Hits	191	Target Neighborhood Hits	973	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.057259 (rank : 143)
Query Neighborhood Hits	191	Target Neighborhood Hits	1097	Shared Neighborhood Hits	61
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYNE1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.050066 (rank : 185)
Query Neighborhood Hits	191	Target Neighborhood Hits	1484	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TCPA1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.158269 (rank : 77)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P11984	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha A (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1A) (TCP-1-A).

TCPA2_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.158258 (rank : 78)
Query Neighborhood Hits	191	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P11983	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha B (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1B) (TCP-1-B).

TCPA_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.159252 (rank : 76)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P17987, Q15556, Q5TCM3	Gene names	CCT1, CCTA, TCP1
Domain Architecture
Description	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha).

TCPD_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.168079 (rank : 74)
Query Neighborhood Hits	191	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	P50991, O14870, Q96C51	Gene names	CCT4, CCTD, SRB
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding).

TCPD_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.166432 (rank : 75)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	P80315	Gene names	Cct4, Cctd
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (A45).

TCPQ_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.156715 (rank : 79)
Query Neighborhood Hits	191	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P50990	Gene names	CCT8, CCTQ, KIAA0002
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (NY-REN-15 antigen).

TCPQ_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.156328 (rank : 80)
Query Neighborhood Hits	191	Target Neighborhood Hits	33	Shared Neighborhood Hits	10
SwissProt Accessions	P42932	Gene names	Cct8, Cctq
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta).

TCPZ_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.173790 (rank : 73)
Query Neighborhood Hits	191	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	P40227, Q75LP4, Q96S46	Gene names	CCT6A, CCT6, CCTZ
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Tcp20) (HTR3) (Acute morphine dependence-related protein 2).

TCPZ_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.174127 (rank : 72)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	10
SwissProt Accessions	P80317	Gene names	Cct6a, Cct6, Cctz, Cctz1
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1).

TSC1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.051099 (rank : 172)
Query Neighborhood Hits	191	Target Neighborhood Hits	765	Shared Neighborhood Hits	37
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

Hits sorted by NC score

FYV1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.990390 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	191	Target Neighborhood Hits	217	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ZFY21_HUMAN
NC score	0.624763 (rank : 3)	θ value	5.8054e-15 (rank : 5)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
NC score	0.616702 (rank : 4)	θ value	3.76295e-14 (rank : 6)
Query Neighborhood Hits	191	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
NC score	0.578879 (rank : 5)	θ value	4.16044e-13 (rank : 7)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.515200 (rank : 6)	θ value	5.08577e-11 (rank : 13)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
NC score	0.511156 (rank : 7)	θ value	1.02475e-11 (rank : 9)
Query Neighborhood Hits	191	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.506885 (rank : 8)	θ value	3.52202e-12 (rank : 8)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

PKHF2_MOUSE
NC score	0.490406 (rank : 9)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	191	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.485062 (rank : 10)	θ value	5.81887e-07 (rank : 38)
Query Neighborhood Hits	191	Target Neighborhood Hits	75	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ZFYV1_HUMAN
NC score	0.479542 (rank : 11)	θ value	3.64472e-09 (rank : 18)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.476796 (rank : 12)	θ value	6.21693e-09 (rank : 23)
Query Neighborhood Hits	191	Target Neighborhood Hits	153	Shared Neighborhood Hits	56
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PKHF1_MOUSE
NC score	0.469369 (rank : 13)	θ value	8.40245e-06 (rank : 52)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
NC score	0.466375 (rank : 14)	θ value	7.1131e-05 (rank : 58)
Query Neighborhood Hits	191	Target Neighborhood Hits	76	Shared Neighborhood Hits	52
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RBNS5_HUMAN
NC score	0.406368 (rank : 15)	θ value	1.69304e-06 (rank : 44)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.402392 (rank : 16)	θ value	1.69304e-06 (rank : 45)
Query Neighborhood Hits	191	Target Neighborhood Hits	266	Shared Neighborhood Hits	60
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

HGS_HUMAN
NC score	0.397279 (rank : 17)	θ value	9.92553e-07 (rank : 40)
Query Neighborhood Hits	191	Target Neighborhood Hits	517	Shared Neighborhood Hits	67
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.396968 (rank : 18)	θ value	1.29631e-06 (rank : 41)
Query Neighborhood Hits	191	Target Neighborhood Hits	589	Shared Neighborhood Hits	72
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ZFY19_HUMAN
NC score	0.376077 (rank : 19)	θ value	0.000602161 (rank : 64)
Query Neighborhood Hits	191	Target Neighborhood Hits	206	Shared Neighborhood Hits	55
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY27_HUMAN
NC score	0.372332 (rank : 20)	θ value	1.87187e-05 (rank : 54)
Query Neighborhood Hits	191	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FGD6_HUMAN
NC score	0.370704 (rank : 21)	θ value	1.17247e-07 (rank : 33)
Query Neighborhood Hits	191	Target Neighborhood Hits	237	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ZFY19_MOUSE
NC score	0.369227 (rank : 22)	θ value	0.00298849 (rank : 69)
Query Neighborhood Hits	191	Target Neighborhood Hits	143	Shared Neighborhood Hits	56
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY27_MOUSE
NC score	0.367502 (rank : 23)	θ value	4.1701e-05 (rank : 57)
Query Neighborhood Hits	191	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FGD6_MOUSE
NC score	0.365286 (rank : 24)	θ value	5.26297e-08 (rank : 30)
Query Neighborhood Hits	191	Target Neighborhood Hits	282	Shared Neighborhood Hits	57
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

PI52A_HUMAN
NC score	0.364321 (rank : 25)	θ value	2.52405e-10 (rank : 14)
Query Neighborhood Hits	191	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	P48426, P53807, Q5VUX3	Gene names	PIP5K2A, PIP5K2
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha) (PtdIns(4)P-5-kinase B isoform) (PIP5KIII) (PtdIns(4)P-5-kinase C isoform).

PI52A_MOUSE
NC score	0.363672 (rank : 26)	θ value	3.29651e-10 (rank : 15)
Query Neighborhood Hits	191	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	O70172	Gene names	Pip5k2a
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II alpha) (1- phosphatidylinositol-4-phosphate 5-kinase 2-alpha) (PtdIns(4)P-5- kinase isoform 2-alpha) (PIP5KII-alpha) (Diphosphoinositide kinase 2- alpha).

PI52B_MOUSE
NC score	0.350607 (rank : 27)	θ value	4.76016e-09 (rank : 21)
Query Neighborhood Hits	191	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q80XI4, Q8VHB2	Gene names	Pip5k2b
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

PI52B_HUMAN
NC score	0.350556 (rank : 28)	θ value	4.76016e-09 (rank : 20)
Query Neighborhood Hits	191	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P78356, Q5U0E8, Q8TBP2	Gene names	PIP5K2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 5-kinase type-2 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type II beta) (1- phosphatidylinositol-4-phosphate 5-kinase 2-beta) (PtdIns(4)P-5-kinase isoform 2-beta) (PIP5KII-beta) (Diphosphoinositide kinase 2-beta).

FGD5_MOUSE
NC score	0.345010 (rank : 29)	θ value	0.00390308 (rank : 70)
Query Neighborhood Hits	191	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
NC score	0.343016 (rank : 30)	θ value	0.00102713 (rank : 66)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PI51A_MOUSE
NC score	0.335274 (rank : 31)	θ value	4.76016e-09 (rank : 19)
Query Neighborhood Hits	191	Target Neighborhood Hits	21	Shared Neighborhood Hits	12
SwissProt Accessions	P70182, Q8K0D3, Q99L80	Gene names	Pip5k1a, Pip5k1b
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (Phosphatidylinositol-4-phosphate 5- kinase type I beta) (PI4P5KIbeta) (68 kDa type I phosphatidylinositol- 4-phosphate 5-kinase).

RUFY1_MOUSE
NC score	0.335218 (rank : 32)	θ value	4.30538e-10 (rank : 16)
Query Neighborhood Hits	191	Target Neighborhood Hits	765	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

MTMR3_HUMAN
NC score	0.332048 (rank : 33)	θ value	2.98157e-11 (rank : 11)
Query Neighborhood Hits	191	Target Neighborhood Hits	163	Shared Neighborhood Hits	54
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PI51C_MOUSE
NC score	0.331238 (rank : 34)	θ value	1.06045e-08 (rank : 25)
Query Neighborhood Hits	191	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

RUFY1_HUMAN
NC score	0.331225 (rank : 35)	θ value	2.98157e-11 (rank : 12)
Query Neighborhood Hits	191	Target Neighborhood Hits	848	Shared Neighborhood Hits	85
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

PI51B_HUMAN
NC score	0.330735 (rank : 36)	θ value	2.36244e-08 (rank : 27)
Query Neighborhood Hits	191	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

FGD2_HUMAN
NC score	0.329832 (rank : 37)	θ value	4.92598e-06 (rank : 50)
Query Neighborhood Hits	191	Target Neighborhood Hits	151	Shared Neighborhood Hits	53
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PI51B_MOUSE
NC score	0.329150 (rank : 38)	θ value	4.0297e-08 (rank : 29)
Query Neighborhood Hits	191	Target Neighborhood Hits	15	Shared Neighborhood Hits	12
SwissProt Accessions	P70181, O70335, Q8JZY6	Gene names	Pip5k1b, Pip5k1a
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PIP5KIalpha).

PI51C_HUMAN
NC score	0.325742 (rank : 39)	θ value	1.38499e-08 (rank : 26)
Query Neighborhood Hits	191	Target Neighborhood Hits	109	Shared Neighborhood Hits	16
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PI51A_HUMAN
NC score	0.324183 (rank : 40)	θ value	1.99992e-07 (rank : 36)
Query Neighborhood Hits	191	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

FGD2_MOUSE
NC score	0.323346 (rank : 41)	θ value	9.29e-05 (rank : 59)
Query Neighborhood Hits	191	Target Neighborhood Hits	163	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

RUFY2_MOUSE
NC score	0.322238 (rank : 42)	θ value	8.11959e-09 (rank : 24)
Query Neighborhood Hits	191	Target Neighborhood Hits	820	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TCPG_MOUSE
NC score	0.319140 (rank : 43)	θ value	2.43343e-21 (rank : 3)
Query Neighborhood Hits	191	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P80318	Gene names	Cct3, Cctg
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (Matricin) (mTRiC-P5).

TCPG_HUMAN
NC score	0.316167 (rank : 44)	θ value	2.06002e-20 (rank : 4)
Query Neighborhood Hits	191	Target Neighborhood Hits	35	Shared Neighborhood Hits	12
SwissProt Accessions	P49368, Q5SZY1, Q9BR64	Gene names	CCT3, CCTG, TRIC5
Domain Architecture
Description	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5).

FGD4_HUMAN
NC score	0.311621 (rank : 45)	θ value	1.09739e-05 (rank : 53)
Query Neighborhood Hits	191	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.310111 (rank : 46)	θ value	8.40245e-06 (rank : 51)
Query Neighborhood Hits	191	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

WDFY3_MOUSE
NC score	0.299631 (rank : 47)	θ value	8.97725e-08 (rank : 32)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.298830 (rank : 48)	θ value	8.97725e-08 (rank : 31)
Query Neighborhood Hits	191	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

FGD3_HUMAN
NC score	0.286175 (rank : 49)	θ value	0.000602161 (rank : 63)
Query Neighborhood Hits	191	Target Neighborhood Hits	249	Shared Neighborhood Hits	57
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD1_MOUSE
NC score	0.284840 (rank : 50)	θ value	0.0148317 (rank : 75)
Query Neighborhood Hits	191	Target Neighborhood Hits	387	Shared Neighborhood Hits	61
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.284492 (rank : 51)	θ value	0.0148317 (rank : 74)
Query Neighborhood Hits	191	Target Neighborhood Hits	367	Shared Neighborhood Hits	55
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

WDFY1_HUMAN
NC score	0.282796 (rank : 52)	θ value	0.000461057 (rank : 62)
Query Neighborhood Hits	191	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_MOUSE
NC score	0.276434 (rank : 53)	θ value	0.000786445 (rank : 65)
Query Neighborhood Hits	191	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.273290 (rank : 54)	θ value	0.00102713 (rank : 67)
Query Neighborhood Hits	191	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_HUMAN
NC score	0.257913 (rank : 55)	θ value	3.08544e-08 (rank : 28)
Query Neighborhood Hits	191	Target Neighborhood Hits	1208	Shared Neighborhood Hits	88
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TCPW_MOUSE
NC score	0.250361 (rank : 56)	θ value	4.76016e-09 (rank : 22)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q61390, Q9R1U2	Gene names	Cct6b
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (Cctz- 2).

FYCO1_HUMAN
NC score	0.249464 (rank : 57)	θ value	1.74796e-11 (rank : 10)
Query Neighborhood Hits	191	Target Neighborhood Hits	1149	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FGD3_MOUSE
NC score	0.246146 (rank : 58)	θ value	0.0431538 (rank : 79)
Query Neighborhood Hits	191	Target Neighborhood Hits	257	Shared Neighborhood Hits	56
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TCPW_HUMAN
NC score	0.242291 (rank : 59)	θ value	1.17247e-07 (rank : 35)
Query Neighborhood Hits	191	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q92526, Q8TC34	Gene names	CCT6B
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP-1- zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).

TCPH_HUMAN
NC score	0.239678 (rank : 60)	θ value	2.21117e-06 (rank : 46)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q99832, O14871	Gene names	CCT7, CCTH, NIP7-1
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef- interacting protein).

TCPE_MOUSE
NC score	0.239527 (rank : 61)	θ value	2.88788e-06 (rank : 48)
Query Neighborhood Hits	191	Target Neighborhood Hits	37	Shared Neighborhood Hits	12
SwissProt Accessions	P80316	Gene names	Cct5, Ccte
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

TCPH_MOUSE
NC score	0.238886 (rank : 62)	θ value	2.21117e-06 (rank : 47)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	P80313	Gene names	Cct7, Ccth
Domain Architecture
Description	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta).

TCPE_HUMAN
NC score	0.238364 (rank : 63)	θ value	3.77169e-06 (rank : 49)
Query Neighborhood Hits	191	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	P48643	Gene names	CCT5, CCTE, KIAA0098
Domain Architecture
Description	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon).

FYCO1_MOUSE
NC score	0.234774 (rank : 64)	θ value	1.63604e-09 (rank : 17)
Query Neighborhood Hits	191	Target Neighborhood Hits	1059	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

TCPB_HUMAN
NC score	0.210265 (rank : 65)	θ value	0.00298849 (rank : 68)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P78371, Q6IAT3	Gene names	CCT2, 99D8.1, CCTB
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

TCPB_MOUSE
NC score	0.209346 (rank : 66)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	P80314, Q9R1U0	Gene names	Cct2, Cctb
Domain Architecture
Description	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta).

ANFY1_MOUSE
NC score	0.205967 (rank : 67)	θ value	4.45536e-07 (rank : 37)
Query Neighborhood Hits	191	Target Neighborhood Hits	480	Shared Neighborhood Hits	53
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.203773 (rank : 68)	θ value	9.92553e-07 (rank : 39)
Query Neighborhood Hits	191	Target Neighborhood Hits	480	Shared Neighborhood Hits	51
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

EEA1_MOUSE
NC score	0.194297 (rank : 69)	θ value	1.69304e-06 (rank : 43)
Query Neighborhood Hits	191	Target Neighborhood Hits	1637	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

GP155_HUMAN
NC score	0.194293 (rank : 70)	θ value	0.000121331 (rank : 60)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

EEA1_HUMAN
NC score	0.180545 (rank : 71)	θ value	1.69304e-06 (rank : 42)
Query Neighborhood Hits	191	Target Neighborhood Hits	1796	Shared Neighborhood Hits	100
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TCPZ_MOUSE
NC score	0.174127 (rank : 72)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	10
SwissProt Accessions	P80317	Gene names	Cct6a, Cct6, Cctz, Cctz1
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1).

TCPZ_HUMAN
NC score	0.173790 (rank : 73)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	191	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	P40227, Q75LP4, Q96S46	Gene names	CCT6A, CCT6, CCTZ
Domain Architecture
Description	T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Tcp20) (HTR3) (Acute morphine dependence-related protein 2).

TCPD_HUMAN
NC score	0.168079 (rank : 74)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	191	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	P50991, O14870, Q96C51	Gene names	CCT4, CCTD, SRB
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding).

TCPD_MOUSE
NC score	0.166432 (rank : 75)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	P80315	Gene names	Cct4, Cctd
Domain Architecture
Description	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (A45).

TCPA_HUMAN
NC score	0.159252 (rank : 76)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P17987, Q15556, Q5TCM3	Gene names	CCT1, CCTA, TCP1
Domain Architecture
Description	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha).

TCPA1_MOUSE
NC score	0.158269 (rank : 77)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P11984	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha A (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1A) (TCP-1-A).

TCPA2_MOUSE
NC score	0.158258 (rank : 78)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	191	Target Neighborhood Hits	29	Shared Neighborhood Hits	10
SwissProt Accessions	P11983	Gene names	Cct1, Ccta, Tcp1
Domain Architecture
Description	T-complex protein 1 subunit alpha B (TCP-1-alpha) (CCT-alpha) (Tailless complex polypeptide 1B) (TCP-1-B).

TCPQ_HUMAN
NC score	0.156715 (rank : 79)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	191	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P50990	Gene names	CCT8, CCTQ, KIAA0002
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (NY-REN-15 antigen).

TCPQ_MOUSE
NC score	0.156328 (rank : 80)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	191	Target Neighborhood Hits	33	Shared Neighborhood Hits	10
SwissProt Accessions	P42932	Gene names	Cct8, Cctq
Domain Architecture
Description	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta).

PREX1_HUMAN
NC score	0.155700 (rank : 81)	θ value	0.000121331 (rank : 61)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RPGF4_MOUSE
NC score	0.120919 (rank : 82)	θ value	3.19293e-05 (rank : 56)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.120807 (rank : 83)	θ value	2.44474e-05 (rank : 55)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RUFY3_MOUSE
NC score	0.118202 (rank : 84)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	191	Target Neighborhood Hits	579	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.117273 (rank : 85)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	191	Target Neighborhood Hits	594	Shared Neighborhood Hits	31
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RNF34_MOUSE
NC score	0.116217 (rank : 86)	θ value	0.813845 (rank : 103)
Query Neighborhood Hits	191	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

CH60_MOUSE
NC score	0.112329 (rank : 87)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	191	Target Neighborhood Hits	43	Shared Neighborhood Hits	14
SwissProt Accessions	P63038, P19226, P19227, P97602	Gene names	Hspd1, Hsp60
Domain Architecture	No domain graphic available
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (HSP-65).

RNF34_HUMAN
NC score	0.105428 (rank : 88)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	191	Target Neighborhood Hits	153	Shared Neighborhood Hits	31
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

CH60_HUMAN
NC score	0.104496 (rank : 89)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	191	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P10809	Gene names	HSPD1, HSP60
Domain Architecture
Description	60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60).

MKKS_MOUSE
NC score	0.096040 (rank : 90)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	191	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JI70	Gene names	Mkks
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.

DEPD5_MOUSE
NC score	0.085326 (rank : 91)	θ value	0.0961366 (rank : 84)
Query Neighborhood Hits	191	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

RPGF5_MOUSE
NC score	0.085251 (rank : 92)	θ value	0.0961366 (rank : 85)
Query Neighborhood Hits	191	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

CASP_HUMAN
NC score	0.084836 (rank : 93)	θ value	0.0431538 (rank : 77)
Query Neighborhood Hits	191	Target Neighborhood Hits	1131	Shared Neighborhood Hits	50
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

DEPD5_HUMAN
NC score	0.084397 (rank : 94)	θ value	0.125558 (rank : 90)
Query Neighborhood Hits	191	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

RFFL_MOUSE
NC score	0.084022 (rank : 95)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	191	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

FARP2_HUMAN
NC score	0.083468 (rank : 96)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	191	Target Neighborhood Hits	240	Shared Neighborhood Hits	23
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RFFL_HUMAN
NC score	0.082369 (rank : 97)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	191	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

CASP_MOUSE
NC score	0.082055 (rank : 98)	θ value	0.125558 (rank : 88)
Query Neighborhood Hits	191	Target Neighborhood Hits	1152	Shared Neighborhood Hits	53
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

FARP2_MOUSE
NC score	0.081941 (rank : 99)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	191	Target Neighborhood Hits	209	Shared Neighborhood Hits	18
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CUTL1_MOUSE
NC score	0.081854 (rank : 100)	θ value	0.125558 (rank : 89)
Query Neighborhood Hits	191	Target Neighborhood Hits	1620	Shared Neighborhood Hits	65
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

FARP1_HUMAN
NC score	0.080880 (rank : 101)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	191	Target Neighborhood Hits	241	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

HAPIP_HUMAN
NC score	0.080408 (rank : 102)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

CUTL1_HUMAN
NC score	0.079841 (rank : 103)	θ value	0.0431538 (rank : 78)
Query Neighborhood Hits	191	Target Neighborhood Hits	1574	Shared Neighborhood Hits	57
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

RGS7_MOUSE
NC score	0.079306 (rank : 104)	θ value	0.00869519 (rank : 73)
Query Neighborhood Hits	191	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	O54829	Gene names	Rgs7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

RGS7_HUMAN
NC score	0.079008 (rank : 105)	θ value	0.00869519 (rank : 72)
Query Neighborhood Hits	191	Target Neighborhood Hits	82	Shared Neighborhood Hits	13
SwissProt Accessions	P49802, Q8TD66, Q8TD67, Q9UNU7, Q9Y6B9	Gene names	RGS7
Domain Architecture
Description	Regulator of G-protein signaling 7 (RGS7).

MKKS_HUMAN
NC score	0.078136 (rank : 106)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	191	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPJ1	Gene names	MKKS
Domain Architecture
Description	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Bardet- Biedl syndrome 6 protein).

ECT2_MOUSE
NC score	0.077492 (rank : 107)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.075708 (rank : 108)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	191	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RGS6_HUMAN
NC score	0.073894 (rank : 109)	θ value	0.0431538 (rank : 81)
Query Neighborhood Hits	191	Target Neighborhood Hits	80	Shared Neighborhood Hits	7
SwissProt Accessions	P49758, O75576, O75577, Q8TE13, Q8TE14, Q8TE15, Q8TE16, Q8TE17, Q8TE18, Q8TE19, Q8TE20, Q8TE21, Q8TE22, Q9Y245, Q9Y647	Gene names	RGS6
Domain Architecture
Description	Regulator of G-protein signaling 6 (RGS6) (S914).

RGS6_MOUSE
NC score	0.071575 (rank : 110)	θ value	0.0431538 (rank : 82)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z2H2, Q8BGI8	Gene names	Rgs6
Domain Architecture	No domain graphic available
Description	Regulator of G-protein signaling 6 (RGS6).

BBS10_HUMAN
NC score	0.070201 (rank : 111)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	191	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TAM1, Q96CW2, Q9H5D2	Gene names	BBS10, C12orf58
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein.

GNRP_HUMAN
NC score	0.069243 (rank : 112)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	191	Target Neighborhood Hits	239	Shared Neighborhood Hits	28
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CJ064_HUMAN
NC score	0.068853 (rank : 113)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	191	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

PKHG1_HUMAN
NC score	0.067734 (rank : 114)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	191	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

GNRP_MOUSE
NC score	0.067365 (rank : 115)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	191	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG5_HUMAN
NC score	0.066813 (rank : 116)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_MOUSE
NC score	0.065295 (rank : 117)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	191	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ZMYM3_MOUSE
NC score	0.064615 (rank : 118)	θ value	0.0961366 (rank : 87)
Query Neighborhood Hits	191	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

ZMYM3_HUMAN
NC score	0.064592 (rank : 119)	θ value	0.0961366 (rank : 86)
Query Neighborhood Hits	191	Target Neighborhood Hits	223	Shared Neighborhood Hits	11
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ARHGA_HUMAN
NC score	0.064445 (rank : 120)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	191	Target Neighborhood Hits	187	Shared Neighborhood Hits	17
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GCC2_MOUSE
NC score	0.064157 (rank : 121)	θ value	0.0431538 (rank : 80)
Query Neighborhood Hits	191	Target Neighborhood Hits	1619	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

MCF2L_MOUSE
NC score	0.063284 (rank : 122)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	191	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SWP70_HUMAN
NC score	0.062138 (rank : 123)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	191	Target Neighborhood Hits	973	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GOGA5_MOUSE
NC score	0.061694 (rank : 124)	θ value	0.279714 (rank : 92)
Query Neighborhood Hits	191	Target Neighborhood Hits	1434	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

INVO_HUMAN
NC score	0.061203 (rank : 125)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	191	Target Neighborhood Hits	636	Shared Neighborhood Hits	42
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

NGEF_HUMAN
NC score	0.061094 (rank : 126)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FNBP2_HUMAN
NC score	0.060563 (rank : 127)	θ value	0.0330416 (rank : 76)
Query Neighborhood Hits	191	Target Neighborhood Hits	432	Shared Neighborhood Hits	28
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

NGEF_MOUSE
NC score	0.060550 (rank : 128)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	191	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ITSN1_HUMAN
NC score	0.060195 (rank : 129)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	191	Target Neighborhood Hits	1757	Shared Neighborhood Hits	66
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHGF_HUMAN
NC score	0.060043 (rank : 130)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	191	Target Neighborhood Hits	214	Shared Neighborhood Hits	17
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BCR_HUMAN
NC score	0.059977 (rank : 131)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	191	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

GOGA5_HUMAN
NC score	0.059674 (rank : 132)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	191	Target Neighborhood Hits	1168	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

ITSN1_MOUSE
NC score	0.059457 (rank : 133)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	191	Target Neighborhood Hits	1669	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG4_HUMAN
NC score	0.059293 (rank : 134)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	191	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN2_MOUSE
NC score	0.058689 (rank : 135)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	191	Target Neighborhood Hits	1371	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

BBS10_MOUSE
NC score	0.058614 (rank : 136)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	191	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBI2	Gene names	Bbs10
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 10 protein homolog.

MCF2_HUMAN
NC score	0.058532 (rank : 137)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	21
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ABR_HUMAN
NC score	0.058509 (rank : 138)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	191	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHGG_HUMAN
NC score	0.058454 (rank : 139)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	191	Target Neighborhood Hits	129	Shared Neighborhood Hits	15
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ITSN2_HUMAN
NC score	0.058309 (rank : 140)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	191	Target Neighborhood Hits	1173	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG4_MOUSE
NC score	0.057631 (rank : 141)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	191	Target Neighborhood Hits	185	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG4_HUMAN
NC score	0.057290 (rank : 142)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	191	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SWP70_MOUSE
NC score	0.057259 (rank : 143)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	191	Target Neighborhood Hits	1097	Shared Neighborhood Hits	61
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CCDC6_HUMAN
NC score	0.057026 (rank : 144)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	191	Target Neighborhood Hits	723	Shared Neighborhood Hits	43
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

RABE2_MOUSE
NC score	0.056970 (rank : 145)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	191	Target Neighborhood Hits	598	Shared Neighborhood Hits	40
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

CRF_MOUSE
NC score	0.056875 (rank : 146)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	191	Target Neighborhood Hits	9	Shared Neighborhood Hits	1
SwissProt Accessions	Q8CIT0	Gene names	Crh
Domain Architecture	No domain graphic available
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

GOGA3_MOUSE
NC score	0.056093 (rank : 147)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	191	Target Neighborhood Hits	1437	Shared Neighborhood Hits	58
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

ARHG9_HUMAN
NC score	0.055696 (rank : 148)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	191	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG2_MOUSE
NC score	0.055505 (rank : 149)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	191	Target Neighborhood Hits	120	Shared Neighborhood Hits	15
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

DMD_MOUSE
NC score	0.055459 (rank : 150)	θ value	0.62314 (rank : 98)
Query Neighborhood Hits	191	Target Neighborhood Hits	1111	Shared Neighborhood Hits	50
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

ARHG9_MOUSE
NC score	0.055200 (rank : 151)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	191	Target Neighborhood Hits	234	Shared Neighborhood Hits	20
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

SYNE2_HUMAN
NC score	0.054953 (rank : 152)	θ value	0.813845 (rank : 105)
Query Neighborhood Hits	191	Target Neighborhood Hits	1323	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

SPTN5_HUMAN
NC score	0.054863 (rank : 153)	θ value	0.279714 (rank : 94)
Query Neighborhood Hits	191	Target Neighborhood Hits	674	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

GOGA2_HUMAN
NC score	0.054760 (rank : 154)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	191	Target Neighborhood Hits	856	Shared Neighborhood Hits	47
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

SRGP1_HUMAN
NC score	0.054574 (rank : 155)	θ value	0.0563607 (rank : 83)
Query Neighborhood Hits	191	Target Neighborhood Hits	390	Shared Neighborhood Hits	28
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ARHGG_MOUSE
NC score	0.054428 (rank : 156)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	191	Target Neighborhood Hits	152	Shared Neighborhood Hits	15
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

GOGA3_HUMAN
NC score	0.053943 (rank : 157)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	191	Target Neighborhood Hits	1317	Shared Neighborhood Hits	52
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA1_HUMAN
NC score	0.053780 (rank : 158)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	191	Target Neighborhood Hits	1222	Shared Neighborhood Hits	54
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

CCHCR_MOUSE
NC score	0.053519 (rank : 159)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	191	Target Neighborhood Hits	932	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CUTL2_MOUSE
NC score	0.053191 (rank : 160)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	191	Target Neighborhood Hits	771	Shared Neighborhood Hits	38
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CP135_HUMAN
NC score	0.053127 (rank : 161)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	191	Target Neighborhood Hits	1290	Shared Neighborhood Hits	48
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

GOGA2_MOUSE
NC score	0.053066 (rank : 162)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	191	Target Neighborhood Hits	944	Shared Neighborhood Hits	40
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

CE290_HUMAN
NC score	0.053065 (rank : 163)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	191	Target Neighborhood Hits	1553	Shared Neighborhood Hits	51
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

KNTC2_HUMAN
NC score	0.052867 (rank : 164)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	191	Target Neighborhood Hits	673	Shared Neighborhood Hits	39
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

CEP63_HUMAN
NC score	0.052839 (rank : 165)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	191	Target Neighborhood Hits	1005	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

MD1L1_MOUSE
NC score	0.052467 (rank : 166)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	191	Target Neighborhood Hits	1001	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

GOGA1_MOUSE
NC score	0.051856 (rank : 167)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	191	Target Neighborhood Hits	994	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

RABE2_HUMAN
NC score	0.051681 (rank : 168)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	191	Target Neighborhood Hits	545	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

KTN1_MOUSE
NC score	0.051359 (rank : 169)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	191	Target Neighborhood Hits	1324	Shared Neighborhood Hits	47
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CARD9_HUMAN
NC score	0.051307 (rank : 170)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	191	Target Neighborhood Hits	602	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

RPGF3_MOUSE
NC score	0.051243 (rank : 171)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	191	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

TSC1_HUMAN
NC score	0.051099 (rank : 172)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	191	Target Neighborhood Hits	765	Shared Neighborhood Hits	37
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

RBP24_HUMAN
NC score	0.051038 (rank : 173)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	191	Target Neighborhood Hits	1559	Shared Neighborhood Hits	56
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.051023 (rank : 174)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	191	Target Neighborhood Hits	1558	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RB6I2_MOUSE
NC score	0.051012 (rank : 175)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	191	Target Neighborhood Hits	1433	Shared Neighborhood Hits	49
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RPGF3_HUMAN
NC score	0.050931 (rank : 176)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	191	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RABE1_HUMAN
NC score	0.050795 (rank : 177)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	191	Target Neighborhood Hits	1104	Shared Neighborhood Hits	47
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

CYTSA_MOUSE
NC score	0.050628 (rank : 178)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	191	Target Neighborhood Hits	1104	Shared Neighborhood Hits	48
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

SPAG5_MOUSE
NC score	0.050616 (rank : 179)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	191	Target Neighborhood Hits	612	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

CNTRB_MOUSE
NC score	0.050600 (rank : 180)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	191	Target Neighborhood Hits	1029	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CF182_MOUSE
NC score	0.050512 (rank : 181)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	191	Target Neighborhood Hits	551	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

NUMA1_HUMAN
NC score	0.050317 (rank : 182)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	191	Target Neighborhood Hits	1523	Shared Neighborhood Hits	58
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RPGF5_HUMAN
NC score	0.050291 (rank : 183)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	191	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

SPTA1_HUMAN
NC score	0.050169 (rank : 184)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SYNE1_HUMAN
NC score	0.050066 (rank : 185)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	191	Target Neighborhood Hits	1484	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

DVL3_HUMAN
NC score	0.049665 (rank : 186)	θ value	0.47712 (rank : 95)
Query Neighborhood Hits	191	Target Neighborhood Hits	194	Shared Neighborhood Hits	20
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

CTDP1_HUMAN
NC score	0.048336 (rank : 187)	θ value	0.279714 (rank : 91)
Query Neighborhood Hits	191	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DMD_HUMAN
NC score	0.048112 (rank : 188)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	191	Target Neighborhood Hits	1135	Shared Neighborhood Hits	48
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DVL3_MOUSE
NC score	0.048069 (rank : 189)	θ value	0.47712 (rank : 96)
Query Neighborhood Hits	191	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

MY18A_HUMAN
NC score	0.047954 (rank : 190)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	191	Target Neighborhood Hits	1929	Shared Neighborhood Hits	75
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
NC score	0.046744 (rank : 191)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	191	Target Neighborhood Hits	1989	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RAI14_MOUSE
NC score	0.045463 (rank : 192)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	191	Target Neighborhood Hits	1505	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

MYH10_HUMAN
NC score	0.045021 (rank : 193)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	191	Target Neighborhood Hits	1620	Shared Neighborhood Hits	60
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SPTB2_HUMAN
NC score	0.045008 (rank : 194)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	40
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.044860 (rank : 195)	θ value	1.38821 (rank : 113)
Query Neighborhood Hits	191	Target Neighborhood Hits	770	Shared Neighborhood Hits	43
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MYH10_MOUSE
NC score	0.044357 (rank : 196)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	191	Target Neighborhood Hits	1612	Shared Neighborhood Hits	61
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH11_HUMAN
NC score	0.042602 (rank : 197)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	191	Target Neighborhood Hits	1806	Shared Neighborhood Hits	58
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
NC score	0.041997 (rank : 198)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	191	Target Neighborhood Hits	1777	Shared Neighborhood Hits	62
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

SRGP2_MOUSE
NC score	0.034322 (rank : 199)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	20
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

TGON2_HUMAN
NC score	0.033977 (rank : 200)	θ value	1.38821 (rank : 114)
Query Neighborhood Hits	191	Target Neighborhood Hits	1037	Shared Neighborhood Hits	26
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

SRGP2_HUMAN
NC score	0.033899 (rank : 201)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	191	Target Neighborhood Hits	331	Shared Neighborhood Hits	20
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

MYRIP_HUMAN
NC score	0.033018 (rank : 202)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	191	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SH3G2_HUMAN
NC score	0.032367 (rank : 203)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	191	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

GNAS3_MOUSE
NC score	0.032292 (rank : 204)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	191	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0F1, Q9QXW5, Q9Z0H2	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Neuroendocrine secretory protein 55 (NESP55) [Contains: LHAL tetrapeptide; GPIPIRRH peptide].

HAP1_MOUSE
NC score	0.032121 (rank : 205)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	191	Target Neighborhood Hits	388	Shared Neighborhood Hits	32
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

SH3G2_MOUSE
NC score	0.030474 (rank : 206)	θ value	0.813845 (rank : 104)
Query Neighborhood Hits	191	Target Neighborhood Hits	319	Shared Neighborhood Hits	19
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

MLL2_HUMAN
NC score	0.029870 (rank : 207)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	191	Target Neighborhood Hits	1788	Shared Neighborhood Hits	55
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ARP5_MOUSE
NC score	0.029825 (rank : 208)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	191	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	Q80US4, Q8BL26	Gene names	Actr5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5.

RRMJ3_HUMAN
NC score	0.029685 (rank : 209)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	191	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6	Gene names	FTSJ3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

DYHC_HUMAN
NC score	0.029162 (rank : 210)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	191	Target Neighborhood Hits	733	Shared Neighborhood Hits	40
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DVL2_MOUSE
NC score	0.028254 (rank : 211)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	191	Target Neighborhood Hits	233	Shared Neighborhood Hits	18
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.027550 (rank : 212)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	191	Target Neighborhood Hits	223	Shared Neighborhood Hits	17
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

UB7I4_MOUSE
NC score	0.027515 (rank : 213)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	191	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

LRC50_MOUSE
NC score	0.026936 (rank : 214)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	191	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

K0423_HUMAN
NC score	0.026684 (rank : 215)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	191	Target Neighborhood Hits	171	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

ARP5_HUMAN
NC score	0.026044 (rank : 216)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	191	Target Neighborhood Hits	107	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H9F9, Q86WF7, Q8IUY5, Q8N724, Q9BRN0, Q9BVB7	Gene names	ACTR5, ARP5
Domain Architecture	No domain graphic available
Description	Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16).

NOC2L_HUMAN
NC score	0.025948 (rank : 217)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	191	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

SAP_HUMAN
NC score	0.025583 (rank : 218)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	191	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

UB7I4_HUMAN
NC score	0.023593 (rank : 219)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	191	Target Neighborhood Hits	54	Shared Neighborhood Hits	6
SwissProt Accessions	P50876	Gene names	RNF144, KIAA0161, UBCE7IP4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

MBB1A_MOUSE
NC score	0.023472 (rank : 220)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	191	Target Neighborhood Hits	233	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

KLDC4_MOUSE
NC score	0.023365 (rank : 221)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	191	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q921I2, Q8CIK0	Gene names	Klhdc4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

DZIP1_HUMAN
NC score	0.023258 (rank : 222)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	191	Target Neighborhood Hits	675	Shared Neighborhood Hits	31
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

RNF31_HUMAN
NC score	0.023224 (rank : 223)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	191	Target Neighborhood Hits	110	Shared Neighborhood Hits	12
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

K1HB_HUMAN
NC score	0.022967 (rank : 224)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	191	Target Neighborhood Hits	470	Shared Neighborhood Hits	33
SwissProt Accessions	Q14525, O76010	Gene names	KRTHA3B, HHA3-II, HKA3B
Domain Architecture
Description	Keratin, type I cuticular Ha3-II (Hair keratin, type I Ha3-II).

CIZ1_HUMAN
NC score	0.022547 (rank : 225)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	191	Target Neighborhood Hits	359	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

NCOA6_MOUSE
NC score	0.021438 (rank : 226)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	191	Target Neighborhood Hits	1076	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PELP1_MOUSE
NC score	0.021175 (rank : 227)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	191	Target Neighborhood Hits	709	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

UN84B_HUMAN
NC score	0.019568 (rank : 228)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	191	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH99, O75156, Q6B4H1, Q7Z3E3	Gene names	UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2
Domain Architecture	No domain graphic available
Description	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP).

TRI32_HUMAN
NC score	0.018964 (rank : 229)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	191	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

SL9A3_HUMAN
NC score	0.018814 (rank : 230)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	191	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P48764	Gene names	SLC9A3, NHE3
Domain Architecture
Description	Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3).

TRI32_MOUSE
NC score	0.018721 (rank : 231)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	191	Target Neighborhood Hits	271	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

K1949_MOUSE
NC score	0.018622 (rank : 232)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	191	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

ATX2L_HUMAN
NC score	0.018439 (rank : 233)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	191	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

GMIP_MOUSE
NC score	0.017913 (rank : 234)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	191	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

BRD3_MOUSE
NC score	0.017697 (rank : 235)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	191	Target Neighborhood Hits	402	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

YTDC1_HUMAN
NC score	0.017385 (rank : 236)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	191	Target Neighborhood Hits	458	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

SLK_HUMAN
NC score	0.017068 (rank : 237)	θ value	0.279714 (rank : 93)
Query Neighborhood Hits	191	Target Neighborhood Hits	1775	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
NC score	0.015832 (rank : 238)	θ value	0.47712 (rank : 97)
Query Neighborhood Hits	191	Target Neighborhood Hits	1798	Shared Neighborhood Hits	51
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

C8AP2_HUMAN
NC score	0.015820 (rank : 239)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	191	Target Neighborhood Hits	548	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

WDR34_HUMAN
NC score	0.014977 (rank : 240)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	191	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q96EX3, Q5VXV4, Q9BV46	Gene names	WDR34
Domain Architecture
Description	WD repeat protein 34.

DDX21_MOUSE
NC score	0.014524 (rank : 241)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	191	Target Neighborhood Hits	350	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

CHD4_MOUSE
NC score	0.014351 (rank : 242)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	191	Target Neighborhood Hits	408	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

THAP4_HUMAN
NC score	0.014294 (rank : 243)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	191	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY91, Q53NU7, Q6GRN0, Q6IPJ3, Q9NW26, Q9Y325	Gene names	THAP4
Domain Architecture
Description	THAP domain-containing protein 4.

IQEC3_MOUSE
NC score	0.013999 (rank : 244)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	191	Target Neighborhood Hits	274	Shared Neighborhood Hits	18
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NFH_MOUSE
NC score	0.013955 (rank : 245)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	191	Target Neighborhood Hits	2247	Shared Neighborhood Hits	60
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

KCNK5_HUMAN
NC score	0.013657 (rank : 246)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	191	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

TISD_HUMAN
NC score	0.013317 (rank : 247)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	191	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

PTN23_HUMAN
NC score	0.013075 (rank : 248)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	191	Target Neighborhood Hits	646	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

EP400_MOUSE
NC score	0.013038 (rank : 249)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	191	Target Neighborhood Hits	592	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

ACO12_HUMAN
NC score	0.012269 (rank : 250)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	191	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WYK0	Gene names	ACOT12, CACH, CACH1, STARD12
Domain Architecture
Description	Acyl-coenzyme A thioesterase 12 (EC 3.1.2.1) (Acyl-CoA thioesterase 12) (Acyl-CoA thioester hydrolase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 12) (StARD12).

SRRM2_MOUSE
NC score	0.012228 (rank : 251)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	191	Target Neighborhood Hits	1470	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ZO2_MOUSE
NC score	0.011921 (rank : 252)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	191	Target Neighborhood Hits	296	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

NSD1_MOUSE
NC score	0.011624 (rank : 253)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	191	Target Neighborhood Hits	472	Shared Neighborhood Hits	19
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

IMB1_MOUSE
NC score	0.011205 (rank : 254)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	191	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB1_HUMAN
NC score	0.011153 (rank : 255)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	191	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

CITE4_MOUSE
NC score	0.011051 (rank : 256)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	191	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUL8, Q66JX0, Q8R176, Q9CZV4	Gene names	Cited4, Mrg2
Domain Architecture	No domain graphic available
Description	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG- 2).

VCAM1_MOUSE
NC score	0.010064 (rank : 257)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	191	Target Neighborhood Hits	320	Shared Neighborhood Hits	3
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

AIRE_HUMAN
NC score	0.009722 (rank : 258)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	191	Target Neighborhood Hits	144	Shared Neighborhood Hits	6
SwissProt Accessions	O43918, O43922, O43932, O75745	Gene names	AIRE, APECED
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein).

CAC1I_HUMAN
NC score	0.009119 (rank : 259)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	191	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

RIMS1_HUMAN
NC score	0.007752 (rank : 260)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	191	Target Neighborhood Hits	437	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

K1196_HUMAN
NC score	0.007558 (rank : 261)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	191	Target Neighborhood Hits	618	Shared Neighborhood Hits	9
SwissProt Accessions	Q96KM6, Q9ULM4	Gene names	KIAA1196
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1196.

SON_MOUSE
NC score	0.006618 (rank : 262)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	191	Target Neighborhood Hits	957	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

DDX10_MOUSE
NC score	0.005589 (rank : 263)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	191	Target Neighborhood Hits	233	Shared Neighborhood Hits	10
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

ZN507_HUMAN
NC score	0.002858 (rank : 264)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	191	Target Neighborhood Hits	739	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

TAOK2_HUMAN
NC score	0.002477 (rank : 265)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	191	Target Neighborhood Hits	1172	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CADH3_HUMAN
NC score	0.001792 (rank : 266)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	191	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	P22223	Gene names	CDH3, CDHP
Domain Architecture
Description	Cadherin-3 precursor (Placental-cadherin) (P-cadherin).

E2AK4_HUMAN
NC score	0.001712 (rank : 267)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	191	Target Neighborhood Hits	1012	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

NEK1_MOUSE
NC score	0.001433 (rank : 268)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	191	Target Neighborhood Hits	1311	Shared Neighborhood Hits	29
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ZN323_HUMAN
NC score	-0.000378 (rank : 269)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	191	Target Neighborhood Hits	802	Shared Neighborhood Hits	21
SwissProt Accessions	Q96LW9, Q8WWS5	Gene names	ZNF323
Domain Architecture
Description	Zinc finger protein 323.

ZNF70_HUMAN
NC score	-0.000553 (rank : 270)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	191	Target Neighborhood Hits	760	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

STK4_MOUSE
NC score	-0.002216 (rank : 271)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	191	Target Neighborhood Hits	873	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	-0.002421 (rank : 272)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	191	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

PRD14_HUMAN
NC score	-0.002465 (rank : 273)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	191	Target Neighborhood Hits	757	Shared Neighborhood Hits	9
SwissProt Accessions	Q9GZV8, Q86UX9	Gene names	PRDM14
Domain Architecture
Description	PR domain zinc finger protein 14 (PR domain-containing protein 14).

ZNF8_HUMAN
NC score	-0.003524 (rank : 274)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	191	Target Neighborhood Hits	748	Shared Neighborhood Hits	9
SwissProt Accessions	P17098, Q6PI99	Gene names	ZNF8
Domain Architecture	No domain graphic available
Description	Zinc finger protein 8 (Zinc finger protein HF.18).