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Network neighborhood for query Sequence : MPPA_HUMAN

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MPPA_HUMAN
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MPPA_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPA_MOUSE
θ value	0 (rank : 2)	NC score	0.998686 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DC61, Q3TF19	Gene names	Pmpca, Inpp5e
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_HUMAN
θ value	1.788e-48 (rank : 3)	NC score	0.875982 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	O75439, O60416, Q96FV4	Gene names	PMPCB, MPPB
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

MPPB_MOUSE
θ value	2.3352e-48 (rank : 4)	NC score	0.876799 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CXT8	Gene names	Pmpcb
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_MOUSE
θ value	6.58091e-43 (rank : 5)	NC score	0.864338 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CZ13, Q9CWL6	Gene names	Uqcrc1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

UQCR1_HUMAN
θ value	8.04462e-41 (rank : 6)	NC score	0.858043 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P31930, Q96DD2	Gene names	UQCRC1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

UQCR2_MOUSE
θ value	3.74554e-30 (rank : 7)	NC score	0.805654 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DB77	Gene names	Uqcrc2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

UQCR2_HUMAN
θ value	1.73987e-27 (rank : 8)	NC score	0.799037 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	P22695, Q9BQ05	Gene names	UQCRC2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

IDE_MOUSE
θ value	0.00228821 (rank : 9)	NC score	0.234860 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

NRDC_HUMAN
θ value	0.00390308 (rank : 10)	NC score	0.241957 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
θ value	0.00390308 (rank : 11)	NC score	0.236334 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

IDE_HUMAN
θ value	0.00665767 (rank : 12)	NC score	0.227046 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

ACOX2_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.020571 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXD1	Gene names	Acox2
Domain Architecture
Description	Acyl-coenzyme A oxidase 2, peroxisomal (EC 1.17.99.3) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3- alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCCox) (THCA-CoA oxidase).

NARGL_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.018282 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBB4, Q3U7V2	Gene names	Narg1l, Nat2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

ADRB1_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.000804 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	864	Shared Neighborhood Hits	2
SwissProt Accessions	P34971	Gene names	Adrb1, Adrb1r
Domain Architecture
Description	Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 adrenoreceptor).

NARGL_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.016107 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	222	Shared Neighborhood Hits	3
SwissProt Accessions	Q6N069, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870	Gene names	NARG1L, NAT2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

NCOA6_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.004763 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	1076	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

Hits sorted by NC score

MPPA_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q10713, Q16639, Q8N513	Gene names	PMPCA, KIAA0123, MPPA
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPA_MOUSE
NC score	0.998686 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DC61, Q3TF19	Gene names	Pmpca, Inpp5e
Domain Architecture
Description	Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) (P-55).

MPPB_MOUSE
NC score	0.876799 (rank : 3)	θ value	2.3352e-48 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CXT8	Gene names	Pmpcb
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

MPPB_HUMAN
NC score	0.875982 (rank : 4)	θ value	1.788e-48 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	O75439, O60416, Q96FV4	Gene names	PMPCB, MPPB
Domain Architecture
Description	Mitochondrial-processing peptidase subunit beta, mitochondrial precursor (EC 3.4.24.64) (Beta-MPP) (P-52).

UQCR1_MOUSE
NC score	0.864338 (rank : 5)	θ value	6.58091e-43 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CZ13, Q9CWL6	Gene names	Uqcrc1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

UQCR1_HUMAN
NC score	0.858043 (rank : 6)	θ value	8.04462e-41 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	P31930, Q96DD2	Gene names	UQCRC1
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2).

UQCR2_MOUSE
NC score	0.805654 (rank : 7)	θ value	3.74554e-30 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DB77	Gene names	Uqcrc2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

UQCR2_HUMAN
NC score	0.799037 (rank : 8)	θ value	1.73987e-27 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	P22695, Q9BQ05	Gene names	UQCRC2
Domain Architecture
Description	Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit II).

NRDC_HUMAN
NC score	0.241957 (rank : 9)	θ value	0.00390308 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
NC score	0.236334 (rank : 10)	θ value	0.00390308 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

IDE_MOUSE
NC score	0.234860 (rank : 11)	θ value	0.00228821 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

IDE_HUMAN
NC score	0.227046 (rank : 12)	θ value	0.00665767 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	P14735	Gene names	IDE
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

ACOX2_MOUSE
NC score	0.020571 (rank : 13)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXD1	Gene names	Acox2
Domain Architecture
Description	Acyl-coenzyme A oxidase 2, peroxisomal (EC 1.17.99.3) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase) (3- alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase) (Trihydroxycoprostanoyl-CoA oxidase) (THCCox) (THCA-CoA oxidase).

NARGL_MOUSE
NC score	0.018282 (rank : 14)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBB4, Q3U7V2	Gene names	Narg1l, Nat2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

NARGL_HUMAN
NC score	0.016107 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	222	Shared Neighborhood Hits	3
SwissProt Accessions	Q6N069, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870	Gene names	NARG1L, NAT2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

NCOA6_MOUSE
NC score	0.004763 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	1076	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ADRB1_MOUSE
NC score	0.000804 (rank : 17)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	864	Shared Neighborhood Hits	2
SwissProt Accessions	P34971	Gene names	Adrb1, Adrb1r
Domain Architecture
Description	Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 adrenoreceptor).