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Network neighborhood for query Sequence : IDE_HUMAN

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IDE_HUMAN
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IDE_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

IDE_MOUSE
θ value	0 (rank : 2)	NC score	0.998956 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	22	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

NRDC_MOUSE
θ value	3.27187e-151 (rank : 3)	NC score	0.910588 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_HUMAN
θ value	5.22361e-149 (rank : 4)	NC score	0.920153 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

MPPB_HUMAN
θ value	0.00035302 (rank : 5)	NC score	0.244850 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O75439, O60416, Q96FV4	Gene names	PMPCB, MPPB
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_HUMAN
θ value	0.000602161 (rank : 6)	NC score	0.244784 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P31930, Q96DD2	Gene names	UQCRC1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

MPPA_MOUSE
θ value	0.000786445 (rank : 7)	NC score	0.254461 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DC61, Q3TF19	Gene names	Pmpca, Inpp5e
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPA_HUMAN
θ value	0.00665767 (rank : 8)	NC score	0.227046 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_MOUSE
θ value	0.00665767 (rank : 9)	NC score	0.226071 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CXT8	Gene names	Pmpcb
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_MOUSE
θ value	0.0252991 (rank : 10)	NC score	0.221307 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZ13, Q9CWL6	Gene names	Uqcrc1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

PREP_HUMAN
θ value	0.0330416 (rank : 11)	NC score	0.138061 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q5JRX3, O95204, Q2M2G6, Q4VBR1, Q5JRW7, Q7L5Z7, Q9BSI6, Q9BVJ5, Q9UPP8	Gene names	PITRM1, KIAA1104, MP1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (hPreP) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1).

PREP_MOUSE
θ value	0.21417 (rank : 12)	NC score	0.126038 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K411, Q3THC4, Q3TJI1, Q3TPP0, Q3URQ8, Q4KUG2, Q4KUG3, Q6ZPX6, Q922N1, Q9CV63	Gene names	Pitrm1, Kiaa1104, Ntup1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (Pitrilysin metalloproteinase 1).

ANPRA_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.008084 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	612	Shared Neighborhood Hits	3
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	2.36792 (rank : 14)	NC score	0.008051 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	600	Shared Neighborhood Hits	3
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

PCDGA_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.005717 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	160	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5H3, Q9Y5E0	Gene names	PCDHGA10
Domain Architecture
Description	Protocadherin gamma A10 precursor (PCDH-gamma-A10).

ANGL7_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.010881 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1Q3	Gene names	Angptl7
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 7 precursor (Angiopoietin-like 7).

DEN2D_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.012451 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H6A0, Q5T5V6, Q9BSU0	Gene names	DENND2D
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

ZN263_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.000005 (rank : 25)
Query Neighborhood Hits	23	Target Neighborhood Hits	795	Shared Neighborhood Hits	2
SwissProt Accessions	O14978, O43387, Q96H95	Gene names	ZNF263, FPM315
Domain Architecture
Description	Zinc finger protein 263 (Zinc finger protein FPM315).

ANGL7_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.009702 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	O43827, Q4ZGK4	Gene names	ANGPTL7, CDT6
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 7 precursor (Angiopoietin-like 7) (Angiopoietin-like factor) (Cornea-derived transcript 6 protein).

TTK_HUMAN
θ value	5.27518 (rank : 20)	NC score	0.002673 (rank : 24)
Query Neighborhood Hits	23	Target Neighborhood Hits	816	Shared Neighborhood Hits	4
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTC16_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.016640 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	417	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

RAB30_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.003715 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q15771, Q6FGK1, Q96CI8	Gene names	RAB30
Domain Architecture
Description	Ras-related protein Rab-30.

RAB30_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.003715 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q923S9, Q3UQR3, Q9D3Q6	Gene names	Rab30, Rsb30
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-30.

UQCR2_HUMAN
θ value	θ > 10 (rank : 24)	NC score	0.077703 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P22695, Q9BQ05	Gene names	UQCRC2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

UQCR2_MOUSE
θ value	θ > 10 (rank : 25)	NC score	0.079138 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DB77	Gene names	Uqcrc2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

Hits sorted by NC score

IDE_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

IDE_MOUSE
NC score	0.998956 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	22	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

NRDC_HUMAN
NC score	0.920153 (rank : 3)	θ value	5.22361e-149 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
NC score	0.910588 (rank : 4)	θ value	3.27187e-151 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

MPPA_MOUSE
NC score	0.254461 (rank : 5)	θ value	0.000786445 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DC61, Q3TF19	Gene names	Pmpca, Inpp5e
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_HUMAN
NC score	0.244850 (rank : 6)	θ value	0.00035302 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	O75439, O60416, Q96FV4	Gene names	PMPCB, MPPB
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_HUMAN
NC score	0.244784 (rank : 7)	θ value	0.000602161 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P31930, Q96DD2	Gene names	UQCRC1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

MPPA_HUMAN
NC score	0.227046 (rank : 8)	θ value	0.00665767 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_MOUSE
NC score	0.226071 (rank : 9)	θ value	0.00665767 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CXT8	Gene names	Pmpcb
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_MOUSE
NC score	0.221307 (rank : 10)	θ value	0.0252991 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CZ13, Q9CWL6	Gene names	Uqcrc1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

PREP_HUMAN
NC score	0.138061 (rank : 11)	θ value	0.0330416 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q5JRX3, O95204, Q2M2G6, Q4VBR1, Q5JRW7, Q7L5Z7, Q9BSI6, Q9BVJ5, Q9UPP8	Gene names	PITRM1, KIAA1104, MP1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (hPreP) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1).

PREP_MOUSE
NC score	0.126038 (rank : 12)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K411, Q3THC4, Q3TJI1, Q3TPP0, Q3URQ8, Q4KUG2, Q4KUG3, Q6ZPX6, Q922N1, Q9CV63	Gene names	Pitrm1, Kiaa1104, Ntup1
Domain Architecture	No domain graphic available
Description	Presequence protease, mitochondrial precursor (EC 3.4.24.-) (Pitrilysin metalloproteinase 1).

UQCR2_MOUSE
NC score	0.079138 (rank : 13)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	23	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DB77	Gene names	Uqcrc2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

UQCR2_HUMAN
NC score	0.077703 (rank : 14)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	23	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	P22695, Q9BQ05	Gene names	UQCRC2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

TTC16_HUMAN
NC score	0.016640 (rank : 15)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	417	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

DEN2D_HUMAN
NC score	0.012451 (rank : 16)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H6A0, Q5T5V6, Q9BSU0	Gene names	DENND2D
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

ANGL7_MOUSE
NC score	0.010881 (rank : 17)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R1Q3	Gene names	Angptl7
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 7 precursor (Angiopoietin-like 7).

ANGL7_HUMAN
NC score	0.009702 (rank : 18)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	O43827, Q4ZGK4	Gene names	ANGPTL7, CDT6
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 7 precursor (Angiopoietin-like 7) (Angiopoietin-like factor) (Cornea-derived transcript 6 protein).

ANPRA_HUMAN
NC score	0.008084 (rank : 19)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	612	Shared Neighborhood Hits	3
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.008051 (rank : 20)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	600	Shared Neighborhood Hits	3
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

PCDGA_HUMAN
NC score	0.005717 (rank : 21)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	160	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5H3, Q9Y5E0	Gene names	PCDHGA10
Domain Architecture
Description	Protocadherin gamma A10 precursor (PCDH-gamma-A10).

RAB30_HUMAN
NC score	0.003715 (rank : 22)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q15771, Q6FGK1, Q96CI8	Gene names	RAB30
Domain Architecture
Description	Ras-related protein Rab-30.

RAB30_MOUSE
NC score	0.003715 (rank : 23)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q923S9, Q3UQR3, Q9D3Q6	Gene names	Rab30, Rsb30
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-30.

TTK_HUMAN
NC score	0.002673 (rank : 24)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	816	Shared Neighborhood Hits	4
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

ZN263_HUMAN
NC score	0.000005 (rank : 25)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	795	Shared Neighborhood Hits	2
SwissProt Accessions	O14978, O43387, Q96H95	Gene names	ZNF263, FPM315
Domain Architecture
Description	Zinc finger protein 263 (Zinc finger protein FPM315).