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Network neighborhood for query Sequence : ABR_HUMAN

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ABR_HUMAN
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ABR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	166
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
θ value	0 (rank : 2)	NC score	0.980929 (rank : 2)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	134
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CHIN_MOUSE
θ value	6.38894e-30 (rank : 3)	NC score	0.700094 (rank : 17)
Query Neighborhood Hits	166	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
θ value	5.40856e-29 (rank : 4)	NC score	0.698158 (rank : 18)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG12_MOUSE
θ value	1.2049e-28 (rank : 5)	NC score	0.743363 (rank : 5)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_HUMAN
θ value	3.87602e-27 (rank : 6)	NC score	0.745987 (rank : 4)
Query Neighborhood Hits	166	Target Neighborhood Hits	190	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG09_HUMAN
θ value	1.24688e-25 (rank : 7)	NC score	0.768006 (rank : 3)
Query Neighborhood Hits	166	Target Neighborhood Hits	186	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

CHIO_MOUSE
θ value	1.62847e-25 (rank : 8)	NC score	0.723419 (rank : 12)
Query Neighborhood Hits	166	Target Neighborhood Hits	130	Shared Neighborhood Hits	73
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_HUMAN
θ value	6.18819e-25 (rank : 9)	NC score	0.694382 (rank : 19)
Query Neighborhood Hits	166	Target Neighborhood Hits	220	Shared Neighborhood Hits	74
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TCGAP_HUMAN
θ value	6.84181e-24 (rank : 10)	NC score	0.647366 (rank : 36)
Query Neighborhood Hits	166	Target Neighborhood Hits	872	Shared Neighborhood Hits	94
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	8.93572e-24 (rank : 11)	NC score	0.727479 (rank : 11)
Query Neighborhood Hits	166	Target Neighborhood Hits	409	Shared Neighborhood Hits	92
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

3BP1_HUMAN
θ value	1.5242e-23 (rank : 12)	NC score	0.717347 (rank : 14)
Query Neighborhood Hits	166	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RGAP1_HUMAN
θ value	7.56453e-23 (rank : 13)	NC score	0.738423 (rank : 6)
Query Neighborhood Hits	166	Target Neighborhood Hits	189	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GRLF1_HUMAN
θ value	1.29031e-22 (rank : 14)	NC score	0.719266 (rank : 13)
Query Neighborhood Hits	166	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RBP1_HUMAN
θ value	8.36355e-22 (rank : 15)	NC score	0.648211 (rank : 35)
Query Neighborhood Hits	166	Target Neighborhood Hits	521	Shared Neighborhood Hits	63
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG05_MOUSE
θ value	8.36355e-22 (rank : 16)	NC score	0.693232 (rank : 21)
Query Neighborhood Hits	166	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RGAP1_MOUSE
θ value	1.09232e-21 (rank : 17)	NC score	0.733942 (rank : 7)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RBP1_MOUSE
θ value	5.42112e-21 (rank : 18)	NC score	0.663731 (rank : 31)
Query Neighborhood Hits	166	Target Neighborhood Hits	493	Shared Neighborhood Hits	63
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

ARHGA_HUMAN
θ value	7.0802e-21 (rank : 19)	NC score	0.460761 (rank : 60)
Query Neighborhood Hits	166	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

RHG05_HUMAN
θ value	2.06002e-20 (rank : 20)	NC score	0.684868 (rank : 23)
Query Neighborhood Hits	166	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

ARHGA_MOUSE
θ value	4.58923e-20 (rank : 21)	NC score	0.461926 (rank : 59)
Query Neighborhood Hits	166	Target Neighborhood Hits	125	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GMIP_HUMAN
θ value	4.58923e-20 (rank : 22)	NC score	0.729183 (rank : 9)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

MYO9B_MOUSE
θ value	7.82807e-20 (rank : 23)	NC score	0.381852 (rank : 79)
Query Neighborhood Hits	166	Target Neighborhood Hits	311	Shared Neighborhood Hits	74
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

3BP1_MOUSE
θ value	1.33526e-19 (rank : 24)	NC score	0.728177 (rank : 10)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	68
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GMIP_MOUSE
θ value	1.13037e-18 (rank : 25)	NC score	0.731693 (rank : 8)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	73
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

MYO9B_HUMAN
θ value	1.13037e-18 (rank : 26)	NC score	0.376025 (rank : 80)
Query Neighborhood Hits	166	Target Neighborhood Hits	641	Shared Neighborhood Hits	80
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RHG26_HUMAN
θ value	1.13037e-18 (rank : 27)	NC score	0.672942 (rank : 29)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG04_HUMAN
θ value	1.47631e-18 (rank : 28)	NC score	0.677225 (rank : 27)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	80
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PREX1_HUMAN
θ value	1.92812e-18 (rank : 29)	NC score	0.442242 (rank : 61)
Query Neighborhood Hits	166	Target Neighborhood Hits	177	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SRGP2_HUMAN
θ value	4.29542e-18 (rank : 30)	NC score	0.657183 (rank : 33)
Query Neighborhood Hits	166	Target Neighborhood Hits	331	Shared Neighborhood Hits	80
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
θ value	7.32683e-18 (rank : 31)	NC score	0.647221 (rank : 37)
Query Neighborhood Hits	166	Target Neighborhood Hits	390	Shared Neighborhood Hits	80
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ECT2_HUMAN
θ value	1.24977e-17 (rank : 32)	NC score	0.467633 (rank : 58)
Query Neighborhood Hits	166	Target Neighborhood Hits	98	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	2.7842e-17 (rank : 33)	NC score	0.474651 (rank : 57)
Query Neighborhood Hits	166	Target Neighborhood Hits	98	Shared Neighborhood Hits	64
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SRGP2_MOUSE
θ value	2.7842e-17 (rank : 34)	NC score	0.650735 (rank : 34)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	80
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

GNRP_MOUSE
θ value	4.74913e-17 (rank : 35)	NC score	0.370394 (rank : 82)
Query Neighborhood Hits	166	Target Neighborhood Hits	191	Shared Neighborhood Hits	59
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FNBP2_HUMAN
θ value	6.20254e-17 (rank : 36)	NC score	0.640238 (rank : 38)
Query Neighborhood Hits	166	Target Neighborhood Hits	432	Shared Neighborhood Hits	79
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG25_MOUSE
θ value	6.20254e-17 (rank : 37)	NC score	0.658529 (rank : 32)
Query Neighborhood Hits	166	Target Neighborhood Hits	492	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
θ value	1.38178e-16 (rank : 38)	NC score	0.634399 (rank : 39)
Query Neighborhood Hits	166	Target Neighborhood Hits	550	Shared Neighborhood Hits	72
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

GNRP_HUMAN
θ value	3.07829e-16 (rank : 39)	NC score	0.349998 (rank : 87)
Query Neighborhood Hits	166	Target Neighborhood Hits	239	Shared Neighborhood Hits	59
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RHG06_MOUSE
θ value	5.25075e-16 (rank : 40)	NC score	0.709969 (rank : 16)
Query Neighborhood Hits	166	Target Neighborhood Hits	105	Shared Neighborhood Hits	63
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

OPHN1_HUMAN
θ value	6.85773e-16 (rank : 41)	NC score	0.679552 (rank : 25)
Query Neighborhood Hits	166	Target Neighborhood Hits	161	Shared Neighborhood Hits	63
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	1.52774e-15 (rank : 42)	NC score	0.678798 (rank : 26)
Query Neighborhood Hits	166	Target Neighborhood Hits	174	Shared Neighborhood Hits	63
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG18_HUMAN
θ value	2.60593e-15 (rank : 43)	NC score	0.693869 (rank : 20)
Query Neighborhood Hits	166	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG06_HUMAN
θ value	4.44505e-15 (rank : 44)	NC score	0.710661 (rank : 15)
Query Neighborhood Hits	166	Target Neighborhood Hits	114	Shared Neighborhood Hits	65
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CEND2_HUMAN
θ value	5.8054e-15 (rank : 45)	NC score	0.580762 (rank : 45)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

FGD4_HUMAN
θ value	9.90251e-15 (rank : 46)	NC score	0.422194 (rank : 66)
Query Neighborhood Hits	166	Target Neighborhood Hits	219	Shared Neighborhood Hits	69
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CEND1_MOUSE
θ value	2.20605e-14 (rank : 47)	NC score	0.502393 (rank : 53)
Query Neighborhood Hits	166	Target Neighborhood Hits	260	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

RHG07_MOUSE
θ value	2.20605e-14 (rank : 48)	NC score	0.618681 (rank : 40)
Query Neighborhood Hits	166	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG18_MOUSE
θ value	2.20605e-14 (rank : 49)	NC score	0.692033 (rank : 22)
Query Neighborhood Hits	166	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

FGD4_MOUSE
θ value	2.88119e-14 (rank : 50)	NC score	0.423977 (rank : 64)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	68
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

RHG08_HUMAN
θ value	6.41864e-14 (rank : 51)	NC score	0.669138 (rank : 30)
Query Neighborhood Hits	166	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_MOUSE
θ value	6.41864e-14 (rank : 52)	NC score	0.673291 (rank : 28)
Query Neighborhood Hits	166	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

CEND3_MOUSE
θ value	8.38298e-14 (rank : 53)	NC score	0.545812 (rank : 51)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

RHG07_HUMAN
θ value	1.86753e-13 (rank : 54)	NC score	0.613060 (rank : 41)
Query Neighborhood Hits	166	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

FGD2_HUMAN
θ value	3.18553e-13 (rank : 55)	NC score	0.425838 (rank : 63)
Query Neighborhood Hits	166	Target Neighborhood Hits	151	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

CEND1_HUMAN
θ value	4.16044e-13 (rank : 56)	NC score	0.480966 (rank : 55)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND3_HUMAN
θ value	4.16044e-13 (rank : 57)	NC score	0.536194 (rank : 52)
Query Neighborhood Hits	166	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

FGD6_HUMAN
θ value	2.0648e-12 (rank : 58)	NC score	0.403801 (rank : 70)
Query Neighborhood Hits	166	Target Neighborhood Hits	237	Shared Neighborhood Hits	63
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

RHG01_HUMAN
θ value	2.69671e-12 (rank : 59)	NC score	0.682250 (rank : 24)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

STAR8_MOUSE
θ value	4.59992e-12 (rank : 60)	NC score	0.582397 (rank : 44)
Query Neighborhood Hits	166	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
θ value	7.84624e-12 (rank : 61)	NC score	0.575175 (rank : 47)
Query Neighborhood Hits	166	Target Neighborhood Hits	216	Shared Neighborhood Hits	64
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

FGD3_MOUSE
θ value	1.02475e-11 (rank : 62)	NC score	0.435938 (rank : 62)
Query Neighborhood Hits	166	Target Neighborhood Hits	257	Shared Neighborhood Hits	65
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

STA13_HUMAN
θ value	1.02475e-11 (rank : 63)	NC score	0.576074 (rank : 46)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

FGD1_MOUSE
θ value	1.33837e-11 (rank : 64)	NC score	0.409602 (rank : 69)
Query Neighborhood Hits	166	Target Neighborhood Hits	387	Shared Neighborhood Hits	69
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
θ value	1.33837e-11 (rank : 65)	NC score	0.417675 (rank : 67)
Query Neighborhood Hits	166	Target Neighborhood Hits	163	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_HUMAN
θ value	1.74796e-11 (rank : 66)	NC score	0.410909 (rank : 68)
Query Neighborhood Hits	166	Target Neighborhood Hits	367	Shared Neighborhood Hits	67
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FARP2_HUMAN
θ value	5.08577e-11 (rank : 67)	NC score	0.286561 (rank : 111)
Query Neighborhood Hits	166	Target Neighborhood Hits	240	Shared Neighborhood Hits	66
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

STA13_MOUSE
θ value	6.64225e-11 (rank : 68)	NC score	0.566544 (rank : 48)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

FGD6_MOUSE
θ value	1.133e-10 (rank : 69)	NC score	0.401997 (rank : 71)
Query Neighborhood Hits	166	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FARP2_MOUSE
θ value	2.52405e-10 (rank : 70)	NC score	0.297544 (rank : 103)
Query Neighborhood Hits	166	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CE005_HUMAN
θ value	5.62301e-10 (rank : 71)	NC score	0.558649 (rank : 49)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

FGD3_HUMAN
θ value	5.62301e-10 (rank : 72)	NC score	0.423757 (rank : 65)
Query Neighborhood Hits	166	Target Neighborhood Hits	249	Shared Neighborhood Hits	65
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

CE005_MOUSE
θ value	7.34386e-10 (rank : 73)	NC score	0.555577 (rank : 50)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

ARHG8_HUMAN
θ value	1.38499e-08 (rank : 74)	NC score	0.372490 (rank : 81)
Query Neighborhood Hits	166	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

VAV3_MOUSE
θ value	1.38499e-08 (rank : 75)	NC score	0.319851 (rank : 97)
Query Neighborhood Hits	166	Target Neighborhood Hits	404	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

P85A_HUMAN
θ value	5.26297e-08 (rank : 76)	NC score	0.398611 (rank : 73)
Query Neighborhood Hits	166	Target Neighborhood Hits	479	Shared Neighborhood Hits	71
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	5.26297e-08 (rank : 77)	NC score	0.387956 (rank : 78)
Query Neighborhood Hits	166	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TAGAP_HUMAN
θ value	5.26297e-08 (rank : 78)	NC score	0.598399 (rank : 42)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ARHG9_HUMAN
θ value	8.97725e-08 (rank : 79)	NC score	0.394799 (rank : 77)
Query Neighborhood Hits	166	Target Neighborhood Hits	235	Shared Neighborhood Hits	69
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	8.97725e-08 (rank : 80)	NC score	0.394885 (rank : 76)
Query Neighborhood Hits	166	Target Neighborhood Hits	234	Shared Neighborhood Hits	69
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ITSN1_MOUSE
θ value	1.53129e-07 (rank : 81)	NC score	0.256873 (rank : 121)
Query Neighborhood Hits	166	Target Neighborhood Hits	1669	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TIAM1_MOUSE
θ value	1.99992e-07 (rank : 82)	NC score	0.365810 (rank : 84)
Query Neighborhood Hits	166	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV3_HUMAN
θ value	1.99992e-07 (rank : 83)	NC score	0.317823 (rank : 98)
Query Neighborhood Hits	166	Target Neighborhood Hits	398	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PKHG1_HUMAN
θ value	2.61198e-07 (rank : 84)	NC score	0.396202 (rank : 75)
Query Neighborhood Hits	166	Target Neighborhood Hits	174	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG3_HUMAN
θ value	5.81887e-07 (rank : 85)	NC score	0.366353 (rank : 83)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

TAGAP_MOUSE
θ value	9.92553e-07 (rank : 86)	NC score	0.596607 (rank : 43)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

FGD5_HUMAN
θ value	1.29631e-06 (rank : 87)	NC score	0.329672 (rank : 93)
Query Neighborhood Hits	166	Target Neighborhood Hits	235	Shared Neighborhood Hits	48
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ITSN1_HUMAN
θ value	1.29631e-06 (rank : 88)	NC score	0.257735 (rank : 119)
Query Neighborhood Hits	166	Target Neighborhood Hits	1757	Shared Neighborhood Hits	101
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG4_MOUSE
θ value	1.69304e-06 (rank : 89)	NC score	0.397978 (rank : 74)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
θ value	2.21117e-06 (rank : 90)	NC score	0.400735 (rank : 72)
Query Neighborhood Hits	166	Target Neighborhood Hits	242	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG3_MOUSE
θ value	2.88788e-06 (rank : 91)	NC score	0.364262 (rank : 86)
Query Neighborhood Hits	166	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGG_MOUSE
θ value	3.77169e-06 (rank : 92)	NC score	0.337699 (rank : 91)
Query Neighborhood Hits	166	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_MOUSE
θ value	3.77169e-06 (rank : 93)	NC score	0.328279 (rank : 94)
Query Neighborhood Hits	166	Target Neighborhood Hits	435	Shared Neighborhood Hits	78
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	6.43352e-06 (rank : 94)	NC score	0.320625 (rank : 96)
Query Neighborhood Hits	166	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

K1688_HUMAN
θ value	6.43352e-06 (rank : 95)	NC score	0.478854 (rank : 56)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

MCF2_HUMAN
θ value	6.43352e-06 (rank : 96)	NC score	0.347114 (rank : 89)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

TIAM1_HUMAN
θ value	6.43352e-06 (rank : 97)	NC score	0.364969 (rank : 85)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG8_MOUSE
θ value	8.40245e-06 (rank : 98)	NC score	0.338338 (rank : 90)
Query Neighborhood Hits	166	Target Neighborhood Hits	79	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

DUET_HUMAN
θ value	1.43324e-05 (rank : 99)	NC score	0.121300 (rank : 141)
Query Neighborhood Hits	166	Target Neighborhood Hits	1220	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

K1688_MOUSE
θ value	1.43324e-05 (rank : 100)	NC score	0.486501 (rank : 54)
Query Neighborhood Hits	166	Target Neighborhood Hits	188	Shared Neighborhood Hits	60
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

ITSN2_HUMAN
θ value	1.87187e-05 (rank : 101)	NC score	0.271719 (rank : 115)
Query Neighborhood Hits	166	Target Neighborhood Hits	1173	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	2.44474e-05 (rank : 102)	NC score	0.257028 (rank : 120)
Query Neighborhood Hits	166	Target Neighborhood Hits	1371	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_MOUSE
θ value	2.44474e-05 (rank : 103)	NC score	0.301797 (rank : 102)
Query Neighborhood Hits	166	Target Neighborhood Hits	430	Shared Neighborhood Hits	86
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

HAPIP_HUMAN
θ value	4.1701e-05 (rank : 104)	NC score	0.292966 (rank : 106)
Query Neighborhood Hits	166	Target Neighborhood Hits	350	Shared Neighborhood Hits	65
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

P85B_HUMAN
θ value	7.1131e-05 (rank : 105)	NC score	0.157177 (rank : 131)
Query Neighborhood Hits	166	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ARHGG_HUMAN
θ value	9.29e-05 (rank : 106)	NC score	0.334225 (rank : 92)
Query Neighborhood Hits	166	Target Neighborhood Hits	129	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG5_HUMAN
θ value	0.000121331 (rank : 107)	NC score	0.347816 (rank : 88)
Query Neighborhood Hits	166	Target Neighborhood Hits	172	Shared Neighborhood Hits	66
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

VAV_HUMAN
θ value	0.000158464 (rank : 108)	NC score	0.288723 (rank : 108)
Query Neighborhood Hits	166	Target Neighborhood Hits	452	Shared Neighborhood Hits	88
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

FGD5_MOUSE
θ value	0.000270298 (rank : 109)	NC score	0.315659 (rank : 99)
Query Neighborhood Hits	166	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

OBSCN_HUMAN
θ value	0.000602161 (rank : 110)	NC score	0.053799 (rank : 251)
Query Neighborhood Hits	166	Target Neighborhood Hits	1931	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

P85B_MOUSE
θ value	0.000602161 (rank : 111)	NC score	0.132020 (rank : 139)
Query Neighborhood Hits	166	Target Neighborhood Hits	519	Shared Neighborhood Hits	32
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TRIO_HUMAN
θ value	0.00102713 (rank : 112)	NC score	0.111831 (rank : 143)
Query Neighborhood Hits	166	Target Neighborhood Hits	1580	Shared Neighborhood Hits	71
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

FARP1_HUMAN
θ value	0.00390308 (rank : 113)	NC score	0.249598 (rank : 122)
Query Neighborhood Hits	166	Target Neighborhood Hits	241	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

OCRL_HUMAN
θ value	0.00665767 (rank : 114)	NC score	0.284636 (rank : 113)
Query Neighborhood Hits	166	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

I5P2_HUMAN
θ value	0.0113563 (rank : 115)	NC score	0.294687 (rank : 105)
Query Neighborhood Hits	166	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

MCF2L_MOUSE
θ value	0.0113563 (rank : 116)	NC score	0.313710 (rank : 101)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

UN13A_HUMAN
θ value	0.0736092 (rank : 117)	NC score	0.099996 (rank : 157)
Query Neighborhood Hits	166	Target Neighborhood Hits	285	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	0.0736092 (rank : 118)	NC score	0.099451 (rank : 158)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	31
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	0.125558 (rank : 119)	NC score	0.096412 (rank : 164)
Query Neighborhood Hits	166	Target Neighborhood Hits	210	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

ARHG6_HUMAN
θ value	0.163984 (rank : 120)	NC score	0.260760 (rank : 117)
Query Neighborhood Hits	166	Target Neighborhood Hits	376	Shared Neighborhood Hits	63
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_MOUSE
θ value	0.21417 (rank : 121)	NC score	0.295866 (rank : 104)
Query Neighborhood Hits	166	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG1_HUMAN
θ value	0.365318 (rank : 122)	NC score	0.261058 (rank : 116)
Query Neighborhood Hits	166	Target Neighborhood Hits	176	Shared Neighborhood Hits	56
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

NGEF_MOUSE
θ value	0.365318 (rank : 123)	NC score	0.314808 (rank : 100)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	64
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG4_HUMAN
θ value	0.365318 (rank : 124)	NC score	0.273219 (rank : 114)
Query Neighborhood Hits	166	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

NGEF_HUMAN
θ value	0.47712 (rank : 125)	NC score	0.324301 (rank : 95)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG1_MOUSE
θ value	0.813845 (rank : 126)	NC score	0.243670 (rank : 124)
Query Neighborhood Hits	166	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

KPCA_HUMAN
θ value	0.813845 (rank : 127)	NC score	0.021708 (rank : 266)
Query Neighborhood Hits	166	Target Neighborhood Hits	1070	Shared Neighborhood Hits	35
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ARHG6_MOUSE
θ value	1.06291 (rank : 128)	NC score	0.248469 (rank : 123)
Query Neighborhood Hits	166	Target Neighborhood Hits	394	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ECHB_MOUSE
θ value	1.06291 (rank : 129)	NC score	0.011916 (rank : 279)
Query Neighborhood Hits	166	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

DOC2G_MOUSE
θ value	1.38821 (rank : 130)	NC score	0.018081 (rank : 271)
Query Neighborhood Hits	166	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SUCR1_HUMAN
θ value	1.38821 (rank : 131)	NC score	-0.004020 (rank : 298)
Query Neighborhood Hits	166	Target Neighborhood Hits	696	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXA5, Q8TDQ8	Gene names	SUCNR1, GPR91
Domain Architecture
Description	Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like).

ARHG7_HUMAN
θ value	1.81305 (rank : 132)	NC score	0.290048 (rank : 107)
Query Neighborhood Hits	166	Target Neighborhood Hits	347	Shared Neighborhood Hits	71
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GP158_MOUSE
θ value	1.81305 (rank : 133)	NC score	0.011912 (rank : 280)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C419, Q8CHB0	Gene names	Gpr158, Kiaa1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

BSN_MOUSE
θ value	2.36792 (rank : 134)	NC score	0.024929 (rank : 264)
Query Neighborhood Hits	166	Target Neighborhood Hits	2057	Shared Neighborhood Hits	29
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

JPH4_HUMAN
θ value	2.36792 (rank : 135)	NC score	0.013683 (rank : 273)
Query Neighborhood Hits	166	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH4_MOUSE
θ value	2.36792 (rank : 136)	NC score	0.013417 (rank : 274)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

AMPD3_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.012523 (rank : 278)
Query Neighborhood Hits	166	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q01432	Gene names	AMPD3
Domain Architecture
Description	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase).

AMPD3_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.012614 (rank : 277)
Query Neighborhood Hits	166	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	O08739, O88692	Gene names	Ampd3
Domain Architecture
Description	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (AMP deaminase H-type) (Heart-type AMPD).

KPCA_MOUSE
θ value	3.0926 (rank : 139)	NC score	0.019860 (rank : 270)
Query Neighborhood Hits	166	Target Neighborhood Hits	1067	Shared Neighborhood Hits	35
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ARHG2_HUMAN
θ value	4.03905 (rank : 140)	NC score	0.219623 (rank : 126)
Query Neighborhood Hits	166	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

BSN_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.020420 (rank : 267)
Query Neighborhood Hits	166	Target Neighborhood Hits	1537	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CSKI1_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.007112 (rank : 289)
Query Neighborhood Hits	166	Target Neighborhood Hits	997	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

AKAP2_HUMAN
θ value	5.27518 (rank : 143)	NC score	0.008535 (rank : 287)
Query Neighborhood Hits	166	Target Neighborhood Hits	507	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

CCDC7_HUMAN
θ value	5.27518 (rank : 144)	NC score	0.008577 (rank : 286)
Query Neighborhood Hits	166	Target Neighborhood Hits	253	Shared Neighborhood Hits	4
SwissProt Accessions	Q96M83, Q8IVQ0, Q8NEQ0	Gene names	CCDC7
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 7.

FA50A_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.010195 (rank : 283)
Query Neighborhood Hits	166	Target Neighborhood Hits	264	Shared Neighborhood Hits	6
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

M4K5_HUMAN
θ value	5.27518 (rank : 146)	NC score	-0.003836 (rank : 297)
Query Neighborhood Hits	166	Target Neighborhood Hits	845	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PA24F_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.014220 (rank : 272)
Query Neighborhood Hits	166	Target Neighborhood Hits	93	Shared Neighborhood Hits	14
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

ARHGB_HUMAN
θ value	6.88961 (rank : 148)	NC score	0.258425 (rank : 118)
Query Neighborhood Hits	166	Target Neighborhood Hits	375	Shared Neighborhood Hits	61
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

CASZ1_HUMAN
θ value	6.88961 (rank : 149)	NC score	0.007509 (rank : 288)
Query Neighborhood Hits	166	Target Neighborhood Hits	473	Shared Neighborhood Hits	4
SwissProt Accessions	Q86V15, Q5T9S1, Q8WX49, Q8WX50, Q9BT16, Q9NXC6	Gene names	CASZ1, CST, ZNF693
Domain Architecture	No domain graphic available
Description	Castor homolog 1 zinc finger protein (Castor-related protein) (Zinc finger protein 693).

EVI1_MOUSE
θ value	6.88961 (rank : 150)	NC score	-0.007972 (rank : 299)
Query Neighborhood Hits	166	Target Neighborhood Hits	826	Shared Neighborhood Hits	6
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

FA50A_MOUSE
θ value	6.88961 (rank : 151)	NC score	0.010073 (rank : 284)
Query Neighborhood Hits	166	Target Neighborhood Hits	293	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

JPH2_HUMAN
θ value	6.88961 (rank : 152)	NC score	0.008969 (rank : 285)
Query Neighborhood Hits	166	Target Neighborhood Hits	639	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

KPCB_MOUSE
θ value	6.88961 (rank : 153)	NC score	0.020384 (rank : 268)
Query Neighborhood Hits	166	Target Neighborhood Hits	1117	Shared Neighborhood Hits	33
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

NXF2_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.012648 (rank : 276)
Query Neighborhood Hits	166	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9GZY0, Q9BXU4, Q9NSS1, Q9NX66	Gene names	NXF2, TAPL2
Domain Architecture
Description	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2).

ABCA9_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.000472 (rank : 295)
Query Neighborhood Hits	166	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

BCL3_MOUSE
θ value	8.99809 (rank : 156)	NC score	-0.002821 (rank : 296)
Query Neighborhood Hits	166	Target Neighborhood Hits	388	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

FZD6_HUMAN
θ value	8.99809 (rank : 157)	NC score	0.000508 (rank : 294)
Query Neighborhood Hits	166	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

KPCB_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.020004 (rank : 269)
Query Neighborhood Hits	166	Target Neighborhood Hits	1121	Shared Neighborhood Hits	33
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MMP15_MOUSE
θ value	8.99809 (rank : 159)	NC score	0.001078 (rank : 293)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

NRDC_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.004116 (rank : 291)
Query Neighborhood Hits	166	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

PA24E_MOUSE
θ value	8.99809 (rank : 161)	NC score	0.011106 (rank : 281)
Query Neighborhood Hits	166	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24F_HUMAN
θ value	8.99809 (rank : 162)	NC score	0.013384 (rank : 275)
Query Neighborhood Hits	166	Target Neighborhood Hits	78	Shared Neighborhood Hits	15
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PRC1_HUMAN
θ value	8.99809 (rank : 163)	NC score	0.010445 (rank : 282)
Query Neighborhood Hits	166	Target Neighborhood Hits	328	Shared Neighborhood Hits	9
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

SCG1_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.005175 (rank : 290)
Query Neighborhood Hits	166	Target Neighborhood Hits	156	Shared Neighborhood Hits	4
SwissProt Accessions	P05060, Q9BQV6, Q9UJA6	Gene names	CHGB, SCG1
Domain Architecture
Description	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide].

TAF4_HUMAN
θ value	8.99809 (rank : 165)	NC score	0.024676 (rank : 265)
Query Neighborhood Hits	166	Target Neighborhood Hits	687	Shared Neighborhood Hits	16
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TBCD8_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.003612 (rank : 292)
Query Neighborhood Hits	166	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	O95759, Q9UQ32	Gene names	TBC1D8, VRP
Domain Architecture
Description	TBC1 domain family member 8 (Vascular Rab-GAP/TBC-containing protein) (AD 3).

ABI1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.067066 (rank : 207)
Query Neighborhood Hits	166	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.074441 (rank : 191)
Query Neighborhood Hits	166	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.080629 (rank : 183)
Query Neighborhood Hits	166	Target Neighborhood Hits	350	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.081986 (rank : 182)
Query Neighborhood Hits	166	Target Neighborhood Hits	266	Shared Neighborhood Hits	31
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.054197 (rank : 247)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.053956 (rank : 250)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.058327 (rank : 231)
Query Neighborhood Hits	166	Target Neighborhood Hits	537	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.057711 (rank : 233)
Query Neighborhood Hits	166	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.060634 (rank : 224)
Query Neighborhood Hits	166	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.060327 (rank : 226)
Query Neighborhood Hits	166	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG2_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.240742 (rank : 125)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	62
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGC_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.213357 (rank : 127)
Query Neighborhood Hits	166	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.211500 (rank : 129)
Query Neighborhood Hits	166	Target Neighborhood Hits	344	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.287363 (rank : 110)
Query Neighborhood Hits	166	Target Neighborhood Hits	214	Shared Neighborhood Hits	61
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BCAR1_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.057510 (rank : 234)
Query Neighborhood Hits	166	Target Neighborhood Hits	438	Shared Neighborhood Hits	37
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CD2AP_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.104816 (rank : 151)
Query Neighborhood Hits	166	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.097932 (rank : 163)
Query Neighborhood Hits	166	Target Neighborhood Hits	336	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CENA1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.056098 (rank : 241)
Query Neighborhood Hits	166	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.053032 (rank : 253)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENB1_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.070673 (rank : 200)
Query Neighborhood Hits	166	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.078582 (rank : 187)
Query Neighborhood Hits	166	Target Neighborhood Hits	425	Shared Neighborhood Hits	20
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.074028 (rank : 194)
Query Neighborhood Hits	166	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CIP4_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.054631 (rank : 244)
Query Neighborhood Hits	166	Target Neighborhood Hits	374	Shared Neighborhood Hits	13
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.090182 (rank : 169)
Query Neighborhood Hits	166	Target Neighborhood Hits	313	Shared Neighborhood Hits	35
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.084229 (rank : 179)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	34
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.073051 (rank : 196)
Query Neighborhood Hits	166	Target Neighborhood Hits	308	Shared Neighborhood Hits	31
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.074140 (rank : 192)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	32
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.071304 (rank : 198)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.073574 (rank : 195)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.068623 (rank : 204)
Query Neighborhood Hits	166	Target Neighborhood Hits	592	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.076311 (rank : 189)
Query Neighborhood Hits	166	Target Neighborhood Hits	599	Shared Neighborhood Hits	41
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.074839 (rank : 190)
Query Neighborhood Hits	166	Target Neighborhood Hits	625	Shared Neighborhood Hits	38
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKD_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.054547 (rank : 246)
Query Neighborhood Hits	166	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.067429 (rank : 205)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	37
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

EFS_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.050751 (rank : 260)
Query Neighborhood Hits	166	Target Neighborhood Hits	389	Shared Neighborhood Hits	34
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FA13A_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.050675 (rank : 261)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FA13A_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.054039 (rank : 249)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

FYV1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.058942 (rank : 229)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.058509 (rank : 230)
Query Neighborhood Hits	166	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GRAP2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.086659 (rank : 176)
Query Neighborhood Hits	166	Target Neighborhood Hits	304	Shared Neighborhood Hits	34
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.084756 (rank : 178)
Query Neighborhood Hits	166	Target Neighborhood Hits	297	Shared Neighborhood Hits	33
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.110048 (rank : 144)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	37
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.106293 (rank : 150)
Query Neighborhood Hits	166	Target Neighborhood Hits	309	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.102182 (rank : 154)
Query Neighborhood Hits	166	Target Neighborhood Hits	310	Shared Neighborhood Hits	34
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.102151 (rank : 155)
Query Neighborhood Hits	166	Target Neighborhood Hits	312	Shared Neighborhood Hits	34
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.131046 (rank : 140)
Query Neighborhood Hits	166	Target Neighborhood Hits	131	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.087376 (rank : 175)
Query Neighborhood Hits	166	Target Neighborhood Hits	358	Shared Neighborhood Hits	31
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.087547 (rank : 174)
Query Neighborhood Hits	166	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.062570 (rank : 219)
Query Neighborhood Hits	166	Target Neighborhood Hits	517	Shared Neighborhood Hits	18
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.064395 (rank : 215)
Query Neighborhood Hits	166	Target Neighborhood Hits	589	Shared Neighborhood Hits	20
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

LBC_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.213289 (rank : 128)
Query Neighborhood Hits	166	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MYO1E_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.054554 (rank : 245)
Query Neighborhood Hits	166	Target Neighborhood Hits	293	Shared Neighborhood Hits	32
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.056493 (rank : 239)
Query Neighborhood Hits	166	Target Neighborhood Hits	275	Shared Neighborhood Hits	33
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.056920 (rank : 238)
Query Neighborhood Hits	166	Target Neighborhood Hits	262	Shared Neighborhood Hits	31
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.078642 (rank : 186)
Query Neighborhood Hits	166	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.080503 (rank : 184)
Query Neighborhood Hits	166	Target Neighborhood Hits	198	Shared Neighborhood Hits	30
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.098201 (rank : 161)
Query Neighborhood Hits	166	Target Neighborhood Hits	229	Shared Neighborhood Hits	36
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.093072 (rank : 166)
Query Neighborhood Hits	166	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.097945 (rank : 162)
Query Neighborhood Hits	166	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.098416 (rank : 160)
Query Neighborhood Hits	166	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.113422 (rank : 142)
Query Neighborhood Hits	166	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NPHP1_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.060756 (rank : 222)
Query Neighborhood Hits	166	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.068808 (rank : 202)
Query Neighborhood Hits	166	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.060414 (rank : 225)
Query Neighborhood Hits	166	Target Neighborhood Hits	466	Shared Neighborhood Hits	29
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.059043 (rank : 228)
Query Neighborhood Hits	166	Target Neighborhood Hits	467	Shared Neighborhood Hits	29
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.090913 (rank : 167)
Query Neighborhood Hits	166	Target Neighborhood Hits	451	Shared Neighborhood Hits	16
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.090603 (rank : 168)
Query Neighborhood Hits	166	Target Neighborhood Hits	401	Shared Neighborhood Hits	16
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PACN1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.050512 (rank : 262)
Query Neighborhood Hits	166	Target Neighborhood Hits	320	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.051252 (rank : 256)
Query Neighborhood Hits	166	Target Neighborhood Hits	283	Shared Neighborhood Hits	29
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.054070 (rank : 248)
Query Neighborhood Hits	166	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.051072 (rank : 258)
Query Neighborhood Hits	166	Target Neighborhood Hits	382	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PCTL_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.057432 (rank : 236)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.058188 (rank : 232)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.059726 (rank : 227)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PKHA1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.057376 (rank : 237)
Query Neighborhood Hits	166	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.051419 (rank : 255)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.055414 (rank : 243)
Query Neighborhood Hits	166	Target Neighborhood Hits	116	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.066309 (rank : 209)
Query Neighborhood Hits	166	Target Neighborhood Hits	283	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.070976 (rank : 199)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.055938 (rank : 242)
Query Neighborhood Hits	166	Target Neighborhood Hits	455	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.087746 (rank : 173)
Query Neighborhood Hits	166	Target Neighborhood Hits	556	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.087998 (rank : 172)
Query Neighborhood Hits	166	Target Neighborhood Hits	591	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.138855 (rank : 137)
Query Neighborhood Hits	166	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.140846 (rank : 135)
Query Neighborhood Hits	166	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.145321 (rank : 133)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.144968 (rank : 134)
Query Neighborhood Hits	166	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.062847 (rank : 218)
Query Neighborhood Hits	166	Target Neighborhood Hits	293	Shared Neighborhood Hits	40
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.063209 (rank : 217)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	39
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.057449 (rank : 235)
Query Neighborhood Hits	166	Target Neighborhood Hits	280	Shared Neighborhood Hits	29
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.076548 (rank : 188)
Query Neighborhood Hits	166	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.067390 (rank : 206)
Query Neighborhood Hits	166	Target Neighborhood Hits	377	Shared Neighborhood Hits	35
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RASF1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.050422 (rank : 263)
Query Neighborhood Hits	166	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RBNS5_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.065278 (rank : 214)
Query Neighborhood Hits	166	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.061655 (rank : 221)
Query Neighborhood Hits	166	Target Neighborhood Hits	266	Shared Neighborhood Hits	12
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RGNEF_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.201233 (rank : 130)
Query Neighborhood Hits	166	Target Neighborhood Hits	641	Shared Neighborhood Hits	69
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUFY2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.050865 (rank : 259)
Query Neighborhood Hits	166	Target Neighborhood Hits	820	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SH3G1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.066678 (rank : 208)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.063240 (rank : 216)
Query Neighborhood Hits	166	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.065881 (rank : 212)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	32
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.065903 (rank : 211)
Query Neighborhood Hits	166	Target Neighborhood Hits	319	Shared Neighborhood Hits	31
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.062241 (rank : 220)
Query Neighborhood Hits	166	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.060686 (rank : 223)
Query Neighborhood Hits	166	Target Neighborhood Hits	236	Shared Neighborhood Hits	29
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.107570 (rank : 145)
Query Neighborhood Hits	166	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.106448 (rank : 149)
Query Neighborhood Hits	166	Target Neighborhood Hits	332	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOS1_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.148295 (rank : 132)
Query Neighborhood Hits	166	Target Neighborhood Hits	274	Shared Neighborhood Hits	38
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.140463 (rank : 136)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.138814 (rank : 138)
Query Neighborhood Hits	166	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SRBS1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.107541 (rank : 146)
Query Neighborhood Hits	166	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.106882 (rank : 148)
Query Neighborhood Hits	166	Target Neighborhood Hits	409	Shared Neighborhood Hits	41
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.071728 (rank : 197)
Query Neighborhood Hits	166	Target Neighborhood Hits	269	Shared Neighborhood Hits	28
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.074085 (rank : 193)
Query Neighborhood Hits	166	Target Neighborhood Hits	292	Shared Neighborhood Hits	29
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.100373 (rank : 156)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	38
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.102380 (rank : 153)
Query Neighborhood Hits	166	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.095943 (rank : 165)
Query Neighborhood Hits	166	Target Neighborhood Hits	276	Shared Neighborhood Hits	39
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.099297 (rank : 159)
Query Neighborhood Hits	166	Target Neighborhood Hits	268	Shared Neighborhood Hits	39
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.068975 (rank : 201)
Query Neighborhood Hits	166	Target Neighborhood Hits	271	Shared Neighborhood Hits	31
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.068756 (rank : 203)
Query Neighborhood Hits	166	Target Neighborhood Hits	273	Shared Neighborhood Hits	29
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.065653 (rank : 213)
Query Neighborhood Hits	166	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.066156 (rank : 210)
Query Neighborhood Hits	166	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.285391 (rank : 112)
Query Neighborhood Hits	166	Target Neighborhood Hits	453	Shared Neighborhood Hits	83
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.288182 (rank : 109)
Query Neighborhood Hits	166	Target Neighborhood Hits	456	Shared Neighborhood Hits	85
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VINEX_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.104116 (rank : 152)
Query Neighborhood Hits	166	Target Neighborhood Hits	270	Shared Neighborhood Hits	40
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.107394 (rank : 147)
Query Neighborhood Hits	166	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.082540 (rank : 180)
Query Neighborhood Hits	166	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.084993 (rank : 177)
Query Neighborhood Hits	166	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.056396 (rank : 240)
Query Neighborhood Hits	166	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.053506 (rank : 252)
Query Neighborhood Hits	166	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.080329 (rank : 185)
Query Neighborhood Hits	166	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.082167 (rank : 181)
Query Neighborhood Hits	166	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.090064 (rank : 170)
Query Neighborhood Hits	166	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.052055 (rank : 254)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.051113 (rank : 257)
Query Neighborhood Hits	166	Target Neighborhood Hits	153	Shared Neighborhood Hits	13
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.088868 (rank : 171)
Query Neighborhood Hits	166	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ABR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	166
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.980929 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	134
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RHG09_HUMAN
NC score	0.768006 (rank : 3)	θ value	1.24688e-25 (rank : 7)
Query Neighborhood Hits	166	Target Neighborhood Hits	186	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
NC score	0.745987 (rank : 4)	θ value	3.87602e-27 (rank : 6)
Query Neighborhood Hits	166	Target Neighborhood Hits	190	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.743363 (rank : 5)	θ value	1.2049e-28 (rank : 5)
Query Neighborhood Hits	166	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RGAP1_HUMAN
NC score	0.738423 (rank : 6)	θ value	7.56453e-23 (rank : 13)
Query Neighborhood Hits	166	Target Neighborhood Hits	189	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_MOUSE
NC score	0.733942 (rank : 7)	θ value	1.09232e-21 (rank : 17)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GMIP_MOUSE
NC score	0.731693 (rank : 8)	θ value	1.13037e-18 (rank : 25)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	73
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GMIP_HUMAN
NC score	0.729183 (rank : 9)	θ value	4.58923e-20 (rank : 22)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_MOUSE
NC score	0.728177 (rank : 10)	θ value	1.33526e-19 (rank : 24)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	68
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCGAP_MOUSE
NC score	0.727479 (rank : 11)	θ value	8.93572e-24 (rank : 11)
Query Neighborhood Hits	166	Target Neighborhood Hits	409	Shared Neighborhood Hits	92
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CHIO_MOUSE
NC score	0.723419 (rank : 12)	θ value	1.62847e-25 (rank : 8)
Query Neighborhood Hits	166	Target Neighborhood Hits	130	Shared Neighborhood Hits	73
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GRLF1_HUMAN
NC score	0.719266 (rank : 13)	θ value	1.29031e-22 (rank : 14)
Query Neighborhood Hits	166	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

3BP1_HUMAN
NC score	0.717347 (rank : 14)	θ value	1.5242e-23 (rank : 12)
Query Neighborhood Hits	166	Target Neighborhood Hits	376	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG06_HUMAN
NC score	0.710661 (rank : 15)	θ value	4.44505e-15 (rank : 44)
Query Neighborhood Hits	166	Target Neighborhood Hits	114	Shared Neighborhood Hits	65
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.709969 (rank : 16)	θ value	5.25075e-16 (rank : 40)
Query Neighborhood Hits	166	Target Neighborhood Hits	105	Shared Neighborhood Hits	63
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CHIN_MOUSE
NC score	0.700094 (rank : 17)	θ value	6.38894e-30 (rank : 3)
Query Neighborhood Hits	166	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.698158 (rank : 18)	θ value	5.40856e-29 (rank : 4)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	74
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.694382 (rank : 19)	θ value	6.18819e-25 (rank : 9)
Query Neighborhood Hits	166	Target Neighborhood Hits	220	Shared Neighborhood Hits	74
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG18_HUMAN
NC score	0.693869 (rank : 20)	θ value	2.60593e-15 (rank : 43)
Query Neighborhood Hits	166	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG05_MOUSE
NC score	0.693232 (rank : 21)	θ value	8.36355e-22 (rank : 16)
Query Neighborhood Hits	166	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_MOUSE
NC score	0.692033 (rank : 22)	θ value	2.20605e-14 (rank : 49)
Query Neighborhood Hits	166	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG05_HUMAN
NC score	0.684868 (rank : 23)	θ value	2.06002e-20 (rank : 20)
Query Neighborhood Hits	166	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG01_HUMAN
NC score	0.682250 (rank : 24)	θ value	2.69671e-12 (rank : 59)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

OPHN1_HUMAN
NC score	0.679552 (rank : 25)	θ value	6.85773e-16 (rank : 41)
Query Neighborhood Hits	166	Target Neighborhood Hits	161	Shared Neighborhood Hits	63
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
NC score	0.678798 (rank : 26)	θ value	1.52774e-15 (rank : 42)
Query Neighborhood Hits	166	Target Neighborhood Hits	174	Shared Neighborhood Hits	63
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG04_HUMAN
NC score	0.677225 (rank : 27)	θ value	1.47631e-18 (rank : 28)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	80
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG08_MOUSE
NC score	0.673291 (rank : 28)	θ value	6.41864e-14 (rank : 52)
Query Neighborhood Hits	166	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG26_HUMAN
NC score	0.672942 (rank : 29)	θ value	1.13037e-18 (rank : 27)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG08_HUMAN
NC score	0.669138 (rank : 30)	θ value	6.41864e-14 (rank : 51)
Query Neighborhood Hits	166	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RBP1_MOUSE
NC score	0.663731 (rank : 31)	θ value	5.42112e-21 (rank : 18)
Query Neighborhood Hits	166	Target Neighborhood Hits	493	Shared Neighborhood Hits	63
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_MOUSE
NC score	0.658529 (rank : 32)	θ value	6.20254e-17 (rank : 37)
Query Neighborhood Hits	166	Target Neighborhood Hits	492	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SRGP2_HUMAN
NC score	0.657183 (rank : 33)	θ value	4.29542e-18 (rank : 30)
Query Neighborhood Hits	166	Target Neighborhood Hits	331	Shared Neighborhood Hits	80
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
NC score	0.650735 (rank : 34)	θ value	2.7842e-17 (rank : 34)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	80
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RBP1_HUMAN
NC score	0.648211 (rank : 35)	θ value	8.36355e-22 (rank : 15)
Query Neighborhood Hits	166	Target Neighborhood Hits	521	Shared Neighborhood Hits	63
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

TCGAP_HUMAN
NC score	0.647366 (rank : 36)	θ value	6.84181e-24 (rank : 10)
Query Neighborhood Hits	166	Target Neighborhood Hits	872	Shared Neighborhood Hits	94
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRGP1_HUMAN
NC score	0.647221 (rank : 37)	θ value	7.32683e-18 (rank : 31)
Query Neighborhood Hits	166	Target Neighborhood Hits	390	Shared Neighborhood Hits	80
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.640238 (rank : 38)	θ value	6.20254e-17 (rank : 36)
Query Neighborhood Hits	166	Target Neighborhood Hits	432	Shared Neighborhood Hits	79
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG25_HUMAN
NC score	0.634399 (rank : 39)	θ value	1.38178e-16 (rank : 38)
Query Neighborhood Hits	166	Target Neighborhood Hits	550	Shared Neighborhood Hits	72
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG07_MOUSE
NC score	0.618681 (rank : 40)	θ value	2.20605e-14 (rank : 48)
Query Neighborhood Hits	166	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.613060 (rank : 41)	θ value	1.86753e-13 (rank : 54)
Query Neighborhood Hits	166	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

TAGAP_HUMAN
NC score	0.598399 (rank : 42)	θ value	5.26297e-08 (rank : 78)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.596607 (rank : 43)	θ value	9.92553e-07 (rank : 86)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

STAR8_MOUSE
NC score	0.582397 (rank : 44)	θ value	4.59992e-12 (rank : 60)
Query Neighborhood Hits	166	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CEND2_HUMAN
NC score	0.580762 (rank : 45)	θ value	5.8054e-15 (rank : 45)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

STA13_HUMAN
NC score	0.576074 (rank : 46)	θ value	1.02475e-11 (rank : 63)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STAR8_HUMAN
NC score	0.575175 (rank : 47)	θ value	7.84624e-12 (rank : 61)
Query Neighborhood Hits	166	Target Neighborhood Hits	216	Shared Neighborhood Hits	64
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_MOUSE
NC score	0.566544 (rank : 48)	θ value	6.64225e-11 (rank : 68)
Query Neighborhood Hits	166	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CE005_HUMAN
NC score	0.558649 (rank : 49)	θ value	5.62301e-10 (rank : 71)
Query Neighborhood Hits	166	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.555577 (rank : 50)	θ value	7.34386e-10 (rank : 73)
Query Neighborhood Hits	166	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CEND3_MOUSE
NC score	0.545812 (rank : 51)	θ value	8.38298e-14 (rank : 53)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.536194 (rank : 52)	θ value	4.16044e-13 (rank : 57)
Query Neighborhood Hits	166	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND1_MOUSE
NC score	0.502393 (rank : 53)	θ value	2.20605e-14 (rank : 47)
Query Neighborhood Hits	166	Target Neighborhood Hits	260	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

K1688_MOUSE
NC score	0.486501 (rank : 54)	θ value	1.43324e-05 (rank : 100)
Query Neighborhood Hits	166	Target Neighborhood Hits	188	Shared Neighborhood Hits	60
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

CEND1_HUMAN
NC score	0.480966 (rank : 55)	θ value	4.16044e-13 (rank : 56)
Query Neighborhood Hits	166	Target Neighborhood Hits	284	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

K1688_HUMAN
NC score	0.478854 (rank : 56)	θ value	6.43352e-06 (rank : 95)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

ECT2_MOUSE
NC score	0.474651 (rank : 57)	θ value	2.7842e-17 (rank : 33)
Query Neighborhood Hits	166	Target Neighborhood Hits	98	Shared Neighborhood Hits	64
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.467633 (rank : 58)	θ value	1.24977e-17 (rank : 32)
Query Neighborhood Hits	166	Target Neighborhood Hits	98	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_MOUSE
NC score	0.461926 (rank : 59)	θ value	4.58923e-20 (rank : 21)
Query Neighborhood Hits	166	Target Neighborhood Hits	125	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.460761 (rank : 60)	θ value	7.0802e-21 (rank : 19)
Query Neighborhood Hits	166	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PREX1_HUMAN
NC score	0.442242 (rank : 61)	θ value	1.92812e-18 (rank : 29)
Query Neighborhood Hits	166	Target Neighborhood Hits	177	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FGD3_MOUSE
NC score	0.435938 (rank : 62)	θ value	1.02475e-11 (rank : 62)
Query Neighborhood Hits	166	Target Neighborhood Hits	257	Shared Neighborhood Hits	65
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.425838 (rank : 63)	θ value	3.18553e-13 (rank : 55)
Query Neighborhood Hits	166	Target Neighborhood Hits	151	Shared Neighborhood Hits	64
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.423977 (rank : 64)	θ value	2.88119e-14 (rank : 50)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	68
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
NC score	0.423757 (rank : 65)	θ value	5.62301e-10 (rank : 72)
Query Neighborhood Hits	166	Target Neighborhood Hits	249	Shared Neighborhood Hits	65
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_HUMAN
NC score	0.422194 (rank : 66)	θ value	9.90251e-15 (rank : 46)
Query Neighborhood Hits	166	Target Neighborhood Hits	219	Shared Neighborhood Hits	69
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_MOUSE
NC score	0.417675 (rank : 67)	θ value	1.33837e-11 (rank : 65)
Query Neighborhood Hits	166	Target Neighborhood Hits	163	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_HUMAN
NC score	0.410909 (rank : 68)	θ value	1.74796e-11 (rank : 66)
Query Neighborhood Hits	166	Target Neighborhood Hits	367	Shared Neighborhood Hits	67
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.409602 (rank : 69)	θ value	1.33837e-11 (rank : 64)
Query Neighborhood Hits	166	Target Neighborhood Hits	387	Shared Neighborhood Hits	69
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD6_HUMAN
NC score	0.403801 (rank : 70)	θ value	2.0648e-12 (rank : 58)
Query Neighborhood Hits	166	Target Neighborhood Hits	237	Shared Neighborhood Hits	63
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.401997 (rank : 71)	θ value	1.133e-10 (rank : 69)
Query Neighborhood Hits	166	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ARHG4_HUMAN
NC score	0.400735 (rank : 72)	θ value	2.21117e-06 (rank : 90)
Query Neighborhood Hits	166	Target Neighborhood Hits	242	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

P85A_HUMAN
NC score	0.398611 (rank : 73)	θ value	5.26297e-08 (rank : 76)
Query Neighborhood Hits	166	Target Neighborhood Hits	479	Shared Neighborhood Hits	71
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ARHG4_MOUSE
NC score	0.397978 (rank : 74)	θ value	1.69304e-06 (rank : 89)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHG1_HUMAN
NC score	0.396202 (rank : 75)	θ value	2.61198e-07 (rank : 84)
Query Neighborhood Hits	166	Target Neighborhood Hits	174	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG9_MOUSE
NC score	0.394885 (rank : 76)	θ value	8.97725e-08 (rank : 80)
Query Neighborhood Hits	166	Target Neighborhood Hits	234	Shared Neighborhood Hits	69
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.394799 (rank : 77)	θ value	8.97725e-08 (rank : 79)
Query Neighborhood Hits	166	Target Neighborhood Hits	235	Shared Neighborhood Hits	69
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

P85A_MOUSE
NC score	0.387956 (rank : 78)	θ value	5.26297e-08 (rank : 77)
Query Neighborhood Hits	166	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_MOUSE
NC score	0.381852 (rank : 79)	θ value	7.82807e-20 (rank : 23)
Query Neighborhood Hits	166	Target Neighborhood Hits	311	Shared Neighborhood Hits	74
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.376025 (rank : 80)	θ value	1.13037e-18 (rank : 26)
Query Neighborhood Hits	166	Target Neighborhood Hits	641	Shared Neighborhood Hits	80
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ARHG8_HUMAN
NC score	0.372490 (rank : 81)	θ value	1.38499e-08 (rank : 74)
Query Neighborhood Hits	166	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

GNRP_MOUSE
NC score	0.370394 (rank : 82)	θ value	4.74913e-17 (rank : 35)
Query Neighborhood Hits	166	Target Neighborhood Hits	191	Shared Neighborhood Hits	59
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG3_HUMAN
NC score	0.366353 (rank : 83)	θ value	5.81887e-07 (rank : 85)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

TIAM1_MOUSE
NC score	0.365810 (rank : 84)	θ value	1.99992e-07 (rank : 82)
Query Neighborhood Hits	166	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.364969 (rank : 85)	θ value	6.43352e-06 (rank : 97)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	70
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG3_MOUSE
NC score	0.364262 (rank : 86)	θ value	2.88788e-06 (rank : 91)
Query Neighborhood Hits	166	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

GNRP_HUMAN
NC score	0.349998 (rank : 87)	θ value	3.07829e-16 (rank : 39)
Query Neighborhood Hits	166	Target Neighborhood Hits	239	Shared Neighborhood Hits	59
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG5_HUMAN
NC score	0.347816 (rank : 88)	θ value	0.000121331 (rank : 107)
Query Neighborhood Hits	166	Target Neighborhood Hits	172	Shared Neighborhood Hits	66
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

MCF2_HUMAN
NC score	0.347114 (rank : 89)	θ value	6.43352e-06 (rank : 96)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	63
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG8_MOUSE
NC score	0.338338 (rank : 90)	θ value	8.40245e-06 (rank : 98)
Query Neighborhood Hits	166	Target Neighborhood Hits	79	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.337699 (rank : 91)	θ value	3.77169e-06 (rank : 92)
Query Neighborhood Hits	166	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_HUMAN
NC score	0.334225 (rank : 92)	θ value	9.29e-05 (rank : 106)
Query Neighborhood Hits	166	Target Neighborhood Hits	129	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD5_HUMAN
NC score	0.329672 (rank : 93)	θ value	1.29631e-06 (rank : 87)
Query Neighborhood Hits	166	Target Neighborhood Hits	235	Shared Neighborhood Hits	48
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

DNMBP_MOUSE
NC score	0.328279 (rank : 94)	θ value	3.77169e-06 (rank : 93)
Query Neighborhood Hits	166	Target Neighborhood Hits	435	Shared Neighborhood Hits	78
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NGEF_HUMAN
NC score	0.324301 (rank : 95)	θ value	0.47712 (rank : 125)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

DNMBP_HUMAN
NC score	0.320625 (rank : 96)	θ value	6.43352e-06 (rank : 94)
Query Neighborhood Hits	166	Target Neighborhood Hits	413	Shared Neighborhood Hits	77
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV3_MOUSE
NC score	0.319851 (rank : 97)	θ value	1.38499e-08 (rank : 75)
Query Neighborhood Hits	166	Target Neighborhood Hits	404	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.317823 (rank : 98)	θ value	1.99992e-07 (rank : 83)
Query Neighborhood Hits	166	Target Neighborhood Hits	398	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FGD5_MOUSE
NC score	0.315659 (rank : 99)	θ value	0.000270298 (rank : 109)
Query Neighborhood Hits	166	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

NGEF_MOUSE
NC score	0.314808 (rank : 100)	θ value	0.365318 (rank : 123)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	64
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MCF2L_MOUSE
NC score	0.313710 (rank : 101)	θ value	0.0113563 (rank : 116)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

VAV_MOUSE
NC score	0.301797 (rank : 102)	θ value	2.44474e-05 (rank : 103)
Query Neighborhood Hits	166	Target Neighborhood Hits	430	Shared Neighborhood Hits	86
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

FARP2_MOUSE
NC score	0.297544 (rank : 103)	θ value	2.52405e-10 (rank : 70)
Query Neighborhood Hits	166	Target Neighborhood Hits	209	Shared Neighborhood Hits	72
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG7_MOUSE
NC score	0.295866 (rank : 104)	θ value	0.21417 (rank : 121)
Query Neighborhood Hits	166	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

I5P2_HUMAN
NC score	0.294687 (rank : 105)	θ value	0.0113563 (rank : 115)
Query Neighborhood Hits	166	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

HAPIP_HUMAN
NC score	0.292966 (rank : 106)	θ value	4.1701e-05 (rank : 104)
Query Neighborhood Hits	166	Target Neighborhood Hits	350	Shared Neighborhood Hits	65
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG7_HUMAN
NC score	0.290048 (rank : 107)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	166	Target Neighborhood Hits	347	Shared Neighborhood Hits	71
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV_HUMAN
NC score	0.288723 (rank : 108)	θ value	0.000158464 (rank : 108)
Query Neighborhood Hits	166	Target Neighborhood Hits	452	Shared Neighborhood Hits	88
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_MOUSE
NC score	0.288182 (rank : 109)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	166	Target Neighborhood Hits	456	Shared Neighborhood Hits	85
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHGF_HUMAN
NC score	0.287363 (rank : 110)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	166	Target Neighborhood Hits	214	Shared Neighborhood Hits	61
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FARP2_HUMAN
NC score	0.286561 (rank : 111)	θ value	5.08577e-11 (rank : 67)
Query Neighborhood Hits	166	Target Neighborhood Hits	240	Shared Neighborhood Hits	66
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

VAV2_HUMAN
NC score	0.285391 (rank : 112)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	166	Target Neighborhood Hits	453	Shared Neighborhood Hits	83
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

OCRL_HUMAN
NC score	0.284636 (rank : 113)	θ value	0.00665767 (rank : 114)
Query Neighborhood Hits	166	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

PKHG4_HUMAN
NC score	0.273219 (rank : 114)	θ value	0.365318 (rank : 124)
Query Neighborhood Hits	166	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ITSN2_HUMAN
NC score	0.271719 (rank : 115)	θ value	1.87187e-05 (rank : 101)
Query Neighborhood Hits	166	Target Neighborhood Hits	1173	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG1_HUMAN
NC score	0.261058 (rank : 116)	θ value	0.365318 (rank : 122)
Query Neighborhood Hits	166	Target Neighborhood Hits	176	Shared Neighborhood Hits	56
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG6_HUMAN
NC score	0.260760 (rank : 117)	θ value	0.163984 (rank : 120)
Query Neighborhood Hits	166	Target Neighborhood Hits	376	Shared Neighborhood Hits	63
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHGB_HUMAN
NC score	0.258425 (rank : 118)	θ value	6.88961 (rank : 148)
Query Neighborhood Hits	166	Target Neighborhood Hits	375	Shared Neighborhood Hits	61
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ITSN1_HUMAN
NC score	0.257735 (rank : 119)	θ value	1.29631e-06 (rank : 88)
Query Neighborhood Hits	166	Target Neighborhood Hits	1757	Shared Neighborhood Hits	101
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.257028 (rank : 120)	θ value	2.44474e-05 (rank : 102)
Query Neighborhood Hits	166	Target Neighborhood Hits	1371	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
NC score	0.256873 (rank : 121)	θ value	1.53129e-07 (rank : 81)
Query Neighborhood Hits	166	Target Neighborhood Hits	1669	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FARP1_HUMAN
NC score	0.249598 (rank : 122)	θ value	0.00390308 (rank : 113)
Query Neighborhood Hits	166	Target Neighborhood Hits	241	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG6_MOUSE
NC score	0.248469 (rank : 123)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	166	Target Neighborhood Hits	394	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG1_MOUSE
NC score	0.243670 (rank : 124)	θ value	0.813845 (rank : 126)
Query Neighborhood Hits	166	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_MOUSE
NC score	0.240742 (rank : 125)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	62
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG2_HUMAN
NC score	0.219623 (rank : 126)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	166	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_HUMAN
NC score	0.213357 (rank : 127)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	166	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LBC_HUMAN
NC score	0.213289 (rank : 128)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	166	Target Neighborhood Hits	90	Shared Neighborhood Hits	49
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGC_MOUSE
NC score	0.211500 (rank : 129)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	166	Target Neighborhood Hits	344	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RGNEF_MOUSE
NC score	0.201233 (rank : 130)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	166	Target Neighborhood Hits	641	Shared Neighborhood Hits	69
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

P85B_HUMAN
NC score	0.157177 (rank : 131)	θ value	7.1131e-05 (rank : 105)
Query Neighborhood Hits	166	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SOS1_HUMAN
NC score	0.148295 (rank : 132)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	166	Target Neighborhood Hits	274	Shared Neighborhood Hits	38
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

PKHF2_HUMAN
NC score	0.145321 (rank : 133)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	166	Target Neighborhood Hits	75	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.144968 (rank : 134)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	166	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_MOUSE
NC score	0.140846 (rank : 135)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	166	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SOS1_MOUSE
NC score	0.140463 (rank : 136)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	166	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

PKHF1_HUMAN
NC score	0.138855 (rank : 137)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	166	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

SOS2_HUMAN
NC score	0.138814 (rank : 138)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	166	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

P85B_MOUSE
NC score	0.132020 (rank : 139)	θ value	0.000602161 (rank : 111)
Query Neighborhood Hits	166	Target Neighborhood Hits	519	Shared Neighborhood Hits	32
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GRP3_HUMAN
NC score	0.131046 (rank : 140)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	166	Target Neighborhood Hits	131	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

DUET_HUMAN
NC score	0.121300 (rank : 141)	θ value	1.43324e-05 (rank : 99)
Query Neighborhood Hits	166	Target Neighborhood Hits	1220	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NCK2_HUMAN
NC score	0.113422 (rank : 142)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	166	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

TRIO_HUMAN
NC score	0.111831 (rank : 143)	θ value	0.00102713 (rank : 112)
Query Neighborhood Hits	166	Target Neighborhood Hits	1580	Shared Neighborhood Hits	71
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

GRAP_HUMAN
NC score	0.110048 (rank : 144)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	37
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SH3K1_HUMAN
NC score	0.107570 (rank : 145)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	166	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SRBS1_HUMAN
NC score	0.107541 (rank : 146)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	166	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_MOUSE
NC score	0.107394 (rank : 147)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	166	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_MOUSE
NC score	0.106882 (rank : 148)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	166	Target Neighborhood Hits	409	Shared Neighborhood Hits	41
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3K1_MOUSE
NC score	0.106448 (rank : 149)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	166	Target Neighborhood Hits	332	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

GRAP_MOUSE
NC score	0.106293 (rank : 150)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	166	Target Neighborhood Hits	309	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CD2AP_HUMAN
NC score	0.104816 (rank : 151)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	166	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

VINEX_HUMAN
NC score	0.104116 (rank : 152)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	166	Target Neighborhood Hits	270	Shared Neighborhood Hits	40
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

STAC3_MOUSE
NC score	0.102380 (rank : 153)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	166	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRB2_HUMAN
NC score	0.102182 (rank : 154)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	166	Target Neighborhood Hits	310	Shared Neighborhood Hits	34
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.102151 (rank : 155)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	166	Target Neighborhood Hits	312	Shared Neighborhood Hits	34
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC3_HUMAN
NC score	0.100373 (rank : 156)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	166	Target Neighborhood Hits	228	Shared Neighborhood Hits	38
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

UN13A_HUMAN
NC score	0.099996 (rank : 157)	θ value	0.0736092 (rank : 117)
Query Neighborhood Hits	166	Target Neighborhood Hits	285	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
NC score	0.099451 (rank : 158)	θ value	0.0736092 (rank : 118)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	31
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

STAC_MOUSE
NC score	0.099297 (rank : 159)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	166	Target Neighborhood Hits	268	Shared Neighborhood Hits	39
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCK1_HUMAN
NC score	0.098416 (rank : 160)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	166	Target Neighborhood Hits	312	Shared Neighborhood Hits	37
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCF2_HUMAN
NC score	0.098201 (rank : 161)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	166	Target Neighborhood Hits	229	Shared Neighborhood Hits	36
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_MOUSE
NC score	0.097945 (rank : 162)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	166	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CD2AP_MOUSE
NC score	0.097932 (rank : 163)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	166	Target Neighborhood Hits	336	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

UN13B_MOUSE
NC score	0.096412 (rank : 164)	θ value	0.125558 (rank : 119)
Query Neighborhood Hits	166	Target Neighborhood Hits	210	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

STAC_HUMAN
NC score	0.095943 (rank : 165)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	166	Target Neighborhood Hits	276	Shared Neighborhood Hits	39
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_HUMAN
NC score	0.093072 (rank : 166)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	166	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

P55G_HUMAN
NC score	0.090913 (rank : 167)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	166	Target Neighborhood Hits	451	Shared Neighborhood Hits	16
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.090603 (rank : 168)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	166	Target Neighborhood Hits	401	Shared Neighborhood Hits	16
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CRKL_HUMAN
NC score	0.090182 (rank : 169)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	166	Target Neighborhood Hits	313	Shared Neighborhood Hits	35
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ZFY28_HUMAN
NC score	0.090064 (rank : 170)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	166	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.088868 (rank : 171)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	166	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PKHA6_MOUSE
NC score	0.087998 (rank : 172)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	166	Target Neighborhood Hits	591	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.087746 (rank : 173)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	166	Target Neighborhood Hits	556	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

HCLS1_MOUSE
NC score	0.087547 (rank : 174)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	166	Target Neighborhood Hits	329	Shared Neighborhood Hits	29
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.087376 (rank : 175)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	166	Target Neighborhood Hits	358	Shared Neighborhood Hits	31
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRAP2_HUMAN
NC score	0.086659 (rank : 176)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	166	Target Neighborhood Hits	304	Shared Neighborhood Hits	34
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ZFY16_MOUSE
NC score	0.084993 (rank : 177)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	166	Target Neighborhood Hits	108	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

GRAP2_MOUSE
NC score	0.084756 (rank : 178)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	166	Target Neighborhood Hits	297	Shared Neighborhood Hits	33
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CRKL_MOUSE
NC score	0.084229 (rank : 179)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	34
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ZFY16_HUMAN
NC score	0.082540 (rank : 180)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	166	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.082167 (rank : 181)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	166	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ABI2_MOUSE
NC score	0.081986 (rank : 182)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	166	Target Neighborhood Hits	266	Shared Neighborhood Hits	31
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.080629 (rank : 183)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	166	Target Neighborhood Hits	350	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NCF1_MOUSE
NC score	0.080503 (rank : 184)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	166	Target Neighborhood Hits	198	Shared Neighborhood Hits	30
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ZFY21_HUMAN
NC score	0.080329 (rank : 185)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	166	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

NCF1_HUMAN
NC score	0.078642 (rank : 186)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	166	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CENB2_HUMAN
NC score	0.078582 (rank : 187)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	166	Target Neighborhood Hits	425	Shared Neighborhood Hits	20
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

PPIP1_HUMAN
NC score	0.076548 (rank : 188)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	166	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

DDEF2_HUMAN
NC score	0.076311 (rank : 189)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	166	Target Neighborhood Hits	599	Shared Neighborhood Hits	41
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.074839 (rank : 190)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	166	Target Neighborhood Hits	625	Shared Neighborhood Hits	38
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ABI1_MOUSE
NC score	0.074441 (rank : 191)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	166	Target Neighborhood Hits	246	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CRK_MOUSE
NC score	0.074140 (rank : 192)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	32
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SRC8_MOUSE
NC score	0.074085 (rank : 193)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	166	Target Neighborhood Hits	292	Shared Neighborhood Hits	29
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CENB5_HUMAN
NC score	0.074028 (rank : 194)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	166	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

DAPP1_MOUSE
NC score	0.073574 (rank : 195)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	166	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CRK_HUMAN
NC score	0.073051 (rank : 196)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	166	Target Neighborhood Hits	308	Shared Neighborhood Hits	31
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SRC8_HUMAN
NC score	0.071728 (rank : 197)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	166	Target Neighborhood Hits	269	Shared Neighborhood Hits	28
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DAPP1_HUMAN
NC score	0.071304 (rank : 198)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA4_MOUSE
NC score	0.070976 (rank : 199)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	166	Target Neighborhood Hits	202	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CENB1_HUMAN
NC score	0.070673 (rank : 200)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	166	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

STAM1_HUMAN
NC score	0.068975 (rank : 201)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	166	Target Neighborhood Hits	271	Shared Neighborhood Hits	31
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NPHP1_MOUSE
NC score	0.068808 (rank : 202)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	166	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAM1_MOUSE
NC score	0.068756 (rank : 203)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	166	Target Neighborhood Hits	273	Shared Neighborhood Hits	29
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

DDEF1_MOUSE
NC score	0.068623 (rank : 204)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	166	Target Neighborhood Hits	592	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DGKH_HUMAN
NC score	0.067429 (rank : 205)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	166	Target Neighborhood Hits	255	Shared Neighborhood Hits	37
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PPIP1_MOUSE
NC score	0.067390 (rank : 206)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	166	Target Neighborhood Hits	377	Shared Neighborhood Hits	35
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI1_HUMAN
NC score	0.067066 (rank : 207)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	166	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G1_HUMAN
NC score	0.066678 (rank : 208)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	166	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PKHA4_HUMAN
NC score	0.066309 (rank : 209)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	166	Target Neighborhood Hits	283	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

STAM2_MOUSE
NC score	0.066156 (rank : 210)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	166	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G2_MOUSE
NC score	0.065903 (rank : 211)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	166	Target Neighborhood Hits	319	Shared Neighborhood Hits	31
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.065881 (rank : 212)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	166	Target Neighborhood Hits	324	Shared Neighborhood Hits	32
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

STAM2_HUMAN
NC score	0.065653 (rank : 213)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	166	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

RBNS5_HUMAN
NC score	0.065278 (rank : 214)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	166	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

HGS_MOUSE
NC score	0.064395 (rank : 215)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	166	Target Neighborhood Hits	589	Shared Neighborhood Hits	20
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

SH3G1_MOUSE
NC score	0.063240 (rank : 216)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	166	Target Neighborhood Hits	291	Shared Neighborhood Hits	29
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

PLCG1_MOUSE
NC score	0.063209 (rank : 217)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	166	Target Neighborhood Hits	314	Shared Neighborhood Hits	39
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.062847 (rank : 218)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	166	Target Neighborhood Hits	293	Shared Neighborhood Hits	40
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

HGS_HUMAN
NC score	0.062570 (rank : 219)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	166	Target Neighborhood Hits	517	Shared Neighborhood Hits	18
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

SH3G3_HUMAN
NC score	0.062241 (rank : 220)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	166	Target Neighborhood Hits	222	Shared Neighborhood Hits	29
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

RBNS5_MOUSE
NC score	0.061655 (rank : 221)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	166	Target Neighborhood Hits	266	Shared Neighborhood Hits	12
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

NPHP1_HUMAN
NC score	0.060756 (rank : 222)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	166	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SH3G3_MOUSE
NC score	0.060686 (rank : 223)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	166	Target Neighborhood Hits	236	Shared Neighborhood Hits	29
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ANM2_HUMAN
NC score	0.060634 (rank : 224)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	166	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

OSTF1_HUMAN
NC score	0.060414 (rank : 225)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	166	Target Neighborhood Hits	466	Shared Neighborhood Hits	29
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ANM2_MOUSE
NC score	0.060327 (rank : 226)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	166	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PDZD8_HUMAN
NC score	0.059726 (rank : 227)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	166	Target Neighborhood Hits	185	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

OSTF1_MOUSE
NC score	0.059043 (rank : 228)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	166	Target Neighborhood Hits	467	Shared Neighborhood Hits	29
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

FYV1_HUMAN
NC score	0.058942 (rank : 229)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	166	Target Neighborhood Hits	217	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.058509 (rank : 230)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	166	Target Neighborhood Hits	191	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

AHI1_HUMAN
NC score	0.058327 (rank : 231)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	166	Target Neighborhood Hits	537	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

PCTL_MOUSE
NC score	0.058188 (rank : 232)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

AHI1_MOUSE
NC score	0.057711 (rank : 233)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	166	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

BCAR1_MOUSE
NC score	0.057510 (rank : 234)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	166	Target Neighborhood Hits	438	Shared Neighborhood Hits	37
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PLCG2_HUMAN
NC score	0.057449 (rank : 235)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	166	Target Neighborhood Hits	280	Shared Neighborhood Hits	29
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PCTL_HUMAN
NC score	0.057432 (rank : 236)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	166	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PKHA1_HUMAN
NC score	0.057376 (rank : 237)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	166	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

MYO1F_MOUSE
NC score	0.056920 (rank : 238)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	166	Target Neighborhood Hits	262	Shared Neighborhood Hits	31
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.056493 (rank : 239)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	166	Target Neighborhood Hits	275	Shared Neighborhood Hits	33
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

ZFY19_HUMAN
NC score	0.056396 (rank : 240)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	166	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

CENA1_HUMAN
NC score	0.056098 (rank : 241)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	166	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

PKHA5_HUMAN
NC score	0.055938 (rank : 242)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	166	Target Neighborhood Hits	455	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA2_MOUSE
NC score	0.055414 (rank : 243)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	166	Target Neighborhood Hits	116	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CIP4_HUMAN
NC score	0.054631 (rank : 244)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	166	Target Neighborhood Hits	374	Shared Neighborhood Hits	13
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

MYO1E_HUMAN
NC score	0.054554 (rank : 245)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	166	Target Neighborhood Hits	293	Shared Neighborhood Hits	32
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

DGKD_HUMAN
NC score	0.054547 (rank : 246)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	166	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

ABI3_HUMAN
NC score	0.054197 (rank : 247)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PACN2_HUMAN
NC score	0.054070 (rank : 248)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	166	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

FA13A_MOUSE
NC score	0.054039 (rank : 249)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

ABI3_MOUSE
NC score	0.053956 (rank : 250)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	166	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

OBSCN_HUMAN
NC score	0.053799 (rank : 251)	θ value	0.000602161 (rank : 110)
Query Neighborhood Hits	166	Target Neighborhood Hits	1931	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ZFY19_MOUSE
NC score	0.053506 (rank : 252)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	166	Target Neighborhood Hits	143	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

CENA2_HUMAN
NC score	0.053032 (rank : 253)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	166	Target Neighborhood Hits	83	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

ZFYV1_HUMAN
NC score	0.052055 (rank : 254)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	166	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

PKHA1_MOUSE
NC score	0.051419 (rank : 255)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	166	Target Neighborhood Hits	120	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PACN1_MOUSE
NC score	0.051252 (rank : 256)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	166	Target Neighborhood Hits	283	Shared Neighborhood Hits	29
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ZFYV1_MOUSE
NC score	0.051113 (rank : 257)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	166	Target Neighborhood Hits	153	Shared Neighborhood Hits	13
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PACN2_MOUSE
NC score	0.051072 (rank : 258)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	166	Target Neighborhood Hits	382	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RUFY2_MOUSE
NC score	0.050865 (rank : 259)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	166	Target Neighborhood Hits	820	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

EFS_MOUSE
NC score	0.050751 (rank : 260)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	166	Target Neighborhood Hits	389	Shared Neighborhood Hits	34
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FA13A_HUMAN
NC score	0.050675 (rank : 261)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

PACN1_HUMAN
NC score	0.050512 (rank : 262)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	166	Target Neighborhood Hits	320	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RASF1_MOUSE
NC score	0.050422 (rank : 263)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	166	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

BSN_MOUSE
NC score	0.024929 (rank : 264)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	166	Target Neighborhood Hits	2057	Shared Neighborhood Hits	29
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

TAF4_HUMAN
NC score	0.024676 (rank : 265)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	166	Target Neighborhood Hits	687	Shared Neighborhood Hits	16
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

KPCA_HUMAN
NC score	0.021708 (rank : 266)	θ value	0.813845 (rank : 127)
Query Neighborhood Hits	166	Target Neighborhood Hits	1070	Shared Neighborhood Hits	35
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

BSN_HUMAN
NC score	0.020420 (rank : 267)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	166	Target Neighborhood Hits	1537	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

KPCB_MOUSE
NC score	0.020384 (rank : 268)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	166	Target Neighborhood Hits	1117	Shared Neighborhood Hits	33
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
NC score	0.020004 (rank : 269)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	166	Target Neighborhood Hits	1121	Shared Neighborhood Hits	33
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCA_MOUSE
NC score	0.019860 (rank : 270)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	166	Target Neighborhood Hits	1067	Shared Neighborhood Hits	35
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

DOC2G_MOUSE
NC score	0.018081 (rank : 271)	θ value	1.38821 (rank : 130)
Query Neighborhood Hits	166	Target Neighborhood Hits	125	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

PA24F_MOUSE
NC score	0.014220 (rank : 272)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	166	Target Neighborhood Hits	93	Shared Neighborhood Hits	14
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

JPH4_HUMAN
NC score	0.013683 (rank : 273)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	166	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH4_MOUSE
NC score	0.013417 (rank : 274)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

PA24F_HUMAN
NC score	0.013384 (rank : 275)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	166	Target Neighborhood Hits	78	Shared Neighborhood Hits	15
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

NXF2_HUMAN
NC score	0.012648 (rank : 276)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	166	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9GZY0, Q9BXU4, Q9NSS1, Q9NX66	Gene names	NXF2, TAPL2
Domain Architecture
Description	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2).

AMPD3_MOUSE
NC score	0.012614 (rank : 277)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	166	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	O08739, O88692	Gene names	Ampd3
Domain Architecture
Description	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (AMP deaminase H-type) (Heart-type AMPD).

AMPD3_HUMAN
NC score	0.012523 (rank : 278)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	166	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q01432	Gene names	AMPD3
Domain Architecture
Description	AMP deaminase 3 (EC 3.5.4.6) (AMP deaminase isoform E) (Erythrocyte AMP deaminase).

ECHB_MOUSE
NC score	0.011916 (rank : 279)	θ value	1.06291 (rank : 129)
Query Neighborhood Hits	166	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

GP158_MOUSE
NC score	0.011912 (rank : 280)	θ value	1.81305 (rank : 133)
Query Neighborhood Hits	166	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C419, Q8CHB0	Gene names	Gpr158, Kiaa1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

PA24E_MOUSE
NC score	0.011106 (rank : 281)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	166	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PRC1_HUMAN
NC score	0.010445 (rank : 282)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	166	Target Neighborhood Hits	328	Shared Neighborhood Hits	9
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

FA50A_HUMAN
NC score	0.010195 (rank : 283)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	166	Target Neighborhood Hits	264	Shared Neighborhood Hits	6
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

FA50A_MOUSE
NC score	0.010073 (rank : 284)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	166	Target Neighborhood Hits	293	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

JPH2_HUMAN
NC score	0.008969 (rank : 285)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	166	Target Neighborhood Hits	639	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

CCDC7_HUMAN
NC score	0.008577 (rank : 286)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	166	Target Neighborhood Hits	253	Shared Neighborhood Hits	4
SwissProt Accessions	Q96M83, Q8IVQ0, Q8NEQ0	Gene names	CCDC7
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 7.

AKAP2_HUMAN
NC score	0.008535 (rank : 287)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	166	Target Neighborhood Hits	507	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

CASZ1_HUMAN
NC score	0.007509 (rank : 288)	θ value	6.88961 (rank : 149)
Query Neighborhood Hits	166	Target Neighborhood Hits	473	Shared Neighborhood Hits	4
SwissProt Accessions	Q86V15, Q5T9S1, Q8WX49, Q8WX50, Q9BT16, Q9NXC6	Gene names	CASZ1, CST, ZNF693
Domain Architecture	No domain graphic available
Description	Castor homolog 1 zinc finger protein (Castor-related protein) (Zinc finger protein 693).

CSKI1_HUMAN
NC score	0.007112 (rank : 289)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	166	Target Neighborhood Hits	997	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SCG1_HUMAN
NC score	0.005175 (rank : 290)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	166	Target Neighborhood Hits	156	Shared Neighborhood Hits	4
SwissProt Accessions	P05060, Q9BQV6, Q9UJA6	Gene names	CHGB, SCG1
Domain Architecture
Description	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide].

NRDC_HUMAN
NC score	0.004116 (rank : 291)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	166	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

TBCD8_HUMAN
NC score	0.003612 (rank : 292)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	166	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	O95759, Q9UQ32	Gene names	TBC1D8, VRP
Domain Architecture
Description	TBC1 domain family member 8 (Vascular Rab-GAP/TBC-containing protein) (AD 3).

MMP15_MOUSE
NC score	0.001078 (rank : 293)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	166	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

FZD6_HUMAN
NC score	0.000508 (rank : 294)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	166	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

ABCA9_HUMAN
NC score	0.000472 (rank : 295)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	166	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

BCL3_MOUSE
NC score	-0.002821 (rank : 296)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	166	Target Neighborhood Hits	388	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

M4K5_HUMAN
NC score	-0.003836 (rank : 297)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	166	Target Neighborhood Hits	845	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

SUCR1_HUMAN
NC score	-0.004020 (rank : 298)	θ value	1.38821 (rank : 131)
Query Neighborhood Hits	166	Target Neighborhood Hits	696	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXA5, Q8TDQ8	Gene names	SUCNR1, GPR91
Domain Architecture
Description	Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like).

EVI1_MOUSE
NC score	-0.007972 (rank : 299)	θ value	6.88961 (rank : 150)
Query Neighborhood Hits	166	Target Neighborhood Hits	826	Shared Neighborhood Hits	6
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.