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Network neighborhood for query Sequence : TENS4_MOUSE

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TENS4_MOUSE
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TENS4_HUMAN
θ value	0 (rank : 1)	NC score	0.933118 (rank : 2)
Query Neighborhood Hits	225	Target Neighborhood Hits	214	Shared Neighborhood Hits	103
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	225	Target Neighborhood Hits	225	Shared Neighborhood Hits	225
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS1_HUMAN
θ value	5.50685e-82 (rank : 3)	NC score	0.627888 (rank : 3)
Query Neighborhood Hits	225	Target Neighborhood Hits	400	Shared Neighborhood Hits	84
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CSK_MOUSE
θ value	0.000270298 (rank : 4)	NC score	0.115774 (rank : 62)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	89
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
θ value	0.000602161 (rank : 5)	NC score	0.114752 (rank : 63)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	89
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

RIN1_HUMAN
θ value	0.00102713 (rank : 6)	NC score	0.166924 (rank : 28)
Query Neighborhood Hits	225	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13671, O15010, Q00427, Q96CC8	Gene names	RIN1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1) (Ras inhibitor JC99).

TXK_MOUSE
θ value	0.00102713 (rank : 7)	NC score	0.113437 (rank : 64)
Query Neighborhood Hits	225	Target Neighborhood Hits	980	Shared Neighborhood Hits	84
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TXK_HUMAN
θ value	0.00228821 (rank : 8)	NC score	0.110818 (rank : 68)
Query Neighborhood Hits	225	Target Neighborhood Hits	971	Shared Neighborhood Hits	84
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BTK_HUMAN
θ value	0.00509761 (rank : 9)	NC score	0.112781 (rank : 65)
Query Neighborhood Hits	225	Target Neighborhood Hits	1026	Shared Neighborhood Hits	80
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

TEC_MOUSE
θ value	0.00509761 (rank : 10)	NC score	0.104635 (rank : 75)
Query Neighborhood Hits	225	Target Neighborhood Hits	1006	Shared Neighborhood Hits	75
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

GRAP2_HUMAN
θ value	0.00869519 (rank : 11)	NC score	0.216159 (rank : 6)
Query Neighborhood Hits	225	Target Neighborhood Hits	304	Shared Neighborhood Hits	81
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

P85B_HUMAN
θ value	0.00869519 (rank : 12)	NC score	0.194479 (rank : 13)
Query Neighborhood Hits	225	Target Neighborhood Hits	543	Shared Neighborhood Hits	84
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TRI66_HUMAN
θ value	0.0113563 (rank : 13)	NC score	0.059653 (rank : 217)
Query Neighborhood Hits	225	Target Neighborhood Hits	479	Shared Neighborhood Hits	33
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

SLAP2_HUMAN
θ value	0.0148317 (rank : 14)	NC score	0.247988 (rank : 5)
Query Neighborhood Hits	225	Target Neighborhood Hits	139	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

BTK_MOUSE
θ value	0.0193708 (rank : 15)	NC score	0.111080 (rank : 67)
Query Neighborhood Hits	225	Target Neighborhood Hits	1017	Shared Neighborhood Hits	80
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

GRAP2_MOUSE
θ value	0.0252991 (rank : 16)	NC score	0.210775 (rank : 8)
Query Neighborhood Hits	225	Target Neighborhood Hits	297	Shared Neighborhood Hits	80
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PTN11_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.121515 (rank : 57)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.0252991 (rank : 18)	NC score	0.121529 (rank : 56)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RIN1_MOUSE
θ value	0.0252991 (rank : 19)	NC score	0.134012 (rank : 48)
Query Neighborhood Hits	225	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

SLAP2_MOUSE
θ value	0.0330416 (rank : 20)	NC score	0.248516 (rank : 4)
Query Neighborhood Hits	225	Target Neighborhood Hits	136	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

TEC_HUMAN
θ value	0.0330416 (rank : 21)	NC score	0.105403 (rank : 74)
Query Neighborhood Hits	225	Target Neighborhood Hits	1006	Shared Neighborhood Hits	78
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VAV2_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.137526 (rank : 45)
Query Neighborhood Hits	225	Target Neighborhood Hits	453	Shared Neighborhood Hits	81
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CTND2_HUMAN
θ value	0.0431538 (rank : 23)	NC score	0.042044 (rank : 375)
Query Neighborhood Hits	225	Target Neighborhood Hits	333	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

GRB14_MOUSE
θ value	0.0431538 (rank : 24)	NC score	0.172975 (rank : 23)
Query Neighborhood Hits	225	Target Neighborhood Hits	149	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SH24A_MOUSE
θ value	0.0431538 (rank : 25)	NC score	0.170987 (rank : 24)
Query Neighborhood Hits	225	Target Neighborhood Hits	326	Shared Neighborhood Hits	60
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

BLK_MOUSE
θ value	0.0563607 (rank : 26)	NC score	0.107452 (rank : 73)
Query Neighborhood Hits	225	Target Neighborhood Hits	992	Shared Neighborhood Hits	88
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MILK2_HUMAN
θ value	0.0736092 (rank : 27)	NC score	0.047135 (rank : 366)
Query Neighborhood Hits	225	Target Neighborhood Hits	457	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MNT_MOUSE
θ value	0.0736092 (rank : 28)	NC score	0.083934 (rank : 130)
Query Neighborhood Hits	225	Target Neighborhood Hits	432	Shared Neighborhood Hits	36
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NCA11_MOUSE
θ value	0.0736092 (rank : 29)	NC score	0.022535 (rank : 427)
Query Neighborhood Hits	225	Target Neighborhood Hits	661	Shared Neighborhood Hits	28
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

WASF1_HUMAN
θ value	0.0736092 (rank : 30)	NC score	0.066415 (rank : 173)
Query Neighborhood Hits	225	Target Neighborhood Hits	260	Shared Neighborhood Hits	29
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

CS016_HUMAN
θ value	0.0961366 (rank : 31)	NC score	0.098533 (rank : 103)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	37
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

P55G_MOUSE
θ value	0.0961366 (rank : 32)	NC score	0.198003 (rank : 12)
Query Neighborhood Hits	225	Target Neighborhood Hits	401	Shared Neighborhood Hits	73
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

POGZ_HUMAN
θ value	0.0961366 (rank : 33)	NC score	0.019605 (rank : 435)
Query Neighborhood Hits	225	Target Neighborhood Hits	745	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3K3, O75049, Q8TDZ7, Q9Y4X7	Gene names	POGZ, KIAA0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

SAPS1_HUMAN
θ value	0.0961366 (rank : 34)	NC score	0.064374 (rank : 178)
Query Neighborhood Hits	225	Target Neighborhood Hits	704	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

VAV2_MOUSE
θ value	0.0961366 (rank : 35)	NC score	0.135328 (rank : 47)
Query Neighborhood Hits	225	Target Neighborhood Hits	456	Shared Neighborhood Hits	81
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CRK_HUMAN
θ value	0.125558 (rank : 36)	NC score	0.203013 (rank : 9)
Query Neighborhood Hits	225	Target Neighborhood Hits	308	Shared Neighborhood Hits	86
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.125558 (rank : 37)	NC score	0.200922 (rank : 10)
Query Neighborhood Hits	225	Target Neighborhood Hits	314	Shared Neighborhood Hits	86
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

BCAR1_HUMAN
θ value	0.163984 (rank : 38)	NC score	0.068768 (rank : 159)
Query Neighborhood Hits	225	Target Neighborhood Hits	554	Shared Neighborhood Hits	77
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HSH2D_HUMAN
θ value	0.163984 (rank : 39)	NC score	0.215247 (rank : 7)
Query Neighborhood Hits	225	Target Neighborhood Hits	159	Shared Neighborhood Hits	75
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CBP_HUMAN
θ value	0.21417 (rank : 40)	NC score	0.072022 (rank : 151)
Query Neighborhood Hits	225	Target Neighborhood Hits	941	Shared Neighborhood Hits	70
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

FOXL2_HUMAN
θ value	0.21417 (rank : 41)	NC score	0.023598 (rank : 423)
Query Neighborhood Hits	225	Target Neighborhood Hits	142	Shared Neighborhood Hits	7
SwissProt Accessions	P58012, Q4ZGJ3	Gene names	FOXL2
Domain Architecture
Description	Forkhead box protein L2.

FOXL2_MOUSE
θ value	0.21417 (rank : 42)	NC score	0.024718 (rank : 418)
Query Neighborhood Hits	225	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	O88470, Q8K3X9	Gene names	Foxl2, Pfrk
Domain Architecture	No domain graphic available
Description	Forkhead box protein L2 (Pituitary forkhead factor) (P-Frk).

GSCR1_HUMAN
θ value	0.21417 (rank : 43)	NC score	0.075492 (rank : 143)
Query Neighborhood Hits	225	Target Neighborhood Hits	674	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HSH2D_MOUSE
θ value	0.21417 (rank : 44)	NC score	0.199219 (rank : 11)
Query Neighborhood Hits	225	Target Neighborhood Hits	124	Shared Neighborhood Hits	62
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LYN_MOUSE
θ value	0.21417 (rank : 45)	NC score	0.103601 (rank : 80)
Query Neighborhood Hits	225	Target Neighborhood Hits	1023	Shared Neighborhood Hits	87
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MNT_HUMAN
θ value	0.21417 (rank : 46)	NC score	0.073686 (rank : 147)
Query Neighborhood Hits	225	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

ABL2_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.104286 (rank : 78)
Query Neighborhood Hits	225	Target Neighborhood Hits	1045	Shared Neighborhood Hits	97
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

BLK_HUMAN
θ value	0.279714 (rank : 48)	NC score	0.101918 (rank : 92)
Query Neighborhood Hits	225	Target Neighborhood Hits	994	Shared Neighborhood Hits	82
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

K0310_HUMAN
θ value	0.279714 (rank : 49)	NC score	0.075401 (rank : 144)
Query Neighborhood Hits	225	Target Neighborhood Hits	420	Shared Neighborhood Hits	57
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

P85A_MOUSE
θ value	0.279714 (rank : 50)	NC score	0.165886 (rank : 29)
Query Neighborhood Hits	225	Target Neighborhood Hits	435	Shared Neighborhood Hits	76
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CRKL_MOUSE
θ value	0.365318 (rank : 51)	NC score	0.188403 (rank : 19)
Query Neighborhood Hits	225	Target Neighborhood Hits	307	Shared Neighborhood Hits	82
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SRMS_HUMAN
θ value	0.365318 (rank : 52)	NC score	0.104507 (rank : 77)
Query Neighborhood Hits	225	Target Neighborhood Hits	946	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

WASF1_MOUSE
θ value	0.365318 (rank : 53)	NC score	0.060470 (rank : 201)
Query Neighborhood Hits	225	Target Neighborhood Hits	261	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

CUTL1_HUMAN
θ value	0.47712 (rank : 54)	NC score	0.023684 (rank : 421)
Query Neighborhood Hits	225	Target Neighborhood Hits	1574	Shared Neighborhood Hits	43
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

GRB10_MOUSE
θ value	0.47712 (rank : 55)	NC score	0.140028 (rank : 43)
Query Neighborhood Hits	225	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

LYN_HUMAN
θ value	0.47712 (rank : 56)	NC score	0.102113 (rank : 90)
Query Neighborhood Hits	225	Target Neighborhood Hits	1022	Shared Neighborhood Hits	86
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NPAS4_MOUSE
θ value	0.47712 (rank : 57)	NC score	0.055168 (rank : 302)
Query Neighborhood Hits	225	Target Neighborhood Hits	245	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

P55G_HUMAN
θ value	0.47712 (rank : 58)	NC score	0.191663 (rank : 14)
Query Neighborhood Hits	225	Target Neighborhood Hits	451	Shared Neighborhood Hits	75
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

RIN2_MOUSE
θ value	0.47712 (rank : 59)	NC score	0.102910 (rank : 85)
Query Neighborhood Hits	225	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

SOCS3_HUMAN
θ value	0.47712 (rank : 60)	NC score	0.140686 (rank : 42)
Query Neighborhood Hits	225	Target Neighborhood Hits	77	Shared Neighborhood Hits	45
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	0.47712 (rank : 61)	NC score	0.143061 (rank : 36)
Query Neighborhood Hits	225	Target Neighborhood Hits	72	Shared Neighborhood Hits	45
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

WNK2_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.048871 (rank : 362)
Query Neighborhood Hits	225	Target Neighborhood Hits	1407	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZBTB4_HUMAN
θ value	0.47712 (rank : 63)	NC score	0.011245 (rank : 455)
Query Neighborhood Hits	225	Target Neighborhood Hits	926	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

DDFL1_HUMAN
θ value	0.62314 (rank : 64)	NC score	0.026509 (rank : 408)
Query Neighborhood Hits	225	Target Neighborhood Hits	353	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

GRB10_HUMAN
θ value	0.62314 (rank : 65)	NC score	0.139031 (rank : 44)
Query Neighborhood Hits	225	Target Neighborhood Hits	147	Shared Neighborhood Hits	72
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

PAF49_MOUSE
θ value	0.62314 (rank : 66)	NC score	0.050137 (rank : 358)
Query Neighborhood Hits	225	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q76KJ5, Q8K0Y9	Gene names	Cd3eap, Ase1, Paf49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein).

PER3_HUMAN
θ value	0.62314 (rank : 67)	NC score	0.041293 (rank : 376)
Query Neighborhood Hits	225	Target Neighborhood Hits	479	Shared Neighborhood Hits	46
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

RASA1_HUMAN
θ value	0.62314 (rank : 68)	NC score	0.144879 (rank : 33)
Query Neighborhood Hits	225	Target Neighborhood Hits	258	Shared Neighborhood Hits	78
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SC24C_HUMAN
θ value	0.62314 (rank : 69)	NC score	0.072195 (rank : 149)
Query Neighborhood Hits	225	Target Neighborhood Hits	662	Shared Neighborhood Hits	62
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SH24A_HUMAN
θ value	0.62314 (rank : 70)	NC score	0.141040 (rank : 41)
Query Neighborhood Hits	225	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHB_MOUSE
θ value	0.62314 (rank : 71)	NC score	0.142947 (rank : 37)
Query Neighborhood Hits	225	Target Neighborhood Hits	137	Shared Neighborhood Hits	72
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SRMS_MOUSE
θ value	0.62314 (rank : 72)	NC score	0.100239 (rank : 97)
Query Neighborhood Hits	225	Target Neighborhood Hits	964	Shared Neighborhood Hits	87
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BMX_HUMAN
θ value	0.813845 (rank : 73)	NC score	0.097146 (rank : 110)
Query Neighborhood Hits	225	Target Neighborhood Hits	942	Shared Neighborhood Hits	84
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CNOT3_HUMAN
θ value	0.813845 (rank : 74)	NC score	0.049785 (rank : 360)
Query Neighborhood Hits	225	Target Neighborhood Hits	425	Shared Neighborhood Hits	32
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CUTL1_MOUSE
θ value	0.813845 (rank : 75)	NC score	0.025587 (rank : 414)
Query Neighborhood Hits	225	Target Neighborhood Hits	1620	Shared Neighborhood Hits	52
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

ENAH_MOUSE
θ value	0.813845 (rank : 76)	NC score	0.051928 (rank : 342)
Query Neighborhood Hits	225	Target Neighborhood Hits	919	Shared Neighborhood Hits	59
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

FGR_MOUSE
θ value	0.813845 (rank : 77)	NC score	0.110240 (rank : 70)
Query Neighborhood Hits	225	Target Neighborhood Hits	1069	Shared Neighborhood Hits	93
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RGNEF_MOUSE
θ value	0.813845 (rank : 78)	NC score	0.027948 (rank : 405)
Query Neighborhood Hits	225	Target Neighborhood Hits	641	Shared Neighborhood Hits	19
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RTN1_MOUSE
θ value	0.813845 (rank : 79)	NC score	0.040300 (rank : 380)
Query Neighborhood Hits	225	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SHE_MOUSE
θ value	0.813845 (rank : 80)	NC score	0.160877 (rank : 30)
Query Neighborhood Hits	225	Target Neighborhood Hits	169	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

CAF1B_HUMAN
θ value	1.06291 (rank : 81)	NC score	0.015312 (rank : 445)
Query Neighborhood Hits	225	Target Neighborhood Hits	345	Shared Neighborhood Hits	9
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

CD2L5_HUMAN
θ value	1.06291 (rank : 82)	NC score	0.036232 (rank : 386)
Query Neighborhood Hits	225	Target Neighborhood Hits	987	Shared Neighborhood Hits	49
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CRKL_HUMAN
θ value	1.06291 (rank : 83)	NC score	0.183061 (rank : 20)
Query Neighborhood Hits	225	Target Neighborhood Hits	313	Shared Neighborhood Hits	81
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DAB1_MOUSE
θ value	1.06291 (rank : 84)	NC score	0.042595 (rank : 372)
Query Neighborhood Hits	225	Target Neighborhood Hits	145	Shared Neighborhood Hits	14
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

KLF17_HUMAN
θ value	1.06291 (rank : 85)	NC score	0.007237 (rank : 463)
Query Neighborhood Hits	225	Target Neighborhood Hits	882	Shared Neighborhood Hits	41
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

P85B_MOUSE
θ value	1.06291 (rank : 86)	NC score	0.178080 (rank : 21)
Query Neighborhood Hits	225	Target Neighborhood Hits	519	Shared Neighborhood Hits	84
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PRG4_HUMAN
θ value	1.06291 (rank : 87)	NC score	0.057710 (rank : 256)
Query Neighborhood Hits	225	Target Neighborhood Hits	764	Shared Neighborhood Hits	48
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RGS3_MOUSE
θ value	1.06291 (rank : 88)	NC score	0.069580 (rank : 157)
Query Neighborhood Hits	225	Target Neighborhood Hits	1621	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SET1A_HUMAN
θ value	1.06291 (rank : 89)	NC score	0.034406 (rank : 389)
Query Neighborhood Hits	225	Target Neighborhood Hits	690	Shared Neighborhood Hits	37
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SHB_HUMAN
θ value	1.06291 (rank : 90)	NC score	0.141265 (rank : 40)
Query Neighborhood Hits	225	Target Neighborhood Hits	141	Shared Neighborhood Hits	74
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

BLNK_MOUSE
θ value	1.38821 (rank : 91)	NC score	0.103077 (rank : 84)
Query Neighborhood Hits	225	Target Neighborhood Hits	296	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

EP400_HUMAN
θ value	1.38821 (rank : 92)	NC score	0.034453 (rank : 388)
Query Neighborhood Hits	225	Target Neighborhood Hits	556	Shared Neighborhood Hits	40
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

EPN4_MOUSE
θ value	1.38821 (rank : 93)	NC score	0.026389 (rank : 409)
Query Neighborhood Hits	225	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KN9, Q8CFH4	Gene names	Clint1, Enth, Epn4, Epnr, Kiaa0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin).

GLIS1_HUMAN
θ value	1.38821 (rank : 94)	NC score	0.002779 (rank : 468)
Query Neighborhood Hits	225	Target Neighborhood Hits	748	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

RGS3_HUMAN
θ value	1.38821 (rank : 95)	NC score	0.049198 (rank : 361)
Query Neighborhood Hits	225	Target Neighborhood Hits	1375	Shared Neighborhood Hits	88
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RTN4_HUMAN
θ value	1.38821 (rank : 96)	NC score	0.041252 (rank : 377)
Query Neighborhood Hits	225	Target Neighborhood Hits	357	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

RXRA_HUMAN
θ value	1.38821 (rank : 97)	NC score	0.010124 (rank : 458)
Query Neighborhood Hits	225	Target Neighborhood Hits	223	Shared Neighborhood Hits	19
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

ZN687_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.011236 (rank : 456)
Query Neighborhood Hits	225	Target Neighborhood Hits	913	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

BMX_MOUSE
θ value	1.81305 (rank : 99)	NC score	0.096488 (rank : 112)
Query Neighborhood Hits	225	Target Neighborhood Hits	912	Shared Neighborhood Hits	84
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BSN_MOUSE
θ value	1.81305 (rank : 100)	NC score	0.085345 (rank : 129)
Query Neighborhood Hits	225	Target Neighborhood Hits	2057	Shared Neighborhood Hits	113
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CBP_MOUSE
θ value	1.81305 (rank : 101)	NC score	0.077118 (rank : 140)
Query Neighborhood Hits	225	Target Neighborhood Hits	1051	Shared Neighborhood Hits	87
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CSKI2_MOUSE
θ value	1.81305 (rank : 102)	NC score	0.028300 (rank : 404)
Query Neighborhood Hits	225	Target Neighborhood Hits	812	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSTF2_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.018011 (rank : 440)
Query Neighborhood Hits	225	Target Neighborhood Hits	296	Shared Neighborhood Hits	12
SwissProt Accessions	P33240, Q5H951, Q6LA74, Q8N502	Gene names	CSTF2
Domain Architecture
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

DDR1_HUMAN
θ value	1.81305 (rank : 104)	NC score	0.067913 (rank : 165)
Query Neighborhood Hits	225	Target Neighborhood Hits	819	Shared Neighborhood Hits	45
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EP400_MOUSE
θ value	1.81305 (rank : 105)	NC score	0.034860 (rank : 387)
Query Neighborhood Hits	225	Target Neighborhood Hits	592	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

GRB2_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.188928 (rank : 15)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	81
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	1.81305 (rank : 107)	NC score	0.188900 (rank : 16)
Query Neighborhood Hits	225	Target Neighborhood Hits	312	Shared Neighborhood Hits	81
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HNRPG_HUMAN
θ value	1.81305 (rank : 108)	NC score	0.020697 (rank : 431)
Query Neighborhood Hits	225	Target Neighborhood Hits	245	Shared Neighborhood Hits	9
SwissProt Accessions	P38159, Q5JQ67, Q969R3	Gene names	RBMX, HNRPG, RBMXP1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome) (Glycoprotein p43).

HNRPG_MOUSE
θ value	1.81305 (rank : 109)	NC score	0.021519 (rank : 429)
Query Neighborhood Hits	225	Target Neighborhood Hits	223	Shared Neighborhood Hits	7
SwissProt Accessions	O35479	Gene names	Rbmx, Hnrnpg, Hnrpg, Rbmxp1, Rbmxrt
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome).

LNK_MOUSE
θ value	1.81305 (rank : 110)	NC score	0.141368 (rank : 39)
Query Neighborhood Hits	225	Target Neighborhood Hits	132	Shared Neighborhood Hits	62
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MAGE1_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.066693 (rank : 171)
Query Neighborhood Hits	225	Target Neighborhood Hits	1389	Shared Neighborhood Hits	96
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

P85A_HUMAN
θ value	1.81305 (rank : 112)	NC score	0.158956 (rank : 31)
Query Neighborhood Hits	225	Target Neighborhood Hits	479	Shared Neighborhood Hits	75
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

POGZ_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.016254 (rank : 443)
Query Neighborhood Hits	225	Target Neighborhood Hits	765	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZH4, Q4VA94, Q80TZ8, Q8C0K1, Q8K294	Gene names	Pogz, Kiaa0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

SRC_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.101331 (rank : 93)
Query Neighborhood Hits	225	Target Neighborhood Hits	1058	Shared Neighborhood Hits	90
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.102461 (rank : 87)
Query Neighborhood Hits	225	Target Neighborhood Hits	1033	Shared Neighborhood Hits	90
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ANKS1_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.018478 (rank : 438)
Query Neighborhood Hits	225	Target Neighborhood Hits	438	Shared Neighborhood Hits	15
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	2.36792 (rank : 117)	NC score	0.020408 (rank : 433)
Query Neighborhood Hits	225	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ATX2L_HUMAN
θ value	2.36792 (rank : 118)	NC score	0.039196 (rank : 381)
Query Neighborhood Hits	225	Target Neighborhood Hits	443	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

CSKI1_MOUSE
θ value	2.36792 (rank : 119)	NC score	0.028698 (rank : 403)
Query Neighborhood Hits	225	Target Neighborhood Hits	1031	Shared Neighborhood Hits	72
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

HCK_HUMAN
θ value	2.36792 (rank : 120)	NC score	0.102140 (rank : 89)
Query Neighborhood Hits	225	Target Neighborhood Hits	1035	Shared Neighborhood Hits	90
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ITK_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.099153 (rank : 101)
Query Neighborhood Hits	225	Target Neighborhood Hits	1016	Shared Neighborhood Hits	86
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	2.36792 (rank : 122)	NC score	0.099115 (rank : 102)
Query Neighborhood Hits	225	Target Neighborhood Hits	985	Shared Neighborhood Hits	85
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

MATK_HUMAN
θ value	2.36792 (rank : 123)	NC score	0.097895 (rank : 106)
Query Neighborhood Hits	225	Target Neighborhood Hits	954	Shared Neighborhood Hits	87
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

NHS_HUMAN
θ value	2.36792 (rank : 124)	NC score	0.046316 (rank : 368)
Query Neighborhood Hits	225	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

PININ_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.028711 (rank : 402)
Query Neighborhood Hits	225	Target Neighborhood Hits	753	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PLCG1_HUMAN
θ value	2.36792 (rank : 126)	NC score	0.143074 (rank : 35)
Query Neighborhood Hits	225	Target Neighborhood Hits	293	Shared Neighborhood Hits	81
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	2.36792 (rank : 127)	NC score	0.142091 (rank : 38)
Query Neighborhood Hits	225	Target Neighborhood Hits	314	Shared Neighborhood Hits	81
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PRG4_MOUSE
θ value	2.36792 (rank : 128)	NC score	0.033686 (rank : 394)
Query Neighborhood Hits	225	Target Neighborhood Hits	624	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SPEG_HUMAN
θ value	2.36792 (rank : 129)	NC score	0.038896 (rank : 382)
Query Neighborhood Hits	225	Target Neighborhood Hits	1762	Shared Neighborhood Hits	96
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TAB3_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.026335 (rank : 410)
Query Neighborhood Hits	225	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

TP53B_MOUSE
θ value	2.36792 (rank : 131)	NC score	0.046185 (rank : 369)
Query Neighborhood Hits	225	Target Neighborhood Hits	644	Shared Neighborhood Hits	51
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

USH1C_MOUSE
θ value	2.36792 (rank : 132)	NC score	0.018191 (rank : 439)
Query Neighborhood Hits	225	Target Neighborhood Hits	557	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

CISH_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.118691 (rank : 60)
Query Neighborhood Hits	225	Target Neighborhood Hits	94	Shared Neighborhood Hits	51
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CN155_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.042280 (rank : 373)
Query Neighborhood Hits	225	Target Neighborhood Hits	385	Shared Neighborhood Hits	29
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

DDEF2_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.036861 (rank : 385)
Query Neighborhood Hits	225	Target Neighborhood Hits	599	Shared Neighborhood Hits	50
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDR1_MOUSE
θ value	3.0926 (rank : 136)	NC score	0.067084 (rank : 167)
Query Neighborhood Hits	225	Target Neighborhood Hits	818	Shared Neighborhood Hits	45
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FYN_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.103591 (rank : 81)
Query Neighborhood Hits	225	Target Neighborhood Hits	1078	Shared Neighborhood Hits	91
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

HCK_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.100771 (rank : 94)
Query Neighborhood Hits	225	Target Neighborhood Hits	1029	Shared Neighborhood Hits	83
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HSF1_MOUSE
θ value	3.0926 (rank : 139)	NC score	0.034119 (rank : 390)
Query Neighborhood Hits	225	Target Neighborhood Hits	267	Shared Neighborhood Hits	36
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IRS2_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.025817 (rank : 412)
Query Neighborhood Hits	225	Target Neighborhood Hits	262	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

IRX1_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.012572 (rank : 453)
Query Neighborhood Hits	225	Target Neighborhood Hits	285	Shared Neighborhood Hits	7
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

LCK_HUMAN
θ value	3.0926 (rank : 142)	NC score	0.098398 (rank : 104)
Query Neighborhood Hits	225	Target Neighborhood Hits	987	Shared Neighborhood Hits	82
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

PI5PA_MOUSE
θ value	3.0926 (rank : 143)	NC score	0.029680 (rank : 400)
Query Neighborhood Hits	225	Target Neighborhood Hits	331	Shared Neighborhood Hits	36
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SRRM2_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.055458 (rank : 293)
Query Neighborhood Hits	225	Target Neighborhood Hits	1296	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ACINU_HUMAN
θ value	4.03905 (rank : 145)	NC score	0.030680 (rank : 398)
Query Neighborhood Hits	225	Target Neighborhood Hits	828	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

AFF1_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.025163 (rank : 416)
Query Neighborhood Hits	225	Target Neighborhood Hits	506	Shared Neighborhood Hits	32
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

BSN_HUMAN
θ value	4.03905 (rank : 147)	NC score	0.047634 (rank : 365)
Query Neighborhood Hits	225	Target Neighborhood Hits	1537	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CBL_MOUSE
θ value	4.03905 (rank : 148)	NC score	0.027016 (rank : 406)
Query Neighborhood Hits	225	Target Neighborhood Hits	426	Shared Neighborhood Hits	34
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CD248_MOUSE
θ value	4.03905 (rank : 149)	NC score	0.028876 (rank : 401)
Query Neighborhood Hits	225	Target Neighborhood Hits	578	Shared Neighborhood Hits	43
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

DAB1_HUMAN
θ value	4.03905 (rank : 150)	NC score	0.040413 (rank : 379)
Query Neighborhood Hits	225	Target Neighborhood Hits	219	Shared Neighborhood Hits	32
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

DOT1L_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.065500 (rank : 174)
Query Neighborhood Hits	225	Target Neighborhood Hits	660	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

DYN1_HUMAN
θ value	4.03905 (rank : 152)	NC score	0.013413 (rank : 449)
Query Neighborhood Hits	225	Target Neighborhood Hits	216	Shared Neighborhood Hits	16
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

HN1L_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.026955 (rank : 407)
Query Neighborhood Hits	225	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

MEF2D_MOUSE
θ value	4.03905 (rank : 154)	NC score	0.015412 (rank : 444)
Query Neighborhood Hits	225	Target Neighborhood Hits	146	Shared Neighborhood Hits	12
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

MILK1_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.033763 (rank : 393)
Query Neighborhood Hits	225	Target Neighborhood Hits	427	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NU214_HUMAN
θ value	4.03905 (rank : 156)	NC score	0.045248 (rank : 371)
Query Neighborhood Hits	225	Target Neighborhood Hits	657	Shared Neighborhood Hits	50
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PRRT3_HUMAN
θ value	4.03905 (rank : 157)	NC score	0.068284 (rank : 162)
Query Neighborhood Hits	225	Target Neighborhood Hits	998	Shared Neighborhood Hits	83
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RIN2_HUMAN
θ value	4.03905 (rank : 158)	NC score	0.078953 (rank : 138)
Query Neighborhood Hits	225	Target Neighborhood Hits	50	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYP3, Q00425, Q5TFT8, Q9BQL3, Q9H071	Gene names	RIN2, RASSF4
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2) (Ras inhibitor JC265) (Ras association domain family 4).

ROBO3_MOUSE
θ value	4.03905 (rank : 159)	NC score	0.009127 (rank : 460)
Query Neighborhood Hits	225	Target Neighborhood Hits	524	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

TRIO_HUMAN
θ value	4.03905 (rank : 160)	NC score	0.033216 (rank : 395)
Query Neighborhood Hits	225	Target Neighborhood Hits	1580	Shared Neighborhood Hits	71
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

AATK_MOUSE
θ value	5.27518 (rank : 161)	NC score	0.068369 (rank : 160)
Query Neighborhood Hits	225	Target Neighborhood Hits	942	Shared Neighborhood Hits	60
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.100583 (rank : 96)
Query Neighborhood Hits	225	Target Neighborhood Hits	1220	Shared Neighborhood Hits	110
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	5.27518 (rank : 163)	NC score	0.100654 (rank : 95)
Query Neighborhood Hits	225	Target Neighborhood Hits	1178	Shared Neighborhood Hits	107
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FA53B_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.018652 (rank : 437)
Query Neighborhood Hits	225	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGR5, Q3UGW1, Q8BI13	Gene names	Fam53b
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

K2002_MOUSE
θ value	5.27518 (rank : 165)	NC score	0.022761 (rank : 426)
Query Neighborhood Hits	225	Target Neighborhood Hits	267	Shared Neighborhood Hits	9
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

LCK_MOUSE
θ value	5.27518 (rank : 166)	NC score	0.097272 (rank : 109)
Query Neighborhood Hits	225	Target Neighborhood Hits	981	Shared Neighborhood Hits	82
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LNK_HUMAN
θ value	5.27518 (rank : 167)	NC score	0.129903 (rank : 50)
Query Neighborhood Hits	225	Target Neighborhood Hits	151	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_MOUSE
θ value	5.27518 (rank : 168)	NC score	0.095895 (rank : 115)
Query Neighborhood Hits	225	Target Neighborhood Hits	952	Shared Neighborhood Hits	89
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MUC15_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.023709 (rank : 420)
Query Neighborhood Hits	225	Target Neighborhood Hits	61	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N387, Q6UWS3, Q8IXI8, Q8WW41	Gene names	MUC15
Domain Architecture	No domain graphic available
Description	Mucin-15 precursor.

MUC2_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.049958 (rank : 359)
Query Neighborhood Hits	225	Target Neighborhood Hits	906	Shared Neighborhood Hits	58
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MUC7_HUMAN
θ value	5.27518 (rank : 171)	NC score	0.075259 (rank : 145)
Query Neighborhood Hits	225	Target Neighborhood Hits	538	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCK1_HUMAN
θ value	5.27518 (rank : 172)	NC score	0.169851 (rank : 25)
Query Neighborhood Hits	225	Target Neighborhood Hits	312	Shared Neighborhood Hits	80
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NFAC3_HUMAN
θ value	5.27518 (rank : 173)	NC score	0.019033 (rank : 436)
Query Neighborhood Hits	225	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

NFAC3_MOUSE
θ value	5.27518 (rank : 174)	NC score	0.017898 (rank : 442)
Query Neighborhood Hits	225	Target Neighborhood Hits	106	Shared Neighborhood Hits	11
SwissProt Accessions	P97305, Q60896	Gene names	Nfatc3, Nfat4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

NMDE3_MOUSE
θ value	5.27518 (rank : 175)	NC score	0.006397 (rank : 465)
Query Neighborhood Hits	225	Target Neighborhood Hits	86	Shared Neighborhood Hits	6
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NOTC3_MOUSE
θ value	5.27518 (rank : 176)	NC score	0.003849 (rank : 467)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	23
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PHC1_HUMAN
θ value	5.27518 (rank : 177)	NC score	0.024759 (rank : 417)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

PHLPL_HUMAN
θ value	5.27518 (rank : 178)	NC score	0.004333 (rank : 466)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PININ_MOUSE
θ value	5.27518 (rank : 179)	NC score	0.030859 (rank : 397)
Query Neighborhood Hits	225	Target Neighborhood Hits	777	Shared Neighborhood Hits	18
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PTN6_MOUSE
θ value	5.27518 (rank : 180)	NC score	0.096487 (rank : 113)
Query Neighborhood Hits	225	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RERE_MOUSE
θ value	5.27518 (rank : 181)	NC score	0.048419 (rank : 363)
Query Neighborhood Hits	225	Target Neighborhood Hits	785	Shared Neighborhood Hits	53
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SHAN1_HUMAN
θ value	5.27518 (rank : 182)	NC score	0.047813 (rank : 364)
Query Neighborhood Hits	225	Target Neighborhood Hits	1041	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

3BP1_HUMAN
θ value	6.88961 (rank : 183)	NC score	0.030043 (rank : 399)
Query Neighborhood Hits	225	Target Neighborhood Hits	376	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AAKG2_MOUSE
θ value	6.88961 (rank : 184)	NC score	0.010263 (rank : 457)
Query Neighborhood Hits	225	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG5, Q6V7V5	Gene names	Prkag2
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma-2 chain) (AMPK gamma2).

ATF2_MOUSE
θ value	6.88961 (rank : 185)	NC score	0.020442 (rank : 432)
Query Neighborhood Hits	225	Target Neighborhood Hits	397	Shared Neighborhood Hits	29
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

GAB2_MOUSE
θ value	6.88961 (rank : 186)	NC score	0.025647 (rank : 413)
Query Neighborhood Hits	225	Target Neighborhood Hits	220	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

K1849_MOUSE
θ value	6.88961 (rank : 187)	NC score	0.012842 (rank : 451)
Query Neighborhood Hits	225	Target Neighborhood Hits	335	Shared Neighborhood Hits	18
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MAST3_HUMAN
θ value	6.88961 (rank : 188)	NC score	0.023946 (rank : 419)
Query Neighborhood Hits	225	Target Neighborhood Hits	1128	Shared Neighborhood Hits	71
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MCR_MOUSE
θ value	6.88961 (rank : 189)	NC score	0.009068 (rank : 461)
Query Neighborhood Hits	225	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PDZD2_HUMAN
θ value	6.88961 (rank : 190)	NC score	0.033795 (rank : 392)
Query Neighborhood Hits	225	Target Neighborhood Hits	772	Shared Neighborhood Hits	60
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PITM1_HUMAN
θ value	6.88961 (rank : 191)	NC score	0.026272 (rank : 411)
Query Neighborhood Hits	225	Target Neighborhood Hits	129	Shared Neighborhood Hits	13
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

PITM1_MOUSE
θ value	6.88961 (rank : 192)	NC score	0.014441 (rank : 446)
Query Neighborhood Hits	225	Target Neighborhood Hits	69	Shared Neighborhood Hits	10
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

R3HD1_HUMAN
θ value	6.88961 (rank : 193)	NC score	0.023656 (rank : 422)
Query Neighborhood Hits	225	Target Neighborhood Hits	203	Shared Neighborhood Hits	17
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

RIMB1_HUMAN
θ value	6.88961 (rank : 194)	NC score	0.040518 (rank : 378)
Query Neighborhood Hits	225	Target Neighborhood Hits	1479	Shared Neighborhood Hits	81
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RSMN_HUMAN
θ value	6.88961 (rank : 195)	NC score	0.023280 (rank : 424)
Query Neighborhood Hits	225	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
θ value	6.88961 (rank : 196)	NC score	0.023280 (rank : 425)
Query Neighborhood Hits	225	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

SH22A_MOUSE
θ value	6.88961 (rank : 197)	NC score	0.129071 (rank : 52)
Query Neighborhood Hits	225	Target Neighborhood Hits	179	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH2D3_HUMAN
θ value	6.88961 (rank : 198)	NC score	0.074845 (rank : 146)
Query Neighborhood Hits	225	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SRRM2_MOUSE
θ value	6.88961 (rank : 199)	NC score	0.072001 (rank : 153)
Query Neighborhood Hits	225	Target Neighborhood Hits	1470	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

VGF_HUMAN
θ value	6.88961 (rank : 200)	NC score	0.031552 (rank : 396)
Query Neighborhood Hits	225	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

ZAN_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.017960 (rank : 441)
Query Neighborhood Hits	225	Target Neighborhood Hits	679	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ATF2_HUMAN
θ value	8.99809 (rank : 202)	NC score	0.019619 (rank : 434)
Query Neighborhood Hits	225	Target Neighborhood Hits	402	Shared Neighborhood Hits	29
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

ATF6B_MOUSE
θ value	8.99809 (rank : 203)	NC score	0.014086 (rank : 447)
Query Neighborhood Hits	225	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

BRD4_MOUSE
θ value	8.99809 (rank : 204)	NC score	0.025509 (rank : 415)
Query Neighborhood Hits	225	Target Neighborhood Hits	845	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CBL_HUMAN
θ value	8.99809 (rank : 205)	NC score	0.021885 (rank : 428)
Query Neighborhood Hits	225	Target Neighborhood Hits	353	Shared Neighborhood Hits	24
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CHKA_HUMAN
θ value	8.99809 (rank : 206)	NC score	0.009784 (rank : 459)
Query Neighborhood Hits	225	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P35790, Q8NE29	Gene names	CHKA, CHK, CKI
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

CIC_MOUSE
θ value	8.99809 (rank : 207)	NC score	0.042158 (rank : 374)
Query Neighborhood Hits	225	Target Neighborhood Hits	742	Shared Neighborhood Hits	60
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DLX2_HUMAN
θ value	8.99809 (rank : 208)	NC score	0.001979 (rank : 469)
Query Neighborhood Hits	225	Target Neighborhood Hits	355	Shared Neighborhood Hits	7
SwissProt Accessions	Q07687	Gene names	DLX2
Domain Architecture
Description	Homeobox protein DLX-2.

EYA2_MOUSE
θ value	8.99809 (rank : 209)	NC score	0.007171 (rank : 464)
Query Neighborhood Hits	225	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	O08575, P97925	Gene names	Eya2, Eab1
Domain Architecture
Description	Eyes absent homolog 2 (EC 3.1.3.48).

FRK_HUMAN
θ value	8.99809 (rank : 210)	NC score	0.094985 (rank : 117)
Query Neighborhood Hits	225	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GP152_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.012863 (rank : 450)
Query Neighborhood Hits	225	Target Neighborhood Hits	636	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

GRAP_HUMAN
θ value	8.99809 (rank : 212)	NC score	0.188544 (rank : 18)
Query Neighborhood Hits	225	Target Neighborhood Hits	307	Shared Neighborhood Hits	82
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	8.99809 (rank : 213)	NC score	0.188636 (rank : 17)
Query Neighborhood Hits	225	Target Neighborhood Hits	309	Shared Neighborhood Hits	83
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

JIP1_HUMAN
θ value	8.99809 (rank : 214)	NC score	0.034097 (rank : 391)
Query Neighborhood Hits	225	Target Neighborhood Hits	271	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LBXCO_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.012582 (rank : 452)
Query Neighborhood Hits	225	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

PAPOG_MOUSE
θ value	8.99809 (rank : 216)	NC score	0.008571 (rank : 462)
Query Neighborhood Hits	225	Target Neighborhood Hits	103	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PCL9, Q8BZC9	Gene names	Papolg
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme).

PCLO_HUMAN
θ value	8.99809 (rank : 217)	NC score	0.046682 (rank : 367)
Query Neighborhood Hits	225	Target Neighborhood Hits	2046	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RAPH1_HUMAN
θ value	8.99809 (rank : 218)	NC score	0.055289 (rank : 299)
Query Neighborhood Hits	225	Target Neighborhood Hits	593	Shared Neighborhood Hits	59
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SHAN2_HUMAN
θ value	8.99809 (rank : 219)	NC score	0.020840 (rank : 430)
Query Neighborhood Hits	225	Target Neighborhood Hits	346	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SPEG_MOUSE
θ value	8.99809 (rank : 220)	NC score	0.037212 (rank : 384)
Query Neighborhood Hits	225	Target Neighborhood Hits	1959	Shared Neighborhood Hits	114
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SSPO_MOUSE
θ value	8.99809 (rank : 221)	NC score	0.012335 (rank : 454)
Query Neighborhood Hits	225	Target Neighborhood Hits	800	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

TARA_HUMAN
θ value	8.99809 (rank : 222)	NC score	0.046183 (rank : 370)
Query Neighborhood Hits	225	Target Neighborhood Hits	1626	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TFG_HUMAN
θ value	8.99809 (rank : 223)	NC score	0.038199 (rank : 383)
Query Neighborhood Hits	225	Target Neighborhood Hits	122	Shared Neighborhood Hits	13
SwissProt Accessions	Q92734, Q15656	Gene names	TFG
Domain Architecture
Description	Protein TFG (TRK-fused gene protein).

ZN318_HUMAN
θ value	8.99809 (rank : 224)	NC score	0.013834 (rank : 448)
Query Neighborhood Hits	225	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ZN366_HUMAN
θ value	8.99809 (rank : 225)	NC score	-0.001368 (rank : 470)
Query Neighborhood Hits	225	Target Neighborhood Hits	732	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N895, Q7RTV4	Gene names	ZNF366
Domain Architecture	No domain graphic available
Description	Zinc finger protein 366.

AATK_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.066424 (rank : 172)
Query Neighborhood Hits	225	Target Neighborhood Hits	1243	Shared Neighborhood Hits	80
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ACK1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.067584 (rank : 166)
Query Neighborhood Hits	225	Target Neighborhood Hits	1140	Shared Neighborhood Hits	77
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.068022 (rank : 164)
Query Neighborhood Hits	225	Target Neighborhood Hits	1080	Shared Neighborhood Hits	77
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ALEX_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.051006 (rank : 350)
Query Neighborhood Hits	225	Target Neighborhood Hits	361	Shared Neighborhood Hits	46
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ALK_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.063099 (rank : 183)
Query Neighborhood Hits	225	Target Neighborhood Hits	795	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.063282 (rank : 182)
Query Neighborhood Hits	225	Target Neighborhood Hits	811	Shared Neighborhood Hits	42
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANPRA_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.052422 (rank : 336)
Query Neighborhood Hits	225	Target Neighborhood Hits	612	Shared Neighborhood Hits	41
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.051858 (rank : 344)
Query Neighborhood Hits	225	Target Neighborhood Hits	600	Shared Neighborhood Hits	41
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.050399 (rank : 355)
Query Neighborhood Hits	225	Target Neighborhood Hits	646	Shared Neighborhood Hits	43
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.050727 (rank : 353)
Query Neighborhood Hits	225	Target Neighborhood Hits	607	Shared Neighborhood Hits	43
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.107959 (rank : 71)
Query Neighborhood Hits	225	Target Neighborhood Hits	162	Shared Neighborhood Hits	68
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.090063 (rank : 121)
Query Neighborhood Hits	225	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

AUXI_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.069771 (rank : 156)
Query Neighborhood Hits	225	Target Neighborhood Hits	99	Shared Neighborhood Hits	6
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

AUXI_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.069420 (rank : 158)
Query Neighborhood Hits	225	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TZ3, Q6P2K9, Q8C7L9	Gene names	Dnajc6, Kiaa0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

BCAR1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.051899 (rank : 343)
Query Neighborhood Hits	225	Target Neighborhood Hits	438	Shared Neighborhood Hits	75
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR3_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.072014 (rank : 152)
Query Neighborhood Hits	225	Target Neighborhood Hits	129	Shared Neighborhood Hits	53
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.068138 (rank : 163)
Query Neighborhood Hits	225	Target Neighborhood Hits	127	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BLNK_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.090016 (rank : 122)
Query Neighborhood Hits	225	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CD2AP_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.055626 (rank : 292)
Query Neighborhood Hits	225	Target Neighborhood Hits	315	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.052792 (rank : 333)
Query Neighborhood Hits	225	Target Neighborhood Hits	336	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHIO_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.051360 (rank : 346)
Query Neighborhood Hits	225	Target Neighborhood Hits	220	Shared Neighborhood Hits	54
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CISH_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.103264 (rank : 83)
Query Neighborhood Hits	225	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CSF1R_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.059095 (rank : 226)
Query Neighborhood Hits	225	Target Neighborhood Hits	943	Shared Neighborhood Hits	42
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.058311 (rank : 241)
Query Neighborhood Hits	225	Target Neighborhood Hits	983	Shared Neighborhood Hits	42
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

DAPP1_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.144111 (rank : 34)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.147162 (rank : 32)
Query Neighborhood Hits	225	Target Neighborhood Hits	225	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDR2_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.059367 (rank : 222)
Query Neighborhood Hits	225	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.060017 (rank : 209)
Query Neighborhood Hits	225	Target Neighborhood Hits	813	Shared Neighborhood Hits	42
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DNMBP_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.059906 (rank : 213)
Query Neighborhood Hits	225	Target Neighborhood Hits	413	Shared Neighborhood Hits	54
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.056436 (rank : 280)
Query Neighborhood Hits	225	Target Neighborhood Hits	435	Shared Neighborhood Hits	65
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.054110 (rank : 316)
Query Neighborhood Hits	225	Target Neighborhood Hits	389	Shared Neighborhood Hits	62
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EGFR_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.058326 (rank : 240)
Query Neighborhood Hits	225	Target Neighborhood Hits	939	Shared Neighborhood Hits	48
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.058290 (rank : 242)
Query Neighborhood Hits	225	Target Neighborhood Hits	927	Shared Neighborhood Hits	45
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.058371 (rank : 238)
Query Neighborhood Hits	225	Target Neighborhood Hits	997	Shared Neighborhood Hits	50
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.058890 (rank : 230)
Query Neighborhood Hits	225	Target Neighborhood Hits	958	Shared Neighborhood Hits	50
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.058102 (rank : 248)
Query Neighborhood Hits	225	Target Neighborhood Hits	1021	Shared Neighborhood Hits	48
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.058025 (rank : 251)
Query Neighborhood Hits	225	Target Neighborhood Hits	1020	Shared Neighborhood Hits	49
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.055311 (rank : 297)
Query Neighborhood Hits	225	Target Neighborhood Hits	1005	Shared Neighborhood Hits	45
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.055390 (rank : 294)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.056055 (rank : 286)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	47
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.056072 (rank : 285)
Query Neighborhood Hits	225	Target Neighborhood Hits	982	Shared Neighborhood Hits	47
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.056651 (rank : 274)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	50
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.058943 (rank : 228)
Query Neighborhood Hits	225	Target Neighborhood Hits	950	Shared Neighborhood Hits	48
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.058800 (rank : 233)
Query Neighborhood Hits	225	Target Neighborhood Hits	959	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.058722 (rank : 234)
Query Neighborhood Hits	225	Target Neighborhood Hits	946	Shared Neighborhood Hits	47
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.055306 (rank : 298)
Query Neighborhood Hits	225	Target Neighborhood Hits	1053	Shared Neighborhood Hits	48
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.055244 (rank : 301)
Query Neighborhood Hits	225	Target Neighborhood Hits	1025	Shared Neighborhood Hits	47
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.057260 (rank : 266)
Query Neighborhood Hits	225	Target Neighborhood Hits	956	Shared Neighborhood Hits	47
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.057519 (rank : 262)
Query Neighborhood Hits	225	Target Neighborhood Hits	969	Shared Neighborhood Hits	48
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.061268 (rank : 191)
Query Neighborhood Hits	225	Target Neighborhood Hits	960	Shared Neighborhood Hits	50
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.056178 (rank : 282)
Query Neighborhood Hits	225	Target Neighborhood Hits	988	Shared Neighborhood Hits	49
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.056588 (rank : 275)
Query Neighborhood Hits	225	Target Neighborhood Hits	983	Shared Neighborhood Hits	47
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.056516 (rank : 277)
Query Neighborhood Hits	225	Target Neighborhood Hits	982	Shared Neighborhood Hits	47
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.057571 (rank : 258)
Query Neighborhood Hits	225	Target Neighborhood Hits	996	Shared Neighborhood Hits	51
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.057529 (rank : 260)
Query Neighborhood Hits	225	Target Neighborhood Hits	996	Shared Neighborhood Hits	49
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.056861 (rank : 271)
Query Neighborhood Hits	225	Target Neighborhood Hits	1056	Shared Neighborhood Hits	50
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.056666 (rank : 273)
Query Neighborhood Hits	225	Target Neighborhood Hits	1013	Shared Neighborhood Hits	50
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.060595 (rank : 197)
Query Neighborhood Hits	225	Target Neighborhood Hits	912	Shared Neighborhood Hits	51
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.059983 (rank : 211)
Query Neighborhood Hits	225	Target Neighborhood Hits	906	Shared Neighborhood Hits	50
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.061634 (rank : 187)
Query Neighborhood Hits	225	Target Neighborhood Hits	1073	Shared Neighborhood Hits	61
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.060004 (rank : 210)
Query Neighborhood Hits	225	Target Neighborhood Hits	918	Shared Neighborhood Hits	46
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.059634 (rank : 218)
Query Neighborhood Hits	225	Target Neighborhood Hits	918	Shared Neighborhood Hits	40
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.060215 (rank : 205)
Query Neighborhood Hits	225	Target Neighborhood Hits	898	Shared Neighborhood Hits	44
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.059770 (rank : 214)
Query Neighborhood Hits	225	Target Neighborhood Hits	910	Shared Neighborhood Hits	42
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.051060 (rank : 349)
Query Neighborhood Hits	225	Target Neighborhood Hits	193	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.052551 (rank : 334)
Query Neighborhood Hits	225	Target Neighborhood Hits	169	Shared Neighborhood Hits	49
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.057814 (rank : 255)
Query Neighborhood Hits	225	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.050666 (rank : 354)
Query Neighborhood Hits	225	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FAK1_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.058113 (rank : 247)
Query Neighborhood Hits	225	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.058027 (rank : 250)
Query Neighborhood Hits	225	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.060685 (rank : 195)
Query Neighborhood Hits	225	Target Neighborhood Hits	847	Shared Neighborhood Hits	41
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.060319 (rank : 204)
Query Neighborhood Hits	225	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.080693 (rank : 133)
Query Neighborhood Hits	225	Target Neighborhood Hits	1278	Shared Neighborhood Hits	93
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.068362 (rank : 161)
Query Neighborhood Hits	225	Target Neighborhood Hits	978	Shared Neighborhood Hits	69
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.066813 (rank : 170)
Query Neighborhood Hits	225	Target Neighborhood Hits	980	Shared Neighborhood Hits	72
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.054511 (rank : 310)
Query Neighborhood Hits	225	Target Neighborhood Hits	1069	Shared Neighborhood Hits	44
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.054565 (rank : 308)
Query Neighborhood Hits	225	Target Neighborhood Hits	1068	Shared Neighborhood Hits	44
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.054555 (rank : 309)
Query Neighborhood Hits	225	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.054596 (rank : 307)
Query Neighborhood Hits	225	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.055326 (rank : 296)
Query Neighborhood Hits	225	Target Neighborhood Hits	1042	Shared Neighborhood Hits	44
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.054992 (rank : 304)
Query Neighborhood Hits	225	Target Neighborhood Hits	1059	Shared Neighborhood Hits	43
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.056577 (rank : 276)
Query Neighborhood Hits	225	Target Neighborhood Hits	1037	Shared Neighborhood Hits	44
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.057527 (rank : 261)
Query Neighborhood Hits	225	Target Neighborhood Hits	1026	Shared Neighborhood Hits	43
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FGR_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.102705 (rank : 86)
Query Neighborhood Hits	225	Target Neighborhood Hits	1067	Shared Neighborhood Hits	91
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLT3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.059214 (rank : 223)
Query Neighborhood Hits	225	Target Neighborhood Hits	843	Shared Neighborhood Hits	42
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.060080 (rank : 207)
Query Neighborhood Hits	225	Target Neighborhood Hits	847	Shared Neighborhood Hits	42
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FYN_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.098035 (rank : 105)
Query Neighborhood Hits	225	Target Neighborhood Hits	1073	Shared Neighborhood Hits	87
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAK_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.055673 (rank : 290)
Query Neighborhood Hits	225	Target Neighborhood Hits	1028	Shared Neighborhood Hits	59
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.054060 (rank : 317)
Query Neighborhood Hits	225	Target Neighborhood Hits	964	Shared Neighborhood Hits	53
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GRB14_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.133404 (rank : 49)
Query Neighborhood Hits	225	Target Neighborhood Hits	137	Shared Neighborhood Hits	68
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.123947 (rank : 54)
Query Neighborhood Hits	225	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.119927 (rank : 59)
Query Neighborhood Hits	225	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GUC2C_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.051233 (rank : 347)
Query Neighborhood Hits	225	Target Neighborhood Hits	624	Shared Neighborhood Hits	38
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2F_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.054044 (rank : 318)
Query Neighborhood Hits	225	Target Neighborhood Hits	740	Shared Neighborhood Hits	41
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.051147 (rank : 348)
Query Neighborhood Hits	225	Target Neighborhood Hits	644	Shared Neighborhood Hits	42
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCLS1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.053883 (rank : 323)
Query Neighborhood Hits	225	Target Neighborhood Hits	358	Shared Neighborhood Hits	62
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

IGF1R_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.060061 (rank : 208)
Query Neighborhood Hits	225	Target Neighborhood Hits	977	Shared Neighborhood Hits	43
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.059944 (rank : 212)
Query Neighborhood Hits	225	Target Neighborhood Hits	973	Shared Neighborhood Hits	42
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ILK1_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.054434 (rank : 313)
Query Neighborhood Hits	225	Target Neighborhood Hits	857	Shared Neighborhood Hits	45
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.053792 (rank : 326)
Query Neighborhood Hits	225	Target Neighborhood Hits	848	Shared Neighborhood Hits	45
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.054798 (rank : 306)
Query Neighborhood Hits	225	Target Neighborhood Hits	858	Shared Neighborhood Hits	45
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.059767 (rank : 215)
Query Neighborhood Hits	225	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.059666 (rank : 216)
Query Neighborhood Hits	225	Target Neighborhood Hits	961	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.058667 (rank : 236)
Query Neighborhood Hits	225	Target Neighborhood Hits	963	Shared Neighborhood Hits	43
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.058251 (rank : 244)
Query Neighborhood Hits	225	Target Neighborhood Hits	968	Shared Neighborhood Hits	43
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

JAK1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.053929 (rank : 322)
Query Neighborhood Hits	225	Target Neighborhood Hits	858	Shared Neighborhood Hits	46
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.054367 (rank : 314)
Query Neighborhood Hits	225	Target Neighborhood Hits	854	Shared Neighborhood Hits	46
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.051704 (rank : 345)
Query Neighborhood Hits	225	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.052042 (rank : 341)
Query Neighborhood Hits	225	Target Neighborhood Hits	839	Shared Neighborhood Hits	44
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.052477 (rank : 335)
Query Neighborhood Hits	225	Target Neighborhood Hits	827	Shared Neighborhood Hits	41
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.050294 (rank : 356)
Query Neighborhood Hits	225	Target Neighborhood Hits	821	Shared Neighborhood Hits	41
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KIT_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.057314 (rank : 265)
Query Neighborhood Hits	225	Target Neighborhood Hits	953	Shared Neighborhood Hits	43
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.058408 (rank : 237)
Query Neighborhood Hits	225	Target Neighborhood Hits	949	Shared Neighborhood Hits	43
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSYK_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.079463 (rank : 136)
Query Neighborhood Hits	225	Target Neighborhood Hits	901	Shared Neighborhood Hits	82
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.080055 (rank : 134)
Query Neighborhood Hits	225	Target Neighborhood Hits	944	Shared Neighborhood Hits	83
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LCP2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.096273 (rank : 114)
Query Neighborhood Hits	225	Target Neighborhood Hits	531	Shared Neighborhood Hits	84
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.070861 (rank : 155)
Query Neighborhood Hits	225	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LTK_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.065188 (rank : 175)
Query Neighborhood Hits	225	Target Neighborhood Hits	774	Shared Neighborhood Hits	43
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.064830 (rank : 177)
Query Neighborhood Hits	225	Target Neighborhood Hits	770	Shared Neighborhood Hits	44
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K10_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.053956 (rank : 321)
Query Neighborhood Hits	225	Target Neighborhood Hits	1071	Shared Neighborhood Hits	66
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.055642 (rank : 291)
Query Neighborhood Hits	225	Target Neighborhood Hits	1136	Shared Neighborhood Hits	78
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.053510 (rank : 327)
Query Neighborhood Hits	225	Target Neighborhood Hits	1123	Shared Neighborhood Hits	74
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.055265 (rank : 300)
Query Neighborhood Hits	225	Target Neighborhood Hits	1087	Shared Neighborhood Hits	67
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MDC1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.052827 (rank : 332)
Query Neighborhood Hits	225	Target Neighborhood Hits	1446	Shared Neighborhood Hits	92
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.066816 (rank : 169)
Query Neighborhood Hits	225	Target Neighborhood Hits	998	Shared Neighborhood Hits	80
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MERTK_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.060514 (rank : 199)
Query Neighborhood Hits	225	Target Neighborhood Hits	988	Shared Neighborhood Hits	43
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.060390 (rank : 203)
Query Neighborhood Hits	225	Target Neighborhood Hits	974	Shared Neighborhood Hits	45
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.057537 (rank : 259)
Query Neighborhood Hits	225	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.057872 (rank : 254)
Query Neighborhood Hits	225	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MUC1_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.052994 (rank : 330)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	82
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MUSK_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.056248 (rank : 281)
Query Neighborhood Hits	225	Target Neighborhood Hits	1074	Shared Neighborhood Hits	42
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.056745 (rank : 272)
Query Neighborhood Hits	225	Target Neighborhood Hits	1057	Shared Neighborhood Hits	42
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NACAM_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.060082 (rank : 206)
Query Neighborhood Hits	225	Target Neighborhood Hits	1866	Shared Neighborhood Hits	111
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCF2_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.052289 (rank : 338)
Query Neighborhood Hits	225	Target Neighborhood Hits	229	Shared Neighborhood Hits	42
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK2_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.166960 (rank : 27)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOA6_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.060576 (rank : 198)
Query Neighborhood Hits	225	Target Neighborhood Hits	1202	Shared Neighborhood Hits	97
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NPHP1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.079307 (rank : 137)
Query Neighborhood Hits	225	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.080051 (rank : 135)
Query Neighborhood Hits	225	Target Neighborhood Hits	267	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NTRK1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.061474 (rank : 189)
Query Neighborhood Hits	225	Target Neighborhood Hits	1023	Shared Neighborhood Hits	43
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.058262 (rank : 243)
Query Neighborhood Hits	225	Target Neighborhood Hits	1081	Shared Neighborhood Hits	43
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.058238 (rank : 245)
Query Neighborhood Hits	225	Target Neighborhood Hits	1088	Shared Neighborhood Hits	43
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.060415 (rank : 202)
Query Neighborhood Hits	225	Target Neighborhood Hits	1115	Shared Neighborhood Hits	44
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OSTF1_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.059495 (rank : 220)
Query Neighborhood Hits	225	Target Neighborhood Hits	466	Shared Neighborhood Hits	48
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.056102 (rank : 283)
Query Neighborhood Hits	225	Target Neighborhood Hits	467	Shared Neighborhood Hits	49
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.050779 (rank : 352)
Query Neighborhood Hits	225	Target Neighborhood Hits	339	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.050148 (rank : 357)
Query Neighborhood Hits	225	Target Neighborhood Hits	382	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PCLO_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.050927 (rank : 351)
Query Neighborhood Hits	225	Target Neighborhood Hits	2275	Shared Neighborhood Hits	105
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PGFRA_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.058165 (rank : 246)
Query Neighborhood Hits	225	Target Neighborhood Hits	980	Shared Neighborhood Hits	42
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.058337 (rank : 239)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	42
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.059423 (rank : 221)
Query Neighborhood Hits	225	Target Neighborhood Hits	962	Shared Neighborhood Hits	43
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.059132 (rank : 225)
Query Neighborhood Hits	225	Target Neighborhood Hits	960	Shared Neighborhood Hits	42
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PLCG2_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.129537 (rank : 51)
Query Neighborhood Hits	225	Target Neighborhood Hits	280	Shared Neighborhood Hits	78
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.058825 (rank : 232)
Query Neighborhood Hits	225	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.056080 (rank : 284)
Query Neighborhood Hits	225	Target Neighborhood Hits	377	Shared Neighborhood Hits	57
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTEN_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.091875 (rank : 120)
Query Neighborhood Hits	225	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.091875 (rank : 119)
Query Neighborhood Hits	225	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTK6_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.088646 (rank : 124)
Query Neighborhood Hits	225	Target Neighborhood Hits	1020	Shared Neighborhood Hits	83
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.089703 (rank : 123)
Query Neighborhood Hits	225	Target Neighborhood Hits	1026	Shared Neighborhood Hits	84
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.055746 (rank : 288)
Query Neighborhood Hits	225	Target Neighborhood Hits	1103	Shared Neighborhood Hits	43
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN6_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.087164 (rank : 126)
Query Neighborhood Hits	225	Target Neighborhood Hits	234	Shared Neighborhood Hits	74
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

RET_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.056971 (rank : 270)
Query Neighborhood Hits	225	Target Neighborhood Hits	873	Shared Neighborhood Hits	41
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.056447 (rank : 279)
Query Neighborhood Hits	225	Target Neighborhood Hits	884	Shared Neighborhood Hits	41
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIN3_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.057098 (rank : 269)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN3_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.054459 (rank : 312)
Query Neighborhood Hits	225	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RON_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.058677 (rank : 235)
Query Neighborhood Hits	225	Target Neighborhood Hits	842	Shared Neighborhood Hits	42
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.059155 (rank : 224)
Query Neighborhood Hits	225	Target Neighborhood Hits	836	Shared Neighborhood Hits	41
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.057418 (rank : 264)
Query Neighborhood Hits	225	Target Neighborhood Hits	1018	Shared Neighborhood Hits	43
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.057467 (rank : 263)
Query Neighborhood Hits	225	Target Neighborhood Hits	1025	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.057581 (rank : 257)
Query Neighborhood Hits	225	Target Neighborhood Hits	1014	Shared Neighborhood Hits	44
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.058846 (rank : 231)
Query Neighborhood Hits	225	Target Neighborhood Hits	1000	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.062236 (rank : 186)
Query Neighborhood Hits	225	Target Neighborhood Hits	907	Shared Neighborhood Hits	43
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RYK_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.063698 (rank : 180)
Query Neighborhood Hits	225	Target Neighborhood Hits	701	Shared Neighborhood Hits	41
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.063367 (rank : 181)
Query Neighborhood Hits	225	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SH21A_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.099546 (rank : 99)
Query Neighborhood Hits	225	Target Neighborhood Hits	89	Shared Neighborhood Hits	48
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.107518 (rank : 72)
Query Neighborhood Hits	225	Target Neighborhood Hits	89	Shared Neighborhood Hits	50
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.123210 (rank : 55)
Query Neighborhood Hits	225	Target Neighborhood Hits	101	Shared Neighborhood Hits	55
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.120965 (rank : 58)
Query Neighborhood Hits	225	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.101979 (rank : 91)
Query Neighborhood Hits	225	Target Neighborhood Hits	144	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH23A_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.066869 (rank : 168)
Query Neighborhood Hits	225	Target Neighborhood Hits	149	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH2D3_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.071870 (rank : 154)
Query Neighborhood Hits	225	Target Neighborhood Hits	174	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHC1_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.095592 (rank : 116)
Query Neighborhood Hits	225	Target Neighborhood Hits	170	Shared Neighborhood Hits	76
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.096644 (rank : 111)
Query Neighborhood Hits	225	Target Neighborhood Hits	180	Shared Neighborhood Hits	76
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.086324 (rank : 128)
Query Neighborhood Hits	225	Target Neighborhood Hits	170	Shared Neighborhood Hits	73
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.088086 (rank : 125)
Query Neighborhood Hits	225	Target Neighborhood Hits	144	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.091887 (rank : 118)
Query Neighborhood Hits	225	Target Neighborhood Hits	155	Shared Neighborhood Hits	69
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.103469 (rank : 82)
Query Neighborhood Hits	225	Target Neighborhood Hits	151	Shared Neighborhood Hits	73
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.117022 (rank : 61)
Query Neighborhood Hits	225	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.125681 (rank : 53)
Query Neighborhood Hits	225	Target Neighborhood Hits	137	Shared Neighborhood Hits	71
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.136474 (rank : 46)
Query Neighborhood Hits	225	Target Neighborhood Hits	164	Shared Neighborhood Hits	75
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.175485 (rank : 22)
Query Neighborhood Hits	225	Target Neighborhood Hits	113	Shared Neighborhood Hits	68
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.169207 (rank : 26)
Query Neighborhood Hits	225	Target Neighborhood Hits	117	Shared Neighborhood Hits	69
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SOCS1_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.104556 (rank : 76)
Query Neighborhood Hits	225	Target Neighborhood Hits	79	Shared Neighborhood Hits	40
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.102302 (rank : 88)
Query Neighborhood Hits	225	Target Neighborhood Hits	82	Shared Neighborhood Hits	42
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS2_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.086457 (rank : 127)
Query Neighborhood Hits	225	Target Neighborhood Hits	104	Shared Neighborhood Hits	48
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.097549 (rank : 108)
Query Neighborhood Hits	225	Target Neighborhood Hits	94	Shared Neighborhood Hits	48
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.072471 (rank : 148)
Query Neighborhood Hits	225	Target Neighborhood Hits	126	Shared Neighborhood Hits	50
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.072188 (rank : 150)
Query Neighborhood Hits	225	Target Neighborhood Hits	146	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.082804 (rank : 132)
Query Neighborhood Hits	225	Target Neighborhood Hits	154	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SON_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.052421 (rank : 337)
Query Neighborhood Hits	225	Target Neighborhood Hits	1568	Shared Neighborhood Hits	100
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPN90_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.061552 (rank : 188)
Query Neighborhood Hits	225	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.056468 (rank : 278)
Query Neighborhood Hits	225	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.063072 (rank : 184)
Query Neighborhood Hits	225	Target Neighborhood Hits	396	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.061144 (rank : 192)
Query Neighborhood Hits	225	Target Neighborhood Hits	409	Shared Neighborhood Hits	68
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC3_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.055845 (rank : 287)
Query Neighborhood Hits	225	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.054805 (rank : 305)
Query Neighborhood Hits	225	Target Neighborhood Hits	232	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.058016 (rank : 252)
Query Neighborhood Hits	225	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.060597 (rank : 196)
Query Neighborhood Hits	225	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.060944 (rank : 193)
Query Neighborhood Hits	225	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.060903 (rank : 194)
Query Neighborhood Hits	225	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.062444 (rank : 185)
Query Neighborhood Hits	225	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.059572 (rank : 219)
Query Neighborhood Hits	225	Target Neighborhood Hits	285	Shared Neighborhood Hits	44
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.065132 (rank : 176)
Query Neighborhood Hits	225	Target Neighborhood Hits	786	Shared Neighborhood Hits	41
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.063939 (rank : 179)
Query Neighborhood Hits	225	Target Neighborhood Hits	779	Shared Neighborhood Hits	41
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TEX14_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.055725 (rank : 289)
Query Neighborhood Hits	225	Target Neighborhood Hits	1103	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.053078 (rank : 329)
Query Neighborhood Hits	225	Target Neighborhood Hits	1333	Shared Neighborhood Hits	53
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIE1_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.054507 (rank : 311)
Query Neighborhood Hits	225	Target Neighborhood Hits	1241	Shared Neighborhood Hits	47
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.054165 (rank : 315)
Query Neighborhood Hits	225	Target Neighborhood Hits	1266	Shared Neighborhood Hits	48
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.053857 (rank : 325)
Query Neighborhood Hits	225	Target Neighborhood Hits	1192	Shared Neighborhood Hits	43
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.053876 (rank : 324)
Query Neighborhood Hits	225	Target Neighborhood Hits	1204	Shared Neighborhood Hits	43
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNK1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.060489 (rank : 200)
Query Neighborhood Hits	225	Target Neighborhood Hits	815	Shared Neighborhood Hits	47
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.058927 (rank : 229)
Query Neighborhood Hits	225	Target Neighborhood Hits	806	Shared Neighborhood Hits	49
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TPTE2_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.078327 (rank : 139)
Query Neighborhood Hits	225	Target Neighborhood Hits	68	Shared Neighborhood Hits	1
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

TPTE_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.083279 (rank : 131)
Query Neighborhood Hits	225	Target Neighborhood Hits	53	Shared Neighborhood Hits	1
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

TYK2_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.052044 (rank : 340)
Query Neighborhood Hits	225	Target Neighborhood Hits	841	Shared Neighborhood Hits	42
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.052243 (rank : 339)
Query Neighborhood Hits	225	Target Neighborhood Hits	850	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.057174 (rank : 268)
Query Neighborhood Hits	225	Target Neighborhood Hits	995	Shared Neighborhood Hits	44
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.057213 (rank : 267)
Query Neighborhood Hits	225	Target Neighborhood Hits	1007	Shared Neighborhood Hits	44
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.058045 (rank : 249)
Query Neighborhood Hits	225	Target Neighborhood Hits	981	Shared Neighborhood Hits	46
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.057937 (rank : 253)
Query Neighborhood Hits	225	Target Neighborhood Hits	988	Shared Neighborhood Hits	46
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VAV3_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.111364 (rank : 66)
Query Neighborhood Hits	225	Target Neighborhood Hits	398	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.110383 (rank : 69)
Query Neighborhood Hits	225	Target Neighborhood Hits	404	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.103682 (rank : 79)
Query Neighborhood Hits	225	Target Neighborhood Hits	452	Shared Neighborhood Hits	70
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.097810 (rank : 107)
Query Neighborhood Hits	225	Target Neighborhood Hits	430	Shared Neighborhood Hits	69
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VGFR1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.052875 (rank : 331)
Query Neighborhood Hits	225	Target Neighborhood Hits	1109	Shared Neighborhood Hits	42
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.053170 (rank : 328)
Query Neighborhood Hits	225	Target Neighborhood Hits	1118	Shared Neighborhood Hits	43
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.054018 (rank : 319)
Query Neighborhood Hits	225	Target Neighborhood Hits	1103	Shared Neighborhood Hits	44
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.053964 (rank : 320)
Query Neighborhood Hits	225	Target Neighborhood Hits	1089	Shared Neighborhood Hits	44
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.055014 (rank : 303)
Query Neighborhood Hits	225	Target Neighborhood Hits	1037	Shared Neighborhood Hits	42
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.055372 (rank : 295)
Query Neighborhood Hits	225	Target Neighborhood Hits	1056	Shared Neighborhood Hits	42
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VINEX_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.059070 (rank : 227)
Query Neighborhood Hits	225	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.061437 (rank : 190)
Query Neighborhood Hits	225	Target Neighborhood Hits	286	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YES_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.099584 (rank : 98)
Query Neighborhood Hits	225	Target Neighborhood Hits	1059	Shared Neighborhood Hits	84
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.099424 (rank : 100)
Query Neighborhood Hits	225	Target Neighborhood Hits	1052	Shared Neighborhood Hits	83
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.075952 (rank : 142)
Query Neighborhood Hits	225	Target Neighborhood Hits	893	Shared Neighborhood Hits	80
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.077112 (rank : 141)
Query Neighborhood Hits	225	Target Neighborhood Hits	905	Shared Neighborhood Hits	81
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

TENS4_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	225	Target Neighborhood Hits	225	Shared Neighborhood Hits	225
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS4_HUMAN
NC score	0.933118 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	225	Target Neighborhood Hits	214	Shared Neighborhood Hits	103
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS1_HUMAN
NC score	0.627888 (rank : 3)	θ value	5.50685e-82 (rank : 3)
Query Neighborhood Hits	225	Target Neighborhood Hits	400	Shared Neighborhood Hits	84
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

SLAP2_MOUSE
NC score	0.248516 (rank : 4)	θ value	0.0330416 (rank : 20)
Query Neighborhood Hits	225	Target Neighborhood Hits	136	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.247988 (rank : 5)	θ value	0.0148317 (rank : 14)
Query Neighborhood Hits	225	Target Neighborhood Hits	139	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRAP2_HUMAN
NC score	0.216159 (rank : 6)	θ value	0.00869519 (rank : 11)
Query Neighborhood Hits	225	Target Neighborhood Hits	304	Shared Neighborhood Hits	81
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

HSH2D_HUMAN
NC score	0.215247 (rank : 7)	θ value	0.163984 (rank : 39)
Query Neighborhood Hits	225	Target Neighborhood Hits	159	Shared Neighborhood Hits	75
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

GRAP2_MOUSE
NC score	0.210775 (rank : 8)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	225	Target Neighborhood Hits	297	Shared Neighborhood Hits	80
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CRK_HUMAN
NC score	0.203013 (rank : 9)	θ value	0.125558 (rank : 36)
Query Neighborhood Hits	225	Target Neighborhood Hits	308	Shared Neighborhood Hits	86
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.200922 (rank : 10)	θ value	0.125558 (rank : 37)
Query Neighborhood Hits	225	Target Neighborhood Hits	314	Shared Neighborhood Hits	86
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

HSH2D_MOUSE
NC score	0.199219 (rank : 11)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	225	Target Neighborhood Hits	124	Shared Neighborhood Hits	62
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

P55G_MOUSE
NC score	0.198003 (rank : 12)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	225	Target Neighborhood Hits	401	Shared Neighborhood Hits	73
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
NC score	0.194479 (rank : 13)	θ value	0.00869519 (rank : 12)
Query Neighborhood Hits	225	Target Neighborhood Hits	543	Shared Neighborhood Hits	84
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_HUMAN
NC score	0.191663 (rank : 14)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	225	Target Neighborhood Hits	451	Shared Neighborhood Hits	75
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRB2_HUMAN
NC score	0.188928 (rank : 15)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	81
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.188900 (rank : 16)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	225	Target Neighborhood Hits	312	Shared Neighborhood Hits	81
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP_MOUSE
NC score	0.188636 (rank : 17)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	225	Target Neighborhood Hits	309	Shared Neighborhood Hits	83
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.188544 (rank : 18)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	225	Target Neighborhood Hits	307	Shared Neighborhood Hits	82
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CRKL_MOUSE
NC score	0.188403 (rank : 19)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	225	Target Neighborhood Hits	307	Shared Neighborhood Hits	82
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.183061 (rank : 20)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	225	Target Neighborhood Hits	313	Shared Neighborhood Hits	81
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

P85B_MOUSE
NC score	0.178080 (rank : 21)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	225	Target Neighborhood Hits	519	Shared Neighborhood Hits	84
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SLAP1_HUMAN
NC score	0.175485 (rank : 22)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	225	Target Neighborhood Hits	113	Shared Neighborhood Hits	68
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

GRB14_MOUSE
NC score	0.172975 (rank : 23)	θ value	0.0431538 (rank : 24)
Query Neighborhood Hits	225	Target Neighborhood Hits	149	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SH24A_MOUSE
NC score	0.170987 (rank : 24)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	225	Target Neighborhood Hits	326	Shared Neighborhood Hits	60
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

NCK1_HUMAN
NC score	0.169851 (rank : 25)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	225	Target Neighborhood Hits	312	Shared Neighborhood Hits	80
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SLAP1_MOUSE
NC score	0.169207 (rank : 26)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	225	Target Neighborhood Hits	117	Shared Neighborhood Hits	69
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

NCK2_HUMAN
NC score	0.166960 (rank : 27)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RIN1_HUMAN
NC score	0.166924 (rank : 28)	θ value	0.00102713 (rank : 6)
Query Neighborhood Hits	225	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	Q13671, O15010, Q00427, Q96CC8	Gene names	RIN1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1) (Ras inhibitor JC99).

P85A_MOUSE
NC score	0.165886 (rank : 29)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	225	Target Neighborhood Hits	435	Shared Neighborhood Hits	76
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHE_MOUSE
NC score	0.160877 (rank : 30)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	225	Target Neighborhood Hits	169	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

P85A_HUMAN
NC score	0.158956 (rank : 31)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	225	Target Neighborhood Hits	479	Shared Neighborhood Hits	75
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DAPP1_MOUSE
NC score	0.147162 (rank : 32)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	225	Target Neighborhood Hits	225	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RASA1_HUMAN
NC score	0.144879 (rank : 33)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	225	Target Neighborhood Hits	258	Shared Neighborhood Hits	78
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DAPP1_HUMAN
NC score	0.144111 (rank : 34)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLCG1_HUMAN
NC score	0.143074 (rank : 35)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	225	Target Neighborhood Hits	293	Shared Neighborhood Hits	81
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SOCS3_MOUSE
NC score	0.143061 (rank : 36)	θ value	0.47712 (rank : 61)
Query Neighborhood Hits	225	Target Neighborhood Hits	72	Shared Neighborhood Hits	45
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SHB_MOUSE
NC score	0.142947 (rank : 37)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	225	Target Neighborhood Hits	137	Shared Neighborhood Hits	72
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PLCG1_MOUSE
NC score	0.142091 (rank : 38)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	225	Target Neighborhood Hits	314	Shared Neighborhood Hits	81
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

LNK_MOUSE
NC score	0.141368 (rank : 39)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	225	Target Neighborhood Hits	132	Shared Neighborhood Hits	62
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHB_HUMAN
NC score	0.141265 (rank : 40)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	225	Target Neighborhood Hits	141	Shared Neighborhood Hits	74
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SH24A_HUMAN
NC score	0.141040 (rank : 41)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	225	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SOCS3_HUMAN
NC score	0.140686 (rank : 42)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	225	Target Neighborhood Hits	77	Shared Neighborhood Hits	45
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

GRB10_MOUSE
NC score	0.140028 (rank : 43)	θ value	0.47712 (rank : 55)
Query Neighborhood Hits	225	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.139031 (rank : 44)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	225	Target Neighborhood Hits	147	Shared Neighborhood Hits	72
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

VAV2_HUMAN
NC score	0.137526 (rank : 45)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	225	Target Neighborhood Hits	453	Shared Neighborhood Hits	81
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SHE_HUMAN
NC score	0.136474 (rank : 46)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	225	Target Neighborhood Hits	164	Shared Neighborhood Hits	75
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

VAV2_MOUSE
NC score	0.135328 (rank : 47)	θ value	0.0961366 (rank : 35)
Query Neighborhood Hits	225	Target Neighborhood Hits	456	Shared Neighborhood Hits	81
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

RIN1_MOUSE
NC score	0.134012 (rank : 48)	θ value	0.0252991 (rank : 19)
Query Neighborhood Hits	225	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

GRB14_HUMAN
NC score	0.133404 (rank : 49)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	225	Target Neighborhood Hits	137	Shared Neighborhood Hits	68
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

LNK_HUMAN
NC score	0.129903 (rank : 50)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	225	Target Neighborhood Hits	151	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

PLCG2_HUMAN
NC score	0.129537 (rank : 51)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	225	Target Neighborhood Hits	280	Shared Neighborhood Hits	78
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SH22A_MOUSE
NC score	0.129071 (rank : 52)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	225	Target Neighborhood Hits	179	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SHD_MOUSE
NC score	0.125681 (rank : 53)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	225	Target Neighborhood Hits	137	Shared Neighborhood Hits	71
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

GRB7_HUMAN
NC score	0.123947 (rank : 54)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	225	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SH21B_HUMAN
NC score	0.123210 (rank : 55)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	225	Target Neighborhood Hits	101	Shared Neighborhood Hits	55
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PTN11_MOUSE
NC score	0.121529 (rank : 56)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.121515 (rank : 57)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	80
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

SH21B_MOUSE
NC score	0.120965 (rank : 58)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	225	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

GRB7_MOUSE
NC score	0.119927 (rank : 59)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	225	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

CISH_MOUSE
NC score	0.118691 (rank : 60)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	225	Target Neighborhood Hits	94	Shared Neighborhood Hits	51
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SHD_HUMAN
NC score	0.117022 (rank : 61)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	225	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

CSK_MOUSE
NC score	0.115774 (rank : 62)	θ value	0.000270298 (rank : 4)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	89
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.114752 (rank : 63)	θ value	0.000602161 (rank : 5)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	89
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TXK_MOUSE
NC score	0.113437 (rank : 64)	θ value	0.00102713 (rank : 7)
Query Neighborhood Hits	225	Target Neighborhood Hits	980	Shared Neighborhood Hits	84
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BTK_HUMAN
NC score	0.112781 (rank : 65)	θ value	0.00509761 (rank : 9)
Query Neighborhood Hits	225	Target Neighborhood Hits	1026	Shared Neighborhood Hits	80
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

VAV3_HUMAN
NC score	0.111364 (rank : 66)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	225	Target Neighborhood Hits	398	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BTK_MOUSE
NC score	0.111080 (rank : 67)	θ value	0.0193708 (rank : 15)
Query Neighborhood Hits	225	Target Neighborhood Hits	1017	Shared Neighborhood Hits	80
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

TXK_HUMAN
NC score	0.110818 (rank : 68)	θ value	0.00228821 (rank : 8)
Query Neighborhood Hits	225	Target Neighborhood Hits	971	Shared Neighborhood Hits	84
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

VAV3_MOUSE
NC score	0.110383 (rank : 69)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	225	Target Neighborhood Hits	404	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FGR_MOUSE
NC score	0.110240 (rank : 70)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	225	Target Neighborhood Hits	1069	Shared Neighborhood Hits	93
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

APS_HUMAN
NC score	0.107959 (rank : 71)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	225	Target Neighborhood Hits	162	Shared Neighborhood Hits	68
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH21A_MOUSE
NC score	0.107518 (rank : 72)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	225	Target Neighborhood Hits	89	Shared Neighborhood Hits	50
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

BLK_MOUSE
NC score	0.107452 (rank : 73)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	225	Target Neighborhood Hits	992	Shared Neighborhood Hits	88
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

TEC_HUMAN
NC score	0.105403 (rank : 74)	θ value	0.0330416 (rank : 21)
Query Neighborhood Hits	225	Target Neighborhood Hits	1006	Shared Neighborhood Hits	78
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
NC score	0.104635 (rank : 75)	θ value	0.00509761 (rank : 10)
Query Neighborhood Hits	225	Target Neighborhood Hits	1006	Shared Neighborhood Hits	75
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SOCS1_HUMAN
NC score	0.104556 (rank : 76)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	225	Target Neighborhood Hits	79	Shared Neighborhood Hits	40
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SRMS_HUMAN
NC score	0.104507 (rank : 77)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	225	Target Neighborhood Hits	946	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ABL2_HUMAN
NC score	0.104286 (rank : 78)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	225	Target Neighborhood Hits	1045	Shared Neighborhood Hits	97
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

VAV_HUMAN
NC score	0.103682 (rank : 79)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	225	Target Neighborhood Hits	452	Shared Neighborhood Hits	70
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

LYN_MOUSE
NC score	0.103601 (rank : 80)	θ value	0.21417 (rank : 45)
Query Neighborhood Hits	225	Target Neighborhood Hits	1023	Shared Neighborhood Hits	87
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FYN_HUMAN
NC score	0.103591 (rank : 81)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	225	Target Neighborhood Hits	1078	Shared Neighborhood Hits	91
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SHC3_MOUSE
NC score	0.103469 (rank : 82)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	225	Target Neighborhood Hits	151	Shared Neighborhood Hits	73
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

CISH_HUMAN
NC score	0.103264 (rank : 83)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	225	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

BLNK_MOUSE
NC score	0.103077 (rank : 84)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	225	Target Neighborhood Hits	296	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

RIN2_MOUSE
NC score	0.102910 (rank : 85)	θ value	0.47712 (rank : 59)
Query Neighborhood Hits	225	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

FGR_HUMAN
NC score	0.102705 (rank : 86)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	225	Target Neighborhood Hits	1067	Shared Neighborhood Hits	91
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_MOUSE
NC score	0.102461 (rank : 87)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	225	Target Neighborhood Hits	1033	Shared Neighborhood Hits	90
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SOCS1_MOUSE
NC score	0.102302 (rank : 88)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	225	Target Neighborhood Hits	82	Shared Neighborhood Hits	42
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

HCK_HUMAN
NC score	0.102140 (rank : 89)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	225	Target Neighborhood Hits	1035	Shared Neighborhood Hits	90
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

LYN_HUMAN
NC score	0.102113 (rank : 90)	θ value	0.47712 (rank : 56)
Query Neighborhood Hits	225	Target Neighborhood Hits	1022	Shared Neighborhood Hits	86
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SH22A_HUMAN
NC score	0.101979 (rank : 91)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	225	Target Neighborhood Hits	144	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

BLK_HUMAN
NC score	0.101918 (rank : 92)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	225	Target Neighborhood Hits	994	Shared Neighborhood Hits	82
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SRC_HUMAN
NC score	0.101331 (rank : 93)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	225	Target Neighborhood Hits	1058	Shared Neighborhood Hits	90
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

HCK_MOUSE
NC score	0.100771 (rank : 94)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	225	Target Neighborhood Hits	1029	Shared Neighborhood Hits	83
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ABL1_MOUSE
NC score	0.100654 (rank : 95)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	225	Target Neighborhood Hits	1178	Shared Neighborhood Hits	107
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_HUMAN
NC score	0.100583 (rank : 96)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	225	Target Neighborhood Hits	1220	Shared Neighborhood Hits	110
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SRMS_MOUSE
NC score	0.100239 (rank : 97)	θ value	0.62314 (rank : 72)
Query Neighborhood Hits	225	Target Neighborhood Hits	964	Shared Neighborhood Hits	87
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

YES_HUMAN
NC score	0.099584 (rank : 98)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	225	Target Neighborhood Hits	1059	Shared Neighborhood Hits	84
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SH21A_HUMAN
NC score	0.099546 (rank : 99)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	225	Target Neighborhood Hits	89	Shared Neighborhood Hits	48
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

YES_MOUSE
NC score	0.099424 (rank : 100)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	225	Target Neighborhood Hits	1052	Shared Neighborhood Hits	83
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ITK_HUMAN
NC score	0.099153 (rank : 101)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	225	Target Neighborhood Hits	1016	Shared Neighborhood Hits	86
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
NC score	0.099115 (rank : 102)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	225	Target Neighborhood Hits	985	Shared Neighborhood Hits	85
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

CS016_HUMAN
NC score	0.098533 (rank : 103)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	37
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

LCK_HUMAN
NC score	0.098398 (rank : 104)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	225	Target Neighborhood Hits	987	Shared Neighborhood Hits	82
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

FYN_MOUSE
NC score	0.098035 (rank : 105)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	225	Target Neighborhood Hits	1073	Shared Neighborhood Hits	87
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MATK_HUMAN
NC score	0.097895 (rank : 106)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	225	Target Neighborhood Hits	954	Shared Neighborhood Hits	87
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

VAV_MOUSE
NC score	0.097810 (rank : 107)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	225	Target Neighborhood Hits	430	Shared Neighborhood Hits	69
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SOCS2_MOUSE
NC score	0.097549 (rank : 108)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	225	Target Neighborhood Hits	94	Shared Neighborhood Hits	48
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

LCK_MOUSE
NC score	0.097272 (rank : 109)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	225	Target Neighborhood Hits	981	Shared Neighborhood Hits	82
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BMX_HUMAN
NC score	0.097146 (rank : 110)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	225	Target Neighborhood Hits	942	Shared Neighborhood Hits	84
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SHC1_MOUSE
NC score	0.096644 (rank : 111)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	225	Target Neighborhood Hits	180	Shared Neighborhood Hits	76
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

BMX_MOUSE
NC score	0.096488 (rank : 112)	θ value	1.81305 (rank : 99)
Query Neighborhood Hits	225	Target Neighborhood Hits	912	Shared Neighborhood Hits	84
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

PTN6_MOUSE
NC score	0.096487 (rank : 113)	θ value	5.27518 (rank : 180)
Query Neighborhood Hits	225	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

LCP2_HUMAN
NC score	0.096273 (rank : 114)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	225	Target Neighborhood Hits	531	Shared Neighborhood Hits	84
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MATK_MOUSE
NC score	0.095895 (rank : 115)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	225	Target Neighborhood Hits	952	Shared Neighborhood Hits	89
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SHC1_HUMAN
NC score	0.095592 (rank : 116)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	225	Target Neighborhood Hits	170	Shared Neighborhood Hits	76
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

FRK_HUMAN
NC score	0.094985 (rank : 117)	θ value	8.99809 (rank : 210)
Query Neighborhood Hits	225	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SHC3_HUMAN
NC score	0.091887 (rank : 118)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	225	Target Neighborhood Hits	155	Shared Neighborhood Hits	69
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

PTEN_MOUSE
NC score	0.091875 (rank : 119)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	225	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTEN_HUMAN
NC score	0.091875 (rank : 120)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	225	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

APS_MOUSE
NC score	0.090063 (rank : 121)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	225	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BLNK_HUMAN
NC score	0.090016 (rank : 122)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	225	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

PTK6_MOUSE
NC score	0.089703 (rank : 123)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	225	Target Neighborhood Hits	1026	Shared Neighborhood Hits	84
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK6_HUMAN
NC score	0.088646 (rank : 124)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	225	Target Neighborhood Hits	1020	Shared Neighborhood Hits	83
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SHC2_MOUSE
NC score	0.088086 (rank : 125)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	225	Target Neighborhood Hits	144	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

PTN6_HUMAN
NC score	0.087164 (rank : 126)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	225	Target Neighborhood Hits	234	Shared Neighborhood Hits	74
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SOCS2_HUMAN
NC score	0.086457 (rank : 127)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	225	Target Neighborhood Hits	104	Shared Neighborhood Hits	48
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SHC2_HUMAN
NC score	0.086324 (rank : 128)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	225	Target Neighborhood Hits	170	Shared Neighborhood Hits	73
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

BSN_MOUSE
NC score	0.085345 (rank : 129)	θ value	1.81305 (rank : 100)
Query Neighborhood Hits	225	Target Neighborhood Hits	2057	Shared Neighborhood Hits	113
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

MNT_MOUSE
NC score	0.083934 (rank : 130)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	225	Target Neighborhood Hits	432	Shared Neighborhood Hits	36
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

TPTE_HUMAN
NC score	0.083279 (rank : 131)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	225	Target Neighborhood Hits	53	Shared Neighborhood Hits	1
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

SOCS7_MOUSE
NC score	0.082804 (rank : 132)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	225	Target Neighborhood Hits	154	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

FER_HUMAN
NC score	0.080693 (rank : 133)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	225	Target Neighborhood Hits	1278	Shared Neighborhood Hits	93
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

KSYK_MOUSE
NC score	0.080055 (rank : 134)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	225	Target Neighborhood Hits	944	Shared Neighborhood Hits	83
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NPHP1_MOUSE
NC score	0.080051 (rank : 135)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	225	Target Neighborhood Hits	267	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

KSYK_HUMAN
NC score	0.079463 (rank : 136)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	225	Target Neighborhood Hits	901	Shared Neighborhood Hits	82
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NPHP1_HUMAN
NC score	0.079307 (rank : 137)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	225	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RIN2_HUMAN
NC score	0.078953 (rank : 138)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	225	Target Neighborhood Hits	50	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYP3, Q00425, Q5TFT8, Q9BQL3, Q9H071	Gene names	RIN2, RASSF4
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2) (Ras inhibitor JC265) (Ras association domain family 4).

TPTE2_HUMAN
NC score	0.078327 (rank : 139)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	225	Target Neighborhood Hits	68	Shared Neighborhood Hits	1
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

CBP_MOUSE
NC score	0.077118 (rank : 140)	θ value	1.81305 (rank : 101)
Query Neighborhood Hits	225	Target Neighborhood Hits	1051	Shared Neighborhood Hits	87
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

ZAP70_MOUSE
NC score	0.077112 (rank : 141)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	225	Target Neighborhood Hits	905	Shared Neighborhood Hits	81
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_HUMAN
NC score	0.075952 (rank : 142)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	225	Target Neighborhood Hits	893	Shared Neighborhood Hits	80
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

GSCR1_HUMAN
NC score	0.075492 (rank : 143)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	225	Target Neighborhood Hits	674	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

K0310_HUMAN
NC score	0.075401 (rank : 144)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	225	Target Neighborhood Hits	420	Shared Neighborhood Hits	57
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MUC7_HUMAN
NC score	0.075259 (rank : 145)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	225	Target Neighborhood Hits	538	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SH2D3_HUMAN
NC score	0.074845 (rank : 146)	θ value	6.88961 (rank : 198)
Query Neighborhood Hits	225	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

MNT_HUMAN
NC score	0.073686 (rank : 147)	θ value	0.21417 (rank : 46)
Query Neighborhood Hits	225	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

SOCS6_HUMAN
NC score	0.072471 (rank : 148)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	225	Target Neighborhood Hits	126	Shared Neighborhood Hits	50
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SC24C_HUMAN
NC score	0.072195 (rank : 149)	θ value	0.62314 (rank : 69)
Query Neighborhood Hits	225	Target Neighborhood Hits	662	Shared Neighborhood Hits	62
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SOCS6_MOUSE
NC score	0.072188 (rank : 150)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	225	Target Neighborhood Hits	146	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

CBP_HUMAN
NC score	0.072022 (rank : 151)	θ value	0.21417 (rank : 40)
Query Neighborhood Hits	225	Target Neighborhood Hits	941	Shared Neighborhood Hits	70
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

BCAR3_HUMAN
NC score	0.072014 (rank : 152)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	225	Target Neighborhood Hits	129	Shared Neighborhood Hits	53
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

SRRM2_MOUSE
NC score	0.072001 (rank : 153)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	225	Target Neighborhood Hits	1470	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SH2D3_MOUSE
NC score	0.071870 (rank : 154)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	225	Target Neighborhood Hits	174	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

LCP2_MOUSE
NC score	0.070861 (rank : 155)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	225	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

AUXI_HUMAN
NC score	0.069771 (rank : 156)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	225	Target Neighborhood Hits	99	Shared Neighborhood Hits	6
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

RGS3_MOUSE
NC score	0.069580 (rank : 157)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	225	Target Neighborhood Hits	1621	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

AUXI_MOUSE
NC score	0.069420 (rank : 158)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	225	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TZ3, Q6P2K9, Q8C7L9	Gene names	Dnajc6, Kiaa0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

BCAR1_HUMAN
NC score	0.068768 (rank : 159)	θ value	0.163984 (rank : 38)
Query Neighborhood Hits	225	Target Neighborhood Hits	554	Shared Neighborhood Hits	77
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

AATK_MOUSE
NC score	0.068369 (rank : 160)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	225	Target Neighborhood Hits	942	Shared Neighborhood Hits	60
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

FES_HUMAN
NC score	0.068362 (rank : 161)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	225	Target Neighborhood Hits	978	Shared Neighborhood Hits	69
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

PRRT3_HUMAN
NC score	0.068284 (rank : 162)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	225	Target Neighborhood Hits	998	Shared Neighborhood Hits	83
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

BCAR3_MOUSE
NC score	0.068138 (rank : 163)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	225	Target Neighborhood Hits	127	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ACK1_MOUSE
NC score	0.068022 (rank : 164)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	225	Target Neighborhood Hits	1080	Shared Neighborhood Hits	77
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

DDR1_HUMAN
NC score	0.067913 (rank : 165)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	225	Target Neighborhood Hits	819	Shared Neighborhood Hits	45
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

ACK1_HUMAN
NC score	0.067584 (rank : 166)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	225	Target Neighborhood Hits	1140	Shared Neighborhood Hits	77
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

DDR1_MOUSE
NC score	0.067084 (rank : 167)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	225	Target Neighborhood Hits	818	Shared Neighborhood Hits	45
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

SH23A_HUMAN
NC score	0.066869 (rank : 168)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	225	Target Neighborhood Hits	149	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

MDC1_MOUSE
NC score	0.066816 (rank : 169)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	225	Target Neighborhood Hits	998	Shared Neighborhood Hits	80
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

FES_MOUSE
NC score	0.066813 (rank : 170)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	225	Target Neighborhood Hits	980	Shared Neighborhood Hits	72
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MAGE1_HUMAN
NC score	0.066693 (rank : 171)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	225	Target Neighborhood Hits	1389	Shared Neighborhood Hits	96
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

AATK_HUMAN
NC score	0.066424 (rank : 172)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	225	Target Neighborhood Hits	1243	Shared Neighborhood Hits	80
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

WASF1_HUMAN
NC score	0.066415 (rank : 173)	θ value	0.0736092 (rank : 30)
Query Neighborhood Hits	225	Target Neighborhood Hits	260	Shared Neighborhood Hits	29
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

DOT1L_HUMAN
NC score	0.065500 (rank : 174)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	225	Target Neighborhood Hits	660	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

LTK_HUMAN
NC score	0.065188 (rank : 175)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	225	Target Neighborhood Hits	774	Shared Neighborhood Hits	43
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

STYK1_HUMAN
NC score	0.065132 (rank : 176)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	225	Target Neighborhood Hits	786	Shared Neighborhood Hits	41
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

LTK_MOUSE
NC score	0.064830 (rank : 177)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	225	Target Neighborhood Hits	770	Shared Neighborhood Hits	44
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

SAPS1_HUMAN
NC score	0.064374 (rank : 178)	θ value	0.0961366 (rank : 34)
Query Neighborhood Hits	225	Target Neighborhood Hits	704	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

STYK1_MOUSE
NC score	0.063939 (rank : 179)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	225	Target Neighborhood Hits	779	Shared Neighborhood Hits	41
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

RYK_HUMAN
NC score	0.063698 (rank : 180)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	225	Target Neighborhood Hits	701	Shared Neighborhood Hits	41
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
NC score	0.063367 (rank : 181)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	225	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ALK_MOUSE
NC score	0.063282 (rank : 182)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	225	Target Neighborhood Hits	811	Shared Neighborhood Hits	42
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
NC score	0.063099 (rank : 183)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	225	Target Neighborhood Hits	795	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

SRBS1_HUMAN
NC score	0.063072 (rank : 184)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	225	Target Neighborhood Hits	396	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM2_HUMAN
NC score	0.062444 (rank : 185)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	225	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ROS_HUMAN
NC score	0.062236 (rank : 186)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	225	Target Neighborhood Hits	907	Shared Neighborhood Hits	43
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

ERBB2_HUMAN
NC score	0.061634 (rank : 187)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	225	Target Neighborhood Hits	1073	Shared Neighborhood Hits	61
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

SPN90_HUMAN
NC score	0.061552 (rank : 188)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	225	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

NTRK1_HUMAN
NC score	0.061474 (rank : 189)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	225	Target Neighborhood Hits	1023	Shared Neighborhood Hits	43
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

VINEX_MOUSE
NC score	0.061437 (rank : 190)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	225	Target Neighborhood Hits	286	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

EPHAA_HUMAN
NC score	0.061268 (rank : 191)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	225	Target Neighborhood Hits	960	Shared Neighborhood Hits	50
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

SRBS1_MOUSE
NC score	0.061144 (rank : 192)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	225	Target Neighborhood Hits	409	Shared Neighborhood Hits	68
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM1_HUMAN
NC score	0.060944 (rank : 193)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	225	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.060903 (rank : 194)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	225	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

FAK2_HUMAN
NC score	0.060685 (rank : 195)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	225	Target Neighborhood Hits	847	Shared Neighborhood Hits	41
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

STAC_MOUSE
NC score	0.060597 (rank : 196)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	225	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

EPHB6_HUMAN
NC score	0.060595 (rank : 197)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	225	Target Neighborhood Hits	912	Shared Neighborhood Hits	51
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

NCOA6_HUMAN
NC score	0.060576 (rank : 198)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	225	Target Neighborhood Hits	1202	Shared Neighborhood Hits	97
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MERTK_HUMAN
NC score	0.060514 (rank : 199)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	225	Target Neighborhood Hits	988	Shared Neighborhood Hits	43
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

TNK1_HUMAN
NC score	0.060489 (rank : 200)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	225	Target Neighborhood Hits	815	Shared Neighborhood Hits	47
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

WASF1_MOUSE
NC score	0.060470 (rank : 201)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	225	Target Neighborhood Hits	261	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

NTRK3_HUMAN
NC score	0.060415 (rank : 202)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	225	Target Neighborhood Hits	1115	Shared Neighborhood Hits	44
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

MERTK_MOUSE
NC score	0.060390 (rank : 203)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	225	Target Neighborhood Hits	974	Shared Neighborhood Hits	45
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FAK2_MOUSE
NC score	0.060319 (rank : 204)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	225	Target Neighborhood Hits	851	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ERBB3_MOUSE
NC score	0.060215 (rank : 205)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	225	Target Neighborhood Hits	898	Shared Neighborhood Hits	44
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

NACAM_MOUSE
NC score	0.060082 (rank : 206)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	225	Target Neighborhood Hits	1866	Shared Neighborhood Hits	111
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

FLT3_MOUSE
NC score	0.060080 (rank : 207)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	225	Target Neighborhood Hits	847	Shared Neighborhood Hits	42
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

IGF1R_HUMAN
NC score	0.060061 (rank : 208)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	225	Target Neighborhood Hits	977	Shared Neighborhood Hits	43
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

DDR2_MOUSE
NC score	0.060017 (rank : 209)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	225	Target Neighborhood Hits	813	Shared Neighborhood Hits	42
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ERBB2_MOUSE
NC score	0.060004 (rank : 210)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	225	Target Neighborhood Hits	918	Shared Neighborhood Hits	46
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

EPHB6_MOUSE
NC score	0.059983 (rank : 211)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	225	Target Neighborhood Hits	906	Shared Neighborhood Hits	50
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

IGF1R_MOUSE
NC score	0.059944 (rank : 212)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	225	Target Neighborhood Hits	973	Shared Neighborhood Hits	42
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

DNMBP_HUMAN
NC score	0.059906 (rank : 213)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	225	Target Neighborhood Hits	413	Shared Neighborhood Hits	54
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ERBB4_HUMAN
NC score	0.059770 (rank : 214)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	225	Target Neighborhood Hits	910	Shared Neighborhood Hits	42
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

INSRR_HUMAN
NC score	0.059767 (rank : 215)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	225	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
NC score	0.059666 (rank : 216)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	225	Target Neighborhood Hits	961	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

TRI66_HUMAN
NC score	0.059653 (rank : 217)	θ value	0.0113563 (rank : 13)
Query Neighborhood Hits	225	Target Neighborhood Hits	479	Shared Neighborhood Hits	33
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ERBB3_HUMAN
NC score	0.059634 (rank : 218)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	225	Target Neighborhood Hits	918	Shared Neighborhood Hits	40
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

STAM2_MOUSE
NC score	0.059572 (rank : 219)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	225	Target Neighborhood Hits	285	Shared Neighborhood Hits	44
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

OSTF1_HUMAN
NC score	0.059495 (rank : 220)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	225	Target Neighborhood Hits	466	Shared Neighborhood Hits	48
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PGFRB_HUMAN
NC score	0.059423 (rank : 221)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	225	Target Neighborhood Hits	962	Shared Neighborhood Hits	43
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

DDR2_HUMAN
NC score	0.059367 (rank : 222)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	225	Target Neighborhood Hits	818	Shared Neighborhood Hits	41
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FLT3_HUMAN
NC score	0.059214 (rank : 223)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	225	Target Neighborhood Hits	843	Shared Neighborhood Hits	42
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

RON_MOUSE
NC score	0.059155 (rank : 224)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	225	Target Neighborhood Hits	836	Shared Neighborhood Hits	41
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

PGFRB_MOUSE
NC score	0.059132 (rank : 225)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	225	Target Neighborhood Hits	960	Shared Neighborhood Hits	42
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

CSF1R_HUMAN
NC score	0.059095 (rank : 226)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	225	Target Neighborhood Hits	943	Shared Neighborhood Hits	42
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

VINEX_HUMAN
NC score	0.059070 (rank : 227)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	225	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

EPHA5_MOUSE
NC score	0.058943 (rank : 228)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	225	Target Neighborhood Hits	950	Shared Neighborhood Hits	48
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

TNK1_MOUSE
NC score	0.058927 (rank : 229)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	225	Target Neighborhood Hits	806	Shared Neighborhood Hits	49
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

EPHA1_MOUSE
NC score	0.058890 (rank : 230)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	225	Target Neighborhood Hits	958	Shared Neighborhood Hits	50
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

ROR2_MOUSE
NC score	0.058846 (rank : 231)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	225	Target Neighborhood Hits	1000	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

PPIP1_HUMAN
NC score	0.058825 (rank : 232)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	225	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

EPHA6_HUMAN
NC score	0.058800 (rank : 233)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	225	Target Neighborhood Hits	959	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
NC score	0.058722 (rank : 234)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	225	Target Neighborhood Hits	946	Shared Neighborhood Hits	47
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

RON_HUMAN
NC score	0.058677 (rank : 235)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	225	Target Neighborhood Hits	842	Shared Neighborhood Hits	42
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

INSR_HUMAN
NC score	0.058667 (rank : 236)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	225	Target Neighborhood Hits	963	Shared Neighborhood Hits	43
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KIT_MOUSE
NC score	0.058408 (rank : 237)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	225	Target Neighborhood Hits	949	Shared Neighborhood Hits	43
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

EPHA1_HUMAN
NC score	0.058371 (rank : 238)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	225	Target Neighborhood Hits	997	Shared Neighborhood Hits	50
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

PGFRA_MOUSE
NC score	0.058337 (rank : 239)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	42
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

EGFR_HUMAN
NC score	0.058326 (rank : 240)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	225	Target Neighborhood Hits	939	Shared Neighborhood Hits	48
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

CSF1R_MOUSE
NC score	0.058311 (rank : 241)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	225	Target Neighborhood Hits	983	Shared Neighborhood Hits	42
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EGFR_MOUSE
NC score	0.058290 (rank : 242)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	225	Target Neighborhood Hits	927	Shared Neighborhood Hits	45
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

NTRK2_HUMAN
NC score	0.058262 (rank : 243)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	225	Target Neighborhood Hits	1081	Shared Neighborhood Hits	43
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

INSR_MOUSE
NC score	0.058251 (rank : 244)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	225	Target Neighborhood Hits	968	Shared Neighborhood Hits	43
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

NTRK2_MOUSE
NC score	0.058238 (rank : 245)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	225	Target Neighborhood Hits	1088	Shared Neighborhood Hits	43
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

PGFRA_HUMAN
NC score	0.058165 (rank : 246)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	225	Target Neighborhood Hits	980	Shared Neighborhood Hits	42
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

FAK1_HUMAN
NC score	0.058113 (rank : 247)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	225	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

EPHA2_HUMAN
NC score	0.058102 (rank : 248)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	225	Target Neighborhood Hits	1021	Shared Neighborhood Hits	48
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

UFO_HUMAN
NC score	0.058045 (rank : 249)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	225	Target Neighborhood Hits	981	Shared Neighborhood Hits	46
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

FAK1_MOUSE
NC score	0.058027 (rank : 250)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	225	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

EPHA2_MOUSE
NC score	0.058025 (rank : 251)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	225	Target Neighborhood Hits	1020	Shared Neighborhood Hits	49
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

STAC_HUMAN
NC score	0.058016 (rank : 252)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	225	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

UFO_MOUSE
NC score	0.057937 (rank : 253)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	225	Target Neighborhood Hits	988	Shared Neighborhood Hits	46
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

MET_MOUSE
NC score	0.057872 (rank : 254)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	225	Target Neighborhood Hits	844	Shared Neighborhood Hits	41
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ES8L3_HUMAN
NC score	0.057814 (rank : 255)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	225	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PRG4_HUMAN
NC score	0.057710 (rank : 256)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	225	Target Neighborhood Hits	764	Shared Neighborhood Hits	48
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ROR2_HUMAN
NC score	0.057581 (rank : 257)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	225	Target Neighborhood Hits	1014	Shared Neighborhood Hits	44
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EPHB3_HUMAN
NC score	0.057571 (rank : 258)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	225	Target Neighborhood Hits	996	Shared Neighborhood Hits	51
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

MET_HUMAN
NC score	0.057537 (rank : 259)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	225	Target Neighborhood Hits	831	Shared Neighborhood Hits	40
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHB3_MOUSE
NC score	0.057529 (rank : 260)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	225	Target Neighborhood Hits	996	Shared Neighborhood Hits	49
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FGFR4_MOUSE
NC score	0.057527 (rank : 261)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	225	Target Neighborhood Hits	1026	Shared Neighborhood Hits	43
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA8_MOUSE
NC score	0.057519 (rank : 262)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	225	Target Neighborhood Hits	969	Shared Neighborhood Hits	48
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

ROR1_MOUSE
NC score	0.057467 (rank : 263)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	225	Target Neighborhood Hits	1025	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR1_HUMAN
NC score	0.057418 (rank : 264)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	225	Target Neighborhood Hits	1018	Shared Neighborhood Hits	43
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

KIT_HUMAN
NC score	0.057314 (rank : 265)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	225	Target Neighborhood Hits	953	Shared Neighborhood Hits	43
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

EPHA8_HUMAN
NC score	0.057260 (rank : 266)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	225	Target Neighborhood Hits	956	Shared Neighborhood Hits	47
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

TYRO3_MOUSE
NC score	0.057213 (rank : 267)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	225	Target Neighborhood Hits	1007	Shared Neighborhood Hits	44
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

TYRO3_HUMAN
NC score	0.057174 (rank : 268)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	225	Target Neighborhood Hits	995	Shared Neighborhood Hits	44
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

RIN3_HUMAN
NC score	0.057098 (rank : 269)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RET_HUMAN
NC score	0.056971 (rank : 270)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	225	Target Neighborhood Hits	873	Shared Neighborhood Hits	41
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EPHB4_HUMAN
NC score	0.056861 (rank : 271)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	225	Target Neighborhood Hits	1056	Shared Neighborhood Hits	50
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

MUSK_MOUSE
NC score	0.056745 (rank : 272)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	225	Target Neighborhood Hits	1057	Shared Neighborhood Hits	42
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

EPHB4_MOUSE
NC score	0.056666 (rank : 273)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	225	Target Neighborhood Hits	1013	Shared Neighborhood Hits	50
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA5_HUMAN
NC score	0.056651 (rank : 274)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	50
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB2_HUMAN
NC score	0.056588 (rank : 275)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	225	Target Neighborhood Hits	983	Shared Neighborhood Hits	47
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

FGFR4_HUMAN
NC score	0.056577 (rank : 276)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	225	Target Neighborhood Hits	1037	Shared Neighborhood Hits	44
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

EPHB2_MOUSE
NC score	0.056516 (rank : 277)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	225	Target Neighborhood Hits	982	Shared Neighborhood Hits	47
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

SPN90_MOUSE
NC score	0.056468 (rank : 278)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	225	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RET_MOUSE
NC score	0.056447 (rank : 279)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	225	Target Neighborhood Hits	884	Shared Neighborhood Hits	41
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

DNMBP_MOUSE
NC score	0.056436 (rank : 280)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	225	Target Neighborhood Hits	435	Shared Neighborhood Hits	65
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MUSK_HUMAN
NC score	0.056248 (rank : 281)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	225	Target Neighborhood Hits	1074	Shared Neighborhood Hits	42
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

EPHB1_HUMAN
NC score	0.056178 (rank : 282)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	225	Target Neighborhood Hits	988	Shared Neighborhood Hits	49
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

OSTF1_MOUSE
NC score	0.056102 (rank : 283)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	225	Target Neighborhood Hits	467	Shared Neighborhood Hits	49
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PPIP1_MOUSE
NC score	0.056080 (rank : 284)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	225	Target Neighborhood Hits	377	Shared Neighborhood Hits	57
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

EPHA4_MOUSE
NC score	0.056072 (rank : 285)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	225	Target Neighborhood Hits	982	Shared Neighborhood Hits	47
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.056055 (rank : 286)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	47
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

STAC3_HUMAN
NC score	0.055845 (rank : 287)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	225	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PTK7_HUMAN
NC score	0.055746 (rank : 288)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	225	Target Neighborhood Hits	1103	Shared Neighborhood Hits	43
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

TEX14_HUMAN
NC score	0.055725 (rank : 289)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	225	Target Neighborhood Hits	1103	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GAK_HUMAN
NC score	0.055673 (rank : 290)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	225	Target Neighborhood Hits	1028	Shared Neighborhood Hits	59
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

M3K11_HUMAN
NC score	0.055642 (rank : 291)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	225	Target Neighborhood Hits	1136	Shared Neighborhood Hits	78
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

CD2AP_HUMAN
NC score	0.055626 (rank : 292)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	225	Target Neighborhood Hits	315	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SRRM2_HUMAN
NC score	0.055458 (rank : 293)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	225	Target Neighborhood Hits	1296	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

EPHA3_MOUSE
NC score	0.055390 (rank : 294)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	225	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

VGFR3_MOUSE
NC score	0.055372 (rank : 295)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	225	Target Neighborhood Hits	1056	Shared Neighborhood Hits	42
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR3_HUMAN
NC score	0.055326 (rank : 296)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	225	Target Neighborhood Hits	1042	Shared Neighborhood Hits	44
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

EPHA3_HUMAN
NC score	0.055311 (rank : 297)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	225	Target Neighborhood Hits	1005	Shared Neighborhood Hits	45
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA7_HUMAN
NC score	0.055306 (rank : 298)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	225	Target Neighborhood Hits	1053	Shared Neighborhood Hits	48
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

RAPH1_HUMAN
NC score	0.055289 (rank : 299)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	225	Target Neighborhood Hits	593	Shared Neighborhood Hits	59
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

M3KL4_HUMAN
NC score	0.055265 (rank : 300)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	225	Target Neighborhood Hits	1087	Shared Neighborhood Hits	67
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

EPHA7_MOUSE
NC score	0.055244 (rank : 301)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	225	Target Neighborhood Hits	1025	Shared Neighborhood Hits	47
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

NPAS4_MOUSE
NC score	0.055168 (rank : 302)	θ value	0.47712 (rank : 57)
Query Neighborhood Hits	225	Target Neighborhood Hits	245	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

VGFR3_HUMAN
NC score	0.055014 (rank : 303)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	225	Target Neighborhood Hits	1037	Shared Neighborhood Hits	42
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR3_MOUSE
NC score	0.054992 (rank : 304)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	225	Target Neighborhood Hits	1059	Shared Neighborhood Hits	43
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

STAC3_MOUSE
NC score	0.054805 (rank : 305)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	225	Target Neighborhood Hits	232	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ILK_MOUSE
NC score	0.054798 (rank : 306)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	225	Target Neighborhood Hits	858	Shared Neighborhood Hits	45
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

FGFR2_MOUSE
NC score	0.054596 (rank : 307)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	225	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR1_MOUSE
NC score	0.054565 (rank : 308)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	225	Target Neighborhood Hits	1068	Shared Neighborhood Hits	44
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
NC score	0.054555 (rank : 309)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	225	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR1_HUMAN
NC score	0.054511 (rank : 310)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	225	Target Neighborhood Hits	1069	Shared Neighborhood Hits	44
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

TIE1_HUMAN
NC score	0.054507 (rank : 311)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	225	Target Neighborhood Hits	1241	Shared Neighborhood Hits	47
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

RIN3_MOUSE
NC score	0.054459 (rank : 312)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	225	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

ILK1_HUMAN
NC score	0.054434 (rank : 313)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	225	Target Neighborhood Hits	857	Shared Neighborhood Hits	45
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

JAK1_MOUSE
NC score	0.054367 (rank : 314)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	225	Target Neighborhood Hits	854	Shared Neighborhood Hits	46
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TIE1_MOUSE
NC score	0.054165 (rank : 315)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	225	Target Neighborhood Hits	1266	Shared Neighborhood Hits	48
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EFS_MOUSE
NC score	0.054110 (rank : 316)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	225	Target Neighborhood Hits	389	Shared Neighborhood Hits	62
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

GAK_MOUSE
NC score	0.054060 (rank : 317)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	225	Target Neighborhood Hits	964	Shared Neighborhood Hits	53
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GUC2F_HUMAN
NC score	0.054044 (rank : 318)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	225	Target Neighborhood Hits	740	Shared Neighborhood Hits	41
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

VGFR2_HUMAN
NC score	0.054018 (rank : 319)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	225	Target Neighborhood Hits	1103	Shared Neighborhood Hits	44
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
NC score	0.053964 (rank : 320)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	225	Target Neighborhood Hits	1089	Shared Neighborhood Hits	44
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

M3K10_HUMAN
NC score	0.053956 (rank : 321)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	225	Target Neighborhood Hits	1071	Shared Neighborhood Hits	66
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

JAK1_HUMAN
NC score	0.053929 (rank : 322)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	225	Target Neighborhood Hits	858	Shared Neighborhood Hits	46
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

HCLS1_HUMAN
NC score	0.053883 (rank : 323)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	225	Target Neighborhood Hits	358	Shared Neighborhood Hits	62
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

TIE2_MOUSE
NC score	0.053876 (rank : 324)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	225	Target Neighborhood Hits	1204	Shared Neighborhood Hits	43
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TIE2_HUMAN
NC score	0.053857 (rank : 325)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	225	Target Neighborhood Hits	1192	Shared Neighborhood Hits	43
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

ILK2_HUMAN
NC score	0.053792 (rank : 326)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	225	Target Neighborhood Hits	848	Shared Neighborhood Hits	45
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

M3K9_HUMAN
NC score	0.053510 (rank : 327)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	225	Target Neighborhood Hits	1123	Shared Neighborhood Hits	74
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

VGFR1_MOUSE
NC score	0.053170 (rank : 328)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	225	Target Neighborhood Hits	1118	Shared Neighborhood Hits	43
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

TEX14_MOUSE
NC score	0.053078 (rank : 329)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	225	Target Neighborhood Hits	1333	Shared Neighborhood Hits	53
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MUC1_HUMAN
NC score	0.052994 (rank : 330)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	82
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

VGFR1_HUMAN
NC score	0.052875 (rank : 331)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	225	Target Neighborhood Hits	1109	Shared Neighborhood Hits	42
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

MDC1_HUMAN
NC score	0.052827 (rank : 332)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	225	Target Neighborhood Hits	1446	Shared Neighborhood Hits	92
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CD2AP_MOUSE
NC score	0.052792 (rank : 333)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	225	Target Neighborhood Hits	336	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ES8L2_MOUSE
NC score	0.052551 (rank : 334)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	225	Target Neighborhood Hits	169	Shared Neighborhood Hits	49
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

JAK3_HUMAN
NC score	0.052477 (rank : 335)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	225	Target Neighborhood Hits	827	Shared Neighborhood Hits	41
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

ANPRA_HUMAN
NC score	0.052422 (rank : 336)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	225	Target Neighborhood Hits	612	Shared Neighborhood Hits	41
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

SON_HUMAN
NC score	0.052421 (rank : 337)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	225	Target Neighborhood Hits	1568	Shared Neighborhood Hits	100
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NCF2_HUMAN
NC score	0.052289 (rank : 338)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	225	Target Neighborhood Hits	229	Shared Neighborhood Hits	42
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

TYK2_MOUSE
NC score	0.052243 (rank : 339)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	225	Target Neighborhood Hits	850	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_HUMAN
NC score	0.052044 (rank : 340)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	225	Target Neighborhood Hits	841	Shared Neighborhood Hits	42
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK2_MOUSE
NC score	0.052042 (rank : 341)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	225	Target Neighborhood Hits	839	Shared Neighborhood Hits	44
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ENAH_MOUSE
NC score	0.051928 (rank : 342)	θ value	0.813845 (rank : 76)
Query Neighborhood Hits	225	Target Neighborhood Hits	919	Shared Neighborhood Hits	59
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

BCAR1_MOUSE
NC score	0.051899 (rank : 343)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	225	Target Neighborhood Hits	438	Shared Neighborhood Hits	75
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ANPRA_MOUSE
NC score	0.051858 (rank : 344)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	225	Target Neighborhood Hits	600	Shared Neighborhood Hits	41
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

JAK2_HUMAN
NC score	0.051704 (rank : 345)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	225	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

CHIO_HUMAN
NC score	0.051360 (rank : 346)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	225	Target Neighborhood Hits	220	Shared Neighborhood Hits	54
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GUC2C_HUMAN
NC score	0.051233 (rank : 347)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	225	Target Neighborhood Hits	624	Shared Neighborhood Hits	38
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2G_MOUSE
NC score	0.051147 (rank : 348)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	225	Target Neighborhood Hits	644	Shared Neighborhood Hits	42
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ES8L2_HUMAN
NC score	0.051060 (rank : 349)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	225	Target Neighborhood Hits	193	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ALEX_HUMAN
NC score	0.051006 (rank : 350)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	225	Target Neighborhood Hits	361	Shared Neighborhood Hits	46
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

PCLO_MOUSE
NC score	0.050927 (rank : 351)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	225	Target Neighborhood Hits	2275	Shared Neighborhood Hits	105
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PACN2_HUMAN
NC score	0.050779 (rank : 352)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	225	Target Neighborhood Hits	339	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ANPRB_MOUSE
NC score	0.050727 (rank : 353)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	225	Target Neighborhood Hits	607	Shared Neighborhood Hits	43
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ES8L3_MOUSE
NC score	0.050666 (rank : 354)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	225	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ANPRB_HUMAN
NC score	0.050399 (rank : 355)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	225	Target Neighborhood Hits	646	Shared Neighborhood Hits	43
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

JAK3_MOUSE
NC score	0.050294 (rank : 356)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	225	Target Neighborhood Hits	821	Shared Neighborhood Hits	41
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

PACN2_MOUSE
NC score	0.050148 (rank : 357)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	225	Target Neighborhood Hits	382	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PAF49_MOUSE
NC score	0.050137 (rank : 358)	θ value	0.62314 (rank : 66)
Query Neighborhood Hits	225	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q76KJ5, Q8K0Y9	Gene names	Cd3eap, Ase1, Paf49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein).

MUC2_HUMAN
NC score	0.049958 (rank : 359)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	225	Target Neighborhood Hits	906	Shared Neighborhood Hits	58
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

CNOT3_HUMAN
NC score	0.049785 (rank : 360)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	225	Target Neighborhood Hits	425	Shared Neighborhood Hits	32
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

RGS3_HUMAN
NC score	0.049198 (rank : 361)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	225	Target Neighborhood Hits	1375	Shared Neighborhood Hits	88
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

WNK2_HUMAN
NC score	0.048871 (rank : 362)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	225	Target Neighborhood Hits	1407	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

RERE_MOUSE
NC score	0.048419 (rank : 363)	θ value	5.27518 (rank : 181)
Query Neighborhood Hits	225	Target Neighborhood Hits	785	Shared Neighborhood Hits	53
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SHAN1_HUMAN
NC score	0.047813 (rank : 364)	θ value	5.27518 (rank : 182)
Query Neighborhood Hits	225	Target Neighborhood Hits	1041	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

BSN_HUMAN
NC score	0.047634 (rank : 365)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	225	Target Neighborhood Hits	1537	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

MILK2_HUMAN
NC score	0.047135 (rank : 366)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	225	Target Neighborhood Hits	457	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

PCLO_HUMAN
NC score	0.046682 (rank : 367)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	225	Target Neighborhood Hits	2046	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

NHS_HUMAN
NC score	0.046316 (rank : 368)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	225	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

TP53B_MOUSE
NC score	0.046185 (rank : 369)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	225	Target Neighborhood Hits	644	Shared Neighborhood Hits	51
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TARA_HUMAN
NC score	0.046183 (rank : 370)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	225	Target Neighborhood Hits	1626	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

NU214_HUMAN
NC score	0.045248 (rank : 371)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	225	Target Neighborhood Hits	657	Shared Neighborhood Hits	50
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

DAB1_MOUSE
NC score	0.042595 (rank : 372)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	225	Target Neighborhood Hits	145	Shared Neighborhood Hits	14
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

CN155_HUMAN
NC score	0.042280 (rank : 373)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	225	Target Neighborhood Hits	385	Shared Neighborhood Hits	29
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CIC_MOUSE
NC score	0.042158 (rank : 374)	θ value	8.99809 (rank : 207)
Query Neighborhood Hits	225	Target Neighborhood Hits	742	Shared Neighborhood Hits	60
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CTND2_HUMAN
NC score	0.042044 (rank : 375)	θ value	0.0431538 (rank : 23)
Query Neighborhood Hits	225	Target Neighborhood Hits	333	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

PER3_HUMAN
NC score	0.041293 (rank : 376)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	225	Target Neighborhood Hits	479	Shared Neighborhood Hits	46
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

RTN4_HUMAN
NC score	0.041252 (rank : 377)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	225	Target Neighborhood Hits	357	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

RIMB1_HUMAN
NC score	0.040518 (rank : 378)	θ value	6.88961 (rank : 194)
Query Neighborhood Hits	225	Target Neighborhood Hits	1479	Shared Neighborhood Hits	81
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

DAB1_HUMAN
NC score	0.040413 (rank : 379)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	225	Target Neighborhood Hits	219	Shared Neighborhood Hits	32
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

RTN1_MOUSE
NC score	0.040300 (rank : 380)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	225	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

ATX2L_HUMAN
NC score	0.039196 (rank : 381)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	225	Target Neighborhood Hits	443	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

SPEG_HUMAN
NC score	0.038896 (rank : 382)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	225	Target Neighborhood Hits	1762	Shared Neighborhood Hits	96
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TFG_HUMAN
NC score	0.038199 (rank : 383)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	225	Target Neighborhood Hits	122	Shared Neighborhood Hits	13
SwissProt Accessions	Q92734, Q15656	Gene names	TFG
Domain Architecture
Description	Protein TFG (TRK-fused gene protein).

SPEG_MOUSE
NC score	0.037212 (rank : 384)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	225	Target Neighborhood Hits	1959	Shared Neighborhood Hits	114
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DDEF2_HUMAN
NC score	0.036861 (rank : 385)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	225	Target Neighborhood Hits	599	Shared Neighborhood Hits	50
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CD2L5_HUMAN
NC score	0.036232 (rank : 386)	θ value	1.06291 (rank : 82)
Query Neighborhood Hits	225	Target Neighborhood Hits	987	Shared Neighborhood Hits	49
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

EP400_MOUSE
NC score	0.034860 (rank : 387)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	225	Target Neighborhood Hits	592	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

EP400_HUMAN
NC score	0.034453 (rank : 388)	θ value	1.38821 (rank : 92)
Query Neighborhood Hits	225	Target Neighborhood Hits	556	Shared Neighborhood Hits	40
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

SET1A_HUMAN
NC score	0.034406 (rank : 389)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	225	Target Neighborhood Hits	690	Shared Neighborhood Hits	37
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

HSF1_MOUSE
NC score	0.034119 (rank : 390)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	225	Target Neighborhood Hits	267	Shared Neighborhood Hits	36
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

JIP1_HUMAN
NC score	0.034097 (rank : 391)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	225	Target Neighborhood Hits	271	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PDZD2_HUMAN
NC score	0.033795 (rank : 392)	θ value	6.88961 (rank : 190)
Query Neighborhood Hits	225	Target Neighborhood Hits	772	Shared Neighborhood Hits	60
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

MILK1_HUMAN
NC score	0.033763 (rank : 393)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	225	Target Neighborhood Hits	427	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PRG4_MOUSE
NC score	0.033686 (rank : 394)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	225	Target Neighborhood Hits	624	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

TRIO_HUMAN
NC score	0.033216 (rank : 395)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	225	Target Neighborhood Hits	1580	Shared Neighborhood Hits	71
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

VGF_HUMAN
NC score	0.031552 (rank : 396)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	225	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

PININ_MOUSE
NC score	0.030859 (rank : 397)	θ value	5.27518 (rank : 179)
Query Neighborhood Hits	225	Target Neighborhood Hits	777	Shared Neighborhood Hits	18
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

ACINU_HUMAN
NC score	0.030680 (rank : 398)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	225	Target Neighborhood Hits	828	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

3BP1_HUMAN
NC score	0.030043 (rank : 399)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	225	Target Neighborhood Hits	376	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

PI5PA_MOUSE
NC score	0.029680 (rank : 400)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	225	Target Neighborhood Hits	331	Shared Neighborhood Hits	36
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

CD248_MOUSE
NC score	0.028876 (rank : 401)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	225	Target Neighborhood Hits	578	Shared Neighborhood Hits	43
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

PININ_HUMAN
NC score	0.028711 (rank : 402)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	225	Target Neighborhood Hits	753	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

CSKI1_MOUSE
NC score	0.028698 (rank : 403)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	225	Target Neighborhood Hits	1031	Shared Neighborhood Hits	72
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI2_MOUSE
NC score	0.028300 (rank : 404)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	225	Target Neighborhood Hits	812	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

RGNEF_MOUSE
NC score	0.027948 (rank : 405)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	225	Target Neighborhood Hits	641	Shared Neighborhood Hits	19
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

CBL_MOUSE
NC score	0.027016 (rank : 406)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	225	Target Neighborhood Hits	426	Shared Neighborhood Hits	34
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

HN1L_HUMAN
NC score	0.026955 (rank : 407)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	225	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

DDFL1_HUMAN
NC score	0.026509 (rank : 408)	θ value	0.62314 (rank : 64)
Query Neighborhood Hits	225	Target Neighborhood Hits	353	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

EPN4_MOUSE
NC score	0.026389 (rank : 409)	θ value	1.38821 (rank : 93)
Query Neighborhood Hits	225	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q99KN9, Q8CFH4	Gene names	Clint1, Enth, Epn4, Epnr, Kiaa0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin).

TAB3_HUMAN
NC score	0.026335 (rank : 410)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	225	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

PITM1_HUMAN
NC score	0.026272 (rank : 411)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	225	Target Neighborhood Hits	129	Shared Neighborhood Hits	13
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

IRS2_HUMAN
NC score	0.025817 (rank : 412)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	225	Target Neighborhood Hits	262	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

GAB2_MOUSE
NC score	0.025647 (rank : 413)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	225	Target Neighborhood Hits	220	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

CUTL1_MOUSE
NC score	0.025587 (rank : 414)	θ value	0.813845 (rank : 75)
Query Neighborhood Hits	225	Target Neighborhood Hits	1620	Shared Neighborhood Hits	52
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

BRD4_MOUSE
NC score	0.025509 (rank : 415)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	225	Target Neighborhood Hits	845	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

AFF1_HUMAN
NC score	0.025163 (rank : 416)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	225	Target Neighborhood Hits	506	Shared Neighborhood Hits	32
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

PHC1_HUMAN
NC score	0.024759 (rank : 417)	θ value	5.27518 (rank : 177)
Query Neighborhood Hits	225	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

FOXL2_MOUSE
NC score	0.024718 (rank : 418)	θ value	0.21417 (rank : 42)
Query Neighborhood Hits	225	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	O88470, Q8K3X9	Gene names	Foxl2, Pfrk
Domain Architecture	No domain graphic available
Description	Forkhead box protein L2 (Pituitary forkhead factor) (P-Frk).

MAST3_HUMAN
NC score	0.023946 (rank : 419)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	225	Target Neighborhood Hits	1128	Shared Neighborhood Hits	71
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MUC15_HUMAN
NC score	0.023709 (rank : 420)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	225	Target Neighborhood Hits	61	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N387, Q6UWS3, Q8IXI8, Q8WW41	Gene names	MUC15
Domain Architecture	No domain graphic available
Description	Mucin-15 precursor.

CUTL1_HUMAN
NC score	0.023684 (rank : 421)	θ value	0.47712 (rank : 54)
Query Neighborhood Hits	225	Target Neighborhood Hits	1574	Shared Neighborhood Hits	43
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

R3HD1_HUMAN
NC score	0.023656 (rank : 422)	θ value	6.88961 (rank : 193)
Query Neighborhood Hits	225	Target Neighborhood Hits	203	Shared Neighborhood Hits	17
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

FOXL2_HUMAN
NC score	0.023598 (rank : 423)	θ value	0.21417 (rank : 41)
Query Neighborhood Hits	225	Target Neighborhood Hits	142	Shared Neighborhood Hits	7
SwissProt Accessions	P58012, Q4ZGJ3	Gene names	FOXL2
Domain Architecture
Description	Forkhead box protein L2.

RSMN_HUMAN
NC score	0.023280 (rank : 424)	θ value	6.88961 (rank : 195)
Query Neighborhood Hits	225	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
NC score	0.023280 (rank : 425)	θ value	6.88961 (rank : 196)
Query Neighborhood Hits	225	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

K2002_MOUSE
NC score	0.022761 (rank : 426)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	225	Target Neighborhood Hits	267	Shared Neighborhood Hits	9
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NCA11_MOUSE
NC score	0.022535 (rank : 427)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	225	Target Neighborhood Hits	661	Shared Neighborhood Hits	28
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CBL_HUMAN
NC score	0.021885 (rank : 428)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	225	Target Neighborhood Hits	353	Shared Neighborhood Hits	24
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

HNRPG_MOUSE
NC score	0.021519 (rank : 429)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	225	Target Neighborhood Hits	223	Shared Neighborhood Hits	7
SwissProt Accessions	O35479	Gene names	Rbmx, Hnrnpg, Hnrpg, Rbmxp1, Rbmxrt
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome).

SHAN2_HUMAN
NC score	0.020840 (rank : 430)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	225	Target Neighborhood Hits	346	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

HNRPG_HUMAN
NC score	0.020697 (rank : 431)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	225	Target Neighborhood Hits	245	Shared Neighborhood Hits	9
SwissProt Accessions	P38159, Q5JQ67, Q969R3	Gene names	RBMX, HNRPG, RBMXP1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome) (Glycoprotein p43).

ATF2_MOUSE
NC score	0.020442 (rank : 432)	θ value	6.88961 (rank : 185)
Query Neighborhood Hits	225	Target Neighborhood Hits	397	Shared Neighborhood Hits	29
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

ANKS1_MOUSE
NC score	0.020408 (rank : 433)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	225	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ATF2_HUMAN
NC score	0.019619 (rank : 434)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	225	Target Neighborhood Hits	402	Shared Neighborhood Hits	29
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

POGZ_HUMAN
NC score	0.019605 (rank : 435)	θ value	0.0961366 (rank : 33)
Query Neighborhood Hits	225	Target Neighborhood Hits	745	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z3K3, O75049, Q8TDZ7, Q9Y4X7	Gene names	POGZ, KIAA0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

NFAC3_HUMAN
NC score	0.019033 (rank : 436)	θ value	5.27518 (rank : 173)
Query Neighborhood Hits	225	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

FA53B_MOUSE
NC score	0.018652 (rank : 437)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	225	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGR5, Q3UGW1, Q8BI13	Gene names	Fam53b
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

ANKS1_HUMAN
NC score	0.018478 (rank : 438)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	225	Target Neighborhood Hits	438	Shared Neighborhood Hits	15
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

USH1C_MOUSE
NC score	0.018191 (rank : 439)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	225	Target Neighborhood Hits	557	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

CSTF2_HUMAN
NC score	0.018011 (rank : 440)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	225	Target Neighborhood Hits	296	Shared Neighborhood Hits	12
SwissProt Accessions	P33240, Q5H951, Q6LA74, Q8N502	Gene names	CSTF2
Domain Architecture
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

ZAN_HUMAN
NC score	0.017960 (rank : 441)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	225	Target Neighborhood Hits	679	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

NFAC3_MOUSE
NC score	0.017898 (rank : 442)	θ value	5.27518 (rank : 174)
Query Neighborhood Hits	225	Target Neighborhood Hits	106	Shared Neighborhood Hits	11
SwissProt Accessions	P97305, Q60896	Gene names	Nfatc3, Nfat4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

POGZ_MOUSE
NC score	0.016254 (rank : 443)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	225	Target Neighborhood Hits	765	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZH4, Q4VA94, Q80TZ8, Q8C0K1, Q8K294	Gene names	Pogz, Kiaa0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

MEF2D_MOUSE
NC score	0.015412 (rank : 444)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	225	Target Neighborhood Hits	146	Shared Neighborhood Hits	12
SwissProt Accessions	Q63943, Q63944	Gene names	Mef2d
Domain Architecture
Description	Myocyte-specific enhancer factor 2D.

CAF1B_HUMAN
NC score	0.015312 (rank : 445)	θ value	1.06291 (rank : 81)
Query Neighborhood Hits	225	Target Neighborhood Hits	345	Shared Neighborhood Hits	9
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

PITM1_MOUSE
NC score	0.014441 (rank : 446)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	225	Target Neighborhood Hits	69	Shared Neighborhood Hits	10
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

ATF6B_MOUSE
NC score	0.014086 (rank : 447)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	225	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

ZN318_HUMAN
NC score	0.013834 (rank : 448)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	225	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

DYN1_HUMAN
NC score	0.013413 (rank : 449)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	225	Target Neighborhood Hits	216	Shared Neighborhood Hits	16
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

GP152_HUMAN
NC score	0.012863 (rank : 450)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	225	Target Neighborhood Hits	636	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

K1849_MOUSE
NC score	0.012842 (rank : 451)	θ value	6.88961 (rank : 187)
Query Neighborhood Hits	225	Target Neighborhood Hits	335	Shared Neighborhood Hits	18
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LBXCO_HUMAN
NC score	0.012582 (rank : 452)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	225	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

IRX1_HUMAN
NC score	0.012572 (rank : 453)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	225	Target Neighborhood Hits	285	Shared Neighborhood Hits	7
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

SSPO_MOUSE
NC score	0.012335 (rank : 454)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	225	Target Neighborhood Hits	800	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ZBTB4_HUMAN
NC score	0.011245 (rank : 455)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	225	Target Neighborhood Hits	926	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

ZN687_MOUSE
NC score	0.011236 (rank : 456)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	225	Target Neighborhood Hits	913	Shared Neighborhood Hits	34
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

AAKG2_MOUSE
NC score	0.010263 (rank : 457)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	225	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG5, Q6V7V5	Gene names	Prkag2
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma-2 chain) (AMPK gamma2).

RXRA_HUMAN
NC score	0.010124 (rank : 458)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	225	Target Neighborhood Hits	223	Shared Neighborhood Hits	19
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

CHKA_HUMAN
NC score	0.009784 (rank : 459)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	225	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P35790, Q8NE29	Gene names	CHKA, CHK, CKI
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

ROBO3_MOUSE
NC score	0.009127 (rank : 460)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	225	Target Neighborhood Hits	524	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

MCR_MOUSE
NC score	0.009068 (rank : 461)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	225	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PAPOG_MOUSE
NC score	0.008571 (rank : 462)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	225	Target Neighborhood Hits	103	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PCL9, Q8BZC9	Gene names	Papolg
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme).

KLF17_HUMAN
NC score	0.007237 (rank : 463)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	225	Target Neighborhood Hits	882	Shared Neighborhood Hits	41
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

EYA2_MOUSE
NC score	0.007171 (rank : 464)	θ value	8.99809 (rank : 209)
Query Neighborhood Hits	225	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	O08575, P97925	Gene names	Eya2, Eab1
Domain Architecture
Description	Eyes absent homolog 2 (EC 3.1.3.48).

NMDE3_MOUSE
NC score	0.006397 (rank : 465)	θ value	5.27518 (rank : 175)
Query Neighborhood Hits	225	Target Neighborhood Hits	86	Shared Neighborhood Hits	6
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

PHLPL_HUMAN
NC score	0.004333 (rank : 466)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	225	Target Neighborhood Hits	310	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

NOTC3_MOUSE
NC score	0.003849 (rank : 467)	θ value	5.27518 (rank : 176)
Query Neighborhood Hits	225	Target Neighborhood Hits	975	Shared Neighborhood Hits	23
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

GLIS1_HUMAN
NC score	0.002779 (rank : 468)	θ value	1.38821 (rank : 94)
Query Neighborhood Hits	225	Target Neighborhood Hits	748	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

DLX2_HUMAN
NC score	0.001979 (rank : 469)	θ value	8.99809 (rank : 208)
Query Neighborhood Hits	225	Target Neighborhood Hits	355	Shared Neighborhood Hits	7
SwissProt Accessions	Q07687	Gene names	DLX2
Domain Architecture
Description	Homeobox protein DLX-2.

ZN366_HUMAN
NC score	-0.001368 (rank : 470)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	225	Target Neighborhood Hits	732	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N895, Q7RTV4	Gene names	ZNF366
Domain Architecture	No domain graphic available
Description	Zinc finger protein 366.