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Network neighborhood for query Sequence : TEX14_HUMAN

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TEX14_HUMAN
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TEX14_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1103	Shared Neighborhood Hits	1103
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	0 (rank : 2)	NC score	0.939566 (rank : 2)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1333	Shared Neighborhood Hits	888
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TNI3K_HUMAN
θ value	1.29331e-14 (rank : 3)	NC score	0.766278 (rank : 3)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1084	Shared Neighborhood Hits	778
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

FRK_HUMAN
θ value	2.88119e-14 (rank : 4)	NC score	0.680998 (rank : 44)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1058	Shared Neighborhood Hits	579
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

KSYK_MOUSE
θ value	1.86753e-13 (rank : 5)	NC score	0.681090 (rank : 42)
Query Neighborhood Hits	1103	Target Neighborhood Hits	944	Shared Neighborhood Hits	565
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
θ value	2.43908e-13 (rank : 6)	NC score	0.681002 (rank : 43)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	562
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CSK_MOUSE
θ value	5.43371e-13 (rank : 7)	NC score	0.673979 (rank : 84)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	571
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

M3K11_HUMAN
θ value	5.43371e-13 (rank : 8)	NC score	0.655636 (rank : 140)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1136	Shared Neighborhood Hits	591
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ERBB4_HUMAN
θ value	7.09661e-13 (rank : 9)	NC score	0.691999 (rank : 15)
Query Neighborhood Hits	1103	Target Neighborhood Hits	910	Shared Neighborhood Hits	566
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

M3K13_HUMAN
θ value	7.09661e-13 (rank : 10)	NC score	0.651492 (rank : 153)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	572
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K12_HUMAN
θ value	1.2105e-12 (rank : 11)	NC score	0.654439 (rank : 143)
Query Neighborhood Hits	1103	Target Neighborhood Hits	940	Shared Neighborhood Hits	576
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	1.2105e-12 (rank : 12)	NC score	0.654317 (rank : 144)
Query Neighborhood Hits	1103	Target Neighborhood Hits	957	Shared Neighborhood Hits	579
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

TNI3K_MOUSE
θ value	1.2105e-12 (rank : 13)	NC score	0.762824 (rank : 4)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1079	Shared Neighborhood Hits	776
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

M3K9_HUMAN
θ value	1.58096e-12 (rank : 14)	NC score	0.655477 (rank : 141)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1123	Shared Neighborhood Hits	592
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	1.58096e-12 (rank : 15)	NC score	0.659699 (rank : 134)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1087	Shared Neighborhood Hits	594
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CSK_HUMAN
θ value	2.69671e-12 (rank : 16)	NC score	0.675432 (rank : 67)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	571
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

UFO_MOUSE
θ value	3.52202e-12 (rank : 17)	NC score	0.673986 (rank : 83)
Query Neighborhood Hits	1103	Target Neighborhood Hits	988	Shared Neighborhood Hits	553
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ZAP70_HUMAN
θ value	4.59992e-12 (rank : 18)	NC score	0.688997 (rank : 26)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	564
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ABL1_HUMAN
θ value	6.00763e-12 (rank : 19)	NC score	0.676003 (rank : 61)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1220	Shared Neighborhood Hits	606
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

M3K10_HUMAN
θ value	6.00763e-12 (rank : 20)	NC score	0.656922 (rank : 138)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1071	Shared Neighborhood Hits	585
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ABL1_MOUSE
θ value	1.02475e-11 (rank : 21)	NC score	0.675784 (rank : 62)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1178	Shared Neighborhood Hits	599
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FGR_MOUSE
θ value	1.02475e-11 (rank : 22)	NC score	0.674663 (rank : 78)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1069	Shared Neighborhood Hits	576
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TXK_HUMAN
θ value	1.02475e-11 (rank : 23)	NC score	0.690505 (rank : 20)
Query Neighborhood Hits	1103	Target Neighborhood Hits	971	Shared Neighborhood Hits	568
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

EGFR_HUMAN
θ value	2.98157e-11 (rank : 24)	NC score	0.691767 (rank : 16)
Query Neighborhood Hits	1103	Target Neighborhood Hits	939	Shared Neighborhood Hits	566
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

ZAP70_MOUSE
θ value	3.89403e-11 (rank : 25)	NC score	0.687036 (rank : 29)
Query Neighborhood Hits	1103	Target Neighborhood Hits	905	Shared Neighborhood Hits	566
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ABL2_HUMAN
θ value	5.08577e-11 (rank : 26)	NC score	0.677112 (rank : 54)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1045	Shared Neighborhood Hits	579
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

EGFR_MOUSE
θ value	5.08577e-11 (rank : 27)	NC score	0.691497 (rank : 17)
Query Neighborhood Hits	1103	Target Neighborhood Hits	927	Shared Neighborhood Hits	566
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	5.08577e-11 (rank : 28)	NC score	0.689103 (rank : 25)
Query Neighborhood Hits	1103	Target Neighborhood Hits	997	Shared Neighborhood Hits	575
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	6.64225e-11 (rank : 29)	NC score	0.687313 (rank : 28)
Query Neighborhood Hits	1103	Target Neighborhood Hits	958	Shared Neighborhood Hits	570
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

YES_HUMAN
θ value	1.47974e-10 (rank : 30)	NC score	0.675674 (rank : 64)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1059	Shared Neighborhood Hits	576
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPHB6_HUMAN
θ value	1.9326e-10 (rank : 31)	NC score	0.671884 (rank : 110)
Query Neighborhood Hits	1103	Target Neighborhood Hits	912	Shared Neighborhood Hits	536
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

MLTK_MOUSE
θ value	1.9326e-10 (rank : 32)	NC score	0.654272 (rank : 145)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	570
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

YES_MOUSE
θ value	1.9326e-10 (rank : 33)	NC score	0.675537 (rank : 65)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1052	Shared Neighborhood Hits	574
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
θ value	2.52405e-10 (rank : 34)	NC score	0.673221 (rank : 95)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1073	Shared Neighborhood Hits	576
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_HUMAN
θ value	2.52405e-10 (rank : 35)	NC score	0.673257 (rank : 94)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1058	Shared Neighborhood Hits	572
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_HUMAN
θ value	3.29651e-10 (rank : 36)	NC score	0.669801 (rank : 119)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1078	Shared Neighborhood Hits	575
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

MLTK_HUMAN
θ value	4.30538e-10 (rank : 37)	NC score	0.653987 (rank : 146)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	575
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

SRC_MOUSE
θ value	4.30538e-10 (rank : 38)	NC score	0.675075 (rank : 72)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1033	Shared Neighborhood Hits	572
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TXK_MOUSE
θ value	4.30538e-10 (rank : 39)	NC score	0.689474 (rank : 23)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	571
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ERBB2_HUMAN
θ value	5.62301e-10 (rank : 40)	NC score	0.689722 (rank : 22)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1073	Shared Neighborhood Hits	574
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

MATK_HUMAN
θ value	5.62301e-10 (rank : 41)	NC score	0.682566 (rank : 38)
Query Neighborhood Hits	1103	Target Neighborhood Hits	954	Shared Neighborhood Hits	567
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

TEC_MOUSE
θ value	5.62301e-10 (rank : 42)	NC score	0.679988 (rank : 46)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1006	Shared Neighborhood Hits	573
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

UFO_HUMAN
θ value	5.62301e-10 (rank : 43)	NC score	0.673386 (rank : 92)
Query Neighborhood Hits	1103	Target Neighborhood Hits	981	Shared Neighborhood Hits	549
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ERBB2_MOUSE
θ value	7.34386e-10 (rank : 44)	NC score	0.690466 (rank : 21)
Query Neighborhood Hits	1103	Target Neighborhood Hits	918	Shared Neighborhood Hits	568
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

LYN_MOUSE
θ value	7.34386e-10 (rank : 45)	NC score	0.672257 (rank : 106)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	576
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FGR_HUMAN
θ value	9.59137e-10 (rank : 46)	NC score	0.672216 (rank : 108)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1067	Shared Neighborhood Hits	576
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LCK_MOUSE
θ value	9.59137e-10 (rank : 47)	NC score	0.678295 (rank : 52)
Query Neighborhood Hits	1103	Target Neighborhood Hits	981	Shared Neighborhood Hits	574
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_HUMAN
θ value	9.59137e-10 (rank : 48)	NC score	0.672283 (rank : 105)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1022	Shared Neighborhood Hits	576
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NTRK3_HUMAN
θ value	9.59137e-10 (rank : 49)	NC score	0.660524 (rank : 132)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1115	Shared Neighborhood Hits	559
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PTK6_MOUSE
θ value	9.59137e-10 (rank : 50)	NC score	0.673421 (rank : 91)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	574
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TEC_HUMAN
θ value	9.59137e-10 (rank : 51)	NC score	0.681227 (rank : 41)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1006	Shared Neighborhood Hits	574
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ITK_MOUSE
θ value	1.25267e-09 (rank : 52)	NC score	0.683040 (rank : 36)
Query Neighborhood Hits	1103	Target Neighborhood Hits	985	Shared Neighborhood Hits	571
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TNK1_MOUSE
θ value	1.25267e-09 (rank : 53)	NC score	0.696791 (rank : 12)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	557
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

EPHB6_MOUSE
θ value	1.63604e-09 (rank : 54)	NC score	0.672377 (rank : 103)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	540
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ITK_HUMAN
θ value	1.63604e-09 (rank : 55)	NC score	0.682747 (rank : 37)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1016	Shared Neighborhood Hits	572
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BTK_HUMAN
θ value	2.13673e-09 (rank : 56)	NC score	0.674914 (rank : 76)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	574
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

HCK_MOUSE
θ value	2.13673e-09 (rank : 57)	NC score	0.676202 (rank : 59)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1029	Shared Neighborhood Hits	574
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

INSR_HUMAN
θ value	2.13673e-09 (rank : 58)	NC score	0.681427 (rank : 40)
Query Neighborhood Hits	1103	Target Neighborhood Hits	963	Shared Neighborhood Hits	569
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ANK2_HUMAN
θ value	2.79066e-09 (rank : 59)	NC score	0.407147 (rank : 808)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1615	Shared Neighborhood Hits	424
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANK3_HUMAN
θ value	2.79066e-09 (rank : 60)	NC score	0.423087 (rank : 741)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	350
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

BTK_MOUSE
θ value	2.79066e-09 (rank : 61)	NC score	0.675326 (rank : 69)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1017	Shared Neighborhood Hits	573
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

NTRK2_MOUSE
θ value	2.79066e-09 (rank : 62)	NC score	0.659327 (rank : 135)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1088	Shared Neighborhood Hits	558
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
θ value	3.64472e-09 (rank : 63)	NC score	0.659313 (rank : 136)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1081	Shared Neighborhood Hits	558
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

ANR44_HUMAN
θ value	4.76016e-09 (rank : 64)	NC score	0.425313 (rank : 739)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	245
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

EPHA3_HUMAN
θ value	4.76016e-09 (rank : 65)	NC score	0.672927 (rank : 98)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1005	Shared Neighborhood Hits	569
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

ALK_HUMAN
θ value	6.21693e-09 (rank : 66)	NC score	0.691184 (rank : 19)
Query Neighborhood Hits	1103	Target Neighborhood Hits	795	Shared Neighborhood Hits	542
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANK1_HUMAN
θ value	6.21693e-09 (rank : 67)	NC score	0.419970 (rank : 750)
Query Neighborhood Hits	1103	Target Neighborhood Hits	416	Shared Neighborhood Hits	262
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK1_MOUSE
θ value	6.21693e-09 (rank : 68)	NC score	0.420331 (rank : 747)
Query Neighborhood Hits	1103	Target Neighborhood Hits	430	Shared Neighborhood Hits	268
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

HCK_HUMAN
θ value	6.21693e-09 (rank : 69)	NC score	0.674047 (rank : 82)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1035	Shared Neighborhood Hits	572
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

PTK6_HUMAN
θ value	6.21693e-09 (rank : 70)	NC score	0.672309 (rank : 104)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1020	Shared Neighborhood Hits	574
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

ACK1_HUMAN
θ value	1.06045e-08 (rank : 71)	NC score	0.686054 (rank : 33)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1140	Shared Neighborhood Hits	608
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	1.06045e-08 (rank : 72)	NC score	0.685976 (rank : 34)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1080	Shared Neighborhood Hits	598
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EPHA5_MOUSE
θ value	1.06045e-08 (rank : 73)	NC score	0.685631 (rank : 35)
Query Neighborhood Hits	1103	Target Neighborhood Hits	950	Shared Neighborhood Hits	571
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

LCK_HUMAN
θ value	1.06045e-08 (rank : 74)	NC score	0.677085 (rank : 55)
Query Neighborhood Hits	1103	Target Neighborhood Hits	987	Shared Neighborhood Hits	575
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

M3K7_HUMAN
θ value	1.06045e-08 (rank : 75)	NC score	0.639494 (rank : 172)
Query Neighborhood Hits	1103	Target Neighborhood Hits	892	Shared Neighborhood Hits	572
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	1.06045e-08 (rank : 76)	NC score	0.639584 (rank : 171)
Query Neighborhood Hits	1103	Target Neighborhood Hits	892	Shared Neighborhood Hits	573
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MERTK_MOUSE
θ value	1.06045e-08 (rank : 77)	NC score	0.672069 (rank : 109)
Query Neighborhood Hits	1103	Target Neighborhood Hits	974	Shared Neighborhood Hits	553
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

TESK1_MOUSE
θ value	1.06045e-08 (rank : 78)	NC score	0.628507 (rank : 189)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	568
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

ANR50_HUMAN
θ value	1.38499e-08 (rank : 79)	NC score	0.430521 (rank : 722)
Query Neighborhood Hits	1103	Target Neighborhood Hits	361	Shared Neighborhood Hits	251
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANR52_MOUSE
θ value	1.38499e-08 (rank : 80)	NC score	0.420043 (rank : 749)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	241
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB8_HUMAN
θ value	1.38499e-08 (rank : 81)	NC score	0.432106 (rank : 718)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB8_MOUSE
θ value	1.38499e-08 (rank : 82)	NC score	0.431946 (rank : 719)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	238
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

EPHA5_HUMAN
θ value	1.38499e-08 (rank : 83)	NC score	0.675348 (rank : 68)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	574
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

ALK_MOUSE
θ value	1.80886e-08 (rank : 84)	NC score	0.691184 (rank : 18)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	546
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

EPHA2_HUMAN
θ value	1.80886e-08 (rank : 85)	NC score	0.678412 (rank : 51)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1021	Shared Neighborhood Hits	568
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	1.80886e-08 (rank : 86)	NC score	0.678451 (rank : 50)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1020	Shared Neighborhood Hits	566
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FAK1_HUMAN
θ value	1.80886e-08 (rank : 87)	NC score	0.687014 (rank : 30)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	567
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	1.80886e-08 (rank : 88)	NC score	0.686983 (rank : 31)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	565
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

TNK1_HUMAN
θ value	1.80886e-08 (rank : 89)	NC score	0.698275 (rank : 11)
Query Neighborhood Hits	1103	Target Neighborhood Hits	815	Shared Neighborhood Hits	566
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

EPHA7_MOUSE
θ value	2.36244e-08 (rank : 90)	NC score	0.671621 (rank : 112)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1025	Shared Neighborhood Hits	567
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

INSR_MOUSE
θ value	3.08544e-08 (rank : 91)	NC score	0.680804 (rank : 45)
Query Neighborhood Hits	1103	Target Neighborhood Hits	968	Shared Neighborhood Hits	567
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHA3_MOUSE
θ value	4.0297e-08 (rank : 92)	NC score	0.671706 (rank : 111)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	569
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

MATK_MOUSE
θ value	5.26297e-08 (rank : 93)	NC score	0.679314 (rank : 48)
Query Neighborhood Hits	1103	Target Neighborhood Hits	952	Shared Neighborhood Hits	568
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MLKL_MOUSE
θ value	5.26297e-08 (rank : 94)	NC score	0.673371 (rank : 93)
Query Neighborhood Hits	1103	Target Neighborhood Hits	707	Shared Neighborhood Hits	524
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ANR52_HUMAN
θ value	6.87365e-08 (rank : 95)	NC score	0.418880 (rank : 753)
Query Neighborhood Hits	1103	Target Neighborhood Hits	322	Shared Neighborhood Hits	241
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

EPHA7_HUMAN
θ value	6.87365e-08 (rank : 96)	NC score	0.670838 (rank : 116)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1053	Shared Neighborhood Hits	571
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FAK2_HUMAN
θ value	6.87365e-08 (rank : 97)	NC score	0.689198 (rank : 24)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	569
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

IGF1R_HUMAN
θ value	8.97725e-08 (rank : 98)	NC score	0.679107 (rank : 49)
Query Neighborhood Hits	1103	Target Neighborhood Hits	977	Shared Neighborhood Hits	562
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ROS_HUMAN
θ value	8.97725e-08 (rank : 99)	NC score	0.686947 (rank : 32)
Query Neighborhood Hits	1103	Target Neighborhood Hits	907	Shared Neighborhood Hits	549
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

ANR12_HUMAN
θ value	1.17247e-07 (rank : 100)	NC score	0.380217 (rank : 905)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1081	Shared Neighborhood Hits	394
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

TESK1_HUMAN
θ value	1.17247e-07 (rank : 101)	NC score	0.627646 (rank : 190)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	570
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

EPHA4_MOUSE
θ value	1.53129e-07 (rank : 102)	NC score	0.672795 (rank : 100)
Query Neighborhood Hits	1103	Target Neighborhood Hits	982	Shared Neighborhood Hits	573
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA8_HUMAN
θ value	1.53129e-07 (rank : 103)	NC score	0.676686 (rank : 57)
Query Neighborhood Hits	1103	Target Neighborhood Hits	956	Shared Neighborhood Hits	570
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FAK2_MOUSE
θ value	1.53129e-07 (rank : 104)	NC score	0.687425 (rank : 27)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	569
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EPHA4_HUMAN
θ value	1.99992e-07 (rank : 105)	NC score	0.672847 (rank : 99)
Query Neighborhood Hits	1103	Target Neighborhood Hits	975	Shared Neighborhood Hits	573
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

RN5A_MOUSE
θ value	1.99992e-07 (rank : 106)	NC score	0.558252 (rank : 242)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	657
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

TESK2_HUMAN
θ value	1.99992e-07 (rank : 107)	NC score	0.633117 (rank : 187)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	564
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ANR11_HUMAN
θ value	2.61198e-07 (rank : 108)	NC score	0.391109 (rank : 879)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1289	Shared Neighborhood Hits	405
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

EPHB1_HUMAN
θ value	2.61198e-07 (rank : 109)	NC score	0.673090 (rank : 96)
Query Neighborhood Hits	1103	Target Neighborhood Hits	988	Shared Neighborhood Hits	571
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

MERTK_HUMAN
θ value	2.61198e-07 (rank : 110)	NC score	0.667720 (rank : 123)
Query Neighborhood Hits	1103	Target Neighborhood Hits	988	Shared Neighborhood Hits	551
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

TESK2_MOUSE
θ value	2.61198e-07 (rank : 111)	NC score	0.633534 (rank : 184)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	563
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ERBB3_HUMAN
θ value	3.41135e-07 (rank : 112)	NC score	0.682193 (rank : 39)
Query Neighborhood Hits	1103	Target Neighborhood Hits	918	Shared Neighborhood Hits	563
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

FGFR4_HUMAN
θ value	3.41135e-07 (rank : 113)	NC score	0.651240 (rank : 155)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1037	Shared Neighborhood Hits	562
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

ANR28_MOUSE
θ value	4.45536e-07 (rank : 114)	NC score	0.421945 (rank : 745)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	243
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

EPHA8_MOUSE
θ value	4.45536e-07 (rank : 115)	NC score	0.676515 (rank : 58)
Query Neighborhood Hits	1103	Target Neighborhood Hits	969	Shared Neighborhood Hits	570
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB2_HUMAN
θ value	4.45536e-07 (rank : 116)	NC score	0.673558 (rank : 87)
Query Neighborhood Hits	1103	Target Neighborhood Hits	983	Shared Neighborhood Hits	568
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	4.45536e-07 (rank : 117)	NC score	0.673449 (rank : 90)
Query Neighborhood Hits	1103	Target Neighborhood Hits	982	Shared Neighborhood Hits	568
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

FGFR4_MOUSE
θ value	4.45536e-07 (rank : 118)	NC score	0.651525 (rank : 152)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	560
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

IGF1R_MOUSE
θ value	4.45536e-07 (rank : 119)	NC score	0.679327 (rank : 47)
Query Neighborhood Hits	1103	Target Neighborhood Hits	973	Shared Neighborhood Hits	561
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LTK_MOUSE
θ value	4.45536e-07 (rank : 120)	NC score	0.693193 (rank : 14)
Query Neighborhood Hits	1103	Target Neighborhood Hits	770	Shared Neighborhood Hits	543
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

RAI14_HUMAN
θ value	4.45536e-07 (rank : 121)	NC score	0.332087 (rank : 988)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1367	Shared Neighborhood Hits	372
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

SRMS_HUMAN
θ value	4.45536e-07 (rank : 122)	NC score	0.676705 (rank : 56)
Query Neighborhood Hits	1103	Target Neighborhood Hits	946	Shared Neighborhood Hits	570
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ULK1_MOUSE
θ value	4.45536e-07 (rank : 123)	NC score	0.544821 (rank : 252)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1214	Shared Neighborhood Hits	608
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ANR28_HUMAN
θ value	5.81887e-07 (rank : 124)	NC score	0.422296 (rank : 742)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	244
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ASB1_MOUSE
θ value	5.81887e-07 (rank : 125)	NC score	0.413112 (rank : 777)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	233
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ASB3_MOUSE
θ value	5.81887e-07 (rank : 126)	NC score	0.426408 (rank : 737)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	241
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

INSRR_MOUSE
θ value	5.81887e-07 (rank : 127)	NC score	0.675750 (rank : 63)
Query Neighborhood Hits	1103	Target Neighborhood Hits	961	Shared Neighborhood Hits	562
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

OXSR1_HUMAN
θ value	5.81887e-07 (rank : 128)	NC score	0.561979 (rank : 235)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	573
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

RET_HUMAN
θ value	5.81887e-07 (rank : 129)	NC score	0.676096 (rank : 60)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	560
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ANKK1_HUMAN
θ value	7.59969e-07 (rank : 130)	NC score	0.749819 (rank : 7)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1075	Shared Neighborhood Hits	775
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

IRAK3_MOUSE
θ value	7.59969e-07 (rank : 131)	NC score	0.618245 (rank : 199)
Query Neighborhood Hits	1103	Target Neighborhood Hits	628	Shared Neighborhood Hits	475
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KS6A2_MOUSE
θ value	7.59969e-07 (rank : 132)	NC score	0.508909 (rank : 386)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	571
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

ANR26_MOUSE
θ value	9.92553e-07 (rank : 133)	NC score	0.266087 (rank : 1040)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1554	Shared Neighborhood Hits	407
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

INSRR_HUMAN
θ value	9.92553e-07 (rank : 134)	NC score	0.674460 (rank : 80)
Query Neighborhood Hits	1103	Target Neighborhood Hits	950	Shared Neighborhood Hits	561
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KS6A2_HUMAN
θ value	9.92553e-07 (rank : 135)	NC score	0.509747 (rank : 380)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	569
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PAK7_HUMAN
θ value	9.92553e-07 (rank : 136)	NC score	0.534247 (rank : 274)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	566
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	9.92553e-07 (rank : 137)	NC score	0.533944 (rank : 276)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	566
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

RET_MOUSE
θ value	9.92553e-07 (rank : 138)	NC score	0.675145 (rank : 71)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	561
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TYRO3_HUMAN
θ value	9.92553e-07 (rank : 139)	NC score	0.661037 (rank : 130)
Query Neighborhood Hits	1103	Target Neighborhood Hits	995	Shared Neighborhood Hits	552
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

ASB15_HUMAN
θ value	1.29631e-06 (rank : 140)	NC score	0.409518 (rank : 795)
Query Neighborhood Hits	1103	Target Neighborhood Hits	305	Shared Neighborhood Hits	237
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB15_MOUSE
θ value	1.29631e-06 (rank : 141)	NC score	0.404609 (rank : 817)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB1_HUMAN
θ value	1.29631e-06 (rank : 142)	NC score	0.411795 (rank : 787)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

LTK_HUMAN
θ value	1.29631e-06 (rank : 143)	NC score	0.695014 (rank : 13)
Query Neighborhood Hits	1103	Target Neighborhood Hits	774	Shared Neighborhood Hits	545
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

TYRO3_MOUSE
θ value	1.29631e-06 (rank : 144)	NC score	0.661945 (rank : 128)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1007	Shared Neighborhood Hits	554
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

FANK1_HUMAN
θ value	1.69304e-06 (rank : 145)	NC score	0.429512 (rank : 724)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	242
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

FER_HUMAN
θ value	1.69304e-06 (rank : 146)	NC score	0.674989 (rank : 74)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1278	Shared Neighborhood Hits	636
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

JAK2_HUMAN
θ value	1.69304e-06 (rank : 147)	NC score	0.653691 (rank : 148)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	567
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

KPSH2_HUMAN
θ value	1.69304e-06 (rank : 148)	NC score	0.495970 (rank : 441)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	554
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

LRRK2_HUMAN
θ value	1.69304e-06 (rank : 149)	NC score	0.538724 (rank : 266)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1382	Shared Neighborhood Hits	580
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

PAK2_HUMAN
θ value	1.69304e-06 (rank : 150)	NC score	0.531280 (rank : 280)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	574
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	1.69304e-06 (rank : 151)	NC score	0.531425 (rank : 279)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	572
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

RAI14_MOUSE
θ value	1.69304e-06 (rank : 152)	NC score	0.324185 (rank : 993)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1505	Shared Neighborhood Hits	411
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ASB3_HUMAN
θ value	2.21117e-06 (rank : 153)	NC score	0.423516 (rank : 740)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	241
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

BMX_MOUSE
θ value	2.21117e-06 (rank : 154)	NC score	0.672402 (rank : 102)
Query Neighborhood Hits	1103	Target Neighborhood Hits	912	Shared Neighborhood Hits	559
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CTTB2_HUMAN
θ value	2.21117e-06 (rank : 155)	NC score	0.378905 (rank : 910)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1061	Shared Neighborhood Hits	357
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

EPHA6_HUMAN
θ value	2.21117e-06 (rank : 156)	NC score	0.674381 (rank : 81)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	565
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

JAK1_MOUSE
θ value	2.21117e-06 (rank : 157)	NC score	0.662503 (rank : 127)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	567
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_MOUSE
θ value	2.21117e-06 (rank : 158)	NC score	0.653780 (rank : 147)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	567
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

KS6A3_HUMAN
θ value	2.21117e-06 (rank : 159)	NC score	0.510465 (rank : 375)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	572
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	2.21117e-06 (rank : 160)	NC score	0.510468 (rank : 374)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	572
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PA2G6_MOUSE
θ value	2.21117e-06 (rank : 161)	NC score	0.411247 (rank : 789)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	237
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ULK1_HUMAN
θ value	2.21117e-06 (rank : 162)	NC score	0.544391 (rank : 256)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1121	Shared Neighborhood Hits	595
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

BLK_HUMAN
θ value	2.88788e-06 (rank : 163)	NC score	0.674985 (rank : 75)
Query Neighborhood Hits	1103	Target Neighborhood Hits	994	Shared Neighborhood Hits	575
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DAPK1_MOUSE
θ value	2.88788e-06 (rank : 164)	NC score	0.629798 (rank : 188)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1138	Shared Neighborhood Hits	783
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ERBB3_MOUSE
θ value	2.88788e-06 (rank : 165)	NC score	0.677962 (rank : 53)
Query Neighborhood Hits	1103	Target Neighborhood Hits	898	Shared Neighborhood Hits	561
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

JAK1_HUMAN
θ value	2.88788e-06 (rank : 166)	NC score	0.662591 (rank : 126)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	569
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

RAF1_HUMAN
θ value	2.88788e-06 (rank : 167)	NC score	0.636966 (rank : 178)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	570
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

SRMS_MOUSE
θ value	2.88788e-06 (rank : 168)	NC score	0.673086 (rank : 97)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	567
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ANKS1_HUMAN
θ value	3.77169e-06 (rank : 169)	NC score	0.420247 (rank : 748)
Query Neighborhood Hits	1103	Target Neighborhood Hits	438	Shared Neighborhood Hits	275
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

EPHB4_HUMAN
θ value	3.77169e-06 (rank : 170)	NC score	0.675535 (rank : 66)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1056	Shared Neighborhood Hits	575
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

KPSH1_HUMAN
θ value	3.77169e-06 (rank : 171)	NC score	0.486448 (rank : 482)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	557
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	3.77169e-06 (rank : 172)	NC score	0.487419 (rank : 479)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	558
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

LIMK1_MOUSE
θ value	3.77169e-06 (rank : 173)	NC score	0.603103 (rank : 214)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1008	Shared Neighborhood Hits	572
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LRRK2_MOUSE
θ value	3.77169e-06 (rank : 174)	NC score	0.531175 (rank : 281)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1359	Shared Neighborhood Hits	582
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

EPHA6_MOUSE
θ value	4.92598e-06 (rank : 175)	NC score	0.675254 (rank : 70)
Query Neighborhood Hits	1103	Target Neighborhood Hits	946	Shared Neighborhood Hits	568
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB4_MOUSE
θ value	4.92598e-06 (rank : 176)	NC score	0.674713 (rank : 77)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1013	Shared Neighborhood Hits	571
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FGFR2_HUMAN
θ value	4.92598e-06 (rank : 177)	NC score	0.646961 (rank : 159)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1062	Shared Neighborhood Hits	564
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	4.92598e-06 (rank : 178)	NC score	0.649059 (rank : 157)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1062	Shared Neighborhood Hits	564
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

KGP2_MOUSE
θ value	4.92598e-06 (rank : 179)	NC score	0.482008 (rank : 508)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1029	Shared Neighborhood Hits	597
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6B2_HUMAN
θ value	4.92598e-06 (rank : 180)	NC score	0.480853 (rank : 521)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	568
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PSD10_MOUSE
θ value	4.92598e-06 (rank : 181)	NC score	0.427462 (rank : 732)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	240
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR42_MOUSE
θ value	6.43352e-06 (rank : 182)	NC score	0.417194 (rank : 760)
Query Neighborhood Hits	1103	Target Neighborhood Hits	334	Shared Neighborhood Hits	243
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

KGP2_HUMAN
θ value	6.43352e-06 (rank : 183)	NC score	0.482356 (rank : 503)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	597
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6B2_MOUSE
θ value	6.43352e-06 (rank : 184)	NC score	0.476564 (rank : 546)
Query Neighborhood Hits	1103	Target Neighborhood Hits	871	Shared Neighborhood Hits	569
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PAK6_HUMAN
θ value	6.43352e-06 (rank : 185)	NC score	0.532536 (rank : 278)
Query Neighborhood Hits	1103	Target Neighborhood Hits	915	Shared Neighborhood Hits	577
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PTK7_HUMAN
θ value	6.43352e-06 (rank : 186)	NC score	0.611056 (rank : 206)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1103	Shared Neighborhood Hits	559
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

STK24_HUMAN
θ value	6.43352e-06 (rank : 187)	NC score	0.563465 (rank : 231)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	568
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

EPHB3_HUMAN
θ value	8.40245e-06 (rank : 188)	NC score	0.672257 (rank : 107)
Query Neighborhood Hits	1103	Target Neighborhood Hits	996	Shared Neighborhood Hits	570
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	8.40245e-06 (rank : 189)	NC score	0.671523 (rank : 113)
Query Neighborhood Hits	1103	Target Neighborhood Hits	996	Shared Neighborhood Hits	569
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FANK1_MOUSE
θ value	8.40245e-06 (rank : 190)	NC score	0.434201 (rank : 714)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	246
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

RIPK1_HUMAN
θ value	8.40245e-06 (rank : 191)	NC score	0.627181 (rank : 192)
Query Neighborhood Hits	1103	Target Neighborhood Hits	891	Shared Neighborhood Hits	572
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ASB13_MOUSE
θ value	1.09739e-05 (rank : 192)	NC score	0.417236 (rank : 759)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	239
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB2_HUMAN
θ value	1.09739e-05 (rank : 193)	NC score	0.417193 (rank : 761)
Query Neighborhood Hits	1103	Target Neighborhood Hits	309	Shared Neighborhood Hits	244
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

CLPB_MOUSE
θ value	1.09739e-05 (rank : 194)	NC score	0.352963 (rank : 961)
Query Neighborhood Hits	1103	Target Neighborhood Hits	289	Shared Neighborhood Hits	216
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

FGFR3_HUMAN
θ value	1.09739e-05 (rank : 195)	NC score	0.648845 (rank : 158)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1042	Shared Neighborhood Hits	565
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

GUC2D_HUMAN
θ value	1.09739e-05 (rank : 196)	NC score	0.528606 (rank : 293)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	514
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

ILK1_HUMAN
θ value	1.09739e-05 (rank : 197)	NC score	0.750907 (rank : 6)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	684
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

PSD10_HUMAN
θ value	1.09739e-05 (rank : 198)	NC score	0.426339 (rank : 738)
Query Neighborhood Hits	1103	Target Neighborhood Hits	301	Shared Neighborhood Hits	241
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

STK24_MOUSE
θ value	1.09739e-05 (rank : 199)	NC score	0.564298 (rank : 230)
Query Neighborhood Hits	1103	Target Neighborhood Hits	856	Shared Neighborhood Hits	567
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STYK1_HUMAN
θ value	1.09739e-05 (rank : 200)	NC score	0.674569 (rank : 79)
Query Neighborhood Hits	1103	Target Neighborhood Hits	786	Shared Neighborhood Hits	547
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ANKS1_MOUSE
θ value	1.43324e-05 (rank : 201)	NC score	0.416474 (rank : 764)
Query Neighborhood Hits	1103	Target Neighborhood Hits	453	Shared Neighborhood Hits	279
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ASB13_HUMAN
θ value	1.43324e-05 (rank : 202)	NC score	0.417280 (rank : 758)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	239
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

BMX_HUMAN
θ value	1.43324e-05 (rank : 203)	NC score	0.671275 (rank : 114)
Query Neighborhood Hits	1103	Target Neighborhood Hits	942	Shared Neighborhood Hits	561
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

OSBL1_HUMAN
θ value	1.43324e-05 (rank : 204)	NC score	0.328023 (rank : 991)
Query Neighborhood Hits	1103	Target Neighborhood Hits	368	Shared Neighborhood Hits	249
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_MOUSE
θ value	1.43324e-05 (rank : 205)	NC score	0.322139 (rank : 996)
Query Neighborhood Hits	1103	Target Neighborhood Hits	336	Shared Neighborhood Hits	238
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PAK1_HUMAN
θ value	1.43324e-05 (rank : 206)	NC score	0.527965 (rank : 299)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	570
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	1.43324e-05 (rank : 207)	NC score	0.527921 (rank : 300)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	573
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PLK3_MOUSE
θ value	1.43324e-05 (rank : 208)	NC score	0.513295 (rank : 350)
Query Neighborhood Hits	1103	Target Neighborhood Hits	863	Shared Neighborhood Hits	567
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

RAF1_MOUSE
θ value	1.43324e-05 (rank : 209)	NC score	0.634426 (rank : 181)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	570
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ANFY1_HUMAN
θ value	1.87187e-05 (rank : 210)	NC score	0.368312 (rank : 929)
Query Neighborhood Hits	1103	Target Neighborhood Hits	480	Shared Neighborhood Hits	247
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANKK1_MOUSE
θ value	1.87187e-05 (rank : 211)	NC score	0.744374 (rank : 10)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1072	Shared Neighborhood Hits	775
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

DDR1_HUMAN
θ value	1.87187e-05 (rank : 212)	NC score	0.665914 (rank : 125)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	549
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	1.87187e-05 (rank : 213)	NC score	0.666979 (rank : 124)
Query Neighborhood Hits	1103	Target Neighborhood Hits	818	Shared Neighborhood Hits	549
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

INVS_HUMAN
θ value	1.87187e-05 (rank : 214)	NC score	0.418983 (rank : 752)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	267
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

INVS_MOUSE
θ value	1.87187e-05 (rank : 215)	NC score	0.415320 (rank : 769)
Query Neighborhood Hits	1103	Target Neighborhood Hits	609	Shared Neighborhood Hits	289
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

KGP1A_HUMAN
θ value	1.87187e-05 (rank : 216)	NC score	0.480949 (rank : 519)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	572
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	1.87187e-05 (rank : 217)	NC score	0.480933 (rank : 520)
Query Neighborhood Hits	1103	Target Neighborhood Hits	921	Shared Neighborhood Hits	576
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	1.87187e-05 (rank : 218)	NC score	0.480971 (rank : 518)
Query Neighborhood Hits	1103	Target Neighborhood Hits	922	Shared Neighborhood Hits	576
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KPCD2_HUMAN
θ value	1.87187e-05 (rank : 219)	NC score	0.496971 (rank : 436)
Query Neighborhood Hits	1103	Target Neighborhood Hits	910	Shared Neighborhood Hits	562
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

MET_HUMAN
θ value	1.87187e-05 (rank : 220)	NC score	0.670735 (rank : 117)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	561
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

PLK3_HUMAN
θ value	1.87187e-05 (rank : 221)	NC score	0.512374 (rank : 356)
Query Neighborhood Hits	1103	Target Neighborhood Hits	865	Shared Neighborhood Hits	568
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

RIPK2_MOUSE
θ value	1.87187e-05 (rank : 222)	NC score	0.615853 (rank : 201)
Query Neighborhood Hits	1103	Target Neighborhood Hits	776	Shared Neighborhood Hits	535
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

A20A1_HUMAN
θ value	2.44474e-05 (rank : 223)	NC score	0.354463 (rank : 956)
Query Neighborhood Hits	1103	Target Neighborhood Hits	698	Shared Neighborhood Hits	310
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A2_HUMAN
θ value	2.44474e-05 (rank : 224)	NC score	0.354595 (rank : 955)
Query Neighborhood Hits	1103	Target Neighborhood Hits	716	Shared Neighborhood Hits	312
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A3_HUMAN
θ value	2.44474e-05 (rank : 225)	NC score	0.355371 (rank : 954)
Query Neighborhood Hits	1103	Target Neighborhood Hits	692	Shared Neighborhood Hits	310
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	2.44474e-05 (rank : 226)	NC score	0.353445 (rank : 959)
Query Neighborhood Hits	1103	Target Neighborhood Hits	710	Shared Neighborhood Hits	310
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

DAPK1_HUMAN
θ value	2.44474e-05 (rank : 227)	NC score	0.626390 (rank : 194)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1130	Shared Neighborhood Hits	781
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

FGFR3_MOUSE
θ value	2.44474e-05 (rank : 228)	NC score	0.646271 (rank : 162)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1059	Shared Neighborhood Hits	565
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

ILK_MOUSE
θ value	2.44474e-05 (rank : 229)	NC score	0.751517 (rank : 5)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	687
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

IRAK3_HUMAN
θ value	2.44474e-05 (rank : 230)	NC score	0.606608 (rank : 211)
Query Neighborhood Hits	1103	Target Neighborhood Hits	644	Shared Neighborhood Hits	485
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KS6B1_HUMAN
θ value	2.44474e-05 (rank : 231)	NC score	0.483039 (rank : 499)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	566
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	2.44474e-05 (rank : 232)	NC score	0.483092 (rank : 498)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	565
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

NTRK1_HUMAN
θ value	2.44474e-05 (rank : 233)	NC score	0.670855 (rank : 115)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	553
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

OXSR1_MOUSE
θ value	2.44474e-05 (rank : 234)	NC score	0.560614 (rank : 238)
Query Neighborhood Hits	1103	Target Neighborhood Hits	865	Shared Neighborhood Hits	572
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ZDH17_HUMAN
θ value	2.44474e-05 (rank : 235)	NC score	0.367781 (rank : 933)
Query Neighborhood Hits	1103	Target Neighborhood Hits	334	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ZDH17_MOUSE
θ value	2.44474e-05 (rank : 236)	NC score	0.365785 (rank : 940)
Query Neighborhood Hits	1103	Target Neighborhood Hits	328	Shared Neighborhood Hits	236
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

AL2S2_HUMAN
θ value	3.19293e-05 (rank : 237)	NC score	0.527266 (rank : 302)
Query Neighborhood Hits	1103	Target Neighborhood Hits	727	Shared Neighborhood Hits	531
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

ANKS6_MOUSE
θ value	3.19293e-05 (rank : 238)	NC score	0.410965 (rank : 791)
Query Neighborhood Hits	1103	Target Neighborhood Hits	435	Shared Neighborhood Hits	255
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANR35_HUMAN
θ value	3.19293e-05 (rank : 239)	NC score	0.392948 (rank : 870)
Query Neighborhood Hits	1103	Target Neighborhood Hits	784	Shared Neighborhood Hits	300
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

BLK_MOUSE
θ value	3.19293e-05 (rank : 240)	NC score	0.673454 (rank : 89)
Query Neighborhood Hits	1103	Target Neighborhood Hits	992	Shared Neighborhood Hits	574
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CSF1R_MOUSE
θ value	3.19293e-05 (rank : 241)	NC score	0.638434 (rank : 175)
Query Neighborhood Hits	1103	Target Neighborhood Hits	983	Shared Neighborhood Hits	555
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FLT3_MOUSE
θ value	3.19293e-05 (rank : 242)	NC score	0.652790 (rank : 150)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	557
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

NUAK2_MOUSE
θ value	3.19293e-05 (rank : 243)	NC score	0.516243 (rank : 340)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	570
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

ANKS3_MOUSE
θ value	4.1701e-05 (rank : 244)	NC score	0.411939 (rank : 785)
Query Neighborhood Hits	1103	Target Neighborhood Hits	355	Shared Neighborhood Hits	246
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

FLT3_HUMAN
θ value	4.1701e-05 (rank : 245)	NC score	0.654572 (rank : 142)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	556
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

IKBE_HUMAN
θ value	4.1701e-05 (rank : 246)	NC score	0.389437 (rank : 885)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	235
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

MIB1_HUMAN
θ value	4.1701e-05 (rank : 247)	NC score	0.395469 (rank : 852)
Query Neighborhood Hits	1103	Target Neighborhood Hits	470	Shared Neighborhood Hits	245
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	4.1701e-05 (rank : 248)	NC score	0.395228 (rank : 855)
Query Neighborhood Hits	1103	Target Neighborhood Hits	471	Shared Neighborhood Hits	246
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MOS_MOUSE
θ value	4.1701e-05 (rank : 249)	NC score	0.620506 (rank : 197)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	566
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

NEK4_MOUSE
θ value	4.1701e-05 (rank : 250)	NC score	0.549694 (rank : 246)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	575
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

PAK3_HUMAN
θ value	4.1701e-05 (rank : 251)	NC score	0.525409 (rank : 305)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	574
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	4.1701e-05 (rank : 252)	NC score	0.525685 (rank : 304)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	572
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

SHAN1_HUMAN
θ value	4.1701e-05 (rank : 253)	NC score	0.385616 (rank : 900)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1041	Shared Neighborhood Hits	330
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

AL2S2_MOUSE
θ value	5.44631e-05 (rank : 254)	NC score	0.524859 (rank : 307)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	520
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

FGFR1_HUMAN
θ value	5.44631e-05 (rank : 255)	NC score	0.643341 (rank : 168)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1069	Shared Neighborhood Hits	565
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	5.44631e-05 (rank : 256)	NC score	0.643445 (rank : 167)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1068	Shared Neighborhood Hits	565
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

GIT1_HUMAN
θ value	5.44631e-05 (rank : 257)	NC score	0.277643 (rank : 1034)
Query Neighborhood Hits	1103	Target Neighborhood Hits	336	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	5.44631e-05 (rank : 258)	NC score	0.278433 (rank : 1032)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	241
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

IKBE_MOUSE
θ value	5.44631e-05 (rank : 259)	NC score	0.393827 (rank : 866)
Query Neighborhood Hits	1103	Target Neighborhood Hits	308	Shared Neighborhood Hits	240
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

KS6A6_HUMAN
θ value	5.44631e-05 (rank : 260)	NC score	0.502450 (rank : 419)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	569
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

PA2G6_HUMAN
θ value	5.44631e-05 (rank : 261)	NC score	0.409582 (rank : 794)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	234
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

PP16A_MOUSE
θ value	5.44631e-05 (rank : 262)	NC score	0.400098 (rank : 836)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	240
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

TYK2_HUMAN
θ value	5.44631e-05 (rank : 263)	NC score	0.651379 (rank : 154)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	567
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	5.44631e-05 (rank : 264)	NC score	0.652110 (rank : 151)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	568
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

ANR19_HUMAN
θ value	7.1131e-05 (rank : 265)	NC score	0.384533 (rank : 901)
Query Neighborhood Hits	1103	Target Neighborhood Hits	276	Shared Neighborhood Hits	234
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ASB14_MOUSE
θ value	7.1131e-05 (rank : 266)	NC score	0.403967 (rank : 820)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	237
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

BRAF1_HUMAN
θ value	7.1131e-05 (rank : 267)	NC score	0.637495 (rank : 177)
Query Neighborhood Hits	1103	Target Neighborhood Hits	883	Shared Neighborhood Hits	568
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CDN2D_HUMAN
θ value	7.1131e-05 (rank : 268)	NC score	0.409511 (rank : 796)
Query Neighborhood Hits	1103	Target Neighborhood Hits	268	Shared Neighborhood Hits	234
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

EPHAA_HUMAN
θ value	7.1131e-05 (rank : 269)	NC score	0.667848 (rank : 122)
Query Neighborhood Hits	1103	Target Neighborhood Hits	960	Shared Neighborhood Hits	559
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

LIMK1_HUMAN
θ value	7.1131e-05 (rank : 270)	NC score	0.602393 (rank : 215)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1005	Shared Neighborhood Hits	571
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

NUAK2_HUMAN
θ value	7.1131e-05 (rank : 271)	NC score	0.520281 (rank : 322)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	571
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PAK4_MOUSE
θ value	7.1131e-05 (rank : 272)	NC score	0.523684 (rank : 311)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1098	Shared Neighborhood Hits	591
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

RON_MOUSE
θ value	7.1131e-05 (rank : 273)	NC score	0.673976 (rank : 85)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	561
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

STK25_MOUSE
θ value	7.1131e-05 (rank : 274)	NC score	0.558410 (rank : 241)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	569
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

UACA_HUMAN
θ value	7.1131e-05 (rank : 275)	NC score	0.278806 (rank : 1031)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1622	Shared Neighborhood Hits	395
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

AN30A_HUMAN
θ value	9.29e-05 (rank : 276)	NC score	0.322032 (rank : 997)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1119	Shared Neighborhood Hits	390
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANKR1_MOUSE
θ value	9.29e-05 (rank : 277)	NC score	0.416048 (rank : 765)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	241
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANR23_HUMAN
θ value	9.29e-05 (rank : 278)	NC score	0.419473 (rank : 751)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	238
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

GUC2E_MOUSE
θ value	9.29e-05 (rank : 279)	NC score	0.529991 (rank : 283)
Query Neighborhood Hits	1103	Target Neighborhood Hits	692	Shared Neighborhood Hits	504
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

MYPT2_HUMAN
θ value	9.29e-05 (rank : 280)	NC score	0.394836 (rank : 859)
Query Neighborhood Hits	1103	Target Neighborhood Hits	707	Shared Neighborhood Hits	302
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

OSTF1_MOUSE
θ value	9.29e-05 (rank : 281)	NC score	0.394457 (rank : 860)
Query Neighborhood Hits	1103	Target Neighborhood Hits	467	Shared Neighborhood Hits	256
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PGFRB_HUMAN
θ value	9.29e-05 (rank : 282)	NC score	0.644857 (rank : 164)
Query Neighborhood Hits	1103	Target Neighborhood Hits	962	Shared Neighborhood Hits	555
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ROR1_HUMAN
θ value	9.29e-05 (rank : 283)	NC score	0.661516 (rank : 129)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1018	Shared Neighborhood Hits	565
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ULK3_MOUSE
θ value	9.29e-05 (rank : 284)	NC score	0.528440 (rank : 295)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	567
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ANFY1_MOUSE
θ value	0.000121331 (rank : 285)	NC score	0.366219 (rank : 938)
Query Neighborhood Hits	1103	Target Neighborhood Hits	480	Shared Neighborhood Hits	247
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ILK2_HUMAN
θ value	0.000121331 (rank : 286)	NC score	0.744583 (rank : 9)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	677
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

JAK3_MOUSE
θ value	0.000121331 (rank : 287)	NC score	0.642578 (rank : 169)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	558
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KS6A1_HUMAN
θ value	0.000121331 (rank : 288)	NC score	0.509145 (rank : 383)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	572
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

M3K2_MOUSE
θ value	0.000121331 (rank : 289)	NC score	0.529034 (rank : 290)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	562
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

RON_HUMAN
θ value	0.000121331 (rank : 290)	NC score	0.673538 (rank : 88)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_MOUSE
θ value	0.000121331 (rank : 291)	NC score	0.660861 (rank : 131)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1025	Shared Neighborhood Hits	565
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

STK25_HUMAN
θ value	0.000121331 (rank : 292)	NC score	0.557849 (rank : 243)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	570
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

TIE2_HUMAN
θ value	0.000121331 (rank : 293)	NC score	0.646373 (rank : 161)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1192	Shared Neighborhood Hits	567
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

UACA_MOUSE
θ value	0.000121331 (rank : 294)	NC score	0.268671 (rank : 1039)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1620	Shared Neighborhood Hits	407
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

YSK4_HUMAN
θ value	0.000121331 (rank : 295)	NC score	0.569983 (rank : 228)
Query Neighborhood Hits	1103	Target Neighborhood Hits	921	Shared Neighborhood Hits	583
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ANR41_HUMAN
θ value	0.000158464 (rank : 296)	NC score	0.389917 (rank : 882)
Query Neighborhood Hits	1103	Target Neighborhood Hits	332	Shared Neighborhood Hits	223
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

CSF1R_HUMAN
θ value	0.000158464 (rank : 297)	NC score	0.644437 (rank : 165)
Query Neighborhood Hits	1103	Target Neighborhood Hits	943	Shared Neighborhood Hits	554
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

GABP2_HUMAN
θ value	0.000158464 (rank : 298)	NC score	0.412708 (rank : 779)
Query Neighborhood Hits	1103	Target Neighborhood Hits	454	Shared Neighborhood Hits	277
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

IKKB_HUMAN
θ value	0.000158464 (rank : 299)	NC score	0.546982 (rank : 248)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	595
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

NIM1_MOUSE
θ value	0.000158464 (rank : 300)	NC score	0.511261 (rank : 363)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	565
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

STK39_HUMAN
θ value	0.000158464 (rank : 301)	NC score	0.562025 (rank : 234)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	574
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	0.000158464 (rank : 302)	NC score	0.561899 (rank : 236)
Query Neighborhood Hits	1103	Target Neighborhood Hits	915	Shared Neighborhood Hits	581
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TIE2_MOUSE
θ value	0.000158464 (rank : 303)	NC score	0.646057 (rank : 163)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1204	Shared Neighborhood Hits	567
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

ANKR1_HUMAN
θ value	0.00020696 (rank : 304)	NC score	0.415807 (rank : 768)
Query Neighborhood Hits	1103	Target Neighborhood Hits	308	Shared Neighborhood Hits	244
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ANKS6_HUMAN
θ value	0.00020696 (rank : 305)	NC score	0.407175 (rank : 807)
Query Neighborhood Hits	1103	Target Neighborhood Hits	411	Shared Neighborhood Hits	252
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANRA2_HUMAN
θ value	0.00020696 (rank : 306)	NC score	0.401727 (rank : 828)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	234
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASB2_MOUSE
θ value	0.00020696 (rank : 307)	NC score	0.412528 (rank : 781)
Query Neighborhood Hits	1103	Target Neighborhood Hits	321	Shared Neighborhood Hits	244
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

CDK4_MOUSE
θ value	0.00020696 (rank : 308)	NC score	0.496690 (rank : 437)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	564
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

DSPP_MOUSE
θ value	0.00020696 (rank : 309)	NC score	0.073718 (rank : 1259)
Query Neighborhood Hits	1103	Target Neighborhood Hits	491	Shared Neighborhood Hits	95
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

IKKB_MOUSE
θ value	0.00020696 (rank : 310)	NC score	0.543666 (rank : 257)
Query Neighborhood Hits	1103	Target Neighborhood Hits	984	Shared Neighborhood Hits	591
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MLKL_HUMAN
θ value	0.00020696 (rank : 311)	NC score	0.635631 (rank : 180)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	444
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MST4_HUMAN
θ value	0.00020696 (rank : 312)	NC score	0.558802 (rank : 239)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	570
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	0.00020696 (rank : 313)	NC score	0.558620 (rank : 240)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	570
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYST3_MOUSE
θ value	0.00020696 (rank : 314)	NC score	0.059535 (rank : 1412)
Query Neighborhood Hits	1103	Target Neighborhood Hits	688	Shared Neighborhood Hits	142
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

NUAK1_MOUSE
θ value	0.00020696 (rank : 315)	NC score	0.519013 (rank : 328)
Query Neighborhood Hits	1103	Target Neighborhood Hits	881	Shared Neighborhood Hits	572
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

PAK4_HUMAN
θ value	0.00020696 (rank : 316)	NC score	0.524035 (rank : 310)
Query Neighborhood Hits	1103	Target Neighborhood Hits	924	Shared Neighborhood Hits	577
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

STK16_MOUSE
θ value	0.00020696 (rank : 317)	NC score	0.536686 (rank : 270)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	552
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

ANKR2_MOUSE
θ value	0.000270298 (rank : 318)	NC score	0.416026 (rank : 766)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	244
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

ANR39_MOUSE
θ value	0.000270298 (rank : 319)	NC score	0.413927 (rank : 771)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	238
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR42_HUMAN
θ value	0.000270298 (rank : 320)	NC score	0.413207 (rank : 774)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	236
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

CI096_HUMAN
θ value	0.000270298 (rank : 321)	NC score	0.539205 (rank : 264)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	552
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CSKP_HUMAN
θ value	0.000270298 (rank : 322)	NC score	0.439006 (rank : 707)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1022	Shared Neighborhood Hits	552
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	0.000270298 (rank : 323)	NC score	0.440223 (rank : 703)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1027	Shared Neighborhood Hits	552
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

GUC2F_HUMAN
θ value	0.000270298 (rank : 324)	NC score	0.578290 (rank : 222)
Query Neighborhood Hits	1103	Target Neighborhood Hits	740	Shared Neighborhood Hits	521
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

MAST2_HUMAN
θ value	0.000270298 (rank : 325)	NC score	0.448728 (rank : 684)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1189	Shared Neighborhood Hits	610
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MET_MOUSE
θ value	0.000270298 (rank : 326)	NC score	0.669494 (rank : 120)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	561
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MYPT1_HUMAN
θ value	0.000270298 (rank : 327)	NC score	0.396568 (rank : 849)
Query Neighborhood Hits	1103	Target Neighborhood Hits	723	Shared Neighborhood Hits	330
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

NUAK1_HUMAN
θ value	0.000270298 (rank : 328)	NC score	0.519394 (rank : 327)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	565
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

ROR2_HUMAN
θ value	0.000270298 (rank : 329)	NC score	0.656603 (rank : 139)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1014	Shared Neighborhood Hits	565
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ANR39_HUMAN
θ value	0.00035302 (rank : 330)	NC score	0.413733 (rank : 772)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	238
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ASB4_HUMAN
θ value	0.00035302 (rank : 331)	NC score	0.393092 (rank : 868)
Query Neighborhood Hits	1103	Target Neighborhood Hits	264	Shared Neighborhood Hits	228
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

CDK6_HUMAN
θ value	0.00035302 (rank : 332)	NC score	0.501845 (rank : 422)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	563
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	0.00035302 (rank : 333)	NC score	0.503573 (rank : 414)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	563
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

DDR2_MOUSE
θ value	0.00035302 (rank : 334)	NC score	0.659745 (rank : 133)
Query Neighborhood Hits	1103	Target Neighborhood Hits	813	Shared Neighborhood Hits	555
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

GIT2_MOUSE
θ value	0.00035302 (rank : 335)	NC score	0.281195 (rank : 1028)
Query Neighborhood Hits	1103	Target Neighborhood Hits	323	Shared Neighborhood Hits	236
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

M3K2_HUMAN
θ value	0.00035302 (rank : 336)	NC score	0.534191 (rank : 275)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	563
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MAK_MOUSE
θ value	0.00035302 (rank : 337)	NC score	0.505561 (rank : 404)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	567
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAST2_MOUSE
θ value	0.00035302 (rank : 338)	NC score	0.449481 (rank : 678)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1110	Shared Neighborhood Hits	594
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NEK4_HUMAN
θ value	0.00035302 (rank : 339)	NC score	0.547331 (rank : 247)
Query Neighborhood Hits	1103	Target Neighborhood Hits	883	Shared Neighborhood Hits	568
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PGFRB_MOUSE
θ value	0.00035302 (rank : 340)	NC score	0.642561 (rank : 170)
Query Neighborhood Hits	1103	Target Neighborhood Hits	960	Shared Neighborhood Hits	556
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RIPK2_HUMAN
θ value	0.00035302 (rank : 341)	NC score	0.613615 (rank : 204)
Query Neighborhood Hits	1103	Target Neighborhood Hits	774	Shared Neighborhood Hits	538
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

ANKR2_HUMAN
θ value	0.000461057 (rank : 342)	NC score	0.417436 (rank : 756)
Query Neighborhood Hits	1103	Target Neighborhood Hits	321	Shared Neighborhood Hits	248
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANKS3_HUMAN
θ value	0.000461057 (rank : 343)	NC score	0.406697 (rank : 809)
Query Neighborhood Hits	1103	Target Neighborhood Hits	355	Shared Neighborhood Hits	253
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANKY2_MOUSE
θ value	0.000461057 (rank : 344)	NC score	0.367900 (rank : 932)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	236
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR23_MOUSE
θ value	0.000461057 (rank : 345)	NC score	0.417775 (rank : 754)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	239
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

GABP2_MOUSE
θ value	0.000461057 (rank : 346)	NC score	0.412701 (rank : 780)
Query Neighborhood Hits	1103	Target Neighborhood Hits	429	Shared Neighborhood Hits	272
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

IKKE_HUMAN
θ value	0.000461057 (rank : 347)	NC score	0.528990 (rank : 291)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	557
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MIB2_MOUSE
θ value	0.000461057 (rank : 348)	NC score	0.386765 (rank : 894)
Query Neighborhood Hits	1103	Target Neighborhood Hits	409	Shared Neighborhood Hits	239
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

OSTF1_HUMAN
θ value	0.000461057 (rank : 349)	NC score	0.392006 (rank : 875)
Query Neighborhood Hits	1103	Target Neighborhood Hits	466	Shared Neighborhood Hits	257
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

POTE8_HUMAN
θ value	0.000461057 (rank : 350)	NC score	0.386376 (rank : 896)
Query Neighborhood Hits	1103	Target Neighborhood Hits	337	Shared Neighborhood Hits	249
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

STK11_HUMAN
θ value	0.000461057 (rank : 351)	NC score	0.514629 (rank : 345)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	559
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STYK1_MOUSE
θ value	0.000461057 (rank : 352)	NC score	0.675037 (rank : 73)
Query Neighborhood Hits	1103	Target Neighborhood Hits	779	Shared Neighborhood Hits	545
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ANKR6_HUMAN
θ value	0.000602161 (rank : 353)	NC score	0.417134 (rank : 762)
Query Neighborhood Hits	1103	Target Neighborhood Hits	439	Shared Neighborhood Hits	277
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

CD2A1_MOUSE
θ value	0.000602161 (rank : 354)	NC score	0.355607 (rank : 953)
Query Neighborhood Hits	1103	Target Neighborhood Hits	206	Shared Neighborhood Hits	188
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

KPCD1_HUMAN
θ value	0.000602161 (rank : 355)	NC score	0.490564 (rank : 459)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	562
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MYPT1_MOUSE
θ value	0.000602161 (rank : 356)	NC score	0.401104 (rank : 832)
Query Neighborhood Hits	1103	Target Neighborhood Hits	539	Shared Neighborhood Hits	291
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

VGFR1_MOUSE
θ value	0.000602161 (rank : 357)	NC score	0.610992 (rank : 207)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1118	Shared Neighborhood Hits	557
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

CDK4_HUMAN
θ value	0.000786445 (rank : 358)	NC score	0.492818 (rank : 451)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	562
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MIB2_HUMAN
θ value	0.000786445 (rank : 359)	NC score	0.386097 (rank : 898)
Query Neighborhood Hits	1103	Target Neighborhood Hits	438	Shared Neighborhood Hits	243
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

POT15_HUMAN
θ value	0.000786445 (rank : 360)	NC score	0.379548 (rank : 907)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	386
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

STK6_HUMAN
θ value	0.000786445 (rank : 361)	NC score	0.518162 (rank : 332)
Query Neighborhood Hits	1103	Target Neighborhood Hits	916	Shared Neighborhood Hits	578
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

TNKS2_HUMAN
θ value	0.000786445 (rank : 362)	NC score	0.409974 (rank : 793)
Query Neighborhood Hits	1103	Target Neighborhood Hits	361	Shared Neighborhood Hits	249
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ULK2_MOUSE
θ value	0.000786445 (rank : 363)	NC score	0.540108 (rank : 260)
Query Neighborhood Hits	1103	Target Neighborhood Hits	943	Shared Neighborhood Hits	582
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

FES_HUMAN
θ value	0.00102713 (rank : 364)	NC score	0.672417 (rank : 101)
Query Neighborhood Hits	1103	Target Neighborhood Hits	978	Shared Neighborhood Hits	579
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ICK_MOUSE
θ value	0.00102713 (rank : 365)	NC score	0.504204 (rank : 412)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	562
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MYLK_HUMAN
θ value	0.00102713 (rank : 366)	NC score	0.472509 (rank : 573)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1328	Shared Neighborhood Hits	586
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	0.00102713 (rank : 367)	NC score	0.471825 (rank : 576)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1489	Shared Neighborhood Hits	622
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NOTC4_MOUSE
θ value	0.00102713 (rank : 368)	NC score	0.216802 (rank : 1068)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	259
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

PHLB2_HUMAN
θ value	0.00102713 (rank : 369)	NC score	0.078006 (rank : 1237)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	172
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

TBK1_HUMAN
θ value	0.00102713 (rank : 370)	NC score	0.520267 (rank : 323)
Query Neighborhood Hits	1103	Target Neighborhood Hits	861	Shared Neighborhood Hits	566
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TNKS1_HUMAN
θ value	0.00102713 (rank : 371)	NC score	0.412455 (rank : 782)
Query Neighborhood Hits	1103	Target Neighborhood Hits	477	Shared Neighborhood Hits	274
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANKR5_HUMAN
θ value	0.00134147 (rank : 372)	NC score	0.400309 (rank : 835)
Query Neighborhood Hits	1103	Target Neighborhood Hits	297	Shared Neighborhood Hits	240
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANKR5_MOUSE
θ value	0.00134147 (rank : 373)	NC score	0.399499 (rank : 837)
Query Neighborhood Hits	1103	Target Neighborhood Hits	298	Shared Neighborhood Hits	243
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR18_HUMAN
θ value	0.00134147 (rank : 374)	NC score	0.323940 (rank : 994)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1106	Shared Neighborhood Hits	347
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR26_HUMAN
θ value	0.00134147 (rank : 375)	NC score	0.254578 (rank : 1051)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1614	Shared Neighborhood Hits	415
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ASB12_HUMAN
θ value	0.00134147 (rank : 376)	NC score	0.394979 (rank : 857)
Query Neighborhood Hits	1103	Target Neighborhood Hits	263	Shared Neighborhood Hits	233
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

CD2L6_HUMAN
θ value	0.00134147 (rank : 377)	NC score	0.457534 (rank : 642)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	549
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	0.00134147 (rank : 378)	NC score	0.457575 (rank : 641)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	554
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

DDR2_HUMAN
θ value	0.00134147 (rank : 379)	NC score	0.658220 (rank : 137)
Query Neighborhood Hits	1103	Target Neighborhood Hits	818	Shared Neighborhood Hits	552
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FES_MOUSE
θ value	0.00134147 (rank : 380)	NC score	0.673832 (rank : 86)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	588
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ICK_HUMAN
θ value	0.00134147 (rank : 381)	NC score	0.504270 (rank : 411)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	562
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

KPCD1_MOUSE
θ value	0.00134147 (rank : 382)	NC score	0.489395 (rank : 465)
Query Neighborhood Hits	1103	Target Neighborhood Hits	891	Shared Neighborhood Hits	563
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD3_HUMAN
θ value	0.00134147 (rank : 383)	NC score	0.488241 (rank : 473)
Query Neighborhood Hits	1103	Target Neighborhood Hits	895	Shared Neighborhood Hits	561
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
θ value	0.00134147 (rank : 384)	NC score	0.487795 (rank : 476)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	560
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

M3K3_HUMAN
θ value	0.00134147 (rank : 385)	NC score	0.537505 (rank : 269)
Query Neighborhood Hits	1103	Target Neighborhood Hits	885	Shared Neighborhood Hits	567
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MAK_HUMAN
θ value	0.00134147 (rank : 386)	NC score	0.502360 (rank : 420)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	560
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAPK3_MOUSE
θ value	0.00134147 (rank : 387)	NC score	0.467199 (rank : 596)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	542
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MPP8_HUMAN
θ value	0.00134147 (rank : 388)	NC score	0.354338 (rank : 957)
Query Neighborhood Hits	1103	Target Neighborhood Hits	948	Shared Neighborhood Hits	383
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

PP16A_HUMAN
θ value	0.00134147 (rank : 389)	NC score	0.392811 (rank : 871)
Query Neighborhood Hits	1103	Target Neighborhood Hits	340	Shared Neighborhood Hits	237
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

RIPK1_MOUSE
θ value	0.00134147 (rank : 390)	NC score	0.626583 (rank : 193)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	574
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

STK16_HUMAN
θ value	0.00134147 (rank : 391)	NC score	0.539313 (rank : 262)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	554
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK6_MOUSE
θ value	0.00134147 (rank : 392)	NC score	0.512570 (rank : 353)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	576
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TBK1_MOUSE
θ value	0.00134147 (rank : 393)	NC score	0.518977 (rank : 329)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	573
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

VGFR3_HUMAN
θ value	0.00134147 (rank : 394)	NC score	0.627572 (rank : 191)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1037	Shared Neighborhood Hits	558
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

ANKY2_HUMAN
θ value	0.00175202 (rank : 395)	NC score	0.375404 (rank : 919)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	229
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANRA2_MOUSE
θ value	0.00175202 (rank : 396)	NC score	0.399370 (rank : 838)
Query Neighborhood Hits	1103	Target Neighborhood Hits	287	Shared Neighborhood Hits	234
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ASZ1_MOUSE
θ value	0.00175202 (rank : 397)	NC score	0.401133 (rank : 831)
Query Neighborhood Hits	1103	Target Neighborhood Hits	319	Shared Neighborhood Hits	240
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

BCL3_HUMAN
θ value	0.00175202 (rank : 398)	NC score	0.402684 (rank : 822)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	243
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

CDK8_HUMAN
θ value	0.00175202 (rank : 399)	NC score	0.454185 (rank : 665)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	549
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CDN2D_MOUSE
θ value	0.00175202 (rank : 400)	NC score	0.402177 (rank : 823)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	235
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CLPB_HUMAN
θ value	0.00175202 (rank : 401)	NC score	0.312978 (rank : 1007)
Query Neighborhood Hits	1103	Target Neighborhood Hits	265	Shared Neighborhood Hits	203
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

E2AK3_HUMAN
θ value	0.00175202 (rank : 402)	NC score	0.529395 (rank : 287)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	565
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

IRAK4_HUMAN
θ value	0.00175202 (rank : 403)	NC score	0.612429 (rank : 205)
Query Neighborhood Hits	1103	Target Neighborhood Hits	816	Shared Neighborhood Hits	560
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

KS6A5_HUMAN
θ value	0.00175202 (rank : 404)	NC score	0.464294 (rank : 606)
Query Neighborhood Hits	1103	Target Neighborhood Hits	855	Shared Neighborhood Hits	569
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

NEK11_HUMAN
θ value	0.00175202 (rank : 405)	NC score	0.563104 (rank : 232)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1043	Shared Neighborhood Hits	608
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NIM1_HUMAN
θ value	0.00175202 (rank : 406)	NC score	0.514496 (rank : 346)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	567
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NOTC3_HUMAN
θ value	0.00175202 (rank : 407)	NC score	0.195477 (rank : 1089)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1062	Shared Neighborhood Hits	271
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	0.00175202 (rank : 408)	NC score	0.194554 (rank : 1090)
Query Neighborhood Hits	1103	Target Neighborhood Hits	975	Shared Neighborhood Hits	258
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC4_HUMAN
θ value	0.00175202 (rank : 409)	NC score	0.213117 (rank : 1071)
Query Neighborhood Hits	1103	Target Neighborhood Hits	905	Shared Neighborhood Hits	260
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

RFXK_MOUSE
θ value	0.00175202 (rank : 410)	NC score	0.400853 (rank : 833)
Query Neighborhood Hits	1103	Target Neighborhood Hits	273	Shared Neighborhood Hits	236
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

RIPK4_HUMAN
θ value	0.00175202 (rank : 411)	NC score	0.745769 (rank : 8)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1094	Shared Neighborhood Hits	783
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

TAOK1_HUMAN
θ value	0.00175202 (rank : 412)	NC score	0.529104 (rank : 289)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1734	Shared Neighborhood Hits	715
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TSSK6_HUMAN
θ value	0.00175202 (rank : 413)	NC score	0.499685 (rank : 428)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	558
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

VGFR3_MOUSE
θ value	0.00175202 (rank : 414)	NC score	0.625696 (rank : 195)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1056	Shared Neighborhood Hits	556
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

ASB11_MOUSE
θ value	0.00228821 (rank : 415)	NC score	0.398005 (rank : 843)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	228
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASZ1_HUMAN
θ value	0.00228821 (rank : 416)	NC score	0.401826 (rank : 826)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	238
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

CSKI1_HUMAN
θ value	0.00228821 (rank : 417)	NC score	0.413700 (rank : 773)
Query Neighborhood Hits	1103	Target Neighborhood Hits	997	Shared Neighborhood Hits	333
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	0.00228821 (rank : 418)	NC score	0.411879 (rank : 786)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1031	Shared Neighborhood Hits	340
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DMP1_HUMAN
θ value	0.00228821 (rank : 419)	NC score	0.100059 (rank : 1176)
Query Neighborhood Hits	1103	Target Neighborhood Hits	491	Shared Neighborhood Hits	136
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

GIT2_HUMAN
θ value	0.00228821 (rank : 420)	NC score	0.262540 (rank : 1044)
Query Neighborhood Hits	1103	Target Neighborhood Hits	381	Shared Neighborhood Hits	243
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

JAK3_HUMAN
θ value	0.00228821 (rank : 421)	NC score	0.649185 (rank : 156)
Query Neighborhood Hits	1103	Target Neighborhood Hits	827	Shared Neighborhood Hits	565
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

KCC1G_MOUSE
θ value	0.00228821 (rank : 422)	NC score	0.489035 (rank : 467)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	559
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MAPK3_HUMAN
θ value	0.00228821 (rank : 423)	NC score	0.455414 (rank : 657)
Query Neighborhood Hits	1103	Target Neighborhood Hits	807	Shared Neighborhood Hits	536
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MK03_MOUSE
θ value	0.00228821 (rank : 424)	NC score	0.482227 (rank : 505)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	559
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK09_HUMAN
θ value	0.00228821 (rank : 425)	NC score	0.460762 (rank : 624)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	564
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK13_HUMAN
θ value	0.00228821 (rank : 426)	NC score	0.472902 (rank : 570)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	558
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

OBSCN_HUMAN
θ value	0.00228821 (rank : 427)	NC score	0.429381 (rank : 725)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1931	Shared Neighborhood Hits	620
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PP16B_HUMAN
θ value	0.00228821 (rank : 428)	NC score	0.392642 (rank : 873)
Query Neighborhood Hits	1103	Target Neighborhood Hits	307	Shared Neighborhood Hits	244
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

ULK2_HUMAN
θ value	0.00228821 (rank : 429)	NC score	0.539254 (rank : 263)
Query Neighborhood Hits	1103	Target Neighborhood Hits	979	Shared Neighborhood Hits	588
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

VGFR2_HUMAN
θ value	0.00228821 (rank : 430)	NC score	0.610742 (rank : 208)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1103	Shared Neighborhood Hits	559
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	0.00228821 (rank : 431)	NC score	0.614112 (rank : 202)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1089	Shared Neighborhood Hits	558
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

ACBD6_HUMAN
θ value	0.00298849 (rank : 432)	NC score	0.386990 (rank : 893)
Query Neighborhood Hits	1103	Target Neighborhood Hits	304	Shared Neighborhood Hits	237
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ASB11_HUMAN
θ value	0.00298849 (rank : 433)	NC score	0.395323 (rank : 854)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	232
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

CD2L1_HUMAN
θ value	0.00298849 (rank : 434)	NC score	0.479928 (rank : 529)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1467	Shared Neighborhood Hits	669
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

E2AK3_MOUSE
θ value	0.00298849 (rank : 435)	NC score	0.528583 (rank : 294)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	562
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

GOGA4_MOUSE
θ value	0.00298849 (rank : 436)	NC score	0.072984 (rank : 1264)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1939	Shared Neighborhood Hits	257
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HECD1_HUMAN
θ value	0.00298849 (rank : 437)	NC score	0.299707 (rank : 1014)
Query Neighborhood Hits	1103	Target Neighborhood Hits	371	Shared Neighborhood Hits	238
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

IRAK4_MOUSE
θ value	0.00298849 (rank : 438)	NC score	0.603888 (rank : 213)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	563
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

KCC1G_HUMAN
θ value	0.00298849 (rank : 439)	NC score	0.488645 (rank : 471)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	560
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KS6A4_MOUSE
θ value	0.00298849 (rank : 440)	NC score	0.466367 (rank : 599)
Query Neighborhood Hits	1103	Target Neighborhood Hits	866	Shared Neighborhood Hits	571
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MK09_MOUSE
θ value	0.00298849 (rank : 441)	NC score	0.456160 (rank : 652)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	564
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

PP16B_MOUSE
θ value	0.00298849 (rank : 442)	NC score	0.391874 (rank : 876)
Query Neighborhood Hits	1103	Target Neighborhood Hits	302	Shared Neighborhood Hits	247
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

ROR2_MOUSE
θ value	0.00298849 (rank : 443)	NC score	0.653620 (rank : 149)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1000	Shared Neighborhood Hits	559
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

TIE1_HUMAN
θ value	0.00298849 (rank : 444)	NC score	0.638933 (rank : 173)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1241	Shared Neighborhood Hits	563
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

VGFR1_HUMAN
θ value	0.00298849 (rank : 445)	NC score	0.608538 (rank : 210)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1109	Shared Neighborhood Hits	557
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ZDH13_MOUSE
θ value	0.00298849 (rank : 446)	NC score	0.359203 (rank : 948)
Query Neighborhood Hits	1103	Target Neighborhood Hits	329	Shared Neighborhood Hits	237
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

BCL3_MOUSE
θ value	0.00390308 (rank : 447)	NC score	0.398350 (rank : 840)
Query Neighborhood Hits	1103	Target Neighborhood Hits	388	Shared Neighborhood Hits	249
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

GON4L_MOUSE
θ value	0.00390308 (rank : 448)	NC score	0.054366 (rank : 1512)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	85
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

KIT_HUMAN
θ value	0.00390308 (rank : 449)	NC score	0.646668 (rank : 160)
Query Neighborhood Hits	1103	Target Neighborhood Hits	953	Shared Neighborhood Hits	556
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	0.00390308 (rank : 450)	NC score	0.644367 (rank : 166)
Query Neighborhood Hits	1103	Target Neighborhood Hits	949	Shared Neighborhood Hits	556
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

M3K3_MOUSE
θ value	0.00390308 (rank : 451)	NC score	0.536142 (rank : 272)
Query Neighborhood Hits	1103	Target Neighborhood Hits	876	Shared Neighborhood Hits	567
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MK12_HUMAN
θ value	0.00390308 (rank : 452)	NC score	0.478781 (rank : 538)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	557
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	0.00390308 (rank : 453)	NC score	0.475960 (rank : 548)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	558
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MKNK2_HUMAN
θ value	0.00390308 (rank : 454)	NC score	0.439662 (rank : 705)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	550
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

NEK7_HUMAN
θ value	0.00390308 (rank : 455)	NC score	0.551021 (rank : 244)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	569
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

PCLO_HUMAN
θ value	0.00390308 (rank : 456)	NC score	0.065483 (rank : 1337)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2046	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TAOK3_MOUSE
θ value	0.00390308 (rank : 457)	NC score	0.529193 (rank : 288)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1458	Shared Neighborhood Hits	673
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TIE1_MOUSE
θ value	0.00390308 (rank : 458)	NC score	0.638258 (rank : 176)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1266	Shared Neighborhood Hits	566
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TSSK6_MOUSE
θ value	0.00390308 (rank : 459)	NC score	0.499326 (rank : 431)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	557
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ACBD6_MOUSE
θ value	0.00509761 (rank : 460)	NC score	0.389621 (rank : 884)
Query Neighborhood Hits	1103	Target Neighborhood Hits	305	Shared Neighborhood Hits	239
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANR29_HUMAN
θ value	0.00509761 (rank : 461)	NC score	0.420387 (rank : 746)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	237
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

AURKC_HUMAN
θ value	0.00509761 (rank : 462)	NC score	0.515273 (rank : 343)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	567
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

EP15_HUMAN
θ value	0.00509761 (rank : 463)	NC score	0.057299 (rank : 1457)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1021	Shared Neighborhood Hits	146
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

IWS1_MOUSE
θ value	0.00509761 (rank : 464)	NC score	0.089085 (rank : 1207)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1258	Shared Neighborhood Hits	232
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NEST_HUMAN
θ value	0.00509761 (rank : 465)	NC score	0.075948 (rank : 1247)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1305	Shared Neighborhood Hits	226
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

RYK_MOUSE
θ value	0.00509761 (rank : 466)	NC score	0.669806 (rank : 118)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	521
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

TRPA1_HUMAN
θ value	0.00509761 (rank : 467)	NC score	0.394290 (rank : 863)
Query Neighborhood Hits	1103	Target Neighborhood Hits	339	Shared Neighborhood Hits	238
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ULK3_HUMAN
θ value	0.00509761 (rank : 468)	NC score	0.529922 (rank : 285)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	559
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ANR10_HUMAN
θ value	0.00665767 (rank : 469)	NC score	0.397303 (rank : 846)
Query Neighborhood Hits	1103	Target Neighborhood Hits	289	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR21_HUMAN
θ value	0.00665767 (rank : 470)	NC score	0.374931 (rank : 920)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	383
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

CENPF_HUMAN
θ value	0.00665767 (rank : 471)	NC score	0.067449 (rank : 1313)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1932	Shared Neighborhood Hits	241
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

DGKZ_HUMAN
θ value	0.00665767 (rank : 472)	NC score	0.199422 (rank : 1085)
Query Neighborhood Hits	1103	Target Neighborhood Hits	551	Shared Neighborhood Hits	205
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

HUNK_HUMAN
θ value	0.00665767 (rank : 473)	NC score	0.510661 (rank : 373)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	573
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

IKKE_MOUSE
θ value	0.00665767 (rank : 474)	NC score	0.528856 (rank : 292)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	555
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MKNK2_MOUSE
θ value	0.00665767 (rank : 475)	NC score	0.433389 (rank : 716)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	549
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MYST3_HUMAN
θ value	0.00665767 (rank : 476)	NC score	0.055340 (rank : 1500)
Query Neighborhood Hits	1103	Target Neighborhood Hits	772	Shared Neighborhood Hits	129
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

NEK7_MOUSE
θ value	0.00665767 (rank : 477)	NC score	0.550790 (rank : 245)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	568
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NOTC2_HUMAN
θ value	0.00665767 (rank : 478)	NC score	0.193899 (rank : 1092)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1113	Shared Neighborhood Hits	294
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PCLO_MOUSE
θ value	0.00665767 (rank : 479)	NC score	0.054925 (rank : 1507)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2275	Shared Neighborhood Hits	246
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TAOK1_MOUSE
θ value	0.00665767 (rank : 480)	NC score	0.528386 (rank : 296)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1720	Shared Neighborhood Hits	713
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

AURKB_MOUSE
θ value	0.00869519 (rank : 481)	NC score	0.503974 (rank : 413)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	566
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

IKBA_HUMAN
θ value	0.00869519 (rank : 482)	NC score	0.383154 (rank : 903)
Query Neighborhood Hits	1103	Target Neighborhood Hits	280	Shared Neighborhood Hits	239
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

KPCG_HUMAN
θ value	0.00869519 (rank : 483)	NC score	0.459208 (rank : 629)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1126	Shared Neighborhood Hits	566
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	0.00869519 (rank : 484)	NC score	0.459464 (rank : 628)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1123	Shared Neighborhood Hits	566
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6A4_HUMAN
θ value	0.00869519 (rank : 485)	NC score	0.465270 (rank : 604)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	573
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

MK03_HUMAN
θ value	0.00869519 (rank : 486)	NC score	0.482038 (rank : 506)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	558
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

NOP14_MOUSE
θ value	0.00869519 (rank : 487)	NC score	0.055196 (rank : 1502)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R3N1	Gene names	Nop14
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

TCF8_HUMAN
θ value	0.00869519 (rank : 488)	NC score	-0.011902 (rank : 1790)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1057	Shared Neighborhood Hits	82
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

WEE1B_MOUSE
θ value	0.00869519 (rank : 489)	NC score	0.442730 (rank : 698)
Query Neighborhood Hits	1103	Target Neighborhood Hits	765	Shared Neighborhood Hits	513
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WNK1_HUMAN
θ value	0.00869519 (rank : 490)	NC score	0.521946 (rank : 316)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1158	Shared Neighborhood Hits	574
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	0.00869519 (rank : 491)	NC score	0.521008 (rank : 320)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1179	Shared Neighborhood Hits	577
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

ANPRB_MOUSE
θ value	0.0113563 (rank : 492)	NC score	0.514642 (rank : 344)
Query Neighborhood Hits	1103	Target Neighborhood Hits	607	Shared Neighborhood Hits	428
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANR10_MOUSE
θ value	0.0113563 (rank : 493)	NC score	0.395117 (rank : 856)
Query Neighborhood Hits	1103	Target Neighborhood Hits	273	Shared Neighborhood Hits	227
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ARAF_MOUSE
θ value	0.0113563 (rank : 494)	NC score	0.636097 (rank : 179)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	568
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ASB4_MOUSE
θ value	0.0113563 (rank : 495)	NC score	0.386306 (rank : 897)
Query Neighborhood Hits	1103	Target Neighborhood Hits	265	Shared Neighborhood Hits	230
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB7_HUMAN
θ value	0.0113563 (rank : 496)	NC score	0.408214 (rank : 802)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
θ value	0.0113563 (rank : 497)	NC score	0.408833 (rank : 801)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	238
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB9_HUMAN
θ value	0.0113563 (rank : 498)	NC score	0.395819 (rank : 851)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	228
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

CD2L2_HUMAN
θ value	0.0113563 (rank : 499)	NC score	0.479322 (rank : 534)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1439	Shared Neighborhood Hits	669
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CYLC1_HUMAN
θ value	0.0113563 (rank : 500)	NC score	0.092874 (rank : 1193)
Query Neighborhood Hits	1103	Target Neighborhood Hits	408	Shared Neighborhood Hits	93
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

DSPP_HUMAN
θ value	0.0113563 (rank : 501)	NC score	0.069345 (rank : 1297)
Query Neighborhood Hits	1103	Target Neighborhood Hits	645	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

GABP3_MOUSE
θ value	0.0113563 (rank : 502)	NC score	0.408101 (rank : 804)
Query Neighborhood Hits	1103	Target Neighborhood Hits	330	Shared Neighborhood Hits	247
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

HUNK_MOUSE
θ value	0.0113563 (rank : 503)	NC score	0.510072 (rank : 378)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	569
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

KPCE_MOUSE
θ value	0.0113563 (rank : 504)	NC score	0.462697 (rank : 610)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	559
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MUSK_HUMAN
θ value	0.0113563 (rank : 505)	NC score	0.618519 (rank : 198)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1074	Shared Neighborhood Hits	554
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

RSF1_HUMAN
θ value	0.0113563 (rank : 506)	NC score	0.085314 (rank : 1214)
Query Neighborhood Hits	1103	Target Neighborhood Hits	539	Shared Neighborhood Hits	120
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

TRPA1_MOUSE
θ value	0.0113563 (rank : 507)	NC score	0.394156 (rank : 864)
Query Neighborhood Hits	1103	Target Neighborhood Hits	343	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

USH1G_HUMAN
θ value	0.0113563 (rank : 508)	NC score	0.372443 (rank : 926)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	228
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	0.0113563 (rank : 509)	NC score	0.372578 (rank : 925)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	228
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANPRB_HUMAN
θ value	0.0148317 (rank : 510)	NC score	0.525313 (rank : 306)
Query Neighborhood Hits	1103	Target Neighborhood Hits	646	Shared Neighborhood Hits	441
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

AP3B1_HUMAN
θ value	0.0148317 (rank : 511)	NC score	0.040245 (rank : 1635)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	53
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ARI4A_HUMAN
θ value	0.0148317 (rank : 512)	NC score	0.090824 (rank : 1203)
Query Neighborhood Hits	1103	Target Neighborhood Hits	434	Shared Neighborhood Hits	102
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

ASPP2_HUMAN
θ value	0.0148317 (rank : 513)	NC score	0.319498 (rank : 1000)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1156	Shared Neighborhood Hits	371
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

DGKI_HUMAN
θ value	0.0148317 (rank : 514)	NC score	0.189841 (rank : 1098)
Query Neighborhood Hits	1103	Target Neighborhood Hits	609	Shared Neighborhood Hits	200
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

EHMT1_HUMAN
θ value	0.0148317 (rank : 515)	NC score	0.377800 (rank : 912)
Query Neighborhood Hits	1103	Target Neighborhood Hits	417	Shared Neighborhood Hits	262
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

KCC1A_HUMAN
θ value	0.0148317 (rank : 516)	NC score	0.486428 (rank : 483)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	564
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	0.0148317 (rank : 517)	NC score	0.486087 (rank : 486)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	564
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1D_HUMAN
θ value	0.0148317 (rank : 518)	NC score	0.481232 (rank : 516)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	561
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	0.0148317 (rank : 519)	NC score	0.481260 (rank : 515)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	561
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KPCE_HUMAN
θ value	0.0148317 (rank : 520)	NC score	0.461812 (rank : 619)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	559
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KS6A5_MOUSE
θ value	0.0148317 (rank : 521)	NC score	0.458410 (rank : 635)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	568
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MARK4_HUMAN
θ value	0.0148317 (rank : 522)	NC score	0.510932 (rank : 371)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	577
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	0.0148317 (rank : 523)	NC score	0.510961 (rank : 369)
Query Neighborhood Hits	1103	Target Neighborhood Hits	898	Shared Neighborhood Hits	577
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

NEK1_HUMAN
θ value	0.0148317 (rank : 524)	NC score	0.532979 (rank : 277)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1129	Shared Neighborhood Hits	633
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	0.0148317 (rank : 525)	NC score	0.538936 (rank : 265)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1311	Shared Neighborhood Hits	697
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK6_HUMAN
θ value	0.0148317 (rank : 526)	NC score	0.545595 (rank : 250)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	568
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NFKB1_HUMAN
θ value	0.0148317 (rank : 527)	NC score	0.335023 (rank : 980)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	236
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NOTC1_HUMAN
θ value	0.0148317 (rank : 528)	NC score	0.190953 (rank : 1096)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	262
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

REST_MOUSE
θ value	0.0148317 (rank : 529)	NC score	0.063660 (rank : 1354)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1506	Shared Neighborhood Hits	208
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RYK_HUMAN
θ value	0.0148317 (rank : 530)	NC score	0.668080 (rank : 121)
Query Neighborhood Hits	1103	Target Neighborhood Hits	701	Shared Neighborhood Hits	515
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

AN36B_HUMAN
θ value	0.0193708 (rank : 531)	NC score	0.389114 (rank : 888)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	238
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

BARD1_MOUSE
θ value	0.0193708 (rank : 532)	NC score	0.375909 (rank : 916)
Query Neighborhood Hits	1103	Target Neighborhood Hits	411	Shared Neighborhood Hits	244
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BAZ2B_HUMAN
θ value	0.0193708 (rank : 533)	NC score	0.052839 (rank : 1546)
Query Neighborhood Hits	1103	Target Neighborhood Hits	803	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CHK2_MOUSE
θ value	0.0193708 (rank : 534)	NC score	0.472124 (rank : 574)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

LIMK2_HUMAN
θ value	0.0193708 (rank : 535)	NC score	0.599023 (rank : 217)
Query Neighborhood Hits	1103	Target Neighborhood Hits	986	Shared Neighborhood Hits	568
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	0.0193708 (rank : 536)	NC score	0.597498 (rank : 218)
Query Neighborhood Hits	1103	Target Neighborhood Hits	998	Shared Neighborhood Hits	570
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

M3K8_MOUSE
θ value	0.0193708 (rank : 537)	NC score	0.504502 (rank : 409)
Query Neighborhood Hits	1103	Target Neighborhood Hits	815	Shared Neighborhood Hits	550
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MAST1_HUMAN
θ value	0.0193708 (rank : 538)	NC score	0.444258 (rank : 695)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1146	Shared Neighborhood Hits	589
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0.0193708 (rank : 539)	NC score	0.443917 (rank : 697)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1123	Shared Neighborhood Hits	587
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST3_HUMAN
θ value	0.0193708 (rank : 540)	NC score	0.450089 (rank : 677)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1128	Shared Neighborhood Hits	594
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	0.0193708 (rank : 541)	NC score	0.451806 (rank : 673)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1804	Shared Neighborhood Hits	665
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MELK_HUMAN
θ value	0.0193708 (rank : 542)	NC score	0.496167 (rank : 440)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	567
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MK10_HUMAN
θ value	0.0193708 (rank : 543)	NC score	0.461845 (rank : 618)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	561
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK13_MOUSE
θ value	0.0193708 (rank : 544)	NC score	0.471021 (rank : 582)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MOS_HUMAN
θ value	0.0193708 (rank : 545)	NC score	0.624997 (rank : 196)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	566
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

NEK11_MOUSE
θ value	0.0193708 (rank : 546)	NC score	0.562258 (rank : 233)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	569
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK6_MOUSE
θ value	0.0193708 (rank : 547)	NC score	0.545374 (rank : 251)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	568
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

PHLB2_MOUSE
θ value	0.0193708 (rank : 548)	NC score	0.078224 (rank : 1236)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1016	Shared Neighborhood Hits	188
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PRKX_MOUSE
θ value	0.0193708 (rank : 549)	NC score	0.481972 (rank : 509)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	565
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

RBM5_HUMAN
θ value	0.0193708 (rank : 550)	NC score	0.032001 (rank : 1658)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	16
SwissProt Accessions	P52756, Q93021, Q9BU14, Q9UKY8, Q9UL24	Gene names	RBM5
Domain Architecture
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15) (Protein G15) (NY-REN-9 antigen).

ARAF_HUMAN
θ value	0.0252991 (rank : 551)	NC score	0.634322 (rank : 182)
Query Neighborhood Hits	1103	Target Neighborhood Hits	924	Shared Neighborhood Hits	576
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ASB5_MOUSE
θ value	0.0252991 (rank : 552)	NC score	0.388480 (rank : 889)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

BARD1_HUMAN
θ value	0.0252991 (rank : 553)	NC score	0.374562 (rank : 921)
Query Neighborhood Hits	1103	Target Neighborhood Hits	427	Shared Neighborhood Hits	245
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

DCAK1_HUMAN
θ value	0.0252991 (rank : 554)	NC score	0.481398 (rank : 513)
Query Neighborhood Hits	1103	Target Neighborhood Hits	877	Shared Neighborhood Hits	568
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	0.0252991 (rank : 555)	NC score	0.480850 (rank : 522)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	563
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KPCI_HUMAN
θ value	0.0252991 (rank : 556)	NC score	0.449235 (rank : 681)
Query Neighborhood Hits	1103	Target Neighborhood Hits	885	Shared Neighborhood Hits	566
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	0.0252991 (rank : 557)	NC score	0.448592 (rank : 686)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	566
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

LEO1_HUMAN
θ value	0.0252991 (rank : 558)	NC score	0.091927 (rank : 1197)
Query Neighborhood Hits	1103	Target Neighborhood Hits	958	Shared Neighborhood Hits	213
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

M3K4_MOUSE
θ value	0.0252991 (rank : 559)	NC score	0.516760 (rank : 338)
Query Neighborhood Hits	1103	Target Neighborhood Hits	924	Shared Neighborhood Hits	580
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

MELK_MOUSE
θ value	0.0252991 (rank : 560)	NC score	0.494658 (rank : 445)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	564
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

NEK2_MOUSE
θ value	0.0252991 (rank : 561)	NC score	0.522881 (rank : 314)
Query Neighborhood Hits	1103	Target Neighborhood Hits	876	Shared Neighborhood Hits	576
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NFKB2_MOUSE
θ value	0.0252991 (rank : 562)	NC score	0.334639 (rank : 981)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	240
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

PCNT_HUMAN
θ value	0.0252991 (rank : 563)	NC score	0.069070 (rank : 1298)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1551	Shared Neighborhood Hits	218
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PDPK1_MOUSE
θ value	0.0252991 (rank : 564)	NC score	0.490632 (rank : 458)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	561
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

R51A1_MOUSE
θ value	0.0252991 (rank : 565)	NC score	0.053753 (rank : 1529)
Query Neighborhood Hits	1103	Target Neighborhood Hits	164	Shared Neighborhood Hits	54
SwissProt Accessions	Q8C551, O55219, Q8BP36, Q99L94, Q9D0J0	Gene names	Rad51ap1
Domain Architecture	No domain graphic available
Description	RAD51-associated protein 1 (RAD51-interacting protein) (RAB22).

RIF1_HUMAN
θ value	0.0252991 (rank : 566)	NC score	0.061611 (rank : 1388)
Query Neighborhood Hits	1103	Target Neighborhood Hits	320	Shared Neighborhood Hits	91
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

STK3_MOUSE
θ value	0.0252991 (rank : 567)	NC score	0.542945 (rank : 258)
Query Neighborhood Hits	1103	Target Neighborhood Hits	869	Shared Neighborhood Hits	573
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	0.0252991 (rank : 568)	NC score	0.544499 (rank : 255)
Query Neighborhood Hits	1103	Target Neighborhood Hits	870	Shared Neighborhood Hits	572
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	0.0252991 (rank : 569)	NC score	0.544787 (rank : 253)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	575
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

TAOK2_MOUSE
θ value	0.0252991 (rank : 570)	NC score	0.536555 (rank : 271)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1373	Shared Neighborhood Hits	651
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

WNK4_MOUSE
θ value	0.0252991 (rank : 571)	NC score	0.510955 (rank : 370)
Query Neighborhood Hits	1103	Target Neighborhood Hits	961	Shared Neighborhood Hits	544
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ASB16_HUMAN
θ value	0.0330416 (rank : 572)	NC score	0.389850 (rank : 883)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	237
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ASB5_HUMAN
θ value	0.0330416 (rank : 573)	NC score	0.390213 (rank : 881)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	235
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

CENB2_HUMAN
θ value	0.0330416 (rank : 574)	NC score	0.262109 (rank : 1045)
Query Neighborhood Hits	1103	Target Neighborhood Hits	425	Shared Neighborhood Hits	238
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

DGKZ_MOUSE
θ value	0.0330416 (rank : 575)	NC score	0.190513 (rank : 1097)
Query Neighborhood Hits	1103	Target Neighborhood Hits	542	Shared Neighborhood Hits	194
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

GOGB1_HUMAN
θ value	0.0330416 (rank : 576)	NC score	0.076782 (rank : 1243)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2297	Shared Neighborhood Hits	291
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

IKBA_MOUSE
θ value	0.0330416 (rank : 577)	NC score	0.377770 (rank : 913)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

M3K4_HUMAN
θ value	0.0330416 (rank : 578)	NC score	0.517533 (rank : 334)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	577
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

MK08_HUMAN
θ value	0.0330416 (rank : 579)	NC score	0.456482 (rank : 650)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	559
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	0.0330416 (rank : 580)	NC score	0.456805 (rank : 647)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	559
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

NOTC2_MOUSE
θ value	0.0330416 (rank : 581)	NC score	0.187988 (rank : 1100)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1069	Shared Neighborhood Hits	266
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PDPK1_HUMAN
θ value	0.0330416 (rank : 582)	NC score	0.490183 (rank : 461)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	561
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

RBM5_MOUSE
θ value	0.0330416 (rank : 583)	NC score	0.031863 (rank : 1659)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	19
SwissProt Accessions	Q91YE7, Q3UZ19, Q99KV9	Gene names	Rbm5, Luca15
Domain Architecture	No domain graphic available
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15).

STK3_HUMAN
θ value	0.0330416 (rank : 584)	NC score	0.542158 (rank : 259)
Query Neighborhood Hits	1103	Target Neighborhood Hits	861	Shared Neighborhood Hits	571
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

TRHY_HUMAN
θ value	0.0330416 (rank : 585)	NC score	0.068051 (rank : 1307)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1385	Shared Neighborhood Hits	184
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

YTDC1_HUMAN
θ value	0.0330416 (rank : 586)	NC score	0.068178 (rank : 1305)
Query Neighborhood Hits	1103	Target Neighborhood Hits	458	Shared Neighborhood Hits	115
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZDH13_HUMAN
θ value	0.0330416 (rank : 587)	NC score	0.358862 (rank : 949)
Query Neighborhood Hits	1103	Target Neighborhood Hits	322	Shared Neighborhood Hits	235
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ANR25_MOUSE
θ value	0.0431538 (rank : 588)	NC score	0.313877 (rank : 1005)
Query Neighborhood Hits	1103	Target Neighborhood Hits	398	Shared Neighborhood Hits	242
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANS4B_HUMAN
θ value	0.0431538 (rank : 589)	NC score	0.368047 (rank : 931)
Query Neighborhood Hits	1103	Target Neighborhood Hits	289	Shared Neighborhood Hits	228
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

DAPK3_MOUSE
θ value	0.0431538 (rank : 590)	NC score	0.506680 (rank : 396)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	557
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

EHMT2_MOUSE
θ value	0.0431538 (rank : 591)	NC score	0.364782 (rank : 941)
Query Neighborhood Hits	1103	Target Neighborhood Hits	750	Shared Neighborhood Hits	299
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EP15_MOUSE
θ value	0.0431538 (rank : 592)	NC score	0.055069 (rank : 1504)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	109
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP300_HUMAN
θ value	0.0431538 (rank : 593)	NC score	0.035109 (rank : 1653)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	98
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

KPCA_MOUSE
θ value	0.0431538 (rank : 594)	NC score	0.474896 (rank : 555)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1067	Shared Neighborhood Hits	559
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KS6A1_MOUSE
θ value	0.0431538 (rank : 595)	NC score	0.491284 (rank : 457)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	570
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

M3K14_MOUSE
θ value	0.0431538 (rank : 596)	NC score	0.481301 (rank : 514)
Query Neighborhood Hits	1103	Target Neighborhood Hits	889	Shared Neighborhood Hits	548
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MAP1B_MOUSE
θ value	0.0431538 (rank : 597)	NC score	0.081438 (rank : 1223)
Query Neighborhood Hits	1103	Target Neighborhood Hits	977	Shared Neighborhood Hits	186
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MINT_MOUSE
θ value	0.0431538 (rank : 598)	NC score	0.055230 (rank : 1501)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1514	Shared Neighborhood Hits	216
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MUSK_MOUSE
θ value	0.0431538 (rank : 599)	NC score	0.618192 (rank : 200)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1057	Shared Neighborhood Hits	553
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PLK4_MOUSE
θ value	0.0431538 (rank : 600)	NC score	0.512566 (rank : 354)
Query Neighborhood Hits	1103	Target Neighborhood Hits	879	Shared Neighborhood Hits	571
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

TAOK2_HUMAN
θ value	0.0431538 (rank : 601)	NC score	0.539621 (rank : 261)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1172	Shared Neighborhood Hits	631
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

WDR43_HUMAN
θ value	0.0431538 (rank : 602)	NC score	0.027587 (rank : 1675)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	28
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

ANR46_MOUSE
θ value	0.0563607 (rank : 603)	NC score	0.395388 (rank : 853)
Query Neighborhood Hits	1103	Target Neighborhood Hits	274	Shared Neighborhood Hits	236
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

DYNA_HUMAN
θ value	0.0563607 (rank : 604)	NC score	0.062180 (rank : 1378)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1194	Shared Neighborhood Hits	182
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	0.0563607 (rank : 605)	NC score	0.060861 (rank : 1395)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1084	Shared Neighborhood Hits	160
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

K1383_HUMAN
θ value	0.0563607 (rank : 606)	NC score	0.051275 (rank : 1574)
Query Neighborhood Hits	1103	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2G4, Q58EZ9, Q5VV83	Gene names	KIAA1383
Domain Architecture	No domain graphic available
Description	Protein KIAA1383.

KCC4_MOUSE
θ value	0.0563607 (rank : 607)	NC score	0.471871 (rank : 575)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	575
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KPCA_HUMAN
θ value	0.0563607 (rank : 608)	NC score	0.471471 (rank : 579)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1070	Shared Neighborhood Hits	562
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

LEO1_MOUSE
θ value	0.0563607 (rank : 609)	NC score	0.087464 (rank : 1211)
Query Neighborhood Hits	1103	Target Neighborhood Hits	946	Shared Neighborhood Hits	208
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MK10_MOUSE
θ value	0.0563607 (rank : 610)	NC score	0.461135 (rank : 623)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	561
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MYLK2_HUMAN
θ value	0.0563607 (rank : 611)	NC score	0.524152 (rank : 309)
Query Neighborhood Hits	1103	Target Neighborhood Hits	920	Shared Neighborhood Hits	563
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK2_HUMAN
θ value	0.0563607 (rank : 612)	NC score	0.529977 (rank : 284)
Query Neighborhood Hits	1103	Target Neighborhood Hits	908	Shared Neighborhood Hits	580
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

RN5A_HUMAN
θ value	0.0563607 (rank : 613)	NC score	0.450639 (rank : 675)
Query Neighborhood Hits	1103	Target Neighborhood Hits	608	Shared Neighborhood Hits	438
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

STK10_HUMAN
θ value	0.0563607 (rank : 614)	NC score	0.520078 (rank : 324)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1921	Shared Neighborhood Hits	722
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	0.0563607 (rank : 615)	NC score	0.511252 (rank : 364)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2132	Shared Neighborhood Hits	754
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK36_HUMAN
θ value	0.0563607 (rank : 616)	NC score	0.518252 (rank : 331)
Query Neighborhood Hits	1103	Target Neighborhood Hits	896	Shared Neighborhood Hits	571
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ACINU_MOUSE
θ value	0.0736092 (rank : 617)	NC score	0.074984 (rank : 1252)
Query Neighborhood Hits	1103	Target Neighborhood Hits	712	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ANR15_HUMAN
θ value	0.0736092 (rank : 618)	NC score	0.340783 (rank : 972)
Query Neighborhood Hits	1103	Target Neighborhood Hits	478	Shared Neighborhood Hits	273
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ASB10_HUMAN
θ value	0.0736092 (rank : 619)	NC score	0.405428 (rank : 815)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	243
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ASPP1_HUMAN
θ value	0.0736092 (rank : 620)	NC score	0.313242 (rank : 1006)
Query Neighborhood Hits	1103	Target Neighborhood Hits	956	Shared Neighborhood Hits	347
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	0.0736092 (rank : 621)	NC score	0.305834 (rank : 1011)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1244	Shared Neighborhood Hits	390
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

AURKC_MOUSE
θ value	0.0736092 (rank : 622)	NC score	0.512072 (rank : 357)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	565
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

E2AK2_MOUSE
θ value	0.0736092 (rank : 623)	NC score	0.538075 (rank : 267)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	563
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

HDAC5_HUMAN
θ value	0.0736092 (rank : 624)	NC score	0.028034 (rank : 1674)
Query Neighborhood Hits	1103	Target Neighborhood Hits	353	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

KAPCG_HUMAN
θ value	0.0736092 (rank : 625)	NC score	0.473520 (rank : 564)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	564
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

LRRK1_MOUSE
θ value	0.0736092 (rank : 626)	NC score	0.591675 (rank : 219)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1267	Shared Neighborhood Hits	668
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

M3K8_HUMAN
θ value	0.0736092 (rank : 627)	NC score	0.506501 (rank : 398)
Query Neighborhood Hits	1103	Target Neighborhood Hits	807	Shared Neighborhood Hits	548
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

PLK1_MOUSE
θ value	0.0736092 (rank : 628)	NC score	0.500463 (rank : 426)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	566
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

WNK4_HUMAN
θ value	0.0736092 (rank : 629)	NC score	0.508476 (rank : 387)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1043	Shared Neighborhood Hits	558
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ANS4B_MOUSE
θ value	0.0961366 (rank : 630)	NC score	0.363410 (rank : 944)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	229
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASB9_MOUSE
θ value	0.0961366 (rank : 631)	NC score	0.388351 (rank : 890)
Query Neighborhood Hits	1103	Target Neighborhood Hits	257	Shared Neighborhood Hits	224
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

CDK10_HUMAN
θ value	0.0961366 (rank : 632)	NC score	0.479145 (rank : 535)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	559
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CENPE_HUMAN
θ value	0.0961366 (rank : 633)	NC score	0.060846 (rank : 1396)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2060	Shared Neighborhood Hits	255
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CT086_HUMAN
θ value	0.0961366 (rank : 634)	NC score	0.401513 (rank : 830)
Query Neighborhood Hits	1103	Target Neighborhood Hits	277	Shared Neighborhood Hits	235
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

DAPK2_MOUSE
θ value	0.0961366 (rank : 635)	NC score	0.502126 (rank : 421)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	560
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	0.0961366 (rank : 636)	NC score	0.505835 (rank : 402)
Query Neighborhood Hits	1103	Target Neighborhood Hits	945	Shared Neighborhood Hits	579
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KPCL_MOUSE
θ value	0.0961366 (rank : 637)	NC score	0.456006 (rank : 653)
Query Neighborhood Hits	1103	Target Neighborhood Hits	891	Shared Neighborhood Hits	555
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

LRRK1_HUMAN
θ value	0.0961366 (rank : 638)	NC score	0.578042 (rank : 223)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1237	Shared Neighborhood Hits	642
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

M3K14_HUMAN
θ value	0.0961366 (rank : 639)	NC score	0.496609 (rank : 438)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	561
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

MAP1B_HUMAN
θ value	0.0961366 (rank : 640)	NC score	0.076232 (rank : 1246)
Query Neighborhood Hits	1103	Target Neighborhood Hits	903	Shared Neighborhood Hits	161
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MARK1_HUMAN
θ value	0.0961366 (rank : 641)	NC score	0.510246 (rank : 377)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	576
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MK01_HUMAN
θ value	0.0961366 (rank : 642)	NC score	0.480149 (rank : 526)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	555
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	0.0961366 (rank : 643)	NC score	0.480471 (rank : 524)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	555
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

PLK4_HUMAN
θ value	0.0961366 (rank : 644)	NC score	0.511370 (rank : 359)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	569
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PRKX_HUMAN
θ value	0.0961366 (rank : 645)	NC score	0.480121 (rank : 527)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	566
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

RFXK_HUMAN
θ value	0.0961366 (rank : 646)	NC score	0.394863 (rank : 858)
Query Neighborhood Hits	1103	Target Neighborhood Hits	282	Shared Neighborhood Hits	233
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

SLK_HUMAN
θ value	0.0961366 (rank : 647)	NC score	0.521846 (rank : 317)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1775	Shared Neighborhood Hits	708
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

ZCHC6_MOUSE
θ value	0.0961366 (rank : 648)	NC score	0.020439 (rank : 1708)
Query Neighborhood Hits	1103	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q5BLK4, Q8CIH3	Gene names	Zcchc6
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

ANR47_MOUSE
θ value	0.125558 (rank : 649)	NC score	0.340611 (rank : 973)
Query Neighborhood Hits	1103	Target Neighborhood Hits	350	Shared Neighborhood Hits	244
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB10_MOUSE
θ value	0.125558 (rank : 650)	NC score	0.402848 (rank : 821)
Query Neighborhood Hits	1103	Target Neighborhood Hits	301	Shared Neighborhood Hits	243
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

CENPC_HUMAN
θ value	0.125558 (rank : 651)	NC score	0.045398 (rank : 1616)
Query Neighborhood Hits	1103	Target Neighborhood Hits	147	Shared Neighborhood Hits	51
SwissProt Accessions	Q03188, Q9P0M5	Gene names	CENPC1, CENPC, ICEN7
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C) (Interphase centromere complex protein 7).

CHK2_HUMAN
θ value	0.125558 (rank : 652)	NC score	0.466189 (rank : 600)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	559
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

DAPK2_HUMAN
θ value	0.125558 (rank : 653)	NC score	0.495353 (rank : 443)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	557
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

EHMT2_HUMAN
θ value	0.125558 (rank : 654)	NC score	0.368562 (rank : 927)
Query Neighborhood Hits	1103	Target Neighborhood Hits	498	Shared Neighborhood Hits	266
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

LRCH2_HUMAN
θ value	0.125558 (rank : 655)	NC score	0.016064 (rank : 1729)
Query Neighborhood Hits	1103	Target Neighborhood Hits	315	Shared Neighborhood Hits	23
SwissProt Accessions	Q5VUJ6, Q9HA88, Q9P233	Gene names	LRCH2, KIAA1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

MASTL_HUMAN
θ value	0.125558 (rank : 656)	NC score	0.472663 (rank : 572)
Query Neighborhood Hits	1103	Target Neighborhood Hits	894	Shared Neighborhood Hits	569
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PLK1_HUMAN
θ value	0.125558 (rank : 657)	NC score	0.509029 (rank : 385)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	567
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_MOUSE
θ value	0.125558 (rank : 658)	NC score	0.511039 (rank : 367)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	566
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

RTN1_HUMAN
θ value	0.125558 (rank : 659)	NC score	0.024959 (rank : 1684)
Query Neighborhood Hits	1103	Target Neighborhood Hits	173	Shared Neighborhood Hits	29
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

WNK3_HUMAN
θ value	0.125558 (rank : 660)	NC score	0.513271 (rank : 351)
Query Neighborhood Hits	1103	Target Neighborhood Hits	948	Shared Neighborhood Hits	552
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

ANKZ1_MOUSE
θ value	0.163984 (rank : 661)	NC score	0.184900 (rank : 1103)
Query Neighborhood Hits	1103	Target Neighborhood Hits	208	Shared Neighborhood Hits	145
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ANR37_HUMAN
θ value	0.163984 (rank : 662)	NC score	0.348072 (rank : 964)
Query Neighborhood Hits	1103	Target Neighborhood Hits	247	Shared Neighborhood Hits	222
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

AURKB_HUMAN
θ value	0.163984 (rank : 663)	NC score	0.505959 (rank : 400)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	565
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

BCOR_HUMAN
θ value	0.163984 (rank : 664)	NC score	0.336963 (rank : 977)
Query Neighborhood Hits	1103	Target Neighborhood Hits	609	Shared Neighborhood Hits	291
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

BCOR_MOUSE
θ value	0.163984 (rank : 665)	NC score	0.339667 (rank : 974)
Query Neighborhood Hits	1103	Target Neighborhood Hits	521	Shared Neighborhood Hits	276
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CD2L1_MOUSE
θ value	0.163984 (rank : 666)	NC score	0.479057 (rank : 536)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1463	Shared Neighborhood Hits	669
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CLSPN_HUMAN
θ value	0.163984 (rank : 667)	NC score	0.057201 (rank : 1460)
Query Neighborhood Hits	1103	Target Neighborhood Hits	433	Shared Neighborhood Hits	102
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

CSKI2_HUMAN
θ value	0.163984 (rank : 668)	NC score	0.405954 (rank : 812)
Query Neighborhood Hits	1103	Target Neighborhood Hits	747	Shared Neighborhood Hits	304
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

KCC1B_MOUSE
θ value	0.163984 (rank : 669)	NC score	0.484546 (rank : 491)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KPCD_HUMAN
θ value	0.163984 (rank : 670)	NC score	0.487658 (rank : 477)
Query Neighborhood Hits	1103	Target Neighborhood Hits	900	Shared Neighborhood Hits	562
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	0.163984 (rank : 671)	NC score	0.488723 (rank : 469)
Query Neighborhood Hits	1103	Target Neighborhood Hits	897	Shared Neighborhood Hits	564
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MARK2_HUMAN
θ value	0.163984 (rank : 672)	NC score	0.509719 (rank : 381)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1056	Shared Neighborhood Hits	608
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MK11_HUMAN
θ value	0.163984 (rank : 673)	NC score	0.471486 (rank : 578)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	553
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MYH10_HUMAN
θ value	0.163984 (rank : 674)	NC score	0.048642 (rank : 1607)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1620	Shared Neighborhood Hits	210
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PLK2_HUMAN
θ value	0.163984 (rank : 675)	NC score	0.510863 (rank : 372)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	566
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ST17B_MOUSE
θ value	0.163984 (rank : 676)	NC score	0.504888 (rank : 407)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	560
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

TAOK3_HUMAN
θ value	0.163984 (rank : 677)	NC score	0.528159 (rank : 297)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1494	Shared Neighborhood Hits	680
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

ANKZ1_HUMAN
θ value	0.21417 (rank : 678)	NC score	0.182780 (rank : 1105)
Query Neighborhood Hits	1103	Target Neighborhood Hits	236	Shared Neighborhood Hits	158
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

ANR16_HUMAN
θ value	0.21417 (rank : 679)	NC score	0.408180 (rank : 803)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	238
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ASB6_HUMAN
θ value	0.21417 (rank : 680)	NC score	0.355815 (rank : 952)
Query Neighborhood Hits	1103	Target Neighborhood Hits	256	Shared Neighborhood Hits	225
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

CDKL3_MOUSE
θ value	0.21417 (rank : 681)	NC score	0.482696 (rank : 502)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	562
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CSKI2_MOUSE
θ value	0.21417 (rank : 682)	NC score	0.405842 (rank : 813)
Query Neighborhood Hits	1103	Target Neighborhood Hits	812	Shared Neighborhood Hits	314
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

E2AK1_HUMAN
θ value	0.21417 (rank : 683)	NC score	0.522888 (rank : 313)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	555
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

LAD1_HUMAN
θ value	0.21417 (rank : 684)	NC score	0.054143 (rank : 1520)
Query Neighborhood Hits	1103	Target Neighborhood Hits	441	Shared Neighborhood Hits	97
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

MAPK2_HUMAN
θ value	0.21417 (rank : 685)	NC score	0.463060 (rank : 609)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	557
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	0.21417 (rank : 686)	NC score	0.461360 (rank : 622)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	555
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MARK1_MOUSE
θ value	0.21417 (rank : 687)	NC score	0.509098 (rank : 384)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	575
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK3_MOUSE
θ value	0.21417 (rank : 688)	NC score	0.509760 (rank : 379)
Query Neighborhood Hits	1103	Target Neighborhood Hits	919	Shared Neighborhood Hits	579
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MYH10_MOUSE
θ value	0.21417 (rank : 689)	NC score	0.047429 (rank : 1612)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1612	Shared Neighborhood Hits	209
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH9_HUMAN
θ value	0.21417 (rank : 690)	NC score	0.052229 (rank : 1557)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1762	Shared Neighborhood Hits	233
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NFYC_HUMAN
θ value	0.21417 (rank : 691)	NC score	0.022689 (rank : 1693)
Query Neighborhood Hits	1103	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q13952, Q5T6K8, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7	Gene names	NFYC
Domain Architecture
Description	Nuclear transcription factor Y subunit gamma (Nuclear transcription factor Y subunit C) (NF-YC) (CAAT-box DNA-binding protein subunit C) (Transactivator HSM-1/2).

NKTR_HUMAN
θ value	0.21417 (rank : 692)	NC score	0.037452 (rank : 1644)
Query Neighborhood Hits	1103	Target Neighborhood Hits	658	Shared Neighborhood Hits	150
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

POT14_HUMAN
θ value	0.21417 (rank : 693)	NC score	0.351853 (rank : 963)
Query Neighborhood Hits	1103	Target Neighborhood Hits	403	Shared Neighborhood Hits	277
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

RENT2_HUMAN
θ value	0.21417 (rank : 694)	NC score	0.072077 (rank : 1272)
Query Neighborhood Hits	1103	Target Neighborhood Hits	618	Shared Neighborhood Hits	120
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

SCYL2_MOUSE
θ value	0.21417 (rank : 695)	NC score	0.347323 (rank : 965)
Query Neighborhood Hits	1103	Target Neighborhood Hits	603	Shared Neighborhood Hits	413
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ANR45_HUMAN
θ value	0.279714 (rank : 696)	NC score	0.281860 (rank : 1026)
Query Neighborhood Hits	1103	Target Neighborhood Hits	201	Shared Neighborhood Hits	171
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

BRD2_HUMAN
θ value	0.279714 (rank : 697)	NC score	0.021734 (rank : 1700)
Query Neighborhood Hits	1103	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

CCD82_HUMAN
θ value	0.279714 (rank : 698)	NC score	0.048562 (rank : 1608)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N4S0, Q9H2Q5, Q9H5E3	Gene names	CCDC82
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 82.

DMRTA_MOUSE
θ value	0.279714 (rank : 699)	NC score	0.021095 (rank : 1703)
Query Neighborhood Hits	1103	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFG4	Gene names	Dmrta1, Dmrt4
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor A1 (Doublesex- and mab-3-related transcription factor 4).

FA44A_HUMAN
θ value	0.279714 (rank : 700)	NC score	0.055358 (rank : 1498)
Query Neighborhood Hits	1103	Target Neighborhood Hits	280	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

IKBB_MOUSE
θ value	0.279714 (rank : 701)	NC score	0.367518 (rank : 934)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	238
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

KCC1B_HUMAN
θ value	0.279714 (rank : 702)	NC score	0.483810 (rank : 494)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

MK11_MOUSE
θ value	0.279714 (rank : 703)	NC score	0.465745 (rank : 602)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	556
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MYH11_HUMAN
θ value	0.279714 (rank : 704)	NC score	0.049567 (rank : 1600)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1806	Shared Neighborhood Hits	234
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYST4_HUMAN
θ value	0.279714 (rank : 705)	NC score	0.045035 (rank : 1618)
Query Neighborhood Hits	1103	Target Neighborhood Hits	671	Shared Neighborhood Hits	132
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NUMA1_HUMAN
θ value	0.279714 (rank : 706)	NC score	0.058888 (rank : 1430)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1523	Shared Neighborhood Hits	192
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RP1L1_HUMAN
θ value	0.279714 (rank : 707)	NC score	0.053214 (rank : 1540)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1072	Shared Neighborhood Hits	164
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SLK_MOUSE
θ value	0.279714 (rank : 708)	NC score	0.521221 (rank : 318)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1798	Shared Neighborhood Hits	717
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

TOPRS_HUMAN
θ value	0.279714 (rank : 709)	NC score	0.020566 (rank : 1707)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

ANR25_HUMAN
θ value	0.365318 (rank : 710)	NC score	0.314746 (rank : 1004)
Query Neighborhood Hits	1103	Target Neighborhood Hits	350	Shared Neighborhood Hits	233
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ANR45_MOUSE
θ value	0.365318 (rank : 711)	NC score	0.294766 (rank : 1018)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	176
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ASB6_MOUSE
θ value	0.365318 (rank : 712)	NC score	0.353440 (rank : 960)
Query Neighborhood Hits	1103	Target Neighborhood Hits	264	Shared Neighborhood Hits	221
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

CCD96_MOUSE
θ value	0.365318 (rank : 713)	NC score	0.076285 (rank : 1245)
Query Neighborhood Hits	1103	Target Neighborhood Hits	704	Shared Neighborhood Hits	164
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CENB5_HUMAN
θ value	0.365318 (rank : 714)	NC score	0.262611 (rank : 1043)
Query Neighborhood Hits	1103	Target Neighborhood Hits	395	Shared Neighborhood Hits	242
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG2_HUMAN
θ value	0.365318 (rank : 715)	NC score	0.168925 (rank : 1110)
Query Neighborhood Hits	1103	Target Neighborhood Hits	471	Shared Neighborhood Hits	231
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

E2AK2_HUMAN
θ value	0.365318 (rank : 716)	NC score	0.537554 (rank : 268)
Query Neighborhood Hits	1103	Target Neighborhood Hits	856	Shared Neighborhood Hits	560
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

GOGA4_HUMAN
θ value	0.365318 (rank : 717)	NC score	0.071358 (rank : 1282)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2034	Shared Neighborhood Hits	244
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

IKKA_MOUSE
θ value	0.365318 (rank : 718)	NC score	0.544510 (rank : 254)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	568
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IRAK1_HUMAN
θ value	0.365318 (rank : 719)	NC score	0.591317 (rank : 220)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	547
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

KPCL_HUMAN
θ value	0.365318 (rank : 720)	NC score	0.452486 (rank : 672)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	555
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_MOUSE
θ value	0.365318 (rank : 721)	NC score	0.486217 (rank : 485)
Query Neighborhood Hits	1103	Target Neighborhood Hits	895	Shared Neighborhood Hits	562
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCZ_MOUSE
θ value	0.365318 (rank : 722)	NC score	0.438183 (rank : 710)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	565
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MARK2_MOUSE
θ value	0.365318 (rank : 723)	NC score	0.505584 (rank : 403)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1018	Shared Neighborhood Hits	605
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MASTL_MOUSE
θ value	0.365318 (rank : 724)	NC score	0.475105 (rank : 553)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	564
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MK14_HUMAN
θ value	0.365318 (rank : 725)	NC score	0.475033 (rank : 554)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	561
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	0.365318 (rank : 726)	NC score	0.473956 (rank : 562)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	561
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

NEK8_HUMAN
θ value	0.365318 (rank : 727)	NC score	0.516289 (rank : 339)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	564
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	0.365318 (rank : 728)	NC score	0.515656 (rank : 342)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	565
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NFKB2_HUMAN
θ value	0.365318 (rank : 729)	NC score	0.337774 (rank : 976)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	240
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

RHG25_HUMAN
θ value	0.365318 (rank : 730)	NC score	0.029566 (rank : 1666)
Query Neighborhood Hits	1103	Target Neighborhood Hits	550	Shared Neighborhood Hits	93
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RIPK5_MOUSE
θ value	0.365318 (rank : 731)	NC score	0.577019 (rank : 224)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	574
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

SCYL2_HUMAN
θ value	0.365318 (rank : 732)	NC score	0.357270 (rank : 950)
Query Neighborhood Hits	1103	Target Neighborhood Hits	632	Shared Neighborhood Hits	438
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SGK2_HUMAN
θ value	0.365318 (rank : 733)	NC score	0.460484 (rank : 626)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	560
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

TAF3_HUMAN
θ value	0.365318 (rank : 734)	NC score	0.055747 (rank : 1490)
Query Neighborhood Hits	1103	Target Neighborhood Hits	568	Shared Neighborhood Hits	110
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

ACINU_HUMAN
θ value	0.47712 (rank : 735)	NC score	0.073800 (rank : 1258)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	190
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BAT2_MOUSE
θ value	0.47712 (rank : 736)	NC score	0.032497 (rank : 1657)
Query Neighborhood Hits	1103	Target Neighborhood Hits	947	Shared Neighborhood Hits	106
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CCAR1_HUMAN
θ value	0.47712 (rank : 737)	NC score	0.052223 (rank : 1558)
Query Neighborhood Hits	1103	Target Neighborhood Hits	444	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

CT116_MOUSE
θ value	0.47712 (rank : 738)	NC score	0.044101 (rank : 1624)
Query Neighborhood Hits	1103	Target Neighborhood Hits	268	Shared Neighborhood Hits	56
SwissProt Accessions	Q80WW9, Q9CT52	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 homolog precursor.

DCAK3_HUMAN
θ value	0.47712 (rank : 739)	NC score	0.478203 (rank : 539)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	575
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DMPK_MOUSE
θ value	0.47712 (rank : 740)	NC score	0.404584 (rank : 818)
Query Neighborhood Hits	1103	Target Neighborhood Hits	908	Shared Neighborhood Hits	561
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

FBX38_HUMAN
θ value	0.47712 (rank : 741)	NC score	0.028051 (rank : 1673)
Query Neighborhood Hits	1103	Target Neighborhood Hits	141	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PIJ6, Q6PK72, Q7Z2U0, Q86VN3, Q9BXY6, Q9H837, Q9HC40	Gene names	FBXO38
Domain Architecture	No domain graphic available
Description	F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA).

IF3A_HUMAN
θ value	0.47712 (rank : 742)	NC score	0.056337 (rank : 1478)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	143
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

KPCZ_HUMAN
θ value	0.47712 (rank : 743)	NC score	0.437960 (rank : 711)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	565
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

M3K1_MOUSE
θ value	0.47712 (rank : 744)	NC score	0.529894 (rank : 286)
Query Neighborhood Hits	1103	Target Neighborhood Hits	952	Shared Neighborhood Hits	577
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MARK3_HUMAN
θ value	0.47712 (rank : 745)	NC score	0.508183 (rank : 389)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	575
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MCES_HUMAN
θ value	0.47712 (rank : 746)	NC score	0.025901 (rank : 1680)
Query Neighborhood Hits	1103	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

MYH11_MOUSE
θ value	0.47712 (rank : 747)	NC score	0.049834 (rank : 1598)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1777	Shared Neighborhood Hits	226
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NOTC1_MOUSE
θ value	0.47712 (rank : 748)	NC score	0.158793 (rank : 1119)
Query Neighborhood Hits	1103	Target Neighborhood Hits	916	Shared Neighborhood Hits	248
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NSBP1_MOUSE
θ value	0.47712 (rank : 749)	NC score	0.066304 (rank : 1324)
Query Neighborhood Hits	1103	Target Neighborhood Hits	681	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

RIPK5_HUMAN
θ value	0.47712 (rank : 750)	NC score	0.576940 (rank : 225)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	574
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

STK36_MOUSE
θ value	0.47712 (rank : 751)	NC score	0.521160 (rank : 319)
Query Neighborhood Hits	1103	Target Neighborhood Hits	877	Shared Neighborhood Hits	571
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

TXD13_HUMAN
θ value	0.47712 (rank : 752)	NC score	0.022859 (rank : 1692)
Query Neighborhood Hits	1103	Target Neighborhood Hits	106	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H1E5, Q8N4P7, Q8NCC1, Q9UJA1, Q9ULQ8	Gene names	TXNDC13, KIAA1162
Domain Architecture
Description	Thioredoxin domain-containing protein 13 precursor.

WNK2_HUMAN
θ value	0.47712 (rank : 753)	NC score	0.510268 (rank : 376)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1407	Shared Neighborhood Hits	588
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ANR46_HUMAN
θ value	0.62314 (rank : 754)	NC score	0.388113 (rank : 891)
Query Neighborhood Hits	1103	Target Neighborhood Hits	281	Shared Neighborhood Hits	237
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR49_HUMAN
θ value	0.62314 (rank : 755)	NC score	0.393899 (rank : 865)
Query Neighborhood Hits	1103	Target Neighborhood Hits	282	Shared Neighborhood Hits	235
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

CDKL3_HUMAN
θ value	0.62314 (rank : 756)	NC score	0.485267 (rank : 489)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	564
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CENG2_MOUSE
θ value	0.62314 (rank : 757)	NC score	0.167315 (rank : 1113)
Query Neighborhood Hits	1103	Target Neighborhood Hits	463	Shared Neighborhood Hits	227
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

GUC2C_HUMAN
θ value	0.62314 (rank : 758)	NC score	0.570392 (rank : 227)
Query Neighborhood Hits	1103	Target Neighborhood Hits	624	Shared Neighborhood Hits	468
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

HDAC5_MOUSE
θ value	0.62314 (rank : 759)	NC score	0.022023 (rank : 1698)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

IKKA_HUMAN
θ value	0.62314 (rank : 760)	NC score	0.546112 (rank : 249)
Query Neighborhood Hits	1103	Target Neighborhood Hits	863	Shared Neighborhood Hits	565
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KCC2B_HUMAN
θ value	0.62314 (rank : 761)	NC score	0.456671 (rank : 648)
Query Neighborhood Hits	1103	Target Neighborhood Hits	866	Shared Neighborhood Hits	556
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	0.62314 (rank : 762)	NC score	0.454763 (rank : 662)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	554
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

LRCH2_MOUSE
θ value	0.62314 (rank : 763)	NC score	0.011224 (rank : 1747)
Query Neighborhood Hits	1103	Target Neighborhood Hits	287	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UMG5, Q7TNP9, Q80TC9	Gene names	Lrch2, Kiaa1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

NFM_HUMAN
θ value	0.62314 (rank : 764)	NC score	0.042542 (rank : 1629)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1328	Shared Neighborhood Hits	223
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PESC_HUMAN
θ value	0.62314 (rank : 765)	NC score	0.022211 (rank : 1696)
Query Neighborhood Hits	1103	Target Neighborhood Hits	90	Shared Neighborhood Hits	24
SwissProt Accessions	O00541, Q6IC29	Gene names	PES1
Domain Architecture
Description	Pescadillo homolog 1.

PRG4_HUMAN
θ value	0.62314 (rank : 766)	NC score	0.031538 (rank : 1660)
Query Neighborhood Hits	1103	Target Neighborhood Hits	764	Shared Neighborhood Hits	98
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SAS6_HUMAN
θ value	0.62314 (rank : 767)	NC score	0.064253 (rank : 1349)
Query Neighborhood Hits	1103	Target Neighborhood Hits	791	Shared Neighborhood Hits	129
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

STK33_HUMAN
θ value	0.62314 (rank : 768)	NC score	0.519608 (rank : 326)
Query Neighborhood Hits	1103	Target Neighborhood Hits	879	Shared Neighborhood Hits	572
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

AN13A_HUMAN
θ value	0.813845 (rank : 769)	NC score	0.208019 (rank : 1078)
Query Neighborhood Hits	1103	Target Neighborhood Hits	243	Shared Neighborhood Hits	196
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

ANKR7_HUMAN
θ value	0.813845 (rank : 770)	NC score	0.392436 (rank : 874)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	238
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANPRA_HUMAN
θ value	0.813845 (rank : 771)	NC score	0.528089 (rank : 298)
Query Neighborhood Hits	1103	Target Neighborhood Hits	612	Shared Neighborhood Hits	433
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	0.813845 (rank : 772)	NC score	0.524182 (rank : 308)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	422
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ATRX_HUMAN
θ value	0.813845 (rank : 773)	NC score	0.049184 (rank : 1603)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	166
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

BPA1_MOUSE
θ value	0.813845 (rank : 774)	NC score	0.041257 (rank : 1632)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1477	Shared Neighborhood Hits	191
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

PRKY_HUMAN
θ value	0.813845 (rank : 775)	NC score	0.493580 (rank : 447)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	566
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

SAS6_MOUSE
θ value	0.813845 (rank : 776)	NC score	0.061742 (rank : 1383)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	147
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SBK1_MOUSE
θ value	0.813845 (rank : 777)	NC score	0.484624 (rank : 490)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	544
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SFR12_MOUSE
θ value	0.813845 (rank : 778)	NC score	0.057668 (rank : 1445)
Query Neighborhood Hits	1103	Target Neighborhood Hits	486	Shared Neighborhood Hits	98
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

SRCH_HUMAN
θ value	0.813845 (rank : 779)	NC score	0.050004 (rank : 1596)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

ST17B_HUMAN
θ value	0.813845 (rank : 780)	NC score	0.494227 (rank : 446)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	556
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

AN32B_MOUSE
θ value	1.06291 (rank : 781)	NC score	0.022610 (rank : 1694)
Query Neighborhood Hits	1103	Target Neighborhood Hits	236	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

CENG3_HUMAN
θ value	1.06291 (rank : 782)	NC score	0.154048 (rank : 1122)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	214
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	1.06291 (rank : 783)	NC score	0.153559 (rank : 1123)
Query Neighborhood Hits	1103	Target Neighborhood Hits	467	Shared Neighborhood Hits	214
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CTRO_HUMAN
θ value	1.06291 (rank : 784)	NC score	0.415830 (rank : 767)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2092	Shared Neighborhood Hits	713
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CYLC2_HUMAN
θ value	1.06291 (rank : 785)	NC score	0.059530 (rank : 1413)
Query Neighborhood Hits	1103	Target Neighborhood Hits	223	Shared Neighborhood Hits	52
SwissProt Accessions	Q14093	Gene names	CYLC2, CYL2
Domain Architecture	No domain graphic available
Description	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).

DCAK2_HUMAN
θ value	1.06291 (rank : 786)	NC score	0.471349 (rank : 580)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	557
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	1.06291 (rank : 787)	NC score	0.473767 (rank : 563)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	559
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

GCC2_MOUSE
θ value	1.06291 (rank : 788)	NC score	0.065828 (rank : 1330)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1619	Shared Neighborhood Hits	221
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

ICAL_MOUSE
θ value	1.06291 (rank : 789)	NC score	0.033794 (rank : 1655)
Query Neighborhood Hits	1103	Target Neighborhood Hits	178	Shared Neighborhood Hits	45
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

IKBB_HUMAN
θ value	1.06291 (rank : 790)	NC score	0.363333 (rank : 945)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	237
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

KAPCA_MOUSE
θ value	1.06291 (rank : 791)	NC score	0.462081 (rank : 614)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	558
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KCC4_HUMAN
θ value	1.06291 (rank : 792)	NC score	0.473184 (rank : 568)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	558
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KPCD_MOUSE
θ value	1.06291 (rank : 793)	NC score	0.481695 (rank : 511)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	562
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MPP10_MOUSE
θ value	1.06291 (rank : 794)	NC score	0.057215 (rank : 1458)
Query Neighborhood Hits	1103	Target Neighborhood Hits	251	Shared Neighborhood Hits	67
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MYH9_MOUSE
θ value	1.06291 (rank : 795)	NC score	0.052466 (rank : 1554)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1829	Shared Neighborhood Hits	237
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NACAM_MOUSE
θ value	1.06291 (rank : 796)	NC score	0.045353 (rank : 1617)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1866	Shared Neighborhood Hits	199
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCOR2_MOUSE
θ value	1.06291 (rank : 797)	NC score	0.049589 (rank : 1599)
Query Neighborhood Hits	1103	Target Neighborhood Hits	790	Shared Neighborhood Hits	151
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NFL_MOUSE
θ value	1.06291 (rank : 798)	NC score	0.022406 (rank : 1695)
Query Neighborhood Hits	1103	Target Neighborhood Hits	695	Shared Neighborhood Hits	127
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

PGFRA_HUMAN
θ value	1.06291 (rank : 799)	NC score	0.633177 (rank : 186)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	558
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	1.06291 (rank : 800)	NC score	0.633661 (rank : 183)
Query Neighborhood Hits	1103	Target Neighborhood Hits	975	Shared Neighborhood Hits	558
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ROCK1_HUMAN
θ value	1.06291 (rank : 801)	NC score	0.411425 (rank : 788)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2000	Shared Neighborhood Hits	705
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	1.06291 (rank : 802)	NC score	0.405552 (rank : 814)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2126	Shared Neighborhood Hits	718
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

SEC62_HUMAN
θ value	1.06291 (rank : 803)	NC score	0.030470 (rank : 1662)
Query Neighborhood Hits	1103	Target Neighborhood Hits	100	Shared Neighborhood Hits	23
SwissProt Accessions	Q99442, O00682, O00729	Gene names	TLOC1, SEC62
Domain Architecture	No domain graphic available
Description	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1).

SRRM2_HUMAN
θ value	1.06291 (rank : 804)	NC score	0.056610 (rank : 1474)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1296	Shared Neighborhood Hits	167
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ST32C_HUMAN
θ value	1.06291 (rank : 805)	NC score	0.454401 (rank : 663)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

TCOF_HUMAN
θ value	1.06291 (rank : 806)	NC score	0.037060 (rank : 1647)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TNIK_HUMAN
θ value	1.06291 (rank : 807)	NC score	0.511294 (rank : 362)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1570	Shared Neighborhood Hits	667
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

XRCC1_HUMAN
θ value	1.06291 (rank : 808)	NC score	0.029816 (rank : 1665)
Query Neighborhood Hits	1103	Target Neighborhood Hits	131	Shared Neighborhood Hits	44
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

ANKY1_HUMAN
θ value	1.38821 (rank : 809)	NC score	0.265084 (rank : 1041)
Query Neighborhood Hits	1103	Target Neighborhood Hits	248	Shared Neighborhood Hits	190
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

ANR37_MOUSE
θ value	1.38821 (rank : 810)	NC score	0.334579 (rank : 982)
Query Neighborhood Hits	1103	Target Neighborhood Hits	237	Shared Neighborhood Hits	213
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR47_HUMAN
θ value	1.38821 (rank : 811)	NC score	0.323347 (rank : 995)
Query Neighborhood Hits	1103	Target Neighborhood Hits	369	Shared Neighborhood Hits	238
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ANR49_MOUSE
θ value	1.38821 (rank : 812)	NC score	0.392793 (rank : 872)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	236
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

BPAEA_MOUSE
θ value	1.38821 (rank : 813)	NC score	0.062186 (rank : 1377)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1480	Shared Neighborhood Hits	214
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CAF1A_MOUSE
θ value	1.38821 (rank : 814)	NC score	0.056325 (rank : 1479)
Query Neighborhood Hits	1103	Target Neighborhood Hits	736	Shared Neighborhood Hits	130
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CNGA1_HUMAN
θ value	1.38821 (rank : 815)	NC score	0.014602 (rank : 1737)
Query Neighborhood Hits	1103	Target Neighborhood Hits	149	Shared Neighborhood Hits	31
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

COG2_HUMAN
θ value	1.38821 (rank : 816)	NC score	0.013565 (rank : 1741)
Query Neighborhood Hits	1103	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q14746	Gene names	COG2, LDLC
Domain Architecture
Description	Conserved oligomeric Golgi complex component 2 (Low density lipoprotein receptor defect C-complementing protein).

CTRO_MOUSE
θ value	1.38821 (rank : 817)	NC score	0.409296 (rank : 799)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2344	Shared Neighborhood Hits	742
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CYTSA_HUMAN
θ value	1.38821 (rank : 818)	NC score	0.049476 (rank : 1602)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1138	Shared Neighborhood Hits	186
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
θ value	1.38821 (rank : 819)	NC score	0.048725 (rank : 1606)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1104	Shared Neighborhood Hits	181
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DMPK_HUMAN
θ value	1.38821 (rank : 820)	NC score	0.402159 (rank : 824)
Query Neighborhood Hits	1103	Target Neighborhood Hits	944	Shared Neighborhood Hits	567
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

E2AK1_MOUSE
θ value	1.38821 (rank : 821)	NC score	0.511369 (rank : 360)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	550
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

GON4L_HUMAN
θ value	1.38821 (rank : 822)	NC score	0.042782 (rank : 1628)
Query Neighborhood Hits	1103	Target Neighborhood Hits	555	Shared Neighborhood Hits	111
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

INVO_HUMAN
θ value	1.38821 (rank : 823)	NC score	0.062022 (rank : 1381)
Query Neighborhood Hits	1103	Target Neighborhood Hits	636	Shared Neighborhood Hits	119
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

IRAK1_MOUSE
θ value	1.38821 (rank : 824)	NC score	0.590182 (rank : 221)
Query Neighborhood Hits	1103	Target Neighborhood Hits	784	Shared Neighborhood Hits	534
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IWS1_HUMAN
θ value	1.38821 (rank : 825)	NC score	0.090926 (rank : 1201)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1241	Shared Neighborhood Hits	242
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K0408_HUMAN
θ value	1.38821 (rank : 826)	NC score	0.028071 (rank : 1672)
Query Neighborhood Hits	1103	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZU52, O43158, Q5TF20, Q7L2M2	Gene names	KIAA0408
Domain Architecture	No domain graphic available
Description	Protein KIAA0408.

KAPCA_HUMAN
θ value	1.38821 (rank : 827)	NC score	0.461730 (rank : 621)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	560
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	1.38821 (rank : 828)	NC score	0.462555 (rank : 613)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	560
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

LRRF1_MOUSE
θ value	1.38821 (rank : 829)	NC score	0.049901 (rank : 1597)
Query Neighborhood Hits	1103	Target Neighborhood Hits	440	Shared Neighborhood Hits	122
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

M3K15_HUMAN
θ value	1.38821 (rank : 830)	NC score	0.525739 (rank : 303)
Query Neighborhood Hits	1103	Target Neighborhood Hits	914	Shared Neighborhood Hits	575
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M4K4_HUMAN
θ value	1.38821 (rank : 831)	NC score	0.502573 (rank : 418)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1589	Shared Neighborhood Hits	666
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	1.38821 (rank : 832)	NC score	0.514035 (rank : 349)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1560	Shared Neighborhood Hits	664
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MDN1_HUMAN
θ value	1.38821 (rank : 833)	NC score	0.069634 (rank : 1293)
Query Neighborhood Hits	1103	Target Neighborhood Hits	662	Shared Neighborhood Hits	165
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

MYH14_MOUSE
θ value	1.38821 (rank : 834)	NC score	0.045771 (rank : 1615)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1225	Shared Neighborhood Hits	172
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

NCOA7_MOUSE
θ value	1.38821 (rank : 835)	NC score	0.018922 (rank : 1718)
Query Neighborhood Hits	1103	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

PCNT_MOUSE
θ value	1.38821 (rank : 836)	NC score	0.059248 (rank : 1421)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1207	Shared Neighborhood Hits	167
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PELP1_MOUSE
θ value	1.38821 (rank : 837)	NC score	0.035638 (rank : 1652)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	106
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PHKG1_HUMAN
θ value	1.38821 (rank : 838)	NC score	0.448827 (rank : 682)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	562
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TGFR1_HUMAN
θ value	1.38821 (rank : 839)	NC score	0.492602 (rank : 453)
Query Neighborhood Hits	1103	Target Neighborhood Hits	755	Shared Neighborhood Hits	545
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	1.38821 (rank : 840)	NC score	0.492765 (rank : 452)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	545
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TOIP2_HUMAN
θ value	1.38821 (rank : 841)	NC score	0.020688 (rank : 1706)
Query Neighborhood Hits	1103	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NFQ8	Gene names	TOR1AIP2, LULL1
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1).

TR150_HUMAN
θ value	1.38821 (rank : 842)	NC score	0.039743 (rank : 1638)
Query Neighborhood Hits	1103	Target Neighborhood Hits	313	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TRPV6_MOUSE
θ value	1.38821 (rank : 843)	NC score	0.246207 (rank : 1057)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	220
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

ZFP91_HUMAN
θ value	1.38821 (rank : 844)	NC score	-0.018785 (rank : 1792)
Query Neighborhood Hits	1103	Target Neighborhood Hits	769	Shared Neighborhood Hits	26
SwissProt Accessions	Q96JP5, Q86V47, Q96JP4, Q96QA3	Gene names	ZFP91
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 homolog (Zfp-91).

AN32E_HUMAN
θ value	1.81305 (rank : 845)	NC score	0.016803 (rank : 1728)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

AP3B2_HUMAN
θ value	1.81305 (rank : 846)	NC score	0.026121 (rank : 1678)
Query Neighborhood Hits	1103	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

ASB16_MOUSE
θ value	1.81305 (rank : 847)	NC score	0.385831 (rank : 899)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	241
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

BICD2_MOUSE
θ value	1.81305 (rank : 848)	NC score	0.050587 (rank : 1588)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	138
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BPAEA_HUMAN
θ value	1.81305 (rank : 849)	NC score	0.044771 (rank : 1619)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1369	Shared Neighborhood Hits	181
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CCD46_MOUSE
θ value	1.81305 (rank : 850)	NC score	0.069767 (rank : 1292)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1405	Shared Neighborhood Hits	215
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CENB1_HUMAN
θ value	1.81305 (rank : 851)	NC score	0.257324 (rank : 1048)
Query Neighborhood Hits	1103	Target Neighborhood Hits	383	Shared Neighborhood Hits	236
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CKAP4_MOUSE
θ value	1.81305 (rank : 852)	NC score	0.042969 (rank : 1627)
Query Neighborhood Hits	1103	Target Neighborhood Hits	596	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CT116_HUMAN
θ value	1.81305 (rank : 853)	NC score	0.044275 (rank : 1623)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	64
SwissProt Accessions	Q96HY6, Q9BW47	Gene names	C20orf116
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 precursor.

HRX_HUMAN
θ value	1.81305 (rank : 854)	NC score	0.024787 (rank : 1685)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	111
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

HS90A_MOUSE
θ value	1.81305 (rank : 855)	NC score	0.015358 (rank : 1735)
Query Neighborhood Hits	1103	Target Neighborhood Hits	155	Shared Neighborhood Hits	37
SwissProt Accessions	P07901	Gene names	Hsp90aa1, Hsp86, Hsp86-1, Hspca
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (Tumor-specific transplantation 86 kDa antigen) (TSTA).

HTSF1_HUMAN
θ value	1.81305 (rank : 856)	NC score	0.047301 (rank : 1613)
Query Neighborhood Hits	1103	Target Neighborhood Hits	408	Shared Neighborhood Hits	83
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

IASPP_HUMAN
θ value	1.81305 (rank : 857)	NC score	0.320116 (rank : 998)
Query Neighborhood Hits	1103	Target Neighborhood Hits	688	Shared Neighborhood Hits	292
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKBL_HUMAN
θ value	1.81305 (rank : 858)	NC score	0.169806 (rank : 1109)
Query Neighborhood Hits	1103	Target Neighborhood Hits	168	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

MAP2_HUMAN
θ value	1.81305 (rank : 859)	NC score	0.025992 (rank : 1679)
Query Neighborhood Hits	1103	Target Neighborhood Hits	348	Shared Neighborhood Hits	78
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MINK1_HUMAN
θ value	1.81305 (rank : 860)	NC score	0.511344 (rank : 361)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1477	Shared Neighborhood Hits	656
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	1.81305 (rank : 861)	NC score	0.511836 (rank : 358)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1451	Shared Neighborhood Hits	660
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK07_MOUSE
θ value	1.81305 (rank : 862)	NC score	0.474006 (rank : 560)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1054	Shared Neighborhood Hits	581
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MORC1_HUMAN
θ value	1.81305 (rank : 863)	NC score	0.017952 (rank : 1723)
Query Neighborhood Hits	1103	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q86VD1, Q7L8E2, Q9NSG7, Q9Y6D4	Gene names	MORC1, MORC
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 1.

MTPN_HUMAN
θ value	1.81305 (rank : 864)	NC score	0.389165 (rank : 887)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	228
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

MTPN_MOUSE
θ value	1.81305 (rank : 865)	NC score	0.390220 (rank : 880)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	228
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

MYO3A_MOUSE
θ value	1.81305 (rank : 866)	NC score	0.453622 (rank : 669)
Query Neighborhood Hits	1103	Target Neighborhood Hits	902	Shared Neighborhood Hits	578
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO6_HUMAN
θ value	1.81305 (rank : 867)	NC score	0.032849 (rank : 1656)
Query Neighborhood Hits	1103	Target Neighborhood Hits	727	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

NEK9_HUMAN
θ value	1.81305 (rank : 868)	NC score	0.520283 (rank : 321)
Query Neighborhood Hits	1103	Target Neighborhood Hits	900	Shared Neighborhood Hits	572
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	1.81305 (rank : 869)	NC score	0.518742 (rank : 330)
Query Neighborhood Hits	1103	Target Neighborhood Hits	890	Shared Neighborhood Hits	572
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NFKB1_MOUSE
θ value	1.81305 (rank : 870)	NC score	0.332572 (rank : 987)
Query Neighborhood Hits	1103	Target Neighborhood Hits	300	Shared Neighborhood Hits	234
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

NPBL_MOUSE
θ value	1.81305 (rank : 871)	NC score	0.065332 (rank : 1340)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1041	Shared Neighborhood Hits	224
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

NTKL_MOUSE
θ value	1.81305 (rank : 872)	NC score	0.198094 (rank : 1087)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	217
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

PARD3_HUMAN
θ value	1.81305 (rank : 873)	NC score	0.013840 (rank : 1740)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PODXL_HUMAN
θ value	1.81305 (rank : 874)	NC score	0.017486 (rank : 1725)
Query Neighborhood Hits	1103	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	O00592	Gene names	PODXL, PCLP, PCLP1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

TCF8_MOUSE
θ value	1.81305 (rank : 875)	NC score	-0.012912 (rank : 1791)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1067	Shared Neighborhood Hits	83
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

TITIN_HUMAN
θ value	1.81305 (rank : 876)	NC score	0.372602 (rank : 924)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2923	Shared Neighborhood Hits	690
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

APBB2_MOUSE
θ value	2.36792 (rank : 877)	NC score	0.007854 (rank : 1762)
Query Neighborhood Hits	1103	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

ARHGB_HUMAN
θ value	2.36792 (rank : 878)	NC score	0.009708 (rank : 1753)
Query Neighborhood Hits	1103	Target Neighborhood Hits	375	Shared Neighborhood Hits	42
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARI1A_HUMAN
θ value	2.36792 (rank : 879)	NC score	0.019956 (rank : 1713)
Query Neighborhood Hits	1103	Target Neighborhood Hits	787	Shared Neighborhood Hits	78
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ARS2_HUMAN
θ value	2.36792 (rank : 880)	NC score	0.030517 (rank : 1661)
Query Neighborhood Hits	1103	Target Neighborhood Hits	186	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

ARX_MOUSE
θ value	2.36792 (rank : 881)	NC score	-0.010271 (rank : 1788)
Query Neighborhood Hits	1103	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

CAC1F_MOUSE
θ value	2.36792 (rank : 882)	NC score	-0.001037 (rank : 1784)
Query Neighborhood Hits	1103	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CCAR1_MOUSE
θ value	2.36792 (rank : 883)	NC score	0.048759 (rank : 1605)
Query Neighborhood Hits	1103	Target Neighborhood Hits	414	Shared Neighborhood Hits	92
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

DHX16_HUMAN
θ value	2.36792 (rank : 884)	NC score	0.015641 (rank : 1733)
Query Neighborhood Hits	1103	Target Neighborhood Hits	356	Shared Neighborhood Hits	90
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

DNMBP_MOUSE
θ value	2.36792 (rank : 885)	NC score	0.066960 (rank : 1318)
Query Neighborhood Hits	1103	Target Neighborhood Hits	435	Shared Neighborhood Hits	87
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DPOD3_HUMAN
θ value	2.36792 (rank : 886)	NC score	0.023239 (rank : 1690)
Query Neighborhood Hits	1103	Target Neighborhood Hits	109	Shared Neighborhood Hits	36
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

GSK3A_HUMAN
θ value	2.36792 (rank : 887)	NC score	0.438960 (rank : 708)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	543
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

IF3A_MOUSE
θ value	2.36792 (rank : 888)	NC score	0.054232 (rank : 1517)
Query Neighborhood Hits	1103	Target Neighborhood Hits	871	Shared Neighborhood Hits	142
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

K0999_HUMAN
θ value	2.36792 (rank : 889)	NC score	0.499238 (rank : 432)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	569
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	2.36792 (rank : 890)	NC score	0.499471 (rank : 430)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	574
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KAPCB_MOUSE
θ value	2.36792 (rank : 891)	NC score	0.460550 (rank : 625)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	560
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

MK07_HUMAN
θ value	2.36792 (rank : 892)	NC score	0.473319 (rank : 566)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1087	Shared Neighborhood Hits	589
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MYO5C_HUMAN
θ value	2.36792 (rank : 893)	NC score	0.044717 (rank : 1621)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1206	Shared Neighborhood Hits	190
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NCOR1_HUMAN
θ value	2.36792 (rank : 894)	NC score	0.034049 (rank : 1654)
Query Neighborhood Hits	1103	Target Neighborhood Hits	577	Shared Neighborhood Hits	119
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

PDK1L_MOUSE
θ value	2.36792 (rank : 895)	NC score	0.488651 (rank : 470)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	551
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

RBBP8_HUMAN
θ value	2.36792 (rank : 896)	NC score	0.051977 (rank : 1560)
Query Neighborhood Hits	1103	Target Neighborhood Hits	476	Shared Neighborhood Hits	115
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

RBCC1_HUMAN
θ value	2.36792 (rank : 897)	NC score	0.061689 (rank : 1384)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	168
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

RBM25_HUMAN
θ value	2.36792 (rank : 898)	NC score	0.063299 (rank : 1361)
Query Neighborhood Hits	1103	Target Neighborhood Hits	682	Shared Neighborhood Hits	128
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

SBK1_HUMAN
θ value	2.36792 (rank : 899)	NC score	0.478959 (rank : 537)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	545
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SN1L1_HUMAN
θ value	2.36792 (rank : 900)	NC score	0.500832 (rank : 425)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	576
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

TP53B_MOUSE
θ value	2.36792 (rank : 901)	NC score	0.059049 (rank : 1426)
Query Neighborhood Hits	1103	Target Neighborhood Hits	644	Shared Neighborhood Hits	135
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ABTAP_MOUSE
θ value	3.0926 (rank : 902)	NC score	0.041666 (rank : 1631)
Query Neighborhood Hits	1103	Target Neighborhood Hits	381	Shared Neighborhood Hits	92
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

AN32E_MOUSE
θ value	3.0926 (rank : 903)	NC score	0.014390 (rank : 1738)
Query Neighborhood Hits	1103	Target Neighborhood Hits	257	Shared Neighborhood Hits	20
SwissProt Accessions	P97822, Q3TH89, Q8BPF8, Q8C2L4, Q8C7Q8, Q9CZD2	Gene names	Anp32e, Cpd1
Domain Architecture
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L) (Cerebellar postnatal development protein 1).

ARX_HUMAN
θ value	3.0926 (rank : 904)	NC score	-0.010510 (rank : 1789)
Query Neighborhood Hits	1103	Target Neighborhood Hits	401	Shared Neighborhood Hits	13
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

BPTF_HUMAN
θ value	3.0926 (rank : 905)	NC score	0.037568 (rank : 1643)
Query Neighborhood Hits	1103	Target Neighborhood Hits	786	Shared Neighborhood Hits	150
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

BSN_MOUSE
θ value	3.0926 (rank : 906)	NC score	0.058644 (rank : 1433)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2057	Shared Neighborhood Hits	238
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CAMKV_HUMAN
θ value	3.0926 (rank : 907)	NC score	0.429257 (rank : 726)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1084	Shared Neighborhood Hits	563
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	3.0926 (rank : 908)	NC score	0.430833 (rank : 721)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	538
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CDC27_HUMAN
θ value	3.0926 (rank : 909)	NC score	0.003633 (rank : 1778)
Query Neighborhood Hits	1103	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

DEK_HUMAN
θ value	3.0926 (rank : 910)	NC score	0.038862 (rank : 1641)
Query Neighborhood Hits	1103	Target Neighborhood Hits	199	Shared Neighborhood Hits	55
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

FANCJ_HUMAN
θ value	3.0926 (rank : 911)	NC score	0.009949 (rank : 1751)
Query Neighborhood Hits	1103	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BX63, Q8NCI5	Gene names	BRIP1, BACH1, FANCJ
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

FBX30_MOUSE
θ value	3.0926 (rank : 912)	NC score	0.008305 (rank : 1759)
Query Neighborhood Hits	1103	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJL1, Q8CI21, Q9D9X5	Gene names	Fbxo30
Domain Architecture
Description	F-box only protein 30.

GNDS_HUMAN
θ value	3.0926 (rank : 913)	NC score	0.004047 (rank : 1777)
Query Neighborhood Hits	1103	Target Neighborhood Hits	201	Shared Neighborhood Hits	20
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GOGA6_HUMAN
θ value	3.0926 (rank : 914)	NC score	0.048390 (rank : 1609)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1007	Shared Neighborhood Hits	150
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

HTSF1_MOUSE
θ value	3.0926 (rank : 915)	NC score	0.048926 (rank : 1604)
Query Neighborhood Hits	1103	Target Neighborhood Hits	425	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

IKBL_MOUSE
θ value	3.0926 (rank : 916)	NC score	0.168013 (rank : 1112)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	154
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

INHBA_HUMAN
θ value	3.0926 (rank : 917)	NC score	-0.002012 (rank : 1786)
Query Neighborhood Hits	1103	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P08476, Q14599	Gene names	INHBA
Domain Architecture
Description	Inhibin beta A chain precursor (Activin beta-A chain) (Erythroid differentiation protein) (EDF).

KCC2G_HUMAN
θ value	3.0926 (rank : 918)	NC score	0.462653 (rank : 611)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	556
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	3.0926 (rank : 919)	NC score	0.462600 (rank : 612)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	556
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KIF3A_MOUSE
θ value	3.0926 (rank : 920)	NC score	0.020729 (rank : 1705)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	120
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KSR2_HUMAN
θ value	3.0926 (rank : 921)	NC score	0.604635 (rank : 212)
Query Neighborhood Hits	1103	Target Neighborhood Hits	920	Shared Neighborhood Hits	567
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LRRF2_HUMAN
θ value	3.0926 (rank : 922)	NC score	0.048136 (rank : 1611)
Query Neighborhood Hits	1103	Target Neighborhood Hits	791	Shared Neighborhood Hits	128
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

MAP1A_HUMAN
θ value	3.0926 (rank : 923)	NC score	0.080866 (rank : 1227)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1626	Shared Neighborhood Hits	270
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MELPH_MOUSE
θ value	3.0926 (rank : 924)	NC score	0.010068 (rank : 1750)
Query Neighborhood Hits	1103	Target Neighborhood Hits	112	Shared Neighborhood Hits	20
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MP2K7_HUMAN
θ value	3.0926 (rank : 925)	NC score	0.515717 (rank : 341)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	563
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

NLK_HUMAN
θ value	3.0926 (rank : 926)	NC score	0.483685 (rank : 496)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	561
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	3.0926 (rank : 927)	NC score	0.483762 (rank : 495)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	561
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRDC_HUMAN
θ value	3.0926 (rank : 928)	NC score	0.015552 (rank : 1734)
Query Neighborhood Hits	1103	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
θ value	3.0926 (rank : 929)	NC score	0.016033 (rank : 1730)
Query Neighborhood Hits	1103	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRK_MOUSE
θ value	3.0926 (rank : 930)	NC score	0.505347 (rank : 405)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	570
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NUCKS_MOUSE
θ value	3.0926 (rank : 931)	NC score	0.063484 (rank : 1356)
Query Neighborhood Hits	1103	Target Neighborhood Hits	114	Shared Neighborhood Hits	40
SwissProt Accessions	Q80XU3, Q8BVD8	Gene names	Nucks1, Nucks
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (JC7).

PDXL2_MOUSE
θ value	3.0926 (rank : 932)	NC score	0.028587 (rank : 1669)
Query Neighborhood Hits	1103	Target Neighborhood Hits	213	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PIBF1_HUMAN
θ value	3.0926 (rank : 933)	NC score	0.069406 (rank : 1296)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1041	Shared Neighborhood Hits	177
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

RBCC1_MOUSE
θ value	3.0926 (rank : 934)	NC score	0.060591 (rank : 1401)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1048	Shared Neighborhood Hits	170
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RIPK3_HUMAN
θ value	3.0926 (rank : 935)	NC score	0.601670 (rank : 216)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	565
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RPGR1_MOUSE
θ value	3.0926 (rank : 936)	NC score	0.056781 (rank : 1469)
Query Neighborhood Hits	1103	Target Neighborhood Hits	713	Shared Neighborhood Hits	153
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RRMJ3_HUMAN
θ value	3.0926 (rank : 937)	NC score	0.018479 (rank : 1722)
Query Neighborhood Hits	1103	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6	Gene names	FTSJ3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

RTN1_MOUSE
θ value	3.0926 (rank : 938)	NC score	0.021142 (rank : 1702)
Query Neighborhood Hits	1103	Target Neighborhood Hits	189	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SETD2_HUMAN
θ value	3.0926 (rank : 939)	NC score	0.029989 (rank : 1664)
Query Neighborhood Hits	1103	Target Neighborhood Hits	412	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SGK2_MOUSE
θ value	3.0926 (rank : 940)	NC score	0.459173 (rank : 630)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	559
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ST32A_MOUSE
θ value	3.0926 (rank : 941)	NC score	0.480175 (rank : 525)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	557
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

SURF6_HUMAN
θ value	3.0926 (rank : 942)	NC score	0.022144 (rank : 1697)
Query Neighborhood Hits	1103	Target Neighborhood Hits	104	Shared Neighborhood Hits	26
SwissProt Accessions	O75683, Q9BRK9, Q9BTZ5, Q9UK24	Gene names	SURF6, SURF-6
Domain Architecture
Description	Surfeit locus protein 6.

TAF3_MOUSE
θ value	3.0926 (rank : 943)	NC score	0.051181 (rank : 1578)
Query Neighborhood Hits	1103	Target Neighborhood Hits	463	Shared Neighborhood Hits	98
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TRIO_HUMAN
θ value	3.0926 (rank : 944)	NC score	0.422265 (rank : 743)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1580	Shared Neighborhood Hits	634
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

WIRE_HUMAN
θ value	3.0926 (rank : 945)	NC score	0.025225 (rank : 1682)
Query Neighborhood Hits	1103	Target Neighborhood Hits	329	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ZC313_HUMAN
θ value	3.0926 (rank : 946)	NC score	0.072593 (rank : 1268)
Query Neighborhood Hits	1103	Target Neighborhood Hits	772	Shared Neighborhood Hits	184
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZRAB2_HUMAN
θ value	3.0926 (rank : 947)	NC score	0.038553 (rank : 1642)
Query Neighborhood Hits	1103	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	O95218, Q9UP63	Gene names	ZRANB2, ZIS, ZNF265
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 2 Zinc finger protein 265 (Zinc finger, splicing).

AN13A_MOUSE
θ value	4.03905 (rank : 948)	NC score	0.188935 (rank : 1099)
Query Neighborhood Hits	1103	Target Neighborhood Hits	226	Shared Neighborhood Hits	193
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

ARS2_MOUSE
θ value	4.03905 (rank : 949)	NC score	0.028919 (rank : 1667)
Query Neighborhood Hits	1103	Target Neighborhood Hits	212	Shared Neighborhood Hits	49
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

BAT2_HUMAN
θ value	4.03905 (rank : 950)	NC score	0.037160 (rank : 1646)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	108
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAZ1A_HUMAN
θ value	4.03905 (rank : 951)	NC score	0.039189 (rank : 1640)
Query Neighborhood Hits	1103	Target Neighborhood Hits	693	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

BSN_HUMAN
θ value	4.03905 (rank : 952)	NC score	0.056886 (rank : 1467)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1537	Shared Neighborhood Hits	206
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CA065_HUMAN
θ value	4.03905 (rank : 953)	NC score	0.053266 (rank : 1539)
Query Neighborhood Hits	1103	Target Neighborhood Hits	469	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CALD1_HUMAN
θ value	4.03905 (rank : 954)	NC score	0.064299 (rank : 1348)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	155
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CLSPN_MOUSE
θ value	4.03905 (rank : 955)	NC score	0.041099 (rank : 1633)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	82
SwissProt Accessions	Q80YR7, Q69GM2	Gene names	Clspn
Domain Architecture	No domain graphic available
Description	Claspin.

INGR1_HUMAN
θ value	4.03905 (rank : 956)	NC score	0.008345 (rank : 1758)
Query Neighborhood Hits	1103	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P15260	Gene names	IFNGR1
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen) (CDw119).

KINH_MOUSE
θ value	4.03905 (rank : 957)	NC score	0.036421 (rank : 1649)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1082	Shared Neighborhood Hits	178
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KSR1_MOUSE
θ value	4.03905 (rank : 958)	NC score	0.613810 (rank : 203)
Query Neighborhood Hits	1103	Target Neighborhood Hits	870	Shared Neighborhood Hits	563
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MIA2_MOUSE
θ value	4.03905 (rank : 959)	NC score	0.017121 (rank : 1727)
Query Neighborhood Hits	1103	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MOK_HUMAN
θ value	4.03905 (rank : 960)	NC score	0.444463 (rank : 694)
Query Neighborhood Hits	1103	Target Neighborhood Hits	807	Shared Neighborhood Hits	531
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MRCKG_MOUSE
θ value	4.03905 (rank : 961)	NC score	0.413166 (rank : 776)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1466	Shared Neighborhood Hits	646
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

NADAP_HUMAN
θ value	4.03905 (rank : 962)	NC score	0.020200 (rank : 1709)
Query Neighborhood Hits	1103	Target Neighborhood Hits	208	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

NFM_MOUSE
θ value	4.03905 (rank : 963)	NC score	0.039746 (rank : 1637)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1159	Shared Neighborhood Hits	203
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NUCKS_HUMAN
θ value	4.03905 (rank : 964)	NC score	0.059631 (rank : 1410)
Query Neighborhood Hits	1103	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H1E3, Q9H1D6, Q9H723	Gene names	NUCKS1, NUCKS
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1).

PDK1L_HUMAN
θ value	4.03905 (rank : 965)	NC score	0.487536 (rank : 478)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	550
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDXL2_HUMAN
θ value	4.03905 (rank : 966)	NC score	0.019699 (rank : 1715)
Query Neighborhood Hits	1103	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZ53, Q6UVY4, Q8WUV6	Gene names	PODXL2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PHKG2_HUMAN
θ value	4.03905 (rank : 967)	NC score	0.453881 (rank : 667)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	561
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PKNX2_HUMAN
θ value	4.03905 (rank : 968)	NC score	-0.000154 (rank : 1782)
Query Neighborhood Hits	1103	Target Neighborhood Hits	133	Shared Neighborhood Hits	6
SwissProt Accessions	Q96KN3, Q63HL6, Q86XD1	Gene names	PKNOX2, PREP2
Domain Architecture
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

PLEC1_HUMAN
θ value	4.03905 (rank : 969)	NC score	0.040054 (rank : 1636)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1326	Shared Neighborhood Hits	161
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

REST_HUMAN
θ value	4.03905 (rank : 970)	NC score	0.066099 (rank : 1327)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1605	Shared Neighborhood Hits	228
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RRBP1_MOUSE
θ value	4.03905 (rank : 971)	NC score	0.059449 (rank : 1416)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1650	Shared Neighborhood Hits	244
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

RYR2_HUMAN
θ value	4.03905 (rank : 972)	NC score	0.006942 (rank : 1766)
Query Neighborhood Hits	1103	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

SH3BG_MOUSE
θ value	4.03905 (rank : 973)	NC score	0.012304 (rank : 1744)
Query Neighborhood Hits	1103	Target Neighborhood Hits	99	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WUZ7	Gene names	Sh3bgr
Domain Architecture
Description	SH3 domain-binding glutamic acid-rich protein (SH3BGR protein).

SNCAP_HUMAN
θ value	4.03905 (rank : 974)	NC score	0.338621 (rank : 975)
Query Neighborhood Hits	1103	Target Neighborhood Hits	313	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

SYNPO_HUMAN
θ value	4.03905 (rank : 975)	NC score	0.015752 (rank : 1732)
Query Neighborhood Hits	1103	Target Neighborhood Hits	281	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TCAL4_HUMAN
θ value	4.03905 (rank : 976)	NC score	0.010763 (rank : 1748)
Query Neighborhood Hits	1103	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96EI5, Q8WY12, Q9H2H1, Q9H775	Gene names	TCEAL4
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4).

TRI44_HUMAN
θ value	4.03905 (rank : 977)	NC score	0.017206 (rank : 1726)
Query Neighborhood Hits	1103	Target Neighborhood Hits	393	Shared Neighborhood Hits	64
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

TRPV4_HUMAN
θ value	4.03905 (rank : 978)	NC score	0.044770 (rank : 1620)
Query Neighborhood Hits	1103	Target Neighborhood Hits	150	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

ACV1B_HUMAN
θ value	5.27518 (rank : 979)	NC score	0.480552 (rank : 523)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	543
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

AL2S7_HUMAN
θ value	5.27518 (rank : 980)	NC score	0.481828 (rank : 510)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	557
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

AN36A_HUMAN
θ value	5.27518 (rank : 981)	NC score	0.366008 (rank : 939)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	234
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANR38_HUMAN
θ value	5.27518 (rank : 982)	NC score	0.297784 (rank : 1016)
Query Neighborhood Hits	1103	Target Neighborhood Hits	443	Shared Neighborhood Hits	249
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

AT2B3_HUMAN
θ value	5.27518 (rank : 983)	NC score	-0.003208 (rank : 1787)
Query Neighborhood Hits	1103	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q16720, Q12995, Q16858	Gene names	ATP2B3
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 3 (EC 3.6.3.8) (PMCA3) (Plasma membrane calcium pump isoform 3) (Plasma membrane calcium ATPase isoform 3).

CASC3_HUMAN
θ value	5.27518 (rank : 984)	NC score	0.020976 (rank : 1704)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	O15234	Gene names	CASC3, MLN51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node protein 51) (Protein MLN 51) (Protein barentsz) (Btz).

CE290_HUMAN
θ value	5.27518 (rank : 985)	NC score	0.060421 (rank : 1403)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1553	Shared Neighborhood Hits	203
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

DNMT1_HUMAN
θ value	5.27518 (rank : 986)	NC score	0.035880 (rank : 1651)
Query Neighborhood Hits	1103	Target Neighborhood Hits	401	Shared Neighborhood Hits	111
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

E41L1_HUMAN
θ value	5.27518 (rank : 987)	NC score	0.004243 (rank : 1775)
Query Neighborhood Hits	1103	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

ESCO2_HUMAN
θ value	5.27518 (rank : 988)	NC score	0.007241 (rank : 1765)
Query Neighborhood Hits	1103	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q56NI9	Gene names	ESCO2
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2).

FBX38_MOUSE
θ value	5.27518 (rank : 989)	NC score	0.019014 (rank : 1717)
Query Neighborhood Hits	1103	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BMI0, Q8BTQ4, Q8C0H4	Gene names	Fbxo38
Domain Architecture	No domain graphic available
Description	F-box only protein 38 (Modulator of KLF7 activity) (MoKA).

GBP2_HUMAN
θ value	5.27518 (rank : 990)	NC score	0.018756 (rank : 1721)
Query Neighborhood Hits	1103	Target Neighborhood Hits	349	Shared Neighborhood Hits	73
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

GLMN_HUMAN
θ value	5.27518 (rank : 991)	NC score	0.007714 (rank : 1763)
Query Neighborhood Hits	1103	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q92990, Q9BVE8	Gene names	GLMN, FAP48, VMGLOM
Domain Architecture	No domain graphic available
Description	Glomulin (FKBP-associated protein) (FK506-binding protein-associated protein) (FAP).

IASPP_MOUSE
θ value	5.27518 (rank : 992)	NC score	0.288616 (rank : 1021)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1024	Shared Neighborhood Hits	325
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

KCNH6_HUMAN
θ value	5.27518 (rank : 993)	NC score	0.008048 (rank : 1761)
Query Neighborhood Hits	1103	Target Neighborhood Hits	222	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

MINT_HUMAN
θ value	5.27518 (rank : 994)	NC score	0.051695 (rank : 1566)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1291	Shared Neighborhood Hits	206
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MP2K6_HUMAN
θ value	5.27518 (rank : 995)	NC score	0.507960 (rank : 393)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	558
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	5.27518 (rank : 996)	NC score	0.507976 (rank : 391)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	559
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MPP10_HUMAN
θ value	5.27518 (rank : 997)	NC score	0.051197 (rank : 1576)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	85
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MTMR3_HUMAN
θ value	5.27518 (rank : 998)	NC score	0.004068 (rank : 1776)
Query Neighborhood Hits	1103	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MYH13_HUMAN
θ value	5.27518 (rank : 999)	NC score	0.043820 (rank : 1626)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1504	Shared Neighborhood Hits	189
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYO3A_HUMAN
θ value	5.27518 (rank : 1000)	NC score	0.455407 (rank : 658)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1033	Shared Neighborhood Hits	615
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

NCKX1_HUMAN
θ value	5.27518 (rank : 1001)	NC score	0.018891 (rank : 1719)
Query Neighborhood Hits	1103	Target Neighborhood Hits	223	Shared Neighborhood Hits	45
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

NEB1_HUMAN
θ value	5.27518 (rank : 1002)	NC score	0.040430 (rank : 1634)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	147
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NFH_MOUSE
θ value	5.27518 (rank : 1003)	NC score	0.046674 (rank : 1614)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2247	Shared Neighborhood Hits	307
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NIPBL_HUMAN
θ value	5.27518 (rank : 1004)	NC score	0.077602 (rank : 1238)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1311	Shared Neighborhood Hits	266
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NRK_HUMAN
θ value	5.27518 (rank : 1005)	NC score	0.506879 (rank : 395)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	576
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

OS9_HUMAN
θ value	5.27518 (rank : 1006)	NC score	0.018809 (rank : 1720)
Query Neighborhood Hits	1103	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

PELP1_HUMAN
θ value	5.27518 (rank : 1007)	NC score	0.048245 (rank : 1610)
Query Neighborhood Hits	1103	Target Neighborhood Hits	596	Shared Neighborhood Hits	108
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PHKG2_MOUSE
θ value	5.27518 (rank : 1008)	NC score	0.460138 (rank : 627)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	561
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

POT22_HUMAN
θ value	5.27518 (rank : 1009)	NC score	0.319716 (rank : 999)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	224
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

RB6I2_HUMAN
θ value	5.27518 (rank : 1010)	NC score	0.064863 (rank : 1344)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1584	Shared Neighborhood Hits	235
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

SN1L1_MOUSE
θ value	5.27518 (rank : 1011)	NC score	0.504882 (rank : 408)
Query Neighborhood Hits	1103	Target Neighborhood Hits	895	Shared Neighborhood Hits	575
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SPTB1_HUMAN
θ value	5.27518 (rank : 1012)	NC score	0.020059 (rank : 1710)
Query Neighborhood Hits	1103	Target Neighborhood Hits	541	Shared Neighborhood Hits	95
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SRRM1_MOUSE
θ value	5.27518 (rank : 1013)	NC score	0.064083 (rank : 1350)
Query Neighborhood Hits	1103	Target Neighborhood Hits	966	Shared Neighborhood Hits	153
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STA13_MOUSE
θ value	5.27518 (rank : 1014)	NC score	-0.000593 (rank : 1783)
Query Neighborhood Hits	1103	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

T22D3_HUMAN
θ value	5.27518 (rank : 1015)	NC score	0.007537 (rank : 1764)
Query Neighborhood Hits	1103	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q99576, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5, Q9UG13	Gene names	TSC22D3, DSIPI, GILZ
Domain Architecture
Description	TSC22 domain family protein 3 (Glucocorticoid-induced leucine zipper protein) (Delta sleep-inducing peptide immunoreactor) (DSIP- immunoreactive peptide) (Protein DIP) (hDIP) (TSC-22-like protein) (TSC-22R).

T3JAM_HUMAN
θ value	5.27518 (rank : 1016)	NC score	0.042028 (rank : 1630)
Query Neighborhood Hits	1103	Target Neighborhood Hits	533	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TR150_MOUSE
θ value	5.27518 (rank : 1017)	NC score	0.057416 (rank : 1454)
Query Neighborhood Hits	1103	Target Neighborhood Hits	468	Shared Neighborhood Hits	145
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TROAP_HUMAN
θ value	5.27518 (rank : 1018)	NC score	0.015011 (rank : 1736)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

TTC15_MOUSE
θ value	5.27518 (rank : 1019)	NC score	0.012212 (rank : 1745)
Query Neighborhood Hits	1103	Target Neighborhood Hits	113	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K2L8, Q8BX27	Gene names	Ttc15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

ZFP91_MOUSE
θ value	5.27518 (rank : 1020)	NC score	-0.020005 (rank : 1793)
Query Neighborhood Hits	1103	Target Neighborhood Hits	742	Shared Neighborhood Hits	20
SwissProt Accessions	Q62511, Q8BPY3, Q8C2B4	Gene names	Zfp91, Pzf
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 (Zfp-91) (Zinc finger protein PZF) (Penta Zf protein).

ZN496_HUMAN
θ value	5.27518 (rank : 1021)	NC score	-0.021470 (rank : 1794)
Query Neighborhood Hits	1103	Target Neighborhood Hits	743	Shared Neighborhood Hits	16
SwissProt Accessions	Q96IT1	Gene names	ZNF496
Domain Architecture	No domain graphic available
Description	Zinc finger protein 496.

ZYX_MOUSE
θ value	5.27518 (rank : 1022)	NC score	0.009742 (rank : 1752)
Query Neighborhood Hits	1103	Target Neighborhood Hits	347	Shared Neighborhood Hits	29
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

ARI3A_MOUSE
θ value	6.88961 (rank : 1023)	NC score	0.012792 (rank : 1743)
Query Neighborhood Hits	1103	Target Neighborhood Hits	64	Shared Neighborhood Hits	15
SwissProt Accessions	Q62431	Gene names	Arid3a, Dri1, Dril1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (Dead ringer-like protein 1) (B-cell regulator of IgH transcription) (Bright).

C8AP2_MOUSE
θ value	6.88961 (rank : 1024)	NC score	0.030285 (rank : 1663)
Query Neighborhood Hits	1103	Target Neighborhood Hits	405	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CAF1A_HUMAN
θ value	6.88961 (rank : 1025)	NC score	0.049555 (rank : 1601)
Query Neighborhood Hits	1103	Target Neighborhood Hits	750	Shared Neighborhood Hits	125
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CENG1_HUMAN
θ value	6.88961 (rank : 1026)	NC score	0.166410 (rank : 1114)
Query Neighborhood Hits	1103	Target Neighborhood Hits	544	Shared Neighborhood Hits	231
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	6.88961 (rank : 1027)	NC score	0.168795 (rank : 1111)
Query Neighborhood Hits	1103	Target Neighborhood Hits	531	Shared Neighborhood Hits	233
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CIP4_HUMAN
θ value	6.88961 (rank : 1028)	NC score	0.101641 (rank : 1172)
Query Neighborhood Hits	1103	Target Neighborhood Hits	374	Shared Neighborhood Hits	86
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

DNL1_HUMAN
θ value	6.88961 (rank : 1029)	NC score	0.015782 (rank : 1731)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	48
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

EPN1_MOUSE
θ value	6.88961 (rank : 1030)	NC score	0.005962 (rank : 1770)
Query Neighborhood Hits	1103	Target Neighborhood Hits	240	Shared Neighborhood Hits	31
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

GPTC3_HUMAN
θ value	6.88961 (rank : 1031)	NC score	0.009152 (rank : 1755)
Query Neighborhood Hits	1103	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q96I76, Q5JYH2, Q8NDJ2, Q9H9Z3	Gene names	GPATC3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

HS90A_HUMAN
θ value	6.88961 (rank : 1032)	NC score	0.014045 (rank : 1739)
Query Neighborhood Hits	1103	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	P07900, Q2PP14, Q9BVQ5	Gene names	HSP90AA1, HSP90A, HSPC1, HSPCA
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (NY-REN-38 antigen).

IF2P_HUMAN
θ value	6.88961 (rank : 1033)	NC score	0.069558 (rank : 1294)
Query Neighborhood Hits	1103	Target Neighborhood Hits	889	Shared Neighborhood Hits	151
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

KC1G2_MOUSE
θ value	6.88961 (rank : 1034)	NC score	0.311409 (rank : 1008)
Query Neighborhood Hits	1103	Target Neighborhood Hits	695	Shared Neighborhood Hits	464
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KIF4A_MOUSE
θ value	6.88961 (rank : 1035)	NC score	0.036615 (rank : 1648)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1033	Shared Neighborhood Hits	172
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MIER1_HUMAN
θ value	6.88961 (rank : 1036)	NC score	0.009478 (rank : 1754)
Query Neighborhood Hits	1103	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N108, Q5T104, Q6AHY8, Q86TB4, Q8N156, Q8N161, Q8NC37, Q8NES4, Q8NES5, Q8NES6, Q8WWG2, Q9HCG2	Gene names	MIER1, KIAA1610
Domain Architecture	No domain graphic available
Description	Mesoderm induction early response protein 1 (Mi-er1) (hmi-er1) (Early response 1) (Er1).

MKNK1_MOUSE
θ value	6.88961 (rank : 1037)	NC score	0.413201 (rank : 775)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	533
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MRCKG_HUMAN
θ value	6.88961 (rank : 1038)	NC score	0.412248 (rank : 784)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1519	Shared Neighborhood Hits	650
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MYO6_MOUSE
θ value	6.88961 (rank : 1039)	NC score	0.028150 (rank : 1671)
Query Neighborhood Hits	1103	Target Neighborhood Hits	586	Shared Neighborhood Hits	103
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

NAL13_HUMAN
θ value	6.88961 (rank : 1040)	NC score	-0.001242 (rank : 1785)
Query Neighborhood Hits	1103	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NCOR1_MOUSE
θ value	6.88961 (rank : 1041)	NC score	0.028679 (rank : 1668)
Query Neighborhood Hits	1103	Target Neighborhood Hits	521	Shared Neighborhood Hits	104
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NFH_HUMAN
θ value	6.88961 (rank : 1042)	NC score	0.037174 (rank : 1645)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1242	Shared Neighborhood Hits	202
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

OSBL5_MOUSE
θ value	6.88961 (rank : 1043)	NC score	0.013519 (rank : 1742)
Query Neighborhood Hits	1103	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

PFTK1_MOUSE
θ value	6.88961 (rank : 1044)	NC score	0.476565 (rank : 545)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	557
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PHLB1_HUMAN
θ value	6.88961 (rank : 1045)	NC score	0.053041 (rank : 1543)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1038	Shared Neighborhood Hits	166
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PININ_HUMAN
θ value	6.88961 (rank : 1046)	NC score	0.063676 (rank : 1353)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	161
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

RERE_HUMAN
θ value	6.88961 (rank : 1047)	NC score	0.024590 (rank : 1687)
Query Neighborhood Hits	1103	Target Neighborhood Hits	779	Shared Neighborhood Hits	112
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SELPL_MOUSE
θ value	6.88961 (rank : 1048)	NC score	0.017923 (rank : 1724)
Query Neighborhood Hits	1103	Target Neighborhood Hits	588	Shared Neighborhood Hits	80
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SFPQ_HUMAN
θ value	6.88961 (rank : 1049)	NC score	0.021818 (rank : 1699)
Query Neighborhood Hits	1103	Target Neighborhood Hits	986	Shared Neighborhood Hits	121
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SIAL_HUMAN
θ value	6.88961 (rank : 1050)	NC score	0.019979 (rank : 1712)
Query Neighborhood Hits	1103	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	P21815	Gene names	IBSP, BNSP
Domain Architecture
Description	Bone sialoprotein-2 precursor (Bone sialoprotein II) (BSP II) (Cell- binding sialoprotein) (Integrin-binding sialoprotein).

SIRT1_HUMAN
θ value	6.88961 (rank : 1051)	NC score	0.006164 (rank : 1769)
Query Neighborhood Hits	1103	Target Neighborhood Hits	44	Shared Neighborhood Hits	11
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

SMRC2_HUMAN
θ value	6.88961 (rank : 1052)	NC score	0.024654 (rank : 1686)
Query Neighborhood Hits	1103	Target Neighborhood Hits	499	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SRPK2_MOUSE
θ value	6.88961 (rank : 1053)	NC score	0.213850 (rank : 1070)
Query Neighborhood Hits	1103	Target Neighborhood Hits	765	Shared Neighborhood Hits	404
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SSRP1_MOUSE
θ value	6.88961 (rank : 1054)	NC score	0.006461 (rank : 1768)
Query Neighborhood Hits	1103	Target Neighborhood Hits	193	Shared Neighborhood Hits	34
SwissProt Accessions	Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6	Gene names	Ssrp1
Domain Architecture
Description	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Structure-specific recognition protein 1) (Recombination signal sequence recognition protein 1) (T160).

TCEA3_HUMAN
θ value	6.88961 (rank : 1055)	NC score	0.002000 (rank : 1781)
Query Neighborhood Hits	1103	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	O75764	Gene names	TCEA3, TFIISH
Domain Architecture
Description	Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h).

TPR_HUMAN
θ value	6.88961 (rank : 1056)	NC score	0.068755 (rank : 1301)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1921	Shared Neighborhood Hits	261
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

XPC_HUMAN
θ value	6.88961 (rank : 1057)	NC score	0.011324 (rank : 1746)
Query Neighborhood Hits	1103	Target Neighborhood Hits	64	Shared Neighborhood Hits	18
SwissProt Accessions	Q01831, Q96AX0	Gene names	XPC, XPCC
Domain Architecture
Description	DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125).

ZBT17_HUMAN
θ value	6.88961 (rank : 1058)	NC score	-0.023241 (rank : 1795)
Query Neighborhood Hits	1103	Target Neighborhood Hits	925	Shared Neighborhood Hits	37
SwissProt Accessions	Q13105, Q15932, Q5JYB2, Q9NUC9	Gene names	ZBTB17, MIZ1, ZNF151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Myc-interacting zinc finger protein) (Miz-1 protein).

ACV1C_MOUSE
θ value	8.99809 (rank : 1059)	NC score	0.473207 (rank : 567)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	522
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

AFF4_MOUSE
θ value	8.99809 (rank : 1060)	NC score	0.026834 (rank : 1676)
Query Neighborhood Hits	1103	Target Neighborhood Hits	581	Shared Neighborhood Hits	108
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ATRX_MOUSE
θ value	8.99809 (rank : 1061)	NC score	0.043951 (rank : 1625)
Query Neighborhood Hits	1103	Target Neighborhood Hits	682	Shared Neighborhood Hits	150
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

BCL9_HUMAN
θ value	8.99809 (rank : 1062)	NC score	0.019945 (rank : 1714)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1008	Shared Neighborhood Hits	100
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CCD55_MOUSE
θ value	8.99809 (rank : 1063)	NC score	0.051797 (rank : 1564)
Query Neighborhood Hits	1103	Target Neighborhood Hits	519	Shared Neighborhood Hits	133
SwissProt Accessions	Q5NCR9	Gene names	Ccdc55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

CD2L7_HUMAN
θ value	8.99809 (rank : 1064)	NC score	0.489838 (rank : 462)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1275	Shared Neighborhood Hits	624
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CHD9_MOUSE
θ value	8.99809 (rank : 1065)	NC score	0.008696 (rank : 1757)
Query Neighborhood Hits	1103	Target Neighborhood Hits	427	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

CNGA1_MOUSE
θ value	8.99809 (rank : 1066)	NC score	0.010574 (rank : 1749)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	35
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

DAXX_MOUSE
θ value	8.99809 (rank : 1067)	NC score	0.020021 (rank : 1711)
Query Neighborhood Hits	1103	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

DC1I1_MOUSE
θ value	8.99809 (rank : 1068)	NC score	0.002916 (rank : 1779)
Query Neighborhood Hits	1103	Target Neighborhood Hits	206	Shared Neighborhood Hits	23
SwissProt Accessions	O88485, O88486	Gene names	Dync1i1, Dnci1, Dncic1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

DLGP2_MOUSE
θ value	8.99809 (rank : 1069)	NC score	0.004396 (rank : 1774)
Query Neighborhood Hits	1103	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BJ42, Q6XBF3	Gene names	Dlgap2, Dap2
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 2 (DAP-2) (SAP90/PSD-95-associated protein 2) (SAPAP2) (PSD-95/SAP90-binding protein 2).

ERN1_HUMAN
θ value	8.99809 (rank : 1070)	NC score	0.491664 (rank : 455)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	550
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FYB_HUMAN
θ value	8.99809 (rank : 1071)	NC score	0.022923 (rank : 1691)
Query Neighborhood Hits	1103	Target Neighborhood Hits	379	Shared Neighborhood Hits	67
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GRIP1_HUMAN
θ value	8.99809 (rank : 1072)	NC score	0.006462 (rank : 1767)
Query Neighborhood Hits	1103	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

HUWE1_HUMAN
θ value	8.99809 (rank : 1073)	NC score	0.008243 (rank : 1760)
Query Neighborhood Hits	1103	Target Neighborhood Hits	443	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

IDI1_MOUSE
θ value	8.99809 (rank : 1074)	NC score	0.004461 (rank : 1773)
Query Neighborhood Hits	1103	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P58044	Gene names	Idi1
Domain Architecture
Description	Isopentenyl-diphosphate delta-isomerase 1 (EC 5.3.3.2) (IPP isomerase 1) (Isopentenyl pyrophosphate isomerase 1) (IPPI1).

INCE_HUMAN
θ value	8.99809 (rank : 1075)	NC score	0.069041 (rank : 1299)
Query Neighborhood Hits	1103	Target Neighborhood Hits	978	Shared Neighborhood Hits	160
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

JHD1B_MOUSE
θ value	8.99809 (rank : 1076)	NC score	0.002630 (rank : 1780)
Query Neighborhood Hits	1103	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

KC1G2_HUMAN
θ value	8.99809 (rank : 1077)	NC score	0.315469 (rank : 1003)
Query Neighborhood Hits	1103	Target Neighborhood Hits	693	Shared Neighborhood Hits	464
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KI67_HUMAN
θ value	8.99809 (rank : 1078)	NC score	0.053143 (rank : 1542)
Query Neighborhood Hits	1103	Target Neighborhood Hits	581	Shared Neighborhood Hits	137
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

M4K1_HUMAN
θ value	8.99809 (rank : 1079)	NC score	0.512432 (rank : 355)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	571
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MYT1L_HUMAN
θ value	8.99809 (rank : 1080)	NC score	0.026479 (rank : 1677)
Query Neighborhood Hits	1103	Target Neighborhood Hits	471	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

MYT1L_MOUSE
θ value	8.99809 (rank : 1081)	NC score	0.023273 (rank : 1689)
Query Neighborhood Hits	1103	Target Neighborhood Hits	461	Shared Neighborhood Hits	90
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

NASP_HUMAN
θ value	8.99809 (rank : 1082)	NC score	0.074193 (rank : 1255)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	178
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

NOG2_HUMAN
θ value	8.99809 (rank : 1083)	NC score	0.009031 (rank : 1756)
Query Neighborhood Hits	1103	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

NTKL_HUMAN
θ value	8.99809 (rank : 1084)	NC score	0.144798 (rank : 1124)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	170
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

PASK_MOUSE
θ value	8.99809 (rank : 1085)	NC score	0.471337 (rank : 581)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	557
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PFTK1_HUMAN
θ value	8.99809 (rank : 1086)	NC score	0.475352 (rank : 551)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	556
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

RERE_MOUSE
θ value	8.99809 (rank : 1087)	NC score	0.025611 (rank : 1681)
Query Neighborhood Hits	1103	Target Neighborhood Hits	785	Shared Neighborhood Hits	97
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RTN4_HUMAN
θ value	8.99809 (rank : 1088)	NC score	0.024995 (rank : 1683)
Query Neighborhood Hits	1103	Target Neighborhood Hits	357	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SFPQ_MOUSE
θ value	8.99809 (rank : 1089)	NC score	0.019398 (rank : 1716)
Query Neighborhood Hits	1103	Target Neighborhood Hits	958	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SN1L2_HUMAN
θ value	8.99809 (rank : 1090)	NC score	0.505846 (rank : 401)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	584
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SRBS1_HUMAN
θ value	8.99809 (rank : 1091)	NC score	0.065997 (rank : 1329)
Query Neighborhood Hits	1103	Target Neighborhood Hits	396	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRPK2_HUMAN
θ value	8.99809 (rank : 1092)	NC score	0.211379 (rank : 1075)
Query Neighborhood Hits	1103	Target Neighborhood Hits	664	Shared Neighborhood Hits	391
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRRM1_HUMAN
θ value	8.99809 (rank : 1093)	NC score	0.061213 (rank : 1390)
Query Neighborhood Hits	1103	Target Neighborhood Hits	690	Shared Neighborhood Hits	116
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

T2FA_HUMAN
θ value	8.99809 (rank : 1094)	NC score	0.044454 (rank : 1622)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	55
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

TIM_HUMAN
θ value	8.99809 (rank : 1095)	NC score	0.005846 (rank : 1771)
Query Neighborhood Hits	1103	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNS1, O94802, Q86VM1, Q8IWH3	Gene names	TIMELESS, TIM, TIM1, TIMELESS1
Domain Architecture	No domain graphic available
Description	Timeless homolog (hTIM).

TPM2_HUMAN
θ value	8.99809 (rank : 1096)	NC score	0.035967 (rank : 1650)
Query Neighborhood Hits	1103	Target Neighborhood Hits	677	Shared Neighborhood Hits	96
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TRPV4_MOUSE
θ value	8.99809 (rank : 1097)	NC score	0.039294 (rank : 1639)
Query Neighborhood Hits	1103	Target Neighborhood Hits	117	Shared Neighborhood Hits	66
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TSKS_HUMAN
θ value	8.99809 (rank : 1098)	NC score	0.023757 (rank : 1688)
Query Neighborhood Hits	1103	Target Neighborhood Hits	220	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UJT2, Q8WXJ0	Gene names	STK22S1, TSKS, TSKS1
Domain Architecture	No domain graphic available
Description	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1).

TXND2_HUMAN
θ value	8.99809 (rank : 1099)	NC score	0.055949 (rank : 1488)
Query Neighborhood Hits	1103	Target Neighborhood Hits	793	Shared Neighborhood Hits	166
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

VRK3_MOUSE
θ value	8.99809 (rank : 1100)	NC score	0.156297 (rank : 1120)
Query Neighborhood Hits	1103	Target Neighborhood Hits	342	Shared Neighborhood Hits	247
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WDR60_HUMAN
θ value	8.99809 (rank : 1101)	NC score	0.028273 (rank : 1670)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WVS4, Q9NW58	Gene names	WDR60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

WIRE_MOUSE
θ value	8.99809 (rank : 1102)	NC score	0.021142 (rank : 1701)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

ZF106_HUMAN
θ value	8.99809 (rank : 1103)	NC score	0.005239 (rank : 1772)
Query Neighborhood Hits	1103	Target Neighborhood Hits	470	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

AAK1_HUMAN
θ value	θ > 10 (rank : 1104)	NC score	0.417606 (rank : 755)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1077	Shared Neighborhood Hits	568
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	θ > 10 (rank : 1105)	NC score	0.417347 (rank : 757)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1051	Shared Neighborhood Hits	565
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAPK1_HUMAN
θ value	θ > 10 (rank : 1106)	NC score	0.506537 (rank : 397)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 1107)	NC score	0.505971 (rank : 399)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	563
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 1108)	NC score	0.500967 (rank : 424)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	562
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 1109)	NC score	0.633446 (rank : 185)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1243	Shared Neighborhood Hits	581
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 1110)	NC score	0.638439 (rank : 174)
Query Neighborhood Hits	1103	Target Neighborhood Hits	942	Shared Neighborhood Hits	552
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI2_HUMAN
θ value	θ > 10 (rank : 1111)	NC score	0.056974 (rank : 1464)
Query Neighborhood Hits	1103	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 1112)	NC score	0.054026 (rank : 1523)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	52
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABTB1_HUMAN
θ value	θ > 10 (rank : 1113)	NC score	0.114462 (rank : 1161)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	140
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

ABTB1_MOUSE
θ value	θ > 10 (rank : 1114)	NC score	0.132120 (rank : 1132)
Query Neighborhood Hits	1103	Target Neighborhood Hits	349	Shared Neighborhood Hits	154
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ABTB2_HUMAN
θ value	θ > 10 (rank : 1115)	NC score	0.261986 (rank : 1046)
Query Neighborhood Hits	1103	Target Neighborhood Hits	391	Shared Neighborhood Hits	209
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
θ value	θ > 10 (rank : 1116)	NC score	0.255460 (rank : 1050)
Query Neighborhood Hits	1103	Target Neighborhood Hits	414	Shared Neighborhood Hits	210
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ACV1B_MOUSE
θ value	θ > 10 (rank : 1117)	NC score	0.479973 (rank : 528)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	542
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 1118)	NC score	0.472895 (rank : 571)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	518
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 1119)	NC score	0.507238 (rank : 394)
Query Neighborhood Hits	1103	Target Neighborhood Hits	716	Shared Neighborhood Hits	519
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 1120)	NC score	0.519638 (rank : 325)
Query Neighborhood Hits	1103	Target Neighborhood Hits	739	Shared Neighborhood Hits	531
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 1121)	NC score	0.499525 (rank : 429)
Query Neighborhood Hits	1103	Target Neighborhood Hits	760	Shared Neighborhood Hits	544
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 1122)	NC score	0.503290 (rank : 416)
Query Neighborhood Hits	1103	Target Neighborhood Hits	768	Shared Neighborhood Hits	549
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AHI1_HUMAN
θ value	θ > 10 (rank : 1123)	NC score	0.071453 (rank : 1281)
Query Neighborhood Hits	1103	Target Neighborhood Hits	537	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 1124)	NC score	0.067069 (rank : 1315)
Query Neighborhood Hits	1103	Target Neighborhood Hits	496	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AKA12_HUMAN
θ value	θ > 10 (rank : 1125)	NC score	0.074224 (rank : 1254)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	207
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

AKAP9_HUMAN
θ value	θ > 10 (rank : 1126)	NC score	0.062494 (rank : 1369)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1710	Shared Neighborhood Hits	215
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

AKT1_HUMAN
θ value	θ > 10 (rank : 1127)	NC score	0.450340 (rank : 676)
Query Neighborhood Hits	1103	Target Neighborhood Hits	885	Shared Neighborhood Hits	564
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	θ > 10 (rank : 1128)	NC score	0.449348 (rank : 679)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	564
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_HUMAN
θ value	θ > 10 (rank : 1129)	NC score	0.458375 (rank : 637)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	565
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	θ > 10 (rank : 1130)	NC score	0.457954 (rank : 639)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	563
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	θ > 10 (rank : 1131)	NC score	0.458462 (rank : 634)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	566
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	θ > 10 (rank : 1132)	NC score	0.458484 (rank : 633)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	566
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AMHR2_HUMAN
θ value	θ > 10 (rank : 1133)	NC score	0.467801 (rank : 593)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	488
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AN13B_HUMAN
θ value	θ > 10 (rank : 1134)	NC score	0.227241 (rank : 1065)
Query Neighborhood Hits	1103	Target Neighborhood Hits	265	Shared Neighborhood Hits	226
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	θ > 10 (rank : 1135)	NC score	0.228258 (rank : 1063)
Query Neighborhood Hits	1103	Target Neighborhood Hits	276	Shared Neighborhood Hits	229
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13C_HUMAN
θ value	θ > 10 (rank : 1136)	NC score	0.228233 (rank : 1064)
Query Neighborhood Hits	1103	Target Neighborhood Hits	241	Shared Neighborhood Hits	209
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13C_MOUSE
θ value	θ > 10 (rank : 1137)	NC score	0.222408 (rank : 1066)
Query Neighborhood Hits	1103	Target Neighborhood Hits	242	Shared Neighborhood Hits	207
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

ANKF1_HUMAN
θ value	θ > 10 (rank : 1138)	NC score	0.065203 (rank : 1342)
Query Neighborhood Hits	1103	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ANKR9_HUMAN
θ value	θ > 10 (rank : 1139)	NC score	0.107499 (rank : 1167)
Query Neighborhood Hits	1103	Target Neighborhood Hits	99	Shared Neighborhood Hits	89
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANKR9_MOUSE
θ value	θ > 10 (rank : 1140)	NC score	0.128501 (rank : 1133)
Query Neighborhood Hits	1103	Target Neighborhood Hits	120	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

ANM2_HUMAN
θ value	θ > 10 (rank : 1141)	NC score	0.070364 (rank : 1287)
Query Neighborhood Hits	1103	Target Neighborhood Hits	175	Shared Neighborhood Hits	42
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 1142)	NC score	0.065315 (rank : 1341)
Query Neighborhood Hits	1103	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANR22_HUMAN
θ value	θ > 10 (rank : 1143)	NC score	0.368207 (rank : 930)
Query Neighborhood Hits	1103	Target Neighborhood Hits	243	Shared Neighborhood Hits	215
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANR32_HUMAN
θ value	θ > 10 (rank : 1144)	NC score	0.334114 (rank : 983)
Query Neighborhood Hits	1103	Target Neighborhood Hits	270	Shared Neighborhood Hits	222
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR32_MOUSE
θ value	θ > 10 (rank : 1145)	NC score	0.327146 (rank : 992)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	222
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ANR33_HUMAN
θ value	θ > 10 (rank : 1146)	NC score	0.304419 (rank : 1012)
Query Neighborhood Hits	1103	Target Neighborhood Hits	215	Shared Neighborhood Hits	194
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR33_MOUSE
θ value	θ > 10 (rank : 1147)	NC score	0.309104 (rank : 1009)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	200
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

ANR38_MOUSE
θ value	θ > 10 (rank : 1148)	NC score	0.286089 (rank : 1024)
Query Neighborhood Hits	1103	Target Neighborhood Hits	512	Shared Neighborhood Hits	264
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

ANR40_HUMAN
θ value	θ > 10 (rank : 1149)	NC score	0.281316 (rank : 1027)
Query Neighborhood Hits	1103	Target Neighborhood Hits	224	Shared Neighborhood Hits	189
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR40_MOUSE
θ value	θ > 10 (rank : 1150)	NC score	0.277342 (rank : 1035)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	193
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR43_HUMAN
θ value	θ > 10 (rank : 1151)	NC score	0.271500 (rank : 1037)
Query Neighborhood Hits	1103	Target Neighborhood Hits	209	Shared Neighborhood Hits	184
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR43_MOUSE
θ value	θ > 10 (rank : 1152)	NC score	0.269990 (rank : 1038)
Query Neighborhood Hits	1103	Target Neighborhood Hits	214	Shared Neighborhood Hits	191
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

APS_HUMAN
θ value	θ > 10 (rank : 1153)	NC score	0.102758 (rank : 1169)
Query Neighborhood Hits	1103	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 1154)	NC score	0.079757 (rank : 1231)
Query Neighborhood Hits	1103	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARBK1_HUMAN
θ value	θ > 10 (rank : 1155)	NC score	0.414173 (rank : 770)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	553
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 1156)	NC score	0.410025 (rank : 792)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	554
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 1157)	NC score	0.408861 (rank : 800)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	552
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARHG6_HUMAN
θ value	θ > 10 (rank : 1158)	NC score	0.065099 (rank : 1343)
Query Neighborhood Hits	1103	Target Neighborhood Hits	376	Shared Neighborhood Hits	77
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 1159)	NC score	0.060674 (rank : 1400)
Query Neighborhood Hits	1103	Target Neighborhood Hits	394	Shared Neighborhood Hits	92
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 1160)	NC score	0.061127 (rank : 1391)
Query Neighborhood Hits	1103	Target Neighborhood Hits	347	Shared Neighborhood Hits	54
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 1161)	NC score	0.064792 (rank : 1345)
Query Neighborhood Hits	1103	Target Neighborhood Hits	396	Shared Neighborhood Hits	78
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ASB12_MOUSE
θ value	θ > 10 (rank : 1162)	NC score	0.379851 (rank : 906)
Query Neighborhood Hits	1103	Target Neighborhood Hits	261	Shared Neighborhood Hits	228
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB14_HUMAN
θ value	θ > 10 (rank : 1163)	NC score	0.257875 (rank : 1047)
Query Neighborhood Hits	1103	Target Neighborhood Hits	187	Shared Neighborhood Hits	168
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

AVR2A_HUMAN
θ value	θ > 10 (rank : 1164)	NC score	0.470750 (rank : 584)
Query Neighborhood Hits	1103	Target Neighborhood Hits	767	Shared Neighborhood Hits	543
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 1165)	NC score	0.470761 (rank : 583)
Query Neighborhood Hits	1103	Target Neighborhood Hits	767	Shared Neighborhood Hits	543
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 1166)	NC score	0.447152 (rank : 689)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	536
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 1167)	NC score	0.447426 (rank : 688)
Query Neighborhood Hits	1103	Target Neighborhood Hits	749	Shared Neighborhood Hits	536
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AZI1_HUMAN
θ value	θ > 10 (rank : 1168)	NC score	0.052955 (rank : 1545)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1000	Shared Neighborhood Hits	157
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BAT4_HUMAN
θ value	θ > 10 (rank : 1169)	NC score	0.118550 (rank : 1151)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BAT4_MOUSE
θ value	θ > 10 (rank : 1170)	NC score	0.127571 (rank : 1135)
Query Neighborhood Hits	1103	Target Neighborhood Hits	171	Shared Neighborhood Hits	112
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BLNK_HUMAN
θ value	θ > 10 (rank : 1171)	NC score	0.053205 (rank : 1541)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 1172)	NC score	0.057671 (rank : 1444)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMP2K_HUMAN
θ value	θ > 10 (rank : 1173)	NC score	0.432131 (rank : 717)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	544
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	θ > 10 (rank : 1174)	NC score	0.427853 (rank : 731)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	539
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMPR2_HUMAN
θ value	θ > 10 (rank : 1175)	NC score	0.489306 (rank : 466)
Query Neighborhood Hits	1103	Target Neighborhood Hits	736	Shared Neighborhood Hits	525
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 1176)	NC score	0.486298 (rank : 484)
Query Neighborhood Hits	1103	Target Neighborhood Hits	738	Shared Neighborhood Hits	524
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 1177)	NC score	0.514344 (rank : 348)
Query Neighborhood Hits	1103	Target Neighborhood Hits	759	Shared Neighborhood Hits	542
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 1178)	NC score	0.513234 (rank : 352)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	540
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 1179)	NC score	0.507962 (rank : 392)
Query Neighborhood Hits	1103	Target Neighborhood Hits	760	Shared Neighborhood Hits	537
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 1180)	NC score	0.509429 (rank : 382)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	538
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BOC_HUMAN
θ value	θ > 10 (rank : 1181)	NC score	0.060732 (rank : 1398)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BOC_MOUSE
θ value	θ > 10 (rank : 1182)	NC score	0.057559 (rank : 1448)
Query Neighborhood Hits	1103	Target Neighborhood Hits	433	Shared Neighborhood Hits	75
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BRE1A_HUMAN
θ value	θ > 10 (rank : 1183)	NC score	0.052824 (rank : 1547)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1071	Shared Neighborhood Hits	151
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1A_MOUSE
θ value	θ > 10 (rank : 1184)	NC score	0.050219 (rank : 1591)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1025	Shared Neighborhood Hits	140
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

BRSK1_HUMAN
θ value	θ > 10 (rank : 1185)	NC score	0.491643 (rank : 456)
Query Neighborhood Hits	1103	Target Neighborhood Hits	942	Shared Neighborhood Hits	573
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 1186)	NC score	0.495216 (rank : 444)
Query Neighborhood Hits	1103	Target Neighborhood Hits	897	Shared Neighborhood Hits	570
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BUB1_HUMAN
θ value	θ > 10 (rank : 1187)	NC score	0.159803 (rank : 1118)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	275
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

BUB1_MOUSE
θ value	θ > 10 (rank : 1188)	NC score	0.228385 (rank : 1062)
Query Neighborhood Hits	1103	Target Neighborhood Hits	583	Shared Neighborhood Hits	347
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

C8AP2_HUMAN
θ value	θ > 10 (rank : 1189)	NC score	0.052432 (rank : 1555)
Query Neighborhood Hits	1103	Target Neighborhood Hits	548	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CCD11_HUMAN
θ value	θ > 10 (rank : 1190)	NC score	0.063018 (rank : 1364)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	162
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD19_HUMAN
θ value	θ > 10 (rank : 1191)	NC score	0.052624 (rank : 1550)
Query Neighborhood Hits	1103	Target Neighborhood Hits	639	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD21_HUMAN
θ value	θ > 10 (rank : 1192)	NC score	0.059202 (rank : 1424)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1228	Shared Neighborhood Hits	210
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 1193)	NC score	0.059243 (rank : 1422)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1135	Shared Neighborhood Hits	202
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD39_HUMAN
θ value	θ > 10 (rank : 1194)	NC score	0.055449 (rank : 1496)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD39_MOUSE
θ value	θ > 10 (rank : 1195)	NC score	0.056960 (rank : 1465)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	156
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD41_HUMAN
θ value	θ > 10 (rank : 1196)	NC score	0.063799 (rank : 1352)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1139	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD41_MOUSE
θ value	θ > 10 (rank : 1197)	NC score	0.065726 (rank : 1332)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1399	Shared Neighborhood Hits	217
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CCD46_HUMAN
θ value	θ > 10 (rank : 1198)	NC score	0.066212 (rank : 1326)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1430	Shared Neighborhood Hits	213
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCD91_HUMAN
θ value	θ > 10 (rank : 1199)	NC score	0.054193 (rank : 1518)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	168
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CCD93_HUMAN
θ value	θ > 10 (rank : 1200)	NC score	0.051112 (rank : 1579)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	118
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCDC6_HUMAN
θ value	θ > 10 (rank : 1201)	NC score	0.050029 (rank : 1595)
Query Neighborhood Hits	1103	Target Neighborhood Hits	723	Shared Neighborhood Hits	136
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCHCR_MOUSE
θ value	θ > 10 (rank : 1202)	NC score	0.051189 (rank : 1577)
Query Neighborhood Hits	1103	Target Neighborhood Hits	932	Shared Neighborhood Hits	152
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CCRK_HUMAN
θ value	θ > 10 (rank : 1203)	NC score	0.461789 (rank : 620)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	561
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	θ > 10 (rank : 1204)	NC score	0.455252 (rank : 660)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD2A1_HUMAN
θ value	θ > 10 (rank : 1205)	NC score	0.279859 (rank : 1030)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	177
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

CD2AP_HUMAN
θ value	θ > 10 (rank : 1206)	NC score	0.067882 (rank : 1309)
Query Neighborhood Hits	1103	Target Neighborhood Hits	315	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 1207)	NC score	0.063180 (rank : 1362)
Query Neighborhood Hits	1103	Target Neighborhood Hits	336	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2L5_HUMAN
θ value	θ > 10 (rank : 1208)	NC score	0.488805 (rank : 468)
Query Neighborhood Hits	1103	Target Neighborhood Hits	987	Shared Neighborhood Hits	578
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 1209)	NC score	0.489600 (rank : 464)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1011	Shared Neighborhood Hits	588
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CDC2_HUMAN
θ value	θ > 10 (rank : 1210)	NC score	0.491723 (rank : 454)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	563
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 1211)	NC score	0.489635 (rank : 463)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	562
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC7_HUMAN
θ value	θ > 10 (rank : 1212)	NC score	0.287784 (rank : 1022)
Query Neighborhood Hits	1103	Target Neighborhood Hits	652	Shared Neighborhood Hits	398
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDC7_MOUSE
θ value	θ > 10 (rank : 1213)	NC score	0.273744 (rank : 1036)
Query Neighborhood Hits	1103	Target Neighborhood Hits	641	Shared Neighborhood Hits	394
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDK2_HUMAN
θ value	θ > 10 (rank : 1214)	NC score	0.482831 (rank : 501)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	560
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 1215)	NC score	0.482012 (rank : 507)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	556
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 1216)	NC score	0.488100 (rank : 474)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	560
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 1217)	NC score	0.483010 (rank : 500)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	558
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK5_HUMAN
θ value	θ > 10 (rank : 1218)	NC score	0.474481 (rank : 558)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	557
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 1219)	NC score	0.474812 (rank : 556)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	557
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK7_HUMAN
θ value	θ > 10 (rank : 1220)	NC score	0.473508 (rank : 565)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	560
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 1221)	NC score	0.474617 (rank : 557)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	560
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK9_HUMAN
θ value	θ > 10 (rank : 1222)	NC score	0.475868 (rank : 549)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	557
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 1223)	NC score	0.475185 (rank : 552)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	557
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDKL1_HUMAN
θ value	θ > 10 (rank : 1224)	NC score	0.462069 (rank : 615)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	561
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 1225)	NC score	0.457850 (rank : 640)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	558
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 1226)	NC score	0.479898 (rank : 530)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	561
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 1227)	NC score	0.479767 (rank : 531)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	562
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL4_HUMAN
θ value	θ > 10 (rank : 1228)	NC score	0.470082 (rank : 586)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	558
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 1229)	NC score	0.478151 (rank : 541)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	559
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 1230)	NC score	0.463562 (rank : 608)
Query Neighborhood Hits	1103	Target Neighborhood Hits	967	Shared Neighborhood Hits	586
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CDN2B_HUMAN
θ value	θ > 10 (rank : 1231)	NC score	0.282460 (rank : 1025)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	184
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

CDN2B_MOUSE
θ value	θ > 10 (rank : 1232)	NC score	0.296784 (rank : 1017)
Query Neighborhood Hits	1103	Target Neighborhood Hits	201	Shared Neighborhood Hits	186
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

CDN2C_HUMAN
θ value	θ > 10 (rank : 1233)	NC score	0.389311 (rank : 886)
Query Neighborhood Hits	1103	Target Neighborhood Hits	262	Shared Neighborhood Hits	230
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CDN2C_MOUSE
θ value	θ > 10 (rank : 1234)	NC score	0.391248 (rank : 877)
Query Neighborhood Hits	1103	Target Neighborhood Hits	270	Shared Neighborhood Hits	231
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CDON_HUMAN
θ value	θ > 10 (rank : 1235)	NC score	0.058496 (rank : 1435)
Query Neighborhood Hits	1103	Target Neighborhood Hits	412	Shared Neighborhood Hits	60
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_MOUSE
θ value	θ > 10 (rank : 1236)	NC score	0.055730 (rank : 1492)
Query Neighborhood Hits	1103	Target Neighborhood Hits	410	Shared Neighborhood Hits	61
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CE152_HUMAN
θ value	θ > 10 (rank : 1237)	NC score	0.058810 (rank : 1432)
Query Neighborhood Hits	1103	Target Neighborhood Hits	976	Shared Neighborhood Hits	156
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CENPJ_HUMAN
θ value	θ > 10 (rank : 1238)	NC score	0.050865 (rank : 1584)
Query Neighborhood Hits	1103	Target Neighborhood Hits	721	Shared Neighborhood Hits	165
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CEP35_HUMAN
θ value	θ > 10 (rank : 1239)	NC score	0.067532 (rank : 1312)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	192
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CEP63_HUMAN
θ value	θ > 10 (rank : 1240)	NC score	0.056859 (rank : 1468)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1005	Shared Neighborhood Hits	155
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 1241)	NC score	0.061062 (rank : 1394)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1270	Shared Neighborhood Hits	200
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CF152_HUMAN
θ value	θ > 10 (rank : 1242)	NC score	0.050872 (rank : 1583)
Query Neighborhood Hits	1103	Target Neighborhood Hits	704	Shared Neighborhood Hits	143
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CHIN_HUMAN
θ value	θ > 10 (rank : 1243)	NC score	0.059551 (rank : 1411)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1244)	NC score	0.060707 (rank : 1399)
Query Neighborhood Hits	1103	Target Neighborhood Hits	229	Shared Neighborhood Hits	59
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1245)	NC score	0.060000 (rank : 1404)
Query Neighborhood Hits	1103	Target Neighborhood Hits	220	Shared Neighborhood Hits	57
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHK1_HUMAN
θ value	θ > 10 (rank : 1246)	NC score	0.496453 (rank : 439)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	561
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 1247)	NC score	0.495952 (rank : 442)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	562
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHL1_HUMAN
θ value	θ > 10 (rank : 1248)	NC score	0.053673 (rank : 1532)
Query Neighborhood Hits	1103	Target Neighborhood Hits	413	Shared Neighborhood Hits	73
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CHL1_MOUSE
θ value	θ > 10 (rank : 1249)	NC score	0.052808 (rank : 1548)
Query Neighborhood Hits	1103	Target Neighborhood Hits	402	Shared Neighborhood Hits	69
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CI039_HUMAN
θ value	θ > 10 (rank : 1250)	NC score	0.073101 (rank : 1263)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1171	Shared Neighborhood Hits	200
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CI093_HUMAN
θ value	θ > 10 (rank : 1251)	NC score	0.053559 (rank : 1536)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1088	Shared Neighborhood Hits	177
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CING_HUMAN
θ value	θ > 10 (rank : 1252)	NC score	0.055413 (rank : 1497)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1275	Shared Neighborhood Hits	202
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CING_MOUSE
θ value	θ > 10 (rank : 1253)	NC score	0.059645 (rank : 1409)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1432	Shared Neighborhood Hits	215
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CJ118_MOUSE
θ value	θ > 10 (rank : 1254)	NC score	0.054118 (rank : 1522)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1132	Shared Neighborhood Hits	171
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CK5P2_HUMAN
θ value	θ > 10 (rank : 1255)	NC score	0.066849 (rank : 1320)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1433	Shared Neighborhood Hits	236
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CK5P2_MOUSE
θ value	θ > 10 (rank : 1256)	NC score	0.057595 (rank : 1447)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1151	Shared Neighborhood Hits	195
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CLK1_HUMAN
θ value	θ > 10 (rank : 1257)	NC score	0.353581 (rank : 958)
Query Neighborhood Hits	1103	Target Neighborhood Hits	756	Shared Neighborhood Hits	498
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
θ value	θ > 10 (rank : 1258)	NC score	0.356480 (rank : 951)
Query Neighborhood Hits	1103	Target Neighborhood Hits	760	Shared Neighborhood Hits	501
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK2_HUMAN
θ value	θ > 10 (rank : 1259)	NC score	0.340898 (rank : 971)
Query Neighborhood Hits	1103	Target Neighborhood Hits	752	Shared Neighborhood Hits	496
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK2_MOUSE
θ value	θ > 10 (rank : 1260)	NC score	0.330795 (rank : 990)
Query Neighborhood Hits	1103	Target Neighborhood Hits	743	Shared Neighborhood Hits	491
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK3_HUMAN
θ value	θ > 10 (rank : 1261)	NC score	0.335961 (rank : 978)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	494
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	θ > 10 (rank : 1262)	NC score	0.335734 (rank : 979)
Query Neighborhood Hits	1103	Target Neighborhood Hits	761	Shared Neighborhood Hits	495
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK4_HUMAN
θ value	θ > 10 (rank : 1263)	NC score	0.359725 (rank : 946)
Query Neighborhood Hits	1103	Target Neighborhood Hits	759	Shared Neighborhood Hits	508
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
θ value	θ > 10 (rank : 1264)	NC score	0.359663 (rank : 947)
Query Neighborhood Hits	1103	Target Neighborhood Hits	759	Shared Neighborhood Hits	508
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLR59_HUMAN
θ value	θ > 10 (rank : 1265)	NC score	0.137073 (rank : 1128)
Query Neighborhood Hits	1103	Target Neighborhood Hits	163	Shared Neighborhood Hits	134
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

CMTA1_HUMAN
θ value	θ > 10 (rank : 1266)	NC score	0.085590 (rank : 1213)
Query Neighborhood Hits	1103	Target Neighborhood Hits	217	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CMTA2_HUMAN
θ value	θ > 10 (rank : 1267)	NC score	0.066713 (rank : 1322)
Query Neighborhood Hits	1103	Target Neighborhood Hits	199	Shared Neighborhood Hits	90
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
θ value	θ > 10 (rank : 1268)	NC score	0.062395 (rank : 1371)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	85
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CN145_HUMAN
θ value	θ > 10 (rank : 1269)	NC score	0.062245 (rank : 1375)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1196	Shared Neighborhood Hits	185
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CN145_MOUSE
θ value	θ > 10 (rank : 1270)	NC score	0.057992 (rank : 1439)
Query Neighborhood Hits	1103	Target Neighborhood Hits	916	Shared Neighborhood Hits	140
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CNTN1_HUMAN
θ value	θ > 10 (rank : 1271)	NC score	0.051944 (rank : 1561)
Query Neighborhood Hits	1103	Target Neighborhood Hits	431	Shared Neighborhood Hits	69
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
θ value	θ > 10 (rank : 1272)	NC score	0.052774 (rank : 1549)
Query Neighborhood Hits	1103	Target Neighborhood Hits	422	Shared Neighborhood Hits	69
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN2_HUMAN
θ value	θ > 10 (rank : 1273)	NC score	0.065705 (rank : 1333)
Query Neighborhood Hits	1103	Target Neighborhood Hits	440	Shared Neighborhood Hits	81
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
θ value	θ > 10 (rank : 1274)	NC score	0.065435 (rank : 1339)
Query Neighborhood Hits	1103	Target Neighborhood Hits	450	Shared Neighborhood Hits	79
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN3_HUMAN
θ value	θ > 10 (rank : 1275)	NC score	0.062297 (rank : 1373)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	75
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN3_MOUSE
θ value	θ > 10 (rank : 1276)	NC score	0.058028 (rank : 1438)
Query Neighborhood Hits	1103	Target Neighborhood Hits	447	Shared Neighborhood Hits	73
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN4_HUMAN
θ value	θ > 10 (rank : 1277)	NC score	0.057045 (rank : 1463)
Query Neighborhood Hits	1103	Target Neighborhood Hits	449	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_MOUSE
θ value	θ > 10 (rank : 1278)	NC score	0.056181 (rank : 1482)
Query Neighborhood Hits	1103	Target Neighborhood Hits	445	Shared Neighborhood Hits	70
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN5_HUMAN
θ value	θ > 10 (rank : 1279)	NC score	0.067872 (rank : 1310)
Query Neighborhood Hits	1103	Target Neighborhood Hits	446	Shared Neighborhood Hits	79
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTN5_MOUSE
θ value	θ > 10 (rank : 1280)	NC score	0.059394 (rank : 1419)
Query Neighborhood Hits	1103	Target Neighborhood Hits	434	Shared Neighborhood Hits	74
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

CNTN6_HUMAN
θ value	θ > 10 (rank : 1281)	NC score	0.052571 (rank : 1551)
Query Neighborhood Hits	1103	Target Neighborhood Hits	422	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN6_MOUSE
θ value	θ > 10 (rank : 1282)	NC score	0.051429 (rank : 1569)
Query Neighborhood Hits	1103	Target Neighborhood Hits	429	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CNTRB_MOUSE
θ value	θ > 10 (rank : 1283)	NC score	0.057608 (rank : 1446)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1029	Shared Neighborhood Hits	183
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_HUMAN
θ value	θ > 10 (rank : 1284)	NC score	0.056402 (rank : 1477)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1290	Shared Neighborhood Hits	181
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP135_MOUSE
θ value	θ > 10 (rank : 1285)	NC score	0.061073 (rank : 1393)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1278	Shared Neighborhood Hits	183
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP250_HUMAN
θ value	θ > 10 (rank : 1286)	NC score	0.062343 (rank : 1372)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1805	Shared Neighborhood Hits	241
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CP250_MOUSE
θ value	θ > 10 (rank : 1287)	NC score	0.055743 (rank : 1491)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1583	Shared Neighborhood Hits	206
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CRKL_HUMAN
θ value	θ > 10 (rank : 1288)	NC score	0.133462 (rank : 1130)
Query Neighborhood Hits	1103	Target Neighborhood Hits	313	Shared Neighborhood Hits	63
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1289)	NC score	0.136163 (rank : 1129)
Query Neighborhood Hits	1103	Target Neighborhood Hits	307	Shared Neighborhood Hits	63
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1290)	NC score	0.118301 (rank : 1152)
Query Neighborhood Hits	1103	Target Neighborhood Hits	308	Shared Neighborhood Hits	63
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1291)	NC score	0.116016 (rank : 1157)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CROCC_MOUSE
θ value	θ > 10 (rank : 1292)	NC score	0.054902 (rank : 1508)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1460	Shared Neighborhood Hits	203
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CSK21_HUMAN
θ value	θ > 10 (rank : 1293)	NC score	0.386748 (rank : 895)
Query Neighborhood Hits	1103	Target Neighborhood Hits	772	Shared Neighborhood Hits	509
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	θ > 10 (rank : 1294)	NC score	0.387516 (rank : 892)
Query Neighborhood Hits	1103	Target Neighborhood Hits	770	Shared Neighborhood Hits	509
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	θ > 10 (rank : 1295)	NC score	0.367192 (rank : 937)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	501
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
θ value	θ > 10 (rank : 1296)	NC score	0.368420 (rank : 928)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	501
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CT012_HUMAN
θ value	θ > 10 (rank : 1297)	NC score	0.185478 (rank : 1101)
Query Neighborhood Hits	1103	Target Neighborhood Hits	205	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

CT012_MOUSE
θ value	θ > 10 (rank : 1298)	NC score	0.212291 (rank : 1072)
Query Neighborhood Hits	1103	Target Neighborhood Hits	229	Shared Neighborhood Hits	171
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

CT2NL_HUMAN
θ value	θ > 10 (rank : 1299)	NC score	0.066754 (rank : 1321)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1059	Shared Neighborhood Hits	198
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
θ value	θ > 10 (rank : 1300)	NC score	0.063309 (rank : 1360)
Query Neighborhood Hits	1103	Target Neighborhood Hits	902	Shared Neighborhood Hits	184
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CU081_HUMAN
θ value	θ > 10 (rank : 1301)	NC score	0.073986 (rank : 1256)
Query Neighborhood Hits	1103	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

CYLN2_HUMAN
θ value	θ > 10 (rank : 1302)	NC score	0.051508 (rank : 1568)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1004	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

DAPP1_HUMAN
θ value	θ > 10 (rank : 1303)	NC score	0.126999 (rank : 1137)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1304)	NC score	0.123936 (rank : 1140)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCAK3_MOUSE
θ value	θ > 10 (rank : 1305)	NC score	0.478093 (rank : 542)
Query Neighborhood Hits	1103	Target Neighborhood Hits	922	Shared Neighborhood Hits	589
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DCC_HUMAN
θ value	θ > 10 (rank : 1306)	NC score	0.083405 (rank : 1219)
Query Neighborhood Hits	1103	Target Neighborhood Hits	583	Shared Neighborhood Hits	95
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	θ > 10 (rank : 1307)	NC score	0.084050 (rank : 1215)
Query Neighborhood Hits	1103	Target Neighborhood Hits	896	Shared Neighborhood Hits	134
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DDEF1_MOUSE
θ value	θ > 10 (rank : 1308)	NC score	0.137318 (rank : 1127)
Query Neighborhood Hits	1103	Target Neighborhood Hits	592	Shared Neighborhood Hits	227
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 1309)	NC score	0.177880 (rank : 1107)
Query Neighborhood Hits	1103	Target Neighborhood Hits	599	Shared Neighborhood Hits	250
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 1310)	NC score	0.177347 (rank : 1108)
Query Neighborhood Hits	1103	Target Neighborhood Hits	625	Shared Neighborhood Hits	260
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_HUMAN
θ value	θ > 10 (rank : 1311)	NC score	0.160747 (rank : 1117)
Query Neighborhood Hits	1103	Target Neighborhood Hits	353	Shared Neighborhood Hits	224
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	θ > 10 (rank : 1312)	NC score	0.199954 (rank : 1083)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	227
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DESP_HUMAN
θ value	θ > 10 (rank : 1313)	NC score	0.061618 (rank : 1387)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1470	Shared Neighborhood Hits	215
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DGKD_HUMAN
θ value	θ > 10 (rank : 1314)	NC score	0.080508 (rank : 1229)
Query Neighborhood Hits	1103	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1315)	NC score	0.066433 (rank : 1323)
Query Neighborhood Hits	1103	Target Neighborhood Hits	255	Shared Neighborhood Hits	77
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DMP1_MOUSE
θ value	θ > 10 (rank : 1316)	NC score	0.064689 (rank : 1346)
Query Neighborhood Hits	1103	Target Neighborhood Hits	498	Shared Neighborhood Hits	118
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

DNMBP_HUMAN
θ value	θ > 10 (rank : 1317)	NC score	0.069812 (rank : 1291)
Query Neighborhood Hits	1103	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DSCAM_HUMAN
θ value	θ > 10 (rank : 1318)	NC score	0.076902 (rank : 1240)
Query Neighborhood Hits	1103	Target Neighborhood Hits	524	Shared Neighborhood Hits	82
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
θ value	θ > 10 (rank : 1319)	NC score	0.080545 (rank : 1228)
Query Neighborhood Hits	1103	Target Neighborhood Hits	589	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DUET_HUMAN
θ value	θ > 10 (rank : 1320)	NC score	0.409459 (rank : 797)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1220	Shared Neighborhood Hits	563
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYR1A_HUMAN
θ value	θ > 10 (rank : 1321)	NC score	0.363866 (rank : 942)
Query Neighborhood Hits	1103	Target Neighborhood Hits	764	Shared Neighborhood Hits	509
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 1322)	NC score	0.363864 (rank : 943)
Query Neighborhood Hits	1103	Target Neighborhood Hits	762	Shared Neighborhood Hits	509
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 1323)	NC score	0.375545 (rank : 918)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	526
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1B_MOUSE
θ value	θ > 10 (rank : 1324)	NC score	0.375683 (rank : 917)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	524
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYRK2_HUMAN
θ value	θ > 10 (rank : 1325)	NC score	0.377919 (rank : 911)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	525
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DYRK3_HUMAN
θ value	θ > 10 (rank : 1326)	NC score	0.397292 (rank : 847)
Query Neighborhood Hits	1103	Target Neighborhood Hits	798	Shared Neighborhood Hits	530
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

DYRK4_HUMAN
θ value	θ > 10 (rank : 1327)	NC score	0.352062 (rank : 962)
Query Neighborhood Hits	1103	Target Neighborhood Hits	750	Shared Neighborhood Hits	503
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

E2AK4_HUMAN
θ value	θ > 10 (rank : 1328)	NC score	0.484183 (rank : 492)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1012	Shared Neighborhood Hits	598
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

E2AK4_MOUSE
θ value	θ > 10 (rank : 1329)	NC score	0.473984 (rank : 561)
Query Neighborhood Hits	1103	Target Neighborhood Hits	984	Shared Neighborhood Hits	586
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

EEA1_HUMAN
θ value	θ > 10 (rank : 1330)	NC score	0.054966 (rank : 1506)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1796	Shared Neighborhood Hits	219
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 1331)	NC score	0.056700 (rank : 1470)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1637	Shared Neighborhood Hits	224
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EP15R_HUMAN
θ value	θ > 10 (rank : 1332)	NC score	0.057136 (rank : 1462)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1083	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 1333)	NC score	0.058846 (rank : 1431)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1135	Shared Neighborhood Hits	195
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

ERC2_HUMAN
θ value	θ > 10 (rank : 1334)	NC score	0.052529 (rank : 1553)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1156	Shared Neighborhood Hits	168
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	θ > 10 (rank : 1335)	NC score	0.054248 (rank : 1516)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1166	Shared Neighborhood Hits	171
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ERN1_MOUSE
θ value	θ > 10 (rank : 1336)	NC score	0.487020 (rank : 481)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	548
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_HUMAN
θ value	θ > 10 (rank : 1337)	NC score	0.455220 (rank : 661)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	549
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_MOUSE
θ value	θ > 10 (rank : 1338)	NC score	0.455569 (rank : 656)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	544
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ES8L1_HUMAN
θ value	θ > 10 (rank : 1339)	NC score	0.061642 (rank : 1385)
Query Neighborhood Hits	1103	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 1340)	NC score	0.065536 (rank : 1335)
Query Neighborhood Hits	1103	Target Neighborhood Hits	193	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 1341)	NC score	0.066940 (rank : 1319)
Query Neighborhood Hits	1103	Target Neighborhood Hits	169	Shared Neighborhood Hits	42
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 1342)	NC score	0.093818 (rank : 1187)
Query Neighborhood Hits	1103	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 1343)	NC score	0.079647 (rank : 1233)
Query Neighborhood Hits	1103	Target Neighborhood Hits	168	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

F5006_HUMAN
θ value	θ > 10 (rank : 1344)	NC score	0.398949 (rank : 839)
Query Neighborhood Hits	1103	Target Neighborhood Hits	794	Shared Neighborhood Hits	534
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	θ > 10 (rank : 1345)	NC score	0.416480 (rank : 763)
Query Neighborhood Hits	1103	Target Neighborhood Hits	793	Shared Neighborhood Hits	542
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FGRL1_HUMAN
θ value	θ > 10 (rank : 1346)	NC score	0.070478 (rank : 1285)
Query Neighborhood Hits	1103	Target Neighborhood Hits	335	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

FGRL1_MOUSE
θ value	θ > 10 (rank : 1347)	NC score	0.073236 (rank : 1262)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

FLIP1_HUMAN
θ value	θ > 10 (rank : 1348)	NC score	0.059389 (rank : 1420)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1405	Shared Neighborhood Hits	206
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_MOUSE
θ value	θ > 10 (rank : 1349)	NC score	0.057898 (rank : 1441)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1176	Shared Neighborhood Hits	189
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FNDC3_HUMAN
θ value	θ > 10 (rank : 1350)	NC score	0.071000 (rank : 1284)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	θ > 10 (rank : 1351)	NC score	0.071834 (rank : 1277)
Query Neighborhood Hits	1103	Target Neighborhood Hits	207	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

GAK_HUMAN
θ value	θ > 10 (rank : 1352)	NC score	0.441447 (rank : 701)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1028	Shared Neighborhood Hits	564
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	θ > 10 (rank : 1353)	NC score	0.428512 (rank : 728)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	552
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAS8_HUMAN
θ value	θ > 10 (rank : 1354)	NC score	0.056687 (rank : 1471)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	142
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GCC2_HUMAN
θ value	θ > 10 (rank : 1355)	NC score	0.057188 (rank : 1461)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1558	Shared Neighborhood Hits	206
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GLSK_HUMAN
θ value	θ > 10 (rank : 1356)	NC score	0.205548 (rank : 1080)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	170
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

GLSL_HUMAN
θ value	θ > 10 (rank : 1357)	NC score	0.218132 (rank : 1067)
Query Neighborhood Hits	1103	Target Neighborhood Hits	211	Shared Neighborhood Hits	181
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

GLSL_MOUSE
θ value	θ > 10 (rank : 1358)	NC score	0.211659 (rank : 1074)
Query Neighborhood Hits	1103	Target Neighborhood Hits	212	Shared Neighborhood Hits	178
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

GOGA1_HUMAN
θ value	θ > 10 (rank : 1359)	NC score	0.059421 (rank : 1417)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1222	Shared Neighborhood Hits	179
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA1_MOUSE
θ value	θ > 10 (rank : 1360)	NC score	0.050720 (rank : 1587)
Query Neighborhood Hits	1103	Target Neighborhood Hits	994	Shared Neighborhood Hits	158
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA3_HUMAN
θ value	θ > 10 (rank : 1361)	NC score	0.052150 (rank : 1559)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1317	Shared Neighborhood Hits	189
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	θ > 10 (rank : 1362)	NC score	0.052558 (rank : 1552)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1437	Shared Neighborhood Hits	195
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA5_HUMAN
θ value	θ > 10 (rank : 1363)	NC score	0.053747 (rank : 1530)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1168	Shared Neighborhood Hits	177
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

GOGA5_MOUSE
θ value	θ > 10 (rank : 1364)	NC score	0.063318 (rank : 1359)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1434	Shared Neighborhood Hits	224
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GRAP1_MOUSE
θ value	θ > 10 (rank : 1365)	NC score	0.059820 (rank : 1406)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1234	Shared Neighborhood Hits	186
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1366)	NC score	0.194351 (rank : 1091)
Query Neighborhood Hits	1103	Target Neighborhood Hits	304	Shared Neighborhood Hits	63
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1367)	NC score	0.191745 (rank : 1095)
Query Neighborhood Hits	1103	Target Neighborhood Hits	297	Shared Neighborhood Hits	61
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1368)	NC score	0.199623 (rank : 1084)
Query Neighborhood Hits	1103	Target Neighborhood Hits	307	Shared Neighborhood Hits	68
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1369)	NC score	0.200316 (rank : 1082)
Query Neighborhood Hits	1103	Target Neighborhood Hits	309	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB10_HUMAN
θ value	θ > 10 (rank : 1370)	NC score	0.081626 (rank : 1222)
Query Neighborhood Hits	1103	Target Neighborhood Hits	147	Shared Neighborhood Hits	48
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 1371)	NC score	0.082115 (rank : 1220)
Query Neighborhood Hits	1103	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 1372)	NC score	0.109368 (rank : 1166)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1373)	NC score	0.116041 (rank : 1156)
Query Neighborhood Hits	1103	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1374)	NC score	0.192833 (rank : 1093)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	64
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1375)	NC score	0.192712 (rank : 1094)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	64
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_HUMAN
θ value	θ > 10 (rank : 1376)	NC score	0.094910 (rank : 1186)
Query Neighborhood Hits	1103	Target Neighborhood Hits	156	Shared Neighborhood Hits	42
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 1377)	NC score	0.101951 (rank : 1171)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRK4_HUMAN
θ value	θ > 10 (rank : 1378)	NC score	0.453941 (rank : 666)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	547
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 1379)	NC score	0.458258 (rank : 638)
Query Neighborhood Hits	1103	Target Neighborhood Hits	808	Shared Neighborhood Hits	540
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 1380)	NC score	0.448650 (rank : 685)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	544
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 1381)	NC score	0.448800 (rank : 683)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	544
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 1382)	NC score	0.456883 (rank : 645)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	551
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 1383)	NC score	0.457460 (rank : 643)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	550
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 1384)	NC score	0.428180 (rank : 730)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	548
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GSK3B_HUMAN
θ value	θ > 10 (rank : 1385)	NC score	0.427380 (rank : 733)
Query Neighborhood Hits	1103	Target Neighborhood Hits	801	Shared Neighborhood Hits	537
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 1386)	NC score	0.426821 (rank : 735)
Query Neighborhood Hits	1103	Target Neighborhood Hits	800	Shared Neighborhood Hits	536
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GUC2G_MOUSE
θ value	θ > 10 (rank : 1387)	NC score	0.488488 (rank : 472)
Query Neighborhood Hits	1103	Target Neighborhood Hits	644	Shared Neighborhood Hits	451
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCLS1_HUMAN
θ value	θ > 10 (rank : 1388)	NC score	0.057855 (rank : 1442)
Query Neighborhood Hits	1103	Target Neighborhood Hits	358	Shared Neighborhood Hits	73
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 1389)	NC score	0.059010 (rank : 1427)
Query Neighborhood Hits	1103	Target Neighborhood Hits	329	Shared Neighborhood Hits	65
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HIPK1_HUMAN
θ value	θ > 10 (rank : 1390)	NC score	0.402126 (rank : 825)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	539
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	θ > 10 (rank : 1391)	NC score	0.401543 (rank : 829)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	540
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK2_HUMAN
θ value	θ > 10 (rank : 1392)	NC score	0.395914 (rank : 850)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	541
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	θ > 10 (rank : 1393)	NC score	0.396997 (rank : 848)
Query Neighborhood Hits	1103	Target Neighborhood Hits	871	Shared Neighborhood Hits	547
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HIPK3_HUMAN
θ value	θ > 10 (rank : 1394)	NC score	0.407789 (rank : 806)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	554
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	θ > 10 (rank : 1395)	NC score	0.407909 (rank : 805)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	547
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK4_HUMAN
θ value	θ > 10 (rank : 1396)	NC score	0.429840 (rank : 723)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	532
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

HMMR_HUMAN
θ value	θ > 10 (rank : 1397)	NC score	0.050961 (rank : 1581)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1082	Shared Neighborhood Hits	149
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

HMMR_MOUSE
θ value	θ > 10 (rank : 1398)	NC score	0.053909 (rank : 1527)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1178	Shared Neighborhood Hits	174
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HOME2_MOUSE
θ value	θ > 10 (rank : 1399)	NC score	0.050765 (rank : 1586)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	164
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

HSH2D_HUMAN
θ value	θ > 10 (rank : 1400)	NC score	0.121614 (rank : 1142)
Query Neighborhood Hits	1103	Target Neighborhood Hits	159	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 1401)	NC score	0.066972 (rank : 1317)
Query Neighborhood Hits	1103	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IFT74_HUMAN
θ value	θ > 10 (rank : 1402)	NC score	0.055141 (rank : 1503)
Query Neighborhood Hits	1103	Target Neighborhood Hits	949	Shared Neighborhood Hits	145
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_HUMAN
θ value	θ > 10 (rank : 1403)	NC score	0.056611 (rank : 1473)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	153
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IFT81_MOUSE
θ value	θ > 10 (rank : 1404)	NC score	0.059209 (rank : 1423)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	157
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

INCE_MOUSE
θ value	θ > 10 (rank : 1405)	NC score	0.061626 (rank : 1386)
Query Neighborhood Hits	1103	Target Neighborhood Hits	903	Shared Neighborhood Hits	147
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INVO_MOUSE
θ value	θ > 10 (rank : 1406)	NC score	0.051346 (rank : 1571)
Query Neighborhood Hits	1103	Target Neighborhood Hits	474	Shared Neighborhood Hits	110
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

IRAK2_HUMAN
θ value	θ > 10 (rank : 1407)	NC score	0.522871 (rank : 315)
Query Neighborhood Hits	1103	Target Neighborhood Hits	714	Shared Neighborhood Hits	502
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ITB4_HUMAN
θ value	θ > 10 (rank : 1408)	NC score	0.050885 (rank : 1582)
Query Neighborhood Hits	1103	Target Neighborhood Hits	458	Shared Neighborhood Hits	56
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

ITSN1_HUMAN
θ value	θ > 10 (rank : 1409)	NC score	0.093039 (rank : 1191)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1757	Shared Neighborhood Hits	271
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 1410)	NC score	0.096566 (rank : 1182)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1669	Shared Neighborhood Hits	276
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 1411)	NC score	0.088024 (rank : 1210)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1173	Shared Neighborhood Hits	178
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 1412)	NC score	0.089168 (rank : 1206)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1371	Shared Neighborhood Hits	221
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

K0555_HUMAN
θ value	θ > 10 (rank : 1413)	NC score	0.062286 (rank : 1374)
Query Neighborhood Hits	1103	Target Neighborhood Hits	880	Shared Neighborhood Hits	153
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

K2002_HUMAN
θ value	θ > 10 (rank : 1414)	NC score	0.139211 (rank : 1126)
Query Neighborhood Hits	1103	Target Neighborhood Hits	274	Shared Neighborhood Hits	179
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
θ value	θ > 10 (rank : 1415)	NC score	0.121416 (rank : 1144)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	163
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KC1AL_HUMAN
θ value	θ > 10 (rank : 1416)	NC score	0.343230 (rank : 968)
Query Neighborhood Hits	1103	Target Neighborhood Hits	734	Shared Neighborhood Hits	490
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1A_HUMAN
θ value	θ > 10 (rank : 1417)	NC score	0.341850 (rank : 969)
Query Neighborhood Hits	1103	Target Neighborhood Hits	728	Shared Neighborhood Hits	494
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	θ > 10 (rank : 1418)	NC score	0.341850 (rank : 970)
Query Neighborhood Hits	1103	Target Neighborhood Hits	728	Shared Neighborhood Hits	494
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1D_HUMAN
θ value	θ > 10 (rank : 1419)	NC score	0.374180 (rank : 922)
Query Neighborhood Hits	1103	Target Neighborhood Hits	737	Shared Neighborhood Hits	492
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 1420)	NC score	0.374167 (rank : 923)
Query Neighborhood Hits	1103	Target Neighborhood Hits	737	Shared Neighborhood Hits	492
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 1421)	NC score	0.367200 (rank : 936)
Query Neighborhood Hits	1103	Target Neighborhood Hits	732	Shared Neighborhood Hits	490
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 1422)	NC score	0.367226 (rank : 935)
Query Neighborhood Hits	1103	Target Neighborhood Hits	728	Shared Neighborhood Hits	490
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G1_HUMAN
θ value	θ > 10 (rank : 1423)	NC score	0.333631 (rank : 985)
Query Neighborhood Hits	1103	Target Neighborhood Hits	708	Shared Neighborhood Hits	472
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	θ > 10 (rank : 1424)	NC score	0.333977 (rank : 984)
Query Neighborhood Hits	1103	Target Neighborhood Hits	713	Shared Neighborhood Hits	474
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G3_HUMAN
θ value	θ > 10 (rank : 1425)	NC score	0.331343 (rank : 989)
Query Neighborhood Hits	1103	Target Neighborhood Hits	711	Shared Neighborhood Hits	475
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KCC2A_HUMAN
θ value	θ > 10 (rank : 1426)	NC score	0.457269 (rank : 644)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	555
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	θ > 10 (rank : 1427)	NC score	0.454338 (rank : 664)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	553
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2D_HUMAN
θ value	θ > 10 (rank : 1428)	NC score	0.455370 (rank : 659)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	554
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KKCC1_HUMAN
θ value	θ > 10 (rank : 1429)	NC score	0.477655 (rank : 544)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	563
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 1430)	NC score	0.477831 (rank : 543)
Query Neighborhood Hits	1103	Target Neighborhood Hits	866	Shared Neighborhood Hits	562
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 1431)	NC score	0.486001 (rank : 488)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	563
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 1432)	NC score	0.486083 (rank : 487)
Query Neighborhood Hits	1103	Target Neighborhood Hits	855	Shared Neighborhood Hits	563
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KMHN1_HUMAN
θ value	θ > 10 (rank : 1433)	NC score	0.056216 (rank : 1481)
Query Neighborhood Hits	1103	Target Neighborhood Hits	950	Shared Neighborhood Hits	162
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KMHN1_MOUSE
θ value	θ > 10 (rank : 1434)	NC score	0.056270 (rank : 1480)
Query Neighborhood Hits	1103	Target Neighborhood Hits	949	Shared Neighborhood Hits	151
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

KPCB_HUMAN
θ value	θ > 10 (rank : 1435)	NC score	0.467440 (rank : 595)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1121	Shared Neighborhood Hits	560
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 1436)	NC score	0.468524 (rank : 589)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1117	Shared Neighborhood Hits	560
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KRIT1_HUMAN
θ value	θ > 10 (rank : 1437)	NC score	0.290392 (rank : 1020)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	199
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

KRIT1_MOUSE
θ value	θ > 10 (rank : 1438)	NC score	0.306582 (rank : 1010)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	206
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

KS6C1_HUMAN
θ value	θ > 10 (rank : 1439)	NC score	0.280381 (rank : 1029)
Query Neighborhood Hits	1103	Target Neighborhood Hits	682	Shared Neighborhood Hits	417
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 1440)	NC score	0.287022 (rank : 1023)
Query Neighborhood Hits	1103	Target Neighborhood Hits	700	Shared Neighborhood Hits	421
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSR1_HUMAN
θ value	θ > 10 (rank : 1441)	NC score	0.610220 (rank : 209)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	563
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KTN1_HUMAN
θ value	θ > 10 (rank : 1442)	NC score	0.052370 (rank : 1556)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1197	Shared Neighborhood Hits	174
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

KTN1_MOUSE
θ value	θ > 10 (rank : 1443)	NC score	0.058141 (rank : 1437)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1324	Shared Neighborhood Hits	197
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

L1CAM_HUMAN
θ value	θ > 10 (rank : 1444)	NC score	0.076811 (rank : 1242)
Query Neighborhood Hits	1103	Target Neighborhood Hits	457	Shared Neighborhood Hits	85
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
θ value	θ > 10 (rank : 1445)	NC score	0.071890 (rank : 1275)
Query Neighborhood Hits	1103	Target Neighborhood Hits	457	Shared Neighborhood Hits	85
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LAD1_MOUSE
θ value	θ > 10 (rank : 1446)	NC score	0.050463 (rank : 1590)
Query Neighborhood Hits	1103	Target Neighborhood Hits	391	Shared Neighborhood Hits	112
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LATS1_HUMAN
θ value	θ > 10 (rank : 1447)	NC score	0.400657 (rank : 834)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1057	Shared Neighborhood Hits	597
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	θ > 10 (rank : 1448)	NC score	0.398166 (rank : 842)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1027	Shared Neighborhood Hits	589
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 1449)	NC score	0.393676 (rank : 867)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	558
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 1450)	NC score	0.392994 (rank : 869)
Query Neighborhood Hits	1103	Target Neighborhood Hits	879	Shared Neighborhood Hits	560
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

LCP2_HUMAN
θ value	θ > 10 (rank : 1451)	NC score	0.072561 (rank : 1269)
Query Neighborhood Hits	1103	Target Neighborhood Hits	531	Shared Neighborhood Hits	95
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 1452)	NC score	0.062659 (rank : 1367)
Query Neighborhood Hits	1103	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LIPA1_HUMAN
θ value	θ > 10 (rank : 1453)	NC score	0.055667 (rank : 1494)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1294	Shared Neighborhood Hits	214
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

LIPA2_MOUSE
θ value	θ > 10 (rank : 1454)	NC score	0.053729 (rank : 1531)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1282	Shared Neighborhood Hits	215
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LNK_HUMAN
θ value	θ > 10 (rank : 1455)	NC score	0.096831 (rank : 1181)
Query Neighborhood Hits	1103	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 1456)	NC score	0.089068 (rank : 1208)
Query Neighborhood Hits	1103	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC45_MOUSE
θ value	θ > 10 (rank : 1457)	NC score	0.053444 (rank : 1537)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRRF1_HUMAN
θ value	θ > 10 (rank : 1458)	NC score	0.058990 (rank : 1428)
Query Neighborhood Hits	1103	Target Neighborhood Hits	625	Shared Neighborhood Hits	150
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LSAMP_HUMAN
θ value	θ > 10 (rank : 1459)	NC score	0.053608 (rank : 1534)
Query Neighborhood Hits	1103	Target Neighborhood Hits	347	Shared Neighborhood Hits	46
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_MOUSE
θ value	θ > 10 (rank : 1460)	NC score	0.052980 (rank : 1544)
Query Neighborhood Hits	1103	Target Neighborhood Hits	344	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

LUZP1_MOUSE
θ value	θ > 10 (rank : 1461)	NC score	0.053916 (rank : 1526)
Query Neighborhood Hits	1103	Target Neighborhood Hits	940	Shared Neighborhood Hits	171
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

M3K5_HUMAN
θ value	θ > 10 (rank : 1462)	NC score	0.517133 (rank : 336)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	570
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 1463)	NC score	0.517227 (rank : 335)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	565
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 1464)	NC score	0.517555 (rank : 333)
Query Neighborhood Hits	1103	Target Neighborhood Hits	889	Shared Neighborhood Hits	568
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M4K1_MOUSE
θ value	θ > 10 (rank : 1465)	NC score	0.511037 (rank : 368)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	568
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 1466)	NC score	0.498006 (rank : 434)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	566
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 1467)	NC score	0.499830 (rank : 427)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	565
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 1468)	NC score	0.505197 (rank : 406)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	572
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K5_HUMAN
θ value	θ > 10 (rank : 1469)	NC score	0.493481 (rank : 448)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	566
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	θ > 10 (rank : 1470)	NC score	0.493396 (rank : 449)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	563
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAPK5_HUMAN
θ value	θ > 10 (rank : 1471)	NC score	0.394417 (rank : 861)
Query Neighborhood Hits	1103	Target Neighborhood Hits	795	Shared Neighborhood Hits	520
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 1472)	NC score	0.397308 (rank : 845)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	525
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MD1L1_MOUSE
θ value	θ > 10 (rank : 1473)	NC score	0.051934 (rank : 1562)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1001	Shared Neighborhood Hits	153
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MDC1_HUMAN
θ value	θ > 10 (rank : 1474)	NC score	0.051369 (rank : 1570)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1446	Shared Neighborhood Hits	232
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MK04_HUMAN
θ value	θ > 10 (rank : 1475)	NC score	0.471755 (rank : 577)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	552
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 1476)	NC score	0.468506 (rank : 590)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	552
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 1477)	NC score	0.455823 (rank : 654)
Query Neighborhood Hits	1103	Target Neighborhood Hits	815	Shared Neighborhood Hits	540
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 1478)	NC score	0.455669 (rank : 655)
Query Neighborhood Hits	1103	Target Neighborhood Hits	818	Shared Neighborhood Hits	542
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK15_HUMAN
θ value	θ > 10 (rank : 1479)	NC score	0.461892 (rank : 617)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1038	Shared Neighborhood Hits	588
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK15_MOUSE
θ value	θ > 10 (rank : 1480)	NC score	0.446833 (rank : 690)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	558
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MKNK1_HUMAN
θ value	θ > 10 (rank : 1481)	NC score	0.333111 (rank : 986)
Query Neighborhood Hits	1103	Target Neighborhood Hits	701	Shared Neighborhood Hits	440
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MOK_MOUSE
θ value	θ > 10 (rank : 1482)	NC score	0.442533 (rank : 699)
Query Neighborhood Hits	1103	Target Neighborhood Hits	796	Shared Neighborhood Hits	528
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MP2K1_HUMAN
θ value	θ > 10 (rank : 1483)	NC score	0.511133 (rank : 366)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	558
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 1484)	NC score	0.511149 (rank : 365)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	558
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 1485)	NC score	0.517077 (rank : 337)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	561
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 1486)	NC score	0.514414 (rank : 347)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	560
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 1487)	NC score	0.501604 (rank : 423)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	555
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 1488)	NC score	0.502916 (rank : 417)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	555
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 1489)	NC score	0.508210 (rank : 388)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	564
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 1490)	NC score	0.508137 (rank : 390)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	564
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 1491)	NC score	0.529995 (rank : 282)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	562
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 1492)	NC score	0.534343 (rank : 273)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	564
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MRCKA_HUMAN
θ value	θ > 10 (rank : 1493)	NC score	0.404735 (rank : 816)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1999	Shared Neighborhood Hits	703
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKB_HUMAN
θ value	θ > 10 (rank : 1494)	NC score	0.394346 (rank : 862)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2239	Shared Neighborhood Hits	730
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_MOUSE
θ value	θ > 10 (rank : 1495)	NC score	0.397689 (rank : 844)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2180	Shared Neighborhood Hits	723
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MY18A_HUMAN
θ value	θ > 10 (rank : 1496)	NC score	0.062074 (rank : 1380)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1929	Shared Neighborhood Hits	281
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	θ > 10 (rank : 1497)	NC score	0.064451 (rank : 1347)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1989	Shared Neighborhood Hits	294
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYO3B_HUMAN
θ value	θ > 10 (rank : 1498)	NC score	0.439516 (rank : 706)
Query Neighborhood Hits	1103	Target Neighborhood Hits	923	Shared Neighborhood Hits	577
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

MYOM1_HUMAN
θ value	θ > 10 (rank : 1499)	NC score	0.081295 (rank : 1225)
Query Neighborhood Hits	1103	Target Neighborhood Hits	405	Shared Neighborhood Hits	96
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
θ value	θ > 10 (rank : 1500)	NC score	0.075841 (rank : 1248)
Query Neighborhood Hits	1103	Target Neighborhood Hits	415	Shared Neighborhood Hits	85
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
θ value	θ > 10 (rank : 1501)	NC score	0.073255 (rank : 1261)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOTI_HUMAN
θ value	θ > 10 (rank : 1502)	NC score	0.055840 (rank : 1489)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
θ value	θ > 10 (rank : 1503)	NC score	0.051709 (rank : 1565)
Query Neighborhood Hits	1103	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC3_HUMAN
θ value	θ > 10 (rank : 1504)	NC score	0.059495 (rank : 1414)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	65
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_MOUSE
θ value	θ > 10 (rank : 1505)	NC score	0.062873 (rank : 1366)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	62
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPN_HUMAN
θ value	θ > 10 (rank : 1506)	NC score	0.056596 (rank : 1475)
Query Neighborhood Hits	1103	Target Neighborhood Hits	418	Shared Neighborhood Hits	66
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MYPN_MOUSE
θ value	θ > 10 (rank : 1507)	NC score	0.057460 (rank : 1450)
Query Neighborhood Hits	1103	Target Neighborhood Hits	421	Shared Neighborhood Hits	62
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NCA11_HUMAN
θ value	θ > 10 (rank : 1508)	NC score	0.063550 (rank : 1355)
Query Neighborhood Hits	1103	Target Neighborhood Hits	443	Shared Neighborhood Hits	67
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA11_MOUSE
θ value	θ > 10 (rank : 1509)	NC score	0.062196 (rank : 1376)
Query Neighborhood Hits	1103	Target Neighborhood Hits	661	Shared Neighborhood Hits	100
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_HUMAN
θ value	θ > 10 (rank : 1510)	NC score	0.061745 (rank : 1382)
Query Neighborhood Hits	1103	Target Neighborhood Hits	437	Shared Neighborhood Hits	66
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA12_MOUSE
θ value	θ > 10 (rank : 1511)	NC score	0.054567 (rank : 1510)
Query Neighborhood Hits	1103	Target Neighborhood Hits	399	Shared Neighborhood Hits	57
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCAM2_HUMAN
θ value	θ > 10 (rank : 1512)	NC score	0.070460 (rank : 1286)
Query Neighborhood Hits	1103	Target Neighborhood Hits	441	Shared Neighborhood Hits	76
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCAM2_MOUSE
θ value	θ > 10 (rank : 1513)	NC score	0.073548 (rank : 1260)
Query Neighborhood Hits	1103	Target Neighborhood Hits	472	Shared Neighborhood Hits	78
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCF1_HUMAN
θ value	θ > 10 (rank : 1514)	NC score	0.063054 (rank : 1363)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 1515)	NC score	0.062993 (rank : 1365)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 1516)	NC score	0.055955 (rank : 1487)
Query Neighborhood Hits	1103	Target Neighborhood Hits	229	Shared Neighborhood Hits	39
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK1_HUMAN
θ value	θ > 10 (rank : 1517)	NC score	0.185478 (rank : 1102)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	62
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1518)	NC score	0.184671 (rank : 1104)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	66
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 1519)	NC score	0.068770 (rank : 1300)
Query Neighborhood Hits	1103	Target Neighborhood Hits	457	Shared Neighborhood Hits	117
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEK3_HUMAN
θ value	θ > 10 (rank : 1520)	NC score	0.527494 (rank : 301)
Query Neighborhood Hits	1103	Target Neighborhood Hits	865	Shared Neighborhood Hits	571
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 1521)	NC score	0.523355 (rank : 312)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	565
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEO1_HUMAN
θ value	θ > 10 (rank : 1522)	NC score	0.092965 (rank : 1192)
Query Neighborhood Hits	1103	Target Neighborhood Hits	530	Shared Neighborhood Hits	93
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 1523)	NC score	0.092053 (rank : 1196)
Query Neighborhood Hits	1103	Target Neighborhood Hits	523	Shared Neighborhood Hits	92
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NFASC_HUMAN
θ value	θ > 10 (rank : 1524)	NC score	0.073803 (rank : 1257)
Query Neighborhood Hits	1103	Target Neighborhood Hits	497	Shared Neighborhood Hits	94
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	θ > 10 (rank : 1525)	NC score	0.066012 (rank : 1328)
Query Neighborhood Hits	1103	Target Neighborhood Hits	475	Shared Neighborhood Hits	92
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NIN_HUMAN
θ value	θ > 10 (rank : 1526)	NC score	0.058433 (rank : 1436)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1416	Shared Neighborhood Hits	193
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NIN_MOUSE
θ value	θ > 10 (rank : 1527)	NC score	0.056118 (rank : 1484)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1376	Shared Neighborhood Hits	202
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

NOP14_HUMAN
θ value	θ > 10 (rank : 1528)	NC score	0.072851 (rank : 1266)
Query Neighborhood Hits	1103	Target Neighborhood Hits	573	Shared Neighborhood Hits	150
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

NPHP1_HUMAN
θ value	θ > 10 (rank : 1529)	NC score	0.101392 (rank : 1173)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	72
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1530)	NC score	0.104637 (rank : 1168)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRBP_HUMAN
θ value	θ > 10 (rank : 1531)	NC score	0.377333 (rank : 914)
Query Neighborhood Hits	1103	Target Neighborhood Hits	448	Shared Neighborhood Hits	328
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	θ > 10 (rank : 1532)	NC score	0.376165 (rank : 915)
Query Neighborhood Hits	1103	Target Neighborhood Hits	442	Shared Neighborhood Hits	319
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

NRCAM_HUMAN
θ value	θ > 10 (rank : 1533)	NC score	0.075635 (rank : 1249)
Query Neighborhood Hits	1103	Target Neighborhood Hits	439	Shared Neighborhood Hits	86
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	θ > 10 (rank : 1534)	NC score	0.072858 (rank : 1265)
Query Neighborhood Hits	1103	Target Neighborhood Hits	432	Shared Neighborhood Hits	86
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NUD12_HUMAN
θ value	θ > 10 (rank : 1535)	NC score	0.247495 (rank : 1055)
Query Neighborhood Hits	1103	Target Neighborhood Hits	222	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

NUD12_MOUSE
θ value	θ > 10 (rank : 1536)	NC score	0.263677 (rank : 1042)
Query Neighborhood Hits	1103	Target Neighborhood Hits	243	Shared Neighborhood Hits	198
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

OPTN_MOUSE
θ value	θ > 10 (rank : 1537)	NC score	0.056655 (rank : 1472)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1120	Shared Neighborhood Hits	184
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

P55G_HUMAN
θ value	θ > 10 (rank : 1538)	NC score	0.125995 (rank : 1138)
Query Neighborhood Hits	1103	Target Neighborhood Hits	451	Shared Neighborhood Hits	119
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1539)	NC score	0.118667 (rank : 1150)
Query Neighborhood Hits	1103	Target Neighborhood Hits	401	Shared Neighborhood Hits	107
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1540)	NC score	0.100670 (rank : 1174)
Query Neighborhood Hits	1103	Target Neighborhood Hits	479	Shared Neighborhood Hits	95
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1541)	NC score	0.100306 (rank : 1175)
Query Neighborhood Hits	1103	Target Neighborhood Hits	435	Shared Neighborhood Hits	87
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1542)	NC score	0.119400 (rank : 1147)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	129
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1543)	NC score	0.124846 (rank : 1139)
Query Neighborhood Hits	1103	Target Neighborhood Hits	519	Shared Neighborhood Hits	126
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 1544)	NC score	0.069425 (rank : 1295)
Query Neighborhood Hits	1103	Target Neighborhood Hits	320	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 1545)	NC score	0.067056 (rank : 1316)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	58
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 1546)	NC score	0.072084 (rank : 1271)
Query Neighborhood Hits	1103	Target Neighborhood Hits	339	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 1547)	NC score	0.072829 (rank : 1267)
Query Neighborhood Hits	1103	Target Neighborhood Hits	382	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 1548)	NC score	0.071752 (rank : 1278)
Query Neighborhood Hits	1103	Target Neighborhood Hits	385	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 1549)	NC score	0.068152 (rank : 1306)
Query Neighborhood Hits	1103	Target Neighborhood Hits	380	Shared Neighborhood Hits	99
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PASK_HUMAN
θ value	θ > 10 (rank : 1550)	NC score	0.465991 (rank : 601)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	548
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PCTK1_HUMAN
θ value	θ > 10 (rank : 1551)	NC score	0.467777 (rank : 594)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 1552)	NC score	0.468116 (rank : 591)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	556
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 1553)	NC score	0.470015 (rank : 587)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	556
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 1554)	NC score	0.470109 (rank : 585)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	556
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 1555)	NC score	0.465035 (rank : 605)
Query Neighborhood Hits	1103	Target Neighborhood Hits	827	Shared Neighborhood Hits	553
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 1556)	NC score	0.468627 (rank : 588)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	555
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PEPL_HUMAN
θ value	θ > 10 (rank : 1557)	NC score	0.051040 (rank : 1580)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1141	Shared Neighborhood Hits	180
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PEPL_MOUSE
θ value	θ > 10 (rank : 1558)	NC score	0.050481 (rank : 1589)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1105	Shared Neighborhood Hits	177
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PGFRL_HUMAN
θ value	θ > 10 (rank : 1559)	NC score	0.061409 (rank : 1389)
Query Neighborhood Hits	1103	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PGFRL_MOUSE
θ value	θ > 10 (rank : 1560)	NC score	0.063372 (rank : 1357)
Query Neighborhood Hits	1103	Target Neighborhood Hits	106	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PHKG1_MOUSE
θ value	θ > 10 (rank : 1561)	NC score	0.446175 (rank : 692)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	561
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PI3R4_HUMAN
θ value	θ > 10 (rank : 1562)	NC score	0.116774 (rank : 1155)
Query Neighborhood Hits	1103	Target Neighborhood Hits	534	Shared Neighborhood Hits	231
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	θ > 10 (rank : 1563)	NC score	0.121884 (rank : 1141)
Query Neighborhood Hits	1103	Target Neighborhood Hits	535	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PIM1_HUMAN
θ value	θ > 10 (rank : 1564)	NC score	0.434058 (rank : 715)
Query Neighborhood Hits	1103	Target Neighborhood Hits	797	Shared Neighborhood Hits	533
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	θ > 10 (rank : 1565)	NC score	0.431334 (rank : 720)
Query Neighborhood Hits	1103	Target Neighborhood Hits	787	Shared Neighborhood Hits	525
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_HUMAN
θ value	θ > 10 (rank : 1566)	NC score	0.448094 (rank : 687)
Query Neighborhood Hits	1103	Target Neighborhood Hits	808	Shared Neighborhood Hits	547
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PIM2_MOUSE
θ value	θ > 10 (rank : 1567)	NC score	0.441057 (rank : 702)
Query Neighborhood Hits	1103	Target Neighborhood Hits	809	Shared Neighborhood Hits	544
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM3_HUMAN
θ value	θ > 10 (rank : 1568)	NC score	0.428268 (rank : 729)
Query Neighborhood Hits	1103	Target Neighborhood Hits	789	Shared Neighborhood Hits	529
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	θ > 10 (rank : 1569)	NC score	0.422047 (rank : 744)
Query Neighborhood Hits	1103	Target Neighborhood Hits	783	Shared Neighborhood Hits	525
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PININ_MOUSE
θ value	θ > 10 (rank : 1570)	NC score	0.065470 (rank : 1338)
Query Neighborhood Hits	1103	Target Neighborhood Hits	777	Shared Neighborhood Hits	170
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PINK1_HUMAN
θ value	θ > 10 (rank : 1571)	NC score	0.411236 (rank : 790)
Query Neighborhood Hits	1103	Target Neighborhood Hits	741	Shared Neighborhood Hits	500
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 1572)	NC score	0.439699 (rank : 704)
Query Neighborhood Hits	1103	Target Neighborhood Hits	726	Shared Neighborhood Hits	515
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 1573)	NC score	0.487978 (rank : 475)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	570
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 1574)	NC score	0.487351 (rank : 480)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	566
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 1575)	NC score	0.484080 (rank : 493)
Query Neighborhood Hits	1103	Target Neighborhood Hits	892	Shared Neighborhood Hits	571
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 1576)	NC score	0.483562 (rank : 497)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	567
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 1577)	NC score	0.472968 (rank : 569)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	567
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 1578)	NC score	0.479678 (rank : 532)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	585
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLCG1_HUMAN
θ value	θ > 10 (rank : 1579)	NC score	0.120139 (rank : 1146)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	64
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 1580)	NC score	0.121472 (rank : 1143)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	67
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 1581)	NC score	0.120998 (rank : 1145)
Query Neighborhood Hits	1103	Target Neighborhood Hits	280	Shared Neighborhood Hits	57
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PMYT1_HUMAN
θ value	θ > 10 (rank : 1582)	NC score	0.437216 (rank : 713)
Query Neighborhood Hits	1103	Target Neighborhood Hits	814	Shared Neighborhood Hits	552
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	θ > 10 (rank : 1583)	NC score	0.451651 (rank : 674)
Query Neighborhood Hits	1103	Target Neighborhood Hits	910	Shared Neighborhood Hits	566
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PPIP1_HUMAN
θ value	θ > 10 (rank : 1584)	NC score	0.077222 (rank : 1239)
Query Neighborhood Hits	1103	Target Neighborhood Hits	389	Shared Neighborhood Hits	96
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 1585)	NC score	0.074786 (rank : 1253)
Query Neighborhood Hits	1103	Target Neighborhood Hits	377	Shared Neighborhood Hits	94
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRP4B_HUMAN
θ value	θ > 10 (rank : 1586)	NC score	0.413032 (rank : 778)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1030	Shared Neighborhood Hits	586
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 1587)	NC score	0.412358 (rank : 783)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1040	Shared Neighborhood Hits	589
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PRPK_HUMAN
θ value	θ > 10 (rank : 1588)	NC score	0.086982 (rank : 1212)
Query Neighborhood Hits	1103	Target Neighborhood Hits	131	Shared Neighborhood Hits	101
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1589)	NC score	0.092236 (rank : 1195)
Query Neighborhood Hits	1103	Target Neighborhood Hits	139	Shared Neighborhood Hits	100
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PTN11_HUMAN
θ value	θ > 10 (rank : 1590)	NC score	0.075380 (rank : 1251)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 1591)	NC score	0.075532 (rank : 1250)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 1592)	NC score	0.056165 (rank : 1483)
Query Neighborhood Hits	1103	Target Neighborhood Hits	234	Shared Neighborhood Hits	46
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 1593)	NC score	0.059402 (rank : 1418)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTPRD_HUMAN
θ value	θ > 10 (rank : 1594)	NC score	0.071564 (rank : 1280)
Query Neighborhood Hits	1103	Target Neighborhood Hits	485	Shared Neighborhood Hits	85
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 1595)	NC score	0.071231 (rank : 1283)
Query Neighborhood Hits	1103	Target Neighborhood Hits	491	Shared Neighborhood Hits	83
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
θ value	θ > 10 (rank : 1596)	NC score	0.070271 (rank : 1289)
Query Neighborhood Hits	1103	Target Neighborhood Hits	489	Shared Neighborhood Hits	85
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRS_HUMAN
θ value	θ > 10 (rank : 1597)	NC score	0.070302 (rank : 1288)
Query Neighborhood Hits	1103	Target Neighborhood Hits	472	Shared Neighborhood Hits	85
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PUNC_HUMAN
θ value	θ > 10 (rank : 1598)	NC score	0.060805 (rank : 1397)
Query Neighborhood Hits	1103	Target Neighborhood Hits	449	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
θ value	θ > 10 (rank : 1599)	NC score	0.057337 (rank : 1455)
Query Neighborhood Hits	1103	Target Neighborhood Hits	501	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PXK_HUMAN
θ value	θ > 10 (rank : 1600)	NC score	0.059485 (rank : 1415)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	108
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 1601)	NC score	0.093714 (rank : 1188)
Query Neighborhood Hits	1103	Target Neighborhood Hits	320	Shared Neighborhood Hits	165
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RABE1_HUMAN
θ value	θ > 10 (rank : 1602)	NC score	0.056053 (rank : 1485)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1104	Shared Neighborhood Hits	186
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	θ > 10 (rank : 1603)	NC score	0.054122 (rank : 1521)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1105	Shared Neighborhood Hits	183
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RAD50_HUMAN
θ value	θ > 10 (rank : 1604)	NC score	0.053979 (rank : 1524)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1317	Shared Neighborhood Hits	202
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	θ > 10 (rank : 1605)	NC score	0.054661 (rank : 1509)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1366	Shared Neighborhood Hits	200
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RASA1_HUMAN
θ value	θ > 10 (rank : 1606)	NC score	0.139926 (rank : 1125)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RB6I2_MOUSE
θ value	θ > 10 (rank : 1607)	NC score	0.060533 (rank : 1402)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1433	Shared Neighborhood Hits	206
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBBP6_HUMAN
θ value	θ > 10 (rank : 1608)	NC score	0.062099 (rank : 1379)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1135	Shared Neighborhood Hits	207
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RBBP6_MOUSE
θ value	θ > 10 (rank : 1609)	NC score	0.068197 (rank : 1304)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1014	Shared Neighborhood Hits	191
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RBP24_HUMAN
θ value	θ > 10 (rank : 1610)	NC score	0.057326 (rank : 1456)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1559	Shared Neighborhood Hits	207
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

REN3B_HUMAN
θ value	θ > 10 (rank : 1611)	NC score	0.067240 (rank : 1314)
Query Neighborhood Hits	1103	Target Neighborhood Hits	412	Shared Neighborhood Hits	101
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

RIMB1_HUMAN
θ value	θ > 10 (rank : 1612)	NC score	0.065512 (rank : 1336)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1479	Shared Neighborhood Hits	219
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 1613)	NC score	0.067688 (rank : 1311)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1376	Shared Neighborhood Hits	233
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIPK3_MOUSE
θ value	θ > 10 (rank : 1614)	NC score	0.571277 (rank : 226)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	568
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RK_HUMAN
θ value	θ > 10 (rank : 1615)	NC score	0.442192 (rank : 700)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	551
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 1616)	NC score	0.444000 (rank : 696)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	549
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROBO1_HUMAN
θ value	θ > 10 (rank : 1617)	NC score	0.072137 (rank : 1270)
Query Neighborhood Hits	1103	Target Neighborhood Hits	529	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
θ value	θ > 10 (rank : 1618)	NC score	0.071620 (rank : 1279)
Query Neighborhood Hits	1103	Target Neighborhood Hits	559	Shared Neighborhood Hits	88
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO2_HUMAN
θ value	θ > 10 (rank : 1619)	NC score	0.071867 (rank : 1276)
Query Neighborhood Hits	1103	Target Neighborhood Hits	479	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
θ value	θ > 10 (rank : 1620)	NC score	0.071918 (rank : 1274)
Query Neighborhood Hits	1103	Target Neighborhood Hits	504	Shared Neighborhood Hits	82
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
θ value	θ > 10 (rank : 1621)	NC score	0.068425 (rank : 1302)
Query Neighborhood Hits	1103	Target Neighborhood Hits	570	Shared Neighborhood Hits	92
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ROBO3_MOUSE
θ value	θ > 10 (rank : 1622)	NC score	0.066296 (rank : 1325)
Query Neighborhood Hits	1103	Target Neighborhood Hits	524	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

ROCK2_HUMAN
θ value	θ > 10 (rank : 1623)	NC score	0.409303 (rank : 798)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2073	Shared Neighborhood Hits	716
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ROCK2_MOUSE
θ value	θ > 10 (rank : 1624)	NC score	0.403982 (rank : 819)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2072	Shared Neighborhood Hits	714
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

RPKL1_HUMAN
θ value	θ > 10 (rank : 1625)	NC score	0.318676 (rank : 1001)
Query Neighborhood Hits	1103	Target Neighborhood Hits	708	Shared Neighborhood Hits	459
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 1626)	NC score	0.317271 (rank : 1002)
Query Neighborhood Hits	1103	Target Neighborhood Hits	704	Shared Neighborhood Hits	462
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RRBP1_HUMAN
θ value	θ > 10 (rank : 1627)	NC score	0.057212 (rank : 1459)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1306	Shared Neighborhood Hits	207
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RSNL2_HUMAN
θ value	θ > 10 (rank : 1628)	NC score	0.112094 (rank : 1163)
Query Neighborhood Hits	1103	Target Neighborhood Hits	136	Shared Neighborhood Hits	110
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

RSNL2_MOUSE
θ value	θ > 10 (rank : 1629)	NC score	0.096271 (rank : 1183)
Query Neighborhood Hits	1103	Target Neighborhood Hits	129	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

RUFY2_HUMAN
θ value	θ > 10 (rank : 1630)	NC score	0.050124 (rank : 1593)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1208	Shared Neighborhood Hits	176
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SASH1_MOUSE
θ value	θ > 10 (rank : 1631)	NC score	0.051280 (rank : 1573)
Query Neighborhood Hits	1103	Target Neighborhood Hits	263	Shared Neighborhood Hits	70
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SDCG8_HUMAN
θ value	θ > 10 (rank : 1632)	NC score	0.056024 (rank : 1486)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1002	Shared Neighborhood Hits	180
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SDCG8_MOUSE
θ value	θ > 10 (rank : 1633)	NC score	0.053643 (rank : 1533)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	174
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SDK1_HUMAN
θ value	θ > 10 (rank : 1634)	NC score	0.083538 (rank : 1218)
Query Neighborhood Hits	1103	Target Neighborhood Hits	511	Shared Neighborhood Hits	88
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	θ > 10 (rank : 1635)	NC score	0.081677 (rank : 1221)
Query Neighborhood Hits	1103	Target Neighborhood Hits	495	Shared Neighborhood Hits	87
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	θ > 10 (rank : 1636)	NC score	0.081393 (rank : 1224)
Query Neighborhood Hits	1103	Target Neighborhood Hits	495	Shared Neighborhood Hits	92
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	θ > 10 (rank : 1637)	NC score	0.078792 (rank : 1235)
Query Neighborhood Hits	1103	Target Neighborhood Hits	480	Shared Neighborhood Hits	87
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SFR12_HUMAN
θ value	θ > 10 (rank : 1638)	NC score	0.059808 (rank : 1407)
Query Neighborhood Hits	1103	Target Neighborhood Hits	553	Shared Neighborhood Hits	109
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

SGK1_HUMAN
θ value	θ > 10 (rank : 1639)	NC score	0.466497 (rank : 598)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	563
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
θ value	θ > 10 (rank : 1640)	NC score	0.465712 (rank : 603)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	564
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK3_HUMAN
θ value	θ > 10 (rank : 1641)	NC score	0.452853 (rank : 671)
Query Neighborhood Hits	1103	Target Neighborhood Hits	877	Shared Neighborhood Hits	558
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
θ value	θ > 10 (rank : 1642)	NC score	0.453850 (rank : 668)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	559
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SH21A_HUMAN
θ value	θ > 10 (rank : 1643)	NC score	0.154556 (rank : 1121)
Query Neighborhood Hits	1103	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1644)	NC score	0.164507 (rank : 1115)
Query Neighborhood Hits	1103	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1645)	NC score	0.162465 (rank : 1116)
Query Neighborhood Hits	1103	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1646)	NC score	0.180367 (rank : 1106)
Query Neighborhood Hits	1103	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 1647)	NC score	0.054148 (rank : 1519)
Query Neighborhood Hits	1103	Target Neighborhood Hits	144	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 1648)	NC score	0.063329 (rank : 1358)
Query Neighborhood Hits	1103	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 1649)	NC score	0.051338 (rank : 1572)
Query Neighborhood Hits	1103	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 1650)	NC score	0.114089 (rank : 1162)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	139
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 1651)	NC score	0.090132 (rank : 1204)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	111
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 1652)	NC score	0.065794 (rank : 1331)
Query Neighborhood Hits	1103	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 1653)	NC score	0.069988 (rank : 1290)
Query Neighborhood Hits	1103	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G2_HUMAN
θ value	θ > 10 (rank : 1654)	NC score	0.053978 (rank : 1525)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	67
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
θ value	θ > 10 (rank : 1655)	NC score	0.050805 (rank : 1585)
Query Neighborhood Hits	1103	Target Neighborhood Hits	236	Shared Neighborhood Hits	45
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 1656)	NC score	0.057512 (rank : 1449)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	73
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 1657)	NC score	0.057438 (rank : 1453)
Query Neighborhood Hits	1103	Target Neighborhood Hits	332	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 1658)	NC score	0.076644 (rank : 1244)
Query Neighborhood Hits	1103	Target Neighborhood Hits	446	Shared Neighborhood Hits	87
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 1659)	NC score	0.092465 (rank : 1194)
Query Neighborhood Hits	1103	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 1660)	NC score	0.097235 (rank : 1180)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 1661)	NC score	0.098050 (rank : 1178)
Query Neighborhood Hits	1103	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 1662)	NC score	0.097436 (rank : 1179)
Query Neighborhood Hits	1103	Target Neighborhood Hits	180	Shared Neighborhood Hits	47
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 1663)	NC score	0.098401 (rank : 1177)
Query Neighborhood Hits	1103	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 1664)	NC score	0.090937 (rank : 1199)
Query Neighborhood Hits	1103	Target Neighborhood Hits	144	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 1665)	NC score	0.083759 (rank : 1217)
Query Neighborhood Hits	1103	Target Neighborhood Hits	155	Shared Neighborhood Hits	40
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 1666)	NC score	0.090875 (rank : 1202)
Query Neighborhood Hits	1103	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 1667)	NC score	0.090929 (rank : 1200)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 1668)	NC score	0.093300 (rank : 1189)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 1669)	NC score	0.117598 (rank : 1154)
Query Neighborhood Hits	1103	Target Neighborhood Hits	164	Shared Neighborhood Hits	51
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 1670)	NC score	0.119112 (rank : 1149)
Query Neighborhood Hits	1103	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 1671)	NC score	0.247366 (rank : 1056)
Query Neighborhood Hits	1103	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1672)	NC score	0.244032 (rank : 1058)
Query Neighborhood Hits	1103	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1673)	NC score	0.248641 (rank : 1054)
Query Neighborhood Hits	1103	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1674)	NC score	0.256516 (rank : 1049)
Query Neighborhood Hits	1103	Target Neighborhood Hits	136	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SM1L2_HUMAN
θ value	θ > 10 (rank : 1675)	NC score	0.051628 (rank : 1567)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1019	Shared Neighborhood Hits	172
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SMC1A_HUMAN
θ value	θ > 10 (rank : 1676)	NC score	0.053753 (rank : 1528)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1346	Shared Neighborhood Hits	210
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	θ > 10 (rank : 1677)	NC score	0.057445 (rank : 1452)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1384	Shared Neighborhood Hits	218
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SMC2_HUMAN
θ value	θ > 10 (rank : 1678)	NC score	0.057722 (rank : 1443)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1405	Shared Neighborhood Hits	223
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SN1L2_MOUSE
θ value	θ > 10 (rank : 1679)	NC score	0.503322 (rank : 415)
Query Neighborhood Hits	1103	Target Neighborhood Hits	944	Shared Neighborhood Hits	574
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 1680)	NC score	0.476358 (rank : 547)
Query Neighborhood Hits	1103	Target Neighborhood Hits	855	Shared Neighborhood Hits	558
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	θ > 10 (rank : 1681)	NC score	0.478175 (rank : 540)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	552
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SOCS6_HUMAN
θ value	θ > 10 (rank : 1682)	NC score	0.053608 (rank : 1535)
Query Neighborhood Hits	1103	Target Neighborhood Hits	126	Shared Neighborhood Hits	35
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 1683)	NC score	0.054267 (rank : 1514)
Query Neighborhood Hits	1103	Target Neighborhood Hits	146	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 1684)	NC score	0.076825 (rank : 1241)
Query Neighborhood Hits	1103	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPEG_HUMAN
θ value	θ > 10 (rank : 1685)	NC score	0.429028 (rank : 727)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1762	Shared Neighborhood Hits	614
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
θ value	θ > 10 (rank : 1686)	NC score	0.426905 (rank : 734)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1959	Shared Neighborhood Hits	646
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 1687)	NC score	0.095181 (rank : 1185)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 1688)	NC score	0.089293 (rank : 1205)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA1_HUMAN
θ value	θ > 10 (rank : 1689)	NC score	0.057449 (rank : 1451)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	130
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 1690)	NC score	0.063923 (rank : 1351)
Query Neighborhood Hits	1103	Target Neighborhood Hits	675	Shared Neighborhood Hits	131
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 1691)	NC score	0.068366 (rank : 1303)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	143
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_MOUSE
θ value	θ > 10 (rank : 1692)	NC score	0.059080 (rank : 1425)
Query Neighborhood Hits	1103	Target Neighborhood Hits	409	Shared Neighborhood Hits	82
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 1693)	NC score	0.058984 (rank : 1429)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	57
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 1694)	NC score	0.056929 (rank : 1466)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	59
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRPK1_HUMAN
θ value	θ > 10 (rank : 1695)	NC score	0.211971 (rank : 1073)
Query Neighborhood Hits	1103	Target Neighborhood Hits	706	Shared Neighborhood Hits	396
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	θ > 10 (rank : 1696)	NC score	0.209945 (rank : 1076)
Query Neighborhood Hits	1103	Target Neighborhood Hits	639	Shared Neighborhood Hits	377
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRRM2_MOUSE
θ value	θ > 10 (rank : 1697)	NC score	0.058554 (rank : 1434)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1470	Shared Neighborhood Hits	188
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ST17A_HUMAN
θ value	θ > 10 (rank : 1698)	NC score	0.481212 (rank : 517)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	556
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST32A_HUMAN
θ value	θ > 10 (rank : 1699)	NC score	0.474431 (rank : 559)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	557
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32B_HUMAN
θ value	θ > 10 (rank : 1700)	NC score	0.461976 (rank : 616)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	555
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 1701)	NC score	0.463830 (rank : 607)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	553
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_MOUSE
θ value	θ > 10 (rank : 1702)	NC score	0.456843 (rank : 646)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	552
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST38L_HUMAN
θ value	θ > 10 (rank : 1703)	NC score	0.401820 (rank : 827)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	547
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 1704)	NC score	0.391153 (rank : 878)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	546
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STAC3_HUMAN
θ value	θ > 10 (rank : 1705)	NC score	0.115771 (rank : 1158)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1706)	NC score	0.114588 (rank : 1160)
Query Neighborhood Hits	1103	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1707)	NC score	0.102188 (rank : 1170)
Query Neighborhood Hits	1103	Target Neighborhood Hits	276	Shared Neighborhood Hits	81
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1708)	NC score	0.111589 (rank : 1164)
Query Neighborhood Hits	1103	Target Neighborhood Hits	268	Shared Neighborhood Hits	80
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 1709)	NC score	0.079731 (rank : 1232)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 1710)	NC score	0.081119 (rank : 1226)
Query Neighborhood Hits	1103	Target Neighborhood Hits	273	Shared Neighborhood Hits	56
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 1711)	NC score	0.079246 (rank : 1234)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	61
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 1712)	NC score	0.083869 (rank : 1216)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	64
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STK23_HUMAN
θ value	θ > 10 (rank : 1713)	NC score	0.206419 (rank : 1079)
Query Neighborhood Hits	1103	Target Neighborhood Hits	556	Shared Neighborhood Hits	352
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	θ > 10 (rank : 1714)	NC score	0.208362 (rank : 1077)
Query Neighborhood Hits	1103	Target Neighborhood Hits	572	Shared Neighborhood Hits	358
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK31_HUMAN
θ value	θ > 10 (rank : 1715)	NC score	0.230492 (rank : 1061)
Query Neighborhood Hits	1103	Target Neighborhood Hits	570	Shared Neighborhood Hits	319
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

STK31_MOUSE
θ value	θ > 10 (rank : 1716)	NC score	0.195992 (rank : 1088)
Query Neighborhood Hits	1103	Target Neighborhood Hits	474	Shared Neighborhood Hits	268
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 1717)	NC score	0.498425 (rank : 433)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	553
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK38_HUMAN
θ value	θ > 10 (rank : 1718)	NC score	0.406221 (rank : 811)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	551
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 1719)	NC score	0.406679 (rank : 810)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	551
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK40_HUMAN
θ value	θ > 10 (rank : 1720)	NC score	0.379174 (rank : 909)
Query Neighborhood Hits	1103	Target Neighborhood Hits	751	Shared Neighborhood Hits	496
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 1721)	NC score	0.379316 (rank : 908)
Query Neighborhood Hits	1103	Target Neighborhood Hits	751	Shared Neighborhood Hits	496
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

SWP70_MOUSE
θ value	θ > 10 (rank : 1722)	NC score	0.054251 (rank : 1515)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1097	Shared Neighborhood Hits	175
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_HUMAN
θ value	θ > 10 (rank : 1723)	NC score	0.061107 (rank : 1392)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1313	Shared Neighborhood Hits	215
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYCP1_MOUSE
θ value	θ > 10 (rank : 1724)	NC score	0.057963 (rank : 1440)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1456	Shared Neighborhood Hits	217
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TACC2_HUMAN
θ value	θ > 10 (rank : 1725)	NC score	0.054343 (rank : 1513)
Query Neighborhood Hits	1103	Target Neighborhood Hits	856	Shared Neighborhood Hits	165
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TACC2_MOUSE
θ value	θ > 10 (rank : 1726)	NC score	0.050086 (rank : 1594)
Query Neighborhood Hits	1103	Target Neighborhood Hits	774	Shared Neighborhood Hits	150
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TARA_HUMAN
θ value	θ > 10 (rank : 1727)	NC score	0.055341 (rank : 1499)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1626	Shared Neighborhood Hits	245
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARSH_HUMAN
θ value	θ > 10 (rank : 1728)	NC score	0.059703 (rank : 1408)
Query Neighborhood Hits	1103	Target Neighborhood Hits	768	Shared Neighborhood Hits	113
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TAXB1_HUMAN
θ value	θ > 10 (rank : 1729)	NC score	0.055461 (rank : 1495)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	146
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TCAL5_HUMAN
θ value	θ > 10 (rank : 1730)	NC score	0.051892 (rank : 1563)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	182
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TCRG1_HUMAN
θ value	θ > 10 (rank : 1731)	NC score	0.054558 (rank : 1511)
Query Neighborhood Hits	1103	Target Neighborhood Hits	929	Shared Neighborhood Hits	186
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 1732)	NC score	0.055060 (rank : 1505)
Query Neighborhood Hits	1103	Target Neighborhood Hits	947	Shared Neighborhood Hits	185
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TENS4_MOUSE
θ value	θ > 10 (rank : 1733)	NC score	0.055725 (rank : 1493)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TGFR2_HUMAN
θ value	θ > 10 (rank : 1734)	NC score	0.482311 (rank : 504)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	538
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 1735)	NC score	0.481605 (rank : 512)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	539
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGON2_HUMAN
θ value	θ > 10 (rank : 1736)	NC score	0.062396 (rank : 1370)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1037	Shared Neighborhood Hits	197
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TLK1_HUMAN
θ value	θ > 10 (rank : 1737)	NC score	0.459116 (rank : 631)
Query Neighborhood Hits	1103	Target Neighborhood Hits	967	Shared Neighborhood Hits	549
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 1738)	NC score	0.458379 (rank : 636)
Query Neighborhood Hits	1103	Target Neighborhood Hits	947	Shared Neighborhood Hits	543
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 1739)	NC score	0.467018 (rank : 597)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1044	Shared Neighborhood Hits	571
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 1740)	NC score	0.467944 (rank : 592)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1088	Shared Neighborhood Hits	590
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TOPK_HUMAN
θ value	θ > 10 (rank : 1741)	NC score	0.564898 (rank : 229)
Query Neighborhood Hits	1103	Target Neighborhood Hits	605	Shared Neighborhood Hits	453
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1742)	NC score	0.561606 (rank : 237)
Query Neighborhood Hits	1103	Target Neighborhood Hits	618	Shared Neighborhood Hits	464
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRDN_HUMAN
θ value	θ > 10 (rank : 1743)	NC score	0.059987 (rank : 1405)
Query Neighborhood Hits	1103	Target Neighborhood Hits	542	Shared Neighborhood Hits	112
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

TRIB1_HUMAN
θ value	θ > 10 (rank : 1744)	NC score	0.299701 (rank : 1015)
Query Neighborhood Hits	1103	Target Neighborhood Hits	598	Shared Neighborhood Hits	393
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 1745)	NC score	0.301169 (rank : 1013)
Query Neighborhood Hits	1103	Target Neighborhood Hits	593	Shared Neighborhood Hits	397
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 1746)	NC score	0.344829 (rank : 966)
Query Neighborhood Hits	1103	Target Neighborhood Hits	657	Shared Neighborhood Hits	463
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 1747)	NC score	0.343277 (rank : 967)
Query Neighborhood Hits	1103	Target Neighborhood Hits	653	Shared Neighborhood Hits	460
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 1748)	NC score	0.277776 (rank : 1033)
Query Neighborhood Hits	1103	Target Neighborhood Hits	519	Shared Neighborhood Hits	335
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 1749)	NC score	0.294697 (rank : 1019)
Query Neighborhood Hits	1103	Target Neighborhood Hits	578	Shared Neighborhood Hits	385
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIPB_HUMAN
θ value	θ > 10 (rank : 1750)	NC score	0.062566 (rank : 1368)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1587	Shared Neighborhood Hits	218
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TRPV1_HUMAN
θ value	θ > 10 (rank : 1751)	NC score	0.088400 (rank : 1209)
Query Neighborhood Hits	1103	Target Neighborhood Hits	184	Shared Neighborhood Hits	133
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	θ > 10 (rank : 1752)	NC score	0.095313 (rank : 1184)
Query Neighborhood Hits	1103	Target Neighborhood Hits	189	Shared Neighborhood Hits	137
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV2_HUMAN
θ value	θ > 10 (rank : 1753)	NC score	0.080389 (rank : 1230)
Query Neighborhood Hits	1103	Target Neighborhood Hits	130	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 1754)	NC score	0.056472 (rank : 1476)
Query Neighborhood Hits	1103	Target Neighborhood Hits	111	Shared Neighborhood Hits	82
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV3_HUMAN
θ value	θ > 10 (rank : 1755)	NC score	0.091531 (rank : 1198)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	126
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV3_MOUSE
θ value	θ > 10 (rank : 1756)	NC score	0.093165 (rank : 1190)
Query Neighborhood Hits	1103	Target Neighborhood Hits	188	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV5_HUMAN
θ value	θ > 10 (rank : 1757)	NC score	0.201057 (rank : 1081)
Query Neighborhood Hits	1103	Target Neighborhood Hits	261	Shared Neighborhood Hits	199
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV5_MOUSE
θ value	θ > 10 (rank : 1758)	NC score	0.215078 (rank : 1069)
Query Neighborhood Hits	1103	Target Neighborhood Hits	278	Shared Neighborhood Hits	218
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV6_HUMAN
θ value	θ > 10 (rank : 1759)	NC score	0.199125 (rank : 1086)
Query Neighborhood Hits	1103	Target Neighborhood Hits	262	Shared Neighborhood Hits	195
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TSSK1_HUMAN
θ value	θ > 10 (rank : 1760)	NC score	0.475357 (rank : 550)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	552
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 1761)	NC score	0.492883 (rank : 450)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	559
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 1762)	NC score	0.490206 (rank : 460)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	558
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 1763)	NC score	0.479603 (rank : 533)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	550
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK3_HUMAN
θ value	θ > 10 (rank : 1764)	NC score	0.456617 (rank : 649)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	536
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
θ value	θ > 10 (rank : 1765)	NC score	0.456256 (rank : 651)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	537
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK4_HUMAN
θ value	θ > 10 (rank : 1766)	NC score	0.497495 (rank : 435)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	561
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 1767)	NC score	0.504350 (rank : 410)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	561
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TTBK1_HUMAN
θ value	θ > 10 (rank : 1768)	NC score	0.398299 (rank : 841)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1058	Shared Neighborhood Hits	510
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 1769)	NC score	0.383697 (rank : 902)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	490
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 1770)	NC score	0.383028 (rank : 904)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	481
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTK_HUMAN
θ value	θ > 10 (rank : 1771)	NC score	0.449320 (rank : 680)
Query Neighborhood Hits	1103	Target Neighborhood Hits	816	Shared Neighborhood Hits	516
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 1772)	NC score	0.437868 (rank : 712)
Query Neighborhood Hits	1103	Target Neighborhood Hits	803	Shared Neighborhood Hits	496
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TXND2_MOUSE
θ value	θ > 10 (rank : 1773)	NC score	0.072017 (rank : 1273)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	206
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

UHMK1_HUMAN
θ value	θ > 10 (rank : 1774)	NC score	0.445461 (rank : 693)
Query Neighborhood Hits	1103	Target Neighborhood Hits	808	Shared Neighborhood Hits	516
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 1775)	NC score	0.446501 (rank : 691)
Query Neighborhood Hits	1103	Target Neighborhood Hits	809	Shared Neighborhood Hits	516
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK4_MOUSE
θ value	θ > 10 (rank : 1776)	NC score	0.453040 (rank : 670)
Query Neighborhood Hits	1103	Target Neighborhood Hits	793	Shared Neighborhood Hits	542
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

USH2A_HUMAN
θ value	θ > 10 (rank : 1777)	NC score	0.050157 (rank : 1592)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	68
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	θ > 10 (rank : 1778)	NC score	0.051240 (rank : 1575)
Query Neighborhood Hits	1103	Target Neighborhood Hits	626	Shared Neighborhood Hits	72
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VAV2_HUMAN
θ value	θ > 10 (rank : 1779)	NC score	0.119323 (rank : 1148)
Query Neighborhood Hits	1103	Target Neighborhood Hits	453	Shared Neighborhood Hits	99
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1780)	NC score	0.114807 (rank : 1159)
Query Neighborhood Hits	1103	Target Neighborhood Hits	456	Shared Neighborhood Hits	93
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1781)	NC score	0.127752 (rank : 1134)
Query Neighborhood Hits	1103	Target Neighborhood Hits	398	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1782)	NC score	0.127435 (rank : 1136)
Query Neighborhood Hits	1103	Target Neighborhood Hits	404	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1783)	NC score	0.117861 (rank : 1153)
Query Neighborhood Hits	1103	Target Neighborhood Hits	452	Shared Neighborhood Hits	99
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1784)	NC score	0.110866 (rank : 1165)
Query Neighborhood Hits	1103	Target Neighborhood Hits	430	Shared Neighborhood Hits	96
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VINEX_HUMAN
θ value	θ > 10 (rank : 1785)	NC score	0.065606 (rank : 1334)
Query Neighborhood Hits	1103	Target Neighborhood Hits	270	Shared Neighborhood Hits	51
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 1786)	NC score	0.067974 (rank : 1308)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VRK1_HUMAN
θ value	θ > 10 (rank : 1787)	NC score	0.237478 (rank : 1060)
Query Neighborhood Hits	1103	Target Neighborhood Hits	584	Shared Neighborhood Hits	397
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
θ value	θ > 10 (rank : 1788)	NC score	0.249559 (rank : 1053)
Query Neighborhood Hits	1103	Target Neighborhood Hits	583	Shared Neighborhood Hits	402
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
θ value	θ > 10 (rank : 1789)	NC score	0.249877 (rank : 1052)
Query Neighborhood Hits	1103	Target Neighborhood Hits	582	Shared Neighborhood Hits	393
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_MOUSE
θ value	θ > 10 (rank : 1790)	NC score	0.240196 (rank : 1059)
Query Neighborhood Hits	1103	Target Neighborhood Hits	586	Shared Neighborhood Hits	394
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK3_HUMAN
θ value	θ > 10 (rank : 1791)	NC score	0.132242 (rank : 1131)
Query Neighborhood Hits	1103	Target Neighborhood Hits	349	Shared Neighborhood Hits	231
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WEE1B_HUMAN
θ value	θ > 10 (rank : 1792)	NC score	0.426759 (rank : 736)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	525
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1_HUMAN
θ value	θ > 10 (rank : 1793)	NC score	0.438345 (rank : 709)
Query Neighborhood Hits	1103	Target Neighborhood Hits	777	Shared Neighborhood Hits	510
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 1794)	NC score	0.458573 (rank : 632)
Query Neighborhood Hits	1103	Target Neighborhood Hits	794	Shared Neighborhood Hits	524
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

XE7_HUMAN
θ value	θ > 10 (rank : 1795)	NC score	0.053431 (rank : 1538)
Query Neighborhood Hits	1103	Target Neighborhood Hits	738	Shared Neighborhood Hits	127
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

Hits sorted by NC score

TEX14_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1103	Shared Neighborhood Hits	1103
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
NC score	0.939566 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1333	Shared Neighborhood Hits	888
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TNI3K_HUMAN
NC score	0.766278 (rank : 3)	θ value	1.29331e-14 (rank : 3)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1084	Shared Neighborhood Hits	778
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
NC score	0.762824 (rank : 4)	θ value	1.2105e-12 (rank : 13)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1079	Shared Neighborhood Hits	776
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ILK_MOUSE
NC score	0.751517 (rank : 5)	θ value	2.44474e-05 (rank : 229)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	687
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.750907 (rank : 6)	θ value	1.09739e-05 (rank : 197)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	684
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ANKK1_HUMAN
NC score	0.749819 (rank : 7)	θ value	7.59969e-07 (rank : 130)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1075	Shared Neighborhood Hits	775
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

RIPK4_HUMAN
NC score	0.745769 (rank : 8)	θ value	0.00175202 (rank : 411)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1094	Shared Neighborhood Hits	783
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ILK2_HUMAN
NC score	0.744583 (rank : 9)	θ value	0.000121331 (rank : 286)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	677
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ANKK1_MOUSE
NC score	0.744374 (rank : 10)	θ value	1.87187e-05 (rank : 211)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1072	Shared Neighborhood Hits	775
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

TNK1_HUMAN
NC score	0.698275 (rank : 11)	θ value	1.80886e-08 (rank : 89)
Query Neighborhood Hits	1103	Target Neighborhood Hits	815	Shared Neighborhood Hits	566
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
NC score	0.696791 (rank : 12)	θ value	1.25267e-09 (rank : 53)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	557
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

LTK_HUMAN
NC score	0.695014 (rank : 13)	θ value	1.29631e-06 (rank : 143)
Query Neighborhood Hits	1103	Target Neighborhood Hits	774	Shared Neighborhood Hits	545
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
NC score	0.693193 (rank : 14)	θ value	4.45536e-07 (rank : 120)
Query Neighborhood Hits	1103	Target Neighborhood Hits	770	Shared Neighborhood Hits	543
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ERBB4_HUMAN
NC score	0.691999 (rank : 15)	θ value	7.09661e-13 (rank : 9)
Query Neighborhood Hits	1103	Target Neighborhood Hits	910	Shared Neighborhood Hits	566
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EGFR_HUMAN
NC score	0.691767 (rank : 16)	θ value	2.98157e-11 (rank : 24)
Query Neighborhood Hits	1103	Target Neighborhood Hits	939	Shared Neighborhood Hits	566
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
NC score	0.691497 (rank : 17)	θ value	5.08577e-11 (rank : 27)
Query Neighborhood Hits	1103	Target Neighborhood Hits	927	Shared Neighborhood Hits	566
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.691184 (rank : 18)	θ value	1.80886e-08 (rank : 84)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	546
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
NC score	0.691184 (rank : 19)	θ value	6.21693e-09 (rank : 66)
Query Neighborhood Hits	1103	Target Neighborhood Hits	795	Shared Neighborhood Hits	542
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

TXK_HUMAN
NC score	0.690505 (rank : 20)	θ value	1.02475e-11 (rank : 23)
Query Neighborhood Hits	1103	Target Neighborhood Hits	971	Shared Neighborhood Hits	568
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ERBB2_MOUSE
NC score	0.690466 (rank : 21)	θ value	7.34386e-10 (rank : 44)
Query Neighborhood Hits	1103	Target Neighborhood Hits	918	Shared Neighborhood Hits	568
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB2_HUMAN
NC score	0.689722 (rank : 22)	θ value	5.62301e-10 (rank : 40)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1073	Shared Neighborhood Hits	574
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

TXK_MOUSE
NC score	0.689474 (rank : 23)	θ value	4.30538e-10 (rank : 39)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	571
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FAK2_HUMAN
NC score	0.689198 (rank : 24)	θ value	6.87365e-08 (rank : 97)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	569
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EPHA1_HUMAN
NC score	0.689103 (rank : 25)	θ value	5.08577e-11 (rank : 28)
Query Neighborhood Hits	1103	Target Neighborhood Hits	997	Shared Neighborhood Hits	575
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

ZAP70_HUMAN
NC score	0.688997 (rank : 26)	θ value	4.59992e-12 (rank : 18)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	564
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FAK2_MOUSE
NC score	0.687425 (rank : 27)	θ value	1.53129e-07 (rank : 104)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	569
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EPHA1_MOUSE
NC score	0.687313 (rank : 28)	θ value	6.64225e-11 (rank : 29)
Query Neighborhood Hits	1103	Target Neighborhood Hits	958	Shared Neighborhood Hits	570
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

ZAP70_MOUSE
NC score	0.687036 (rank : 29)	θ value	3.89403e-11 (rank : 25)
Query Neighborhood Hits	1103	Target Neighborhood Hits	905	Shared Neighborhood Hits	566
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FAK1_HUMAN
NC score	0.687014 (rank : 30)	θ value	1.80886e-08 (rank : 87)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	567
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
NC score	0.686983 (rank : 31)	θ value	1.80886e-08 (rank : 88)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	565
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ROS_HUMAN
NC score	0.686947 (rank : 32)	θ value	8.97725e-08 (rank : 99)
Query Neighborhood Hits	1103	Target Neighborhood Hits	907	Shared Neighborhood Hits	549
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

ACK1_HUMAN
NC score	0.686054 (rank : 33)	θ value	1.06045e-08 (rank : 71)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1140	Shared Neighborhood Hits	608
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
NC score	0.685976 (rank : 34)	θ value	1.06045e-08 (rank : 72)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1080	Shared Neighborhood Hits	598
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EPHA5_MOUSE
NC score	0.685631 (rank : 35)	θ value	1.06045e-08 (rank : 73)
Query Neighborhood Hits	1103	Target Neighborhood Hits	950	Shared Neighborhood Hits	571
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ITK_MOUSE
NC score	0.683040 (rank : 36)	θ value	1.25267e-09 (rank : 52)
Query Neighborhood Hits	1103	Target Neighborhood Hits	985	Shared Neighborhood Hits	571
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.682747 (rank : 37)	θ value	1.63604e-09 (rank : 55)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1016	Shared Neighborhood Hits	572
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MATK_HUMAN
NC score	0.682566 (rank : 38)	θ value	5.62301e-10 (rank : 41)
Query Neighborhood Hits	1103	Target Neighborhood Hits	954	Shared Neighborhood Hits	567
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ERBB3_HUMAN
NC score	0.682193 (rank : 39)	θ value	3.41135e-07 (rank : 112)
Query Neighborhood Hits	1103	Target Neighborhood Hits	918	Shared Neighborhood Hits	563
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

INSR_HUMAN
NC score	0.681427 (rank : 40)	θ value	2.13673e-09 (rank : 58)
Query Neighborhood Hits	1103	Target Neighborhood Hits	963	Shared Neighborhood Hits	569
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TEC_HUMAN
NC score	0.681227 (rank : 41)	θ value	9.59137e-10 (rank : 51)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1006	Shared Neighborhood Hits	574
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

KSYK_MOUSE
NC score	0.681090 (rank : 42)	θ value	1.86753e-13 (rank : 5)
Query Neighborhood Hits	1103	Target Neighborhood Hits	944	Shared Neighborhood Hits	565
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.681002 (rank : 43)	θ value	2.43908e-13 (rank : 6)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	562
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FRK_HUMAN
NC score	0.680998 (rank : 44)	θ value	2.88119e-14 (rank : 4)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1058	Shared Neighborhood Hits	579
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

INSR_MOUSE
NC score	0.680804 (rank : 45)	θ value	3.08544e-08 (rank : 91)
Query Neighborhood Hits	1103	Target Neighborhood Hits	968	Shared Neighborhood Hits	567
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TEC_MOUSE
NC score	0.679988 (rank : 46)	θ value	5.62301e-10 (rank : 42)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1006	Shared Neighborhood Hits	573
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

IGF1R_MOUSE
NC score	0.679327 (rank : 47)	θ value	4.45536e-07 (rank : 119)
Query Neighborhood Hits	1103	Target Neighborhood Hits	973	Shared Neighborhood Hits	561
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MATK_MOUSE
NC score	0.679314 (rank : 48)	θ value	5.26297e-08 (rank : 93)
Query Neighborhood Hits	1103	Target Neighborhood Hits	952	Shared Neighborhood Hits	568
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

IGF1R_HUMAN
NC score	0.679107 (rank : 49)	θ value	8.97725e-08 (rank : 98)
Query Neighborhood Hits	1103	Target Neighborhood Hits	977	Shared Neighborhood Hits	562
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

EPHA2_MOUSE
NC score	0.678451 (rank : 50)	θ value	1.80886e-08 (rank : 86)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1020	Shared Neighborhood Hits	566
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA2_HUMAN
NC score	0.678412 (rank : 51)	θ value	1.80886e-08 (rank : 85)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1021	Shared Neighborhood Hits	568
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

LCK_MOUSE
NC score	0.678295 (rank : 52)	θ value	9.59137e-10 (rank : 47)
Query Neighborhood Hits	1103	Target Neighborhood Hits	981	Shared Neighborhood Hits	574
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

ERBB3_MOUSE
NC score	0.677962 (rank : 53)	θ value	2.88788e-06 (rank : 165)
Query Neighborhood Hits	1103	Target Neighborhood Hits	898	Shared Neighborhood Hits	561
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ABL2_HUMAN
NC score	0.677112 (rank : 54)	θ value	5.08577e-11 (rank : 26)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1045	Shared Neighborhood Hits	579
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

LCK_HUMAN
NC score	0.677085 (rank : 55)	θ value	1.06045e-08 (rank : 74)
Query Neighborhood Hits	1103	Target Neighborhood Hits	987	Shared Neighborhood Hits	575
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SRMS_HUMAN
NC score	0.676705 (rank : 56)	θ value	4.45536e-07 (rank : 122)
Query Neighborhood Hits	1103	Target Neighborhood Hits	946	Shared Neighborhood Hits	570
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

EPHA8_HUMAN
NC score	0.676686 (rank : 57)	θ value	1.53129e-07 (rank : 103)
Query Neighborhood Hits	1103	Target Neighborhood Hits	956	Shared Neighborhood Hits	570
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
NC score	0.676515 (rank : 58)	θ value	4.45536e-07 (rank : 115)
Query Neighborhood Hits	1103	Target Neighborhood Hits	969	Shared Neighborhood Hits	570
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

HCK_MOUSE
NC score	0.676202 (rank : 59)	θ value	2.13673e-09 (rank : 57)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1029	Shared Neighborhood Hits	574
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

RET_HUMAN
NC score	0.676096 (rank : 60)	θ value	5.81887e-07 (rank : 129)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	560
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ABL1_HUMAN
NC score	0.676003 (rank : 61)	θ value	6.00763e-12 (rank : 19)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1220	Shared Neighborhood Hits	606
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.675784 (rank : 62)	θ value	1.02475e-11 (rank : 21)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1178	Shared Neighborhood Hits	599
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

INSRR_MOUSE
NC score	0.675750 (rank : 63)	θ value	5.81887e-07 (rank : 127)
Query Neighborhood Hits	1103	Target Neighborhood Hits	961	Shared Neighborhood Hits	562
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

YES_HUMAN
NC score	0.675674 (rank : 64)	θ value	1.47974e-10 (rank : 30)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1059	Shared Neighborhood Hits	576
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.675537 (rank : 65)	θ value	1.9326e-10 (rank : 33)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1052	Shared Neighborhood Hits	574
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPHB4_HUMAN
NC score	0.675535 (rank : 66)	θ value	3.77169e-06 (rank : 170)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1056	Shared Neighborhood Hits	575
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

CSK_HUMAN
NC score	0.675432 (rank : 67)	θ value	2.69671e-12 (rank : 16)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	571
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

EPHA5_HUMAN
NC score	0.675348 (rank : 68)	θ value	1.38499e-08 (rank : 83)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	574
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

BTK_MOUSE
NC score	0.675326 (rank : 69)	θ value	2.79066e-09 (rank : 61)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1017	Shared Neighborhood Hits	573
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

EPHA6_MOUSE
NC score	0.675254 (rank : 70)	θ value	4.92598e-06 (rank : 175)
Query Neighborhood Hits	1103	Target Neighborhood Hits	946	Shared Neighborhood Hits	568
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

RET_MOUSE
NC score	0.675145 (rank : 71)	θ value	9.92553e-07 (rank : 138)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	561
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

SRC_MOUSE
NC score	0.675075 (rank : 72)	θ value	4.30538e-10 (rank : 38)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1033	Shared Neighborhood Hits	572
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

STYK1_MOUSE
NC score	0.675037 (rank : 73)	θ value	0.000461057 (rank : 352)
Query Neighborhood Hits	1103	Target Neighborhood Hits	779	Shared Neighborhood Hits	545
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

FER_HUMAN
NC score	0.674989 (rank : 74)	θ value	1.69304e-06 (rank : 146)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1278	Shared Neighborhood Hits	636
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

BLK_HUMAN
NC score	0.674985 (rank : 75)	θ value	2.88788e-06 (rank : 163)
Query Neighborhood Hits	1103	Target Neighborhood Hits	994	Shared Neighborhood Hits	575
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_HUMAN
NC score	0.674914 (rank : 76)	θ value	2.13673e-09 (rank : 56)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	574
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

EPHB4_MOUSE
NC score	0.674713 (rank : 77)	θ value	4.92598e-06 (rank : 176)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1013	Shared Neighborhood Hits	571
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FGR_MOUSE
NC score	0.674663 (rank : 78)	θ value	1.02475e-11 (rank : 22)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1069	Shared Neighborhood Hits	576
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

STYK1_HUMAN
NC score	0.674569 (rank : 79)	θ value	1.09739e-05 (rank : 200)
Query Neighborhood Hits	1103	Target Neighborhood Hits	786	Shared Neighborhood Hits	547
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

INSRR_HUMAN
NC score	0.674460 (rank : 80)	θ value	9.92553e-07 (rank : 134)
Query Neighborhood Hits	1103	Target Neighborhood Hits	950	Shared Neighborhood Hits	561
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

EPHA6_HUMAN
NC score	0.674381 (rank : 81)	θ value	2.21117e-06 (rank : 156)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	565
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

HCK_HUMAN
NC score	0.674047 (rank : 82)	θ value	6.21693e-09 (rank : 69)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1035	Shared Neighborhood Hits	572
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

UFO_MOUSE
NC score	0.673986 (rank : 83)	θ value	3.52202e-12 (rank : 17)
Query Neighborhood Hits	1103	Target Neighborhood Hits	988	Shared Neighborhood Hits	553
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

CSK_MOUSE
NC score	0.673979 (rank : 84)	θ value	5.43371e-13 (rank : 7)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	571
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

RON_MOUSE
NC score	0.673976 (rank : 85)	θ value	7.1131e-05 (rank : 273)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	561
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FES_MOUSE
NC score	0.673832 (rank : 86)	θ value	0.00134147 (rank : 380)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	588
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

EPHB2_HUMAN
NC score	0.673558 (rank : 87)	θ value	4.45536e-07 (rank : 116)
Query Neighborhood Hits	1103	Target Neighborhood Hits	983	Shared Neighborhood Hits	568
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

RON_HUMAN
NC score	0.673538 (rank : 88)	θ value	0.000121331 (rank : 290)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

BLK_MOUSE
NC score	0.673454 (rank : 89)	θ value	3.19293e-05 (rank : 240)
Query Neighborhood Hits	1103	Target Neighborhood Hits	992	Shared Neighborhood Hits	574
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EPHB2_MOUSE
NC score	0.673449 (rank : 90)	θ value	4.45536e-07 (rank : 117)
Query Neighborhood Hits	1103	Target Neighborhood Hits	982	Shared Neighborhood Hits	568
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

PTK6_MOUSE
NC score	0.673421 (rank : 91)	θ value	9.59137e-10 (rank : 50)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	574
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

UFO_HUMAN
NC score	0.673386 (rank : 92)	θ value	5.62301e-10 (rank : 43)
Query Neighborhood Hits	1103	Target Neighborhood Hits	981	Shared Neighborhood Hits	549
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

MLKL_MOUSE
NC score	0.673371 (rank : 93)	θ value	5.26297e-08 (rank : 94)
Query Neighborhood Hits	1103	Target Neighborhood Hits	707	Shared Neighborhood Hits	524
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

SRC_HUMAN
NC score	0.673257 (rank : 94)	θ value	2.52405e-10 (rank : 35)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1058	Shared Neighborhood Hits	572
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.673221 (rank : 95)	θ value	2.52405e-10 (rank : 34)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1073	Shared Neighborhood Hits	576
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

EPHB1_HUMAN
NC score	0.673090 (rank : 96)	θ value	2.61198e-07 (rank : 109)
Query Neighborhood Hits	1103	Target Neighborhood Hits	988	Shared Neighborhood Hits	571
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

SRMS_MOUSE
NC score	0.673086 (rank : 97)	θ value	2.88788e-06 (rank : 168)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	567
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

EPHA3_HUMAN
NC score	0.672927 (rank : 98)	θ value	4.76016e-09 (rank : 65)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1005	Shared Neighborhood Hits	569
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA4_HUMAN
NC score	0.672847 (rank : 99)	θ value	1.99992e-07 (rank : 105)
Query Neighborhood Hits	1103	Target Neighborhood Hits	975	Shared Neighborhood Hits	573
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.672795 (rank : 100)	θ value	1.53129e-07 (rank : 102)
Query Neighborhood Hits	1103	Target Neighborhood Hits	982	Shared Neighborhood Hits	573
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

FES_HUMAN
NC score	0.672417 (rank : 101)	θ value	0.00102713 (rank : 364)
Query Neighborhood Hits	1103	Target Neighborhood Hits	978	Shared Neighborhood Hits	579
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

BMX_MOUSE
NC score	0.672402 (rank : 102)	θ value	2.21117e-06 (rank : 154)
Query Neighborhood Hits	1103	Target Neighborhood Hits	912	Shared Neighborhood Hits	559
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

EPHB6_MOUSE
NC score	0.672377 (rank : 103)	θ value	1.63604e-09 (rank : 54)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	540
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

PTK6_HUMAN
NC score	0.672309 (rank : 104)	θ value	6.21693e-09 (rank : 70)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1020	Shared Neighborhood Hits	574
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

LYN_HUMAN
NC score	0.672283 (rank : 105)	θ value	9.59137e-10 (rank : 48)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1022	Shared Neighborhood Hits	576
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.672257 (rank : 106)	θ value	7.34386e-10 (rank : 45)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	576
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

EPHB3_HUMAN
NC score	0.672257 (rank : 107)	θ value	8.40245e-06 (rank : 188)
Query Neighborhood Hits	1103	Target Neighborhood Hits	996	Shared Neighborhood Hits	570
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

FGR_HUMAN
NC score	0.672216 (rank : 108)	θ value	9.59137e-10 (rank : 46)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1067	Shared Neighborhood Hits	576
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MERTK_MOUSE
NC score	0.672069 (rank : 109)	θ value	1.06045e-08 (rank : 77)
Query Neighborhood Hits	1103	Target Neighborhood Hits	974	Shared Neighborhood Hits	553
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

EPHB6_HUMAN
NC score	0.671884 (rank : 110)	θ value	1.9326e-10 (rank : 31)
Query Neighborhood Hits	1103	Target Neighborhood Hits	912	Shared Neighborhood Hits	536
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHA3_MOUSE
NC score	0.671706 (rank : 111)	θ value	4.0297e-08 (rank : 92)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	569
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA7_MOUSE
NC score	0.671621 (rank : 112)	θ value	2.36244e-08 (rank : 90)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1025	Shared Neighborhood Hits	567
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB3_MOUSE
NC score	0.671523 (rank : 113)	θ value	8.40245e-06 (rank : 189)
Query Neighborhood Hits	1103	Target Neighborhood Hits	996	Shared Neighborhood Hits	569
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

BMX_HUMAN
NC score	0.671275 (rank : 114)	θ value	1.43324e-05 (rank : 203)
Query Neighborhood Hits	1103	Target Neighborhood Hits	942	Shared Neighborhood Hits	561
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

NTRK1_HUMAN
NC score	0.670855 (rank : 115)	θ value	2.44474e-05 (rank : 233)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	553
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EPHA7_HUMAN
NC score	0.670838 (rank : 116)	θ value	6.87365e-08 (rank : 96)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1053	Shared Neighborhood Hits	571
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

MET_HUMAN
NC score	0.670735 (rank : 117)	θ value	1.87187e-05 (rank : 220)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	561
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RYK_MOUSE
NC score	0.669806 (rank : 118)	θ value	0.00509761 (rank : 466)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	521
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

FYN_HUMAN
NC score	0.669801 (rank : 119)	θ value	3.29651e-10 (rank : 36)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1078	Shared Neighborhood Hits	575
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

MET_MOUSE
NC score	0.669494 (rank : 120)	θ value	0.000270298 (rank : 326)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	561
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RYK_HUMAN
NC score	0.668080 (rank : 121)	θ value	0.0148317 (rank : 530)
Query Neighborhood Hits	1103	Target Neighborhood Hits	701	Shared Neighborhood Hits	515
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

EPHAA_HUMAN
NC score	0.667848 (rank : 122)	θ value	7.1131e-05 (rank : 269)
Query Neighborhood Hits	1103	Target Neighborhood Hits	960	Shared Neighborhood Hits	559
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MERTK_HUMAN
NC score	0.667720 (rank : 123)	θ value	2.61198e-07 (rank : 110)
Query Neighborhood Hits	1103	Target Neighborhood Hits	988	Shared Neighborhood Hits	551
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

DDR1_MOUSE
NC score	0.666979 (rank : 124)	θ value	1.87187e-05 (rank : 213)
Query Neighborhood Hits	1103	Target Neighborhood Hits	818	Shared Neighborhood Hits	549
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.665914 (rank : 125)	θ value	1.87187e-05 (rank : 212)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	549
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

JAK1_HUMAN
NC score	0.662591 (rank : 126)	θ value	2.88788e-06 (rank : 166)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	569
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
NC score	0.662503 (rank : 127)	θ value	2.21117e-06 (rank : 157)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	567
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TYRO3_MOUSE
NC score	0.661945 (rank : 128)	θ value	1.29631e-06 (rank : 144)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1007	Shared Neighborhood Hits	554
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ROR1_HUMAN
NC score	0.661516 (rank : 129)	θ value	9.29e-05 (rank : 283)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1018	Shared Neighborhood Hits	565
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TYRO3_HUMAN
NC score	0.661037 (rank : 130)	θ value	9.92553e-07 (rank : 139)
Query Neighborhood Hits	1103	Target Neighborhood Hits	995	Shared Neighborhood Hits	552
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

ROR1_MOUSE
NC score	0.660861 (rank : 131)	θ value	0.000121331 (rank : 291)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1025	Shared Neighborhood Hits	565
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

NTRK3_HUMAN
NC score	0.660524 (rank : 132)	θ value	9.59137e-10 (rank : 49)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1115	Shared Neighborhood Hits	559
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

DDR2_MOUSE
NC score	0.659745 (rank : 133)	θ value	0.00035302 (rank : 334)
Query Neighborhood Hits	1103	Target Neighborhood Hits	813	Shared Neighborhood Hits	555
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

M3KL4_HUMAN
NC score	0.659699 (rank : 134)	θ value	1.58096e-12 (rank : 15)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1087	Shared Neighborhood Hits	594
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

NTRK2_MOUSE
NC score	0.659327 (rank : 135)	θ value	2.79066e-09 (rank : 62)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1088	Shared Neighborhood Hits	558
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.659313 (rank : 136)	θ value	3.64472e-09 (rank : 63)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1081	Shared Neighborhood Hits	558
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

DDR2_HUMAN
NC score	0.658220 (rank : 137)	θ value	0.00134147 (rank : 379)
Query Neighborhood Hits	1103	Target Neighborhood Hits	818	Shared Neighborhood Hits	552
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

M3K10_HUMAN
NC score	0.656922 (rank : 138)	θ value	6.00763e-12 (rank : 20)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1071	Shared Neighborhood Hits	585
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ROR2_HUMAN
NC score	0.656603 (rank : 139)	θ value	0.000270298 (rank : 329)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1014	Shared Neighborhood Hits	565
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

M3K11_HUMAN
NC score	0.655636 (rank : 140)	θ value	5.43371e-13 (rank : 8)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1136	Shared Neighborhood Hits	591
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
NC score	0.655477 (rank : 141)	θ value	1.58096e-12 (rank : 14)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1123	Shared Neighborhood Hits	592
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

FLT3_HUMAN
NC score	0.654572 (rank : 142)	θ value	4.1701e-05 (rank : 245)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	556
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

M3K12_HUMAN
NC score	0.654439 (rank : 143)	θ value	1.2105e-12 (rank : 11)
Query Neighborhood Hits	1103	Target Neighborhood Hits	940	Shared Neighborhood Hits	576
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.654317 (rank : 144)	θ value	1.2105e-12 (rank : 12)
Query Neighborhood Hits	1103	Target Neighborhood Hits	957	Shared Neighborhood Hits	579
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

MLTK_MOUSE
NC score	0.654272 (rank : 145)	θ value	1.9326e-10 (rank : 32)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	570
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.653987 (rank : 146)	θ value	4.30538e-10 (rank : 37)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	575
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

JAK2_MOUSE
NC score	0.653780 (rank : 147)	θ value	2.21117e-06 (rank : 158)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	567
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_HUMAN
NC score	0.653691 (rank : 148)	θ value	1.69304e-06 (rank : 147)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	567
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ROR2_MOUSE
NC score	0.653620 (rank : 149)	θ value	0.00298849 (rank : 443)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1000	Shared Neighborhood Hits	559
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

FLT3_MOUSE
NC score	0.652790 (rank : 150)	θ value	3.19293e-05 (rank : 242)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	557
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

TYK2_MOUSE
NC score	0.652110 (rank : 151)	θ value	5.44631e-05 (rank : 264)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	568
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

FGFR4_MOUSE
NC score	0.651525 (rank : 152)	θ value	4.45536e-07 (rank : 118)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	560
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

M3K13_HUMAN
NC score	0.651492 (rank : 153)	θ value	7.09661e-13 (rank : 10)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	572
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

TYK2_HUMAN
NC score	0.651379 (rank : 154)	θ value	5.44631e-05 (rank : 263)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	567
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

FGFR4_HUMAN
NC score	0.651240 (rank : 155)	θ value	3.41135e-07 (rank : 113)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1037	Shared Neighborhood Hits	562
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

JAK3_HUMAN
NC score	0.649185 (rank : 156)	θ value	0.00228821 (rank : 421)
Query Neighborhood Hits	1103	Target Neighborhood Hits	827	Shared Neighborhood Hits	565
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

FGFR2_MOUSE
NC score	0.649059 (rank : 157)	θ value	4.92598e-06 (rank : 178)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1062	Shared Neighborhood Hits	564
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
NC score	0.648845 (rank : 158)	θ value	1.09739e-05 (rank : 195)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1042	Shared Neighborhood Hits	565
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR2_HUMAN
NC score	0.646961 (rank : 159)	θ value	4.92598e-06 (rank : 177)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1062	Shared Neighborhood Hits	564
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

KIT_HUMAN
NC score	0.646668 (rank : 160)	θ value	0.00390308 (rank : 449)
Query Neighborhood Hits	1103	Target Neighborhood Hits	953	Shared Neighborhood Hits	556
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

TIE2_HUMAN
NC score	0.646373 (rank : 161)	θ value	0.000121331 (rank : 293)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1192	Shared Neighborhood Hits	567
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

FGFR3_MOUSE
NC score	0.646271 (rank : 162)	θ value	2.44474e-05 (rank : 228)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1059	Shared Neighborhood Hits	565
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

TIE2_MOUSE
NC score	0.646057 (rank : 163)	θ value	0.000158464 (rank : 303)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1204	Shared Neighborhood Hits	567
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

PGFRB_HUMAN
NC score	0.644857 (rank : 164)	θ value	9.29e-05 (rank : 282)
Query Neighborhood Hits	1103	Target Neighborhood Hits	962	Shared Neighborhood Hits	555
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

CSF1R_HUMAN
NC score	0.644437 (rank : 165)	θ value	0.000158464 (rank : 297)
Query Neighborhood Hits	1103	Target Neighborhood Hits	943	Shared Neighborhood Hits	554
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

KIT_MOUSE
NC score	0.644367 (rank : 166)	θ value	0.00390308 (rank : 450)
Query Neighborhood Hits	1103	Target Neighborhood Hits	949	Shared Neighborhood Hits	556
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

FGFR1_MOUSE
NC score	0.643445 (rank : 167)	θ value	5.44631e-05 (rank : 256)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1068	Shared Neighborhood Hits	565
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.643341 (rank : 168)	θ value	5.44631e-05 (rank : 255)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1069	Shared Neighborhood Hits	565
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

JAK3_MOUSE
NC score	0.642578 (rank : 169)	θ value	0.000121331 (rank : 287)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	558
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

PGFRB_MOUSE
NC score	0.642561 (rank : 170)	θ value	0.00035302 (rank : 340)
Query Neighborhood Hits	1103	Target Neighborhood Hits	960	Shared Neighborhood Hits	556
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

M3K7_MOUSE
NC score	0.639584 (rank : 171)	θ value	1.06045e-08 (rank : 76)
Query Neighborhood Hits	1103	Target Neighborhood Hits	892	Shared Neighborhood Hits	573
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.639494 (rank : 172)	θ value	1.06045e-08 (rank : 75)
Query Neighborhood Hits	1103	Target Neighborhood Hits	892	Shared Neighborhood Hits	572
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

TIE1_HUMAN
NC score	0.638933 (rank : 173)	θ value	0.00298849 (rank : 444)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1241	Shared Neighborhood Hits	563
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

AATK_MOUSE
NC score	0.638439 (rank : 174)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	1103	Target Neighborhood Hits	942	Shared Neighborhood Hits	552
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

CSF1R_MOUSE
NC score	0.638434 (rank : 175)	θ value	3.19293e-05 (rank : 241)
Query Neighborhood Hits	1103	Target Neighborhood Hits	983	Shared Neighborhood Hits	555
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TIE1_MOUSE
NC score	0.638258 (rank : 176)	θ value	0.00390308 (rank : 458)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1266	Shared Neighborhood Hits	566
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

BRAF1_HUMAN
NC score	0.637495 (rank : 177)	θ value	7.1131e-05 (rank : 267)
Query Neighborhood Hits	1103	Target Neighborhood Hits	883	Shared Neighborhood Hits	568
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

RAF1_HUMAN
NC score	0.636966 (rank : 178)	θ value	2.88788e-06 (rank : 167)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	570
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ARAF_MOUSE
NC score	0.636097 (rank : 179)	θ value	0.0113563 (rank : 494)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	568
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

MLKL_HUMAN
NC score	0.635631 (rank : 180)	θ value	0.00020696 (rank : 311)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	444
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RAF1_MOUSE
NC score	0.634426 (rank : 181)	θ value	1.43324e-05 (rank : 209)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	570
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ARAF_HUMAN
NC score	0.634322 (rank : 182)	θ value	0.0252991 (rank : 551)
Query Neighborhood Hits	1103	Target Neighborhood Hits	924	Shared Neighborhood Hits	576
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PGFRA_MOUSE
NC score	0.633661 (rank : 183)	θ value	1.06291 (rank : 800)
Query Neighborhood Hits	1103	Target Neighborhood Hits	975	Shared Neighborhood Hits	558
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TESK2_MOUSE
NC score	0.633534 (rank : 184)	θ value	2.61198e-07 (rank : 111)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	563
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

AATK_HUMAN
NC score	0.633446 (rank : 185)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1243	Shared Neighborhood Hits	581
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

PGFRA_HUMAN
NC score	0.633177 (rank : 186)	θ value	1.06291 (rank : 799)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	558
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TESK2_HUMAN
NC score	0.633117 (rank : 187)	θ value	1.99992e-07 (rank : 107)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	564
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

DAPK1_MOUSE
NC score	0.629798 (rank : 188)	θ value	2.88788e-06 (rank : 164)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1138	Shared Neighborhood Hits	783
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

TESK1_MOUSE
NC score	0.628507 (rank : 189)	θ value	1.06045e-08 (rank : 78)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	568
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_HUMAN
NC score	0.627646 (rank : 190)	θ value	1.17247e-07 (rank : 101)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	570
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

VGFR3_HUMAN
NC score	0.627572 (rank : 191)	θ value	0.00134147 (rank : 394)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1037	Shared Neighborhood Hits	558
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

RIPK1_HUMAN
NC score	0.627181 (rank : 192)	θ value	8.40245e-06 (rank : 191)
Query Neighborhood Hits	1103	Target Neighborhood Hits	891	Shared Neighborhood Hits	572
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
NC score	0.626583 (rank : 193)	θ value	0.00134147 (rank : 390)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	574
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

DAPK1_HUMAN
NC score	0.626390 (rank : 194)	θ value	2.44474e-05 (rank : 227)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1130	Shared Neighborhood Hits	781
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

VGFR3_MOUSE
NC score	0.625696 (rank : 195)	θ value	0.00175202 (rank : 414)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1056	Shared Neighborhood Hits	556
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

MOS_HUMAN
NC score	0.624997 (rank : 196)	θ value	0.0193708 (rank : 545)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	566
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
NC score	0.620506 (rank : 197)	θ value	4.1701e-05 (rank : 249)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	566
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MUSK_HUMAN
NC score	0.618519 (rank : 198)	θ value	0.0113563 (rank : 505)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1074	Shared Neighborhood Hits	554
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

IRAK3_MOUSE
NC score	0.618245 (rank : 199)	θ value	7.59969e-07 (rank : 131)
Query Neighborhood Hits	1103	Target Neighborhood Hits	628	Shared Neighborhood Hits	475
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MUSK_MOUSE
NC score	0.618192 (rank : 200)	θ value	0.0431538 (rank : 599)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1057	Shared Neighborhood Hits	553
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

RIPK2_MOUSE
NC score	0.615853 (rank : 201)	θ value	1.87187e-05 (rank : 222)
Query Neighborhood Hits	1103	Target Neighborhood Hits	776	Shared Neighborhood Hits	535
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

VGFR2_MOUSE
NC score	0.614112 (rank : 202)	θ value	0.00228821 (rank : 431)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1089	Shared Neighborhood Hits	558
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

KSR1_MOUSE
NC score	0.613810 (rank : 203)	θ value	4.03905 (rank : 958)
Query Neighborhood Hits	1103	Target Neighborhood Hits	870	Shared Neighborhood Hits	563
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

RIPK2_HUMAN
NC score	0.613615 (rank : 204)	θ value	0.00035302 (rank : 341)
Query Neighborhood Hits	1103	Target Neighborhood Hits	774	Shared Neighborhood Hits	538
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

IRAK4_HUMAN
NC score	0.612429 (rank : 205)	θ value	0.00175202 (rank : 403)
Query Neighborhood Hits	1103	Target Neighborhood Hits	816	Shared Neighborhood Hits	560
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

PTK7_HUMAN
NC score	0.611056 (rank : 206)	θ value	6.43352e-06 (rank : 186)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1103	Shared Neighborhood Hits	559
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

VGFR1_MOUSE
NC score	0.610992 (rank : 207)	θ value	0.000602161 (rank : 357)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1118	Shared Neighborhood Hits	557
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
NC score	0.610742 (rank : 208)	θ value	0.00228821 (rank : 430)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1103	Shared Neighborhood Hits	559
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

KSR1_HUMAN
NC score	0.610220 (rank : 209)	θ value	θ > 10 (rank : 1441)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	563
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

VGFR1_HUMAN
NC score	0.608538 (rank : 210)	θ value	0.00298849 (rank : 445)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1109	Shared Neighborhood Hits	557
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

IRAK3_HUMAN
NC score	0.606608 (rank : 211)	θ value	2.44474e-05 (rank : 230)
Query Neighborhood Hits	1103	Target Neighborhood Hits	644	Shared Neighborhood Hits	485
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KSR2_HUMAN
NC score	0.604635 (rank : 212)	θ value	3.0926 (rank : 921)
Query Neighborhood Hits	1103	Target Neighborhood Hits	920	Shared Neighborhood Hits	567
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

IRAK4_MOUSE
NC score	0.603888 (rank : 213)	θ value	0.00298849 (rank : 438)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	563
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

LIMK1_MOUSE
NC score	0.603103 (rank : 214)	θ value	3.77169e-06 (rank : 173)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1008	Shared Neighborhood Hits	572
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK1_HUMAN
NC score	0.602393 (rank : 215)	θ value	7.1131e-05 (rank : 270)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1005	Shared Neighborhood Hits	571
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

RIPK3_HUMAN
NC score	0.601670 (rank : 216)	θ value	3.0926 (rank : 935)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	565
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

LIMK2_HUMAN
NC score	0.599023 (rank : 217)	θ value	0.0193708 (rank : 535)
Query Neighborhood Hits	1103	Target Neighborhood Hits	986	Shared Neighborhood Hits	568
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
NC score	0.597498 (rank : 218)	θ value	0.0193708 (rank : 536)
Query Neighborhood Hits	1103	Target Neighborhood Hits	998	Shared Neighborhood Hits	570
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRK1_MOUSE
NC score	0.591675 (rank : 219)	θ value	0.0736092 (rank : 626)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1267	Shared Neighborhood Hits	668
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

IRAK1_HUMAN
NC score	0.591317 (rank : 220)	θ value	0.365318 (rank : 719)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	547
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
NC score	0.590182 (rank : 221)	θ value	1.38821 (rank : 824)
Query Neighborhood Hits	1103	Target Neighborhood Hits	784	Shared Neighborhood Hits	534
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

GUC2F_HUMAN
NC score	0.578290 (rank : 222)	θ value	0.000270298 (rank : 324)
Query Neighborhood Hits	1103	Target Neighborhood Hits	740	Shared Neighborhood Hits	521
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

LRRK1_HUMAN
NC score	0.578042 (rank : 223)	θ value	0.0961366 (rank : 638)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1237	Shared Neighborhood Hits	642
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

RIPK5_MOUSE
NC score	0.577019 (rank : 224)	θ value	0.365318 (rank : 731)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	574
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RIPK5_HUMAN
NC score	0.576940 (rank : 225)	θ value	0.47712 (rank : 750)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	574
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK3_MOUSE
NC score	0.571277 (rank : 226)	θ value	θ > 10 (rank : 1614)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	568
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

GUC2C_HUMAN
NC score	0.570392 (rank : 227)	θ value	0.62314 (rank : 758)
Query Neighborhood Hits	1103	Target Neighborhood Hits	624	Shared Neighborhood Hits	468
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

YSK4_HUMAN
NC score	0.569983 (rank : 228)	θ value	0.000121331 (rank : 295)
Query Neighborhood Hits	1103	Target Neighborhood Hits	921	Shared Neighborhood Hits	583
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

TOPK_HUMAN
NC score	0.564898 (rank : 229)	θ value	θ > 10 (rank : 1741)
Query Neighborhood Hits	1103	Target Neighborhood Hits	605	Shared Neighborhood Hits	453
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

STK24_MOUSE
NC score	0.564298 (rank : 230)	θ value	1.09739e-05 (rank : 199)
Query Neighborhood Hits	1103	Target Neighborhood Hits	856	Shared Neighborhood Hits	567
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK24_HUMAN
NC score	0.563465 (rank : 231)	θ value	6.43352e-06 (rank : 187)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	568
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

NEK11_HUMAN
NC score	0.563104 (rank : 232)	θ value	0.00175202 (rank : 405)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1043	Shared Neighborhood Hits	608
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
NC score	0.562258 (rank : 233)	θ value	0.0193708 (rank : 546)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	569
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK39_HUMAN
NC score	0.562025 (rank : 234)	θ value	0.000158464 (rank : 301)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	574
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

OXSR1_HUMAN
NC score	0.561979 (rank : 235)	θ value	5.81887e-07 (rank : 128)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	573
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_MOUSE
NC score	0.561899 (rank : 236)	θ value	0.000158464 (rank : 302)
Query Neighborhood Hits	1103	Target Neighborhood Hits	915	Shared Neighborhood Hits	581
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TOPK_MOUSE
NC score	0.561606 (rank : 237)	θ value	θ > 10 (rank : 1742)
Query Neighborhood Hits	1103	Target Neighborhood Hits	618	Shared Neighborhood Hits	464
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

OXSR1_MOUSE
NC score	0.560614 (rank : 238)	θ value	2.44474e-05 (rank : 234)
Query Neighborhood Hits	1103	Target Neighborhood Hits	865	Shared Neighborhood Hits	572
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

MST4_HUMAN
NC score	0.558802 (rank : 239)	θ value	0.00020696 (rank : 312)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	570
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
NC score	0.558620 (rank : 240)	θ value	0.00020696 (rank : 313)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	570
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK25_MOUSE
NC score	0.558410 (rank : 241)	θ value	7.1131e-05 (rank : 274)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	569
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

RN5A_MOUSE
NC score	0.558252 (rank : 242)	θ value	1.99992e-07 (rank : 106)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	657
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

STK25_HUMAN
NC score	0.557849 (rank : 243)	θ value	0.000121331 (rank : 292)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	570
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NEK7_HUMAN
NC score	0.551021 (rank : 244)	θ value	0.00390308 (rank : 455)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	569
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
NC score	0.550790 (rank : 245)	θ value	0.00665767 (rank : 477)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	568
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK4_MOUSE
NC score	0.549694 (rank : 246)	θ value	4.1701e-05 (rank : 250)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	575
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK4_HUMAN
NC score	0.547331 (rank : 247)	θ value	0.00035302 (rank : 339)
Query Neighborhood Hits	1103	Target Neighborhood Hits	883	Shared Neighborhood Hits	568
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

IKKB_HUMAN
NC score	0.546982 (rank : 248)	θ value	0.000158464 (rank : 299)
Query Neighborhood Hits	1103	Target Neighborhood Hits	980	Shared Neighborhood Hits	595
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKA_HUMAN
NC score	0.546112 (rank : 249)	θ value	0.62314 (rank : 760)
Query Neighborhood Hits	1103	Target Neighborhood Hits	863	Shared Neighborhood Hits	565
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NEK6_HUMAN
NC score	0.545595 (rank : 250)	θ value	0.0148317 (rank : 526)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	568
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.545374 (rank : 251)	θ value	0.0193708 (rank : 547)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	568
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

ULK1_MOUSE
NC score	0.544821 (rank : 252)	θ value	4.45536e-07 (rank : 123)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1214	Shared Neighborhood Hits	608
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

STK4_MOUSE
NC score	0.544787 (rank : 253)	θ value	0.0252991 (rank : 569)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	575
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

IKKA_MOUSE
NC score	0.544510 (rank : 254)	θ value	0.365318 (rank : 718)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	568
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

STK4_HUMAN
NC score	0.544499 (rank : 255)	θ value	0.0252991 (rank : 568)
Query Neighborhood Hits	1103	Target Neighborhood Hits	870	Shared Neighborhood Hits	572
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

ULK1_HUMAN
NC score	0.544391 (rank : 256)	θ value	2.21117e-06 (rank : 162)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1121	Shared Neighborhood Hits	595
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

IKKB_MOUSE
NC score	0.543666 (rank : 257)	θ value	0.00020696 (rank : 310)
Query Neighborhood Hits	1103	Target Neighborhood Hits	984	Shared Neighborhood Hits	591
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

STK3_MOUSE
NC score	0.542945 (rank : 258)	θ value	0.0252991 (rank : 567)
Query Neighborhood Hits	1103	Target Neighborhood Hits	869	Shared Neighborhood Hits	573
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK3_HUMAN
NC score	0.542158 (rank : 259)	θ value	0.0330416 (rank : 584)
Query Neighborhood Hits	1103	Target Neighborhood Hits	861	Shared Neighborhood Hits	571
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

ULK2_MOUSE
NC score	0.540108 (rank : 260)	θ value	0.000786445 (rank : 363)
Query Neighborhood Hits	1103	Target Neighborhood Hits	943	Shared Neighborhood Hits	582
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

TAOK2_HUMAN
NC score	0.539621 (rank : 261)	θ value	0.0431538 (rank : 601)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1172	Shared Neighborhood Hits	631
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

STK16_HUMAN
NC score	0.539313 (rank : 262)	θ value	0.00134147 (rank : 391)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	554
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

ULK2_HUMAN
NC score	0.539254 (rank : 263)	θ value	0.00228821 (rank : 429)
Query Neighborhood Hits	1103	Target Neighborhood Hits	979	Shared Neighborhood Hits	588
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

CI096_HUMAN
NC score	0.539205 (rank : 264)	θ value	0.000270298 (rank : 321)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	552
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

NEK1_MOUSE
NC score	0.538936 (rank : 265)	θ value	0.0148317 (rank : 525)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1311	Shared Neighborhood Hits	697
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

LRRK2_HUMAN
NC score	0.538724 (rank : 266)	θ value	1.69304e-06 (rank : 149)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1382	Shared Neighborhood Hits	580
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

E2AK2_MOUSE
NC score	0.538075 (rank : 267)	θ value	0.0736092 (rank : 623)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	563
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK2_HUMAN
NC score	0.537554 (rank : 268)	θ value	0.365318 (rank : 716)
Query Neighborhood Hits	1103	Target Neighborhood Hits	856	Shared Neighborhood Hits	560
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

M3K3_HUMAN
NC score	0.537505 (rank : 269)	θ value	0.00134147 (rank : 385)
Query Neighborhood Hits	1103	Target Neighborhood Hits	885	Shared Neighborhood Hits	567
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

STK16_MOUSE
NC score	0.536686 (rank : 270)	θ value	0.00020696 (rank : 317)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	552
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

TAOK2_MOUSE
NC score	0.536555 (rank : 271)	θ value	0.0252991 (rank : 570)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1373	Shared Neighborhood Hits	651
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

M3K3_MOUSE
NC score	0.536142 (rank : 272)	θ value	0.00390308 (rank : 451)
Query Neighborhood Hits	1103	Target Neighborhood Hits	876	Shared Neighborhood Hits	567
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MP2K5_MOUSE
NC score	0.534343 (rank : 273)	θ value	θ > 10 (rank : 1492)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	564
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PAK7_HUMAN
NC score	0.534247 (rank : 274)	θ value	9.92553e-07 (rank : 136)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	566
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

M3K2_HUMAN
NC score	0.534191 (rank : 275)	θ value	0.00035302 (rank : 336)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	563
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PAK7_MOUSE
NC score	0.533944 (rank : 276)	θ value	9.92553e-07 (rank : 137)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	566
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

NEK1_HUMAN
NC score	0.532979 (rank : 277)	θ value	0.0148317 (rank : 524)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1129	Shared Neighborhood Hits	633
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

PAK6_HUMAN
NC score	0.532536 (rank : 278)	θ value	6.43352e-06 (rank : 185)
Query Neighborhood Hits	1103	Target Neighborhood Hits	915	Shared Neighborhood Hits	577
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK2_MOUSE
NC score	0.531425 (rank : 279)	θ value	1.69304e-06 (rank : 151)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	572
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK2_HUMAN
NC score	0.531280 (rank : 280)	θ value	1.69304e-06 (rank : 150)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	574
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

LRRK2_MOUSE
NC score	0.531175 (rank : 281)	θ value	3.77169e-06 (rank : 174)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1359	Shared Neighborhood Hits	582
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

MP2K5_HUMAN
NC score	0.529995 (rank : 282)	θ value	θ > 10 (rank : 1491)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	562
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

GUC2E_MOUSE
NC score	0.529991 (rank : 283)	θ value	9.29e-05 (rank : 279)
Query Neighborhood Hits	1103	Target Neighborhood Hits	692	Shared Neighborhood Hits	504
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

NEK2_HUMAN
NC score	0.529977 (rank : 284)	θ value	0.0563607 (rank : 612)
Query Neighborhood Hits	1103	Target Neighborhood Hits	908	Shared Neighborhood Hits	580
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

ULK3_HUMAN
NC score	0.529922 (rank : 285)	θ value	0.00509761 (rank : 468)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	559
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

M3K1_MOUSE
NC score	0.529894 (rank : 286)	θ value	0.47712 (rank : 744)
Query Neighborhood Hits	1103	Target Neighborhood Hits	952	Shared Neighborhood Hits	577
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

E2AK3_HUMAN
NC score	0.529395 (rank : 287)	θ value	0.00175202 (rank : 402)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	565
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

TAOK3_MOUSE
NC score	0.529193 (rank : 288)	θ value	0.00390308 (rank : 457)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1458	Shared Neighborhood Hits	673
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAOK1_HUMAN
NC score	0.529104 (rank : 289)	θ value	0.00175202 (rank : 412)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1734	Shared Neighborhood Hits	715
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

M3K2_MOUSE
NC score	0.529034 (rank : 290)	θ value	0.000121331 (rank : 289)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	562
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

IKKE_HUMAN
NC score	0.528990 (rank : 291)	θ value	0.000461057 (rank : 347)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	557
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
NC score	0.528856 (rank : 292)	θ value	0.00665767 (rank : 474)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	555
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

GUC2D_HUMAN
NC score	0.528606 (rank : 293)	θ value	1.09739e-05 (rank : 196)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	514
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

E2AK3_MOUSE
NC score	0.528583 (rank : 294)	θ value	0.00298849 (rank : 435)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	562
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ULK3_MOUSE
NC score	0.528440 (rank : 295)	θ value	9.29e-05 (rank : 284)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	567
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

TAOK1_MOUSE
NC score	0.528386 (rank : 296)	θ value	0.00665767 (rank : 480)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1720	Shared Neighborhood Hits	713
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK3_HUMAN
NC score	0.528159 (rank : 297)	θ value	0.163984 (rank : 677)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1494	Shared Neighborhood Hits	680
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

ANPRA_HUMAN
NC score	0.528089 (rank : 298)	θ value	0.813845 (rank : 771)
Query Neighborhood Hits	1103	Target Neighborhood Hits	612	Shared Neighborhood Hits	433
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

PAK1_HUMAN
NC score	0.527965 (rank : 299)	θ value	1.43324e-05 (rank : 206)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	570
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
NC score	0.527921 (rank : 300)	θ value	1.43324e-05 (rank : 207)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	573
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

NEK3_HUMAN
NC score	0.527494 (rank : 301)	θ value	θ > 10 (rank : 1520)
Query Neighborhood Hits	1103	Target Neighborhood Hits	865	Shared Neighborhood Hits	571
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

AL2S2_HUMAN
NC score	0.527266 (rank : 302)	θ value	3.19293e-05 (rank : 237)
Query Neighborhood Hits	1103	Target Neighborhood Hits	727	Shared Neighborhood Hits	531
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

M3K15_HUMAN
NC score	0.525739 (rank : 303)	θ value	1.38821 (rank : 830)
Query Neighborhood Hits	1103	Target Neighborhood Hits	914	Shared Neighborhood Hits	575
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

PAK3_MOUSE
NC score	0.525685 (rank : 304)	θ value	4.1701e-05 (rank : 252)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	572
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.525409 (rank : 305)	θ value	4.1701e-05 (rank : 251)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	574
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

ANPRB_HUMAN
NC score	0.525313 (rank : 306)	θ value	0.0148317 (rank : 510)
Query Neighborhood Hits	1103	Target Neighborhood Hits	646	Shared Neighborhood Hits	441
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

AL2S2_MOUSE
NC score	0.524859 (rank : 307)	θ value	5.44631e-05 (rank : 254)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	520
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

ANPRA_MOUSE
NC score	0.524182 (rank : 308)	θ value	0.813845 (rank : 772)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	422
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

MYLK2_HUMAN
NC score	0.524152 (rank : 309)	θ value	0.0563607 (rank : 611)
Query Neighborhood Hits	1103	Target Neighborhood Hits	920	Shared Neighborhood Hits	563
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PAK4_HUMAN
NC score	0.524035 (rank : 310)	θ value	0.00020696 (rank : 316)
Query Neighborhood Hits	1103	Target Neighborhood Hits	924	Shared Neighborhood Hits	577
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
NC score	0.523684 (rank : 311)	θ value	7.1131e-05 (rank : 272)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1098	Shared Neighborhood Hits	591
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NEK3_MOUSE
NC score	0.523355 (rank : 312)	θ value	θ > 10 (rank : 1521)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	565
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

E2AK1_HUMAN
NC score	0.522888 (rank : 313)	θ value	0.21417 (rank : 683)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	555
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

NEK2_MOUSE
NC score	0.522881 (rank : 314)	θ value	0.0252991 (rank : 561)
Query Neighborhood Hits	1103	Target Neighborhood Hits	876	Shared Neighborhood Hits	576
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

IRAK2_HUMAN
NC score	0.522871 (rank : 315)	θ value	θ > 10 (rank : 1407)
Query Neighborhood Hits	1103	Target Neighborhood Hits	714	Shared Neighborhood Hits	502
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

WNK1_HUMAN
NC score	0.521946 (rank : 316)	θ value	0.00869519 (rank : 490)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1158	Shared Neighborhood Hits	574
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

SLK_HUMAN
NC score	0.521846 (rank : 317)	θ value	0.0961366 (rank : 647)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1775	Shared Neighborhood Hits	708
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
NC score	0.521221 (rank : 318)	θ value	0.279714 (rank : 708)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1798	Shared Neighborhood Hits	717
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

STK36_MOUSE
NC score	0.521160 (rank : 319)	θ value	0.47712 (rank : 751)
Query Neighborhood Hits	1103	Target Neighborhood Hits	877	Shared Neighborhood Hits	571
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

WNK1_MOUSE
NC score	0.521008 (rank : 320)	θ value	0.00869519 (rank : 491)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1179	Shared Neighborhood Hits	577
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

NEK9_HUMAN
NC score	0.520283 (rank : 321)	θ value	1.81305 (rank : 868)
Query Neighborhood Hits	1103	Target Neighborhood Hits	900	Shared Neighborhood Hits	572
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NUAK2_HUMAN
NC score	0.520281 (rank : 322)	θ value	7.1131e-05 (rank : 271)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	571
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

TBK1_HUMAN
NC score	0.520267 (rank : 323)	θ value	0.00102713 (rank : 370)
Query Neighborhood Hits	1103	Target Neighborhood Hits	861	Shared Neighborhood Hits	566
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

STK10_HUMAN
NC score	0.520078 (rank : 324)	θ value	0.0563607 (rank : 614)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1921	Shared Neighborhood Hits	722
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

ACVL1_MOUSE
NC score	0.519638 (rank : 325)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	1103	Target Neighborhood Hits	739	Shared Neighborhood Hits	531
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

STK33_HUMAN
NC score	0.519608 (rank : 326)	θ value	0.62314 (rank : 768)
Query Neighborhood Hits	1103	Target Neighborhood Hits	879	Shared Neighborhood Hits	572
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

NUAK1_HUMAN
NC score	0.519394 (rank : 327)	θ value	0.000270298 (rank : 328)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	565
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
NC score	0.519013 (rank : 328)	θ value	0.00020696 (rank : 315)
Query Neighborhood Hits	1103	Target Neighborhood Hits	881	Shared Neighborhood Hits	572
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

TBK1_MOUSE
NC score	0.518977 (rank : 329)	θ value	0.00134147 (rank : 393)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	573
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

NEK9_MOUSE
NC score	0.518742 (rank : 330)	θ value	1.81305 (rank : 869)
Query Neighborhood Hits	1103	Target Neighborhood Hits	890	Shared Neighborhood Hits	572
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

STK36_HUMAN
NC score	0.518252 (rank : 331)	θ value	0.0563607 (rank : 616)
Query Neighborhood Hits	1103	Target Neighborhood Hits	896	Shared Neighborhood Hits	571
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK6_HUMAN
NC score	0.518162 (rank : 332)	θ value	0.000786445 (rank : 361)
Query Neighborhood Hits	1103	Target Neighborhood Hits	916	Shared Neighborhood Hits	578
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

M3K6_HUMAN
NC score	0.517555 (rank : 333)	θ value	θ > 10 (rank : 1464)
Query Neighborhood Hits	1103	Target Neighborhood Hits	889	Shared Neighborhood Hits	568
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K4_HUMAN
NC score	0.517533 (rank : 334)	θ value	0.0330416 (rank : 578)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	577
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K5_MOUSE
NC score	0.517227 (rank : 335)	θ value	θ > 10 (rank : 1463)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	565
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.517133 (rank : 336)	θ value	θ > 10 (rank : 1462)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	570
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MP2K2_HUMAN
NC score	0.517077 (rank : 337)	θ value	θ > 10 (rank : 1485)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	561
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

M3K4_MOUSE
NC score	0.516760 (rank : 338)	θ value	0.0252991 (rank : 559)
Query Neighborhood Hits	1103	Target Neighborhood Hits	924	Shared Neighborhood Hits	580
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

NEK8_HUMAN
NC score	0.516289 (rank : 339)	θ value	0.365318 (rank : 727)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	564
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NUAK2_MOUSE
NC score	0.516243 (rank : 340)	θ value	3.19293e-05 (rank : 243)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	570
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

MP2K7_HUMAN
NC score	0.515717 (rank : 341)	θ value	3.0926 (rank : 925)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	563
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

NEK8_MOUSE
NC score	0.515656 (rank : 342)	θ value	0.365318 (rank : 728)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	565
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

AURKC_HUMAN
NC score	0.515273 (rank : 343)	θ value	0.00509761 (rank : 462)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	567
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

ANPRB_MOUSE
NC score	0.514642 (rank : 344)	θ value	0.0113563 (rank : 492)
Query Neighborhood Hits	1103	Target Neighborhood Hits	607	Shared Neighborhood Hits	428
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

STK11_HUMAN
NC score	0.514629 (rank : 345)	θ value	0.000461057 (rank : 351)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	559
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

NIM1_HUMAN
NC score	0.514496 (rank : 346)	θ value	0.00175202 (rank : 406)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	567
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

MP2K2_MOUSE
NC score	0.514414 (rank : 347)	θ value	θ > 10 (rank : 1486)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	560
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

BMR1A_HUMAN
NC score	0.514344 (rank : 348)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	1103	Target Neighborhood Hits	759	Shared Neighborhood Hits	542
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

M4K4_MOUSE
NC score	0.514035 (rank : 349)	θ value	1.38821 (rank : 832)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1560	Shared Neighborhood Hits	664
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

PLK3_MOUSE
NC score	0.513295 (rank : 350)	θ value	1.43324e-05 (rank : 208)
Query Neighborhood Hits	1103	Target Neighborhood Hits	863	Shared Neighborhood Hits	567
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

WNK3_HUMAN
NC score	0.513271 (rank : 351)	θ value	0.125558 (rank : 660)
Query Neighborhood Hits	1103	Target Neighborhood Hits	948	Shared Neighborhood Hits	552
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

BMR1A_MOUSE
NC score	0.513234 (rank : 352)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	540
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

STK6_MOUSE
NC score	0.512570 (rank : 353)	θ value	0.00134147 (rank : 392)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	576
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

PLK4_MOUSE
NC score	0.512566 (rank : 354)	θ value	0.0431538 (rank : 600)
Query Neighborhood Hits	1103	Target Neighborhood Hits	879	Shared Neighborhood Hits	571
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

M4K1_HUMAN
NC score	0.512432 (rank : 355)	θ value	8.99809 (rank : 1079)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	571
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

PLK3_HUMAN
NC score	0.512374 (rank : 356)	θ value	1.87187e-05 (rank : 221)
Query Neighborhood Hits	1103	Target Neighborhood Hits	865	Shared Neighborhood Hits	568
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

AURKC_MOUSE
NC score	0.512072 (rank : 357)	θ value	0.0736092 (rank : 622)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	565
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

MINK1_MOUSE
NC score	0.511836 (rank : 358)	θ value	1.81305 (rank : 861)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1451	Shared Neighborhood Hits	660
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PLK4_HUMAN
NC score	0.511370 (rank : 359)	θ value	0.0961366 (rank : 644)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	569
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

E2AK1_MOUSE
NC score	0.511369 (rank : 360)	θ value	1.38821 (rank : 821)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	550
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MINK1_HUMAN
NC score	0.511344 (rank : 361)	θ value	1.81305 (rank : 860)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1477	Shared Neighborhood Hits	656
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

TNIK_HUMAN
NC score	0.511294 (rank : 362)	θ value	1.06291 (rank : 807)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1570	Shared Neighborhood Hits	667
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

NIM1_MOUSE
NC score	0.511261 (rank : 363)	θ value	0.000158464 (rank : 300)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	565
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

STK10_MOUSE
NC score	0.511252 (rank : 364)	θ value	0.0563607 (rank : 615)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2132	Shared Neighborhood Hits	754
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MP2K1_MOUSE
NC score	0.511149 (rank : 365)	θ value	θ > 10 (rank : 1484)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	558
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_HUMAN
NC score	0.511133 (rank : 366)	θ value	θ > 10 (rank : 1483)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	558
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

PLK2_MOUSE
NC score	0.511039 (rank : 367)	θ value	0.125558 (rank : 658)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	566
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

M4K1_MOUSE
NC score	0.511037 (rank : 368)	θ value	θ > 10 (rank : 1465)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	568
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MARK4_MOUSE
NC score	0.510961 (rank : 369)	θ value	0.0148317 (rank : 523)
Query Neighborhood Hits	1103	Target Neighborhood Hits	898	Shared Neighborhood Hits	577
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

WNK4_MOUSE
NC score	0.510955 (rank : 370)	θ value	0.0252991 (rank : 571)
Query Neighborhood Hits	1103	Target Neighborhood Hits	961	Shared Neighborhood Hits	544
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MARK4_HUMAN
NC score	0.510932 (rank : 371)	θ value	0.0148317 (rank : 522)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	577
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

PLK2_HUMAN
NC score	0.510863 (rank : 372)	θ value	0.163984 (rank : 675)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	566
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

HUNK_HUMAN
NC score	0.510661 (rank : 373)	θ value	0.00665767 (rank : 473)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	573
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

KS6A3_MOUSE
NC score	0.510468 (rank : 374)	θ value	2.21117e-06 (rank : 160)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	572
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.510465 (rank : 375)	θ value	2.21117e-06 (rank : 159)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	572
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

WNK2_HUMAN
NC score	0.510268 (rank : 376)	θ value	0.47712 (rank : 753)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1407	Shared Neighborhood Hits	588
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

MARK1_HUMAN
NC score	0.510246 (rank : 377)	θ value	0.0961366 (rank : 641)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	576
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

HUNK_MOUSE
NC score	0.510072 (rank : 378)	θ value	0.0113563 (rank : 503)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	569
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

MARK3_MOUSE
NC score	0.509760 (rank : 379)	θ value	0.21417 (rank : 688)
Query Neighborhood Hits	1103	Target Neighborhood Hits	919	Shared Neighborhood Hits	579
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KS6A2_HUMAN
NC score	0.509747 (rank : 380)	θ value	9.92553e-07 (rank : 135)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	569
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MARK2_HUMAN
NC score	0.509719 (rank : 381)	θ value	0.163984 (rank : 672)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1056	Shared Neighborhood Hits	608
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

BMR1B_MOUSE
NC score	0.509429 (rank : 382)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	538
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

KS6A1_HUMAN
NC score	0.509145 (rank : 383)	θ value	0.000121331 (rank : 288)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	572
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MARK1_MOUSE
NC score	0.509098 (rank : 384)	θ value	0.21417 (rank : 687)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	575
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

PLK1_HUMAN
NC score	0.509029 (rank : 385)	θ value	0.125558 (rank : 657)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	567
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KS6A2_MOUSE
NC score	0.508909 (rank : 386)	θ value	7.59969e-07 (rank : 132)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	571
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

WNK4_HUMAN
NC score	0.508476 (rank : 387)	θ value	0.0736092 (rank : 629)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1043	Shared Neighborhood Hits	558
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MP2K4_HUMAN
NC score	0.508210 (rank : 388)	θ value	θ > 10 (rank : 1489)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	564
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MARK3_HUMAN
NC score	0.508183 (rank : 389)	θ value	0.47712 (rank : 745)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	575
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MP2K4_MOUSE
NC score	0.508137 (rank : 390)	θ value	θ > 10 (rank : 1490)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	564
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K6_MOUSE
NC score	0.507976 (rank : 391)	θ value	5.27518 (rank : 996)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	559
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

BMR1B_HUMAN
NC score	0.507962 (rank : 392)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	1103	Target Neighborhood Hits	760	Shared Neighborhood Hits	537
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

MP2K6_HUMAN
NC score	0.507960 (rank : 393)	θ value	5.27518 (rank : 995)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	558
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

ACVL1_HUMAN
NC score	0.507238 (rank : 394)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	1103	Target Neighborhood Hits	716	Shared Neighborhood Hits	519
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

NRK_HUMAN
NC score	0.506879 (rank : 395)	θ value	5.27518 (rank : 1005)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	576
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

DAPK3_MOUSE
NC score	0.506680 (rank : 396)	θ value	0.0431538 (rank : 590)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	557
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

AAPK1_HUMAN
NC score	0.506537 (rank : 397)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

M3K8_HUMAN
NC score	0.506501 (rank : 398)	θ value	0.0736092 (rank : 627)
Query Neighborhood Hits	1103	Target Neighborhood Hits	807	Shared Neighborhood Hits	548
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

AAPK1_MOUSE
NC score	0.505971 (rank : 399)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	563
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AURKB_HUMAN
NC score	0.505959 (rank : 400)	θ value	0.163984 (rank : 663)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	565
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

SN1L2_HUMAN
NC score	0.505846 (rank : 401)	θ value	8.99809 (rank : 1090)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	584
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

DAPK3_HUMAN
NC score	0.505835 (rank : 402)	θ value	0.0961366 (rank : 636)
Query Neighborhood Hits	1103	Target Neighborhood Hits	945	Shared Neighborhood Hits	579
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

MARK2_MOUSE
NC score	0.505584 (rank : 403)	θ value	0.365318 (rank : 723)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1018	Shared Neighborhood Hits	605
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MAK_MOUSE
NC score	0.505561 (rank : 404)	θ value	0.00035302 (rank : 337)
Query Neighborhood Hits	1103	Target Neighborhood Hits	873	Shared Neighborhood Hits	567
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

NRK_MOUSE
NC score	0.505347 (rank : 405)	θ value	3.0926 (rank : 930)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	570
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

M4K3_HUMAN
NC score	0.505197 (rank : 406)	θ value	θ > 10 (rank : 1468)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	572
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

ST17B_MOUSE
NC score	0.504888 (rank : 407)	θ value	0.163984 (rank : 676)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	560
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

SN1L1_MOUSE
NC score	0.504882 (rank : 408)	θ value	5.27518 (rank : 1011)
Query Neighborhood Hits	1103	Target Neighborhood Hits	895	Shared Neighborhood Hits	575
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

M3K8_MOUSE
NC score	0.504502 (rank : 409)	θ value	0.0193708 (rank : 537)
Query Neighborhood Hits	1103	Target Neighborhood Hits	815	Shared Neighborhood Hits	550
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

TSSK4_MOUSE
NC score	0.504350 (rank : 410)	θ value	θ > 10 (rank : 1767)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	561
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

ICK_HUMAN
NC score	0.504270 (rank : 411)	θ value	0.00134147 (rank : 381)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	562
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
NC score	0.504204 (rank : 412)	θ value	0.00102713 (rank : 365)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	562
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

AURKB_MOUSE
NC score	0.503974 (rank : 413)	θ value	0.00869519 (rank : 481)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	566
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

CDK6_MOUSE
NC score	0.503573 (rank : 414)	θ value	0.00035302 (rank : 333)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	563
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

SN1L2_MOUSE
NC score	0.503322 (rank : 415)	θ value	θ > 10 (rank : 1679)
Query Neighborhood Hits	1103	Target Neighborhood Hits	944	Shared Neighborhood Hits	574
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

ACVR1_MOUSE
NC score	0.503290 (rank : 416)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	1103	Target Neighborhood Hits	768	Shared Neighborhood Hits	549
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

MP2K3_MOUSE
NC score	0.502916 (rank : 417)	θ value	θ > 10 (rank : 1488)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	555
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

M4K4_HUMAN
NC score	0.502573 (rank : 418)	θ value	1.38821 (rank : 831)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1589	Shared Neighborhood Hits	666
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

KS6A6_HUMAN
NC score	0.502450 (rank : 419)	θ value	5.44631e-05 (rank : 260)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	569
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

MAK_HUMAN
NC score	0.502360 (rank : 420)	θ value	0.00134147 (rank : 386)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	560
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

DAPK2_MOUSE
NC score	0.502126 (rank : 421)	θ value	0.0961366 (rank : 635)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	560
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

CDK6_HUMAN
NC score	0.501845 (rank : 422)	θ value	0.00035302 (rank : 332)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	563
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MP2K3_HUMAN
NC score	0.501604 (rank : 423)	θ value	θ > 10 (rank : 1487)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	555
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

AAPK2_HUMAN
NC score	0.500967 (rank : 424)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	562
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

SN1L1_HUMAN
NC score	0.500832 (rank : 425)	θ value	2.36792 (rank : 900)
Query Neighborhood Hits	1103	Target Neighborhood Hits	911	Shared Neighborhood Hits	576
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

PLK1_MOUSE
NC score	0.500463 (rank : 426)	θ value	0.0736092 (rank : 628)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	566
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

M4K2_MOUSE
NC score	0.499830 (rank : 427)	θ value	θ > 10 (rank : 1467)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	565
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

TSSK6_HUMAN
NC score	0.499685 (rank : 428)	θ value	0.00175202 (rank : 413)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	558
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ACVR1_HUMAN
NC score	0.499525 (rank : 429)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	1103	Target Neighborhood Hits	760	Shared Neighborhood Hits	544
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

K0999_MOUSE
NC score	0.499471 (rank : 430)	θ value	2.36792 (rank : 890)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	574
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

TSSK6_MOUSE
NC score	0.499326 (rank : 431)	θ value	0.00390308 (rank : 459)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	557
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

K0999_HUMAN
NC score	0.499238 (rank : 432)	θ value	2.36792 (rank : 889)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	569
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

STK35_HUMAN
NC score	0.498425 (rank : 433)	θ value	θ > 10 (rank : 1717)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	553
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

M4K2_HUMAN
NC score	0.498006 (rank : 434)	θ value	θ > 10 (rank : 1466)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	566
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

TSSK4_HUMAN
NC score	0.497495 (rank : 435)	θ value	θ > 10 (rank : 1766)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	561
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

KPCD2_HUMAN
NC score	0.496971 (rank : 436)	θ value	1.87187e-05 (rank : 219)
Query Neighborhood Hits	1103	Target Neighborhood Hits	910	Shared Neighborhood Hits	562
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

CDK4_MOUSE
NC score	0.496690 (rank : 437)	θ value	0.00020696 (rank : 308)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	564
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

M3K14_HUMAN
NC score	0.496609 (rank : 438)	θ value	0.0961366 (rank : 639)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	561
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

CHK1_HUMAN
NC score	0.496453 (rank : 439)	θ value	θ > 10 (rank : 1246)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	561
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MELK_HUMAN
NC score	0.496167 (rank : 440)	θ value	0.0193708 (rank : 542)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	567
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

KPSH2_HUMAN
NC score	0.495970 (rank : 441)	θ value	1.69304e-06 (rank : 148)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	554
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

CHK1_MOUSE
NC score	0.495952 (rank : 442)	θ value	θ > 10 (rank : 1247)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	562
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

DAPK2_HUMAN
NC score	0.495353 (rank : 443)	θ value	0.125558 (rank : 653)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	557
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

BRSK2_HUMAN
NC score	0.495216 (rank : 444)	θ value	θ > 10 (rank : 1186)
Query Neighborhood Hits	1103	Target Neighborhood Hits	897	Shared Neighborhood Hits	570
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MELK_MOUSE
NC score	0.494658 (rank : 445)	θ value	0.0252991 (rank : 560)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	564
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

ST17B_HUMAN
NC score	0.494227 (rank : 446)	θ value	0.813845 (rank : 780)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	556
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

PRKY_HUMAN
NC score	0.493580 (rank : 447)	θ value	0.813845 (rank : 775)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	566
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

M4K5_HUMAN
NC score	0.493481 (rank : 448)	θ value	θ > 10 (rank : 1469)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	566
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
NC score	0.493396 (rank : 449)	θ value	θ > 10 (rank : 1470)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	563
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

TSSK1_MOUSE
NC score	0.492883 (rank : 450)	θ value	θ > 10 (rank : 1761)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	559
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CDK4_HUMAN
NC score	0.492818 (rank : 451)	θ value	0.000786445 (rank : 358)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	562
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

TGFR1_MOUSE
NC score	0.492765 (rank : 452)	θ value	1.38821 (rank : 840)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	545
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR1_HUMAN
NC score	0.492602 (rank : 453)	θ value	1.38821 (rank : 839)
Query Neighborhood Hits	1103	Target Neighborhood Hits	755	Shared Neighborhood Hits	545
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

CDC2_HUMAN
NC score	0.491723 (rank : 454)	θ value	θ > 10 (rank : 1210)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	563
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

ERN1_HUMAN
NC score	0.491664 (rank : 455)	θ value	8.99809 (rank : 1070)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	550
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

BRSK1_HUMAN
NC score	0.491643 (rank : 456)	θ value	θ > 10 (rank : 1185)
Query Neighborhood Hits	1103	Target Neighborhood Hits	942	Shared Neighborhood Hits	573
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

KS6A1_MOUSE
NC score	0.491284 (rank : 457)	θ value	0.0431538 (rank : 595)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	570
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PDPK1_MOUSE
NC score	0.490632 (rank : 458)	θ value	0.0252991 (rank : 564)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	561
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

KPCD1_HUMAN
NC score	0.490564 (rank : 459)	θ value	0.000602161 (rank : 355)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	562
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

TSSK2_HUMAN
NC score	0.490206 (rank : 460)	θ value	θ > 10 (rank : 1762)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	558
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

PDPK1_HUMAN
NC score	0.490183 (rank : 461)	θ value	0.0330416 (rank : 582)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	561
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

CD2L7_HUMAN
NC score	0.489838 (rank : 462)	θ value	8.99809 (rank : 1064)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1275	Shared Neighborhood Hits	624
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDC2_MOUSE
NC score	0.489635 (rank : 463)	θ value	θ > 10 (rank : 1211)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	562
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CD2L5_MOUSE
NC score	0.489600 (rank : 464)	θ value	θ > 10 (rank : 1209)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1011	Shared Neighborhood Hits	588
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

KPCD1_MOUSE
NC score	0.489395 (rank : 465)	θ value	0.00134147 (rank : 382)
Query Neighborhood Hits	1103	Target Neighborhood Hits	891	Shared Neighborhood Hits	563
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

BMPR2_HUMAN
NC score	0.489306 (rank : 466)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	1103	Target Neighborhood Hits	736	Shared Neighborhood Hits	525
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

KCC1G_MOUSE
NC score	0.489035 (rank : 467)	θ value	0.00228821 (rank : 422)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	559
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

CD2L5_HUMAN
NC score	0.488805 (rank : 468)	θ value	θ > 10 (rank : 1208)
Query Neighborhood Hits	1103	Target Neighborhood Hits	987	Shared Neighborhood Hits	578
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

KPCT_HUMAN
NC score	0.488723 (rank : 469)	θ value	0.163984 (rank : 671)
Query Neighborhood Hits	1103	Target Neighborhood Hits	897	Shared Neighborhood Hits	564
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PDK1L_MOUSE
NC score	0.488651 (rank : 470)	θ value	2.36792 (rank : 895)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	551
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KCC1G_HUMAN
NC score	0.488645 (rank : 471)	θ value	0.00298849 (rank : 439)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	560
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

GUC2G_MOUSE
NC score	0.488488 (rank : 472)	θ value	θ > 10 (rank : 1387)
Query Neighborhood Hits	1103	Target Neighborhood Hits	644	Shared Neighborhood Hits	451
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

KPCD3_HUMAN
NC score	0.488241 (rank : 473)	θ value	0.00134147 (rank : 383)
Query Neighborhood Hits	1103	Target Neighborhood Hits	895	Shared Neighborhood Hits	561
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

CDK3_HUMAN
NC score	0.488100 (rank : 474)	θ value	θ > 10 (rank : 1216)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	560
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

PKN1_HUMAN
NC score	0.487978 (rank : 475)	θ value	θ > 10 (rank : 1573)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	570
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

KPCD3_MOUSE
NC score	0.487795 (rank : 476)	θ value	0.00134147 (rank : 384)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	560
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCD_HUMAN
NC score	0.487658 (rank : 477)	θ value	0.163984 (rank : 670)
Query Neighborhood Hits	1103	Target Neighborhood Hits	900	Shared Neighborhood Hits	562
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

PDK1L_HUMAN
NC score	0.487536 (rank : 478)	θ value	4.03905 (rank : 965)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	550
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KPSH1_MOUSE
NC score	0.487419 (rank : 479)	θ value	3.77169e-06 (rank : 172)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	558
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

PKN1_MOUSE
NC score	0.487351 (rank : 480)	θ value	θ > 10 (rank : 1574)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	566
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

ERN1_MOUSE
NC score	0.487020 (rank : 481)	θ value	θ > 10 (rank : 1336)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	548
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KPSH1_HUMAN
NC score	0.486448 (rank : 482)	θ value	3.77169e-06 (rank : 171)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	557
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC1A_HUMAN
NC score	0.486428 (rank : 483)	θ value	0.0148317 (rank : 516)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	564
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

BMPR2_MOUSE
NC score	0.486298 (rank : 484)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	1103	Target Neighborhood Hits	738	Shared Neighborhood Hits	524
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

KPCT_MOUSE
NC score	0.486217 (rank : 485)	θ value	0.365318 (rank : 721)
Query Neighborhood Hits	1103	Target Neighborhood Hits	895	Shared Neighborhood Hits	562
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KCC1A_MOUSE
NC score	0.486087 (rank : 486)	θ value	0.0148317 (rank : 517)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	564
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KKCC2_MOUSE
NC score	0.486083 (rank : 487)	θ value	θ > 10 (rank : 1432)
Query Neighborhood Hits	1103	Target Neighborhood Hits	855	Shared Neighborhood Hits	563
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.486001 (rank : 488)	θ value	θ > 10 (rank : 1431)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	563
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

CDKL3_HUMAN
NC score	0.485267 (rank : 489)	θ value	0.62314 (rank : 756)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	564
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

SBK1_MOUSE
NC score	0.484624 (rank : 490)	θ value	0.813845 (rank : 777)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	544
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

KCC1B_MOUSE
NC score	0.484546 (rank : 491)	θ value	0.163984 (rank : 669)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

E2AK4_HUMAN
NC score	0.484183 (rank : 492)	θ value	θ > 10 (rank : 1328)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1012	Shared Neighborhood Hits	598
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

PKN2_HUMAN
NC score	0.484080 (rank : 493)	θ value	θ > 10 (rank : 1575)
Query Neighborhood Hits	1103	Target Neighborhood Hits	892	Shared Neighborhood Hits	571
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

KCC1B_HUMAN
NC score	0.483810 (rank : 494)	θ value	0.279714 (rank : 702)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	562
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

NLK_MOUSE
NC score	0.483762 (rank : 495)	θ value	3.0926 (rank : 927)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	561
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.483685 (rank : 496)	θ value	3.0926 (rank : 926)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	561
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

PKN2_MOUSE
NC score	0.483562 (rank : 497)	θ value	θ > 10 (rank : 1576)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	567
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

KS6B1_MOUSE
NC score	0.483092 (rank : 498)	θ value	2.44474e-05 (rank : 232)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	565
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.483039 (rank : 499)	θ value	2.44474e-05 (rank : 231)
Query Neighborhood Hits	1103	Target Neighborhood Hits	850	Shared Neighborhood Hits	566
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

CDK3_MOUSE
NC score	0.483010 (rank : 500)	θ value	θ > 10 (rank : 1217)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	558
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK2_HUMAN
NC score	0.482831 (rank : 501)	θ value	θ > 10 (rank : 1214)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	560
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDKL3_MOUSE
NC score	0.482696 (rank : 502)	θ value	0.21417 (rank : 681)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	562
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KGP2_HUMAN
NC score	0.482356 (rank : 503)	θ value	6.43352e-06 (rank : 183)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	597
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

TGFR2_HUMAN
NC score	0.482311 (rank : 504)	θ value	θ > 10 (rank : 1734)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	538
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

MK03_MOUSE
NC score	0.482227 (rank : 505)	θ value	0.00228821 (rank : 424)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	559
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK03_HUMAN
NC score	0.482038 (rank : 506)	θ value	0.00869519 (rank : 486)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	558
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

CDK2_MOUSE
NC score	0.482012 (rank : 507)	θ value	θ > 10 (rank : 1215)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	556
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

KGP2_MOUSE
NC score	0.482008 (rank : 508)	θ value	4.92598e-06 (rank : 179)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1029	Shared Neighborhood Hits	597
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PRKX_MOUSE
NC score	0.481972 (rank : 509)	θ value	0.0193708 (rank : 549)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	565
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

AL2S7_HUMAN
NC score	0.481828 (rank : 510)	θ value	5.27518 (rank : 980)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	557
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

KPCD_MOUSE
NC score	0.481695 (rank : 511)	θ value	1.06291 (rank : 793)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	562
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

TGFR2_MOUSE
NC score	0.481605 (rank : 512)	θ value	θ > 10 (rank : 1735)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	539
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

DCAK1_HUMAN
NC score	0.481398 (rank : 513)	θ value	0.0252991 (rank : 554)
Query Neighborhood Hits	1103	Target Neighborhood Hits	877	Shared Neighborhood Hits	568
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

M3K14_MOUSE
NC score	0.481301 (rank : 514)	θ value	0.0431538 (rank : 596)
Query Neighborhood Hits	1103	Target Neighborhood Hits	889	Shared Neighborhood Hits	548
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

KCC1D_MOUSE
NC score	0.481260 (rank : 515)	θ value	0.0148317 (rank : 519)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	561
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.481232 (rank : 516)	θ value	0.0148317 (rank : 518)
Query Neighborhood Hits	1103	Target Neighborhood Hits	846	Shared Neighborhood Hits	561
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

ST17A_HUMAN
NC score	0.481212 (rank : 517)	θ value	θ > 10 (rank : 1698)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	556
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

KGP1B_MOUSE
NC score	0.480971 (rank : 518)	θ value	1.87187e-05 (rank : 218)
Query Neighborhood Hits	1103	Target Neighborhood Hits	922	Shared Neighborhood Hits	576
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.480949 (rank : 519)	θ value	1.87187e-05 (rank : 216)
Query Neighborhood Hits	1103	Target Neighborhood Hits	901	Shared Neighborhood Hits	572
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
NC score	0.480933 (rank : 520)	θ value	1.87187e-05 (rank : 217)
Query Neighborhood Hits	1103	Target Neighborhood Hits	921	Shared Neighborhood Hits	576
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KS6B2_HUMAN
NC score	0.480853 (rank : 521)	θ value	4.92598e-06 (rank : 180)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	568
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

DCAK1_MOUSE
NC score	0.480850 (rank : 522)	θ value	0.0252991 (rank : 555)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	563
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

ACV1B_HUMAN
NC score	0.480552 (rank : 523)	θ value	5.27518 (rank : 979)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	543
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

MK01_MOUSE
NC score	0.480471 (rank : 524)	θ value	0.0961366 (rank : 643)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	555
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

ST32A_MOUSE
NC score	0.480175 (rank : 525)	θ value	3.0926 (rank : 941)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	557
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

MK01_HUMAN
NC score	0.480149 (rank : 526)	θ value	0.0961366 (rank : 642)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	555
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

PRKX_HUMAN
NC score	0.480121 (rank : 527)	θ value	0.0961366 (rank : 645)
Query Neighborhood Hits	1103	Target Neighborhood Hits	847	Shared Neighborhood Hits	566
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

ACV1B_MOUSE
NC score	0.479973 (rank : 528)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	542
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

CD2L1_HUMAN
NC score	0.479928 (rank : 529)	θ value	0.00298849 (rank : 434)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1467	Shared Neighborhood Hits	669
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CDKL2_HUMAN
NC score	0.479898 (rank : 530)	θ value	θ > 10 (rank : 1226)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	561
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
NC score	0.479767 (rank : 531)	θ value	θ > 10 (rank : 1227)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	562
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

PKN3_MOUSE
NC score	0.479678 (rank : 532)	θ value	θ > 10 (rank : 1578)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1009	Shared Neighborhood Hits	585
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

TSSK2_MOUSE
NC score	0.479603 (rank : 533)	θ value	θ > 10 (rank : 1763)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	550
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

CD2L2_HUMAN
NC score	0.479322 (rank : 534)	θ value	0.0113563 (rank : 499)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1439	Shared Neighborhood Hits	669
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CDK10_HUMAN
NC score	0.479145 (rank : 535)	θ value	0.0961366 (rank : 632)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	559
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CD2L1_MOUSE
NC score	0.479057 (rank : 536)	θ value	0.163984 (rank : 666)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1463	Shared Neighborhood Hits	669
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

SBK1_HUMAN
NC score	0.478959 (rank : 537)	θ value	2.36792 (rank : 899)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	545
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MK12_HUMAN
NC score	0.478781 (rank : 538)	θ value	0.00390308 (rank : 452)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	557
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

DCAK3_HUMAN
NC score	0.478203 (rank : 539)	θ value	0.47712 (rank : 739)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	575
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

SNRK_MOUSE
NC score	0.478175 (rank : 540)	θ value	θ > 10 (rank : 1681)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	552
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

CDKL4_MOUSE
NC score	0.478151 (rank : 541)	θ value	θ > 10 (rank : 1229)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	559
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

DCAK3_MOUSE
NC score	0.478093 (rank : 542)	θ value	θ > 10 (rank : 1305)
Query Neighborhood Hits	1103	Target Neighborhood Hits	922	Shared Neighborhood Hits	589
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KKCC1_MOUSE
NC score	0.477831 (rank : 543)	θ value	θ > 10 (rank : 1430)
Query Neighborhood Hits	1103	Target Neighborhood Hits	866	Shared Neighborhood Hits	562
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_HUMAN
NC score	0.477655 (rank : 544)	θ value	θ > 10 (rank : 1429)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	563
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PFTK1_MOUSE
NC score	0.476565 (rank : 545)	θ value	6.88961 (rank : 1044)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	557
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KS6B2_MOUSE
NC score	0.476564 (rank : 546)	θ value	6.43352e-06 (rank : 184)
Query Neighborhood Hits	1103	Target Neighborhood Hits	871	Shared Neighborhood Hits	569
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

SNRK_HUMAN
NC score	0.476358 (rank : 547)	θ value	θ > 10 (rank : 1680)
Query Neighborhood Hits	1103	Target Neighborhood Hits	855	Shared Neighborhood Hits	558
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MK12_MOUSE
NC score	0.475960 (rank : 548)	θ value	0.00390308 (rank : 453)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	558
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

CDK9_HUMAN
NC score	0.475868 (rank : 549)	θ value	θ > 10 (rank : 1222)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	557
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

TSSK1_HUMAN
NC score	0.475357 (rank : 550)	θ value	θ > 10 (rank : 1760)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	552
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

PFTK1_HUMAN
NC score	0.475352 (rank : 551)	θ value	8.99809 (rank : 1086)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	556
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDK9_MOUSE
NC score	0.475185 (rank : 552)	θ value	θ > 10 (rank : 1223)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	557
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

MASTL_MOUSE
NC score	0.475105 (rank : 553)	θ value	0.365318 (rank : 724)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	564
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MK14_HUMAN
NC score	0.475033 (rank : 554)	θ value	0.365318 (rank : 725)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	561
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

KPCA_MOUSE
NC score	0.474896 (rank : 555)	θ value	0.0431538 (rank : 594)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1067	Shared Neighborhood Hits	559
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

CDK5_MOUSE
NC score	0.474812 (rank : 556)	θ value	θ > 10 (rank : 1219)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	557
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK7_MOUSE
NC score	0.474617 (rank : 557)	θ value	θ > 10 (rank : 1221)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	560
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK5_HUMAN
NC score	0.474481 (rank : 558)	θ value	θ > 10 (rank : 1218)
Query Neighborhood Hits	1103	Target Neighborhood Hits	826	Shared Neighborhood Hits	557
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

ST32A_HUMAN
NC score	0.474431 (rank : 559)	θ value	θ > 10 (rank : 1699)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	557
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

MK07_MOUSE
NC score	0.474006 (rank : 560)	θ value	1.81305 (rank : 862)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1054	Shared Neighborhood Hits	581
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

E2AK4_MOUSE
NC score	0.473984 (rank : 561)	θ value	θ > 10 (rank : 1329)
Query Neighborhood Hits	1103	Target Neighborhood Hits	984	Shared Neighborhood Hits	586
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

MK14_MOUSE
NC score	0.473956 (rank : 562)	θ value	0.365318 (rank : 726)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	561
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

DCAK2_MOUSE
NC score	0.473767 (rank : 563)	θ value	1.06291 (rank : 787)
Query Neighborhood Hits	1103	Target Neighborhood Hits	858	Shared Neighborhood Hits	559
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KAPCG_HUMAN
NC score	0.473520 (rank : 564)	θ value	0.0736092 (rank : 625)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	564
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

CDK7_HUMAN
NC score	0.473508 (rank : 565)	θ value	θ > 10 (rank : 1220)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	560
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

MK07_HUMAN
NC score	0.473319 (rank : 566)	θ value	2.36792 (rank : 892)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1087	Shared Neighborhood Hits	589
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

ACV1C_MOUSE
NC score	0.473207 (rank : 567)	θ value	8.99809 (rank : 1059)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	522
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

KCC4_HUMAN
NC score	0.473184 (rank : 568)	θ value	1.06291 (rank : 792)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	558
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

PKN3_HUMAN
NC score	0.472968 (rank : 569)	θ value	θ > 10 (rank : 1577)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	567
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

MK13_HUMAN
NC score	0.472902 (rank : 570)	θ value	0.00228821 (rank : 426)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	558
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

ACV1C_HUMAN
NC score	0.472895 (rank : 571)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	518
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

MASTL_HUMAN
NC score	0.472663 (rank : 572)	θ value	0.125558 (rank : 656)
Query Neighborhood Hits	1103	Target Neighborhood Hits	894	Shared Neighborhood Hits	569
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MYLK_HUMAN
NC score	0.472509 (rank : 573)	θ value	0.00102713 (rank : 366)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1328	Shared Neighborhood Hits	586
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CHK2_MOUSE
NC score	0.472124 (rank : 574)	θ value	0.0193708 (rank : 534)
Query Neighborhood Hits	1103	Target Neighborhood Hits	860	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KCC4_MOUSE
NC score	0.471871 (rank : 575)	θ value	0.0563607 (rank : 607)
Query Neighborhood Hits	1103	Target Neighborhood Hits	899	Shared Neighborhood Hits	575
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MYLK_MOUSE
NC score	0.471825 (rank : 576)	θ value	0.00102713 (rank : 367)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1489	Shared Neighborhood Hits	622
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MK04_HUMAN
NC score	0.471755 (rank : 577)	θ value	θ > 10 (rank : 1475)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	552
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK11_HUMAN
NC score	0.471486 (rank : 578)	θ value	0.163984 (rank : 673)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	553
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

KPCA_HUMAN
NC score	0.471471 (rank : 579)	θ value	0.0563607 (rank : 608)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1070	Shared Neighborhood Hits	562
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

DCAK2_HUMAN
NC score	0.471349 (rank : 580)	θ value	1.06291 (rank : 786)
Query Neighborhood Hits	1103	Target Neighborhood Hits	862	Shared Neighborhood Hits	557
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

PASK_MOUSE
NC score	0.471337 (rank : 581)	θ value	8.99809 (rank : 1085)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	557
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

MK13_MOUSE
NC score	0.471021 (rank : 582)	θ value	0.0193708 (rank : 544)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

AVR2A_MOUSE
NC score	0.470761 (rank : 583)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	1103	Target Neighborhood Hits	767	Shared Neighborhood Hits	543
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.470750 (rank : 584)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	1103	Target Neighborhood Hits	767	Shared Neighborhood Hits	543
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

PCTK2_MOUSE
NC score	0.470109 (rank : 585)	θ value	θ > 10 (rank : 1554)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	556
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

CDKL4_HUMAN
NC score	0.470082 (rank : 586)	θ value	θ > 10 (rank : 1228)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	558
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PCTK2_HUMAN
NC score	0.470015 (rank : 587)	θ value	θ > 10 (rank : 1553)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	556
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_MOUSE
NC score	0.468627 (rank : 588)	θ value	θ > 10 (rank : 1556)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	555
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

KPCB_MOUSE
NC score	0.468524 (rank : 589)	θ value	θ > 10 (rank : 1436)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1117	Shared Neighborhood Hits	560
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MK04_MOUSE
NC score	0.468506 (rank : 590)	θ value	θ > 10 (rank : 1476)
Query Neighborhood Hits	1103	Target Neighborhood Hits	852	Shared Neighborhood Hits	552
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

PCTK1_MOUSE
NC score	0.468116 (rank : 591)	θ value	θ > 10 (rank : 1552)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	556
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

TLK2_MOUSE
NC score	0.467944 (rank : 592)	θ value	θ > 10 (rank : 1740)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1088	Shared Neighborhood Hits	590
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

AMHR2_HUMAN
NC score	0.467801 (rank : 593)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	488
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

PCTK1_HUMAN
NC score	0.467777 (rank : 594)	θ value	θ > 10 (rank : 1551)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

KPCB_HUMAN
NC score	0.467440 (rank : 595)	θ value	θ > 10 (rank : 1435)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1121	Shared Neighborhood Hits	560
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MAPK3_MOUSE
NC score	0.467199 (rank : 596)	θ value	0.00134147 (rank : 387)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	542
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

TLK2_HUMAN
NC score	0.467018 (rank : 597)	θ value	θ > 10 (rank : 1739)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1044	Shared Neighborhood Hits	571
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

SGK1_HUMAN
NC score	0.466497 (rank : 598)	θ value	θ > 10 (rank : 1639)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	563
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

KS6A4_MOUSE
NC score	0.466367 (rank : 599)	θ value	0.00298849 (rank : 440)
Query Neighborhood Hits	1103	Target Neighborhood Hits	866	Shared Neighborhood Hits	571
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

CHK2_HUMAN
NC score	0.466189 (rank : 600)	θ value	0.125558 (rank : 652)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	559
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

PASK_HUMAN
NC score	0.465991 (rank : 601)	θ value	θ > 10 (rank : 1550)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	548
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

MK11_MOUSE
NC score	0.465745 (rank : 602)	θ value	0.279714 (rank : 703)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	556
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

SGK1_MOUSE
NC score	0.465712 (rank : 603)	θ value	θ > 10 (rank : 1640)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	564
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

KS6A4_HUMAN
NC score	0.465270 (rank : 604)	θ value	0.00869519 (rank : 485)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	573
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

PCTK3_HUMAN
NC score	0.465035 (rank : 605)	θ value	θ > 10 (rank : 1555)
Query Neighborhood Hits	1103	Target Neighborhood Hits	827	Shared Neighborhood Hits	553
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

KS6A5_HUMAN
NC score	0.464294 (rank : 606)	θ value	0.00175202 (rank : 404)
Query Neighborhood Hits	1103	Target Neighborhood Hits	855	Shared Neighborhood Hits	569
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

ST32B_MOUSE
NC score	0.463830 (rank : 607)	θ value	θ > 10 (rank : 1701)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	553
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

CDKL5_HUMAN
NC score	0.463562 (rank : 608)	θ value	θ > 10 (rank : 1230)
Query Neighborhood Hits	1103	Target Neighborhood Hits	967	Shared Neighborhood Hits	586
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

MAPK2_HUMAN
NC score	0.463060 (rank : 609)	θ value	0.21417 (rank : 685)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	557
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

KPCE_MOUSE
NC score	0.462697 (rank : 610)	θ value	0.0113563 (rank : 504)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	559
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KCC2G_HUMAN
NC score	0.462653 (rank : 611)	θ value	3.0926 (rank : 918)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	556
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
NC score	0.462600 (rank : 612)	θ value	3.0926 (rank : 919)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	556
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KAPCB_HUMAN
NC score	0.462555 (rank : 613)	θ value	1.38821 (rank : 828)
Query Neighborhood Hits	1103	Target Neighborhood Hits	837	Shared Neighborhood Hits	560
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_MOUSE
NC score	0.462081 (rank : 614)	θ value	1.06291 (rank : 791)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	558
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

CDKL1_HUMAN
NC score	0.462069 (rank : 615)	θ value	θ > 10 (rank : 1224)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	561
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

ST32B_HUMAN
NC score	0.461976 (rank : 616)	θ value	θ > 10 (rank : 1700)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	555
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

MK15_HUMAN
NC score	0.461892 (rank : 617)	θ value	θ > 10 (rank : 1479)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1038	Shared Neighborhood Hits	588
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK10_HUMAN
NC score	0.461845 (rank : 618)	θ value	0.0193708 (rank : 543)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	561
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

KPCE_HUMAN
NC score	0.461812 (rank : 619)	θ value	0.0148317 (rank : 520)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	559
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

CCRK_HUMAN
NC score	0.461789 (rank : 620)	θ value	θ > 10 (rank : 1203)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	561
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

KAPCA_HUMAN
NC score	0.461730 (rank : 621)	θ value	1.38821 (rank : 827)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	560
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MAPK2_MOUSE
NC score	0.461360 (rank : 622)	θ value	0.21417 (rank : 686)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	555
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MK10_MOUSE
NC score	0.461135 (rank : 623)	θ value	0.0563607 (rank : 610)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	561
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK09_HUMAN
NC score	0.460762 (rank : 624)	θ value	0.00228821 (rank : 425)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	564
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

KAPCB_MOUSE
NC score	0.460550 (rank : 625)	θ value	2.36792 (rank : 891)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	560
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

SGK2_HUMAN
NC score	0.460484 (rank : 626)	θ value	0.365318 (rank : 733)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	560
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

PHKG2_MOUSE
NC score	0.460138 (rank : 627)	θ value	5.27518 (rank : 1008)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	561
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

KPCG_MOUSE
NC score	0.459464 (rank : 628)	θ value	0.00869519 (rank : 484)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1123	Shared Neighborhood Hits	566
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.459208 (rank : 629)	θ value	0.00869519 (rank : 483)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1126	Shared Neighborhood Hits	566
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SGK2_MOUSE
NC score	0.459173 (rank : 630)	θ value	3.0926 (rank : 940)
Query Neighborhood Hits	1103	Target Neighborhood Hits	833	Shared Neighborhood Hits	559
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

TLK1_HUMAN
NC score	0.459116 (rank : 631)	θ value	θ > 10 (rank : 1737)
Query Neighborhood Hits	1103	Target Neighborhood Hits	967	Shared Neighborhood Hits	549
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

WEE1_MOUSE
NC score	0.458573 (rank : 632)	θ value	θ > 10 (rank : 1794)
Query Neighborhood Hits	1103	Target Neighborhood Hits	794	Shared Neighborhood Hits	524
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

AKT3_MOUSE
NC score	0.458484 (rank : 633)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	566
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT3_HUMAN
NC score	0.458462 (rank : 634)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	566
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

KS6A5_MOUSE
NC score	0.458410 (rank : 635)	θ value	0.0148317 (rank : 521)
Query Neighborhood Hits	1103	Target Neighborhood Hits	854	Shared Neighborhood Hits	568
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

TLK1_MOUSE
NC score	0.458379 (rank : 636)	θ value	θ > 10 (rank : 1738)
Query Neighborhood Hits	1103	Target Neighborhood Hits	947	Shared Neighborhood Hits	543
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

AKT2_HUMAN
NC score	0.458375 (rank : 637)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	565
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

GRK4_MOUSE
NC score	0.458258 (rank : 638)	θ value	θ > 10 (rank : 1379)
Query Neighborhood Hits	1103	Target Neighborhood Hits	808	Shared Neighborhood Hits	540
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

AKT2_MOUSE
NC score	0.457954 (rank : 639)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	563
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CDKL1_MOUSE
NC score	0.457850 (rank : 640)	θ value	θ > 10 (rank : 1225)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	558
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CD2L6_MOUSE
NC score	0.457575 (rank : 641)	θ value	0.00134147 (rank : 378)
Query Neighborhood Hits	1103	Target Neighborhood Hits	851	Shared Neighborhood Hits	554
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.457534 (rank : 642)	θ value	0.00134147 (rank : 377)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	549
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

GRK6_MOUSE
NC score	0.457460 (rank : 643)	θ value	θ > 10 (rank : 1383)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	550
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KCC2A_HUMAN
NC score	0.457269 (rank : 644)	θ value	θ > 10 (rank : 1426)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	555
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

GRK6_HUMAN
NC score	0.456883 (rank : 645)	θ value	θ > 10 (rank : 1382)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	551
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ST32C_MOUSE
NC score	0.456843 (rank : 646)	θ value	θ > 10 (rank : 1702)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	552
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

MK08_MOUSE
NC score	0.456805 (rank : 647)	θ value	0.0330416 (rank : 580)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	559
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

KCC2B_HUMAN
NC score	0.456671 (rank : 648)	θ value	0.62314 (rank : 761)
Query Neighborhood Hits	1103	Target Neighborhood Hits	866	Shared Neighborhood Hits	556
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

TSSK3_HUMAN
NC score	0.456617 (rank : 649)	θ value	θ > 10 (rank : 1764)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	536
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MK08_HUMAN
NC score	0.456482 (rank : 650)	θ value	0.0330416 (rank : 579)
Query Neighborhood Hits	1103	Target Neighborhood Hits	834	Shared Neighborhood Hits	559
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

TSSK3_MOUSE
NC score	0.456256 (rank : 651)	θ value	θ > 10 (rank : 1765)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	537
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MK09_MOUSE
NC score	0.456160 (rank : 652)	θ value	0.00298849 (rank : 441)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	564
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

KPCL_MOUSE
NC score	0.456006 (rank : 653)	θ value	0.0961366 (rank : 637)
Query Neighborhood Hits	1103	Target Neighborhood Hits	891	Shared Neighborhood Hits	555
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MK06_HUMAN
NC score	0.455823 (rank : 654)	θ value	θ > 10 (rank : 1477)
Query Neighborhood Hits	1103	Target Neighborhood Hits	815	Shared Neighborhood Hits	540
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.455669 (rank : 655)	θ value	θ > 10 (rank : 1478)
Query Neighborhood Hits	1103	Target Neighborhood Hits	818	Shared Neighborhood Hits	542
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

ERN2_MOUSE
NC score	0.455569 (rank : 656)	θ value	θ > 10 (rank : 1338)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	544
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MAPK3_HUMAN
NC score	0.455414 (rank : 657)	θ value	0.00228821 (rank : 423)
Query Neighborhood Hits	1103	Target Neighborhood Hits	807	Shared Neighborhood Hits	536
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MYO3A_HUMAN
NC score	0.455407 (rank : 658)	θ value	5.27518 (rank : 1000)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1033	Shared Neighborhood Hits	615
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

KCC2D_HUMAN
NC score	0.455370 (rank : 659)	θ value	θ > 10 (rank : 1428)
Query Neighborhood Hits	1103	Target Neighborhood Hits	830	Shared Neighborhood Hits	554
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

CCRK_MOUSE
NC score	0.455252 (rank : 660)	θ value	θ > 10 (rank : 1204)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

ERN2_HUMAN
NC score	0.455220 (rank : 661)	θ value	θ > 10 (rank : 1337)
Query Neighborhood Hits	1103	Target Neighborhood Hits	844	Shared Neighborhood Hits	549
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KCC2B_MOUSE
NC score	0.454763 (rank : 662)	θ value	0.62314 (rank : 762)
Query Neighborhood Hits	1103	Target Neighborhood Hits	841	Shared Neighborhood Hits	554
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

ST32C_HUMAN
NC score	0.454401 (rank : 663)	θ value	1.06291 (rank : 805)
Query Neighborhood Hits	1103	Target Neighborhood Hits	832	Shared Neighborhood Hits	558
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

KCC2A_MOUSE
NC score	0.454338 (rank : 664)	θ value	θ > 10 (rank : 1427)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	553
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

CDK8_HUMAN
NC score	0.454185 (rank : 665)	θ value	0.00175202 (rank : 399)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	549
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

GRK4_HUMAN
NC score	0.453941 (rank : 666)	θ value	θ > 10 (rank : 1378)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	547
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

PHKG2_HUMAN
NC score	0.453881 (rank : 667)	θ value	4.03905 (rank : 967)
Query Neighborhood Hits	1103	Target Neighborhood Hits	839	Shared Neighborhood Hits	561
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

SGK3_MOUSE
NC score	0.453850 (rank : 668)	θ value	θ > 10 (rank : 1642)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	559
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

MYO3A_MOUSE
NC score	0.453622 (rank : 669)	θ value	1.81305 (rank : 866)
Query Neighborhood Hits	1103	Target Neighborhood Hits	902	Shared Neighborhood Hits	578
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

ULK4_MOUSE
NC score	0.453040 (rank : 670)	θ value	θ > 10 (rank : 1776)
Query Neighborhood Hits	1103	Target Neighborhood Hits	793	Shared Neighborhood Hits	542
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

SGK3_HUMAN
NC score	0.452853 (rank : 671)	θ value	θ > 10 (rank : 1641)
Query Neighborhood Hits	1103	Target Neighborhood Hits	877	Shared Neighborhood Hits	558
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

KPCL_HUMAN
NC score	0.452486 (rank : 672)	θ value	0.365318 (rank : 720)
Query Neighborhood Hits	1103	Target Neighborhood Hits	887	Shared Neighborhood Hits	555
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MAST4_HUMAN
NC score	0.451806 (rank : 673)	θ value	0.0193708 (rank : 541)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1804	Shared Neighborhood Hits	665
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PMYT1_MOUSE
NC score	0.451651 (rank : 674)	θ value	θ > 10 (rank : 1583)
Query Neighborhood Hits	1103	Target Neighborhood Hits	910	Shared Neighborhood Hits	566
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

RN5A_HUMAN
NC score	0.450639 (rank : 675)	θ value	0.0563607 (rank : 613)
Query Neighborhood Hits	1103	Target Neighborhood Hits	608	Shared Neighborhood Hits	438
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

AKT1_HUMAN
NC score	0.450340 (rank : 676)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	1103	Target Neighborhood Hits	885	Shared Neighborhood Hits	564
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

MAST3_HUMAN
NC score	0.450089 (rank : 677)	θ value	0.0193708 (rank : 540)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1128	Shared Neighborhood Hits	594
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST2_MOUSE
NC score	0.449481 (rank : 678)	θ value	0.00035302 (rank : 338)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1110	Shared Neighborhood Hits	594
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

AKT1_MOUSE
NC score	0.449348 (rank : 679)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	1103	Target Neighborhood Hits	878	Shared Neighborhood Hits	564
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

TTK_HUMAN
NC score	0.449320 (rank : 680)	θ value	θ > 10 (rank : 1771)
Query Neighborhood Hits	1103	Target Neighborhood Hits	816	Shared Neighborhood Hits	516
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

KPCI_HUMAN
NC score	0.449235 (rank : 681)	θ value	0.0252991 (rank : 556)
Query Neighborhood Hits	1103	Target Neighborhood Hits	885	Shared Neighborhood Hits	566
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

PHKG1_HUMAN
NC score	0.448827 (rank : 682)	θ value	1.38821 (rank : 838)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	562
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

GRK5_MOUSE
NC score	0.448800 (rank : 683)	θ value	θ > 10 (rank : 1381)
Query Neighborhood Hits	1103	Target Neighborhood Hits	823	Shared Neighborhood Hits	544
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

MAST2_HUMAN
NC score	0.448728 (rank : 684)	θ value	0.000270298 (rank : 325)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1189	Shared Neighborhood Hits	610
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

GRK5_HUMAN
NC score	0.448650 (rank : 685)	θ value	θ > 10 (rank : 1380)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	544
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KPCI_MOUSE
NC score	0.448592 (rank : 686)	θ value	0.0252991 (rank : 557)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	566
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

PIM2_HUMAN
NC score	0.448094 (rank : 687)	θ value	θ > 10 (rank : 1566)
Query Neighborhood Hits	1103	Target Neighborhood Hits	808	Shared Neighborhood Hits	547
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

AVR2B_MOUSE
NC score	0.447426 (rank : 688)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	1103	Target Neighborhood Hits	749	Shared Neighborhood Hits	536
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.447152 (rank : 689)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	536
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

MK15_MOUSE
NC score	0.446833 (rank : 690)	θ value	θ > 10 (rank : 1480)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	558
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

UHMK1_MOUSE
NC score	0.446501 (rank : 691)	θ value	θ > 10 (rank : 1775)
Query Neighborhood Hits	1103	Target Neighborhood Hits	809	Shared Neighborhood Hits	516
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

PHKG1_MOUSE
NC score	0.446175 (rank : 692)	θ value	θ > 10 (rank : 1561)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	561
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

UHMK1_HUMAN
NC score	0.445461 (rank : 693)	θ value	θ > 10 (rank : 1774)
Query Neighborhood Hits	1103	Target Neighborhood Hits	808	Shared Neighborhood Hits	516
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

MOK_HUMAN
NC score	0.444463 (rank : 694)	θ value	4.03905 (rank : 960)
Query Neighborhood Hits	1103	Target Neighborhood Hits	807	Shared Neighborhood Hits	531
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MAST1_HUMAN
NC score	0.444258 (rank : 695)	θ value	0.0193708 (rank : 538)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1146	Shared Neighborhood Hits	589
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RK_MOUSE
NC score	0.444000 (rank : 696)	θ value	θ > 10 (rank : 1616)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	549
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MAST1_MOUSE
NC score	0.443917 (rank : 697)	θ value	0.0193708 (rank : 539)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1123	Shared Neighborhood Hits	587
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

WEE1B_MOUSE
NC score	0.442730 (rank : 698)	θ value	0.00869519 (rank : 489)
Query Neighborhood Hits	1103	Target Neighborhood Hits	765	Shared Neighborhood Hits	513
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

MOK_MOUSE
NC score	0.442533 (rank : 699)	θ value	θ > 10 (rank : 1482)
Query Neighborhood Hits	1103	Target Neighborhood Hits	796	Shared Neighborhood Hits	528
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

RK_HUMAN
NC score	0.442192 (rank : 700)	θ value	θ > 10 (rank : 1615)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	551
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

GAK_HUMAN
NC score	0.441447 (rank : 701)	θ value	θ > 10 (rank : 1352)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1028	Shared Neighborhood Hits	564
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PIM2_MOUSE
NC score	0.441057 (rank : 702)	θ value	θ > 10 (rank : 1567)
Query Neighborhood Hits	1103	Target Neighborhood Hits	809	Shared Neighborhood Hits	544
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

CSKP_MOUSE
NC score	0.440223 (rank : 703)	θ value	0.000270298 (rank : 323)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1027	Shared Neighborhood Hits	552
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PINK1_MOUSE
NC score	0.439699 (rank : 704)	θ value	θ > 10 (rank : 1572)
Query Neighborhood Hits	1103	Target Neighborhood Hits	726	Shared Neighborhood Hits	515
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

MKNK2_HUMAN
NC score	0.439662 (rank : 705)	θ value	0.00390308 (rank : 454)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	550
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MYO3B_HUMAN
NC score	0.439516 (rank : 706)	θ value	θ > 10 (rank : 1498)
Query Neighborhood Hits	1103	Target Neighborhood Hits	923	Shared Neighborhood Hits	577
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

CSKP_HUMAN
NC score	0.439006 (rank : 707)	θ value	0.000270298 (rank : 322)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1022	Shared Neighborhood Hits	552
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

GSK3A_HUMAN
NC score	0.438960 (rank : 708)	θ value	2.36792 (rank : 887)
Query Neighborhood Hits	1103	Target Neighborhood Hits	835	Shared Neighborhood Hits	543
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

WEE1_HUMAN
NC score	0.438345 (rank : 709)	θ value	θ > 10 (rank : 1793)
Query Neighborhood Hits	1103	Target Neighborhood Hits	777	Shared Neighborhood Hits	510
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

KPCZ_MOUSE
NC score	0.438183 (rank : 710)	θ value	0.365318 (rank : 722)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	565
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.437960 (rank : 711)	θ value	0.47712 (rank : 743)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	565
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

TTK_MOUSE
NC score	0.437868 (rank : 712)	θ value	θ > 10 (rank : 1772)
Query Neighborhood Hits	1103	Target Neighborhood Hits	803	Shared Neighborhood Hits	496
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

PMYT1_HUMAN
NC score	0.437216 (rank : 713)	θ value	θ > 10 (rank : 1582)
Query Neighborhood Hits	1103	Target Neighborhood Hits	814	Shared Neighborhood Hits	552
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

FANK1_MOUSE
NC score	0.434201 (rank : 714)	θ value	8.40245e-06 (rank : 190)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	246
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

PIM1_HUMAN
NC score	0.434058 (rank : 715)	θ value	θ > 10 (rank : 1564)
Query Neighborhood Hits	1103	Target Neighborhood Hits	797	Shared Neighborhood Hits	533
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

MKNK2_MOUSE
NC score	0.433389 (rank : 716)	θ value	0.00665767 (rank : 475)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	549
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

BMP2K_HUMAN
NC score	0.432131 (rank : 717)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	544
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

ASB8_HUMAN
NC score	0.432106 (rank : 718)	θ value	1.38499e-08 (rank : 81)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ASB8_MOUSE
NC score	0.431946 (rank : 719)	θ value	1.38499e-08 (rank : 82)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	238
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

PIM1_MOUSE
NC score	0.431334 (rank : 720)	θ value	θ > 10 (rank : 1565)
Query Neighborhood Hits	1103	Target Neighborhood Hits	787	Shared Neighborhood Hits	525
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

CAMKV_MOUSE
NC score	0.430833 (rank : 721)	θ value	3.0926 (rank : 908)
Query Neighborhood Hits	1103	Target Neighborhood Hits	848	Shared Neighborhood Hits	538
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

ANR50_HUMAN
NC score	0.430521 (rank : 722)	θ value	1.38499e-08 (rank : 79)
Query Neighborhood Hits	1103	Target Neighborhood Hits	361	Shared Neighborhood Hits	251
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

HIPK4_HUMAN
NC score	0.429840 (rank : 723)	θ value	θ > 10 (rank : 1396)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	532
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

FANK1_HUMAN
NC score	0.429512 (rank : 724)	θ value	1.69304e-06 (rank : 145)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	242
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

OBSCN_HUMAN
NC score	0.429381 (rank : 725)	θ value	0.00228821 (rank : 427)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1931	Shared Neighborhood Hits	620
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

CAMKV_HUMAN
NC score	0.429257 (rank : 726)	θ value	3.0926 (rank : 907)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1084	Shared Neighborhood Hits	563
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

SPEG_HUMAN
NC score	0.429028 (rank : 727)	θ value	θ > 10 (rank : 1685)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1762	Shared Neighborhood Hits	614
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GAK_MOUSE
NC score	0.428512 (rank : 728)	θ value	θ > 10 (rank : 1353)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	552
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PIM3_HUMAN
NC score	0.428268 (rank : 729)	θ value	θ > 10 (rank : 1568)
Query Neighborhood Hits	1103	Target Neighborhood Hits	789	Shared Neighborhood Hits	529
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

GRK7_HUMAN
NC score	0.428180 (rank : 730)	θ value	θ > 10 (rank : 1384)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	548
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

BMP2K_MOUSE
NC score	0.427853 (rank : 731)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	1103	Target Neighborhood Hits	874	Shared Neighborhood Hits	539
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

PSD10_MOUSE
NC score	0.427462 (rank : 732)	θ value	4.92598e-06 (rank : 181)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	240
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

GSK3B_HUMAN
NC score	0.427380 (rank : 733)	θ value	θ > 10 (rank : 1385)
Query Neighborhood Hits	1103	Target Neighborhood Hits	801	Shared Neighborhood Hits	537
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

SPEG_MOUSE
NC score	0.426905 (rank : 734)	θ value	θ > 10 (rank : 1686)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1959	Shared Neighborhood Hits	646
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GSK3B_MOUSE
NC score	0.426821 (rank : 735)	θ value	θ > 10 (rank : 1386)
Query Neighborhood Hits	1103	Target Neighborhood Hits	800	Shared Neighborhood Hits	536
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

WEE1B_HUMAN
NC score	0.426759 (rank : 736)	θ value	θ > 10 (rank : 1792)
Query Neighborhood Hits	1103	Target Neighborhood Hits	836	Shared Neighborhood Hits	525
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

ASB3_MOUSE
NC score	0.426408 (rank : 737)	θ value	5.81887e-07 (rank : 126)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	241
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

PSD10_HUMAN
NC score	0.426339 (rank : 738)	θ value	1.09739e-05 (rank : 198)
Query Neighborhood Hits	1103	Target Neighborhood Hits	301	Shared Neighborhood Hits	241
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR44_HUMAN
NC score	0.425313 (rank : 739)	θ value	4.76016e-09 (rank : 64)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	245
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ASB3_HUMAN
NC score	0.423516 (rank : 740)	θ value	2.21117e-06 (rank : 153)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	241
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANK3_HUMAN
NC score	0.423087 (rank : 741)	θ value	2.79066e-09 (rank : 60)
Query Neighborhood Hits	1103	Target Neighborhood Hits	853	Shared Neighborhood Hits	350
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANR28_HUMAN
NC score	0.422296 (rank : 742)	θ value	5.81887e-07 (rank : 124)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	244
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

TRIO_HUMAN
NC score	0.422265 (rank : 743)	θ value	3.0926 (rank : 944)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1580	Shared Neighborhood Hits	634
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PIM3_MOUSE
NC score	0.422047 (rank : 744)	θ value	θ > 10 (rank : 1569)
Query Neighborhood Hits	1103	Target Neighborhood Hits	783	Shared Neighborhood Hits	525
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

ANR28_MOUSE
NC score	0.421945 (rank : 745)	θ value	4.45536e-07 (rank : 114)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	243
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR29_HUMAN
NC score	0.420387 (rank : 746)	θ value	0.00509761 (rank : 461)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	237
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANK1_MOUSE
NC score	0.420331 (rank : 747)	θ value	6.21693e-09 (rank : 68)
Query Neighborhood Hits	1103	Target Neighborhood Hits	430	Shared Neighborhood Hits	268
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANKS1_HUMAN
NC score	0.420247 (rank : 748)	θ value	3.77169e-06 (rank : 169)
Query Neighborhood Hits	1103	Target Neighborhood Hits	438	Shared Neighborhood Hits	275
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANR52_MOUSE
NC score	0.420043 (rank : 749)	θ value	1.38499e-08 (rank : 80)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	241
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANK1_HUMAN
NC score	0.419970 (rank : 750)	θ value	6.21693e-09 (rank : 67)
Query Neighborhood Hits	1103	Target Neighborhood Hits	416	Shared Neighborhood Hits	262
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANR23_HUMAN
NC score	0.419473 (rank : 751)	θ value	9.29e-05 (rank : 278)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	238
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

INVS_HUMAN
NC score	0.418983 (rank : 752)	θ value	1.87187e-05 (rank : 214)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	267
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

ANR52_HUMAN
NC score	0.418880 (rank : 753)	θ value	6.87365e-08 (rank : 95)
Query Neighborhood Hits	1103	Target Neighborhood Hits	322	Shared Neighborhood Hits	241
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANR23_MOUSE
NC score	0.417775 (rank : 754)	θ value	0.000461057 (rank : 345)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	239
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

AAK1_HUMAN
NC score	0.417606 (rank : 755)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1077	Shared Neighborhood Hits	568
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ANKR2_HUMAN
NC score	0.417436 (rank : 756)	θ value	0.000461057 (rank : 342)
Query Neighborhood Hits	1103	Target Neighborhood Hits	321	Shared Neighborhood Hits	248
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

AAK1_MOUSE
NC score	0.417347 (rank : 757)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1051	Shared Neighborhood Hits	565
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ASB13_HUMAN
NC score	0.417280 (rank : 758)	θ value	1.43324e-05 (rank : 202)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	239
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASB13_MOUSE
NC score	0.417236 (rank : 759)	θ value	1.09739e-05 (rank : 192)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	239
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ANR42_MOUSE
NC score	0.417194 (rank : 760)	θ value	6.43352e-06 (rank : 182)
Query Neighborhood Hits	1103	Target Neighborhood Hits	334	Shared Neighborhood Hits	243
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB2_HUMAN
NC score	0.417193 (rank : 761)	θ value	1.09739e-05 (rank : 193)
Query Neighborhood Hits	1103	Target Neighborhood Hits	309	Shared Neighborhood Hits	244
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANKR6_HUMAN
NC score	0.417134 (rank : 762)	θ value	0.000602161 (rank : 353)
Query Neighborhood Hits	1103	Target Neighborhood Hits	439	Shared Neighborhood Hits	277
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

F5006_MOUSE
NC score	0.416480 (rank : 763)	θ value	θ > 10 (rank : 1345)
Query Neighborhood Hits	1103	Target Neighborhood Hits	793	Shared Neighborhood Hits	542
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

ANKS1_MOUSE
NC score	0.416474 (rank : 764)	θ value	1.43324e-05 (rank : 201)
Query Neighborhood Hits	1103	Target Neighborhood Hits	453	Shared Neighborhood Hits	279
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANKR1_MOUSE
NC score	0.416048 (rank : 765)	θ value	9.29e-05 (rank : 277)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	241
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANKR2_MOUSE
NC score	0.416026 (rank : 766)	θ value	0.000270298 (rank : 318)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	244
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

CTRO_HUMAN
NC score	0.415830 (rank : 767)	θ value	1.06291 (rank : 784)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2092	Shared Neighborhood Hits	713
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ANKR1_HUMAN
NC score	0.415807 (rank : 768)	θ value	0.00020696 (rank : 304)
Query Neighborhood Hits	1103	Target Neighborhood Hits	308	Shared Neighborhood Hits	244
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

INVS_MOUSE
NC score	0.415320 (rank : 769)	θ value	1.87187e-05 (rank : 215)
Query Neighborhood Hits	1103	Target Neighborhood Hits	609	Shared Neighborhood Hits	289
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ARBK1_HUMAN
NC score	0.414173 (rank : 770)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	1103	Target Neighborhood Hits	859	Shared Neighborhood Hits	553
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ANR39_MOUSE
NC score	0.413927 (rank : 771)	θ value	0.000270298 (rank : 319)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	238
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_HUMAN
NC score	0.413733 (rank : 772)	θ value	0.00035302 (rank : 330)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	238
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

CSKI1_HUMAN
NC score	0.413700 (rank : 773)	θ value	0.00228821 (rank : 417)
Query Neighborhood Hits	1103	Target Neighborhood Hits	997	Shared Neighborhood Hits	333
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANR42_HUMAN
NC score	0.413207 (rank : 774)	θ value	0.000270298 (rank : 320)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	236
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

MKNK1_MOUSE
NC score	0.413201 (rank : 775)	θ value	6.88961 (rank : 1037)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	533
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MRCKG_MOUSE
NC score	0.413166 (rank : 776)	θ value	4.03905 (rank : 961)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1466	Shared Neighborhood Hits	646
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

ASB1_MOUSE
NC score	0.413112 (rank : 777)	θ value	5.81887e-07 (rank : 125)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	233
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

PRP4B_HUMAN
NC score	0.413032 (rank : 778)	θ value	θ > 10 (rank : 1586)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1030	Shared Neighborhood Hits	586
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

GABP2_HUMAN
NC score	0.412708 (rank : 779)	θ value	0.000158464 (rank : 298)
Query Neighborhood Hits	1103	Target Neighborhood Hits	454	Shared Neighborhood Hits	277
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

GABP2_MOUSE
NC score	0.412701 (rank : 780)	θ value	0.000461057 (rank : 346)
Query Neighborhood Hits	1103	Target Neighborhood Hits	429	Shared Neighborhood Hits	272
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ASB2_MOUSE
NC score	0.412528 (rank : 781)	θ value	0.00020696 (rank : 307)
Query Neighborhood Hits	1103	Target Neighborhood Hits	321	Shared Neighborhood Hits	244
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

TNKS1_HUMAN
NC score	0.412455 (rank : 782)	θ value	0.00102713 (rank : 371)
Query Neighborhood Hits	1103	Target Neighborhood Hits	477	Shared Neighborhood Hits	274
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

PRP4B_MOUSE
NC score	0.412358 (rank : 783)	θ value	θ > 10 (rank : 1587)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1040	Shared Neighborhood Hits	589
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

MRCKG_HUMAN
NC score	0.412248 (rank : 784)	θ value	6.88961 (rank : 1038)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1519	Shared Neighborhood Hits	650
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

ANKS3_MOUSE
NC score	0.411939 (rank : 785)	θ value	4.1701e-05 (rank : 244)
Query Neighborhood Hits	1103	Target Neighborhood Hits	355	Shared Neighborhood Hits	246
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

CSKI1_MOUSE
NC score	0.411879 (rank : 786)	θ value	0.00228821 (rank : 418)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1031	Shared Neighborhood Hits	340
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASB1_HUMAN
NC score	0.411795 (rank : 787)	θ value	1.29631e-06 (rank : 142)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ROCK1_HUMAN
NC score	0.411425 (rank : 788)	θ value	1.06291 (rank : 801)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2000	Shared Neighborhood Hits	705
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

PA2G6_MOUSE
NC score	0.411247 (rank : 789)	θ value	2.21117e-06 (rank : 161)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	237
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

PINK1_HUMAN
NC score	0.411236 (rank : 790)	θ value	θ > 10 (rank : 1571)
Query Neighborhood Hits	1103	Target Neighborhood Hits	741	Shared Neighborhood Hits	500
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

ANKS6_MOUSE
NC score	0.410965 (rank : 791)	θ value	3.19293e-05 (rank : 238)
Query Neighborhood Hits	1103	Target Neighborhood Hits	435	Shared Neighborhood Hits	255
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ARBK1_MOUSE
NC score	0.410025 (rank : 792)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	554
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

TNKS2_HUMAN
NC score	0.409974 (rank : 793)	θ value	0.000786445 (rank : 362)
Query Neighborhood Hits	1103	Target Neighborhood Hits	361	Shared Neighborhood Hits	249
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

PA2G6_HUMAN
NC score	0.409582 (rank : 794)	θ value	5.44631e-05 (rank : 261)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	234
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ASB15_HUMAN
NC score	0.409518 (rank : 795)	θ value	1.29631e-06 (rank : 140)
Query Neighborhood Hits	1103	Target Neighborhood Hits	305	Shared Neighborhood Hits	237
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

CDN2D_HUMAN
NC score	0.409511 (rank : 796)	θ value	7.1131e-05 (rank : 268)
Query Neighborhood Hits	1103	Target Neighborhood Hits	268	Shared Neighborhood Hits	234
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

DUET_HUMAN
NC score	0.409459 (rank : 797)	θ value	θ > 10 (rank : 1320)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1220	Shared Neighborhood Hits	563
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ROCK2_HUMAN
NC score	0.409303 (rank : 798)	θ value	θ > 10 (rank : 1623)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2073	Shared Neighborhood Hits	716
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CTRO_MOUSE
NC score	0.409296 (rank : 799)	θ value	1.38821 (rank : 817)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2344	Shared Neighborhood Hits	742
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ARBK2_HUMAN
NC score	0.408861 (rank : 800)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	1103	Target Neighborhood Hits	849	Shared Neighborhood Hits	552
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ASB7_MOUSE
NC score	0.408833 (rank : 801)	θ value	0.0113563 (rank : 497)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	238
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_HUMAN
NC score	0.408214 (rank : 802)	θ value	0.0113563 (rank : 496)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ANR16_HUMAN
NC score	0.408180 (rank : 803)	θ value	0.21417 (rank : 679)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	238
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

GABP3_MOUSE
NC score	0.408101 (rank : 804)	θ value	0.0113563 (rank : 502)
Query Neighborhood Hits	1103	Target Neighborhood Hits	330	Shared Neighborhood Hits	247
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

HIPK3_MOUSE
NC score	0.407909 (rank : 805)	θ value	θ > 10 (rank : 1395)
Query Neighborhood Hits	1103	Target Neighborhood Hits	857	Shared Neighborhood Hits	547
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_HUMAN
NC score	0.407789 (rank : 806)	θ value	θ > 10 (rank : 1394)
Query Neighborhood Hits	1103	Target Neighborhood Hits	867	Shared Neighborhood Hits	554
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

ANKS6_HUMAN
NC score	0.407175 (rank : 807)	θ value	0.00020696 (rank : 305)
Query Neighborhood Hits	1103	Target Neighborhood Hits	411	Shared Neighborhood Hits	252
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ANK2_HUMAN
NC score	0.407147 (rank : 808)	θ value	2.79066e-09 (rank : 59)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1615	Shared Neighborhood Hits	424
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANKS3_HUMAN
NC score	0.406697 (rank : 809)	θ value	0.000461057 (rank : 343)
Query Neighborhood Hits	1103	Target Neighborhood Hits	355	Shared Neighborhood Hits	253
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

STK38_MOUSE
NC score	0.406679 (rank : 810)	θ value	θ > 10 (rank : 1719)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	551
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_HUMAN
NC score	0.406221 (rank : 811)	θ value	θ > 10 (rank : 1718)
Query Neighborhood Hits	1103	Target Neighborhood Hits	840	Shared Neighborhood Hits	551
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

CSKI2_HUMAN
NC score	0.405954 (rank : 812)	θ value	0.163984 (rank : 668)
Query Neighborhood Hits	1103	Target Neighborhood Hits	747	Shared Neighborhood Hits	304
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
NC score	0.405842 (rank : 813)	θ value	0.21417 (rank : 682)
Query Neighborhood Hits	1103	Target Neighborhood Hits	812	Shared Neighborhood Hits	314
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ROCK1_MOUSE
NC score	0.405552 (rank : 814)	θ value	1.06291 (rank : 802)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2126	Shared Neighborhood Hits	718
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ASB10_HUMAN
NC score	0.405428 (rank : 815)	θ value	0.0736092 (rank : 619)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	243
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

MRCKA_HUMAN
NC score	0.404735 (rank : 816)	θ value	θ > 10 (rank : 1493)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1999	Shared Neighborhood Hits	703
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

ASB15_MOUSE
NC score	0.404609 (rank : 817)	θ value	1.29631e-06 (rank : 141)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

DMPK_MOUSE
NC score	0.404584 (rank : 818)	θ value	0.47712 (rank : 740)
Query Neighborhood Hits	1103	Target Neighborhood Hits	908	Shared Neighborhood Hits	561
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ROCK2_MOUSE
NC score	0.403982 (rank : 819)	θ value	θ > 10 (rank : 1624)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2072	Shared Neighborhood Hits	714
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

ASB14_MOUSE
NC score	0.403967 (rank : 820)	θ value	7.1131e-05 (rank : 266)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	237
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ASB10_MOUSE
NC score	0.402848 (rank : 821)	θ value	0.125558 (rank : 650)
Query Neighborhood Hits	1103	Target Neighborhood Hits	301	Shared Neighborhood Hits	243
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

BCL3_HUMAN
NC score	0.402684 (rank : 822)	θ value	0.00175202 (rank : 398)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	243
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

CDN2D_MOUSE
NC score	0.402177 (rank : 823)	θ value	0.00175202 (rank : 400)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	235
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

DMPK_HUMAN
NC score	0.402159 (rank : 824)	θ value	1.38821 (rank : 820)
Query Neighborhood Hits	1103	Target Neighborhood Hits	944	Shared Neighborhood Hits	567
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

HIPK1_HUMAN
NC score	0.402126 (rank : 825)	θ value	θ > 10 (rank : 1390)
Query Neighborhood Hits	1103	Target Neighborhood Hits	843	Shared Neighborhood Hits	539
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

ASZ1_HUMAN
NC score	0.401826 (rank : 826)	θ value	0.00228821 (rank : 416)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	238
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ST38L_HUMAN
NC score	0.401820 (rank : 827)	θ value	θ > 10 (rank : 1703)
Query Neighborhood Hits	1103	Target Neighborhood Hits	824	Shared Neighborhood Hits	547
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ANRA2_HUMAN
NC score	0.401727 (rank : 828)	θ value	0.00020696 (rank : 306)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	234
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

HIPK1_MOUSE
NC score	0.401543 (rank : 829)	θ value	θ > 10 (rank : 1391)
Query Neighborhood Hits	1103	Target Neighborhood Hits	838	Shared Neighborhood Hits	540
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

CT086_HUMAN
NC score	0.401513 (rank : 830)	θ value	0.0961366 (rank : 634)
Query Neighborhood Hits	1103	Target Neighborhood Hits	277	Shared Neighborhood Hits	235
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

ASZ1_MOUSE
NC score	0.401133 (rank : 831)	θ value	0.00175202 (rank : 397)
Query Neighborhood Hits	1103	Target Neighborhood Hits	319	Shared Neighborhood Hits	240
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

MYPT1_MOUSE
NC score	0.401104 (rank : 832)	θ value	0.000602161 (rank : 356)
Query Neighborhood Hits	1103	Target Neighborhood Hits	539	Shared Neighborhood Hits	291
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

RFXK_MOUSE
NC score	0.400853 (rank : 833)	θ value	0.00175202 (rank : 410)
Query Neighborhood Hits	1103	Target Neighborhood Hits	273	Shared Neighborhood Hits	236
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

LATS1_HUMAN
NC score	0.400657 (rank : 834)	θ value	θ > 10 (rank : 1447)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1057	Shared Neighborhood Hits	597
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

ANKR5_HUMAN
NC score	0.400309 (rank : 835)	θ value	0.00134147 (rank : 372)
Query Neighborhood Hits	1103	Target Neighborhood Hits	297	Shared Neighborhood Hits	240
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

PP16A_MOUSE
NC score	0.400098 (rank : 836)	θ value	5.44631e-05 (rank : 262)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	240
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ANKR5_MOUSE
NC score	0.399499 (rank : 837)	θ value	0.00134147 (rank : 373)
Query Neighborhood Hits	1103	Target Neighborhood Hits	298	Shared Neighborhood Hits	243
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANRA2_MOUSE
NC score	0.399370 (rank : 838)	θ value	0.00175202 (rank : 396)
Query Neighborhood Hits	1103	Target Neighborhood Hits	287	Shared Neighborhood Hits	234
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

F5006_HUMAN
NC score	0.398949 (rank : 839)	θ value	θ > 10 (rank : 1344)
Query Neighborhood Hits	1103	Target Neighborhood Hits	794	Shared Neighborhood Hits	534
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

BCL3_MOUSE
NC score	0.398350 (rank : 840)	θ value	0.00390308 (rank : 447)
Query Neighborhood Hits	1103	Target Neighborhood Hits	388	Shared Neighborhood Hits	249
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

TTBK1_HUMAN
NC score	0.398299 (rank : 841)	θ value	θ > 10 (rank : 1768)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1058	Shared Neighborhood Hits	510
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

LATS1_MOUSE
NC score	0.398166 (rank : 842)	θ value	θ > 10 (rank : 1448)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1027	Shared Neighborhood Hits	589
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

ASB11_MOUSE
NC score	0.398005 (rank : 843)	θ value	0.00228821 (rank : 415)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	228
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

MRCKB_MOUSE
NC score	0.397689 (rank : 844)	θ value	θ > 10 (rank : 1495)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2180	Shared Neighborhood Hits	723
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MAPK5_MOUSE
NC score	0.397308 (rank : 845)	θ value	θ > 10 (rank : 1472)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	525
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

ANR10_HUMAN
NC score	0.397303 (rank : 846)	θ value	0.00665767 (rank : 469)
Query Neighborhood Hits	1103	Target Neighborhood Hits	289	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

DYRK3_HUMAN
NC score	0.397292 (rank : 847)	θ value	θ > 10 (rank : 1326)
Query Neighborhood Hits	1103	Target Neighborhood Hits	798	Shared Neighborhood Hits	530
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

HIPK2_MOUSE
NC score	0.396997 (rank : 848)	θ value	θ > 10 (rank : 1393)
Query Neighborhood Hits	1103	Target Neighborhood Hits	871	Shared Neighborhood Hits	547
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

MYPT1_HUMAN
NC score	0.396568 (rank : 849)	θ value	0.000270298 (rank : 327)
Query Neighborhood Hits	1103	Target Neighborhood Hits	723	Shared Neighborhood Hits	330
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

HIPK2_HUMAN
NC score	0.395914 (rank : 850)	θ value	θ > 10 (rank : 1392)
Query Neighborhood Hits	1103	Target Neighborhood Hits	845	Shared Neighborhood Hits	541
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

ASB9_HUMAN
NC score	0.395819 (rank : 851)	θ value	0.0113563 (rank : 498)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	228
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

MIB1_HUMAN
NC score	0.395469 (rank : 852)	θ value	4.1701e-05 (rank : 247)
Query Neighborhood Hits	1103	Target Neighborhood Hits	470	Shared Neighborhood Hits	245
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

ANR46_MOUSE
NC score	0.395388 (rank : 853)	θ value	0.0563607 (rank : 603)
Query Neighborhood Hits	1103	Target Neighborhood Hits	274	Shared Neighborhood Hits	236
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ASB11_HUMAN
NC score	0.395323 (rank : 854)	θ value	0.00298849 (rank : 433)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	232
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

MIB1_MOUSE
NC score	0.395228 (rank : 855)	θ value	4.1701e-05 (rank : 248)
Query Neighborhood Hits	1103	Target Neighborhood Hits	471	Shared Neighborhood Hits	246
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

ANR10_MOUSE
NC score	0.395117 (rank : 856)	θ value	0.0113563 (rank : 493)
Query Neighborhood Hits	1103	Target Neighborhood Hits	273	Shared Neighborhood Hits	227
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ASB12_HUMAN
NC score	0.394979 (rank : 857)	θ value	0.00134147 (rank : 376)
Query Neighborhood Hits	1103	Target Neighborhood Hits	263	Shared Neighborhood Hits	233
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

RFXK_HUMAN
NC score	0.394863 (rank : 858)	θ value	0.0961366 (rank : 646)
Query Neighborhood Hits	1103	Target Neighborhood Hits	282	Shared Neighborhood Hits	233
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

MYPT2_HUMAN
NC score	0.394836 (rank : 859)	θ value	9.29e-05 (rank : 280)
Query Neighborhood Hits	1103	Target Neighborhood Hits	707	Shared Neighborhood Hits	302
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

OSTF1_MOUSE
NC score	0.394457 (rank : 860)	θ value	9.29e-05 (rank : 281)
Query Neighborhood Hits	1103	Target Neighborhood Hits	467	Shared Neighborhood Hits	256
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

MAPK5_HUMAN
NC score	0.394417 (rank : 861)	θ value	θ > 10 (rank : 1471)
Query Neighborhood Hits	1103	Target Neighborhood Hits	795	Shared Neighborhood Hits	520
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MRCKB_HUMAN
NC score	0.394346 (rank : 862)	θ value	θ > 10 (rank : 1494)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2239	Shared Neighborhood Hits	730
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TRPA1_HUMAN
NC score	0.394290 (rank : 863)	θ value	0.00509761 (rank : 467)
Query Neighborhood Hits	1103	Target Neighborhood Hits	339	Shared Neighborhood Hits	238
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

TRPA1_MOUSE
NC score	0.394156 (rank : 864)	θ value	0.0113563 (rank : 507)
Query Neighborhood Hits	1103	Target Neighborhood Hits	343	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANR49_HUMAN
NC score	0.393899 (rank : 865)	θ value	0.62314 (rank : 755)
Query Neighborhood Hits	1103	Target Neighborhood Hits	282	Shared Neighborhood Hits	235
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

IKBE_MOUSE
NC score	0.393827 (rank : 866)	θ value	5.44631e-05 (rank : 259)
Query Neighborhood Hits	1103	Target Neighborhood Hits	308	Shared Neighborhood Hits	240
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

LATS2_HUMAN
NC score	0.393676 (rank : 867)	θ value	θ > 10 (rank : 1449)
Query Neighborhood Hits	1103	Target Neighborhood Hits	884	Shared Neighborhood Hits	558
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

ASB4_HUMAN
NC score	0.393092 (rank : 868)	θ value	0.00035302 (rank : 331)
Query Neighborhood Hits	1103	Target Neighborhood Hits	264	Shared Neighborhood Hits	228
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

LATS2_MOUSE
NC score	0.392994 (rank : 869)	θ value	θ > 10 (rank : 1450)
Query Neighborhood Hits	1103	Target Neighborhood Hits	879	Shared Neighborhood Hits	560
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

ANR35_HUMAN
NC score	0.392948 (rank : 870)	θ value	3.19293e-05 (rank : 239)
Query Neighborhood Hits	1103	Target Neighborhood Hits	784	Shared Neighborhood Hits	300
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

PP16A_HUMAN
NC score	0.392811 (rank : 871)	θ value	0.00134147 (rank : 389)
Query Neighborhood Hits	1103	Target Neighborhood Hits	340	Shared Neighborhood Hits	237
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ANR49_MOUSE
NC score	0.392793 (rank : 872)	θ value	1.38821 (rank : 812)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	236
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

PP16B_HUMAN
NC score	0.392642 (rank : 873)	θ value	0.00228821 (rank : 428)
Query Neighborhood Hits	1103	Target Neighborhood Hits	307	Shared Neighborhood Hits	244
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

ANKR7_HUMAN
NC score	0.392436 (rank : 874)	θ value	0.813845 (rank : 770)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	238
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

OSTF1_HUMAN
NC score	0.392006 (rank : 875)	θ value	0.000461057 (rank : 349)
Query Neighborhood Hits	1103	Target Neighborhood Hits	466	Shared Neighborhood Hits	257
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PP16B_MOUSE
NC score	0.391874 (rank : 876)	θ value	0.00298849 (rank : 442)
Query Neighborhood Hits	1103	Target Neighborhood Hits	302	Shared Neighborhood Hits	247
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

CDN2C_MOUSE
NC score	0.391248 (rank : 877)	θ value	θ > 10 (rank : 1234)
Query Neighborhood Hits	1103	Target Neighborhood Hits	270	Shared Neighborhood Hits	231
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ST38L_MOUSE
NC score	0.391153 (rank : 878)	θ value	θ > 10 (rank : 1704)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	546
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ANR11_HUMAN
NC score	0.391109 (rank : 879)	θ value	2.61198e-07 (rank : 108)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1289	Shared Neighborhood Hits	405
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

MTPN_MOUSE
NC score	0.390220 (rank : 880)	θ value	1.81305 (rank : 865)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	228
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

ASB5_HUMAN
NC score	0.390213 (rank : 881)	θ value	0.0330416 (rank : 573)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	235
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ANR41_HUMAN
NC score	0.389917 (rank : 882)	θ value	0.000158464 (rank : 296)
Query Neighborhood Hits	1103	Target Neighborhood Hits	332	Shared Neighborhood Hits	223
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ASB16_HUMAN
NC score	0.389850 (rank : 883)	θ value	0.0330416 (rank : 572)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	237
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ACBD6_MOUSE
NC score	0.389621 (rank : 884)	θ value	0.00509761 (rank : 460)
Query Neighborhood Hits	1103	Target Neighborhood Hits	305	Shared Neighborhood Hits	239
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

IKBE_HUMAN
NC score	0.389437 (rank : 885)	θ value	4.1701e-05 (rank : 246)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	235
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

CDN2C_HUMAN
NC score	0.389311 (rank : 886)	θ value	θ > 10 (rank : 1233)
Query Neighborhood Hits	1103	Target Neighborhood Hits	262	Shared Neighborhood Hits	230
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

MTPN_HUMAN
NC score	0.389165 (rank : 887)	θ value	1.81305 (rank : 864)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	228
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

AN36B_HUMAN
NC score	0.389114 (rank : 888)	θ value	0.0193708 (rank : 531)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	238
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ASB5_MOUSE
NC score	0.388480 (rank : 889)	θ value	0.0252991 (rank : 552)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ASB9_MOUSE
NC score	0.388351 (rank : 890)	θ value	0.0961366 (rank : 631)
Query Neighborhood Hits	1103	Target Neighborhood Hits	257	Shared Neighborhood Hits	224
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

ANR46_HUMAN
NC score	0.388113 (rank : 891)	θ value	0.62314 (rank : 754)
Query Neighborhood Hits	1103	Target Neighborhood Hits	281	Shared Neighborhood Hits	237
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

CSK21_MOUSE
NC score	0.387516 (rank : 892)	θ value	θ > 10 (rank : 1294)
Query Neighborhood Hits	1103	Target Neighborhood Hits	770	Shared Neighborhood Hits	509
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

ACBD6_HUMAN
NC score	0.386990 (rank : 893)	θ value	0.00298849 (rank : 432)
Query Neighborhood Hits	1103	Target Neighborhood Hits	304	Shared Neighborhood Hits	237
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

MIB2_MOUSE
NC score	0.386765 (rank : 894)	θ value	0.000461057 (rank : 348)
Query Neighborhood Hits	1103	Target Neighborhood Hits	409	Shared Neighborhood Hits	239
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

CSK21_HUMAN
NC score	0.386748 (rank : 895)	θ value	θ > 10 (rank : 1293)
Query Neighborhood Hits	1103	Target Neighborhood Hits	772	Shared Neighborhood Hits	509
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

POTE8_HUMAN
NC score	0.386376 (rank : 896)	θ value	0.000461057 (rank : 350)
Query Neighborhood Hits	1103	Target Neighborhood Hits	337	Shared Neighborhood Hits	249
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

ASB4_MOUSE
NC score	0.386306 (rank : 897)	θ value	0.0113563 (rank : 495)
Query Neighborhood Hits	1103	Target Neighborhood Hits	265	Shared Neighborhood Hits	230
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

MIB2_HUMAN
NC score	0.386097 (rank : 898)	θ value	0.000786445 (rank : 359)
Query Neighborhood Hits	1103	Target Neighborhood Hits	438	Shared Neighborhood Hits	243
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

ASB16_MOUSE
NC score	0.385831 (rank : 899)	θ value	1.81305 (rank : 847)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	241
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

SHAN1_HUMAN
NC score	0.385616 (rank : 900)	θ value	4.1701e-05 (rank : 253)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1041	Shared Neighborhood Hits	330
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ANR19_HUMAN
NC score	0.384533 (rank : 901)	θ value	7.1131e-05 (rank : 265)
Query Neighborhood Hits	1103	Target Neighborhood Hits	276	Shared Neighborhood Hits	234
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

TTBK2_HUMAN
NC score	0.383697 (rank : 902)	θ value	θ > 10 (rank : 1769)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	490
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

IKBA_HUMAN
NC score	0.383154 (rank : 903)	θ value	0.00869519 (rank : 482)
Query Neighborhood Hits	1103	Target Neighborhood Hits	280	Shared Neighborhood Hits	239
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

TTBK2_MOUSE
NC score	0.383028 (rank : 904)	θ value	θ > 10 (rank : 1770)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	481
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

ANR12_HUMAN
NC score	0.380217 (rank : 905)	θ value	1.17247e-07 (rank : 100)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1081	Shared Neighborhood Hits	394
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

ASB12_MOUSE
NC score	0.379851 (rank : 906)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	1103	Target Neighborhood Hits	261	Shared Neighborhood Hits	228
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

POT15_HUMAN
NC score	0.379548 (rank : 907)	θ value	0.000786445 (rank : 360)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	386
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

STK40_MOUSE
NC score	0.379316 (rank : 908)	θ value	θ > 10 (rank : 1721)
Query Neighborhood Hits	1103	Target Neighborhood Hits	751	Shared Neighborhood Hits	496
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK40_HUMAN
NC score	0.379174 (rank : 909)	θ value	θ > 10 (rank : 1720)
Query Neighborhood Hits	1103	Target Neighborhood Hits	751	Shared Neighborhood Hits	496
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

CTTB2_HUMAN
NC score	0.378905 (rank : 910)	θ value	2.21117e-06 (rank : 155)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1061	Shared Neighborhood Hits	357
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

DYRK2_HUMAN
NC score	0.377919 (rank : 911)	θ value	θ > 10 (rank : 1325)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	525
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

EHMT1_HUMAN
NC score	0.377800 (rank : 912)	θ value	0.0148317 (rank : 515)
Query Neighborhood Hits	1103	Target Neighborhood Hits	417	Shared Neighborhood Hits	262
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

IKBA_MOUSE
NC score	0.377770 (rank : 913)	θ value	0.0330416 (rank : 577)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

NRBP_HUMAN
NC score	0.377333 (rank : 914)	θ value	θ > 10 (rank : 1531)
Query Neighborhood Hits	1103	Target Neighborhood Hits	448	Shared Neighborhood Hits	328
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
NC score	0.376165 (rank : 915)	θ value	θ > 10 (rank : 1532)
Query Neighborhood Hits	1103	Target Neighborhood Hits	442	Shared Neighborhood Hits	319
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

BARD1_MOUSE
NC score	0.375909 (rank : 916)	θ value	0.0193708 (rank : 532)
Query Neighborhood Hits	1103	Target Neighborhood Hits	411	Shared Neighborhood Hits	244
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

DYR1B_MOUSE
NC score	0.375683 (rank : 917)	θ value	θ > 10 (rank : 1324)
Query Neighborhood Hits	1103	Target Neighborhood Hits	799	Shared Neighborhood Hits	524
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYR1B_HUMAN
NC score	0.375545 (rank : 918)	θ value	θ > 10 (rank : 1323)
Query Neighborhood Hits	1103	Target Neighborhood Hits	831	Shared Neighborhood Hits	526
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

ANKY2_HUMAN
NC score	0.375404 (rank : 919)	θ value	0.00175202 (rank : 395)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	229
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR21_HUMAN
NC score	0.374931 (rank : 920)	θ value	0.00665767 (rank : 470)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	383
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

BARD1_HUMAN
NC score	0.374562 (rank : 921)	θ value	0.0252991 (rank : 553)
Query Neighborhood Hits	1103	Target Neighborhood Hits	427	Shared Neighborhood Hits	245
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

KC1D_HUMAN
NC score	0.374180 (rank : 922)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	1103	Target Neighborhood Hits	737	Shared Neighborhood Hits	492
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.374167 (rank : 923)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	1103	Target Neighborhood Hits	737	Shared Neighborhood Hits	492
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

TITIN_HUMAN
NC score	0.372602 (rank : 924)	θ value	1.81305 (rank : 876)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2923	Shared Neighborhood Hits	690
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

USH1G_MOUSE
NC score	0.372578 (rank : 925)	θ value	0.0113563 (rank : 509)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	228
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

USH1G_HUMAN
NC score	0.372443 (rank : 926)	θ value	0.0113563 (rank : 508)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	228
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

EHMT2_HUMAN
NC score	0.368562 (rank : 927)	θ value	0.125558 (rank : 654)
Query Neighborhood Hits	1103	Target Neighborhood Hits	498	Shared Neighborhood Hits	266
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

CSK22_MOUSE
NC score	0.368420 (rank : 928)	θ value	θ > 10 (rank : 1296)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	501
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

ANFY1_HUMAN
NC score	0.368312 (rank : 929)	θ value	1.87187e-05 (rank : 210)
Query Neighborhood Hits	1103	Target Neighborhood Hits	480	Shared Neighborhood Hits	247
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANR22_HUMAN
NC score	0.368207 (rank : 930)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	1103	Target Neighborhood Hits	243	Shared Neighborhood Hits	215
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANS4B_HUMAN
NC score	0.368047 (rank : 931)	θ value	0.0431538 (rank : 589)
Query Neighborhood Hits	1103	Target Neighborhood Hits	289	Shared Neighborhood Hits	228
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANKY2_MOUSE
NC score	0.367900 (rank : 932)	θ value	0.000461057 (rank : 344)
Query Neighborhood Hits	1103	Target Neighborhood Hits	316	Shared Neighborhood Hits	236
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ZDH17_HUMAN
NC score	0.367781 (rank : 933)	θ value	2.44474e-05 (rank : 235)
Query Neighborhood Hits	1103	Target Neighborhood Hits	334	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

IKBB_MOUSE
NC score	0.367518 (rank : 934)	θ value	0.279714 (rank : 701)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	238
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

KC1E_MOUSE
NC score	0.367226 (rank : 935)	θ value	θ > 10 (rank : 1422)
Query Neighborhood Hits	1103	Target Neighborhood Hits	728	Shared Neighborhood Hits	490
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_HUMAN
NC score	0.367200 (rank : 936)	θ value	θ > 10 (rank : 1421)
Query Neighborhood Hits	1103	Target Neighborhood Hits	732	Shared Neighborhood Hits	490
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

CSK22_HUMAN
NC score	0.367192 (rank : 937)	θ value	θ > 10 (rank : 1295)
Query Neighborhood Hits	1103	Target Neighborhood Hits	758	Shared Neighborhood Hits	501
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

ANFY1_MOUSE
NC score	0.366219 (rank : 938)	θ value	0.000121331 (rank : 285)
Query Neighborhood Hits	1103	Target Neighborhood Hits	480	Shared Neighborhood Hits	247
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

AN36A_HUMAN
NC score	0.366008 (rank : 939)	θ value	5.27518 (rank : 981)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	234
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ZDH17_MOUSE
NC score	0.365785 (rank : 940)	θ value	2.44474e-05 (rank : 236)
Query Neighborhood Hits	1103	Target Neighborhood Hits	328	Shared Neighborhood Hits	236
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

EHMT2_MOUSE
NC score	0.364782 (rank : 941)	θ value	0.0431538 (rank : 591)
Query Neighborhood Hits	1103	Target Neighborhood Hits	750	Shared Neighborhood Hits	299
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

DYR1A_HUMAN
NC score	0.363866 (rank : 942)	θ value	θ > 10 (rank : 1321)
Query Neighborhood Hits	1103	Target Neighborhood Hits	764	Shared Neighborhood Hits	509
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.363864 (rank : 943)	θ value	θ > 10 (rank : 1322)
Query Neighborhood Hits	1103	Target Neighborhood Hits	762	Shared Neighborhood Hits	509
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

ANS4B_MOUSE
NC score	0.363410 (rank : 944)	θ value	0.0961366 (rank : 630)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	229
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

IKBB_HUMAN
NC score	0.363333 (rank : 945)	θ value	1.06291 (rank : 790)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	237
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

CLK4_HUMAN
NC score	0.359725 (rank : 946)	θ value	θ > 10 (rank : 1263)
Query Neighborhood Hits	1103	Target Neighborhood Hits	759	Shared Neighborhood Hits	508
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
NC score	0.359663 (rank : 947)	θ value	θ > 10 (rank : 1264)
Query Neighborhood Hits	1103	Target Neighborhood Hits	759	Shared Neighborhood Hits	508
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

ZDH13_MOUSE
NC score	0.359203 (rank : 948)	θ value	0.00298849 (rank : 446)
Query Neighborhood Hits	1103	Target Neighborhood Hits	329	Shared Neighborhood Hits	237
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

ZDH13_HUMAN
NC score	0.358862 (rank : 949)	θ value	0.0330416 (rank : 587)
Query Neighborhood Hits	1103	Target Neighborhood Hits	322	Shared Neighborhood Hits	235
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

SCYL2_HUMAN
NC score	0.357270 (rank : 950)	θ value	0.365318 (rank : 732)
Query Neighborhood Hits	1103	Target Neighborhood Hits	632	Shared Neighborhood Hits	438
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

CLK1_MOUSE
NC score	0.356480 (rank : 951)	θ value	θ > 10 (rank : 1258)
Query Neighborhood Hits	1103	Target Neighborhood Hits	760	Shared Neighborhood Hits	501
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

ASB6_HUMAN
NC score	0.355815 (rank : 952)	θ value	0.21417 (rank : 680)
Query Neighborhood Hits	1103	Target Neighborhood Hits	256	Shared Neighborhood Hits	225
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

CD2A1_MOUSE
NC score	0.355607 (rank : 953)	θ value	0.000602161 (rank : 354)
Query Neighborhood Hits	1103	Target Neighborhood Hits	206	Shared Neighborhood Hits	188
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

A20A3_HUMAN
NC score	0.355371 (rank : 954)	θ value	2.44474e-05 (rank : 225)
Query Neighborhood Hits	1103	Target Neighborhood Hits	692	Shared Neighborhood Hits	310
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A2_HUMAN
NC score	0.354595 (rank : 955)	θ value	2.44474e-05 (rank : 224)
Query Neighborhood Hits	1103	Target Neighborhood Hits	716	Shared Neighborhood Hits	312
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A1_HUMAN
NC score	0.354463 (rank : 956)	θ value	2.44474e-05 (rank : 223)
Query Neighborhood Hits	1103	Target Neighborhood Hits	698	Shared Neighborhood Hits	310
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

MPP8_HUMAN
NC score	0.354338 (rank : 957)	θ value	0.00134147 (rank : 388)
Query Neighborhood Hits	1103	Target Neighborhood Hits	948	Shared Neighborhood Hits	383
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

CLK1_HUMAN
NC score	0.353581 (rank : 958)	θ value	θ > 10 (rank : 1257)
Query Neighborhood Hits	1103	Target Neighborhood Hits	756	Shared Neighborhood Hits	498
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

A20A4_HUMAN
NC score	0.353445 (rank : 959)	θ value	2.44474e-05 (rank : 226)
Query Neighborhood Hits	1103	Target Neighborhood Hits	710	Shared Neighborhood Hits	310
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

ASB6_MOUSE
NC score	0.353440 (rank : 960)	θ value	0.365318 (rank : 712)
Query Neighborhood Hits	1103	Target Neighborhood Hits	264	Shared Neighborhood Hits	221
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

CLPB_MOUSE
NC score	0.352963 (rank : 961)	θ value	1.09739e-05 (rank : 194)
Query Neighborhood Hits	1103	Target Neighborhood Hits	289	Shared Neighborhood Hits	216
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

DYRK4_HUMAN
NC score	0.352062 (rank : 962)	θ value	θ > 10 (rank : 1327)
Query Neighborhood Hits	1103	Target Neighborhood Hits	750	Shared Neighborhood Hits	503
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

POT14_HUMAN
NC score	0.351853 (rank : 963)	θ value	0.21417 (rank : 693)
Query Neighborhood Hits	1103	Target Neighborhood Hits	403	Shared Neighborhood Hits	277
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

ANR37_HUMAN
NC score	0.348072 (rank : 964)	θ value	0.163984 (rank : 662)
Query Neighborhood Hits	1103	Target Neighborhood Hits	247	Shared Neighborhood Hits	222
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

SCYL2_MOUSE
NC score	0.347323 (rank : 965)	θ value	0.21417 (rank : 695)
Query Neighborhood Hits	1103	Target Neighborhood Hits	603	Shared Neighborhood Hits	413
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TRIB2_HUMAN
NC score	0.344829 (rank : 966)	θ value	θ > 10 (rank : 1746)
Query Neighborhood Hits	1103	Target Neighborhood Hits	657	Shared Neighborhood Hits	463
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.343277 (rank : 967)	θ value	θ > 10 (rank : 1747)
Query Neighborhood Hits	1103	Target Neighborhood Hits	653	Shared Neighborhood Hits	460
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

KC1AL_HUMAN
NC score	0.343230 (rank : 968)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	1103	Target Neighborhood Hits	734	Shared Neighborhood Hits	490
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1A_HUMAN
NC score	0.341850 (rank : 969)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	1103	Target Neighborhood Hits	728	Shared Neighborhood Hits	494
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.341850 (rank : 970)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	1103	Target Neighborhood Hits	728	Shared Neighborhood Hits	494
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

CLK2_HUMAN
NC score	0.340898 (rank : 971)	θ value	θ > 10 (rank : 1259)
Query Neighborhood Hits	1103	Target Neighborhood Hits	752	Shared Neighborhood Hits	496
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

ANR15_HUMAN
NC score	0.340783 (rank : 972)	θ value	0.0736092 (rank : 618)
Query Neighborhood Hits	1103	Target Neighborhood Hits	478	Shared Neighborhood Hits	273
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANR47_MOUSE
NC score	0.340611 (rank : 973)	θ value	0.125558 (rank : 649)
Query Neighborhood Hits	1103	Target Neighborhood Hits	350	Shared Neighborhood Hits	244
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

BCOR_MOUSE
NC score	0.339667 (rank : 974)	θ value	0.163984 (rank : 665)
Query Neighborhood Hits	1103	Target Neighborhood Hits	521	Shared Neighborhood Hits	276
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

SNCAP_HUMAN
NC score	0.338621 (rank : 975)	θ value	4.03905 (rank : 974)
Query Neighborhood Hits	1103	Target Neighborhood Hits	313	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

NFKB2_HUMAN
NC score	0.337774 (rank : 976)	θ value	0.365318 (rank : 729)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	240
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

BCOR_HUMAN
NC score	0.336963 (rank : 977)	θ value	0.163984 (rank : 664)
Query Neighborhood Hits	1103	Target Neighborhood Hits	609	Shared Neighborhood Hits	291
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CLK3_HUMAN
NC score	0.335961 (rank : 978)	θ value	θ > 10 (rank : 1261)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	494
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.335734 (rank : 979)	θ value	θ > 10 (rank : 1262)
Query Neighborhood Hits	1103	Target Neighborhood Hits	761	Shared Neighborhood Hits	495
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

NFKB1_HUMAN
NC score	0.335023 (rank : 980)	θ value	0.0148317 (rank : 527)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	236
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NFKB2_MOUSE
NC score	0.334639 (rank : 981)	θ value	0.0252991 (rank : 562)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	240
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR37_MOUSE
NC score	0.334579 (rank : 982)	θ value	1.38821 (rank : 810)
Query Neighborhood Hits	1103	Target Neighborhood Hits	237	Shared Neighborhood Hits	213
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR32_HUMAN
NC score	0.334114 (rank : 983)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	1103	Target Neighborhood Hits	270	Shared Neighborhood Hits	222
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

KC1G1_MOUSE
NC score	0.333977 (rank : 984)	θ value	θ > 10 (rank : 1424)
Query Neighborhood Hits	1103	Target Neighborhood Hits	713	Shared Neighborhood Hits	474
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_HUMAN
NC score	0.333631 (rank : 985)	θ value	θ > 10 (rank : 1423)
Query Neighborhood Hits	1103	Target Neighborhood Hits	708	Shared Neighborhood Hits	472
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

MKNK1_HUMAN
NC score	0.333111 (rank : 986)	θ value	θ > 10 (rank : 1481)
Query Neighborhood Hits	1103	Target Neighborhood Hits	701	Shared Neighborhood Hits	440
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

NFKB1_MOUSE
NC score	0.332572 (rank : 987)	θ value	1.81305 (rank : 870)
Query Neighborhood Hits	1103	Target Neighborhood Hits	300	Shared Neighborhood Hits	234
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

RAI14_HUMAN
NC score	0.332087 (rank : 988)	θ value	4.45536e-07 (rank : 121)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1367	Shared Neighborhood Hits	372
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

KC1G3_HUMAN
NC score	0.331343 (rank : 989)	θ value	θ > 10 (rank : 1425)
Query Neighborhood Hits	1103	Target Neighborhood Hits	711	Shared Neighborhood Hits	475
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

CLK2_MOUSE
NC score	0.330795 (rank : 990)	θ value	θ > 10 (rank : 1260)
Query Neighborhood Hits	1103	Target Neighborhood Hits	743	Shared Neighborhood Hits	491
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

OSBL1_HUMAN
NC score	0.328023 (rank : 991)	θ value	1.43324e-05 (rank : 204)
Query Neighborhood Hits	1103	Target Neighborhood Hits	368	Shared Neighborhood Hits	249
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ANR32_MOUSE
NC score	0.327146 (rank : 992)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	222
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

RAI14_MOUSE
NC score	0.324185 (rank : 993)	θ value	1.69304e-06 (rank : 152)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1505	Shared Neighborhood Hits	411
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANR18_HUMAN
NC score	0.323940 (rank : 994)	θ value	0.00134147 (rank : 374)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1106	Shared Neighborhood Hits	347
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR47_HUMAN
NC score	0.323347 (rank : 995)	θ value	1.38821 (rank : 811)
Query Neighborhood Hits	1103	Target Neighborhood Hits	369	Shared Neighborhood Hits	238
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

OSBL1_MOUSE
NC score	0.322139 (rank : 996)	θ value	1.43324e-05 (rank : 205)
Query Neighborhood Hits	1103	Target Neighborhood Hits	336	Shared Neighborhood Hits	238
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

AN30A_HUMAN
NC score	0.322032 (rank : 997)	θ value	9.29e-05 (rank : 276)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1119	Shared Neighborhood Hits	390
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

IASPP_HUMAN
NC score	0.320116 (rank : 998)	θ value	1.81305 (rank : 857)
Query Neighborhood Hits	1103	Target Neighborhood Hits	688	Shared Neighborhood Hits	292
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

POT22_HUMAN
NC score	0.319716 (rank : 999)	θ value	5.27518 (rank : 1009)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	224
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

ASPP2_HUMAN
NC score	0.319498 (rank : 1000)	θ value	0.0148317 (rank : 513)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1156	Shared Neighborhood Hits	371
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

RPKL1_HUMAN
NC score	0.318676 (rank : 1001)	θ value	θ > 10 (rank : 1625)
Query Neighborhood Hits	1103	Target Neighborhood Hits	708	Shared Neighborhood Hits	459
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
NC score	0.317271 (rank : 1002)	θ value	θ > 10 (rank : 1626)
Query Neighborhood Hits	1103	Target Neighborhood Hits	704	Shared Neighborhood Hits	462
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

KC1G2_HUMAN
NC score	0.315469 (rank : 1003)	θ value	8.99809 (rank : 1077)
Query Neighborhood Hits	1103	Target Neighborhood Hits	693	Shared Neighborhood Hits	464
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

ANR25_HUMAN
NC score	0.314746 (rank : 1004)	θ value	0.365318 (rank : 710)
Query Neighborhood Hits	1103	Target Neighborhood Hits	350	Shared Neighborhood Hits	233
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ANR25_MOUSE
NC score	0.313877 (rank : 1005)	θ value	0.0431538 (rank : 588)
Query Neighborhood Hits	1103	Target Neighborhood Hits	398	Shared Neighborhood Hits	242
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ASPP1_HUMAN
NC score	0.313242 (rank : 1006)	θ value	0.0736092 (rank : 620)
Query Neighborhood Hits	1103	Target Neighborhood Hits	956	Shared Neighborhood Hits	347
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CLPB_HUMAN
NC score	0.312978 (rank : 1007)	θ value	0.00175202 (rank : 401)
Query Neighborhood Hits	1103	Target Neighborhood Hits	265	Shared Neighborhood Hits	203
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

KC1G2_MOUSE
NC score	0.311409 (rank : 1008)	θ value	6.88961 (rank : 1034)
Query Neighborhood Hits	1103	Target Neighborhood Hits	695	Shared Neighborhood Hits	464
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

ANR33_MOUSE
NC score	0.309104 (rank : 1009)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	200
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

KRIT1_MOUSE
NC score	0.306582 (rank : 1010)	θ value	θ > 10 (rank : 1438)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	206
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

ASPP1_MOUSE
NC score	0.305834 (rank : 1011)	θ value	0.0736092 (rank : 621)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1244	Shared Neighborhood Hits	390
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ANR33_HUMAN
NC score	0.304419 (rank : 1012)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	1103	Target Neighborhood Hits	215	Shared Neighborhood Hits	194
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

TRIB1_MOUSE
NC score	0.301169 (rank : 1013)	θ value	θ > 10 (rank : 1745)
Query Neighborhood Hits	1103	Target Neighborhood Hits	593	Shared Neighborhood Hits	397
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

HECD1_HUMAN
NC score	0.299707 (rank : 1014)	θ value	0.00298849 (rank : 437)
Query Neighborhood Hits	1103	Target Neighborhood Hits	371	Shared Neighborhood Hits	238
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

TRIB1_HUMAN
NC score	0.299701 (rank : 1015)	θ value	θ > 10 (rank : 1744)
Query Neighborhood Hits	1103	Target Neighborhood Hits	598	Shared Neighborhood Hits	393
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

ANR38_HUMAN
NC score	0.297784 (rank : 1016)	θ value	5.27518 (rank : 982)
Query Neighborhood Hits	1103	Target Neighborhood Hits	443	Shared Neighborhood Hits	249
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

CDN2B_MOUSE
NC score	0.296784 (rank : 1017)	θ value	θ > 10 (rank : 1232)
Query Neighborhood Hits	1103	Target Neighborhood Hits	201	Shared Neighborhood Hits	186
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

ANR45_MOUSE
NC score	0.294766 (rank : 1018)	θ value	0.365318 (rank : 711)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	176
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

TRIB3_MOUSE
NC score	0.294697 (rank : 1019)	θ value	θ > 10 (rank : 1749)
Query Neighborhood Hits	1103	Target Neighborhood Hits	578	Shared Neighborhood Hits	385
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

KRIT1_HUMAN
NC score	0.290392 (rank : 1020)	θ value	θ > 10 (rank : 1437)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	199
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

IASPP_MOUSE
NC score	0.288616 (rank : 1021)	θ value	5.27518 (rank : 992)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1024	Shared Neighborhood Hits	325
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CDC7_HUMAN
NC score	0.287784 (rank : 1022)	θ value	θ > 10 (rank : 1212)
Query Neighborhood Hits	1103	Target Neighborhood Hits	652	Shared Neighborhood Hits	398
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

KS6C1_MOUSE
NC score	0.287022 (rank : 1023)	θ value	θ > 10 (rank : 1440)
Query Neighborhood Hits	1103	Target Neighborhood Hits	700	Shared Neighborhood Hits	421
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

ANR38_MOUSE
NC score	0.286089 (rank : 1024)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	1103	Target Neighborhood Hits	512	Shared Neighborhood Hits	264
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

CDN2B_HUMAN
NC score	0.282460 (rank : 1025)	θ value	θ > 10 (rank : 1231)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	184
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

ANR45_HUMAN
NC score	0.281860 (rank : 1026)	θ value	0.279714 (rank : 696)
Query Neighborhood Hits	1103	Target Neighborhood Hits	201	Shared Neighborhood Hits	171
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANR40_HUMAN
NC score	0.281316 (rank : 1027)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	1103	Target Neighborhood Hits	224	Shared Neighborhood Hits	189
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

GIT2_MOUSE
NC score	0.281195 (rank : 1028)	θ value	0.00035302 (rank : 335)
Query Neighborhood Hits	1103	Target Neighborhood Hits	323	Shared Neighborhood Hits	236
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

KS6C1_HUMAN
NC score	0.280381 (rank : 1029)	θ value	θ > 10 (rank : 1439)
Query Neighborhood Hits	1103	Target Neighborhood Hits	682	Shared Neighborhood Hits	417
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

CD2A1_HUMAN
NC score	0.279859 (rank : 1030)	θ value	θ > 10 (rank : 1205)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	177
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

UACA_HUMAN
NC score	0.278806 (rank : 1031)	θ value	7.1131e-05 (rank : 275)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1622	Shared Neighborhood Hits	395
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

GIT1_MOUSE
NC score	0.278433 (rank : 1032)	θ value	5.44631e-05 (rank : 258)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	241
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

TRIB3_HUMAN
NC score	0.277776 (rank : 1033)	θ value	θ > 10 (rank : 1748)
Query Neighborhood Hits	1103	Target Neighborhood Hits	519	Shared Neighborhood Hits	335
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

GIT1_HUMAN
NC score	0.277643 (rank : 1034)	θ value	5.44631e-05 (rank : 257)
Query Neighborhood Hits	1103	Target Neighborhood Hits	336	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

ANR40_MOUSE
NC score	0.277342 (rank : 1035)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	193
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

CDC7_MOUSE
NC score	0.273744 (rank : 1036)	θ value	θ > 10 (rank : 1213)
Query Neighborhood Hits	1103	Target Neighborhood Hits	641	Shared Neighborhood Hits	394
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

ANR43_HUMAN
NC score	0.271500 (rank : 1037)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	1103	Target Neighborhood Hits	209	Shared Neighborhood Hits	184
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR43_MOUSE
NC score	0.269990 (rank : 1038)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	1103	Target Neighborhood Hits	214	Shared Neighborhood Hits	191
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

UACA_MOUSE
NC score	0.268671 (rank : 1039)	θ value	0.000121331 (rank : 294)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1620	Shared Neighborhood Hits	407
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

ANR26_MOUSE
NC score	0.266087 (rank : 1040)	θ value	9.92553e-07 (rank : 133)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1554	Shared Neighborhood Hits	407
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANKY1_HUMAN
NC score	0.265084 (rank : 1041)	θ value	1.38821 (rank : 809)
Query Neighborhood Hits	1103	Target Neighborhood Hits	248	Shared Neighborhood Hits	190
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

NUD12_MOUSE
NC score	0.263677 (rank : 1042)	θ value	θ > 10 (rank : 1536)
Query Neighborhood Hits	1103	Target Neighborhood Hits	243	Shared Neighborhood Hits	198
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

CENB5_HUMAN
NC score	0.262611 (rank : 1043)	θ value	0.365318 (rank : 714)
Query Neighborhood Hits	1103	Target Neighborhood Hits	395	Shared Neighborhood Hits	242
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

GIT2_HUMAN
NC score	0.262540 (rank : 1044)	θ value	0.00228821 (rank : 420)
Query Neighborhood Hits	1103	Target Neighborhood Hits	381	Shared Neighborhood Hits	243
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

CENB2_HUMAN
NC score	0.262109 (rank : 1045)	θ value	0.0330416 (rank : 574)
Query Neighborhood Hits	1103	Target Neighborhood Hits	425	Shared Neighborhood Hits	238
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

ABTB2_HUMAN
NC score	0.261986 (rank : 1046)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	1103	Target Neighborhood Hits	391	Shared Neighborhood Hits	209
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ASB14_HUMAN
NC score	0.257875 (rank : 1047)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	1103	Target Neighborhood Hits	187	Shared Neighborhood Hits	168
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

CENB1_HUMAN
NC score	0.257324 (rank : 1048)	θ value	1.81305 (rank : 851)
Query Neighborhood Hits	1103	Target Neighborhood Hits	383	Shared Neighborhood Hits	236
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

SLAP2_MOUSE
NC score	0.256516 (rank : 1049)	θ value	θ > 10 (rank : 1674)
Query Neighborhood Hits	1103	Target Neighborhood Hits	136	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ABTB2_MOUSE
NC score	0.255460 (rank : 1050)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	1103	Target Neighborhood Hits	414	Shared Neighborhood Hits	210
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ANR26_HUMAN
NC score	0.254578 (rank : 1051)	θ value	0.00134147 (rank : 375)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1614	Shared Neighborhood Hits	415
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

VRK2_HUMAN
NC score	0.249877 (rank : 1052)	θ value	θ > 10 (rank : 1789)
Query Neighborhood Hits	1103	Target Neighborhood Hits	582	Shared Neighborhood Hits	393
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_MOUSE
NC score	0.249559 (rank : 1053)	θ value	θ > 10 (rank : 1788)
Query Neighborhood Hits	1103	Target Neighborhood Hits	583	Shared Neighborhood Hits	402
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

SLAP2_HUMAN
NC score	0.248641 (rank : 1054)	θ value	θ > 10 (rank : 1673)
Query Neighborhood Hits	1103	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

NUD12_HUMAN
NC score	0.247495 (rank : 1055)	θ value	θ > 10 (rank : 1535)
Query Neighborhood Hits	1103	Target Neighborhood Hits	222	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

SLAP1_HUMAN
NC score	0.247366 (rank : 1056)	θ value	θ > 10 (rank : 1671)
Query Neighborhood Hits	1103	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

TRPV6_MOUSE
NC score	0.246207 (rank : 1057)	θ value	1.38821 (rank : 843)
Query Neighborhood Hits	1103	Target Neighborhood Hits	284	Shared Neighborhood Hits	220
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

SLAP1_MOUSE
NC score	0.244032 (rank : 1058)	θ value	θ > 10 (rank : 1672)
Query Neighborhood Hits	1103	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

VRK2_MOUSE
NC score	0.240196 (rank : 1059)	θ value	θ > 10 (rank : 1790)
Query Neighborhood Hits	1103	Target Neighborhood Hits	586	Shared Neighborhood Hits	394
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_HUMAN
NC score	0.237478 (rank : 1060)	θ value	θ > 10 (rank : 1787)
Query Neighborhood Hits	1103	Target Neighborhood Hits	584	Shared Neighborhood Hits	397
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

STK31_HUMAN
NC score	0.230492 (rank : 1061)	θ value	θ > 10 (rank : 1715)
Query Neighborhood Hits	1103	Target Neighborhood Hits	570	Shared Neighborhood Hits	319
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

BUB1_MOUSE
NC score	0.228385 (rank : 1062)	θ value	θ > 10 (rank : 1188)
Query Neighborhood Hits	1103	Target Neighborhood Hits	583	Shared Neighborhood Hits	347
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

AN13B_MOUSE
NC score	0.228258 (rank : 1063)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	1103	Target Neighborhood Hits	276	Shared Neighborhood Hits	229
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13C_HUMAN
NC score	0.228233 (rank : 1064)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	1103	Target Neighborhood Hits	241	Shared Neighborhood Hits	209
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13B_HUMAN
NC score	0.227241 (rank : 1065)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	1103	Target Neighborhood Hits	265	Shared Neighborhood Hits	226
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13C_MOUSE
NC score	0.222408 (rank : 1066)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	1103	Target Neighborhood Hits	242	Shared Neighborhood Hits	207
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

GLSL_HUMAN
NC score	0.218132 (rank : 1067)	θ value	θ > 10 (rank : 1357)
Query Neighborhood Hits	1103	Target Neighborhood Hits	211	Shared Neighborhood Hits	181
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

NOTC4_MOUSE
NC score	0.216802 (rank : 1068)	θ value	0.00102713 (rank : 368)
Query Neighborhood Hits	1103	Target Neighborhood Hits	872	Shared Neighborhood Hits	259
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

TRPV5_MOUSE
NC score	0.215078 (rank : 1069)	θ value	θ > 10 (rank : 1758)
Query Neighborhood Hits	1103	Target Neighborhood Hits	278	Shared Neighborhood Hits	218
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

SRPK2_MOUSE
NC score	0.213850 (rank : 1070)	θ value	6.88961 (rank : 1053)
Query Neighborhood Hits	1103	Target Neighborhood Hits	765	Shared Neighborhood Hits	404
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

NOTC4_HUMAN
NC score	0.213117 (rank : 1071)	θ value	0.00175202 (rank : 409)
Query Neighborhood Hits	1103	Target Neighborhood Hits	905	Shared Neighborhood Hits	260
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

CT012_MOUSE
NC score	0.212291 (rank : 1072)	θ value	θ > 10 (rank : 1298)
Query Neighborhood Hits	1103	Target Neighborhood Hits	229	Shared Neighborhood Hits	171
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

SRPK1_HUMAN
NC score	0.211971 (rank : 1073)	θ value	θ > 10 (rank : 1695)
Query Neighborhood Hits	1103	Target Neighborhood Hits	706	Shared Neighborhood Hits	396
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

GLSL_MOUSE
NC score	0.211659 (rank : 1074)	θ value	θ > 10 (rank : 1358)
Query Neighborhood Hits	1103	Target Neighborhood Hits	212	Shared Neighborhood Hits	178
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

SRPK2_HUMAN
NC score	0.211379 (rank : 1075)	θ value	8.99809 (rank : 1092)
Query Neighborhood Hits	1103	Target Neighborhood Hits	664	Shared Neighborhood Hits	391
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK1_MOUSE
NC score	0.209945 (rank : 1076)	θ value	θ > 10 (rank : 1696)
Query Neighborhood Hits	1103	Target Neighborhood Hits	639	Shared Neighborhood Hits	377
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

STK23_MOUSE
NC score	0.208362 (rank : 1077)	θ value	θ > 10 (rank : 1714)
Query Neighborhood Hits	1103	Target Neighborhood Hits	572	Shared Neighborhood Hits	358
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

AN13A_HUMAN
NC score	0.208019 (rank : 1078)	θ value	0.813845 (rank : 769)
Query Neighborhood Hits	1103	Target Neighborhood Hits	243	Shared Neighborhood Hits	196
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

STK23_HUMAN
NC score	0.206419 (rank : 1079)	θ value	θ > 10 (rank : 1713)
Query Neighborhood Hits	1103	Target Neighborhood Hits	556	Shared Neighborhood Hits	352
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

GLSK_HUMAN
NC score	0.205548 (rank : 1080)	θ value	θ > 10 (rank : 1356)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	170
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

TRPV5_HUMAN
NC score	0.201057 (rank : 1081)	θ value	θ > 10 (rank : 1757)
Query Neighborhood Hits	1103	Target Neighborhood Hits	261	Shared Neighborhood Hits	199
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

GRAP_MOUSE
NC score	0.200316 (rank : 1082)	θ value	θ > 10 (rank : 1369)
Query Neighborhood Hits	1103	Target Neighborhood Hits	309	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

DDFL1_MOUSE
NC score	0.199954 (rank : 1083)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	227
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

GRAP_HUMAN
NC score	0.199623 (rank : 1084)	θ value	θ > 10 (rank : 1368)
Query Neighborhood Hits	1103	Target Neighborhood Hits	307	Shared Neighborhood Hits	68
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

DGKZ_HUMAN
NC score	0.199422 (rank : 1085)	θ value	0.00665767 (rank : 472)
Query Neighborhood Hits	1103	Target Neighborhood Hits	551	Shared Neighborhood Hits	205
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

TRPV6_HUMAN
NC score	0.199125 (rank : 1086)	θ value	θ > 10 (rank : 1759)
Query Neighborhood Hits	1103	Target Neighborhood Hits	262	Shared Neighborhood Hits	195
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

NTKL_MOUSE
NC score	0.198094 (rank : 1087)	θ value	1.81305 (rank : 872)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	217
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

STK31_MOUSE
NC score	0.195992 (rank : 1088)	θ value	θ > 10 (rank : 1716)
Query Neighborhood Hits	1103	Target Neighborhood Hits	474	Shared Neighborhood Hits	268
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

NOTC3_HUMAN
NC score	0.195477 (rank : 1089)	θ value	0.00175202 (rank : 407)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1062	Shared Neighborhood Hits	271
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
NC score	0.194554 (rank : 1090)	θ value	0.00175202 (rank : 408)
Query Neighborhood Hits	1103	Target Neighborhood Hits	975	Shared Neighborhood Hits	258
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

GRAP2_HUMAN
NC score	0.194351 (rank : 1091)	θ value	θ > 10 (rank : 1366)
Query Neighborhood Hits	1103	Target Neighborhood Hits	304	Shared Neighborhood Hits	63
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NOTC2_HUMAN
NC score	0.193899 (rank : 1092)	θ value	0.00665767 (rank : 478)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1113	Shared Neighborhood Hits	294
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

GRB2_HUMAN
NC score	0.192833 (rank : 1093)	θ value	θ > 10 (rank : 1374)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	64
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.192712 (rank : 1094)	θ value	θ > 10 (rank : 1375)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	64
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP2_MOUSE
NC score	0.191745 (rank : 1095)	θ value	θ > 10 (rank : 1367)
Query Neighborhood Hits	1103	Target Neighborhood Hits	297	Shared Neighborhood Hits	61
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NOTC1_HUMAN
NC score	0.190953 (rank : 1096)	θ value	0.0148317 (rank : 528)
Query Neighborhood Hits	1103	Target Neighborhood Hits	906	Shared Neighborhood Hits	262
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

DGKZ_MOUSE
NC score	0.190513 (rank : 1097)	θ value	0.0330416 (rank : 575)
Query Neighborhood Hits	1103	Target Neighborhood Hits	542	Shared Neighborhood Hits	194
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKI_HUMAN
NC score	0.189841 (rank : 1098)	θ value	0.0148317 (rank : 514)
Query Neighborhood Hits	1103	Target Neighborhood Hits	609	Shared Neighborhood Hits	200
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

AN13A_MOUSE
NC score	0.188935 (rank : 1099)	θ value	4.03905 (rank : 948)
Query Neighborhood Hits	1103	Target Neighborhood Hits	226	Shared Neighborhood Hits	193
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

NOTC2_MOUSE
NC score	0.187988 (rank : 1100)	θ value	0.0330416 (rank : 581)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1069	Shared Neighborhood Hits	266
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

CT012_HUMAN
NC score	0.185478 (rank : 1101)	θ value	θ > 10 (rank : 1297)
Query Neighborhood Hits	1103	Target Neighborhood Hits	205	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

NCK1_HUMAN
NC score	0.185478 (rank : 1102)	θ value	θ > 10 (rank : 1517)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	62
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ANKZ1_MOUSE
NC score	0.184900 (rank : 1103)	θ value	0.163984 (rank : 661)
Query Neighborhood Hits	1103	Target Neighborhood Hits	208	Shared Neighborhood Hits	145
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

NCK2_HUMAN
NC score	0.184671 (rank : 1104)	θ value	θ > 10 (rank : 1518)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	66
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ANKZ1_HUMAN
NC score	0.182780 (rank : 1105)	θ value	0.21417 (rank : 678)
Query Neighborhood Hits	1103	Target Neighborhood Hits	236	Shared Neighborhood Hits	158
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

SH21B_MOUSE
NC score	0.180367 (rank : 1106)	θ value	θ > 10 (rank : 1646)
Query Neighborhood Hits	1103	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

DDEF2_HUMAN
NC score	0.177880 (rank : 1107)	θ value	θ > 10 (rank : 1309)
Query Neighborhood Hits	1103	Target Neighborhood Hits	599	Shared Neighborhood Hits	250
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.177347 (rank : 1108)	θ value	θ > 10 (rank : 1310)
Query Neighborhood Hits	1103	Target Neighborhood Hits	625	Shared Neighborhood Hits	260
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

IKBL_HUMAN
NC score	0.169806 (rank : 1109)	θ value	1.81305 (rank : 858)
Query Neighborhood Hits	1103	Target Neighborhood Hits	168	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

CENG2_HUMAN
NC score	0.168925 (rank : 1110)	θ value	0.365318 (rank : 715)
Query Neighborhood Hits	1103	Target Neighborhood Hits	471	Shared Neighborhood Hits	231
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG1_MOUSE
NC score	0.168795 (rank : 1111)	θ value	6.88961 (rank : 1027)
Query Neighborhood Hits	1103	Target Neighborhood Hits	531	Shared Neighborhood Hits	233
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

IKBL_MOUSE
NC score	0.168013 (rank : 1112)	θ value	3.0926 (rank : 916)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	154
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

CENG2_MOUSE
NC score	0.167315 (rank : 1113)	θ value	0.62314 (rank : 757)
Query Neighborhood Hits	1103	Target Neighborhood Hits	463	Shared Neighborhood Hits	227
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG1_HUMAN
NC score	0.166410 (rank : 1114)	θ value	6.88961 (rank : 1026)
Query Neighborhood Hits	1103	Target Neighborhood Hits	544	Shared Neighborhood Hits	231
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

SH21A_MOUSE
NC score	0.164507 (rank : 1115)	θ value	θ > 10 (rank : 1644)
Query Neighborhood Hits	1103	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
NC score	0.162465 (rank : 1116)	θ value	θ > 10 (rank : 1645)
Query Neighborhood Hits	1103	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

DDFL1_HUMAN
NC score	0.160747 (rank : 1117)	θ value	θ > 10 (rank : 1311)
Query Neighborhood Hits	1103	Target Neighborhood Hits	353	Shared Neighborhood Hits	224
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

BUB1_HUMAN
NC score	0.159803 (rank : 1118)	θ value	θ > 10 (rank : 1187)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	275
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

NOTC1_MOUSE
NC score	0.158793 (rank : 1119)	θ value	0.47712 (rank : 748)
Query Neighborhood Hits	1103	Target Neighborhood Hits	916	Shared Neighborhood Hits	248
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

VRK3_MOUSE
NC score	0.156297 (rank : 1120)	θ value	8.99809 (rank : 1100)
Query Neighborhood Hits	1103	Target Neighborhood Hits	342	Shared Neighborhood Hits	247
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

SH21A_HUMAN
NC score	0.154556 (rank : 1121)	θ value	θ > 10 (rank : 1643)
Query Neighborhood Hits	1103	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

CENG3_HUMAN
NC score	0.154048 (rank : 1122)	θ value	1.06291 (rank : 782)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	214
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
NC score	0.153559 (rank : 1123)	θ value	1.06291 (rank : 783)
Query Neighborhood Hits	1103	Target Neighborhood Hits	467	Shared Neighborhood Hits	214
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

NTKL_HUMAN
NC score	0.144798 (rank : 1124)	θ value	8.99809 (rank : 1084)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	170
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

RASA1_HUMAN
NC score	0.139926 (rank : 1125)	θ value	θ > 10 (rank : 1606)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

K2002_HUMAN
NC score	0.139211 (rank : 1126)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	1103	Target Neighborhood Hits	274	Shared Neighborhood Hits	179
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

DDEF1_MOUSE
NC score	0.137318 (rank : 1127)	θ value	θ > 10 (rank : 1308)
Query Neighborhood Hits	1103	Target Neighborhood Hits	592	Shared Neighborhood Hits	227
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CLR59_HUMAN
NC score	0.137073 (rank : 1128)	θ value	θ > 10 (rank : 1265)
Query Neighborhood Hits	1103	Target Neighborhood Hits	163	Shared Neighborhood Hits	134
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

CRKL_MOUSE
NC score	0.136163 (rank : 1129)	θ value	θ > 10 (rank : 1289)
Query Neighborhood Hits	1103	Target Neighborhood Hits	307	Shared Neighborhood Hits	63
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.133462 (rank : 1130)	θ value	θ > 10 (rank : 1288)
Query Neighborhood Hits	1103	Target Neighborhood Hits	313	Shared Neighborhood Hits	63
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

VRK3_HUMAN
NC score	0.132242 (rank : 1131)	θ value	θ > 10 (rank : 1791)
Query Neighborhood Hits	1103	Target Neighborhood Hits	349	Shared Neighborhood Hits	231
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ABTB1_MOUSE
NC score	0.132120 (rank : 1132)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	1103	Target Neighborhood Hits	349	Shared Neighborhood Hits	154
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ANKR9_MOUSE
NC score	0.128501 (rank : 1133)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	1103	Target Neighborhood Hits	120	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

VAV3_HUMAN
NC score	0.127752 (rank : 1134)	θ value	θ > 10 (rank : 1781)
Query Neighborhood Hits	1103	Target Neighborhood Hits	398	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BAT4_MOUSE
NC score	0.127571 (rank : 1135)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	1103	Target Neighborhood Hits	171	Shared Neighborhood Hits	112
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

VAV3_MOUSE
NC score	0.127435 (rank : 1136)	θ value	θ > 10 (rank : 1782)
Query Neighborhood Hits	1103	Target Neighborhood Hits	404	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

DAPP1_HUMAN
NC score	0.126999 (rank : 1137)	θ value	θ > 10 (rank : 1303)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P55G_HUMAN
NC score	0.125995 (rank : 1138)	θ value	θ > 10 (rank : 1538)
Query Neighborhood Hits	1103	Target Neighborhood Hits	451	Shared Neighborhood Hits	119
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_MOUSE
NC score	0.124846 (rank : 1139)	θ value	θ > 10 (rank : 1543)
Query Neighborhood Hits	1103	Target Neighborhood Hits	519	Shared Neighborhood Hits	126
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DAPP1_MOUSE
NC score	0.123936 (rank : 1140)	θ value	θ > 10 (rank : 1304)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PI3R4_MOUSE
NC score	0.121884 (rank : 1141)	θ value	θ > 10 (rank : 1563)
Query Neighborhood Hits	1103	Target Neighborhood Hits	535	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

HSH2D_HUMAN
NC score	0.121614 (rank : 1142)	θ value	θ > 10 (rank : 1400)
Query Neighborhood Hits	1103	Target Neighborhood Hits	159	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

PLCG1_MOUSE
NC score	0.121472 (rank : 1143)	θ value	θ > 10 (rank : 1580)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	67
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

K2002_MOUSE
NC score	0.121416 (rank : 1144)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	163
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PLCG2_HUMAN
NC score	0.120998 (rank : 1145)	θ value	θ > 10 (rank : 1581)
Query Neighborhood Hits	1103	Target Neighborhood Hits	280	Shared Neighborhood Hits	57
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.120139 (rank : 1146)	θ value	θ > 10 (rank : 1579)
Query Neighborhood Hits	1103	Target Neighborhood Hits	293	Shared Neighborhood Hits	64
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

P85B_HUMAN
NC score	0.119400 (rank : 1147)	θ value	θ > 10 (rank : 1542)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	129
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

VAV2_HUMAN
NC score	0.119323 (rank : 1148)	θ value	θ > 10 (rank : 1779)
Query Neighborhood Hits	1103	Target Neighborhood Hits	453	Shared Neighborhood Hits	99
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SHE_MOUSE
NC score	0.119112 (rank : 1149)	θ value	θ > 10 (rank : 1670)
Query Neighborhood Hits	1103	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

P55G_MOUSE
NC score	0.118667 (rank : 1150)	θ value	θ > 10 (rank : 1539)
Query Neighborhood Hits	1103	Target Neighborhood Hits	401	Shared Neighborhood Hits	107
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

BAT4_HUMAN
NC score	0.118550 (rank : 1151)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

CRK_HUMAN
NC score	0.118301 (rank : 1152)	θ value	θ > 10 (rank : 1290)
Query Neighborhood Hits	1103	Target Neighborhood Hits	308	Shared Neighborhood Hits	63
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

VAV_HUMAN
NC score	0.117861 (rank : 1153)	θ value	θ > 10 (rank : 1783)
Query Neighborhood Hits	1103	Target Neighborhood Hits	452	Shared Neighborhood Hits	99
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SHE_HUMAN
NC score	0.117598 (rank : 1154)	θ value	θ > 10 (rank : 1669)
Query Neighborhood Hits	1103	Target Neighborhood Hits	164	Shared Neighborhood Hits	51
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PI3R4_HUMAN
NC score	0.116774 (rank : 1155)	θ value	θ > 10 (rank : 1562)
Query Neighborhood Hits	1103	Target Neighborhood Hits	534	Shared Neighborhood Hits	231
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

GRB14_MOUSE
NC score	0.116041 (rank : 1156)	θ value	θ > 10 (rank : 1373)
Query Neighborhood Hits	1103	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

CRK_MOUSE
NC score	0.116016 (rank : 1157)	θ value	θ > 10 (rank : 1291)
Query Neighborhood Hits	1103	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC3_HUMAN
NC score	0.115771 (rank : 1158)	θ value	θ > 10 (rank : 1705)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV2_MOUSE
NC score	0.114807 (rank : 1159)	θ value	θ > 10 (rank : 1780)
Query Neighborhood Hits	1103	Target Neighborhood Hits	456	Shared Neighborhood Hits	93
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

STAC3_MOUSE
NC score	0.114588 (rank : 1160)	θ value	θ > 10 (rank : 1706)
Query Neighborhood Hits	1103	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ABTB1_HUMAN
NC score	0.114462 (rank : 1161)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	140
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

SH24A_HUMAN
NC score	0.114089 (rank : 1162)	θ value	θ > 10 (rank : 1650)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	139
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

RSNL2_HUMAN
NC score	0.112094 (rank : 1163)	θ value	θ > 10 (rank : 1628)
Query Neighborhood Hits	1103	Target Neighborhood Hits	136	Shared Neighborhood Hits	110
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

STAC_MOUSE
NC score	0.111589 (rank : 1164)	θ value	θ > 10 (rank : 1708)
Query Neighborhood Hits	1103	Target Neighborhood Hits	268	Shared Neighborhood Hits	80
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV_MOUSE
NC score	0.110866 (rank : 1165)	θ value	θ > 10 (rank : 1784)
Query Neighborhood Hits	1103	Target Neighborhood Hits	430	Shared Neighborhood Hits	96
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRB14_HUMAN
NC score	0.109368 (rank : 1166)	θ value	θ > 10 (rank : 1372)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ANKR9_HUMAN
NC score	0.107499 (rank : 1167)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	1103	Target Neighborhood Hits	99	Shared Neighborhood Hits	89
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

NPHP1_MOUSE
NC score	0.104637 (rank : 1168)	θ value	θ > 10 (rank : 1530)
Query Neighborhood Hits	1103	Target Neighborhood Hits	267	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

APS_HUMAN
NC score	0.102758 (rank : 1169)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	1103	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

STAC_HUMAN
NC score	0.102188 (rank : 1170)	θ value	θ > 10 (rank : 1707)
Query Neighborhood Hits	1103	Target Neighborhood Hits	276	Shared Neighborhood Hits	81
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB7_MOUSE
NC score	0.101951 (rank : 1171)	θ value	θ > 10 (rank : 1377)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

CIP4_HUMAN
NC score	0.101641 (rank : 1172)	θ value	6.88961 (rank : 1028)
Query Neighborhood Hits	1103	Target Neighborhood Hits	374	Shared Neighborhood Hits	86
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

NPHP1_HUMAN
NC score	0.101392 (rank : 1173)	θ value	θ > 10 (rank : 1529)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	72
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

P85A_HUMAN
NC score	0.100670 (rank : 1174)	θ value	θ > 10 (rank : 1540)
Query Neighborhood Hits	1103	Target Neighborhood Hits	479	Shared Neighborhood Hits	95
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.100306 (rank : 1175)	θ value	θ > 10 (rank : 1541)
Query Neighborhood Hits	1103	Target Neighborhood Hits	435	Shared Neighborhood Hits	87
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DMP1_HUMAN
NC score	0.100059 (rank : 1176)	θ value	0.00228821 (rank : 419)
Query Neighborhood Hits	1103	Target Neighborhood Hits	491	Shared Neighborhood Hits	136
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

SHC2_HUMAN
NC score	0.098401 (rank : 1177)	θ value	θ > 10 (rank : 1663)
Query Neighborhood Hits	1103	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC1_HUMAN
NC score	0.098050 (rank : 1178)	θ value	θ > 10 (rank : 1661)
Query Neighborhood Hits	1103	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
NC score	0.097436 (rank : 1179)	θ value	θ > 10 (rank : 1662)
Query Neighborhood Hits	1103	Target Neighborhood Hits	180	Shared Neighborhood Hits	47
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHB_MOUSE
NC score	0.097235 (rank : 1180)	θ value	θ > 10 (rank : 1660)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

LNK_HUMAN
NC score	0.096831 (rank : 1181)	θ value	θ > 10 (rank : 1455)
Query Neighborhood Hits	1103	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ITSN1_MOUSE
NC score	0.096566 (rank : 1182)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1669	Shared Neighborhood Hits	276
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RSNL2_MOUSE
NC score	0.096271 (rank : 1183)	θ value	θ > 10 (rank : 1629)
Query Neighborhood Hits	1103	Target Neighborhood Hits	129	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

TRPV1_MOUSE
NC score	0.095313 (rank : 1184)	θ value	θ > 10 (rank : 1752)
Query Neighborhood Hits	1103	Target Neighborhood Hits	189	Shared Neighborhood Hits	137
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

SPN90_HUMAN
NC score	0.095181 (rank : 1185)	θ value	θ > 10 (rank : 1687)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

GRB7_HUMAN
NC score	0.094910 (rank : 1186)	θ value	θ > 10 (rank : 1376)
Query Neighborhood Hits	1103	Target Neighborhood Hits	156	Shared Neighborhood Hits	42
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

ES8L3_HUMAN
NC score	0.093818 (rank : 1187)	θ value	θ > 10 (rank : 1342)
Query Neighborhood Hits	1103	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PXK_MOUSE
NC score	0.093714 (rank : 1188)	θ value	θ > 10 (rank : 1601)
Query Neighborhood Hits	1103	Target Neighborhood Hits	320	Shared Neighborhood Hits	165
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SHD_MOUSE
NC score	0.093300 (rank : 1189)	θ value	θ > 10 (rank : 1668)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

TRPV3_MOUSE
NC score	0.093165 (rank : 1190)	θ value	θ > 10 (rank : 1756)
Query Neighborhood Hits	1103	Target Neighborhood Hits	188	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

ITSN1_HUMAN
NC score	0.093039 (rank : 1191)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1757	Shared Neighborhood Hits	271
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NEO1_HUMAN
NC score	0.092965 (rank : 1192)	θ value	θ > 10 (rank : 1522)
Query Neighborhood Hits	1103	Target Neighborhood Hits	530	Shared Neighborhood Hits	93
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

CYLC1_HUMAN
NC score	0.092874 (rank : 1193)	θ value	0.0113563 (rank : 500)
Query Neighborhood Hits	1103	Target Neighborhood Hits	408	Shared Neighborhood Hits	93
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

SHB_HUMAN
NC score	0.092465 (rank : 1194)	θ value	θ > 10 (rank : 1659)
Query Neighborhood Hits	1103	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PRPK_MOUSE
NC score	0.092236 (rank : 1195)	θ value	θ > 10 (rank : 1589)
Query Neighborhood Hits	1103	Target Neighborhood Hits	139	Shared Neighborhood Hits	100
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

NEO1_MOUSE
NC score	0.092053 (rank : 1196)	θ value	θ > 10 (rank : 1523)
Query Neighborhood Hits	1103	Target Neighborhood Hits	523	Shared Neighborhood Hits	92
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

LEO1_HUMAN
NC score	0.091927 (rank : 1197)	θ value	0.0252991 (rank : 558)
Query Neighborhood Hits	1103	Target Neighborhood Hits	958	Shared Neighborhood Hits	213
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

TRPV3_HUMAN
NC score	0.091531 (rank : 1198)	θ value	θ > 10 (rank : 1755)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	126
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

SHC2_MOUSE
NC score	0.090937 (rank : 1199)	θ value	θ > 10 (rank : 1664)
Query Neighborhood Hits	1103	Target Neighborhood Hits	144	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHD_HUMAN
NC score	0.090929 (rank : 1200)	θ value	θ > 10 (rank : 1667)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

IWS1_HUMAN
NC score	0.090926 (rank : 1201)	θ value	1.38821 (rank : 825)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1241	Shared Neighborhood Hits	242
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SHC3_MOUSE
NC score	0.090875 (rank : 1202)	θ value	θ > 10 (rank : 1666)
Query Neighborhood Hits	1103	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ARI4A_HUMAN
NC score	0.090824 (rank : 1203)	θ value	0.0148317 (rank : 512)
Query Neighborhood Hits	1103	Target Neighborhood Hits	434	Shared Neighborhood Hits	102
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

SH24A_MOUSE
NC score	0.090132 (rank : 1204)	θ value	θ > 10 (rank : 1651)
Query Neighborhood Hits	1103	Target Neighborhood Hits	326	Shared Neighborhood Hits	111
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SPN90_MOUSE
NC score	0.089293 (rank : 1205)	θ value	θ > 10 (rank : 1688)
Query Neighborhood Hits	1103	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ITSN2_MOUSE
NC score	0.089168 (rank : 1206)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1371	Shared Neighborhood Hits	221
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

IWS1_MOUSE
NC score	0.089085 (rank : 1207)	θ value	0.00509761 (rank : 464)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1258	Shared Neighborhood Hits	232
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LNK_MOUSE
NC score	0.089068 (rank : 1208)	θ value	θ > 10 (rank : 1456)
Query Neighborhood Hits	1103	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

TRPV1_HUMAN
NC score	0.088400 (rank : 1209)	θ value	θ > 10 (rank : 1751)
Query Neighborhood Hits	1103	Target Neighborhood Hits	184	Shared Neighborhood Hits	133
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

ITSN2_HUMAN
NC score	0.088024 (rank : 1210)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1173	Shared Neighborhood Hits	178
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LEO1_MOUSE
NC score	0.087464 (rank : 1211)	θ value	0.0563607 (rank : 609)
Query Neighborhood Hits	1103	Target Neighborhood Hits	946	Shared Neighborhood Hits	208
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PRPK_HUMAN
NC score	0.086982 (rank : 1212)	θ value	θ > 10 (rank : 1588)
Query Neighborhood Hits	1103	Target Neighborhood Hits	131	Shared Neighborhood Hits	101
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

CMTA1_HUMAN
NC score	0.085590 (rank : 1213)	θ value	θ > 10 (rank : 1266)
Query Neighborhood Hits	1103	Target Neighborhood Hits	217	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

RSF1_HUMAN
NC score	0.085314 (rank : 1214)	θ value	0.0113563 (rank : 506)
Query Neighborhood Hits	1103	Target Neighborhood Hits	539	Shared Neighborhood Hits	120
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

DCC_MOUSE
NC score	0.084050 (rank : 1215)	θ value	θ > 10 (rank : 1307)
Query Neighborhood Hits	1103	Target Neighborhood Hits	896	Shared Neighborhood Hits	134
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

STAM2_MOUSE
NC score	0.083869 (rank : 1216)	θ value	θ > 10 (rank : 1712)
Query Neighborhood Hits	1103	Target Neighborhood Hits	285	Shared Neighborhood Hits	64
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SHC3_HUMAN
NC score	0.083759 (rank : 1217)	θ value	θ > 10 (rank : 1665)
Query Neighborhood Hits	1103	Target Neighborhood Hits	155	Shared Neighborhood Hits	40
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SDK1_HUMAN
NC score	0.083538 (rank : 1218)	θ value	θ > 10 (rank : 1634)
Query Neighborhood Hits	1103	Target Neighborhood Hits	511	Shared Neighborhood Hits	88
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

DCC_HUMAN
NC score	0.083405 (rank : 1219)	θ value	θ > 10 (rank : 1306)
Query Neighborhood Hits	1103	Target Neighborhood Hits	583	Shared Neighborhood Hits	95
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

GRB10_MOUSE
NC score	0.082115 (rank : 1220)	θ value	θ > 10 (rank : 1371)
Query Neighborhood Hits	1103	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

SDK1_MOUSE
NC score	0.081677 (rank : 1221)	θ value	θ > 10 (rank : 1635)
Query Neighborhood Hits	1103	Target Neighborhood Hits	495	Shared Neighborhood Hits	87
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

GRB10_HUMAN
NC score	0.081626 (rank : 1222)	θ value	θ > 10 (rank : 1370)
Query Neighborhood Hits	1103	Target Neighborhood Hits	147	Shared Neighborhood Hits	48
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

MAP1B_MOUSE
NC score	0.081438 (rank : 1223)	θ value	0.0431538 (rank : 597)
Query Neighborhood Hits	1103	Target Neighborhood Hits	977	Shared Neighborhood Hits	186
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

SDK2_HUMAN
NC score	0.081393 (rank : 1224)	θ value	θ > 10 (rank : 1636)
Query Neighborhood Hits	1103	Target Neighborhood Hits	495	Shared Neighborhood Hits	92
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

MYOM1_HUMAN
NC score	0.081295 (rank : 1225)	θ value	θ > 10 (rank : 1499)
Query Neighborhood Hits	1103	Target Neighborhood Hits	405	Shared Neighborhood Hits	96
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

STAM1_MOUSE
NC score	0.081119 (rank : 1226)	θ value	θ > 10 (rank : 1710)
Query Neighborhood Hits	1103	Target Neighborhood Hits	273	Shared Neighborhood Hits	56
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

MAP1A_HUMAN
NC score	0.080866 (rank : 1227)	θ value	3.0926 (rank : 923)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1626	Shared Neighborhood Hits	270
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

DSCL1_HUMAN
NC score	0.080545 (rank : 1228)	θ value	θ > 10 (rank : 1319)
Query Neighborhood Hits	1103	Target Neighborhood Hits	589	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DGKD_HUMAN
NC score	0.080508 (rank : 1229)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	1103	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

TRPV2_HUMAN
NC score	0.080389 (rank : 1230)	θ value	θ > 10 (rank : 1753)
Query Neighborhood Hits	1103	Target Neighborhood Hits	130	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

APS_MOUSE
NC score	0.079757 (rank : 1231)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	1103	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

STAM1_HUMAN
NC score	0.079731 (rank : 1232)	θ value	θ > 10 (rank : 1709)
Query Neighborhood Hits	1103	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ES8L3_MOUSE
NC score	0.079647 (rank : 1233)	θ value	θ > 10 (rank : 1343)
Query Neighborhood Hits	1103	Target Neighborhood Hits	168	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

STAM2_HUMAN
NC score	0.079246 (rank : 1234)	θ value	θ > 10 (rank : 1711)
Query Neighborhood Hits	1103	Target Neighborhood Hits	288	Shared Neighborhood Hits	61
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SDK2_MOUSE
NC score	0.078792 (rank : 1235)	θ value	θ > 10 (rank : 1637)
Query Neighborhood Hits	1103	Target Neighborhood Hits	480	Shared Neighborhood Hits	87
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

PHLB2_MOUSE
NC score	0.078224 (rank : 1236)	θ value	0.0193708 (rank : 548)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1016	Shared Neighborhood Hits	188
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
NC score	0.078006 (rank : 1237)	θ value	0.00102713 (rank : 369)
Query Neighborhood Hits	1103	Target Neighborhood Hits	964	Shared Neighborhood Hits	172
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

NIPBL_HUMAN
NC score	0.077602 (rank : 1238)	θ value	5.27518 (rank : 1004)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1311	Shared Neighborhood Hits	266
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PPIP1_HUMAN
NC score	0.077222 (rank : 1239)	θ value	θ > 10 (rank : 1584)
Query Neighborhood Hits	1103	Target Neighborhood Hits	389	Shared Neighborhood Hits	96
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

DSCAM_HUMAN
NC score	0.076902 (rank : 1240)	θ value	θ > 10 (rank : 1318)
Query Neighborhood Hits	1103	Target Neighborhood Hits	524	Shared Neighborhood Hits	82
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

SOCS7_MOUSE
NC score	0.076825 (rank : 1241)	θ value	θ > 10 (rank : 1684)
Query Neighborhood Hits	1103	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

L1CAM_HUMAN
NC score	0.076811 (rank : 1242)	θ value	θ > 10 (rank : 1444)
Query Neighborhood Hits	1103	Target Neighborhood Hits	457	Shared Neighborhood Hits	85
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

GOGB1_HUMAN
NC score	0.076782 (rank : 1243)	θ value	0.0330416 (rank : 576)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2297	Shared Neighborhood Hits	291
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SHAN2_MOUSE
NC score	0.076644 (rank : 1244)	θ value	θ > 10 (rank : 1658)
Query Neighborhood Hits	1103	Target Neighborhood Hits	446	Shared Neighborhood Hits	87
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

CCD96_MOUSE
NC score	0.076285 (rank : 1245)	θ value	0.365318 (rank : 713)
Query Neighborhood Hits	1103	Target Neighborhood Hits	704	Shared Neighborhood Hits	164
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

MAP1B_HUMAN
NC score	0.076232 (rank : 1246)	θ value	0.0961366 (rank : 640)
Query Neighborhood Hits	1103	Target Neighborhood Hits	903	Shared Neighborhood Hits	161
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

NEST_HUMAN
NC score	0.075948 (rank : 1247)	θ value	0.00509761 (rank : 465)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1305	Shared Neighborhood Hits	226
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

MYOM1_MOUSE
NC score	0.075841 (rank : 1248)	θ value	θ > 10 (rank : 1500)
Query Neighborhood Hits	1103	Target Neighborhood Hits	415	Shared Neighborhood Hits	85
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

NRCAM_HUMAN
NC score	0.075635 (rank : 1249)	θ value	θ > 10 (rank : 1533)
Query Neighborhood Hits	1103	Target Neighborhood Hits	439	Shared Neighborhood Hits	86
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

PTN11_MOUSE
NC score	0.075532 (rank : 1250)	θ value	θ > 10 (rank : 1591)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.075380 (rank : 1251)	θ value	θ > 10 (rank : 1590)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

ACINU_MOUSE
NC score	0.074984 (rank : 1252)	θ value	0.0736092 (rank : 617)
Query Neighborhood Hits	1103	Target Neighborhood Hits	712	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

PPIP1_MOUSE
NC score	0.074786 (rank : 1253)	θ value	θ > 10 (rank : 1585)
Query Neighborhood Hits	1103	Target Neighborhood Hits	377	Shared Neighborhood Hits	94
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

AKA12_HUMAN
NC score	0.074224 (rank : 1254)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	207
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

NASP_HUMAN
NC score	0.074193 (rank : 1255)	θ value	8.99809 (rank : 1082)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	178
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

CU081_HUMAN
NC score	0.073986 (rank : 1256)	θ value	θ > 10 (rank : 1301)
Query Neighborhood Hits	1103	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

NFASC_HUMAN
NC score	0.073803 (rank : 1257)	θ value	θ > 10 (rank : 1524)
Query Neighborhood Hits	1103	Target Neighborhood Hits	497	Shared Neighborhood Hits	94
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

ACINU_HUMAN
NC score	0.073800 (rank : 1258)	θ value	0.47712 (rank : 735)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	190
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

DSPP_MOUSE
NC score	0.073718 (rank : 1259)	θ value	0.00020696 (rank : 309)
Query Neighborhood Hits	1103	Target Neighborhood Hits	491	Shared Neighborhood Hits	95
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

NCAM2_MOUSE
NC score	0.073548 (rank : 1260)	θ value	θ > 10 (rank : 1513)
Query Neighborhood Hits	1103	Target Neighborhood Hits	472	Shared Neighborhood Hits	78
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

MYOM2_HUMAN
NC score	0.073255 (rank : 1261)	θ value	θ > 10 (rank : 1501)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

FGRL1_MOUSE
NC score	0.073236 (rank : 1262)	θ value	θ > 10 (rank : 1347)
Query Neighborhood Hits	1103	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

CI039_HUMAN
NC score	0.073101 (rank : 1263)	θ value	θ > 10 (rank : 1250)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1171	Shared Neighborhood Hits	200
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

GOGA4_MOUSE
NC score	0.072984 (rank : 1264)	θ value	0.00298849 (rank : 436)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1939	Shared Neighborhood Hits	257
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

NRCAM_MOUSE
NC score	0.072858 (rank : 1265)	θ value	θ > 10 (rank : 1534)
Query Neighborhood Hits	1103	Target Neighborhood Hits	432	Shared Neighborhood Hits	86
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NOP14_HUMAN
NC score	0.072851 (rank : 1266)	θ value	θ > 10 (rank : 1528)
Query Neighborhood Hits	1103	Target Neighborhood Hits	573	Shared Neighborhood Hits	150
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

PACN2_MOUSE
NC score	0.072829 (rank : 1267)	θ value	θ > 10 (rank : 1547)
Query Neighborhood Hits	1103	Target Neighborhood Hits	382	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ZC313_HUMAN
NC score	0.072593 (rank : 1268)	θ value	3.0926 (rank : 946)
Query Neighborhood Hits	1103	Target Neighborhood Hits	772	Shared Neighborhood Hits	184
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

LCP2_HUMAN
NC score	0.072561 (rank : 1269)	θ value	θ > 10 (rank : 1451)
Query Neighborhood Hits	1103	Target Neighborhood Hits	531	Shared Neighborhood Hits	95
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ROBO1_HUMAN
NC score	0.072137 (rank : 1270)	θ value	θ > 10 (rank : 1617)
Query Neighborhood Hits	1103	Target Neighborhood Hits	529	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

PACN2_HUMAN
NC score	0.072084 (rank : 1271)	θ value	θ > 10 (rank : 1546)
Query Neighborhood Hits	1103	Target Neighborhood Hits	339	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RENT2_HUMAN
NC score	0.072077 (rank : 1272)	θ value	0.21417 (rank : 694)
Query Neighborhood Hits	1103	Target Neighborhood Hits	618	Shared Neighborhood Hits	120
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

TXND2_MOUSE
NC score	0.072017 (rank : 1273)	θ value	θ > 10 (rank : 1773)
Query Neighborhood Hits	1103	Target Neighborhood Hits	828	Shared Neighborhood Hits	206
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

ROBO2_MOUSE
NC score	0.071918 (rank : 1274)	θ value	θ > 10 (rank : 1620)
Query Neighborhood Hits	1103	Target Neighborhood Hits	504	Shared Neighborhood Hits	82
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

L1CAM_MOUSE
NC score	0.071890 (rank : 1275)	θ value	θ > 10 (rank : 1445)
Query Neighborhood Hits	1103	Target Neighborhood Hits	457	Shared Neighborhood Hits	85
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

ROBO2_HUMAN
NC score	0.071867 (rank : 1276)	θ value	θ > 10 (rank : 1619)
Query Neighborhood Hits	1103	Target Neighborhood Hits	479	Shared Neighborhood Hits	75
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

FNDC3_MOUSE
NC score	0.071834 (rank : 1277)	θ value	θ > 10 (rank : 1351)
Query Neighborhood Hits	1103	Target Neighborhood Hits	207	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

PACN3_HUMAN
NC score	0.071752 (rank : 1278)	θ value	θ > 10 (rank : 1548)
Query Neighborhood Hits	1103	Target Neighborhood Hits	385	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ROBO1_MOUSE
NC score	0.071620 (rank : 1279)	θ value	θ > 10 (rank : 1618)
Query Neighborhood Hits	1103	Target Neighborhood Hits	559	Shared Neighborhood Hits	88
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

PTPRD_HUMAN
NC score	0.071564 (rank : 1280)	θ value	θ > 10 (rank : 1594)
Query Neighborhood Hits	1103	Target Neighborhood Hits	485	Shared Neighborhood Hits	85
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

AHI1_HUMAN
NC score	0.071453 (rank : 1281)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	1103	Target Neighborhood Hits	537	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

GOGA4_HUMAN
NC score	0.071358 (rank : 1282)	θ value	0.365318 (rank : 717)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2034	Shared Neighborhood Hits	244
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PTPRD_MOUSE
NC score	0.071231 (rank : 1283)	θ value	θ > 10 (rank : 1595)
Query Neighborhood Hits	1103	Target Neighborhood Hits	491	Shared Neighborhood Hits	83
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

FNDC3_HUMAN
NC score	0.071000 (rank : 1284)	θ value	θ > 10 (rank : 1350)
Query Neighborhood Hits	1103	Target Neighborhood Hits	196	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FGRL1_HUMAN
NC score	0.070478 (rank : 1285)	θ value	θ > 10 (rank : 1346)
Query Neighborhood Hits	1103	Target Neighborhood Hits	335	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

NCAM2_HUMAN
NC score	0.070460 (rank : 1286)	θ value	θ > 10 (rank : 1512)
Query Neighborhood Hits	1103	Target Neighborhood Hits	441	Shared Neighborhood Hits	76
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

ANM2_HUMAN
NC score	0.070364 (rank : 1287)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	1103	Target Neighborhood Hits	175	Shared Neighborhood Hits	42
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PTPRS_HUMAN
NC score	0.070302 (rank : 1288)	θ value	θ > 10 (rank : 1597)
Query Neighborhood Hits	1103	Target Neighborhood Hits	472	Shared Neighborhood Hits	85
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRF_HUMAN
NC score	0.070271 (rank : 1289)	θ value	θ > 10 (rank : 1596)
Query Neighborhood Hits	1103	Target Neighborhood Hits	489	Shared Neighborhood Hits	85
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

SH2D3_MOUSE
NC score	0.069988 (rank : 1290)	θ value	θ > 10 (rank : 1653)
Query Neighborhood Hits	1103	Target Neighborhood Hits	174	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

DNMBP_HUMAN
NC score	0.069812 (rank : 1291)	θ value	θ > 10 (rank : 1317)
Query Neighborhood Hits	1103	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CCD46_MOUSE
NC score	0.069767 (rank : 1292)	θ value	1.81305 (rank : 850)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1405	Shared Neighborhood Hits	215
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

MDN1_HUMAN
NC score	0.069634 (rank : 1293)	θ value	1.38821 (rank : 833)
Query Neighborhood Hits	1103	Target Neighborhood Hits	662	Shared Neighborhood Hits	165
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

IF2P_HUMAN
NC score	0.069558 (rank : 1294)	θ value	6.88961 (rank : 1033)
Query Neighborhood Hits	1103	Target Neighborhood Hits	889	Shared Neighborhood Hits	151
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

PACN1_HUMAN
NC score	0.069425 (rank : 1295)	θ value	θ > 10 (rank : 1544)
Query Neighborhood Hits	1103	Target Neighborhood Hits	320	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PIBF1_HUMAN
NC score	0.069406 (rank : 1296)	θ value	3.0926 (rank : 933)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1041	Shared Neighborhood Hits	177
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

DSPP_HUMAN
NC score	0.069345 (rank : 1297)	θ value	0.0113563 (rank : 501)
Query Neighborhood Hits	1103	Target Neighborhood Hits	645	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

PCNT_HUMAN
NC score	0.069070 (rank : 1298)	θ value	0.0252991 (rank : 563)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1551	Shared Neighborhood Hits	218
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

INCE_HUMAN
NC score	0.069041 (rank : 1299)	θ value	8.99809 (rank : 1075)
Query Neighborhood Hits	1103	Target Neighborhood Hits	978	Shared Neighborhood Hits	160
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

NEBL_HUMAN
NC score	0.068770 (rank : 1300)	θ value	θ > 10 (rank : 1519)
Query Neighborhood Hits	1103	Target Neighborhood Hits	457	Shared Neighborhood Hits	117
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

TPR_HUMAN
NC score	0.068755 (rank : 1301)	θ value	6.88961 (rank : 1056)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1921	Shared Neighborhood Hits	261
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

ROBO3_HUMAN
NC score	0.068425 (rank : 1302)	θ value	θ > 10 (rank : 1621)
Query Neighborhood Hits	1103	Target Neighborhood Hits	570	Shared Neighborhood Hits	92
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

SPTA2_HUMAN
NC score	0.068366 (rank : 1303)	θ value	θ > 10 (rank : 1691)
Query Neighborhood Hits	1103	Target Neighborhood Hits	888	Shared Neighborhood Hits	143
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

RBBP6_MOUSE
NC score	0.068197 (rank : 1304)	θ value	θ > 10 (rank : 1609)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1014	Shared Neighborhood Hits	191
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

YTDC1_HUMAN
NC score	0.068178 (rank : 1305)	θ value	0.0330416 (rank : 586)
Query Neighborhood Hits	1103	Target Neighborhood Hits	458	Shared Neighborhood Hits	115
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

PACN3_MOUSE
NC score	0.068152 (rank : 1306)	θ value	θ > 10 (rank : 1549)
Query Neighborhood Hits	1103	Target Neighborhood Hits	380	Shared Neighborhood Hits	99
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

TRHY_HUMAN
NC score	0.068051 (rank : 1307)	θ value	0.0330416 (rank : 585)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1385	Shared Neighborhood Hits	184
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

VINEX_MOUSE
NC score	0.067974 (rank : 1308)	θ value	θ > 10 (rank : 1786)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CD2AP_HUMAN
NC score	0.067882 (rank : 1309)	θ value	θ > 10 (rank : 1206)
Query Neighborhood Hits	1103	Target Neighborhood Hits	315	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CNTN5_HUMAN
NC score	0.067872 (rank : 1310)	θ value	θ > 10 (rank : 1279)
Query Neighborhood Hits	1103	Target Neighborhood Hits	446	Shared Neighborhood Hits	79
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

RIMB1_MOUSE
NC score	0.067688 (rank : 1311)	θ value	θ > 10 (rank : 1613)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1376	Shared Neighborhood Hits	233
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CEP35_HUMAN
NC score	0.067532 (rank : 1312)	θ value	θ > 10 (rank : 1239)
Query Neighborhood Hits	1103	Target Neighborhood Hits	811	Shared Neighborhood Hits	192
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CENPF_HUMAN
NC score	0.067449 (rank : 1313)	θ value	0.00665767 (rank : 471)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1932	Shared Neighborhood Hits	241
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

REN3B_HUMAN
NC score	0.067240 (rank : 1314)	θ value	θ > 10 (rank : 1611)
Query Neighborhood Hits	1103	Target Neighborhood Hits	412	Shared Neighborhood Hits	101
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

AHI1_MOUSE
NC score	0.067069 (rank : 1315)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	1103	Target Neighborhood Hits	496	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

PACN1_MOUSE
NC score	0.067056 (rank : 1316)	θ value	θ > 10 (rank : 1545)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	58
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

HSH2D_MOUSE
NC score	0.066972 (rank : 1317)	θ value	θ > 10 (rank : 1401)
Query Neighborhood Hits	1103	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

DNMBP_MOUSE
NC score	0.066960 (rank : 1318)	θ value	2.36792 (rank : 885)
Query Neighborhood Hits	1103	Target Neighborhood Hits	435	Shared Neighborhood Hits	87
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ES8L2_MOUSE
NC score	0.066940 (rank : 1319)	θ value	θ > 10 (rank : 1341)
Query Neighborhood Hits	1103	Target Neighborhood Hits	169	Shared Neighborhood Hits	42
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

CK5P2_HUMAN
NC score	0.066849 (rank : 1320)	θ value	θ > 10 (rank : 1255)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1433	Shared Neighborhood Hits	236
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CT2NL_HUMAN
NC score	0.066754 (rank : 1321)	θ value	θ > 10 (rank : 1299)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1059	Shared Neighborhood Hits	198
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CMTA2_HUMAN
NC score	0.066713 (rank : 1322)	θ value	θ > 10 (rank : 1267)
Query Neighborhood Hits	1103	Target Neighborhood Hits	199	Shared Neighborhood Hits	90
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

DGKH_HUMAN
NC score	0.066433 (rank : 1323)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	1103	Target Neighborhood Hits	255	Shared Neighborhood Hits	77
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

NSBP1_MOUSE
NC score	0.066304 (rank : 1324)	θ value	0.47712 (rank : 749)
Query Neighborhood Hits	1103	Target Neighborhood Hits	681	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

ROBO3_MOUSE
NC score	0.066296 (rank : 1325)	θ value	θ > 10 (rank : 1622)
Query Neighborhood Hits	1103	Target Neighborhood Hits	524	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

CCD46_HUMAN
NC score	0.066212 (rank : 1326)	θ value	θ > 10 (rank : 1198)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1430	Shared Neighborhood Hits	213
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

REST_HUMAN
NC score	0.066099 (rank : 1327)	θ value	4.03905 (rank : 970)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1605	Shared Neighborhood Hits	228
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

NFASC_MOUSE
NC score	0.066012 (rank : 1328)	θ value	θ > 10 (rank : 1525)
Query Neighborhood Hits	1103	Target Neighborhood Hits	475	Shared Neighborhood Hits	92
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

SRBS1_HUMAN
NC score	0.065997 (rank : 1329)	θ value	8.99809 (rank : 1091)
Query Neighborhood Hits	1103	Target Neighborhood Hits	396	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GCC2_MOUSE
NC score	0.065828 (rank : 1330)	θ value	1.06291 (rank : 788)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1619	Shared Neighborhood Hits	221
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

SH2D3_HUMAN
NC score	0.065794 (rank : 1331)	θ value	θ > 10 (rank : 1652)
Query Neighborhood Hits	1103	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

CCD41_MOUSE
NC score	0.065726 (rank : 1332)	θ value	θ > 10 (rank : 1197)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1399	Shared Neighborhood Hits	217
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CNTN2_HUMAN
NC score	0.065705 (rank : 1333)	θ value	θ > 10 (rank : 1273)
Query Neighborhood Hits	1103	Target Neighborhood Hits	440	Shared Neighborhood Hits	81
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

VINEX_HUMAN
NC score	0.065606 (rank : 1334)	θ value	θ > 10 (rank : 1785)
Query Neighborhood Hits	1103	Target Neighborhood Hits	270	Shared Neighborhood Hits	51
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ES8L2_HUMAN
NC score	0.065536 (rank : 1335)	θ value	θ > 10 (rank : 1340)
Query Neighborhood Hits	1103	Target Neighborhood Hits	193	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RIMB1_HUMAN
NC score	0.065512 (rank : 1336)	θ value	θ > 10 (rank : 1612)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1479	Shared Neighborhood Hits	219
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PCLO_HUMAN
NC score	0.065483 (rank : 1337)	θ value	0.00390308 (rank : 456)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2046	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PININ_MOUSE
NC score	0.065470 (rank : 1338)	θ value	θ > 10 (rank : 1570)
Query Neighborhood Hits	1103	Target Neighborhood Hits	777	Shared Neighborhood Hits	170
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

CNTN2_MOUSE
NC score	0.065435 (rank : 1339)	θ value	θ > 10 (rank : 1274)
Query Neighborhood Hits	1103	Target Neighborhood Hits	450	Shared Neighborhood Hits	79
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

NPBL_MOUSE
NC score	0.065332 (rank : 1340)	θ value	1.81305 (rank : 871)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1041	Shared Neighborhood Hits	224
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

ANM2_MOUSE
NC score	0.065315 (rank : 1341)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	1103	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANKF1_HUMAN
NC score	0.065203 (rank : 1342)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	1103	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ARHG6_HUMAN
NC score	0.065099 (rank : 1343)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	1103	Target Neighborhood Hits	376	Shared Neighborhood Hits	77
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

RB6I2_HUMAN
NC score	0.064863 (rank : 1344)	θ value	5.27518 (rank : 1010)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1584	Shared Neighborhood Hits	235
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

ARHG7_MOUSE
NC score	0.064792 (rank : 1345)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	1103	Target Neighborhood Hits	396	Shared Neighborhood Hits	78
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DMP1_MOUSE
NC score	0.064689 (rank : 1346)	θ value	θ > 10 (rank : 1316)
Query Neighborhood Hits	1103	Target Neighborhood Hits	498	Shared Neighborhood Hits	118
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

MY18A_MOUSE
NC score	0.064451 (rank : 1347)	θ value	θ > 10 (rank : 1497)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1989	Shared Neighborhood Hits	294
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CALD1_HUMAN
NC score	0.064299 (rank : 1348)	θ value	4.03905 (rank : 954)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	155
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

SAS6_HUMAN
NC score	0.064253 (rank : 1349)	θ value	0.62314 (rank : 767)
Query Neighborhood Hits	1103	Target Neighborhood Hits	791	Shared Neighborhood Hits	129
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

SRRM1_MOUSE
NC score	0.064083 (rank : 1350)	θ value	5.27518 (rank : 1013)
Query Neighborhood Hits	1103	Target Neighborhood Hits	966	Shared Neighborhood Hits	153
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SPTA1_MOUSE
NC score	0.063923 (rank : 1351)	θ value	θ > 10 (rank : 1690)
Query Neighborhood Hits	1103	Target Neighborhood Hits	675	Shared Neighborhood Hits	131
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CCD41_HUMAN
NC score	0.063799 (rank : 1352)	θ value	θ > 10 (rank : 1196)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1139	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

PININ_HUMAN
NC score	0.063676 (rank : 1353)	θ value	6.88961 (rank : 1046)
Query Neighborhood Hits	1103	Target Neighborhood Hits	753	Shared Neighborhood Hits	161
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

REST_MOUSE
NC score	0.063660 (rank : 1354)	θ value	0.0148317 (rank : 529)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1506	Shared Neighborhood Hits	208
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

NCA11_HUMAN
NC score	0.063550 (rank : 1355)	θ value	θ > 10 (rank : 1508)
Query Neighborhood Hits	1103	Target Neighborhood Hits	443	Shared Neighborhood Hits	67
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NUCKS_MOUSE
NC score	0.063484 (rank : 1356)	θ value	3.0926 (rank : 931)
Query Neighborhood Hits	1103	Target Neighborhood Hits	114	Shared Neighborhood Hits	40
SwissProt Accessions	Q80XU3, Q8BVD8	Gene names	Nucks1, Nucks
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (JC7).

PGFRL_MOUSE
NC score	0.063372 (rank : 1357)	θ value	θ > 10 (rank : 1560)
Query Neighborhood Hits	1103	Target Neighborhood Hits	106	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

SH22A_MOUSE
NC score	0.063329 (rank : 1358)	θ value	θ > 10 (rank : 1648)
Query Neighborhood Hits	1103	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

GOGA5_MOUSE
NC score	0.063318 (rank : 1359)	θ value	θ > 10 (rank : 1364)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1434	Shared Neighborhood Hits	224
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

CT2NL_MOUSE
NC score	0.063309 (rank : 1360)	θ value	θ > 10 (rank : 1300)
Query Neighborhood Hits	1103	Target Neighborhood Hits	902	Shared Neighborhood Hits	184
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

RBM25_HUMAN
NC score	0.063299 (rank : 1361)	θ value	2.36792 (rank : 898)
Query Neighborhood Hits	1103	Target Neighborhood Hits	682	Shared Neighborhood Hits	128
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

CD2AP_MOUSE
NC score	0.063180 (rank : 1362)	θ value	θ > 10 (rank : 1207)
Query Neighborhood Hits	1103	Target Neighborhood Hits	336	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NCF1_HUMAN
NC score	0.063054 (rank : 1363)	θ value	θ > 10 (rank : 1514)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CCD11_HUMAN
NC score	0.063018 (rank : 1364)	θ value	θ > 10 (rank : 1190)
Query Neighborhood Hits	1103	Target Neighborhood Hits	822	Shared Neighborhood Hits	162
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

NCF1_MOUSE
NC score	0.062993 (rank : 1365)	θ value	θ > 10 (rank : 1515)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

MYPC3_MOUSE
NC score	0.062873 (rank : 1366)	θ value	θ > 10 (rank : 1505)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	62
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

LCP2_MOUSE
NC score	0.062659 (rank : 1367)	θ value	θ > 10 (rank : 1452)
Query Neighborhood Hits	1103	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TRIPB_HUMAN
NC score	0.062566 (rank : 1368)	θ value	θ > 10 (rank : 1750)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1587	Shared Neighborhood Hits	218
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

AKAP9_HUMAN
NC score	0.062494 (rank : 1369)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1710	Shared Neighborhood Hits	215
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

TGON2_HUMAN
NC score	0.062396 (rank : 1370)	θ value	θ > 10 (rank : 1736)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1037	Shared Neighborhood Hits	197
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CMTA2_MOUSE
NC score	0.062395 (rank : 1371)	θ value	θ > 10 (rank : 1268)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	85
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CP250_HUMAN
NC score	0.062343 (rank : 1372)	θ value	θ > 10 (rank : 1286)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1805	Shared Neighborhood Hits	241
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CNTN3_HUMAN
NC score	0.062297 (rank : 1373)	θ value	θ > 10 (rank : 1275)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	75
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

K0555_HUMAN
NC score	0.062286 (rank : 1374)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	1103	Target Neighborhood Hits	880	Shared Neighborhood Hits	153
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

CN145_HUMAN
NC score	0.062245 (rank : 1375)	θ value	θ > 10 (rank : 1269)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1196	Shared Neighborhood Hits	185
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

NCA11_MOUSE
NC score	0.062196 (rank : 1376)	θ value	θ > 10 (rank : 1509)
Query Neighborhood Hits	1103	Target Neighborhood Hits	661	Shared Neighborhood Hits	100
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

BPAEA_MOUSE
NC score	0.062186 (rank : 1377)	θ value	1.38821 (rank : 813)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1480	Shared Neighborhood Hits	214
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

DYNA_HUMAN
NC score	0.062180 (rank : 1378)	θ value	0.0563607 (rank : 604)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1194	Shared Neighborhood Hits	182
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

RBBP6_HUMAN
NC score	0.062099 (rank : 1379)	θ value	θ > 10 (rank : 1608)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1135	Shared Neighborhood Hits	207
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

MY18A_HUMAN
NC score	0.062074 (rank : 1380)	θ value	θ > 10 (rank : 1496)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1929	Shared Neighborhood Hits	281
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

INVO_HUMAN
NC score	0.062022 (rank : 1381)	θ value	1.38821 (rank : 823)
Query Neighborhood Hits	1103	Target Neighborhood Hits	636	Shared Neighborhood Hits	119
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

NCA12_HUMAN
NC score	0.061745 (rank : 1382)	θ value	θ > 10 (rank : 1510)
Query Neighborhood Hits	1103	Target Neighborhood Hits	437	Shared Neighborhood Hits	66
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

SAS6_MOUSE
NC score	0.061742 (rank : 1383)	θ value	0.813845 (rank : 776)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	147
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

RBCC1_HUMAN
NC score	0.061689 (rank : 1384)	θ value	2.36792 (rank : 897)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1023	Shared Neighborhood Hits	168
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

ES8L1_HUMAN
NC score	0.061642 (rank : 1385)	θ value	θ > 10 (rank : 1339)
Query Neighborhood Hits	1103	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

INCE_MOUSE
NC score	0.061626 (rank : 1386)	θ value	θ > 10 (rank : 1405)
Query Neighborhood Hits	1103	Target Neighborhood Hits	903	Shared Neighborhood Hits	147
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

DESP_HUMAN
NC score	0.061618 (rank : 1387)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1470	Shared Neighborhood Hits	215
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

RIF1_HUMAN
NC score	0.061611 (rank : 1388)	θ value	0.0252991 (rank : 566)
Query Neighborhood Hits	1103	Target Neighborhood Hits	320	Shared Neighborhood Hits	91
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

PGFRL_HUMAN
NC score	0.061409 (rank : 1389)	θ value	θ > 10 (rank : 1559)
Query Neighborhood Hits	1103	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

SRRM1_HUMAN
NC score	0.061213 (rank : 1390)	θ value	8.99809 (rank : 1093)
Query Neighborhood Hits	1103	Target Neighborhood Hits	690	Shared Neighborhood Hits	116
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

ARHG7_HUMAN
NC score	0.061127 (rank : 1391)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	1103	Target Neighborhood Hits	347	Shared Neighborhood Hits	54
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SYCP1_HUMAN
NC score	0.061107 (rank : 1392)	θ value	θ > 10 (rank : 1723)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1313	Shared Neighborhood Hits	215
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CP135_MOUSE
NC score	0.061073 (rank : 1393)	θ value	θ > 10 (rank : 1285)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1278	Shared Neighborhood Hits	183
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CF060_HUMAN
NC score	0.061062 (rank : 1394)	θ value	θ > 10 (rank : 1241)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1270	Shared Neighborhood Hits	200
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

DYNA_MOUSE
NC score	0.060861 (rank : 1395)	θ value	0.0563607 (rank : 605)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1084	Shared Neighborhood Hits	160
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

CENPE_HUMAN
NC score	0.060846 (rank : 1396)	θ value	0.0961366 (rank : 633)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2060	Shared Neighborhood Hits	255
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

PUNC_HUMAN
NC score	0.060805 (rank : 1397)	θ value	θ > 10 (rank : 1598)
Query Neighborhood Hits	1103	Target Neighborhood Hits	449	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

BOC_HUMAN
NC score	0.060732 (rank : 1398)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CHIN_MOUSE
NC score	0.060707 (rank : 1399)	θ value	θ > 10 (rank : 1244)
Query Neighborhood Hits	1103	Target Neighborhood Hits	229	Shared Neighborhood Hits	59
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ARHG6_MOUSE
NC score	0.060674 (rank : 1400)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	1103	Target Neighborhood Hits	394	Shared Neighborhood Hits	92
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

RBCC1_MOUSE
NC score	0.060591 (rank : 1401)	θ value	3.0926 (rank : 934)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1048	Shared Neighborhood Hits	170
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RB6I2_MOUSE
NC score	0.060533 (rank : 1402)	θ value	θ > 10 (rank : 1607)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1433	Shared Neighborhood Hits	206
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

CE290_HUMAN
NC score	0.060421 (rank : 1403)	θ value	5.27518 (rank : 985)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1553	Shared Neighborhood Hits	203
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CHIO_HUMAN
NC score	0.060000 (rank : 1404)	θ value	θ > 10 (rank : 1245)
Query Neighborhood Hits	1103	Target Neighborhood Hits	220	Shared Neighborhood Hits	57
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TRDN_HUMAN
NC score	0.059987 (rank : 1405)	θ value	θ > 10 (rank : 1743)
Query Neighborhood Hits	1103	Target Neighborhood Hits	542	Shared Neighborhood Hits	112
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

GRAP1_MOUSE
NC score	0.059820 (rank : 1406)	θ value	θ > 10 (rank : 1365)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1234	Shared Neighborhood Hits	186
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

SFR12_HUMAN
NC score	0.059808 (rank : 1407)	θ value	θ > 10 (rank : 1638)
Query Neighborhood Hits	1103	Target Neighborhood Hits	553	Shared Neighborhood Hits	109
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

TARSH_HUMAN
NC score	0.059703 (rank : 1408)	θ value	θ > 10 (rank : 1728)
Query Neighborhood Hits	1103	Target Neighborhood Hits	768	Shared Neighborhood Hits	113
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

CING_MOUSE
NC score	0.059645 (rank : 1409)	θ value	θ > 10 (rank : 1253)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1432	Shared Neighborhood Hits	215
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

NUCKS_HUMAN
NC score	0.059631 (rank : 1410)	θ value	4.03905 (rank : 964)
Query Neighborhood Hits	1103	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H1E3, Q9H1D6, Q9H723	Gene names	NUCKS1, NUCKS
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1).

CHIN_HUMAN
NC score	0.059551 (rank : 1411)	θ value	θ > 10 (rank : 1243)
Query Neighborhood Hits	1103	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

MYST3_MOUSE
NC score	0.059535 (rank : 1412)	θ value	0.00020696 (rank : 314)
Query Neighborhood Hits	1103	Target Neighborhood Hits	688	Shared Neighborhood Hits	142
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

CYLC2_HUMAN
NC score	0.059530 (rank : 1413)	θ value	1.06291 (rank : 785)
Query Neighborhood Hits	1103	Target Neighborhood Hits	223	Shared Neighborhood Hits	52
SwissProt Accessions	Q14093	Gene names	CYLC2, CYL2
Domain Architecture	No domain graphic available
Description	Cylicin-2 (Cylicin II) (Multiple-band polypeptide II).

MYPC3_HUMAN
NC score	0.059495 (rank : 1414)	θ value	θ > 10 (rank : 1504)
Query Neighborhood Hits	1103	Target Neighborhood Hits	318	Shared Neighborhood Hits	65
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

PXK_HUMAN
NC score	0.059485 (rank : 1415)	θ value	θ > 10 (rank : 1600)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	108
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RRBP1_MOUSE
NC score	0.059449 (rank : 1416)	θ value	4.03905 (rank : 971)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1650	Shared Neighborhood Hits	244
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

GOGA1_HUMAN
NC score	0.059421 (rank : 1417)	θ value	θ > 10 (rank : 1359)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1222	Shared Neighborhood Hits	179
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

PTN6_MOUSE
NC score	0.059402 (rank : 1418)	θ value	θ > 10 (rank : 1593)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

CNTN5_MOUSE
NC score	0.059394 (rank : 1419)	θ value	θ > 10 (rank : 1280)
Query Neighborhood Hits	1103	Target Neighborhood Hits	434	Shared Neighborhood Hits	74
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

FLIP1_HUMAN
NC score	0.059389 (rank : 1420)	θ value	θ > 10 (rank : 1348)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1405	Shared Neighborhood Hits	206
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PCNT_MOUSE
NC score	0.059248 (rank : 1421)	θ value	1.38821 (rank : 836)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1207	Shared Neighborhood Hits	167
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

CCD21_MOUSE
NC score	0.059243 (rank : 1422)	θ value	θ > 10 (rank : 1193)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1135	Shared Neighborhood Hits	202
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

IFT81_MOUSE
NC score	0.059209 (rank : 1423)	θ value	θ > 10 (rank : 1404)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	157
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CCD21_HUMAN
NC score	0.059202 (rank : 1424)	θ value	θ > 10 (rank : 1192)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1228	Shared Neighborhood Hits	210
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

SRBS1_MOUSE
NC score	0.059080 (rank : 1425)	θ value	θ > 10 (rank : 1692)
Query Neighborhood Hits	1103	Target Neighborhood Hits	409	Shared Neighborhood Hits	82
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TP53B_MOUSE
NC score	0.059049 (rank : 1426)	θ value	2.36792 (rank : 901)
Query Neighborhood Hits	1103	Target Neighborhood Hits	644	Shared Neighborhood Hits	135
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

HCLS1_MOUSE
NC score	0.059010 (rank : 1427)	θ value	θ > 10 (rank : 1389)
Query Neighborhood Hits	1103	Target Neighborhood Hits	329	Shared Neighborhood Hits	65
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

LRRF1_HUMAN
NC score	0.058990 (rank : 1428)	θ value	θ > 10 (rank : 1458)
Query Neighborhood Hits	1103	Target Neighborhood Hits	625	Shared Neighborhood Hits	150
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

SRC8_HUMAN
NC score	0.058984 (rank : 1429)	θ value	θ > 10 (rank : 1693)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	57
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

NUMA1_HUMAN
NC score	0.058888 (rank : 1430)	θ value	0.279714 (rank : 706)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1523	Shared Neighborhood Hits	192
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

EP15R_MOUSE
NC score	0.058846 (rank : 1431)	θ value	θ > 10 (rank : 1333)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1135	Shared Neighborhood Hits	195
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

CE152_HUMAN
NC score	0.058810 (rank : 1432)	θ value	θ > 10 (rank : 1237)
Query Neighborhood Hits	1103	Target Neighborhood Hits	976	Shared Neighborhood Hits	156
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

BSN_MOUSE
NC score	0.058644 (rank : 1433)	θ value	3.0926 (rank : 906)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2057	Shared Neighborhood Hits	238
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

SRRM2_MOUSE
NC score	0.058554 (rank : 1434)	θ value	θ > 10 (rank : 1697)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1470	Shared Neighborhood Hits	188
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CDON_HUMAN
NC score	0.058496 (rank : 1435)	θ value	θ > 10 (rank : 1235)
Query Neighborhood Hits	1103	Target Neighborhood Hits	412	Shared Neighborhood Hits	60
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NIN_HUMAN
NC score	0.058433 (rank : 1436)	θ value	θ > 10 (rank : 1526)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1416	Shared Neighborhood Hits	193
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

KTN1_MOUSE
NC score	0.058141 (rank : 1437)	θ value	θ > 10 (rank : 1443)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1324	Shared Neighborhood Hits	197
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CNTN3_MOUSE
NC score	0.058028 (rank : 1438)	θ value	θ > 10 (rank : 1276)
Query Neighborhood Hits	1103	Target Neighborhood Hits	447	Shared Neighborhood Hits	73
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CN145_MOUSE
NC score	0.057992 (rank : 1439)	θ value	θ > 10 (rank : 1270)
Query Neighborhood Hits	1103	Target Neighborhood Hits	916	Shared Neighborhood Hits	140
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

SYCP1_MOUSE
NC score	0.057963 (rank : 1440)	θ value	θ > 10 (rank : 1724)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1456	Shared Neighborhood Hits	217
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

FLIP1_MOUSE
NC score	0.057898 (rank : 1441)	θ value	θ > 10 (rank : 1349)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1176	Shared Neighborhood Hits	189
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

HCLS1_HUMAN
NC score	0.057855 (rank : 1442)	θ value	θ > 10 (rank : 1388)
Query Neighborhood Hits	1103	Target Neighborhood Hits	358	Shared Neighborhood Hits	73
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SMC2_HUMAN
NC score	0.057722 (rank : 1443)	θ value	θ > 10 (rank : 1678)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1405	Shared Neighborhood Hits	223
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

BLNK_MOUSE
NC score	0.057671 (rank : 1444)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	1103	Target Neighborhood Hits	296	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SFR12_MOUSE
NC score	0.057668 (rank : 1445)	θ value	0.813845 (rank : 778)
Query Neighborhood Hits	1103	Target Neighborhood Hits	486	Shared Neighborhood Hits	98
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

CNTRB_MOUSE
NC score	0.057608 (rank : 1446)	θ value	θ > 10 (rank : 1283)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1029	Shared Neighborhood Hits	183
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CK5P2_MOUSE
NC score	0.057595 (rank : 1447)	θ value	θ > 10 (rank : 1256)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1151	Shared Neighborhood Hits	195
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

BOC_MOUSE
NC score	0.057559 (rank : 1448)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	1103	Target Neighborhood Hits	433	Shared Neighborhood Hits	75
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

SH3K1_HUMAN
NC score	0.057512 (rank : 1449)	θ value	θ > 10 (rank : 1656)
Query Neighborhood Hits	1103	Target Neighborhood Hits	341	Shared Neighborhood Hits	73
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

MYPN_MOUSE
NC score	0.057460 (rank : 1450)	θ value	θ > 10 (rank : 1507)
Query Neighborhood Hits	1103	Target Neighborhood Hits	421	Shared Neighborhood Hits	62
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

SPTA1_HUMAN
NC score	0.057449 (rank : 1451)	θ value	θ > 10 (rank : 1689)
Query Neighborhood Hits	1103	Target Neighborhood Hits	748	Shared Neighborhood Hits	130
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SMC1A_MOUSE
NC score	0.057445 (rank : 1452)	θ value	θ > 10 (rank : 1677)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1384	Shared Neighborhood Hits	218
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SH3K1_MOUSE
NC score	0.057438 (rank : 1453)	θ value	θ > 10 (rank : 1657)
Query Neighborhood Hits	1103	Target Neighborhood Hits	332	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

TR150_MOUSE
NC score	0.057416 (rank : 1454)	θ value	5.27518 (rank : 1017)
Query Neighborhood Hits	1103	Target Neighborhood Hits	468	Shared Neighborhood Hits	145
SwissProt Accessions	Q569Z6	Gene names	Thrap3, Trap150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

PUNC_MOUSE
NC score	0.057337 (rank : 1455)	θ value	θ > 10 (rank : 1599)
Query Neighborhood Hits	1103	Target Neighborhood Hits	501	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

RBP24_HUMAN
NC score	0.057326 (rank : 1456)	θ value	θ > 10 (rank : 1610)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1559	Shared Neighborhood Hits	207
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

EP15_HUMAN
NC score	0.057299 (rank : 1457)	θ value	0.00509761 (rank : 463)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1021	Shared Neighborhood Hits	146
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MPP10_MOUSE
NC score	0.057215 (rank : 1458)	θ value	1.06291 (rank : 794)
Query Neighborhood Hits	1103	Target Neighborhood Hits	251	Shared Neighborhood Hits	67
SwissProt Accessions	Q810V0	Gene names	Mphosph10
Domain Architecture	No domain graphic available
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

RRBP1_HUMAN
NC score	0.057212 (rank : 1459)	θ value	θ > 10 (rank : 1627)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1306	Shared Neighborhood Hits	207
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

CLSPN_HUMAN
NC score	0.057201 (rank : 1460)	θ value	0.163984 (rank : 667)
Query Neighborhood Hits	1103	Target Neighborhood Hits	433	Shared Neighborhood Hits	102
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

GCC2_HUMAN
NC score	0.057188 (rank : 1461)	θ value	θ > 10 (rank : 1355)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1558	Shared Neighborhood Hits	206
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

EP15R_HUMAN
NC score	0.057136 (rank : 1462)	θ value	θ > 10 (rank : 1332)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1083	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

CNTN4_HUMAN
NC score	0.057045 (rank : 1463)	θ value	θ > 10 (rank : 1277)
Query Neighborhood Hits	1103	Target Neighborhood Hits	449	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

ABI2_HUMAN
NC score	0.056974 (rank : 1464)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	1103	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CCD39_MOUSE
NC score	0.056960 (rank : 1465)	θ value	θ > 10 (rank : 1195)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1026	Shared Neighborhood Hits	156
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

SRC8_MOUSE
NC score	0.056929 (rank : 1466)	θ value	θ > 10 (rank : 1694)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	59
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

BSN_HUMAN
NC score	0.056886 (rank : 1467)	θ value	4.03905 (rank : 952)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1537	Shared Neighborhood Hits	206
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CEP63_HUMAN
NC score	0.056859 (rank : 1468)	θ value	θ > 10 (rank : 1240)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1005	Shared Neighborhood Hits	155
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

RPGR1_MOUSE
NC score	0.056781 (rank : 1469)	θ value	3.0926 (rank : 936)
Query Neighborhood Hits	1103	Target Neighborhood Hits	713	Shared Neighborhood Hits	153
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

EEA1_MOUSE
NC score	0.056700 (rank : 1470)	θ value	θ > 10 (rank : 1331)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1637	Shared Neighborhood Hits	224
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

GAS8_HUMAN
NC score	0.056687 (rank : 1471)	θ value	θ > 10 (rank : 1354)
Query Neighborhood Hits	1103	Target Neighborhood Hits	819	Shared Neighborhood Hits	142
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

OPTN_MOUSE
NC score	0.056655 (rank : 1472)	θ value	θ > 10 (rank : 1537)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1120	Shared Neighborhood Hits	184
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

IFT81_HUMAN
NC score	0.056611 (rank : 1473)	θ value	θ > 10 (rank : 1403)
Query Neighborhood Hits	1103	Target Neighborhood Hits	893	Shared Neighborhood Hits	153
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

SRRM2_HUMAN
NC score	0.056610 (rank : 1474)	θ value	1.06291 (rank : 804)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1296	Shared Neighborhood Hits	167
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

MYPN_HUMAN
NC score	0.056596 (rank : 1475)	θ value	θ > 10 (rank : 1506)
Query Neighborhood Hits	1103	Target Neighborhood Hits	418	Shared Neighborhood Hits	66
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

TRPV2_MOUSE
NC score	0.056472 (rank : 1476)	θ value	θ > 10 (rank : 1754)
Query Neighborhood Hits	1103	Target Neighborhood Hits	111	Shared Neighborhood Hits	82
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

CP135_HUMAN
NC score	0.056402 (rank : 1477)	θ value	θ > 10 (rank : 1284)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1290	Shared Neighborhood Hits	181
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

IF3A_HUMAN
NC score	0.056337 (rank : 1478)	θ value	0.47712 (rank : 742)
Query Neighborhood Hits	1103	Target Neighborhood Hits	875	Shared Neighborhood Hits	143
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

CAF1A_MOUSE
NC score	0.056325 (rank : 1479)	θ value	1.38821 (rank : 814)
Query Neighborhood Hits	1103	Target Neighborhood Hits	736	Shared Neighborhood Hits	130
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

KMHN1_MOUSE
NC score	0.056270 (rank : 1480)	θ value	θ > 10 (rank : 1434)
Query Neighborhood Hits	1103	Target Neighborhood Hits	949	Shared Neighborhood Hits	151
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

KMHN1_HUMAN
NC score	0.056216 (rank : 1481)	θ value	θ > 10 (rank : 1433)
Query Neighborhood Hits	1103	Target Neighborhood Hits	950	Shared Neighborhood Hits	162
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

CNTN4_MOUSE
NC score	0.056181 (rank : 1482)	θ value	θ > 10 (rank : 1278)
Query Neighborhood Hits	1103	Target Neighborhood Hits	445	Shared Neighborhood Hits	70
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

PTN6_HUMAN
NC score	0.056165 (rank : 1483)	θ value	θ > 10 (rank : 1592)
Query Neighborhood Hits	1103	Target Neighborhood Hits	234	Shared Neighborhood Hits	46
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

NIN_MOUSE
NC score	0.056118 (rank : 1484)	θ value	θ > 10 (rank : 1527)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1376	Shared Neighborhood Hits	202
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

RABE1_HUMAN
NC score	0.056053 (rank : 1485)	θ value	θ > 10 (rank : 1602)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1104	Shared Neighborhood Hits	186
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

SDCG8_HUMAN
NC score	0.056024 (rank : 1486)	θ value	θ > 10 (rank : 1632)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1002	Shared Neighborhood Hits	180
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

NCF2_HUMAN
NC score	0.055955 (rank : 1487)	θ value	θ > 10 (rank : 1516)
Query Neighborhood Hits	1103	Target Neighborhood Hits	229	Shared Neighborhood Hits	39
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

TXND2_HUMAN
NC score	0.055949 (rank : 1488)	θ value	8.99809 (rank : 1099)
Query Neighborhood Hits	1103	Target Neighborhood Hits	793	Shared Neighborhood Hits	166
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

MYOTI_HUMAN
NC score	0.055840 (rank : 1489)	θ value	θ > 10 (rank : 1502)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

TAF3_HUMAN
NC score	0.055747 (rank : 1490)	θ value	0.365318 (rank : 734)
Query Neighborhood Hits	1103	Target Neighborhood Hits	568	Shared Neighborhood Hits	110
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

CP250_MOUSE
NC score	0.055743 (rank : 1491)	θ value	θ > 10 (rank : 1287)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1583	Shared Neighborhood Hits	206
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CDON_MOUSE
NC score	0.055730 (rank : 1492)	θ value	θ > 10 (rank : 1236)
Query Neighborhood Hits	1103	Target Neighborhood Hits	410	Shared Neighborhood Hits	61
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

TENS4_MOUSE
NC score	0.055725 (rank : 1493)	θ value	θ > 10 (rank : 1733)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

LIPA1_HUMAN
NC score	0.055667 (rank : 1494)	θ value	θ > 10 (rank : 1453)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1294	Shared Neighborhood Hits	214
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

TAXB1_HUMAN
NC score	0.055461 (rank : 1495)	θ value	θ > 10 (rank : 1729)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	146
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

CCD39_HUMAN
NC score	0.055449 (rank : 1496)	θ value	θ > 10 (rank : 1194)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	148
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CING_HUMAN
NC score	0.055413 (rank : 1497)	θ value	θ > 10 (rank : 1252)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1275	Shared Neighborhood Hits	202
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

FA44A_HUMAN
NC score	0.055358 (rank : 1498)	θ value	0.279714 (rank : 700)
Query Neighborhood Hits	1103	Target Neighborhood Hits	280	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NFC6, Q6P0M8	Gene names	FAM44A
Domain Architecture	No domain graphic available
Description	Protein FAM44A.

TARA_HUMAN
NC score	0.055341 (rank : 1499)	θ value	θ > 10 (rank : 1727)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1626	Shared Neighborhood Hits	245
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MYST3_HUMAN
NC score	0.055340 (rank : 1500)	θ value	0.00665767 (rank : 476)
Query Neighborhood Hits	1103	Target Neighborhood Hits	772	Shared Neighborhood Hits	129
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

MINT_MOUSE
NC score	0.055230 (rank : 1501)	θ value	0.0431538 (rank : 598)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1514	Shared Neighborhood Hits	216
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NOP14_MOUSE
NC score	0.055196 (rank : 1502)	θ value	0.00869519 (rank : 487)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R3N1	Gene names	Nop14
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

IFT74_HUMAN
NC score	0.055141 (rank : 1503)	θ value	θ > 10 (rank : 1402)
Query Neighborhood Hits	1103	Target Neighborhood Hits	949	Shared Neighborhood Hits	145
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

EP15_MOUSE
NC score	0.055069 (rank : 1504)	θ value	0.0431538 (rank : 592)
Query Neighborhood Hits	1103	Target Neighborhood Hits	820	Shared Neighborhood Hits	109
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

TCRG1_MOUSE
NC score	0.055060 (rank : 1505)	θ value	θ > 10 (rank : 1732)
Query Neighborhood Hits	1103	Target Neighborhood Hits	947	Shared Neighborhood Hits	185
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

EEA1_HUMAN
NC score	0.054966 (rank : 1506)	θ value	θ > 10 (rank : 1330)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1796	Shared Neighborhood Hits	219
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

PCLO_MOUSE
NC score	0.054925 (rank : 1507)	θ value	0.00665767 (rank : 479)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2275	Shared Neighborhood Hits	246
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CROCC_MOUSE
NC score	0.054902 (rank : 1508)	θ value	θ > 10 (rank : 1292)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1460	Shared Neighborhood Hits	203
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

RAD50_MOUSE
NC score	0.054661 (rank : 1509)	θ value	θ > 10 (rank : 1605)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1366	Shared Neighborhood Hits	200
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

NCA12_MOUSE
NC score	0.054567 (rank : 1510)	θ value	θ > 10 (rank : 1511)
Query Neighborhood Hits	1103	Target Neighborhood Hits	399	Shared Neighborhood Hits	57
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

TCRG1_HUMAN
NC score	0.054558 (rank : 1511)	θ value	θ > 10 (rank : 1731)
Query Neighborhood Hits	1103	Target Neighborhood Hits	929	Shared Neighborhood Hits	186
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

GON4L_MOUSE
NC score	0.054366 (rank : 1512)	θ value	0.00390308 (rank : 448)
Query Neighborhood Hits	1103	Target Neighborhood Hits	455	Shared Neighborhood Hits	85
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

TACC2_HUMAN
NC score	0.054343 (rank : 1513)	θ value	θ > 10 (rank : 1725)
Query Neighborhood Hits	1103	Target Neighborhood Hits	856	Shared Neighborhood Hits	165
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

SOCS6_MOUSE
NC score	0.054267 (rank : 1514)	θ value	θ > 10 (rank : 1683)
Query Neighborhood Hits	1103	Target Neighborhood Hits	146	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SWP70_MOUSE
NC score	0.054251 (rank : 1515)	θ value	θ > 10 (rank : 1722)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1097	Shared Neighborhood Hits	175
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ERC2_MOUSE
NC score	0.054248 (rank : 1516)	θ value	θ > 10 (rank : 1335)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1166	Shared Neighborhood Hits	171
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

IF3A_MOUSE
NC score	0.054232 (rank : 1517)	θ value	2.36792 (rank : 888)
Query Neighborhood Hits	1103	Target Neighborhood Hits	871	Shared Neighborhood Hits	142
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

CCD91_HUMAN
NC score	0.054193 (rank : 1518)	θ value	θ > 10 (rank : 1199)
Query Neighborhood Hits	1103	Target Neighborhood Hits	868	Shared Neighborhood Hits	168
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

SH22A_HUMAN
NC score	0.054148 (rank : 1519)	θ value	θ > 10 (rank : 1647)
Query Neighborhood Hits	1103	Target Neighborhood Hits	144	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

LAD1_HUMAN
NC score	0.054143 (rank : 1520)	θ value	0.21417 (rank : 684)
Query Neighborhood Hits	1103	Target Neighborhood Hits	441	Shared Neighborhood Hits	97
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

RABE1_MOUSE
NC score	0.054122 (rank : 1521)	θ value	θ > 10 (rank : 1603)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1105	Shared Neighborhood Hits	183
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

CJ118_MOUSE
NC score	0.054118 (rank : 1522)	θ value	θ > 10 (rank : 1254)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1132	Shared Neighborhood Hits	171
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

ABI2_MOUSE
NC score	0.054026 (rank : 1523)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	1103	Target Neighborhood Hits	266	Shared Neighborhood Hits	52
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

RAD50_HUMAN
NC score	0.053979 (rank : 1524)	θ value	θ > 10 (rank : 1604)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1317	Shared Neighborhood Hits	202
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SH3G2_HUMAN
NC score	0.053978 (rank : 1525)	θ value	θ > 10 (rank : 1654)
Query Neighborhood Hits	1103	Target Neighborhood Hits	324	Shared Neighborhood Hits	67
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

LUZP1_MOUSE
NC score	0.053916 (rank : 1526)	θ value	θ > 10 (rank : 1461)
Query Neighborhood Hits	1103	Target Neighborhood Hits	940	Shared Neighborhood Hits	171
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

HMMR_MOUSE
NC score	0.053909 (rank : 1527)	θ value	θ > 10 (rank : 1398)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1178	Shared Neighborhood Hits	174
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

SMC1A_HUMAN
NC score	0.053753 (rank : 1528)	θ value	θ > 10 (rank : 1676)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1346	Shared Neighborhood Hits	210
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

R51A1_MOUSE
NC score	0.053753 (rank : 1529)	θ value	0.0252991 (rank : 565)
Query Neighborhood Hits	1103	Target Neighborhood Hits	164	Shared Neighborhood Hits	54
SwissProt Accessions	Q8C551, O55219, Q8BP36, Q99L94, Q9D0J0	Gene names	Rad51ap1
Domain Architecture	No domain graphic available
Description	RAD51-associated protein 1 (RAD51-interacting protein) (RAB22).

GOGA5_HUMAN
NC score	0.053747 (rank : 1530)	θ value	θ > 10 (rank : 1363)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1168	Shared Neighborhood Hits	177
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

LIPA2_MOUSE
NC score	0.053729 (rank : 1531)	θ value	θ > 10 (rank : 1454)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1282	Shared Neighborhood Hits	215
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

CHL1_HUMAN
NC score	0.053673 (rank : 1532)	θ value	θ > 10 (rank : 1248)
Query Neighborhood Hits	1103	Target Neighborhood Hits	413	Shared Neighborhood Hits	73
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

SDCG8_MOUSE
NC score	0.053643 (rank : 1533)	θ value	θ > 10 (rank : 1633)
Query Neighborhood Hits	1103	Target Neighborhood Hits	886	Shared Neighborhood Hits	174
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

LSAMP_HUMAN
NC score	0.053608 (rank : 1534)	θ value	θ > 10 (rank : 1459)
Query Neighborhood Hits	1103	Target Neighborhood Hits	347	Shared Neighborhood Hits	46
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

SOCS6_HUMAN
NC score	0.053608 (rank : 1535)	θ value	θ > 10 (rank : 1682)
Query Neighborhood Hits	1103	Target Neighborhood Hits	126	Shared Neighborhood Hits	35
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

CI093_HUMAN
NC score	0.053559 (rank : 1536)	θ value	θ > 10 (rank : 1251)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1088	Shared Neighborhood Hits	177
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

LRC45_MOUSE
NC score	0.053444 (rank : 1537)	θ value	θ > 10 (rank : 1457)
Query Neighborhood Hits	1103	Target Neighborhood Hits	959	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

XE7_HUMAN
NC score	0.053431 (rank : 1538)	θ value	θ > 10 (rank : 1795)
Query Neighborhood Hits	1103	Target Neighborhood Hits	738	Shared Neighborhood Hits	127
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

CA065_HUMAN
NC score	0.053266 (rank : 1539)	θ value	4.03905 (rank : 953)
Query Neighborhood Hits	1103	Target Neighborhood Hits	469	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

RP1L1_HUMAN
NC score	0.053214 (rank : 1540)	θ value	0.279714 (rank : 707)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1072	Shared Neighborhood Hits	164
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

BLNK_HUMAN
NC score	0.053205 (rank : 1541)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

KI67_HUMAN
NC score	0.053143 (rank : 1542)	θ value	8.99809 (rank : 1078)
Query Neighborhood Hits	1103	Target Neighborhood Hits	581	Shared Neighborhood Hits	137
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

PHLB1_HUMAN
NC score	0.053041 (rank : 1543)	θ value	6.88961 (rank : 1045)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1038	Shared Neighborhood Hits	166
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

LSAMP_MOUSE
NC score	0.052980 (rank : 1544)	θ value	θ > 10 (rank : 1460)
Query Neighborhood Hits	1103	Target Neighborhood Hits	344	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

AZI1_HUMAN
NC score	0.052955 (rank : 1545)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1000	Shared Neighborhood Hits	157
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BAZ2B_HUMAN
NC score	0.052839 (rank : 1546)	θ value	0.0193708 (rank : 533)
Query Neighborhood Hits	1103	Target Neighborhood Hits	803	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BRE1A_HUMAN
NC score	0.052824 (rank : 1547)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1071	Shared Neighborhood Hits	151
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

CHL1_MOUSE
NC score	0.052808 (rank : 1548)	θ value	θ > 10 (rank : 1249)
Query Neighborhood Hits	1103	Target Neighborhood Hits	402	Shared Neighborhood Hits	69
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN1_MOUSE
NC score	0.052774 (rank : 1549)	θ value	θ > 10 (rank : 1272)
Query Neighborhood Hits	1103	Target Neighborhood Hits	422	Shared Neighborhood Hits	69
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CCD19_HUMAN
NC score	0.052624 (rank : 1550)	θ value	θ > 10 (rank : 1191)
Query Neighborhood Hits	1103	Target Neighborhood Hits	639	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CNTN6_HUMAN
NC score	0.052571 (rank : 1551)	θ value	θ > 10 (rank : 1281)
Query Neighborhood Hits	1103	Target Neighborhood Hits	422	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

GOGA3_MOUSE
NC score	0.052558 (rank : 1552)	θ value	θ > 10 (rank : 1362)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1437	Shared Neighborhood Hits	195
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

ERC2_HUMAN
NC score	0.052529 (rank : 1553)	θ value	θ > 10 (rank : 1334)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1156	Shared Neighborhood Hits	168
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

MYH9_MOUSE
NC score	0.052466 (rank : 1554)	θ value	1.06291 (rank : 795)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1829	Shared Neighborhood Hits	237
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

C8AP2_HUMAN
NC score	0.052432 (rank : 1555)	θ value	θ > 10 (rank : 1189)
Query Neighborhood Hits	1103	Target Neighborhood Hits	548	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

KTN1_HUMAN
NC score	0.052370 (rank : 1556)	θ value	θ > 10 (rank : 1442)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1197	Shared Neighborhood Hits	174
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

MYH9_HUMAN
NC score	0.052229 (rank : 1557)	θ value	0.21417 (rank : 690)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1762	Shared Neighborhood Hits	233
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CCAR1_HUMAN
NC score	0.052223 (rank : 1558)	θ value	0.47712 (rank : 737)
Query Neighborhood Hits	1103	Target Neighborhood Hits	444	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

GOGA3_HUMAN
NC score	0.052150 (rank : 1559)	θ value	θ > 10 (rank : 1361)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1317	Shared Neighborhood Hits	189
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

RBBP8_HUMAN
NC score	0.051977 (rank : 1560)	θ value	2.36792 (rank : 896)
Query Neighborhood Hits	1103	Target Neighborhood Hits	476	Shared Neighborhood Hits	115
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

CNTN1_HUMAN
NC score	0.051944 (rank : 1561)	θ value	θ > 10 (rank : 1271)
Query Neighborhood Hits	1103	Target Neighborhood Hits	431	Shared Neighborhood Hits	69
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

MD1L1_MOUSE
NC score	0.051934 (rank : 1562)	θ value	θ > 10 (rank : 1473)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1001	Shared Neighborhood Hits	153
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

TCAL5_HUMAN
NC score	0.051892 (rank : 1563)	θ value	θ > 10 (rank : 1730)
Query Neighborhood Hits	1103	Target Neighborhood Hits	806	Shared Neighborhood Hits	182
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

CCD55_MOUSE
NC score	0.051797 (rank : 1564)	θ value	8.99809 (rank : 1063)
Query Neighborhood Hits	1103	Target Neighborhood Hits	519	Shared Neighborhood Hits	133
SwissProt Accessions	Q5NCR9	Gene names	Ccdc55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

MYOTI_MOUSE
NC score	0.051709 (rank : 1565)	θ value	θ > 10 (rank : 1503)
Query Neighborhood Hits	1103	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MINT_HUMAN
NC score	0.051695 (rank : 1566)	θ value	5.27518 (rank : 994)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1291	Shared Neighborhood Hits	206
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SM1L2_HUMAN
NC score	0.051628 (rank : 1567)	θ value	θ > 10 (rank : 1675)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1019	Shared Neighborhood Hits	172
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

CYLN2_HUMAN
NC score	0.051508 (rank : 1568)	θ value	θ > 10 (rank : 1302)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1004	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CNTN6_MOUSE
NC score	0.051429 (rank : 1569)	θ value	θ > 10 (rank : 1282)
Query Neighborhood Hits	1103	Target Neighborhood Hits	429	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

MDC1_HUMAN
NC score	0.051369 (rank : 1570)	θ value	θ > 10 (rank : 1474)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1446	Shared Neighborhood Hits	232
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

INVO_MOUSE
NC score	0.051346 (rank : 1571)	θ value	θ > 10 (rank : 1406)
Query Neighborhood Hits	1103	Target Neighborhood Hits	474	Shared Neighborhood Hits	110
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

SH23A_HUMAN
NC score	0.051338 (rank : 1572)	θ value	θ > 10 (rank : 1649)
Query Neighborhood Hits	1103	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SASH1_MOUSE
NC score	0.051280 (rank : 1573)	θ value	θ > 10 (rank : 1631)
Query Neighborhood Hits	1103	Target Neighborhood Hits	263	Shared Neighborhood Hits	70
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

K1383_HUMAN
NC score	0.051275 (rank : 1574)	θ value	0.0563607 (rank : 606)
Query Neighborhood Hits	1103	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2G4, Q58EZ9, Q5VV83	Gene names	KIAA1383
Domain Architecture	No domain graphic available
Description	Protein KIAA1383.

USH2A_MOUSE
NC score	0.051240 (rank : 1575)	θ value	θ > 10 (rank : 1778)
Query Neighborhood Hits	1103	Target Neighborhood Hits	626	Shared Neighborhood Hits	72
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

MPP10_HUMAN
NC score	0.051197 (rank : 1576)	θ value	5.27518 (rank : 997)
Query Neighborhood Hits	1103	Target Neighborhood Hits	306	Shared Neighborhood Hits	85
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

CCHCR_MOUSE
NC score	0.051189 (rank : 1577)	θ value	θ > 10 (rank : 1202)
Query Neighborhood Hits	1103	Target Neighborhood Hits	932	Shared Neighborhood Hits	152
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

TAF3_MOUSE
NC score	0.051181 (rank : 1578)	θ value	3.0926 (rank : 943)
Query Neighborhood Hits	1103	Target Neighborhood Hits	463	Shared Neighborhood Hits	98
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

CCD93_HUMAN
NC score	0.051112 (rank : 1579)	θ value	θ > 10 (rank : 1200)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	118
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

PEPL_HUMAN
NC score	0.051040 (rank : 1580)	θ value	θ > 10 (rank : 1557)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1141	Shared Neighborhood Hits	180
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

HMMR_HUMAN
NC score	0.050961 (rank : 1581)	θ value	θ > 10 (rank : 1397)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1082	Shared Neighborhood Hits	149
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

ITB4_HUMAN
NC score	0.050885 (rank : 1582)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	1103	Target Neighborhood Hits	458	Shared Neighborhood Hits	56
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

CF152_HUMAN
NC score	0.050872 (rank : 1583)	θ value	θ > 10 (rank : 1242)
Query Neighborhood Hits	1103	Target Neighborhood Hits	704	Shared Neighborhood Hits	143
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CENPJ_HUMAN
NC score	0.050865 (rank : 1584)	θ value	θ > 10 (rank : 1238)
Query Neighborhood Hits	1103	Target Neighborhood Hits	721	Shared Neighborhood Hits	165
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

SH3G3_MOUSE
NC score	0.050805 (rank : 1585)	θ value	θ > 10 (rank : 1655)
Query Neighborhood Hits	1103	Target Neighborhood Hits	236	Shared Neighborhood Hits	45
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

HOME2_MOUSE
NC score	0.050765 (rank : 1586)	θ value	θ > 10 (rank : 1399)
Query Neighborhood Hits	1103	Target Neighborhood Hits	882	Shared Neighborhood Hits	164
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

GOGA1_MOUSE
NC score	0.050720 (rank : 1587)	θ value	θ > 10 (rank : 1360)
Query Neighborhood Hits	1103	Target Neighborhood Hits	994	Shared Neighborhood Hits	158
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

BICD2_MOUSE
NC score	0.050587 (rank : 1588)	θ value	1.81305 (rank : 848)
Query Neighborhood Hits	1103	Target Neighborhood Hits	864	Shared Neighborhood Hits	138
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

PEPL_MOUSE
NC score	0.050481 (rank : 1589)	θ value	θ > 10 (rank : 1558)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1105	Shared Neighborhood Hits	177
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

LAD1_MOUSE
NC score	0.050463 (rank : 1590)	θ value	θ > 10 (rank : 1446)
Query Neighborhood Hits	1103	Target Neighborhood Hits	391	Shared Neighborhood Hits	112
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

BRE1A_MOUSE
NC score	0.050219 (rank : 1591)	θ value	θ > 10 (rank : 1184)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1025	Shared Neighborhood Hits	140
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

USH2A_HUMAN
NC score	0.050157 (rank : 1592)	θ value	θ > 10 (rank : 1777)
Query Neighborhood Hits	1103	Target Neighborhood Hits	600	Shared Neighborhood Hits	68
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

RUFY2_HUMAN
NC score	0.050124 (rank : 1593)	θ value	θ > 10 (rank : 1630)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1208	Shared Neighborhood Hits	176
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TACC2_MOUSE
NC score	0.050086 (rank : 1594)	θ value	θ > 10 (rank : 1726)
Query Neighborhood Hits	1103	Target Neighborhood Hits	774	Shared Neighborhood Hits	150
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

CCDC6_HUMAN
NC score	0.050029 (rank : 1595)	θ value	θ > 10 (rank : 1201)
Query Neighborhood Hits	1103	Target Neighborhood Hits	723	Shared Neighborhood Hits	136
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

SRCH_HUMAN
NC score	0.050004 (rank : 1596)	θ value	0.813845 (rank : 779)
Query Neighborhood Hits	1103	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

LRRF1_MOUSE
NC score	0.049901 (rank : 1597)	θ value	1.38821 (rank : 829)
Query Neighborhood Hits	1103	Target Neighborhood Hits	440	Shared Neighborhood Hits	122
SwissProt Accessions	Q3UZ39, O70323, Q3TS94	Gene names	Lrrfip1, Flap
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (FLI-LRR-associated protein 1) (Flap-1) (H186 FLAP).

MYH11_MOUSE
NC score	0.049834 (rank : 1598)	θ value	0.47712 (rank : 747)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1777	Shared Neighborhood Hits	226
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NCOR2_MOUSE
NC score	0.049589 (rank : 1599)	θ value	1.06291 (rank : 797)
Query Neighborhood Hits	1103	Target Neighborhood Hits	790	Shared Neighborhood Hits	151
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

MYH11_HUMAN
NC score	0.049567 (rank : 1600)	θ value	0.279714 (rank : 704)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1806	Shared Neighborhood Hits	234
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CAF1A_HUMAN
NC score	0.049555 (rank : 1601)	θ value	6.88961 (rank : 1025)
Query Neighborhood Hits	1103	Target Neighborhood Hits	750	Shared Neighborhood Hits	125
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CYTSA_HUMAN
NC score	0.049476 (rank : 1602)	θ value	1.38821 (rank : 818)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1138	Shared Neighborhood Hits	186
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

ATRX_HUMAN
NC score	0.049184 (rank : 1603)	θ value	0.813845 (rank : 773)
Query Neighborhood Hits	1103	Target Neighborhood Hits	842	Shared Neighborhood Hits	166
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

HTSF1_MOUSE
NC score	0.048926 (rank : 1604)	θ value	3.0926 (rank : 915)
Query Neighborhood Hits	1103	Target Neighborhood Hits	425	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

CCAR1_MOUSE
NC score	0.048759 (rank : 1605)	θ value	2.36792 (rank : 883)
Query Neighborhood Hits	1103	Target Neighborhood Hits	414	Shared Neighborhood Hits	92
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

CYTSA_MOUSE
NC score	0.048725 (rank : 1606)	θ value	1.38821 (rank : 819)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1104	Shared Neighborhood Hits	181
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

MYH10_HUMAN
NC score	0.048642 (rank : 1607)	θ value	0.163984 (rank : 674)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1620	Shared Neighborhood Hits	210
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CCD82_HUMAN
NC score	0.048562 (rank : 1608)	θ value	0.279714 (rank : 698)
Query Neighborhood Hits	1103	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N4S0, Q9H2Q5, Q9H5E3	Gene names	CCDC82
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 82.

GOGA6_HUMAN
NC score	0.048390 (rank : 1609)	θ value	3.0926 (rank : 914)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1007	Shared Neighborhood Hits	150
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

PELP1_HUMAN
NC score	0.048245 (rank : 1610)	θ value	5.27518 (rank : 1007)
Query Neighborhood Hits	1103	Target Neighborhood Hits	596	Shared Neighborhood Hits	108
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

LRRF2_HUMAN
NC score	0.048136 (rank : 1611)	θ value	3.0926 (rank : 922)
Query Neighborhood Hits	1103	Target Neighborhood Hits	791	Shared Neighborhood Hits	128
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

MYH10_MOUSE
NC score	0.047429 (rank : 1612)	θ value	0.21417 (rank : 689)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1612	Shared Neighborhood Hits	209
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

HTSF1_HUMAN
NC score	0.047301 (rank : 1613)	θ value	1.81305 (rank : 856)
Query Neighborhood Hits	1103	Target Neighborhood Hits	408	Shared Neighborhood Hits	83
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

NFH_MOUSE
NC score	0.046674 (rank : 1614)	θ value	5.27518 (rank : 1003)
Query Neighborhood Hits	1103	Target Neighborhood Hits	2247	Shared Neighborhood Hits	307
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

MYH14_MOUSE
NC score	0.045771 (rank : 1615)	θ value	1.38821 (rank : 834)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1225	Shared Neighborhood Hits	172
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

CENPC_HUMAN
NC score	0.045398 (rank : 1616)	θ value	0.125558 (rank : 651)
Query Neighborhood Hits	1103	Target Neighborhood Hits	147	Shared Neighborhood Hits	51
SwissProt Accessions	Q03188, Q9P0M5	Gene names	CENPC1, CENPC, ICEN7
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C) (Interphase centromere complex protein 7).

NACAM_MOUSE
NC score	0.045353 (rank : 1617)	θ value	1.06291 (rank : 796)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1866	Shared Neighborhood Hits	199
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MYST4_HUMAN
NC score	0.045035 (rank : 1618)	θ value	0.279714 (rank : 705)
Query Neighborhood Hits	1103	Target Neighborhood Hits	671	Shared Neighborhood Hits	132
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

BPAEA_HUMAN
NC score	0.044771 (rank : 1619)	θ value	1.81305 (rank : 849)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1369	Shared Neighborhood Hits	181
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

TRPV4_HUMAN
NC score	0.044770 (rank : 1620)	θ value	4.03905 (rank : 978)
Query Neighborhood Hits	1103	Target Neighborhood Hits	150	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

MYO5C_HUMAN
NC score	0.044717 (rank : 1621)	θ value	2.36792 (rank : 893)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1206	Shared Neighborhood Hits	190
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

T2FA_HUMAN
NC score	0.044454 (rank : 1622)	θ value	8.99809 (rank : 1094)
Query Neighborhood Hits	1103	Target Neighborhood Hits	228	Shared Neighborhood Hits	55
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

CT116_HUMAN
NC score	0.044275 (rank : 1623)	θ value	1.81305 (rank : 853)
Query Neighborhood Hits	1103	Target Neighborhood Hits	294	Shared Neighborhood Hits	64
SwissProt Accessions	Q96HY6, Q9BW47	Gene names	C20orf116
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 precursor.

CT116_MOUSE
NC score	0.044101 (rank : 1624)	θ value	0.47712 (rank : 738)
Query Neighborhood Hits	1103	Target Neighborhood Hits	268	Shared Neighborhood Hits	56
SwissProt Accessions	Q80WW9, Q9CT52	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 homolog precursor.

ATRX_MOUSE
NC score	0.043951 (rank : 1625)	θ value	8.99809 (rank : 1061)
Query Neighborhood Hits	1103	Target Neighborhood Hits	682	Shared Neighborhood Hits	150
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

MYH13_HUMAN
NC score	0.043820 (rank : 1626)	θ value	5.27518 (rank : 999)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1504	Shared Neighborhood Hits	189
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

CKAP4_MOUSE
NC score	0.042969 (rank : 1627)	θ value	1.81305 (rank : 852)
Query Neighborhood Hits	1103	Target Neighborhood Hits	596	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

GON4L_HUMAN
NC score	0.042782 (rank : 1628)	θ value	1.38821 (rank : 822)
Query Neighborhood Hits	1103	Target Neighborhood Hits	555	Shared Neighborhood Hits	111
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

NFM_HUMAN
NC score	0.042542 (rank : 1629)	θ value	0.62314 (rank : 764)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1328	Shared Neighborhood Hits	223
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

T3JAM_HUMAN
NC score	0.042028 (rank : 1630)	θ value	5.27518 (rank : 1016)
Query Neighborhood Hits	1103	Target Neighborhood Hits	533	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

ABTAP_MOUSE
NC score	0.041666 (rank : 1631)	θ value	3.0926 (rank : 902)
Query Neighborhood Hits	1103	Target Neighborhood Hits	381	Shared Neighborhood Hits	92
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

BPA1_MOUSE
NC score	0.041257 (rank : 1632)	θ value	0.813845 (rank : 774)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1477	Shared Neighborhood Hits	191
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CLSPN_MOUSE
NC score	0.041099 (rank : 1633)	θ value	4.03905 (rank : 955)
Query Neighborhood Hits	1103	Target Neighborhood Hits	292	Shared Neighborhood Hits	82
SwissProt Accessions	Q80YR7, Q69GM2	Gene names	Clspn
Domain Architecture	No domain graphic available
Description	Claspin.

NEB1_HUMAN
NC score	0.040430 (rank : 1634)	θ value	5.27518 (rank : 1002)
Query Neighborhood Hits	1103	Target Neighborhood Hits	829	Shared Neighborhood Hits	147
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

AP3B1_HUMAN
NC score	0.040245 (rank : 1635)	θ value	0.0148317 (rank : 511)
Query Neighborhood Hits	1103	Target Neighborhood Hits	283	Shared Neighborhood Hits	53
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

PLEC1_HUMAN
NC score	0.040054 (rank : 1636)	θ value	4.03905 (rank : 969)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1326	Shared Neighborhood Hits	161
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

NFM_MOUSE
NC score	0.039746 (rank : 1637)	θ value	4.03905 (rank : 963)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1159	Shared Neighborhood Hits	203
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

TR150_HUMAN
NC score	0.039743 (rank : 1638)	θ value	1.38821 (rank : 842)
Query Neighborhood Hits	1103	Target Neighborhood Hits	313	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TRPV4_MOUSE
NC score	0.039294 (rank : 1639)	θ value	8.99809 (rank : 1097)
Query Neighborhood Hits	1103	Target Neighborhood Hits	117	Shared Neighborhood Hits	66
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

BAZ1A_HUMAN
NC score	0.039189 (rank : 1640)	θ value	4.03905 (rank : 951)
Query Neighborhood Hits	1103	Target Neighborhood Hits	693	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

DEK_HUMAN
NC score	0.038862 (rank : 1641)	θ value	3.0926 (rank : 910)
Query Neighborhood Hits	1103	Target Neighborhood Hits	199	Shared Neighborhood Hits	55
SwissProt Accessions	P35659, Q5TGV4, Q5TGV5	Gene names	DEK
Domain Architecture	No domain graphic available
Description	Protein DEK.

ZRAB2_HUMAN
NC score	0.038553 (rank : 1642)	θ value	3.0926 (rank : 947)
Query Neighborhood Hits	1103	Target Neighborhood Hits	120	Shared Neighborhood Hits	29
SwissProt Accessions	O95218, Q9UP63	Gene names	ZRANB2, ZIS, ZNF265
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 2 Zinc finger protein 265 (Zinc finger, splicing).

BPTF_HUMAN
NC score	0.037568 (rank : 1643)	θ value	3.0926 (rank : 905)
Query Neighborhood Hits	1103	Target Neighborhood Hits	786	Shared Neighborhood Hits	150
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

NKTR_HUMAN
NC score	0.037452 (rank : 1644)	θ value	0.21417 (rank : 692)
Query Neighborhood Hits	1103	Target Neighborhood Hits	658	Shared Neighborhood Hits	150
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

NFH_HUMAN
NC score	0.037174 (rank : 1645)	θ value	6.88961 (rank : 1042)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1242	Shared Neighborhood Hits	202
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

BAT2_HUMAN
NC score	0.037160 (rank : 1646)	θ value	4.03905 (rank : 950)
Query Neighborhood Hits	1103	Target Neighborhood Hits	931	Shared Neighborhood Hits	108
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

TCOF_HUMAN
NC score	0.037060 (rank : 1647)	θ value	1.06291 (rank : 806)
Query Neighborhood Hits	1103	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

KIF4A_MOUSE
NC score	0.036615 (rank : 1648)	θ value	6.88961 (rank : 1035)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1033	Shared Neighborhood Hits	172
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KINH_MOUSE
NC score	0.036421 (rank : 1649)	θ value	4.03905 (rank : 957)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1082	Shared Neighborhood Hits	178
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

TPM2_HUMAN
NC score	0.035967 (rank : 1650)	θ value	8.99809 (rank : 1096)
Query Neighborhood Hits	1103	Target Neighborhood Hits	677	Shared Neighborhood Hits	96
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

DNMT1_HUMAN
NC score	0.035880 (rank : 1651)	θ value	5.27518 (rank : 986)
Query Neighborhood Hits	1103	Target Neighborhood Hits	401	Shared Neighborhood Hits	111
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

PELP1_MOUSE
NC score	0.035638 (rank : 1652)	θ value	1.38821 (rank : 837)
Query Neighborhood Hits	1103	Target Neighborhood Hits	709	Shared Neighborhood Hits	106
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

EP300_HUMAN
NC score	0.035109 (rank : 1653)	θ value	0.0431538 (rank : 593)
Query Neighborhood Hits	1103	Target Neighborhood Hits	821	Shared Neighborhood Hits	98
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

NCOR1_HUMAN
NC score	0.034049 (rank : 1654)	θ value	2.36792 (rank : 894)
Query Neighborhood Hits	1103	Target Neighborhood Hits	577	Shared Neighborhood Hits	119
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

ICAL_MOUSE
NC score	0.033794 (rank : 1655)	θ value	1.06291 (rank : 789)
Query Neighborhood Hits	1103	Target Neighborhood Hits	178	Shared Neighborhood Hits	45
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

MYO6_HUMAN
NC score	0.032849 (rank : 1656)	θ value	1.81305 (rank : 867)
Query Neighborhood Hits	1103	Target Neighborhood Hits	727	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

BAT2_MOUSE
NC score	0.032497 (rank : 1657)	θ value	0.47712 (rank : 736)
Query Neighborhood Hits	1103	Target Neighborhood Hits	947	Shared Neighborhood Hits	106
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

RBM5_HUMAN
NC score	0.032001 (rank : 1658)	θ value	0.0193708 (rank : 550)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	16
SwissProt Accessions	P52756, Q93021, Q9BU14, Q9UKY8, Q9UL24	Gene names	RBM5
Domain Architecture
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15) (Protein G15) (NY-REN-9 antigen).

RBM5_MOUSE
NC score	0.031863 (rank : 1659)	θ value	0.0330416 (rank : 583)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	19
SwissProt Accessions	Q91YE7, Q3UZ19, Q99KV9	Gene names	Rbm5, Luca15
Domain Architecture	No domain graphic available
Description	RNA-binding protein 5 (RNA-binding motif protein 5) (Tumor suppressor LUCA15).

PRG4_HUMAN
NC score	0.031538 (rank : 1660)	θ value	0.62314 (rank : 766)
Query Neighborhood Hits	1103	Target Neighborhood Hits	764	Shared Neighborhood Hits	98
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ARS2_HUMAN
NC score	0.030517 (rank : 1661)	θ value	2.36792 (rank : 880)
Query Neighborhood Hits	1103	Target Neighborhood Hits	186	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

SEC62_HUMAN
NC score	0.030470 (rank : 1662)	θ value	1.06291 (rank : 803)
Query Neighborhood Hits	1103	Target Neighborhood Hits	100	Shared Neighborhood Hits	23
SwissProt Accessions	Q99442, O00682, O00729	Gene names	TLOC1, SEC62
Domain Architecture	No domain graphic available
Description	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1).

C8AP2_MOUSE
NC score	0.030285 (rank : 1663)	θ value	6.88961 (rank : 1024)
Query Neighborhood Hits	1103	Target Neighborhood Hits	405	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

SETD2_HUMAN
NC score	0.029989 (rank : 1664)	θ value	3.0926 (rank : 939)
Query Neighborhood Hits	1103	Target Neighborhood Hits	412	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

XRCC1_HUMAN
NC score	0.029816 (rank : 1665)	θ value	1.06291 (rank : 808)
Query Neighborhood Hits	1103	Target Neighborhood Hits	131	Shared Neighborhood Hits	44
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

RHG25_HUMAN
NC score	0.029566 (rank : 1666)	θ value	0.365318 (rank : 730)
Query Neighborhood Hits	1103	Target Neighborhood Hits	550	Shared Neighborhood Hits	93
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ARS2_MOUSE
NC score	0.028919 (rank : 1667)	θ value	4.03905 (rank : 949)
Query Neighborhood Hits	1103	Target Neighborhood Hits	212	Shared Neighborhood Hits	49
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

NCOR1_MOUSE
NC score	0.028679 (rank : 1668)	θ value	6.88961 (rank : 1041)
Query Neighborhood Hits	1103	Target Neighborhood Hits	521	Shared Neighborhood Hits	104
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

PDXL2_MOUSE
NC score	0.028587 (rank : 1669)	θ value	3.0926 (rank : 932)
Query Neighborhood Hits	1103	Target Neighborhood Hits	213	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

WDR60_HUMAN
NC score	0.028273 (rank : 1670)	θ value	8.99809 (rank : 1101)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WVS4, Q9NW58	Gene names	WDR60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

MYO6_MOUSE
NC score	0.028150 (rank : 1671)	θ value	6.88961 (rank : 1039)
Query Neighborhood Hits	1103	Target Neighborhood Hits	586	Shared Neighborhood Hits	103
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

K0408_HUMAN
NC score	0.028071 (rank : 1672)	θ value	1.38821 (rank : 826)
Query Neighborhood Hits	1103	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZU52, O43158, Q5TF20, Q7L2M2	Gene names	KIAA0408
Domain Architecture	No domain graphic available
Description	Protein KIAA0408.

FBX38_HUMAN
NC score	0.028051 (rank : 1673)	θ value	0.47712 (rank : 741)
Query Neighborhood Hits	1103	Target Neighborhood Hits	141	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PIJ6, Q6PK72, Q7Z2U0, Q86VN3, Q9BXY6, Q9H837, Q9HC40	Gene names	FBXO38
Domain Architecture	No domain graphic available
Description	F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA).

HDAC5_HUMAN
NC score	0.028034 (rank : 1674)	θ value	0.0736092 (rank : 624)
Query Neighborhood Hits	1103	Target Neighborhood Hits	353	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

WDR43_HUMAN
NC score	0.027587 (rank : 1675)	θ value	0.0431538 (rank : 602)
Query Neighborhood Hits	1103	Target Neighborhood Hits	269	Shared Neighborhood Hits	28
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

AFF4_MOUSE
NC score	0.026834 (rank : 1676)	θ value	8.99809 (rank : 1060)
Query Neighborhood Hits	1103	Target Neighborhood Hits	581	Shared Neighborhood Hits	108
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

MYT1L_HUMAN
NC score	0.026479 (rank : 1677)	θ value	8.99809 (rank : 1080)
Query Neighborhood Hits	1103	Target Neighborhood Hits	471	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

AP3B2_HUMAN
NC score	0.026121 (rank : 1678)	θ value	1.81305 (rank : 846)
Query Neighborhood Hits	1103	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	Q13367, O14808	Gene names	AP3B2
Domain Architecture
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (AP-3 complex beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP).

MAP2_HUMAN
NC score	0.025992 (rank : 1679)	θ value	1.81305 (rank : 859)
Query Neighborhood Hits	1103	Target Neighborhood Hits	348	Shared Neighborhood Hits	78
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

MCES_HUMAN
NC score	0.025901 (rank : 1680)	θ value	0.47712 (rank : 746)
Query Neighborhood Hits	1103	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

RERE_MOUSE
NC score	0.025611 (rank : 1681)	θ value	8.99809 (rank : 1087)
Query Neighborhood Hits	1103	Target Neighborhood Hits	785	Shared Neighborhood Hits	97
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

WIRE_HUMAN
NC score	0.025225 (rank : 1682)	θ value	3.0926 (rank : 945)
Query Neighborhood Hits	1103	Target Neighborhood Hits	329	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

RTN4_HUMAN
NC score	0.024995 (rank : 1683)	θ value	8.99809 (rank : 1088)
Query Neighborhood Hits	1103	Target Neighborhood Hits	357	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

RTN1_HUMAN
NC score	0.024959 (rank : 1684)	θ value	0.125558 (rank : 659)
Query Neighborhood Hits	1103	Target Neighborhood Hits	173	Shared Neighborhood Hits	29
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

HRX_HUMAN
NC score	0.024787 (rank : 1685)	θ value	1.81305 (rank : 854)
Query Neighborhood Hits	1103	Target Neighborhood Hits	825	Shared Neighborhood Hits	111
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

SMRC2_HUMAN
NC score	0.024654 (rank : 1686)	θ value	6.88961 (rank : 1052)
Query Neighborhood Hits	1103	Target Neighborhood Hits	499	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

RERE_HUMAN
NC score	0.024590 (rank : 1687)	θ value	6.88961 (rank : 1047)
Query Neighborhood Hits	1103	Target Neighborhood Hits	779	Shared Neighborhood Hits	112
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

TSKS_HUMAN
NC score	0.023757 (rank : 1688)	θ value	8.99809 (rank : 1098)
Query Neighborhood Hits	1103	Target Neighborhood Hits	220	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UJT2, Q8WXJ0	Gene names	STK22S1, TSKS, TSKS1
Domain Architecture	No domain graphic available
Description	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1).

MYT1L_MOUSE
NC score	0.023273 (rank : 1689)	θ value	8.99809 (rank : 1081)
Query Neighborhood Hits	1103	Target Neighborhood Hits	461	Shared Neighborhood Hits	90
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

DPOD3_HUMAN
NC score	0.023239 (rank : 1690)	θ value	2.36792 (rank : 886)
Query Neighborhood Hits	1103	Target Neighborhood Hits	109	Shared Neighborhood Hits	36
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

FYB_HUMAN
NC score	0.022923 (rank : 1691)	θ value	8.99809 (rank : 1071)
Query Neighborhood Hits	1103	Target Neighborhood Hits	379	Shared Neighborhood Hits	67
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

TXD13_HUMAN
NC score	0.022859 (rank : 1692)	θ value	0.47712 (rank : 752)
Query Neighborhood Hits	1103	Target Neighborhood Hits	106	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H1E5, Q8N4P7, Q8NCC1, Q9UJA1, Q9ULQ8	Gene names	TXNDC13, KIAA1162
Domain Architecture
Description	Thioredoxin domain-containing protein 13 precursor.

NFYC_HUMAN
NC score	0.022689 (rank : 1693)	θ value	0.21417 (rank : 691)
Query Neighborhood Hits	1103	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q13952, Q5T6K8, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7	Gene names	NFYC
Domain Architecture
Description	Nuclear transcription factor Y subunit gamma (Nuclear transcription factor Y subunit C) (NF-YC) (CAAT-box DNA-binding protein subunit C) (Transactivator HSM-1/2).

AN32B_MOUSE
NC score	0.022610 (rank : 1694)	θ value	1.06291 (rank : 781)
Query Neighborhood Hits	1103	Target Neighborhood Hits	236	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

NFL_MOUSE
NC score	0.022406 (rank : 1695)	θ value	1.06291 (rank : 798)
Query Neighborhood Hits	1103	Target Neighborhood Hits	695	Shared Neighborhood Hits	127
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

PESC_HUMAN
NC score	0.022211 (rank : 1696)	θ value	0.62314 (rank : 765)
Query Neighborhood Hits	1103	Target Neighborhood Hits	90	Shared Neighborhood Hits	24
SwissProt Accessions	O00541, Q6IC29	Gene names	PES1
Domain Architecture
Description	Pescadillo homolog 1.

SURF6_HUMAN
NC score	0.022144 (rank : 1697)	θ value	3.0926 (rank : 942)
Query Neighborhood Hits	1103	Target Neighborhood Hits	104	Shared Neighborhood Hits	26
SwissProt Accessions	O75683, Q9BRK9, Q9BTZ5, Q9UK24	Gene names	SURF6, SURF-6
Domain Architecture
Description	Surfeit locus protein 6.

HDAC5_MOUSE
NC score	0.022023 (rank : 1698)	θ value	0.62314 (rank : 759)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

SFPQ_HUMAN
NC score	0.021818 (rank : 1699)	θ value	6.88961 (rank : 1049)
Query Neighborhood Hits	1103	Target Neighborhood Hits	986	Shared Neighborhood Hits	121
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

BRD2_HUMAN
NC score	0.021734 (rank : 1700)	θ value	0.279714 (rank : 697)
Query Neighborhood Hits	1103	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

WIRE_MOUSE
NC score	0.021142 (rank : 1701)	θ value	8.99809 (rank : 1102)
Query Neighborhood Hits	1103	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

RTN1_MOUSE
NC score	0.021142 (rank : 1702)	θ value	3.0926 (rank : 938)
Query Neighborhood Hits	1103	Target Neighborhood Hits	189	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

DMRTA_MOUSE
NC score	0.021095 (rank : 1703)	θ value	0.279714 (rank : 699)
Query Neighborhood Hits	1103	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFG4	Gene names	Dmrta1, Dmrt4
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor A1 (Doublesex- and mab-3-related transcription factor 4).

CASC3_HUMAN
NC score	0.020976 (rank : 1704)	θ value	5.27518 (rank : 984)
Query Neighborhood Hits	1103	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	O15234	Gene names	CASC3, MLN51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node protein 51) (Protein MLN 51) (Protein barentsz) (Btz).

KIF3A_MOUSE
NC score	0.020729 (rank : 1705)	θ value	3.0926 (rank : 920)
Query Neighborhood Hits	1103	Target Neighborhood Hits	715	Shared Neighborhood Hits	120
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

TOIP2_HUMAN
NC score	0.020688 (rank : 1706)	θ value	1.38821 (rank : 841)
Query Neighborhood Hits	1103	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NFQ8	Gene names	TOR1AIP2, LULL1
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1).

TOPRS_HUMAN
NC score	0.020566 (rank : 1707)	θ value	0.279714 (rank : 709)
Query Neighborhood Hits	1103	Target Neighborhood Hits	286	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

ZCHC6_MOUSE
NC score	0.020439 (rank : 1708)	θ value	0.0961366 (rank : 648)
Query Neighborhood Hits	1103	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q5BLK4, Q8CIH3	Gene names	Zcchc6
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

NADAP_HUMAN
NC score	0.020200 (rank : 1709)	θ value	4.03905 (rank : 962)
Query Neighborhood Hits	1103	Target Neighborhood Hits	208	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

SPTB1_HUMAN
NC score	0.020059 (rank : 1710)	θ value	5.27518 (rank : 1012)
Query Neighborhood Hits	1103	Target Neighborhood Hits	541	Shared Neighborhood Hits	95
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

DAXX_MOUSE
NC score	0.020021 (rank : 1711)	θ value	8.99809 (rank : 1067)
Query Neighborhood Hits	1103	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

SIAL_HUMAN
NC score	0.019979 (rank : 1712)	θ value	6.88961 (rank : 1050)
Query Neighborhood Hits	1103	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	P21815	Gene names	IBSP, BNSP
Domain Architecture
Description	Bone sialoprotein-2 precursor (Bone sialoprotein II) (BSP II) (Cell- binding sialoprotein) (Integrin-binding sialoprotein).

ARI1A_HUMAN
NC score	0.019956 (rank : 1713)	θ value	2.36792 (rank : 879)
Query Neighborhood Hits	1103	Target Neighborhood Hits	787	Shared Neighborhood Hits	78
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

BCL9_HUMAN
NC score	0.019945 (rank : 1714)	θ value	8.99809 (rank : 1062)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1008	Shared Neighborhood Hits	100
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

PDXL2_HUMAN
NC score	0.019699 (rank : 1715)	θ value	4.03905 (rank : 966)
Query Neighborhood Hits	1103	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZ53, Q6UVY4, Q8WUV6	Gene names	PODXL2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

SFPQ_MOUSE
NC score	0.019398 (rank : 1716)	θ value	8.99809 (rank : 1089)
Query Neighborhood Hits	1103	Target Neighborhood Hits	958	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

FBX38_MOUSE
NC score	0.019014 (rank : 1717)	θ value	5.27518 (rank : 989)
Query Neighborhood Hits	1103	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BMI0, Q8BTQ4, Q8C0H4	Gene names	Fbxo38
Domain Architecture	No domain graphic available
Description	F-box only protein 38 (Modulator of KLF7 activity) (MoKA).

NCOA7_MOUSE
NC score	0.018922 (rank : 1718)	θ value	1.38821 (rank : 835)
Query Neighborhood Hits	1103	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

NCKX1_HUMAN
NC score	0.018891 (rank : 1719)	θ value	5.27518 (rank : 1001)
Query Neighborhood Hits	1103	Target Neighborhood Hits	223	Shared Neighborhood Hits	45
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

OS9_HUMAN
NC score	0.018809 (rank : 1720)	θ value	5.27518 (rank : 1006)
Query Neighborhood Hits	1103	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

GBP2_HUMAN
NC score	0.018756 (rank : 1721)	θ value	5.27518 (rank : 990)
Query Neighborhood Hits	1103	Target Neighborhood Hits	349	Shared Neighborhood Hits	73
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

RRMJ3_HUMAN
NC score	0.018479 (rank : 1722)	θ value	3.0926 (rank : 937)
Query Neighborhood Hits	1103	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6	Gene names	FTSJ3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

MORC1_HUMAN
NC score	0.017952 (rank : 1723)	θ value	1.81305 (rank : 863)
Query Neighborhood Hits	1103	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q86VD1, Q7L8E2, Q9NSG7, Q9Y6D4	Gene names	MORC1, MORC
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 1.

SELPL_MOUSE
NC score	0.017923 (rank : 1724)	θ value	6.88961 (rank : 1048)
Query Neighborhood Hits	1103	Target Neighborhood Hits	588	Shared Neighborhood Hits	80
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

PODXL_HUMAN
NC score	0.017486 (rank : 1725)	θ value	1.81305 (rank : 874)
Query Neighborhood Hits	1103	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	O00592	Gene names	PODXL, PCLP, PCLP1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

TRI44_HUMAN
NC score	0.017206 (rank : 1726)	θ value	4.03905 (rank : 977)
Query Neighborhood Hits	1103	Target Neighborhood Hits	393	Shared Neighborhood Hits	64
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

MIA2_MOUSE
NC score	0.017121 (rank : 1727)	θ value	4.03905 (rank : 959)
Query Neighborhood Hits	1103	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

AN32E_HUMAN
NC score	0.016803 (rank : 1728)	θ value	1.81305 (rank : 845)
Query Neighborhood Hits	1103	Target Neighborhood Hits	291	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

LRCH2_HUMAN
NC score	0.016064 (rank : 1729)	θ value	0.125558 (rank : 655)
Query Neighborhood Hits	1103	Target Neighborhood Hits	315	Shared Neighborhood Hits	23
SwissProt Accessions	Q5VUJ6, Q9HA88, Q9P233	Gene names	LRCH2, KIAA1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

NRDC_MOUSE
NC score	0.016033 (rank : 1730)	θ value	3.0926 (rank : 929)
Query Neighborhood Hits	1103	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

DNL1_HUMAN
NC score	0.015782 (rank : 1731)	θ value	6.88961 (rank : 1029)
Query Neighborhood Hits	1103	Target Neighborhood Hits	216	Shared Neighborhood Hits	48
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

SYNPO_HUMAN
NC score	0.015752 (rank : 1732)	θ value	4.03905 (rank : 975)
Query Neighborhood Hits	1103	Target Neighborhood Hits	281	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

DHX16_HUMAN
NC score	0.015641 (rank : 1733)	θ value	2.36792 (rank : 884)
Query Neighborhood Hits	1103	Target Neighborhood Hits	356	Shared Neighborhood Hits	90
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

NRDC_HUMAN
NC score	0.015552 (rank : 1734)	θ value	3.0926 (rank : 928)
Query Neighborhood Hits	1103	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

HS90A_MOUSE
NC score	0.015358 (rank : 1735)	θ value	1.81305 (rank : 855)
Query Neighborhood Hits	1103	Target Neighborhood Hits	155	Shared Neighborhood Hits	37
SwissProt Accessions	P07901	Gene names	Hsp90aa1, Hsp86, Hsp86-1, Hspca
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (Tumor-specific transplantation 86 kDa antigen) (TSTA).

TROAP_HUMAN
NC score	0.015011 (rank : 1736)	θ value	5.27518 (rank : 1018)
Query Neighborhood Hits	1103	Target Neighborhood Hits	258	Shared Neighborhood Hits	31
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

CNGA1_HUMAN
NC score	0.014602 (rank : 1737)	θ value	1.38821 (rank : 815)
Query Neighborhood Hits	1103	Target Neighborhood Hits	149	Shared Neighborhood Hits	31
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

AN32E_MOUSE
NC score	0.014390 (rank : 1738)	θ value	3.0926 (rank : 903)
Query Neighborhood Hits	1103	Target Neighborhood Hits	257	Shared Neighborhood Hits	20
SwissProt Accessions	P97822, Q3TH89, Q8BPF8, Q8C2L4, Q8C7Q8, Q9CZD2	Gene names	Anp32e, Cpd1
Domain Architecture
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L) (Cerebellar postnatal development protein 1).

HS90A_HUMAN
NC score	0.014045 (rank : 1739)	θ value	6.88961 (rank : 1032)
Query Neighborhood Hits	1103	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	P07900, Q2PP14, Q9BVQ5	Gene names	HSP90AA1, HSP90A, HSPC1, HSPCA
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (NY-REN-38 antigen).

PARD3_HUMAN
NC score	0.013840 (rank : 1740)	θ value	1.81305 (rank : 873)
Query Neighborhood Hits	1103	Target Neighborhood Hits	312	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

COG2_HUMAN
NC score	0.013565 (rank : 1741)	θ value	1.38821 (rank : 816)
Query Neighborhood Hits	1103	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q14746	Gene names	COG2, LDLC
Domain Architecture
Description	Conserved oligomeric Golgi complex component 2 (Low density lipoprotein receptor defect C-complementing protein).

OSBL5_MOUSE
NC score	0.013519 (rank : 1742)	θ value	6.88961 (rank : 1043)
Query Neighborhood Hits	1103	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

ARI3A_MOUSE
NC score	0.012792 (rank : 1743)	θ value	6.88961 (rank : 1023)
Query Neighborhood Hits	1103	Target Neighborhood Hits	64	Shared Neighborhood Hits	15
SwissProt Accessions	Q62431	Gene names	Arid3a, Dri1, Dril1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (Dead ringer-like protein 1) (B-cell regulator of IgH transcription) (Bright).

SH3BG_MOUSE
NC score	0.012304 (rank : 1744)	θ value	4.03905 (rank : 973)
Query Neighborhood Hits	1103	Target Neighborhood Hits	99	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WUZ7	Gene names	Sh3bgr
Domain Architecture
Description	SH3 domain-binding glutamic acid-rich protein (SH3BGR protein).

TTC15_MOUSE
NC score	0.012212 (rank : 1745)	θ value	5.27518 (rank : 1019)
Query Neighborhood Hits	1103	Target Neighborhood Hits	113	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K2L8, Q8BX27	Gene names	Ttc15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

XPC_HUMAN
NC score	0.011324 (rank : 1746)	θ value	6.88961 (rank : 1057)
Query Neighborhood Hits	1103	Target Neighborhood Hits	64	Shared Neighborhood Hits	18
SwissProt Accessions	Q01831, Q96AX0	Gene names	XPC, XPCC
Domain Architecture
Description	DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125).

LRCH2_MOUSE
NC score	0.011224 (rank : 1747)	θ value	0.62314 (rank : 763)
Query Neighborhood Hits	1103	Target Neighborhood Hits	287	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UMG5, Q7TNP9, Q80TC9	Gene names	Lrch2, Kiaa1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

TCAL4_HUMAN
NC score	0.010763 (rank : 1748)	θ value	4.03905 (rank : 976)
Query Neighborhood Hits	1103	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96EI5, Q8WY12, Q9H2H1, Q9H775	Gene names	TCEAL4
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 4 (TCEA-like protein 4) (Transcription elongation factor S-II protein-like 4).

CNGA1_MOUSE
NC score	0.010574 (rank : 1749)	θ value	8.99809 (rank : 1066)
Query Neighborhood Hits	1103	Target Neighborhood Hits	198	Shared Neighborhood Hits	35
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

MELPH_MOUSE
NC score	0.010068 (rank : 1750)	θ value	3.0926 (rank : 924)
Query Neighborhood Hits	1103	Target Neighborhood Hits	112	Shared Neighborhood Hits	20
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

FANCJ_HUMAN
NC score	0.009949 (rank : 1751)	θ value	3.0926 (rank : 911)
Query Neighborhood Hits	1103	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BX63, Q8NCI5	Gene names	BRIP1, BACH1, FANCJ
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

ZYX_MOUSE
NC score	0.009742 (rank : 1752)	θ value	5.27518 (rank : 1022)
Query Neighborhood Hits	1103	Target Neighborhood Hits	347	Shared Neighborhood Hits	29
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

ARHGB_HUMAN
NC score	0.009708 (rank : 1753)	θ value	2.36792 (rank : 878)
Query Neighborhood Hits	1103	Target Neighborhood Hits	375	Shared Neighborhood Hits	42
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

MIER1_HUMAN
NC score	0.009478 (rank : 1754)	θ value	6.88961 (rank : 1036)
Query Neighborhood Hits	1103	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N108, Q5T104, Q6AHY8, Q86TB4, Q8N156, Q8N161, Q8NC37, Q8NES4, Q8NES5, Q8NES6, Q8WWG2, Q9HCG2	Gene names	MIER1, KIAA1610
Domain Architecture	No domain graphic available
Description	Mesoderm induction early response protein 1 (Mi-er1) (hmi-er1) (Early response 1) (Er1).

GPTC3_HUMAN
NC score	0.009152 (rank : 1755)	θ value	6.88961 (rank : 1031)
Query Neighborhood Hits	1103	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q96I76, Q5JYH2, Q8NDJ2, Q9H9Z3	Gene names	GPATC3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

NOG2_HUMAN
NC score	0.009031 (rank : 1756)	θ value	8.99809 (rank : 1083)
Query Neighborhood Hits	1103	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

CHD9_MOUSE
NC score	0.008696 (rank : 1757)	θ value	8.99809 (rank : 1065)
Query Neighborhood Hits	1103	Target Neighborhood Hits	427	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

INGR1_HUMAN
NC score	0.008345 (rank : 1758)	θ value	4.03905 (rank : 956)
Query Neighborhood Hits	1103	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P15260	Gene names	IFNGR1
Domain Architecture
Description	Interferon-gamma receptor alpha chain precursor (IFN-gamma-R1) (CD119 antigen) (CDw119).

FBX30_MOUSE
NC score	0.008305 (rank : 1759)	θ value	3.0926 (rank : 912)
Query Neighborhood Hits	1103	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BJL1, Q8CI21, Q9D9X5	Gene names	Fbxo30
Domain Architecture
Description	F-box only protein 30.

HUWE1_HUMAN
NC score	0.008243 (rank : 1760)	θ value	8.99809 (rank : 1073)
Query Neighborhood Hits	1103	Target Neighborhood Hits	443	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

KCNH6_HUMAN
NC score	0.008048 (rank : 1761)	θ value	5.27518 (rank : 993)
Query Neighborhood Hits	1103	Target Neighborhood Hits	222	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

APBB2_MOUSE
NC score	0.007854 (rank : 1762)	θ value	2.36792 (rank : 877)
Query Neighborhood Hits	1103	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

GLMN_HUMAN
NC score	0.007714 (rank : 1763)	θ value	5.27518 (rank : 991)
Query Neighborhood Hits	1103	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q92990, Q9BVE8	Gene names	GLMN, FAP48, VMGLOM
Domain Architecture	No domain graphic available
Description	Glomulin (FKBP-associated protein) (FK506-binding protein-associated protein) (FAP).

T22D3_HUMAN
NC score	0.007537 (rank : 1764)	θ value	5.27518 (rank : 1015)
Query Neighborhood Hits	1103	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q99576, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5, Q9UG13	Gene names	TSC22D3, DSIPI, GILZ
Domain Architecture
Description	TSC22 domain family protein 3 (Glucocorticoid-induced leucine zipper protein) (Delta sleep-inducing peptide immunoreactor) (DSIP- immunoreactive peptide) (Protein DIP) (hDIP) (TSC-22-like protein) (TSC-22R).

ESCO2_HUMAN
NC score	0.007241 (rank : 1765)	θ value	5.27518 (rank : 988)
Query Neighborhood Hits	1103	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q56NI9	Gene names	ESCO2
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2).

RYR2_HUMAN
NC score	0.006942 (rank : 1766)	θ value	4.03905 (rank : 972)
Query Neighborhood Hits	1103	Target Neighborhood Hits	175	Shared Neighborhood Hits	24
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

GRIP1_HUMAN
NC score	0.006462 (rank : 1767)	θ value	8.99809 (rank : 1072)
Query Neighborhood Hits	1103	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

SSRP1_MOUSE
NC score	0.006461 (rank : 1768)	θ value	6.88961 (rank : 1054)
Query Neighborhood Hits	1103	Target Neighborhood Hits	193	Shared Neighborhood Hits	34
SwissProt Accessions	Q08943, Q3U9Z2, Q3UJ75, Q4V9U4, Q8CGA6	Gene names	Ssrp1
Domain Architecture
Description	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Structure-specific recognition protein 1) (Recombination signal sequence recognition protein 1) (T160).

SIRT1_HUMAN
NC score	0.006164 (rank : 1769)	θ value	6.88961 (rank : 1051)
Query Neighborhood Hits	1103	Target Neighborhood Hits	44	Shared Neighborhood Hits	11
SwissProt Accessions	Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0	Gene names	SIRT1, SIR2L1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (hSIRT1) (hSIR2) (SIR2-like protein 1).

EPN1_MOUSE
NC score	0.005962 (rank : 1770)	θ value	6.88961 (rank : 1030)
Query Neighborhood Hits	1103	Target Neighborhood Hits	240	Shared Neighborhood Hits	31
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

TIM_HUMAN
NC score	0.005846 (rank : 1771)	θ value	8.99809 (rank : 1095)
Query Neighborhood Hits	1103	Target Neighborhood Hits	40	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UNS1, O94802, Q86VM1, Q8IWH3	Gene names	TIMELESS, TIM, TIM1, TIMELESS1
Domain Architecture	No domain graphic available
Description	Timeless homolog (hTIM).

ZF106_HUMAN
NC score	0.005239 (rank : 1772)	θ value	8.99809 (rank : 1103)
Query Neighborhood Hits	1103	Target Neighborhood Hits	470	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

IDI1_MOUSE
NC score	0.004461 (rank : 1773)	θ value	8.99809 (rank : 1074)
Query Neighborhood Hits	1103	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P58044	Gene names	Idi1
Domain Architecture
Description	Isopentenyl-diphosphate delta-isomerase 1 (EC 5.3.3.2) (IPP isomerase 1) (Isopentenyl pyrophosphate isomerase 1) (IPPI1).

DLGP2_MOUSE
NC score	0.004396 (rank : 1774)	θ value	8.99809 (rank : 1069)
Query Neighborhood Hits	1103	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BJ42, Q6XBF3	Gene names	Dlgap2, Dap2
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 2 (DAP-2) (SAP90/PSD-95-associated protein 2) (SAPAP2) (PSD-95/SAP90-binding protein 2).

E41L1_HUMAN
NC score	0.004243 (rank : 1775)	θ value	5.27518 (rank : 987)
Query Neighborhood Hits	1103	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

MTMR3_HUMAN
NC score	0.004068 (rank : 1776)	θ value	5.27518 (rank : 998)
Query Neighborhood Hits	1103	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

GNDS_HUMAN
NC score	0.004047 (rank : 1777)	θ value	3.0926 (rank : 913)
Query Neighborhood Hits	1103	Target Neighborhood Hits	201	Shared Neighborhood Hits	20
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

CDC27_HUMAN
NC score	0.003633 (rank : 1778)	θ value	3.0926 (rank : 909)
Query Neighborhood Hits	1103	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

DC1I1_MOUSE
NC score	0.002916 (rank : 1779)	θ value	8.99809 (rank : 1068)
Query Neighborhood Hits	1103	Target Neighborhood Hits	206	Shared Neighborhood Hits	23
SwissProt Accessions	O88485, O88486	Gene names	Dync1i1, Dnci1, Dncic1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

JHD1B_MOUSE
NC score	0.002630 (rank : 1780)	θ value	8.99809 (rank : 1076)
Query Neighborhood Hits	1103	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

TCEA3_HUMAN
NC score	0.002000 (rank : 1781)	θ value	6.88961 (rank : 1055)
Query Neighborhood Hits	1103	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	O75764	Gene names	TCEA3, TFIISH
Domain Architecture
Description	Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h).

PKNX2_HUMAN
NC score	-0.000154 (rank : 1782)	θ value	4.03905 (rank : 968)
Query Neighborhood Hits	1103	Target Neighborhood Hits	133	Shared Neighborhood Hits	6
SwissProt Accessions	Q96KN3, Q63HL6, Q86XD1	Gene names	PKNOX2, PREP2
Domain Architecture
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

STA13_MOUSE
NC score	-0.000593 (rank : 1783)	θ value	5.27518 (rank : 1014)
Query Neighborhood Hits	1103	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CAC1F_MOUSE
NC score	-0.001037 (rank : 1784)	θ value	2.36792 (rank : 882)
Query Neighborhood Hits	1103	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

NAL13_HUMAN
NC score	-0.001242 (rank : 1785)	θ value	6.88961 (rank : 1040)
Query Neighborhood Hits	1103	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

INHBA_HUMAN
NC score	-0.002012 (rank : 1786)	θ value	3.0926 (rank : 917)
Query Neighborhood Hits	1103	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P08476, Q14599	Gene names	INHBA
Domain Architecture
Description	Inhibin beta A chain precursor (Activin beta-A chain) (Erythroid differentiation protein) (EDF).

AT2B3_HUMAN
NC score	-0.003208 (rank : 1787)	θ value	5.27518 (rank : 983)
Query Neighborhood Hits	1103	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q16720, Q12995, Q16858	Gene names	ATP2B3
Domain Architecture
Description	Plasma membrane calcium-transporting ATPase 3 (EC 3.6.3.8) (PMCA3) (Plasma membrane calcium pump isoform 3) (Plasma membrane calcium ATPase isoform 3).

ARX_MOUSE
NC score	-0.010271 (rank : 1788)	θ value	2.36792 (rank : 881)
Query Neighborhood Hits	1103	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

ARX_HUMAN
NC score	-0.010510 (rank : 1789)	θ value	3.0926 (rank : 904)
Query Neighborhood Hits	1103	Target Neighborhood Hits	401	Shared Neighborhood Hits	13
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

TCF8_HUMAN
NC score	-0.011902 (rank : 1790)	θ value	0.00869519 (rank : 488)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1057	Shared Neighborhood Hits	82
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

TCF8_MOUSE
NC score	-0.012912 (rank : 1791)	θ value	1.81305 (rank : 875)
Query Neighborhood Hits	1103	Target Neighborhood Hits	1067	Shared Neighborhood Hits	83
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZFP91_HUMAN
NC score	-0.018785 (rank : 1792)	θ value	1.38821 (rank : 844)
Query Neighborhood Hits	1103	Target Neighborhood Hits	769	Shared Neighborhood Hits	26
SwissProt Accessions	Q96JP5, Q86V47, Q96JP4, Q96QA3	Gene names	ZFP91
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 homolog (Zfp-91).

ZFP91_MOUSE
NC score	-0.020005 (rank : 1793)	θ value	5.27518 (rank : 1020)
Query Neighborhood Hits	1103	Target Neighborhood Hits	742	Shared Neighborhood Hits	20
SwissProt Accessions	Q62511, Q8BPY3, Q8C2B4	Gene names	Zfp91, Pzf
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 (Zfp-91) (Zinc finger protein PZF) (Penta Zf protein).

ZN496_HUMAN
NC score	-0.021470 (rank : 1794)	θ value	5.27518 (rank : 1021)
Query Neighborhood Hits	1103	Target Neighborhood Hits	743	Shared Neighborhood Hits	16
SwissProt Accessions	Q96IT1	Gene names	ZNF496
Domain Architecture	No domain graphic available
Description	Zinc finger protein 496.

ZBT17_HUMAN
NC score	-0.023241 (rank : 1795)	θ value	6.88961 (rank : 1058)
Query Neighborhood Hits	1103	Target Neighborhood Hits	925	Shared Neighborhood Hits	37
SwissProt Accessions	Q13105, Q15932, Q5JYB2, Q9NUC9	Gene names	ZBTB17, MIZ1, ZNF151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Myc-interacting zinc finger protein) (Miz-1 protein).