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Network neighborhood for query Sequence : NRDC_HUMAN

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NRDC_HUMAN
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NRDC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	60
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
θ value	0 (rank : 2)	NC score	0.986043 (rank : 2)
Query Neighborhood Hits	60	Target Neighborhood Hits	96	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

IDE_HUMAN
θ value	5.22361e-149 (rank : 3)	NC score	0.920153 (rank : 4)
Query Neighborhood Hits	60	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

IDE_MOUSE
θ value	5.22361e-149 (rank : 4)	NC score	0.920621 (rank : 3)
Query Neighborhood Hits	60	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

MPPA_MOUSE
θ value	4.1701e-05 (rank : 5)	NC score	0.273791 (rank : 5)
Query Neighborhood Hits	60	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DC61, Q3TF19	Gene names	Pmpca, Inpp5e
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_HUMAN
θ value	9.29e-05 (rank : 6)	NC score	0.262346 (rank : 6)
Query Neighborhood Hits	60	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O75439, O60416, Q96FV4	Gene names	PMPCB, MPPB
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

MPPB_MOUSE
θ value	0.000270298 (rank : 7)	NC score	0.246865 (rank : 8)
Query Neighborhood Hits	60	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CXT8	Gene names	Pmpcb
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_MOUSE
θ value	0.000270298 (rank : 8)	NC score	0.246734 (rank : 9)
Query Neighborhood Hits	60	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZ13, Q9CWL6	Gene names	Uqcrc1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

UQCR1_HUMAN
θ value	0.000461057 (rank : 9)	NC score	0.261086 (rank : 7)
Query Neighborhood Hits	60	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P31930, Q96DD2	Gene names	UQCRC1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

LEO1_MOUSE
θ value	0.00175202 (rank : 10)	NC score	0.102695 (rank : 13)
Query Neighborhood Hits	60	Target Neighborhood Hits	946	Shared Neighborhood Hits	26
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

NEST_HUMAN
θ value	0.00228821 (rank : 11)	NC score	0.033480 (rank : 38)
Query Neighborhood Hits	60	Target Neighborhood Hits	1305	Shared Neighborhood Hits	18
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

MPPA_HUMAN
θ value	0.00390308 (rank : 12)	NC score	0.241957 (rank : 10)
Query Neighborhood Hits	60	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

LEO1_HUMAN
θ value	0.00869519 (rank : 13)	NC score	0.096172 (rank : 14)
Query Neighborhood Hits	60	Target Neighborhood Hits	958	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

NEK1_MOUSE
θ value	0.0148317 (rank : 14)	NC score	0.014112 (rank : 58)
Query Neighborhood Hits	60	Target Neighborhood Hits	1311	Shared Neighborhood Hits	15
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

CC47_MOUSE
θ value	0.0193708 (rank : 15)	NC score	0.085370 (rank : 18)
Query Neighborhood Hits	60	Target Neighborhood Hits	245	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

SEC63_MOUSE
θ value	0.0193708 (rank : 16)	NC score	0.090106 (rank : 16)
Query Neighborhood Hits	60	Target Neighborhood Hits	601	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

TINAL_MOUSE
θ value	0.0431538 (rank : 17)	NC score	0.064217 (rank : 25)
Query Neighborhood Hits	60	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JR5, Q9EQT9	Gene names	Tinagl1, Arg1, Lcn7, Tinagl
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Androgen- regulated gene 1 protein) (Adrenocortical zonation factor 1) (AZ-1) (Tubulointerstitial nephritis antigen-related protein) (TARP).

PREP_MOUSE
θ value	0.0563607 (rank : 18)	NC score	0.128089 (rank : 12)
Query Neighborhood Hits	60	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K411, Q3THC4, Q3TJI1, Q3TPP0, Q3URQ8, Q4KUG2, Q4KUG3, Q6ZPX6, Q922N1, Q9CV63	Gene names	Pitrm1, Kiaa1104, Ntup1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (Pitrilysin metalloproteinase 1).

PREP_HUMAN
θ value	0.0961366 (rank : 19)	NC score	0.134074 (rank : 11)
Query Neighborhood Hits	60	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q5JRX3, O95204, Q2M2G6, Q4VBR1, Q5JRW7, Q7L5Z7, Q9BSI6, Q9BVJ5, Q9UPP8	Gene names	PITRM1, KIAA1104, MP1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (hPreP) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1).

NSBP1_MOUSE
θ value	0.163984 (rank : 20)	NC score	0.068110 (rank : 21)
Query Neighborhood Hits	60	Target Neighborhood Hits	681	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

SEC63_HUMAN
θ value	0.163984 (rank : 21)	NC score	0.078092 (rank : 20)
Query Neighborhood Hits	60	Target Neighborhood Hits	586	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

TINAL_HUMAN
θ value	0.163984 (rank : 22)	NC score	0.055768 (rank : 27)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZM7, Q8TEJ9, Q8WZ23, Q96GZ4, Q96JW3	Gene names	TINAGL1, GIS5, LCN7, OLRG2, TINAGL
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2).

IWS1_HUMAN
θ value	0.21417 (rank : 23)	NC score	0.058177 (rank : 26)
Query Neighborhood Hits	60	Target Neighborhood Hits	1241	Shared Neighborhood Hits	26
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MAP2_HUMAN
θ value	0.279714 (rank : 24)	NC score	0.033071 (rank : 39)
Query Neighborhood Hits	60	Target Neighborhood Hits	348	Shared Neighborhood Hits	7
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MDC1_MOUSE
θ value	0.279714 (rank : 25)	NC score	0.029452 (rank : 41)
Query Neighborhood Hits	60	Target Neighborhood Hits	998	Shared Neighborhood Hits	14
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

OPTN_HUMAN
θ value	0.365318 (rank : 26)	NC score	0.016911 (rank : 52)
Query Neighborhood Hits	60	Target Neighborhood Hits	827	Shared Neighborhood Hits	9
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

ERIC1_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.081411 (rank : 19)
Query Neighborhood Hits	60	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

IWS1_MOUSE
θ value	0.813845 (rank : 28)	NC score	0.066058 (rank : 23)
Query Neighborhood Hits	60	Target Neighborhood Hits	1258	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NC6IP_MOUSE
θ value	0.813845 (rank : 29)	NC score	0.040653 (rank : 31)
Query Neighborhood Hits	60	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

IASPP_HUMAN
θ value	1.06291 (rank : 30)	NC score	0.020166 (rank : 48)
Query Neighborhood Hits	60	Target Neighborhood Hits	688	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SH3G1_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.020410 (rank : 47)
Query Neighborhood Hits	60	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

APOB_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.026343 (rank : 45)
Query Neighborhood Hits	60	Target Neighborhood Hits	202	Shared Neighborhood Hits	2
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

CCD82_HUMAN
θ value	1.81305 (rank : 33)	NC score	0.049996 (rank : 29)
Query Neighborhood Hits	60	Target Neighborhood Hits	137	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N4S0, Q9H2Q5, Q9H5E3	Gene names	CCDC82
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 82.

SH3G1_HUMAN
θ value	1.81305 (rank : 34)	NC score	0.019054 (rank : 49)
Query Neighborhood Hits	60	Target Neighborhood Hits	307	Shared Neighborhood Hits	6
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

TCAL5_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.040611 (rank : 32)
Query Neighborhood Hits	60	Target Neighborhood Hits	806	Shared Neighborhood Hits	22
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TF2AY_MOUSE
θ value	2.36792 (rank : 36)	NC score	0.027417 (rank : 44)
Query Neighborhood Hits	60	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4I4, Q99PM2, Q9DAF4	Gene names	Gtf2a1lf, Alf
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

IASPP_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.015045 (rank : 57)
Query Neighborhood Hits	60	Target Neighborhood Hits	1024	Shared Neighborhood Hits	8
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TEX14_HUMAN
θ value	3.0926 (rank : 38)	NC score	0.015552 (rank : 56)
Query Neighborhood Hits	60	Target Neighborhood Hits	1103	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

HDGR3_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.030888 (rank : 40)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

RAG2_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.034670 (rank : 35)
Query Neighborhood Hits	60	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P21784	Gene names	Rag2, Rag-2
Domain Architecture
Description	V(D)J recombination-activating protein 2 (RAG-2).

RPGR_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.028312 (rank : 43)
Query Neighborhood Hits	60	Target Neighborhood Hits	281	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

CASC5_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.016985 (rank : 51)
Query Neighborhood Hits	60	Target Neighborhood Hits	376	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

MATR3_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.034465 (rank : 37)
Query Neighborhood Hits	60	Target Neighborhood Hits	321	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

TPA_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.002436 (rank : 65)
Query Neighborhood Hits	60	Target Neighborhood Hits	335	Shared Neighborhood Hits	2
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].

AGGF1_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.012104 (rank : 60)
Query Neighborhood Hits	60	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N302, O00581, Q53YS3, Q9BU84, Q9NW66	Gene names	AGGF1, VG5Q
Domain Architecture
Description	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (Vasculogenesis gene on 5q protein) (hVG5Q).

GPTC3_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.046812 (rank : 30)
Query Neighborhood Hits	60	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I76, Q5JYH2, Q8NDJ2, Q9H9Z3	Gene names	GPATC3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

MATR3_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.035868 (rank : 33)
Query Neighborhood Hits	60	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

SUCA_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.028375 (rank : 42)
Query Neighborhood Hits	60	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WUM5, Q8C2C3, Q9DBA3, Q9DCI8	Gene names	Suclg1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

VPS72_HUMAN
θ value	6.88961 (rank : 49)	NC score	0.035070 (rank : 34)
Query Neighborhood Hits	60	Target Neighborhood Hits	274	Shared Neighborhood Hits	15
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

VPS72_MOUSE
θ value	6.88961 (rank : 50)	NC score	0.034591 (rank : 36)
Query Neighborhood Hits	60	Target Neighborhood Hits	286	Shared Neighborhood Hits	14
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

ABR_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.004116 (rank : 64)
Query Neighborhood Hits	60	Target Neighborhood Hits	166	Shared Neighborhood Hits	2
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

DIAP1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.004505 (rank : 63)
Query Neighborhood Hits	60	Target Neighborhood Hits	784	Shared Neighborhood Hits	7
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

MEPE_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.018003 (rank : 50)
Query Neighborhood Hits	60	Target Neighborhood Hits	105	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

SEPT8_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.009592 (rank : 62)
Query Neighborhood Hits	60	Target Neighborhood Hits	290	Shared Neighborhood Hits	7
SwissProt Accessions	Q92599, Q8IX36, Q8IX37, Q9BVB3	Gene names	SEPT8, KIAA0202
Domain Architecture
Description	Septin-8.

STAG2_HUMAN
θ value	8.99809 (rank : 55)	NC score	0.015693 (rank : 55)
Query Neighborhood Hits	60	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N3U4, O00540, Q5JTI6, Q9H1N8	Gene names	STAG2, SA2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STAG2_MOUSE
θ value	8.99809 (rank : 56)	NC score	0.015713 (rank : 54)
Query Neighborhood Hits	60	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	O35638, Q6NZN7	Gene names	Stag2, Sa2, Sap2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STX6_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.010853 (rank : 61)
Query Neighborhood Hits	60	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O43752, Q5VY08, Q6FH83	Gene names	STX6
Domain Architecture
Description	Syntaxin-6.

SUCA_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.025279 (rank : 46)
Query Neighborhood Hits	60	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P53597, Q9BWB0, Q9UNP6	Gene names	SUCLG1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

TGON2_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.016818 (rank : 53)
Query Neighborhood Hits	60	Target Neighborhood Hits	1037	Shared Neighborhood Hits	17
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TTLL1_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.013226 (rank : 59)
Query Neighborhood Hits	60	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O95922, Q9BR27, Q9NRS9, Q9UMU0	Gene names	TTLL1, C22orf7
Domain Architecture
Description	Probable tubulin polyglutamylase (EC 6.-.-.-) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1).

PTMA_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.067356 (rank : 22)
Query Neighborhood Hits	60	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

PTMA_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.065809 (rank : 24)
Query Neighborhood Hits	60	Target Neighborhood Hits	73	Shared Neighborhood Hits	14
SwissProt Accessions	P26350, Q3UQV6	Gene names	Ptma
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha].

PTMS_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.053159 (rank : 28)
Query Neighborhood Hits	60	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D0J8	Gene names	Ptms
Domain Architecture	No domain graphic available
Description	Parathymosin.

UQCR2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.089733 (rank : 17)
Query Neighborhood Hits	60	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P22695, Q9BQ05	Gene names	UQCRC2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

UQCR2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.091385 (rank : 15)
Query Neighborhood Hits	60	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DB77	Gene names	Uqcrc2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

Hits sorted by NC score

NRDC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	60
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
NC score	0.986043 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	60	Target Neighborhood Hits	96	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

IDE_MOUSE
NC score	0.920621 (rank : 3)	θ value	5.22361e-149 (rank : 4)
Query Neighborhood Hits	60	Target Neighborhood Hits	22	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

IDE_HUMAN
NC score	0.920153 (rank : 4)	θ value	5.22361e-149 (rank : 3)
Query Neighborhood Hits	60	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

MPPA_MOUSE
NC score	0.273791 (rank : 5)	θ value	4.1701e-05 (rank : 5)
Query Neighborhood Hits	60	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DC61, Q3TF19	Gene names	Pmpca, Inpp5e
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_HUMAN
NC score	0.262346 (rank : 6)	θ value	9.29e-05 (rank : 6)
Query Neighborhood Hits	60	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O75439, O60416, Q96FV4	Gene names	PMPCB, MPPB
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_HUMAN
NC score	0.261086 (rank : 7)	θ value	0.000461057 (rank : 9)
Query Neighborhood Hits	60	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P31930, Q96DD2	Gene names	UQCRC1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

MPPB_MOUSE
NC score	0.246865 (rank : 8)	θ value	0.000270298 (rank : 7)
Query Neighborhood Hits	60	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CXT8	Gene names	Pmpcb
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_MOUSE
NC score	0.246734 (rank : 9)	θ value	0.000270298 (rank : 8)
Query Neighborhood Hits	60	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZ13, Q9CWL6	Gene names	Uqcrc1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

MPPA_HUMAN
NC score	0.241957 (rank : 10)	θ value	0.00390308 (rank : 12)
Query Neighborhood Hits	60	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

PREP_HUMAN
NC score	0.134074 (rank : 11)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	60	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q5JRX3, O95204, Q2M2G6, Q4VBR1, Q5JRW7, Q7L5Z7, Q9BSI6, Q9BVJ5, Q9UPP8	Gene names	PITRM1, KIAA1104, MP1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (hPreP) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1).

PREP_MOUSE
NC score	0.128089 (rank : 12)	θ value	0.0563607 (rank : 18)
Query Neighborhood Hits	60	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K411, Q3THC4, Q3TJI1, Q3TPP0, Q3URQ8, Q4KUG2, Q4KUG3, Q6ZPX6, Q922N1, Q9CV63	Gene names	Pitrm1, Kiaa1104, Ntup1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (Pitrilysin metalloproteinase 1).

LEO1_MOUSE
NC score	0.102695 (rank : 13)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	60	Target Neighborhood Hits	946	Shared Neighborhood Hits	26
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LEO1_HUMAN
NC score	0.096172 (rank : 14)	θ value	0.00869519 (rank : 13)
Query Neighborhood Hits	60	Target Neighborhood Hits	958	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

UQCR2_MOUSE
NC score	0.091385 (rank : 15)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	60	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DB77	Gene names	Uqcrc2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

SEC63_MOUSE
NC score	0.090106 (rank : 16)	θ value	0.0193708 (rank : 16)
Query Neighborhood Hits	60	Target Neighborhood Hits	601	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

UQCR2_HUMAN
NC score	0.089733 (rank : 17)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	60	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P22695, Q9BQ05	Gene names	UQCRC2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

CC47_MOUSE
NC score	0.085370 (rank : 18)	θ value	0.0193708 (rank : 15)
Query Neighborhood Hits	60	Target Neighborhood Hits	245	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

ERIC1_HUMAN
NC score	0.081411 (rank : 19)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	60	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

SEC63_HUMAN
NC score	0.078092 (rank : 20)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	60	Target Neighborhood Hits	586	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

NSBP1_MOUSE
NC score	0.068110 (rank : 21)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	60	Target Neighborhood Hits	681	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

PTMA_HUMAN
NC score	0.067356 (rank : 22)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	60	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

IWS1_MOUSE
NC score	0.066058 (rank : 23)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	60	Target Neighborhood Hits	1258	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PTMA_MOUSE
NC score	0.065809 (rank : 24)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	60	Target Neighborhood Hits	73	Shared Neighborhood Hits	14
SwissProt Accessions	P26350, Q3UQV6	Gene names	Ptma
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha].

TINAL_MOUSE
NC score	0.064217 (rank : 25)	θ value	0.0431538 (rank : 17)
Query Neighborhood Hits	60	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q99JR5, Q9EQT9	Gene names	Tinagl1, Arg1, Lcn7, Tinagl
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Androgen- regulated gene 1 protein) (Adrenocortical zonation factor 1) (AZ-1) (Tubulointerstitial nephritis antigen-related protein) (TARP).

IWS1_HUMAN
NC score	0.058177 (rank : 26)	θ value	0.21417 (rank : 23)
Query Neighborhood Hits	60	Target Neighborhood Hits	1241	Shared Neighborhood Hits	26
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TINAL_HUMAN
NC score	0.055768 (rank : 27)	θ value	0.163984 (rank : 22)
Query Neighborhood Hits	60	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZM7, Q8TEJ9, Q8WZ23, Q96GZ4, Q96JW3	Gene names	TINAGL1, GIS5, LCN7, OLRG2, TINAGL
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2).

PTMS_MOUSE
NC score	0.053159 (rank : 28)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	60	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D0J8	Gene names	Ptms
Domain Architecture	No domain graphic available
Description	Parathymosin.

CCD82_HUMAN
NC score	0.049996 (rank : 29)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	60	Target Neighborhood Hits	137	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N4S0, Q9H2Q5, Q9H5E3	Gene names	CCDC82
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 82.

GPTC3_HUMAN
NC score	0.046812 (rank : 30)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	60	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I76, Q5JYH2, Q8NDJ2, Q9H9Z3	Gene names	GPATC3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

NC6IP_MOUSE
NC score	0.040653 (rank : 31)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	60	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

TCAL5_HUMAN
NC score	0.040611 (rank : 32)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	60	Target Neighborhood Hits	806	Shared Neighborhood Hits	22
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

MATR3_HUMAN
NC score	0.035868 (rank : 33)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	60	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

VPS72_HUMAN
NC score	0.035070 (rank : 34)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	60	Target Neighborhood Hits	274	Shared Neighborhood Hits	15
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

RAG2_MOUSE
NC score	0.034670 (rank : 35)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	60	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P21784	Gene names	Rag2, Rag-2
Domain Architecture
Description	V(D)J recombination-activating protein 2 (RAG-2).

VPS72_MOUSE
NC score	0.034591 (rank : 36)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	60	Target Neighborhood Hits	286	Shared Neighborhood Hits	14
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

MATR3_MOUSE
NC score	0.034465 (rank : 37)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	60	Target Neighborhood Hits	321	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

NEST_HUMAN
NC score	0.033480 (rank : 38)	θ value	0.00228821 (rank : 11)
Query Neighborhood Hits	60	Target Neighborhood Hits	1305	Shared Neighborhood Hits	18
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

MAP2_HUMAN
NC score	0.033071 (rank : 39)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	60	Target Neighborhood Hits	348	Shared Neighborhood Hits	7
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

HDGR3_HUMAN
NC score	0.030888 (rank : 40)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	60	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y3E1	Gene names	HDGFRP3, HDGF2
Domain Architecture	No domain graphic available
Description	Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma- derived growth factor 2).

MDC1_MOUSE
NC score	0.029452 (rank : 41)	θ value	0.279714 (rank : 25)
Query Neighborhood Hits	60	Target Neighborhood Hits	998	Shared Neighborhood Hits	14
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

SUCA_MOUSE
NC score	0.028375 (rank : 42)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	60	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WUM5, Q8C2C3, Q9DBA3, Q9DCI8	Gene names	Suclg1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

RPGR_MOUSE
NC score	0.028312 (rank : 43)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	60	Target Neighborhood Hits	281	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

TF2AY_MOUSE
NC score	0.027417 (rank : 44)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	60	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4I4, Q99PM2, Q9DAF4	Gene names	Gtf2a1lf, Alf
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

APOB_HUMAN
NC score	0.026343 (rank : 45)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	60	Target Neighborhood Hits	202	Shared Neighborhood Hits	2
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

SUCA_HUMAN
NC score	0.025279 (rank : 46)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	60	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P53597, Q9BWB0, Q9UNP6	Gene names	SUCLG1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

SH3G1_MOUSE
NC score	0.020410 (rank : 47)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	60	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

IASPP_HUMAN
NC score	0.020166 (rank : 48)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	60	Target Neighborhood Hits	688	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SH3G1_HUMAN
NC score	0.019054 (rank : 49)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	60	Target Neighborhood Hits	307	Shared Neighborhood Hits	6
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

MEPE_HUMAN
NC score	0.018003 (rank : 50)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	60	Target Neighborhood Hits	105	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

CASC5_HUMAN
NC score	0.016985 (rank : 51)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	60	Target Neighborhood Hits	376	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

OPTN_HUMAN
NC score	0.016911 (rank : 52)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	60	Target Neighborhood Hits	827	Shared Neighborhood Hits	9
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

TGON2_HUMAN
NC score	0.016818 (rank : 53)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	60	Target Neighborhood Hits	1037	Shared Neighborhood Hits	17
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

STAG2_MOUSE
NC score	0.015713 (rank : 54)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	60	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	O35638, Q6NZN7	Gene names	Stag2, Sa2, Sap2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

STAG2_HUMAN
NC score	0.015693 (rank : 55)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	60	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N3U4, O00540, Q5JTI6, Q9H1N8	Gene names	STAG2, SA2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

TEX14_HUMAN
NC score	0.015552 (rank : 56)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	60	Target Neighborhood Hits	1103	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

IASPP_MOUSE
NC score	0.015045 (rank : 57)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	60	Target Neighborhood Hits	1024	Shared Neighborhood Hits	8
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NEK1_MOUSE
NC score	0.014112 (rank : 58)	θ value	0.0148317 (rank : 14)
Query Neighborhood Hits	60	Target Neighborhood Hits	1311	Shared Neighborhood Hits	15
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

TTLL1_HUMAN
NC score	0.013226 (rank : 59)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	60	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	O95922, Q9BR27, Q9NRS9, Q9UMU0	Gene names	TTLL1, C22orf7
Domain Architecture
Description	Probable tubulin polyglutamylase (EC 6.-.-.-) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1).

AGGF1_HUMAN
NC score	0.012104 (rank : 60)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	60	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N302, O00581, Q53YS3, Q9BU84, Q9NW66	Gene names	AGGF1, VG5Q
Domain Architecture
Description	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (Vasculogenesis gene on 5q protein) (hVG5Q).

STX6_HUMAN
NC score	0.010853 (rank : 61)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	60	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O43752, Q5VY08, Q6FH83	Gene names	STX6
Domain Architecture
Description	Syntaxin-6.

SEPT8_HUMAN
NC score	0.009592 (rank : 62)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	60	Target Neighborhood Hits	290	Shared Neighborhood Hits	7
SwissProt Accessions	Q92599, Q8IX36, Q8IX37, Q9BVB3	Gene names	SEPT8, KIAA0202
Domain Architecture
Description	Septin-8.

DIAP1_HUMAN
NC score	0.004505 (rank : 63)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	60	Target Neighborhood Hits	784	Shared Neighborhood Hits	7
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

ABR_HUMAN
NC score	0.004116 (rank : 64)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	60	Target Neighborhood Hits	166	Shared Neighborhood Hits	2
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

TPA_MOUSE
NC score	0.002436 (rank : 65)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	60	Target Neighborhood Hits	335	Shared Neighborhood Hits	2
SwissProt Accessions	P11214, Q91VP2	Gene names	Plat
Domain Architecture
Description	Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B].