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Network neighborhood for query Sequence : AATK_HUMAN

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AATK_HUMAN
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AATK_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1243	Shared Neighborhood Hits	1243
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	0 (rank : 2)	NC score	0.976653 (rank : 2)
Query Neighborhood Hits	1243	Target Neighborhood Hits	942	Shared Neighborhood Hits	810
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

PTK7_HUMAN
θ value	1.12253e-42 (rank : 3)	NC score	0.842273 (rank : 199)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1103	Shared Neighborhood Hits	727
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

INSR_HUMAN
θ value	7.27602e-42 (rank : 4)	NC score	0.930358 (rank : 5)
Query Neighborhood Hits	1243	Target Neighborhood Hits	963	Shared Neighborhood Hits	749
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	3.05695e-40 (rank : 5)	NC score	0.928931 (rank : 6)
Query Neighborhood Hits	1243	Target Neighborhood Hits	968	Shared Neighborhood Hits	746
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

NTRK2_MOUSE
θ value	5.76516e-39 (rank : 6)	NC score	0.913891 (rank : 61)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1088	Shared Neighborhood Hits	752
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
θ value	7.52953e-39 (rank : 7)	NC score	0.914030 (rank : 60)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1081	Shared Neighborhood Hits	750
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

IGF1R_HUMAN
θ value	2.86122e-38 (rank : 8)	NC score	0.926160 (rank : 17)
Query Neighborhood Hits	1243	Target Neighborhood Hits	977	Shared Neighborhood Hits	742
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	3.73686e-38 (rank : 9)	NC score	0.926767 (rank : 13)
Query Neighborhood Hits	1243	Target Neighborhood Hits	973	Shared Neighborhood Hits	743
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ALK_MOUSE
θ value	1.42001e-37 (rank : 10)	NC score	0.924062 (rank : 23)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	710
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_HUMAN
θ value	2.42216e-37 (rank : 11)	NC score	0.923552 (rank : 25)
Query Neighborhood Hits	1243	Target Neighborhood Hits	795	Shared Neighborhood Hits	700
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

DDR2_MOUSE
θ value	5.39604e-37 (rank : 12)	NC score	0.918652 (rank : 45)
Query Neighborhood Hits	1243	Target Neighborhood Hits	813	Shared Neighborhood Hits	730
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_HUMAN
θ value	9.20422e-37 (rank : 13)	NC score	0.918259 (rank : 48)
Query Neighborhood Hits	1243	Target Neighborhood Hits	818	Shared Neighborhood Hits	730
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ROS_HUMAN
θ value	9.20422e-37 (rank : 14)	NC score	0.921199 (rank : 30)
Query Neighborhood Hits	1243	Target Neighborhood Hits	907	Shared Neighborhood Hits	721
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

INSRR_MOUSE
θ value	2.67802e-36 (rank : 15)	NC score	0.926302 (rank : 14)
Query Neighborhood Hits	1243	Target Neighborhood Hits	961	Shared Neighborhood Hits	739
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

LTK_HUMAN
θ value	7.79185e-36 (rank : 16)	NC score	0.922134 (rank : 26)
Query Neighborhood Hits	1243	Target Neighborhood Hits	774	Shared Neighborhood Hits	702
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

INSRR_HUMAN
θ value	1.32909e-35 (rank : 17)	NC score	0.924711 (rank : 22)
Query Neighborhood Hits	1243	Target Neighborhood Hits	950	Shared Neighborhood Hits	742
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

MUSK_HUMAN
θ value	2.26708e-35 (rank : 18)	NC score	0.863401 (rank : 179)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1074	Shared Neighborhood Hits	739
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

NTRK1_HUMAN
θ value	3.27365e-34 (rank : 19)	NC score	0.923718 (rank : 24)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1023	Shared Neighborhood Hits	743
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

MUSK_MOUSE
θ value	7.29293e-34 (rank : 20)	NC score	0.860968 (rank : 181)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1057	Shared Neighborhood Hits	737
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

LTK_MOUSE
θ value	8.06329e-33 (rank : 21)	NC score	0.920562 (rank : 35)
Query Neighborhood Hits	1243	Target Neighborhood Hits	770	Shared Neighborhood Hits	702
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

UFO_MOUSE
θ value	4.00176e-32 (rank : 22)	NC score	0.910139 (rank : 80)
Query Neighborhood Hits	1243	Target Neighborhood Hits	988	Shared Neighborhood Hits	717
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

BMX_HUMAN
θ value	5.22648e-32 (rank : 23)	NC score	0.926161 (rank : 16)
Query Neighborhood Hits	1243	Target Neighborhood Hits	942	Shared Neighborhood Hits	745
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

NTRK3_HUMAN
θ value	1.16434e-31 (rank : 24)	NC score	0.907664 (rank : 96)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1115	Shared Neighborhood Hits	744
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

ABL1_MOUSE
θ value	1.52067e-31 (rank : 25)	NC score	0.916170 (rank : 53)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1178	Shared Neighborhood Hits	812
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BMX_MOUSE
θ value	1.52067e-31 (rank : 26)	NC score	0.927023 (rank : 12)
Query Neighborhood Hits	1243	Target Neighborhood Hits	912	Shared Neighborhood Hits	741
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

UFO_HUMAN
θ value	3.3877e-31 (rank : 27)	NC score	0.911436 (rank : 74)
Query Neighborhood Hits	1243	Target Neighborhood Hits	981	Shared Neighborhood Hits	715
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

FES_HUMAN
θ value	4.42448e-31 (rank : 28)	NC score	0.928412 (rank : 10)
Query Neighborhood Hits	1243	Target Neighborhood Hits	978	Shared Neighborhood Hits	751
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TEC_HUMAN
θ value	1.28732e-30 (rank : 29)	NC score	0.918865 (rank : 43)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1006	Shared Neighborhood Hits	760
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FES_MOUSE
θ value	1.6813e-30 (rank : 30)	NC score	0.928744 (rank : 8)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	753
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TXK_HUMAN
θ value	2.19584e-30 (rank : 31)	NC score	0.920440 (rank : 38)
Query Neighborhood Hits	1243	Target Neighborhood Hits	971	Shared Neighborhood Hits	753
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

DDR1_MOUSE
θ value	3.74554e-30 (rank : 32)	NC score	0.920288 (rank : 39)
Query Neighborhood Hits	1243	Target Neighborhood Hits	818	Shared Neighborhood Hits	730
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

RYK_HUMAN
θ value	3.74554e-30 (rank : 33)	NC score	0.911347 (rank : 75)
Query Neighborhood Hits	1243	Target Neighborhood Hits	701	Shared Neighborhood Hits	661
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	3.74554e-30 (rank : 34)	NC score	0.916675 (rank : 52)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	672
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ROR1_HUMAN
θ value	4.89182e-30 (rank : 35)	NC score	0.907943 (rank : 93)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1018	Shared Neighborhood Hits	748
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TEC_MOUSE
θ value	4.89182e-30 (rank : 36)	NC score	0.918805 (rank : 44)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1006	Shared Neighborhood Hits	760
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MET_MOUSE
θ value	8.3442e-30 (rank : 37)	NC score	0.920108 (rank : 40)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	743
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ABL1_HUMAN
θ value	1.08979e-29 (rank : 38)	NC score	0.915294 (rank : 56)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1220	Shared Neighborhood Hits	820
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

MERTK_HUMAN
θ value	1.4233e-29 (rank : 39)	NC score	0.909182 (rank : 87)
Query Neighborhood Hits	1243	Target Neighborhood Hits	988	Shared Neighborhood Hits	731
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	1.85889e-29 (rank : 40)	NC score	0.919031 (rank : 42)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	742
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

DDR1_HUMAN
θ value	2.42779e-29 (rank : 41)	NC score	0.918596 (rank : 46)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	731
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

TXK_MOUSE
θ value	3.17079e-29 (rank : 42)	NC score	0.921057 (rank : 32)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	755
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ROR1_MOUSE
θ value	4.14116e-29 (rank : 43)	NC score	0.907923 (rank : 94)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1025	Shared Neighborhood Hits	751
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

FGFR3_HUMAN
θ value	7.06379e-29 (rank : 44)	NC score	0.902787 (rank : 106)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1042	Shared Neighborhood Hits	755
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ABL2_HUMAN
θ value	9.2256e-29 (rank : 45)	NC score	0.915939 (rank : 54)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1045	Shared Neighborhood Hits	770
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

FGFR1_HUMAN
θ value	2.68423e-28 (rank : 46)	NC score	0.901065 (rank : 113)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1069	Shared Neighborhood Hits	760
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	2.68423e-28 (rank : 47)	NC score	0.901301 (rank : 112)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1068	Shared Neighborhood Hits	760
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

ROR2_HUMAN
θ value	2.68423e-28 (rank : 48)	NC score	0.902628 (rank : 107)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1014	Shared Neighborhood Hits	738
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ITK_MOUSE
θ value	3.50572e-28 (rank : 49)	NC score	0.920533 (rank : 36)
Query Neighborhood Hits	1243	Target Neighborhood Hits	985	Shared Neighborhood Hits	759
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

FGFR4_HUMAN
θ value	7.80994e-28 (rank : 50)	NC score	0.898024 (rank : 119)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1037	Shared Neighborhood Hits	752
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FYN_HUMAN
θ value	1.02001e-27 (rank : 51)	NC score	0.902196 (rank : 110)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1078	Shared Neighborhood Hits	765
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

RET_MOUSE
θ value	1.02001e-27 (rank : 52)	NC score	0.931099 (rank : 4)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	747
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MERTK_MOUSE
θ value	1.33217e-27 (rank : 53)	NC score	0.911271 (rank : 76)
Query Neighborhood Hits	1243	Target Neighborhood Hits	974	Shared Neighborhood Hits	718
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FRK_HUMAN
θ value	1.73987e-27 (rank : 54)	NC score	0.915769 (rank : 55)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1058	Shared Neighborhood Hits	763
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

RET_HUMAN
θ value	1.73987e-27 (rank : 55)	NC score	0.931783 (rank : 3)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	746
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ITK_HUMAN
θ value	2.27234e-27 (rank : 56)	NC score	0.919587 (rank : 41)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1016	Shared Neighborhood Hits	759
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

RON_MOUSE
θ value	2.27234e-27 (rank : 57)	NC score	0.921412 (rank : 29)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FYN_MOUSE
θ value	2.96777e-27 (rank : 58)	NC score	0.902998 (rank : 105)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1073	Shared Neighborhood Hits	766
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LYN_MOUSE
θ value	3.87602e-27 (rank : 59)	NC score	0.911573 (rank : 73)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1023	Shared Neighborhood Hits	764
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FGFR4_MOUSE
θ value	5.06226e-27 (rank : 60)	NC score	0.894357 (rank : 124)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1026	Shared Neighborhood Hits	738
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LYN_HUMAN
θ value	5.06226e-27 (rank : 61)	NC score	0.911866 (rank : 70)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1022	Shared Neighborhood Hits	763
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ACK1_MOUSE
θ value	8.63488e-27 (rank : 62)	NC score	0.925925 (rank : 18)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1080	Shared Neighborhood Hits	844
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ROR2_MOUSE
θ value	8.63488e-27 (rank : 63)	NC score	0.896958 (rank : 122)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1000	Shared Neighborhood Hits	725
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

TYRO3_HUMAN
θ value	8.63488e-27 (rank : 64)	NC score	0.899855 (rank : 116)
Query Neighborhood Hits	1243	Target Neighborhood Hits	995	Shared Neighborhood Hits	726
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	1.12775e-26 (rank : 65)	NC score	0.901031 (rank : 114)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1007	Shared Neighborhood Hits	727
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

BTK_HUMAN
θ value	2.51237e-26 (rank : 66)	NC score	0.912349 (rank : 68)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1026	Shared Neighborhood Hits	755
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ACK1_HUMAN
θ value	3.28125e-26 (rank : 67)	NC score	0.925079 (rank : 21)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1140	Shared Neighborhood Hits	865
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

RON_HUMAN
θ value	3.28125e-26 (rank : 68)	NC score	0.920528 (rank : 37)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	750
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

BTK_MOUSE
θ value	4.28545e-26 (rank : 69)	NC score	0.912692 (rank : 66)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1017	Shared Neighborhood Hits	756
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FER_HUMAN
θ value	5.59698e-26 (rank : 70)	NC score	0.913098 (rank : 64)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1278	Shared Neighborhood Hits	761
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGFR2_HUMAN
θ value	5.59698e-26 (rank : 71)	NC score	0.904126 (rank : 101)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1062	Shared Neighborhood Hits	756
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	5.59698e-26 (rank : 72)	NC score	0.906985 (rank : 99)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1062	Shared Neighborhood Hits	756
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGR_MOUSE
θ value	5.59698e-26 (rank : 73)	NC score	0.897480 (rank : 120)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1069	Shared Neighborhood Hits	763
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGFR3_MOUSE
θ value	7.30988e-26 (rank : 74)	NC score	0.898576 (rank : 117)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1059	Shared Neighborhood Hits	752
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

STYK1_MOUSE
θ value	9.54697e-26 (rank : 75)	NC score	0.926285 (rank : 15)
Query Neighborhood Hits	1243	Target Neighborhood Hits	779	Shared Neighborhood Hits	722
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

FGR_HUMAN
θ value	1.24688e-25 (rank : 76)	NC score	0.898558 (rank : 118)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1067	Shared Neighborhood Hits	763
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

STYK1_HUMAN
θ value	2.77775e-25 (rank : 77)	NC score	0.927309 (rank : 11)
Query Neighborhood Hits	1243	Target Neighborhood Hits	786	Shared Neighborhood Hits	723
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

SRMS_MOUSE
θ value	3.62785e-25 (rank : 78)	NC score	0.921120 (rank : 31)
Query Neighborhood Hits	1243	Target Neighborhood Hits	964	Shared Neighborhood Hits	757
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

HCK_HUMAN
θ value	8.08199e-25 (rank : 79)	NC score	0.908707 (rank : 89)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1035	Shared Neighborhood Hits	762
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

YES_HUMAN
θ value	8.08199e-25 (rank : 80)	NC score	0.903182 (rank : 103)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1059	Shared Neighborhood Hits	763
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PTK6_MOUSE
θ value	1.05554e-24 (rank : 81)	NC score	0.913107 (rank : 63)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1026	Shared Neighborhood Hits	758
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SRC_HUMAN
θ value	1.05554e-24 (rank : 82)	NC score	0.905882 (rank : 100)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1058	Shared Neighborhood Hits	769
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_MOUSE
θ value	1.05554e-24 (rank : 83)	NC score	0.903077 (rank : 104)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1052	Shared Neighborhood Hits	762
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PTK6_HUMAN
θ value	1.37858e-24 (rank : 84)	NC score	0.912571 (rank : 67)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1020	Shared Neighborhood Hits	758
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TIE2_MOUSE
θ value	2.35151e-24 (rank : 85)	NC score	0.890841 (rank : 135)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1204	Shared Neighborhood Hits	763
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

CSK_HUMAN
θ value	3.07116e-24 (rank : 86)	NC score	0.916714 (rank : 51)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	761
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

EPHA2_HUMAN
θ value	3.07116e-24 (rank : 87)	NC score	0.901452 (rank : 111)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1021	Shared Neighborhood Hits	767
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

HCK_MOUSE
θ value	3.07116e-24 (rank : 88)	NC score	0.909491 (rank : 86)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1029	Shared Neighborhood Hits	761
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SRC_MOUSE
θ value	3.07116e-24 (rank : 89)	NC score	0.908557 (rank : 90)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1033	Shared Neighborhood Hits	769
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TIE1_HUMAN
θ value	4.01107e-24 (rank : 90)	NC score	0.882295 (rank : 159)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1241	Shared Neighborhood Hits	761
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	4.01107e-24 (rank : 91)	NC score	0.881831 (rank : 160)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1266	Shared Neighborhood Hits	764
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	8.93572e-24 (rank : 92)	NC score	0.895088 (rank : 123)
Query Neighborhood Hits	1243	Target Neighborhood Hits	988	Shared Neighborhood Hits	755
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA2_MOUSE
θ value	1.16704e-23 (rank : 93)	NC score	0.902304 (rank : 109)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1020	Shared Neighborhood Hits	766
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FAK1_HUMAN
θ value	1.5242e-23 (rank : 94)	NC score	0.928755 (rank : 7)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	763
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	1.5242e-23 (rank : 95)	NC score	0.928623 (rank : 9)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	760
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

TIE2_HUMAN
θ value	1.5242e-23 (rank : 96)	NC score	0.891061 (rank : 133)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1192	Shared Neighborhood Hits	761
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

SRMS_HUMAN
θ value	7.56453e-23 (rank : 97)	NC score	0.921030 (rank : 33)
Query Neighborhood Hits	1243	Target Neighborhood Hits	946	Shared Neighborhood Hits	756
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

BLK_HUMAN
θ value	1.29031e-22 (rank : 98)	NC score	0.911182 (rank : 77)
Query Neighborhood Hits	1243	Target Neighborhood Hits	994	Shared Neighborhood Hits	759
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CSK_MOUSE
θ value	1.29031e-22 (rank : 99)	NC score	0.914614 (rank : 59)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	761
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

EPHB2_MOUSE
θ value	2.20094e-22 (rank : 100)	NC score	0.892038 (rank : 130)
Query Neighborhood Hits	1243	Target Neighborhood Hits	982	Shared Neighborhood Hits	756
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA1_HUMAN
θ value	2.87452e-22 (rank : 101)	NC score	0.904003 (rank : 102)
Query Neighborhood Hits	1243	Target Neighborhood Hits	997	Shared Neighborhood Hits	755
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHB2_HUMAN
θ value	2.87452e-22 (rank : 102)	NC score	0.891852 (rank : 131)
Query Neighborhood Hits	1243	Target Neighborhood Hits	983	Shared Neighborhood Hits	756
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

LCK_HUMAN
θ value	8.36355e-22 (rank : 103)	NC score	0.911835 (rank : 71)
Query Neighborhood Hits	1243	Target Neighborhood Hits	987	Shared Neighborhood Hits	765
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	8.36355e-22 (rank : 104)	NC score	0.912255 (rank : 69)
Query Neighborhood Hits	1243	Target Neighborhood Hits	981	Shared Neighborhood Hits	763
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BLK_MOUSE
θ value	1.42661e-21 (rank : 105)	NC score	0.910642 (rank : 79)
Query Neighborhood Hits	1243	Target Neighborhood Hits	992	Shared Neighborhood Hits	761
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

KSYK_HUMAN
θ value	1.42661e-21 (rank : 106)	NC score	0.915150 (rank : 57)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	756
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

EPHA1_MOUSE
θ value	4.15078e-21 (rank : 107)	NC score	0.902352 (rank : 108)
Query Neighborhood Hits	1243	Target Neighborhood Hits	958	Shared Neighborhood Hits	747
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA3_MOUSE
θ value	4.15078e-21 (rank : 108)	NC score	0.892274 (rank : 129)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	765
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ERBB3_HUMAN
θ value	4.15078e-21 (rank : 109)	NC score	0.907533 (rank : 97)
Query Neighborhood Hits	1243	Target Neighborhood Hits	918	Shared Neighborhood Hits	732
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

MATK_HUMAN
θ value	5.42112e-21 (rank : 110)	NC score	0.922104 (rank : 27)
Query Neighborhood Hits	1243	Target Neighborhood Hits	954	Shared Neighborhood Hits	760
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

EPHB3_HUMAN
θ value	9.24701e-21 (rank : 111)	NC score	0.888400 (rank : 146)
Query Neighborhood Hits	1243	Target Neighborhood Hits	996	Shared Neighborhood Hits	759
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

KSYK_MOUSE
θ value	9.24701e-21 (rank : 112)	NC score	0.914631 (rank : 58)
Query Neighborhood Hits	1243	Target Neighborhood Hits	944	Shared Neighborhood Hits	770
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

VGFR1_MOUSE
θ value	9.24701e-21 (rank : 113)	NC score	0.853928 (rank : 190)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1118	Shared Neighborhood Hits	752
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

EPHB3_MOUSE
θ value	1.2077e-20 (rank : 114)	NC score	0.888339 (rank : 147)
Query Neighborhood Hits	1243	Target Neighborhood Hits	996	Shared Neighborhood Hits	762
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

MATK_MOUSE
θ value	1.2077e-20 (rank : 115)	NC score	0.920942 (rank : 34)
Query Neighborhood Hits	1243	Target Neighborhood Hits	952	Shared Neighborhood Hits	759
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ERBB4_HUMAN
θ value	1.5773e-20 (rank : 116)	NC score	0.913821 (rank : 62)
Query Neighborhood Hits	1243	Target Neighborhood Hits	910	Shared Neighborhood Hits	751
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ZAP70_HUMAN
θ value	1.5773e-20 (rank : 117)	NC score	0.916933 (rank : 49)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	751
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

EPHA3_HUMAN
θ value	2.69047e-20 (rank : 118)	NC score	0.894171 (rank : 125)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1005	Shared Neighborhood Hits	761
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHB4_HUMAN
θ value	2.69047e-20 (rank : 119)	NC score	0.893162 (rank : 128)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1056	Shared Neighborhood Hits	753
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ERBB3_MOUSE
θ value	2.69047e-20 (rank : 120)	NC score	0.911162 (rank : 78)
Query Neighborhood Hits	1243	Target Neighborhood Hits	898	Shared Neighborhood Hits	737
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

VGFR2_HUMAN
θ value	3.51386e-20 (rank : 121)	NC score	0.853646 (rank : 191)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1103	Shared Neighborhood Hits	744
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

EPHB4_MOUSE
θ value	5.99374e-20 (rank : 122)	NC score	0.893344 (rank : 127)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1013	Shared Neighborhood Hits	752
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA7_HUMAN
θ value	1.02238e-19 (rank : 123)	NC score	0.888537 (rank : 144)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1053	Shared Neighborhood Hits	762
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	1.02238e-19 (rank : 124)	NC score	0.889408 (rank : 141)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1025	Shared Neighborhood Hits	761
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

ZAP70_MOUSE
θ value	1.02238e-19 (rank : 125)	NC score	0.916846 (rank : 50)
Query Neighborhood Hits	1243	Target Neighborhood Hits	905	Shared Neighborhood Hits	753
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

JAK1_MOUSE
θ value	1.74391e-19 (rank : 126)	NC score	0.909899 (rank : 82)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	756
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TYK2_HUMAN
θ value	1.74391e-19 (rank : 127)	NC score	0.911734 (rank : 72)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	761
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

CSF1R_MOUSE
θ value	2.27762e-19 (rank : 128)	NC score	0.880432 (rank : 164)
Query Neighborhood Hits	1243	Target Neighborhood Hits	983	Shared Neighborhood Hits	737
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EGFR_HUMAN
θ value	2.27762e-19 (rank : 129)	NC score	0.909727 (rank : 84)
Query Neighborhood Hits	1243	Target Neighborhood Hits	939	Shared Neighborhood Hits	751
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EPHA5_HUMAN
θ value	2.27762e-19 (rank : 130)	NC score	0.891398 (rank : 132)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	763
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PGFRB_HUMAN
θ value	2.27762e-19 (rank : 131)	NC score	0.886367 (rank : 151)
Query Neighborhood Hits	1243	Target Neighborhood Hits	962	Shared Neighborhood Hits	742
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EGFR_MOUSE
θ value	2.97466e-19 (rank : 132)	NC score	0.909967 (rank : 81)
Query Neighborhood Hits	1243	Target Neighborhood Hits	927	Shared Neighborhood Hits	756
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA5_MOUSE
θ value	2.97466e-19 (rank : 133)	NC score	0.908504 (rank : 91)
Query Neighborhood Hits	1243	Target Neighborhood Hits	950	Shared Neighborhood Hits	761
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FAK2_HUMAN
θ value	2.97466e-19 (rank : 134)	NC score	0.925915 (rank : 19)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	746
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

M3K12_HUMAN
θ value	2.97466e-19 (rank : 135)	NC score	0.890571 (rank : 139)
Query Neighborhood Hits	1243	Target Neighborhood Hits	940	Shared Neighborhood Hits	784
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	2.97466e-19 (rank : 136)	NC score	0.890734 (rank : 137)
Query Neighborhood Hits	1243	Target Neighborhood Hits	957	Shared Neighborhood Hits	787
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

JAK1_HUMAN
θ value	3.88503e-19 (rank : 137)	NC score	0.909679 (rank : 85)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	757
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

VGFR3_MOUSE
θ value	5.07402e-19 (rank : 138)	NC score	0.872555 (rank : 172)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1056	Shared Neighborhood Hits	741
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FAK2_MOUSE
θ value	6.62687e-19 (rank : 139)	NC score	0.925447 (rank : 20)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	745
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TYK2_MOUSE
θ value	6.62687e-19 (rank : 140)	NC score	0.912965 (rank : 65)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	766
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

PGFRB_MOUSE
θ value	8.65492e-19 (rank : 141)	NC score	0.883037 (rank : 158)
Query Neighborhood Hits	1243	Target Neighborhood Hits	960	Shared Neighborhood Hits	739
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

CSF1R_HUMAN
θ value	1.13037e-18 (rank : 142)	NC score	0.888579 (rank : 143)
Query Neighborhood Hits	1243	Target Neighborhood Hits	943	Shared Neighborhood Hits	737
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHA8_MOUSE
θ value	1.47631e-18 (rank : 143)	NC score	0.888308 (rank : 148)
Query Neighborhood Hits	1243	Target Neighborhood Hits	969	Shared Neighborhood Hits	754
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

VGFR2_MOUSE
θ value	1.47631e-18 (rank : 144)	NC score	0.856639 (rank : 187)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1089	Shared Neighborhood Hits	745
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EPHA4_HUMAN
θ value	1.92812e-18 (rank : 145)	NC score	0.890836 (rank : 136)
Query Neighborhood Hits	1243	Target Neighborhood Hits	975	Shared Neighborhood Hits	760
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	1.92812e-18 (rank : 146)	NC score	0.890600 (rank : 138)
Query Neighborhood Hits	1243	Target Neighborhood Hits	982	Shared Neighborhood Hits	760
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

VGFR3_HUMAN
θ value	1.92812e-18 (rank : 147)	NC score	0.874423 (rank : 171)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1037	Shared Neighborhood Hits	744
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

EPHA8_HUMAN
θ value	3.28887e-18 (rank : 148)	NC score	0.890998 (rank : 134)
Query Neighborhood Hits	1243	Target Neighborhood Hits	956	Shared Neighborhood Hits	756
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

M3K13_HUMAN
θ value	5.60996e-18 (rank : 149)	NC score	0.887046 (rank : 149)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	766
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K11_HUMAN
θ value	1.24977e-17 (rank : 150)	NC score	0.884080 (rank : 154)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1136	Shared Neighborhood Hits	806
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ERBB2_MOUSE
θ value	1.63225e-17 (rank : 151)	NC score	0.909816 (rank : 83)
Query Neighborhood Hits	1243	Target Neighborhood Hits	918	Shared Neighborhood Hits	761
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

JAK2_MOUSE
θ value	2.7842e-17 (rank : 152)	NC score	0.907883 (rank : 95)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	758
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

VGFR1_HUMAN
θ value	2.7842e-17 (rank : 153)	NC score	0.850392 (rank : 193)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1109	Shared Neighborhood Hits	750
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ERBB2_HUMAN
θ value	3.63628e-17 (rank : 154)	NC score	0.908826 (rank : 88)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1073	Shared Neighborhood Hits	820
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

JAK2_HUMAN
θ value	3.63628e-17 (rank : 155)	NC score	0.907079 (rank : 98)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	759
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

PGFRA_HUMAN
θ value	6.20254e-17 (rank : 156)	NC score	0.883302 (rank : 156)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	741
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	6.20254e-17 (rank : 157)	NC score	0.883502 (rank : 155)
Query Neighborhood Hits	1243	Target Neighborhood Hits	975	Shared Neighborhood Hits	740
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

JAK3_HUMAN
θ value	1.80466e-16 (rank : 158)	NC score	0.908155 (rank : 92)
Query Neighborhood Hits	1243	Target Neighborhood Hits	827	Shared Neighborhood Hits	756
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

KIT_HUMAN
θ value	1.80466e-16 (rank : 159)	NC score	0.890293 (rank : 140)
Query Neighborhood Hits	1243	Target Neighborhood Hits	953	Shared Neighborhood Hits	744
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

M3K10_HUMAN
θ value	5.25075e-16 (rank : 160)	NC score	0.879425 (rank : 165)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1071	Shared Neighborhood Hits	763
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

KIT_MOUSE
θ value	6.85773e-16 (rank : 161)	NC score	0.885436 (rank : 152)
Query Neighborhood Hits	1243	Target Neighborhood Hits	949	Shared Neighborhood Hits	742
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

M3KL4_HUMAN
θ value	1.16975e-15 (rank : 162)	NC score	0.881427 (rank : 162)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1087	Shared Neighborhood Hits	765
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

JAK3_MOUSE
θ value	1.52774e-15 (rank : 163)	NC score	0.899881 (rank : 115)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	750
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

TNK1_HUMAN
θ value	1.99529e-15 (rank : 164)	NC score	0.921739 (rank : 28)
Query Neighborhood Hits	1243	Target Neighborhood Hits	815	Shared Neighborhood Hits	741
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

EPHAA_HUMAN
θ value	2.60593e-15 (rank : 165)	NC score	0.866267 (rank : 178)
Query Neighborhood Hits	1243	Target Neighborhood Hits	960	Shared Neighborhood Hits	709
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

NUAK2_HUMAN
θ value	4.44505e-15 (rank : 166)	NC score	0.770134 (rank : 268)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	764
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

BRAF1_HUMAN
θ value	5.8054e-15 (rank : 167)	NC score	0.886607 (rank : 150)
Query Neighborhood Hits	1243	Target Neighborhood Hits	883	Shared Neighborhood Hits	758
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

FLT3_MOUSE
θ value	7.58209e-15 (rank : 168)	NC score	0.893658 (rank : 126)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	734
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FLT3_HUMAN
θ value	1.29331e-14 (rank : 169)	NC score	0.897047 (rank : 121)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	734
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

ARAF_HUMAN
θ value	1.68911e-14 (rank : 170)	NC score	0.883123 (rank : 157)
Query Neighborhood Hits	1243	Target Neighborhood Hits	924	Shared Neighborhood Hits	768
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

EPHB6_HUMAN
θ value	2.88119e-14 (rank : 171)	NC score	0.836719 (rank : 201)
Query Neighborhood Hits	1243	Target Neighborhood Hits	912	Shared Neighborhood Hits	659
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ARAF_MOUSE
θ value	4.91457e-14 (rank : 172)	NC score	0.884968 (rank : 153)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	758
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

EPHA6_HUMAN
θ value	4.91457e-14 (rank : 173)	NC score	0.878702 (rank : 167)
Query Neighborhood Hits	1243	Target Neighborhood Hits	959	Shared Neighborhood Hits	754
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

RIPK1_HUMAN
θ value	6.41864e-14 (rank : 174)	NC score	0.878030 (rank : 169)
Query Neighborhood Hits	1243	Target Neighborhood Hits	891	Shared Neighborhood Hits	765
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

EPHA6_MOUSE
θ value	1.42992e-13 (rank : 175)	NC score	0.879191 (rank : 166)
Query Neighborhood Hits	1243	Target Neighborhood Hits	946	Shared Neighborhood Hits	750
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

TNK1_MOUSE
θ value	1.42992e-13 (rank : 176)	NC score	0.918309 (rank : 47)
Query Neighborhood Hits	1243	Target Neighborhood Hits	806	Shared Neighborhood Hits	736
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

HUNK_MOUSE
θ value	2.43908e-13 (rank : 177)	NC score	0.752432 (rank : 349)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	764
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

YSK4_HUMAN
θ value	2.43908e-13 (rank : 178)	NC score	0.813854 (rank : 209)
Query Neighborhood Hits	1243	Target Neighborhood Hits	921	Shared Neighborhood Hits	761
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

IRAK4_MOUSE
θ value	3.18553e-13 (rank : 179)	NC score	0.862492 (rank : 180)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	750
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

M3K9_HUMAN
θ value	4.16044e-13 (rank : 180)	NC score	0.878273 (rank : 168)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1123	Shared Neighborhood Hits	789
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

PKN2_HUMAN
θ value	5.43371e-13 (rank : 181)	NC score	0.743367 (rank : 390)
Query Neighborhood Hits	1243	Target Neighborhood Hits	892	Shared Neighborhood Hits	753
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	5.43371e-13 (rank : 182)	NC score	0.742382 (rank : 395)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	752
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

EPHB6_MOUSE
θ value	7.09661e-13 (rank : 183)	NC score	0.843509 (rank : 198)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	678
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

HUNK_HUMAN
θ value	7.09661e-13 (rank : 184)	NC score	0.752610 (rank : 346)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	764
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

NEK6_HUMAN
θ value	7.09661e-13 (rank : 185)	NC score	0.798496 (rank : 222)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	760
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

RAF1_MOUSE
θ value	7.09661e-13 (rank : 186)	NC score	0.881821 (rank : 161)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	758
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

IRAK4_HUMAN
θ value	9.26847e-13 (rank : 187)	NC score	0.866564 (rank : 177)
Query Neighborhood Hits	1243	Target Neighborhood Hits	816	Shared Neighborhood Hits	748
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

NEK6_MOUSE
θ value	9.26847e-13 (rank : 188)	NC score	0.798768 (rank : 221)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	760
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

RAF1_HUMAN
θ value	9.26847e-13 (rank : 189)	NC score	0.880745 (rank : 163)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	756
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

NUAK2_MOUSE
θ value	1.2105e-12 (rank : 190)	NC score	0.762946 (rank : 288)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	763
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PLK4_HUMAN
θ value	2.0648e-12 (rank : 191)	NC score	0.758435 (rank : 309)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	757
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	2.0648e-12 (rank : 192)	NC score	0.760425 (rank : 300)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	758
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PKN1_MOUSE
θ value	2.69671e-12 (rank : 193)	NC score	0.747163 (rank : 375)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	756
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

NEK1_HUMAN
θ value	3.52202e-12 (rank : 194)	NC score	0.782618 (rank : 241)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1129	Shared Neighborhood Hits	772
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

M3K3_HUMAN
θ value	6.00763e-12 (rank : 195)	NC score	0.774783 (rank : 257)
Query Neighborhood Hits	1243	Target Neighborhood Hits	885	Shared Neighborhood Hits	761
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

PKN1_HUMAN
θ value	6.00763e-12 (rank : 196)	NC score	0.747407 (rank : 369)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	762
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

RIPK1_MOUSE
θ value	6.00763e-12 (rank : 197)	NC score	0.876883 (rank : 170)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	762
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

NEK7_MOUSE
θ value	1.02475e-11 (rank : 198)	NC score	0.803944 (rank : 216)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	760
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NIM1_HUMAN
θ value	1.02475e-11 (rank : 199)	NC score	0.753082 (rank : 344)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	757
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

LIMK2_HUMAN
θ value	1.33837e-11 (rank : 200)	NC score	0.844246 (rank : 196)
Query Neighborhood Hits	1243	Target Neighborhood Hits	986	Shared Neighborhood Hits	760
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

M3K6_HUMAN
θ value	1.33837e-11 (rank : 201)	NC score	0.771763 (rank : 264)
Query Neighborhood Hits	1243	Target Neighborhood Hits	889	Shared Neighborhood Hits	766
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

NEK1_MOUSE
θ value	1.33837e-11 (rank : 202)	NC score	0.782372 (rank : 242)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1311	Shared Neighborhood Hits	790
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK7_HUMAN
θ value	1.33837e-11 (rank : 203)	NC score	0.804163 (rank : 215)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	760
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

OXSR1_MOUSE
θ value	1.33837e-11 (rank : 204)	NC score	0.797179 (rank : 224)
Query Neighborhood Hits	1243	Target Neighborhood Hits	865	Shared Neighborhood Hits	760
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

TAOK2_MOUSE
θ value	1.33837e-11 (rank : 205)	NC score	0.766151 (rank : 281)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1373	Shared Neighborhood Hits	786
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TESK2_HUMAN
θ value	1.33837e-11 (rank : 206)	NC score	0.866634 (rank : 176)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	758
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

OXSR1_HUMAN
θ value	1.74796e-11 (rank : 207)	NC score	0.796895 (rank : 227)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	766
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

TAOK2_HUMAN
θ value	1.74796e-11 (rank : 208)	NC score	0.778669 (rank : 250)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1172	Shared Neighborhood Hits	777
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK3_HUMAN
θ value	1.74796e-11 (rank : 209)	NC score	0.746485 (rank : 385)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1494	Shared Neighborhood Hits	781
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

NEK4_MOUSE
θ value	2.28291e-11 (rank : 210)	NC score	0.797449 (rank : 223)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	762
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK9_HUMAN
θ value	2.28291e-11 (rank : 211)	NC score	0.768801 (rank : 272)
Query Neighborhood Hits	1243	Target Neighborhood Hits	900	Shared Neighborhood Hits	761
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NIM1_MOUSE
θ value	2.28291e-11 (rank : 212)	NC score	0.747380 (rank : 370)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	755
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TAOK1_HUMAN
θ value	2.28291e-11 (rank : 213)	NC score	0.736119 (rank : 419)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1734	Shared Neighborhood Hits	796
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	2.28291e-11 (rank : 214)	NC score	0.735730 (rank : 420)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1720	Shared Neighborhood Hits	793
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

M3K3_MOUSE
θ value	2.98157e-11 (rank : 215)	NC score	0.772872 (rank : 260)
Query Neighborhood Hits	1243	Target Neighborhood Hits	876	Shared Neighborhood Hits	759
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK4_HUMAN
θ value	2.98157e-11 (rank : 216)	NC score	0.796137 (rank : 228)
Query Neighborhood Hits	1243	Target Neighborhood Hits	883	Shared Neighborhood Hits	759
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

STK6_MOUSE
θ value	2.98157e-11 (rank : 217)	NC score	0.753679 (rank : 342)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	769
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

ULK1_MOUSE
θ value	2.98157e-11 (rank : 218)	NC score	0.780825 (rank : 243)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1214	Shared Neighborhood Hits	906
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

M3K5_HUMAN
θ value	3.89403e-11 (rank : 219)	NC score	0.772070 (rank : 262)
Query Neighborhood Hits	1243	Target Neighborhood Hits	868	Shared Neighborhood Hits	760
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	3.89403e-11 (rank : 220)	NC score	0.772431 (rank : 261)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	760
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MLTK_MOUSE
θ value	3.89403e-11 (rank : 221)	NC score	0.888893 (rank : 142)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	754
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

NEK2_HUMAN
θ value	3.89403e-11 (rank : 222)	NC score	0.778994 (rank : 249)
Query Neighborhood Hits	1243	Target Neighborhood Hits	908	Shared Neighborhood Hits	754
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

TESK2_MOUSE
θ value	3.89403e-11 (rank : 223)	NC score	0.866819 (rank : 175)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	751
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

KPCA_MOUSE
θ value	5.08577e-11 (rank : 224)	NC score	0.715455 (rank : 502)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1067	Shared Neighborhood Hits	757
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PKN3_HUMAN
θ value	5.08577e-11 (rank : 225)	NC score	0.724423 (rank : 469)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	763
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	5.08577e-11 (rank : 226)	NC score	0.732859 (rank : 438)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	797
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

LIMK2_MOUSE
θ value	6.64225e-11 (rank : 227)	NC score	0.841313 (rank : 200)
Query Neighborhood Hits	1243	Target Neighborhood Hits	998	Shared Neighborhood Hits	759
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MLTK_HUMAN
θ value	6.64225e-11 (rank : 228)	NC score	0.888537 (rank : 145)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	761
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ULK1_HUMAN
θ value	6.64225e-11 (rank : 229)	NC score	0.779889 (rank : 246)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1121	Shared Neighborhood Hits	868
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ANPRA_MOUSE
θ value	8.67504e-11 (rank : 230)	NC score	0.690336 (rank : 623)
Query Neighborhood Hits	1243	Target Neighborhood Hits	600	Shared Neighborhood Hits	523
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

KSR2_HUMAN
θ value	8.67504e-11 (rank : 231)	NC score	0.855071 (rank : 189)
Query Neighborhood Hits	1243	Target Neighborhood Hits	920	Shared Neighborhood Hits	782
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

M3K15_HUMAN
θ value	8.67504e-11 (rank : 232)	NC score	0.779170 (rank : 247)
Query Neighborhood Hits	1243	Target Neighborhood Hits	914	Shared Neighborhood Hits	762
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

MARK4_HUMAN
θ value	8.67504e-11 (rank : 233)	NC score	0.757878 (rank : 314)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	770
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	8.67504e-11 (rank : 234)	NC score	0.757753 (rank : 315)
Query Neighborhood Hits	1243	Target Neighborhood Hits	898	Shared Neighborhood Hits	769
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

TAOK3_MOUSE
θ value	8.67504e-11 (rank : 235)	NC score	0.746539 (rank : 384)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1458	Shared Neighborhood Hits	776
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

KPCA_HUMAN
θ value	1.133e-10 (rank : 236)	NC score	0.711051 (rank : 516)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1070	Shared Neighborhood Hits	759
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MARK2_HUMAN
θ value	1.133e-10 (rank : 237)	NC score	0.757409 (rank : 322)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1056	Shared Neighborhood Hits	808
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

KPCE_MOUSE
θ value	1.47974e-10 (rank : 238)	NC score	0.705775 (rank : 545)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	752
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KS6A3_MOUSE
θ value	1.47974e-10 (rank : 239)	NC score	0.737617 (rank : 406)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	762
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

NEK3_HUMAN
θ value	1.47974e-10 (rank : 240)	NC score	0.788167 (rank : 234)
Query Neighborhood Hits	1243	Target Neighborhood Hits	865	Shared Neighborhood Hits	758
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

SLK_HUMAN
θ value	1.47974e-10 (rank : 241)	NC score	0.742854 (rank : 394)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1775	Shared Neighborhood Hits	796
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK3_HUMAN
θ value	1.47974e-10 (rank : 242)	NC score	0.788380 (rank : 233)
Query Neighborhood Hits	1243	Target Neighborhood Hits	861	Shared Neighborhood Hits	758
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

AAPK2_HUMAN
θ value	1.9326e-10 (rank : 243)	NC score	0.754551 (rank : 335)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	752
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

MARK2_MOUSE
θ value	1.9326e-10 (rank : 244)	NC score	0.754043 (rank : 337)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1018	Shared Neighborhood Hits	795
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

NUAK1_HUMAN
θ value	1.9326e-10 (rank : 245)	NC score	0.764326 (rank : 284)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	765
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

ULK2_HUMAN
θ value	1.9326e-10 (rank : 246)	NC score	0.775772 (rank : 256)
Query Neighborhood Hits	1243	Target Neighborhood Hits	979	Shared Neighborhood Hits	794
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

BMPR2_HUMAN
θ value	2.52405e-10 (rank : 247)	NC score	0.753783 (rank : 341)
Query Neighborhood Hits	1243	Target Neighborhood Hits	736	Shared Neighborhood Hits	679
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

NUAK1_MOUSE
θ value	2.52405e-10 (rank : 248)	NC score	0.762582 (rank : 289)
Query Neighborhood Hits	1243	Target Neighborhood Hits	881	Shared Neighborhood Hits	766
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

STK3_MOUSE
θ value	2.52405e-10 (rank : 249)	NC score	0.789236 (rank : 232)
Query Neighborhood Hits	1243	Target Neighborhood Hits	869	Shared Neighborhood Hits	757
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

WNK4_MOUSE
θ value	2.52405e-10 (rank : 250)	NC score	0.719384 (rank : 487)
Query Neighborhood Hits	1243	Target Neighborhood Hits	961	Shared Neighborhood Hits	744
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

NEK9_MOUSE
θ value	3.29651e-10 (rank : 251)	NC score	0.766489 (rank : 278)
Query Neighborhood Hits	1243	Target Neighborhood Hits	890	Shared Neighborhood Hits	758
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

STK4_MOUSE
θ value	3.29651e-10 (rank : 252)	NC score	0.791177 (rank : 230)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	761
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

ULK2_MOUSE
θ value	3.29651e-10 (rank : 253)	NC score	0.776880 (rank : 253)
Query Neighborhood Hits	1243	Target Neighborhood Hits	943	Shared Neighborhood Hits	785
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

WNK4_HUMAN
θ value	3.29651e-10 (rank : 254)	NC score	0.717038 (rank : 499)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1043	Shared Neighborhood Hits	760
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

LIMK1_HUMAN
θ value	4.30538e-10 (rank : 255)	NC score	0.835484 (rank : 202)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1005	Shared Neighborhood Hits	756
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

SLK_MOUSE
θ value	4.30538e-10 (rank : 256)	NC score	0.743873 (rank : 388)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1798	Shared Neighborhood Hits	797
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

STK35_HUMAN
θ value	4.30538e-10 (rank : 257)	NC score	0.760884 (rank : 296)
Query Neighborhood Hits	1243	Target Neighborhood Hits	825	Shared Neighborhood Hits	748
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK4_HUMAN
θ value	4.30538e-10 (rank : 258)	NC score	0.790844 (rank : 231)
Query Neighborhood Hits	1243	Target Neighborhood Hits	870	Shared Neighborhood Hits	760
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

KS6A3_HUMAN
θ value	5.62301e-10 (rank : 259)	NC score	0.737371 (rank : 408)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	762
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PLK1_MOUSE
θ value	5.62301e-10 (rank : 260)	NC score	0.745105 (rank : 387)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

RIPK4_HUMAN
θ value	5.62301e-10 (rank : 261)	NC score	0.690152 (rank : 624)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1094	Shared Neighborhood Hits	744
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

STK39_HUMAN
θ value	5.62301e-10 (rank : 262)	NC score	0.797134 (rank : 225)
Query Neighborhood Hits	1243	Target Neighborhood Hits	882	Shared Neighborhood Hits	765
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	5.62301e-10 (rank : 263)	NC score	0.797131 (rank : 226)
Query Neighborhood Hits	1243	Target Neighborhood Hits	915	Shared Neighborhood Hits	772
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

ACVL1_MOUSE
θ value	7.34386e-10 (rank : 264)	NC score	0.791508 (rank : 229)
Query Neighborhood Hits	1243	Target Neighborhood Hits	739	Shared Neighborhood Hits	708
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

BMR1A_MOUSE
θ value	7.34386e-10 (rank : 265)	NC score	0.779100 (rank : 248)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	715
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

MARK3_MOUSE
θ value	7.34386e-10 (rank : 266)	NC score	0.758165 (rank : 311)
Query Neighborhood Hits	1243	Target Neighborhood Hits	919	Shared Neighborhood Hits	773
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

STK36_HUMAN
θ value	7.34386e-10 (rank : 267)	NC score	0.766231 (rank : 280)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	765
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

AURKB_MOUSE
θ value	9.59137e-10 (rank : 268)	NC score	0.748770 (rank : 363)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	763
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

CDK9_MOUSE
θ value	9.59137e-10 (rank : 269)	NC score	0.731280 (rank : 444)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	746
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

IRAK1_HUMAN
θ value	9.59137e-10 (rank : 270)	NC score	0.822322 (rank : 208)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	725
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

KPCE_HUMAN
θ value	9.59137e-10 (rank : 271)	NC score	0.704965 (rank : 554)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	752
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

LIMK1_MOUSE
θ value	9.59137e-10 (rank : 272)	NC score	0.835416 (rank : 203)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1008	Shared Neighborhood Hits	758
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

NEK3_MOUSE
θ value	9.59137e-10 (rank : 273)	NC score	0.782625 (rank : 240)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	758
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

AAPK1_HUMAN
θ value	1.25267e-09 (rank : 274)	NC score	0.761473 (rank : 292)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	752
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	1.25267e-09 (rank : 275)	NC score	0.760880 (rank : 297)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	752
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

ANPRA_HUMAN
θ value	1.25267e-09 (rank : 276)	NC score	0.691821 (rank : 613)
Query Neighborhood Hits	1243	Target Neighborhood Hits	612	Shared Neighborhood Hits	527
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

CDK9_HUMAN
θ value	1.25267e-09 (rank : 277)	NC score	0.731302 (rank : 443)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	746
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

KPCT_MOUSE
θ value	1.25267e-09 (rank : 278)	NC score	0.733638 (rank : 434)
Query Neighborhood Hits	1243	Target Neighborhood Hits	895	Shared Neighborhood Hits	757
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

M4K2_MOUSE
θ value	1.25267e-09 (rank : 279)	NC score	0.751179 (rank : 356)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	756
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

PLK1_HUMAN
θ value	1.25267e-09 (rank : 280)	NC score	0.754306 (rank : 336)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KPCT_HUMAN
θ value	1.63604e-09 (rank : 281)	NC score	0.737093 (rank : 411)
Query Neighborhood Hits	1243	Target Neighborhood Hits	897	Shared Neighborhood Hits	758
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

NEK8_HUMAN
θ value	1.63604e-09 (rank : 282)	NC score	0.767341 (rank : 274)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	756
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

BMR1A_HUMAN
θ value	2.13673e-09 (rank : 283)	NC score	0.780040 (rank : 245)
Query Neighborhood Hits	1243	Target Neighborhood Hits	759	Shared Neighborhood Hits	716
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

CHK1_MOUSE
θ value	2.13673e-09 (rank : 284)	NC score	0.751809 (rank : 351)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	756
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

M4K2_HUMAN
θ value	2.13673e-09 (rank : 285)	NC score	0.749035 (rank : 360)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	758
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

STK36_MOUSE
θ value	2.13673e-09 (rank : 286)	NC score	0.770585 (rank : 265)
Query Neighborhood Hits	1243	Target Neighborhood Hits	877	Shared Neighborhood Hits	762
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK6_HUMAN
θ value	2.13673e-09 (rank : 287)	NC score	0.757500 (rank : 320)
Query Neighborhood Hits	1243	Target Neighborhood Hits	916	Shared Neighborhood Hits	770
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

ACV1B_HUMAN
θ value	2.79066e-09 (rank : 288)	NC score	0.742875 (rank : 393)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	713
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	2.79066e-09 (rank : 289)	NC score	0.743226 (rank : 391)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	713
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

BMPR2_MOUSE
θ value	2.79066e-09 (rank : 290)	NC score	0.746956 (rank : 378)
Query Neighborhood Hits	1243	Target Neighborhood Hits	738	Shared Neighborhood Hits	679
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

NEK8_MOUSE
θ value	2.79066e-09 (rank : 291)	NC score	0.766253 (rank : 279)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	755
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

PRKX_MOUSE
θ value	2.79066e-09 (rank : 292)	NC score	0.722275 (rank : 476)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	759
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

STK33_HUMAN
θ value	2.79066e-09 (rank : 293)	NC score	0.762572 (rank : 290)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	758
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

KSR1_MOUSE
θ value	3.64472e-09 (rank : 294)	NC score	0.860199 (rank : 183)
Query Neighborhood Hits	1243	Target Neighborhood Hits	870	Shared Neighborhood Hits	752
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

ACV1C_MOUSE
θ value	4.76016e-09 (rank : 295)	NC score	0.731049 (rank : 445)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	673
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

AKT3_HUMAN
θ value	4.76016e-09 (rank : 296)	NC score	0.707872 (rank : 539)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	758
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	4.76016e-09 (rank : 297)	NC score	0.707842 (rank : 540)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	758
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

PLK2_MOUSE
θ value	4.76016e-09 (rank : 298)	NC score	0.758593 (rank : 307)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

TGFR1_HUMAN
θ value	4.76016e-09 (rank : 299)	NC score	0.760566 (rank : 299)
Query Neighborhood Hits	1243	Target Neighborhood Hits	755	Shared Neighborhood Hits	712
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	4.76016e-09 (rank : 300)	NC score	0.760804 (rank : 298)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	712
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

CHK1_HUMAN
θ value	6.21693e-09 (rank : 301)	NC score	0.753095 (rank : 343)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	754
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

GUC2F_HUMAN
θ value	6.21693e-09 (rank : 302)	NC score	0.757697 (rank : 316)
Query Neighborhood Hits	1243	Target Neighborhood Hits	740	Shared Neighborhood Hits	652
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

KPCD_HUMAN
θ value	6.21693e-09 (rank : 303)	NC score	0.733690 (rank : 433)
Query Neighborhood Hits	1243	Target Neighborhood Hits	900	Shared Neighborhood Hits	759
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCZ_HUMAN
θ value	6.21693e-09 (rank : 304)	NC score	0.675873 (rank : 672)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	755
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	6.21693e-09 (rank : 305)	NC score	0.675940 (rank : 671)
Query Neighborhood Hits	1243	Target Neighborhood Hits	882	Shared Neighborhood Hits	754
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KS6A2_MOUSE
θ value	6.21693e-09 (rank : 306)	NC score	0.736320 (rank : 416)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	762
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

M3K2_HUMAN
θ value	6.21693e-09 (rank : 307)	NC score	0.766868 (rank : 277)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	757
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	6.21693e-09 (rank : 308)	NC score	0.758416 (rank : 310)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	754
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MARK1_MOUSE
θ value	6.21693e-09 (rank : 309)	NC score	0.756179 (rank : 331)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	768
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

NEK2_MOUSE
θ value	6.21693e-09 (rank : 310)	NC score	0.770087 (rank : 269)
Query Neighborhood Hits	1243	Target Neighborhood Hits	876	Shared Neighborhood Hits	753
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

TGFR2_HUMAN
θ value	6.21693e-09 (rank : 311)	NC score	0.752486 (rank : 347)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	701
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

IRAK1_MOUSE
θ value	8.11959e-09 (rank : 312)	NC score	0.823281 (rank : 207)
Query Neighborhood Hits	1243	Target Neighborhood Hits	784	Shared Neighborhood Hits	706
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

PLK3_HUMAN
θ value	8.11959e-09 (rank : 313)	NC score	0.751445 (rank : 353)
Query Neighborhood Hits	1243	Target Neighborhood Hits	865	Shared Neighborhood Hits	760
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	8.11959e-09 (rank : 314)	NC score	0.752437 (rank : 348)
Query Neighborhood Hits	1243	Target Neighborhood Hits	863	Shared Neighborhood Hits	761
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

AURKC_MOUSE
θ value	1.06045e-08 (rank : 315)	NC score	0.757881 (rank : 313)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	759
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

KS6A2_HUMAN
θ value	1.06045e-08 (rank : 316)	NC score	0.737587 (rank : 407)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	761
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MYO3A_HUMAN
θ value	1.06045e-08 (rank : 317)	NC score	0.661244 (rank : 699)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1033	Shared Neighborhood Hits	760
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

ST32A_HUMAN
θ value	1.06045e-08 (rank : 318)	NC score	0.719111 (rank : 489)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	750
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

KSR1_HUMAN
θ value	1.38499e-08 (rank : 319)	NC score	0.857448 (rank : 185)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	746
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

TGFR2_MOUSE
θ value	1.38499e-08 (rank : 320)	NC score	0.751224 (rank : 355)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	701
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

CDKL2_HUMAN
θ value	1.80886e-08 (rank : 321)	NC score	0.735074 (rank : 426)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

KPCI_HUMAN
θ value	1.80886e-08 (rank : 322)	NC score	0.686433 (rank : 634)
Query Neighborhood Hits	1243	Target Neighborhood Hits	885	Shared Neighborhood Hits	756
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	1.80886e-08 (rank : 323)	NC score	0.685890 (rank : 636)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	756
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MARK3_HUMAN
θ value	1.80886e-08 (rank : 324)	NC score	0.756791 (rank : 325)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	769
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

ANPRB_HUMAN
θ value	2.36244e-08 (rank : 325)	NC score	0.691835 (rank : 611)
Query Neighborhood Hits	1243	Target Neighborhood Hits	646	Shared Neighborhood Hits	561
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

KS6A1_HUMAN
θ value	2.36244e-08 (rank : 326)	NC score	0.737215 (rank : 410)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	759
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MYO3A_MOUSE
θ value	2.36244e-08 (rank : 327)	NC score	0.663875 (rank : 695)
Query Neighborhood Hits	1243	Target Neighborhood Hits	902	Shared Neighborhood Hits	752
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

NRK_MOUSE
θ value	2.36244e-08 (rank : 328)	NC score	0.754919 (rank : 333)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	757
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PHKG1_HUMAN
θ value	2.36244e-08 (rank : 329)	NC score	0.683538 (rank : 642)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	754
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

KPCL_MOUSE
θ value	3.08544e-08 (rank : 330)	NC score	0.696693 (rank : 590)
Query Neighborhood Hits	1243	Target Neighborhood Hits	891	Shared Neighborhood Hits	753
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MARK1_HUMAN
θ value	3.08544e-08 (rank : 331)	NC score	0.756250 (rank : 329)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	764
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

PAK4_MOUSE
θ value	3.08544e-08 (rank : 332)	NC score	0.761465 (rank : 293)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1098	Shared Neighborhood Hits	844
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PLK2_HUMAN
θ value	3.08544e-08 (rank : 333)	NC score	0.758080 (rank : 312)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	757
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ULK3_MOUSE
θ value	3.08544e-08 (rank : 334)	NC score	0.765517 (rank : 283)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	758
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ACVL1_HUMAN
θ value	4.0297e-08 (rank : 335)	NC score	0.776062 (rank : 254)
Query Neighborhood Hits	1243	Target Neighborhood Hits	716	Shared Neighborhood Hits	682
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	4.0297e-08 (rank : 336)	NC score	0.767012 (rank : 276)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	717
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	4.0297e-08 (rank : 337)	NC score	0.770525 (rank : 266)
Query Neighborhood Hits	1243	Target Neighborhood Hits	768	Shared Neighborhood Hits	721
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

DCAK1_MOUSE
θ value	4.0297e-08 (rank : 338)	NC score	0.705237 (rank : 551)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	752
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

M3K4_HUMAN
θ value	4.0297e-08 (rank : 339)	NC score	0.761835 (rank : 291)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	770
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K7_HUMAN
θ value	4.0297e-08 (rank : 340)	NC score	0.868458 (rank : 174)
Query Neighborhood Hits	1243	Target Neighborhood Hits	892	Shared Neighborhood Hits	758
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	4.0297e-08 (rank : 341)	NC score	0.868566 (rank : 173)
Query Neighborhood Hits	1243	Target Neighborhood Hits	892	Shared Neighborhood Hits	758
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MELK_MOUSE
θ value	4.0297e-08 (rank : 342)	NC score	0.739849 (rank : 401)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	758
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

PAK4_HUMAN
θ value	4.0297e-08 (rank : 343)	NC score	0.759901 (rank : 302)
Query Neighborhood Hits	1243	Target Neighborhood Hits	924	Shared Neighborhood Hits	782
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK7_HUMAN
θ value	4.0297e-08 (rank : 344)	NC score	0.767128 (rank : 275)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	765
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

CCRK_HUMAN
θ value	5.26297e-08 (rank : 345)	NC score	0.708282 (rank : 534)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	752
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CDKL2_MOUSE
θ value	5.26297e-08 (rank : 346)	NC score	0.734381 (rank : 431)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	750
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

DCAK1_HUMAN
θ value	5.26297e-08 (rank : 347)	NC score	0.705712 (rank : 546)
Query Neighborhood Hits	1243	Target Neighborhood Hits	877	Shared Neighborhood Hits	756
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

IKKA_HUMAN
θ value	5.26297e-08 (rank : 348)	NC score	0.787090 (rank : 235)
Query Neighborhood Hits	1243	Target Neighborhood Hits	863	Shared Neighborhood Hits	752
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KS6A5_HUMAN
θ value	5.26297e-08 (rank : 349)	NC score	0.691311 (rank : 617)
Query Neighborhood Hits	1243	Target Neighborhood Hits	855	Shared Neighborhood Hits	758
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

M4K3_HUMAN
θ value	5.26297e-08 (rank : 350)	NC score	0.757679 (rank : 317)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	759
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

KPCL_HUMAN
θ value	6.87365e-08 (rank : 351)	NC score	0.692820 (rank : 607)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	753
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KS6A5_MOUSE
θ value	6.87365e-08 (rank : 352)	NC score	0.689718 (rank : 629)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	758
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MAK_MOUSE
θ value	6.87365e-08 (rank : 353)	NC score	0.748927 (rank : 361)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	759
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

ST32A_MOUSE
θ value	6.87365e-08 (rank : 354)	NC score	0.726026 (rank : 463)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	750
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

TESK1_MOUSE
θ value	6.87365e-08 (rank : 355)	NC score	0.857197 (rank : 186)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	756
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

ACV1C_HUMAN
θ value	8.97725e-08 (rank : 356)	NC score	0.731356 (rank : 442)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	668
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CDKL1_MOUSE
θ value	8.97725e-08 (rank : 357)	NC score	0.705422 (rank : 549)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	746
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	8.97725e-08 (rank : 358)	NC score	0.730585 (rank : 447)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	749
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

ICK_MOUSE
θ value	8.97725e-08 (rank : 359)	NC score	0.748720 (rank : 364)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	756
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

KS6A6_HUMAN
θ value	8.97725e-08 (rank : 360)	NC score	0.729290 (rank : 448)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

PCTK2_HUMAN
θ value	8.97725e-08 (rank : 361)	NC score	0.726763 (rank : 458)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	8.97725e-08 (rank : 362)	NC score	0.727189 (rank : 455)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	748
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

RK_HUMAN
θ value	8.97725e-08 (rank : 363)	NC score	0.695068 (rank : 600)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	746
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ANPRB_MOUSE
θ value	1.17247e-07 (rank : 364)	NC score	0.670800 (rank : 681)
Query Neighborhood Hits	1243	Target Neighborhood Hits	607	Shared Neighborhood Hits	536
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

IKKB_MOUSE
θ value	1.17247e-07 (rank : 365)	NC score	0.774197 (rank : 258)
Query Neighborhood Hits	1243	Target Neighborhood Hits	984	Shared Neighborhood Hits	758
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MAK_HUMAN
θ value	1.17247e-07 (rank : 366)	NC score	0.746388 (rank : 386)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	755
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MINK1_HUMAN
θ value	1.17247e-07 (rank : 367)	NC score	0.757396 (rank : 323)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1477	Shared Neighborhood Hits	808
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	1.17247e-07 (rank : 368)	NC score	0.757024 (rank : 324)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1451	Shared Neighborhood Hits	799
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

TESK1_HUMAN
θ value	1.17247e-07 (rank : 369)	NC score	0.856255 (rank : 188)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	761
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TNIK_HUMAN
θ value	1.17247e-07 (rank : 370)	NC score	0.752043 (rank : 350)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1570	Shared Neighborhood Hits	808
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

AURKB_HUMAN
θ value	1.53129e-07 (rank : 371)	NC score	0.749657 (rank : 359)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	759
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

E2AK2_MOUSE
θ value	1.53129e-07 (rank : 372)	NC score	0.786843 (rank : 236)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	756
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

PAK7_MOUSE
θ value	1.53129e-07 (rank : 373)	NC score	0.765811 (rank : 282)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	765
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PCTK1_MOUSE
θ value	1.53129e-07 (rank : 374)	NC score	0.726457 (rank : 460)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	748
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

ICK_HUMAN
θ value	1.99992e-07 (rank : 375)	NC score	0.748466 (rank : 366)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	755
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

IKKB_HUMAN
θ value	1.99992e-07 (rank : 376)	NC score	0.777770 (rank : 252)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	760
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KPCB_HUMAN
θ value	1.99992e-07 (rank : 377)	NC score	0.706984 (rank : 542)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1121	Shared Neighborhood Hits	761
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	1.99992e-07 (rank : 378)	NC score	0.708482 (rank : 533)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1117	Shared Neighborhood Hits	761
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

M3K4_MOUSE
θ value	1.99992e-07 (rank : 379)	NC score	0.759635 (rank : 303)
Query Neighborhood Hits	1243	Target Neighborhood Hits	924	Shared Neighborhood Hits	770
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

MASTL_HUMAN
θ value	1.99992e-07 (rank : 380)	NC score	0.714863 (rank : 503)
Query Neighborhood Hits	1243	Target Neighborhood Hits	894	Shared Neighborhood Hits	757
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MELK_HUMAN
θ value	1.99992e-07 (rank : 381)	NC score	0.738161 (rank : 405)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	757
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

PAK6_HUMAN
θ value	1.99992e-07 (rank : 382)	NC score	0.768460 (rank : 273)
Query Neighborhood Hits	1243	Target Neighborhood Hits	915	Shared Neighborhood Hits	780
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PCTK1_HUMAN
θ value	1.99992e-07 (rank : 383)	NC score	0.724959 (rank : 468)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	750
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

RIPK3_HUMAN
θ value	1.99992e-07 (rank : 384)	NC score	0.853167 (rank : 192)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	750
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

STK10_HUMAN
θ value	1.99992e-07 (rank : 385)	NC score	0.729252 (rank : 449)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1921	Shared Neighborhood Hits	840
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DCAK2_MOUSE
θ value	2.61198e-07 (rank : 386)	NC score	0.699295 (rank : 580)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	750
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

IKKA_MOUSE
θ value	2.61198e-07 (rank : 387)	NC score	0.784654 (rank : 239)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	752
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MASTL_MOUSE
θ value	2.61198e-07 (rank : 388)	NC score	0.718879 (rank : 493)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	752
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

AKT1_HUMAN
θ value	3.41135e-07 (rank : 389)	NC score	0.697745 (rank : 589)
Query Neighborhood Hits	1243	Target Neighborhood Hits	885	Shared Neighborhood Hits	755
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

ANKK1_HUMAN
θ value	3.41135e-07 (rank : 390)	NC score	0.681569 (rank : 651)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1075	Shared Neighborhood Hits	736
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

BMR1B_MOUSE
θ value	3.41135e-07 (rank : 391)	NC score	0.780427 (rank : 244)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	706
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

K0999_MOUSE
θ value	3.41135e-07 (rank : 392)	NC score	0.742960 (rank : 392)
Query Neighborhood Hits	1243	Target Neighborhood Hits	931	Shared Neighborhood Hits	777
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KPCD_MOUSE
θ value	3.41135e-07 (rank : 393)	NC score	0.725101 (rank : 466)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	756
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

M4K4_MOUSE
θ value	3.41135e-07 (rank : 394)	NC score	0.752878 (rank : 345)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1560	Shared Neighborhood Hits	789
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MYLK2_HUMAN
θ value	3.41135e-07 (rank : 395)	NC score	0.746896 (rank : 379)
Query Neighborhood Hits	1243	Target Neighborhood Hits	920	Shared Neighborhood Hits	766
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYLK_MOUSE
θ value	3.41135e-07 (rank : 396)	NC score	0.675294 (rank : 674)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1489	Shared Neighborhood Hits	841
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

AKT2_HUMAN
θ value	4.45536e-07 (rank : 397)	NC score	0.705508 (rank : 548)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	757
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	4.45536e-07 (rank : 398)	NC score	0.705576 (rank : 547)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	757
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KPCG_HUMAN
θ value	4.45536e-07 (rank : 399)	NC score	0.689819 (rank : 627)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1126	Shared Neighborhood Hits	757
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6A1_MOUSE
θ value	4.45536e-07 (rank : 400)	NC score	0.718726 (rank : 494)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	756
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MST4_HUMAN
θ value	4.45536e-07 (rank : 401)	NC score	0.803526 (rank : 217)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	760
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	4.45536e-07 (rank : 402)	NC score	0.803250 (rank : 218)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	760
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

NRK_HUMAN
θ value	4.45536e-07 (rank : 403)	NC score	0.754753 (rank : 334)
Query Neighborhood Hits	1243	Target Neighborhood Hits	931	Shared Neighborhood Hits	756
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

PAK1_MOUSE
θ value	4.45536e-07 (rank : 404)	NC score	0.760171 (rank : 301)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	770
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PRKX_HUMAN
θ value	4.45536e-07 (rank : 405)	NC score	0.721442 (rank : 479)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	759
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

STK10_MOUSE
θ value	4.45536e-07 (rank : 406)	NC score	0.708212 (rank : 535)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2132	Shared Neighborhood Hits	837
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

BMR1B_HUMAN
θ value	5.81887e-07 (rank : 407)	NC score	0.778133 (rank : 251)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	705
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

CDKL1_HUMAN
θ value	5.81887e-07 (rank : 408)	NC score	0.709547 (rank : 523)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	749
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

M4K4_HUMAN
θ value	5.81887e-07 (rank : 409)	NC score	0.739432 (rank : 403)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1589	Shared Neighborhood Hits	783
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MK07_HUMAN
θ value	5.81887e-07 (rank : 410)	NC score	0.719102 (rank : 490)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1087	Shared Neighborhood Hits	818
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

PDK1L_HUMAN
θ value	5.81887e-07 (rank : 411)	NC score	0.746795 (rank : 380)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	744
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	5.81887e-07 (rank : 412)	NC score	0.747228 (rank : 373)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	744
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

STK24_HUMAN
θ value	5.81887e-07 (rank : 413)	NC score	0.807457 (rank : 213)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

AKT1_MOUSE
θ value	7.59969e-07 (rank : 414)	NC score	0.696529 (rank : 593)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	756
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CDC2_HUMAN
θ value	7.59969e-07 (rank : 415)	NC score	0.739646 (rank : 402)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	756
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK5_HUMAN
θ value	7.59969e-07 (rank : 416)	NC score	0.726141 (rank : 462)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	7.59969e-07 (rank : 417)	NC score	0.726432 (rank : 461)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

DAPK1_MOUSE
θ value	7.59969e-07 (rank : 418)	NC score	0.651135 (rank : 715)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1138	Shared Neighborhood Hits	751
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

K0999_HUMAN
θ value	7.59969e-07 (rank : 419)	NC score	0.742333 (rank : 396)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	764
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KPCG_MOUSE
θ value	7.59969e-07 (rank : 420)	NC score	0.690382 (rank : 622)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1123	Shared Neighborhood Hits	757
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPSH1_MOUSE
θ value	7.59969e-07 (rank : 421)	NC score	0.700843 (rank : 573)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	745
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MK07_MOUSE
θ value	7.59969e-07 (rank : 422)	NC score	0.719239 (rank : 488)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1054	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

PCTK3_HUMAN
θ value	7.59969e-07 (rank : 423)	NC score	0.720565 (rank : 482)
Query Neighborhood Hits	1243	Target Neighborhood Hits	827	Shared Neighborhood Hits	746
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PRKY_HUMAN
θ value	7.59969e-07 (rank : 424)	NC score	0.737352 (rank : 409)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	759
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

ST32B_MOUSE
θ value	7.59969e-07 (rank : 425)	NC score	0.711624 (rank : 512)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	746
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

STK24_MOUSE
θ value	7.59969e-07 (rank : 426)	NC score	0.807739 (rank : 212)
Query Neighborhood Hits	1243	Target Neighborhood Hits	856	Shared Neighborhood Hits	760
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

TSSK2_HUMAN
θ value	7.59969e-07 (rank : 427)	NC score	0.735038 (rank : 427)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	748
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

BMP2K_HUMAN
θ value	9.92553e-07 (rank : 428)	NC score	0.683450 (rank : 643)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	721
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CDKL4_HUMAN
θ value	9.92553e-07 (rank : 429)	NC score	0.720441 (rank : 483)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	745
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

DCAK3_MOUSE
θ value	9.92553e-07 (rank : 430)	NC score	0.710914 (rank : 518)
Query Neighborhood Hits	1243	Target Neighborhood Hits	922	Shared Neighborhood Hits	762
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

PAK2_HUMAN
θ value	9.92553e-07 (rank : 431)	NC score	0.760900 (rank : 295)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	766
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	9.92553e-07 (rank : 432)	NC score	0.761387 (rank : 294)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	764
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

SBK1_HUMAN
θ value	9.92553e-07 (rank : 433)	NC score	0.717192 (rank : 498)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	736
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

STK25_HUMAN
θ value	9.92553e-07 (rank : 434)	NC score	0.800518 (rank : 220)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	760
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

DCAK2_HUMAN
θ value	1.29631e-06 (rank : 435)	NC score	0.694875 (rank : 602)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	752
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

ILK2_HUMAN
θ value	1.29631e-06 (rank : 436)	NC score	0.661301 (rank : 698)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	561
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

KCC1G_MOUSE
θ value	1.29631e-06 (rank : 437)	NC score	0.713369 (rank : 507)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	756
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

M4K5_MOUSE
θ value	1.29631e-06 (rank : 438)	NC score	0.747140 (rank : 376)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	754
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MYLK_HUMAN
θ value	1.29631e-06 (rank : 439)	NC score	0.675477 (rank : 673)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1328	Shared Neighborhood Hits	770
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PHKG1_MOUSE
θ value	1.29631e-06 (rank : 440)	NC score	0.680880 (rank : 656)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	754
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_MOUSE
θ value	1.29631e-06 (rank : 441)	NC score	0.698867 (rank : 583)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	752
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

STK25_MOUSE
θ value	1.29631e-06 (rank : 442)	NC score	0.800917 (rank : 219)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	760
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

CDC2_MOUSE
θ value	1.69304e-06 (rank : 443)	NC score	0.736179 (rank : 418)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	754
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

DAPK1_HUMAN
θ value	1.69304e-06 (rank : 444)	NC score	0.653242 (rank : 711)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1130	Shared Neighborhood Hits	751
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KS6B2_HUMAN
θ value	1.69304e-06 (rank : 445)	NC score	0.708637 (rank : 531)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	765
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

NEK11_HUMAN
θ value	1.69304e-06 (rank : 446)	NC score	0.807317 (rank : 214)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1043	Shared Neighborhood Hits	770
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

RIPK2_MOUSE
θ value	1.69304e-06 (rank : 447)	NC score	0.849413 (rank : 194)
Query Neighborhood Hits	1243	Target Neighborhood Hits	776	Shared Neighborhood Hits	707
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

TSSK4_MOUSE
θ value	1.69304e-06 (rank : 448)	NC score	0.757462 (rank : 321)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	752
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KCC1G_HUMAN
θ value	2.21117e-06 (rank : 449)	NC score	0.712965 (rank : 508)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	753
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MOS_MOUSE
θ value	2.21117e-06 (rank : 450)	NC score	0.857921 (rank : 184)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PAK1_HUMAN
θ value	2.21117e-06 (rank : 451)	NC score	0.759505 (rank : 304)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	770
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

RK_MOUSE
θ value	2.21117e-06 (rank : 452)	NC score	0.695671 (rank : 597)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	744
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ST32B_HUMAN
θ value	2.21117e-06 (rank : 453)	NC score	0.709120 (rank : 529)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	747
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

TSSK1_MOUSE
θ value	2.21117e-06 (rank : 454)	NC score	0.739951 (rank : 400)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	752
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CDK6_MOUSE
θ value	2.88788e-06 (rank : 455)	NC score	0.736784 (rank : 413)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	749
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

DAPK3_MOUSE
θ value	2.88788e-06 (rank : 456)	NC score	0.726862 (rank : 456)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	739
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC2B_HUMAN
θ value	2.88788e-06 (rank : 457)	NC score	0.683418 (rank : 644)
Query Neighborhood Hits	1243	Target Neighborhood Hits	866	Shared Neighborhood Hits	754
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	2.88788e-06 (rank : 458)	NC score	0.681200 (rank : 654)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	741
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KS6B2_MOUSE
θ value	2.88788e-06 (rank : 459)	NC score	0.703350 (rank : 562)
Query Neighborhood Hits	1243	Target Neighborhood Hits	871	Shared Neighborhood Hits	764
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PHKG2_HUMAN
θ value	2.88788e-06 (rank : 460)	NC score	0.690399 (rank : 621)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	752
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

AURKC_HUMAN
θ value	3.77169e-06 (rank : 461)	NC score	0.756538 (rank : 326)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

CCRK_MOUSE
θ value	3.77169e-06 (rank : 462)	NC score	0.701061 (rank : 572)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	750
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

ILK_MOUSE
θ value	3.77169e-06 (rank : 463)	NC score	0.681093 (rank : 655)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	570
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

KS6A4_MOUSE
θ value	3.77169e-06 (rank : 464)	NC score	0.690957 (rank : 619)
Query Neighborhood Hits	1243	Target Neighborhood Hits	866	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MYO3B_HUMAN
θ value	3.77169e-06 (rank : 465)	NC score	0.650362 (rank : 718)
Query Neighborhood Hits	1243	Target Neighborhood Hits	923	Shared Neighborhood Hits	756
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

DAPK2_HUMAN
θ value	4.92598e-06 (rank : 466)	NC score	0.719749 (rank : 486)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	739
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	4.92598e-06 (rank : 467)	NC score	0.723017 (rank : 474)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	743
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

GRK6_HUMAN
θ value	4.92598e-06 (rank : 468)	NC score	0.709487 (rank : 525)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	745
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KCC1D_HUMAN
θ value	4.92598e-06 (rank : 469)	NC score	0.703159 (rank : 565)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	750
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	4.92598e-06 (rank : 470)	NC score	0.703164 (rank : 564)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	750
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

SGK1_HUMAN
θ value	4.92598e-06 (rank : 471)	NC score	0.709490 (rank : 524)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	755
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

TNI3K_MOUSE
θ value	4.92598e-06 (rank : 472)	NC score	0.773370 (rank : 259)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1079	Shared Neighborhood Hits	740
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ANKK1_MOUSE
θ value	6.43352e-06 (rank : 473)	NC score	0.691242 (rank : 618)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1072	Shared Neighborhood Hits	742
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

CDK10_HUMAN
θ value	6.43352e-06 (rank : 474)	NC score	0.718669 (rank : 495)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	747
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

GRK6_MOUSE
θ value	6.43352e-06 (rank : 475)	NC score	0.709383 (rank : 527)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	746
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ILK1_HUMAN
θ value	6.43352e-06 (rank : 476)	NC score	0.679849 (rank : 659)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	569
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

KS6A4_HUMAN
θ value	6.43352e-06 (rank : 477)	NC score	0.689813 (rank : 628)
Query Neighborhood Hits	1243	Target Neighborhood Hits	868	Shared Neighborhood Hits	765
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

M4K1_MOUSE
θ value	6.43352e-06 (rank : 478)	NC score	0.763842 (rank : 285)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	765
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K5_HUMAN
θ value	6.43352e-06 (rank : 479)	NC score	0.746704 (rank : 381)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	756
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PCTK3_MOUSE
θ value	6.43352e-06 (rank : 480)	NC score	0.722551 (rank : 475)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	749
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

SGK1_MOUSE
θ value	6.43352e-06 (rank : 481)	NC score	0.708495 (rank : 532)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	756
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SN1L1_MOUSE
θ value	6.43352e-06 (rank : 482)	NC score	0.751501 (rank : 352)
Query Neighborhood Hits	1243	Target Neighborhood Hits	895	Shared Neighborhood Hits	766
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	6.43352e-06 (rank : 483)	NC score	0.753947 (rank : 339)
Query Neighborhood Hits	1243	Target Neighborhood Hits	964	Shared Neighborhood Hits	787
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

STK11_HUMAN
θ value	6.43352e-06 (rank : 484)	NC score	0.750233 (rank : 358)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	749
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

TSSK4_HUMAN
θ value	6.43352e-06 (rank : 485)	NC score	0.751434 (rank : 354)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	750
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

ULK3_HUMAN
θ value	6.43352e-06 (rank : 486)	NC score	0.770365 (rank : 267)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	750
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

CDK6_HUMAN
θ value	8.40245e-06 (rank : 487)	NC score	0.733813 (rank : 432)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	749
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

KCC2A_HUMAN
θ value	8.40245e-06 (rank : 488)	NC score	0.687269 (rank : 632)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	742
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

M3K1_MOUSE
θ value	8.40245e-06 (rank : 489)	NC score	0.771982 (rank : 263)
Query Neighborhood Hits	1243	Target Neighborhood Hits	952	Shared Neighborhood Hits	777
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MP2K5_MOUSE
θ value	8.40245e-06 (rank : 490)	NC score	0.785650 (rank : 237)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PGCA_HUMAN
θ value	8.40245e-06 (rank : 491)	NC score	0.029653 (rank : 1289)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	129
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

TNI3K_HUMAN
θ value	8.40245e-06 (rank : 492)	NC score	0.769085 (rank : 270)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1084	Shared Neighborhood Hits	742
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CDKL5_HUMAN
θ value	1.09739e-05 (rank : 493)	NC score	0.708809 (rank : 530)
Query Neighborhood Hits	1243	Target Neighborhood Hits	967	Shared Neighborhood Hits	770
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

DAPK3_HUMAN
θ value	1.09739e-05 (rank : 494)	NC score	0.726795 (rank : 457)
Query Neighborhood Hits	1243	Target Neighborhood Hits	945	Shared Neighborhood Hits	743
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

IKKE_HUMAN
θ value	1.09739e-05 (rank : 495)	NC score	0.748857 (rank : 362)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	740
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KAPCG_HUMAN
θ value	1.09739e-05 (rank : 496)	NC score	0.710998 (rank : 517)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	754
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KPSH1_HUMAN
θ value	1.09739e-05 (rank : 497)	NC score	0.699461 (rank : 579)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	744
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MP2K4_HUMAN
θ value	1.09739e-05 (rank : 498)	NC score	0.757606 (rank : 319)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	751
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	1.09739e-05 (rank : 499)	NC score	0.757617 (rank : 318)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MUC1_HUMAN
θ value	1.09739e-05 (rank : 500)	NC score	0.081743 (rank : 1009)
Query Neighborhood Hits	1243	Target Neighborhood Hits	975	Shared Neighborhood Hits	297
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PAK3_HUMAN
θ value	1.09739e-05 (rank : 501)	NC score	0.756226 (rank : 330)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	772
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	1.09739e-05 (rank : 502)	NC score	0.756406 (rank : 328)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	768
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

SN1L2_MOUSE
θ value	1.09739e-05 (rank : 503)	NC score	0.750835 (rank : 357)
Query Neighborhood Hits	1243	Target Neighborhood Hits	944	Shared Neighborhood Hits	779
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

TBK1_HUMAN
θ value	1.09739e-05 (rank : 504)	NC score	0.734783 (rank : 429)
Query Neighborhood Hits	1243	Target Neighborhood Hits	861	Shared Neighborhood Hits	734
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	1.09739e-05 (rank : 505)	NC score	0.732933 (rank : 437)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	734
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

CDKL3_HUMAN
θ value	1.43324e-05 (rank : 506)	NC score	0.728929 (rank : 451)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	751
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

M4K1_HUMAN
θ value	1.43324e-05 (rank : 507)	NC score	0.763677 (rank : 287)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	766
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MK09_HUMAN
θ value	1.43324e-05 (rank : 508)	NC score	0.677651 (rank : 669)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	752
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

PDPK1_HUMAN
θ value	1.43324e-05 (rank : 509)	NC score	0.730854 (rank : 446)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	753
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	1.43324e-05 (rank : 510)	NC score	0.731648 (rank : 441)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	754
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

RIPK2_HUMAN
θ value	1.43324e-05 (rank : 511)	NC score	0.844022 (rank : 197)
Query Neighborhood Hits	1243	Target Neighborhood Hits	774	Shared Neighborhood Hits	709
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

AVR2B_HUMAN
θ value	1.87187e-05 (rank : 512)	NC score	0.704013 (rank : 557)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	702
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	1.87187e-05 (rank : 513)	NC score	0.704236 (rank : 556)
Query Neighborhood Hits	1243	Target Neighborhood Hits	749	Shared Neighborhood Hits	702
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

GRK5_HUMAN
θ value	1.87187e-05 (rank : 514)	NC score	0.701378 (rank : 571)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	739
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	1.87187e-05 (rank : 515)	NC score	0.701581 (rank : 570)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	739
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KCC2A_MOUSE
θ value	1.87187e-05 (rank : 516)	NC score	0.684247 (rank : 641)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	740
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

ST17A_HUMAN
θ value	1.87187e-05 (rank : 517)	NC score	0.714728 (rank : 504)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	739
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

AMHR2_HUMAN
θ value	2.44474e-05 (rank : 518)	NC score	0.695869 (rank : 596)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	646
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

CDKL3_MOUSE
θ value	2.44474e-05 (rank : 519)	NC score	0.725996 (rank : 464)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	750
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

SGK3_MOUSE
θ value	2.44474e-05 (rank : 520)	NC score	0.692564 (rank : 608)
Query Neighborhood Hits	1243	Target Neighborhood Hits	882	Shared Neighborhood Hits	752
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

WEE1_HUMAN
θ value	2.44474e-05 (rank : 521)	NC score	0.653225 (rank : 712)
Query Neighborhood Hits	1243	Target Neighborhood Hits	777	Shared Neighborhood Hits	671
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

CDK3_MOUSE
θ value	3.19293e-05 (rank : 522)	NC score	0.735324 (rank : 423)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	750
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_MOUSE
θ value	3.19293e-05 (rank : 523)	NC score	0.728869 (rank : 452)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	750
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

KAPCA_HUMAN
θ value	3.19293e-05 (rank : 524)	NC score	0.698740 (rank : 584)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	753
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KPCD2_HUMAN
θ value	3.19293e-05 (rank : 525)	NC score	0.709195 (rank : 528)
Query Neighborhood Hits	1243	Target Neighborhood Hits	910	Shared Neighborhood Hits	753
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

MK09_MOUSE
θ value	3.19293e-05 (rank : 526)	NC score	0.675054 (rank : 675)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	751
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

SBK1_MOUSE
θ value	3.19293e-05 (rank : 527)	NC score	0.721839 (rank : 478)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	734
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SGK2_HUMAN
θ value	3.19293e-05 (rank : 528)	NC score	0.696617 (rank : 592)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	752
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SN1L1_HUMAN
θ value	3.19293e-05 (rank : 529)	NC score	0.746690 (rank : 382)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	770
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

BMP2K_MOUSE
θ value	4.1701e-05 (rank : 530)	NC score	0.671403 (rank : 678)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	720
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CDK2_MOUSE
θ value	4.1701e-05 (rank : 531)	NC score	0.735517 (rank : 421)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	749
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

KCC2D_HUMAN
θ value	4.1701e-05 (rank : 532)	NC score	0.683343 (rank : 645)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	742
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KS6B1_HUMAN
θ value	4.1701e-05 (rank : 533)	NC score	0.713738 (rank : 506)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	757
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	4.1701e-05 (rank : 534)	NC score	0.713818 (rank : 505)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	757
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

OBSCN_HUMAN
θ value	4.1701e-05 (rank : 535)	NC score	0.627987 (rank : 738)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1931	Shared Neighborhood Hits	927
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SGK2_MOUSE
θ value	4.1701e-05 (rank : 536)	NC score	0.696433 (rank : 594)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	749
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

TTK_MOUSE
θ value	4.1701e-05 (rank : 537)	NC score	0.677938 (rank : 667)
Query Neighborhood Hits	1243	Target Neighborhood Hits	803	Shared Neighborhood Hits	694
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

GUC2G_MOUSE
θ value	5.44631e-05 (rank : 538)	NC score	0.678813 (rank : 662)
Query Neighborhood Hits	1243	Target Neighborhood Hits	644	Shared Neighborhood Hits	571
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

KAPCB_MOUSE
θ value	5.44631e-05 (rank : 539)	NC score	0.698736 (rank : 585)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	753
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

RIPK3_MOUSE
θ value	5.44631e-05 (rank : 540)	NC score	0.823648 (rank : 206)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	766
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

TSSK3_MOUSE
θ value	5.44631e-05 (rank : 541)	NC score	0.682586 (rank : 649)
Query Neighborhood Hits	1243	Target Neighborhood Hits	806	Shared Neighborhood Hits	732
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TTK_HUMAN
θ value	5.44631e-05 (rank : 542)	NC score	0.693553 (rank : 606)
Query Neighborhood Hits	1243	Target Neighborhood Hits	816	Shared Neighborhood Hits	707
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

WEE1_MOUSE
θ value	5.44631e-05 (rank : 543)	NC score	0.678063 (rank : 665)
Query Neighborhood Hits	1243	Target Neighborhood Hits	794	Shared Neighborhood Hits	691
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

GRK4_MOUSE
θ value	7.1131e-05 (rank : 544)	NC score	0.709890 (rank : 521)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	736
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

KKCC2_HUMAN
θ value	7.1131e-05 (rank : 545)	NC score	0.740200 (rank : 398)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	756
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	7.1131e-05 (rank : 546)	NC score	0.740485 (rank : 397)
Query Neighborhood Hits	1243	Target Neighborhood Hits	855	Shared Neighborhood Hits	757
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

MK10_HUMAN
θ value	7.1131e-05 (rank : 547)	NC score	0.682698 (rank : 647)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	749
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	7.1131e-05 (rank : 548)	NC score	0.682981 (rank : 646)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	751
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

NEK11_MOUSE
θ value	7.1131e-05 (rank : 549)	NC score	0.809273 (rank : 211)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	758
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

ROCK1_HUMAN
θ value	7.1131e-05 (rank : 550)	NC score	0.589964 (rank : 767)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2000	Shared Neighborhood Hits	797
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	7.1131e-05 (rank : 551)	NC score	0.577553 (rank : 775)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2126	Shared Neighborhood Hits	799
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

AL2S7_HUMAN
θ value	9.29e-05 (rank : 552)	NC score	0.733233 (rank : 435)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	744
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

E2AK4_MOUSE
θ value	9.29e-05 (rank : 553)	NC score	0.716235 (rank : 501)
Query Neighborhood Hits	1243	Target Neighborhood Hits	984	Shared Neighborhood Hits	767
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

GRK4_HUMAN
θ value	9.29e-05 (rank : 554)	NC score	0.703614 (rank : 560)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	738
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

KAPCB_HUMAN
θ value	9.29e-05 (rank : 555)	NC score	0.700372 (rank : 575)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	753
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KCC2G_HUMAN
θ value	9.29e-05 (rank : 556)	NC score	0.691832 (rank : 612)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	748
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	9.29e-05 (rank : 557)	NC score	0.691808 (rank : 614)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

ST32C_MOUSE
θ value	9.29e-05 (rank : 558)	NC score	0.702847 (rank : 566)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	743
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

TSSK1_HUMAN
θ value	9.29e-05 (rank : 559)	NC score	0.711402 (rank : 514)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	744
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_MOUSE
θ value	9.29e-05 (rank : 560)	NC score	0.717920 (rank : 496)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	743
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK3_HUMAN
θ value	9.29e-05 (rank : 561)	NC score	0.680672 (rank : 657)
Query Neighborhood Hits	1243	Target Neighborhood Hits	806	Shared Neighborhood Hits	732
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CDK4_HUMAN
θ value	0.000121331 (rank : 562)	NC score	0.723517 (rank : 473)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	748
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

E2AK4_HUMAN
θ value	0.000121331 (rank : 563)	NC score	0.729040 (rank : 450)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1012	Shared Neighborhood Hits	770
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MK08_HUMAN
θ value	0.000121331 (rank : 564)	NC score	0.678097 (rank : 664)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	750
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	0.000121331 (rank : 565)	NC score	0.678638 (rank : 663)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	750
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

ST17B_HUMAN
θ value	0.000121331 (rank : 566)	NC score	0.724054 (rank : 471)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	743
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

TSSK6_MOUSE
θ value	0.000121331 (rank : 567)	NC score	0.728202 (rank : 453)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	744
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

DCAK3_HUMAN
θ value	0.000158464 (rank : 568)	NC score	0.708165 (rank : 537)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	755
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KAPCA_MOUSE
θ value	0.000158464 (rank : 569)	NC score	0.698187 (rank : 586)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	751
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MK03_HUMAN
θ value	0.000158464 (rank : 570)	NC score	0.711115 (rank : 515)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	752
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MOS_HUMAN
θ value	0.000158464 (rank : 571)	NC score	0.860485 (rank : 182)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	753
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

SPEG_MOUSE
θ value	0.000158464 (rank : 572)	NC score	0.644918 (rank : 722)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1959	Shared Neighborhood Hits	950
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STK38_MOUSE
θ value	0.000158464 (rank : 573)	NC score	0.629433 (rank : 732)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	727
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

CD2L1_MOUSE
θ value	0.00020696 (rank : 574)	NC score	0.703867 (rank : 559)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1463	Shared Neighborhood Hits	775
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CDK3_HUMAN
θ value	0.00020696 (rank : 575)	NC score	0.734601 (rank : 430)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	753
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CTRO_HUMAN
θ value	0.00020696 (rank : 576)	NC score	0.594691 (rank : 766)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2092	Shared Neighborhood Hits	811
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MK03_MOUSE
θ value	0.00020696 (rank : 577)	NC score	0.709944 (rank : 520)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	752
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MKNK1_MOUSE
θ value	0.00020696 (rank : 578)	NC score	0.621501 (rank : 743)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	723
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MOK_HUMAN
θ value	0.00020696 (rank : 579)	NC score	0.686321 (rank : 635)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	724
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

SNRK_MOUSE
θ value	0.00020696 (rank : 580)	NC score	0.719046 (rank : 491)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	742
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

ST32C_HUMAN
θ value	0.00020696 (rank : 581)	NC score	0.698064 (rank : 588)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	746
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

STK38_HUMAN
θ value	0.00020696 (rank : 582)	NC score	0.628658 (rank : 734)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	727
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KCC1A_HUMAN
θ value	0.000270298 (rank : 583)	NC score	0.708174 (rank : 536)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	752
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	0.000270298 (rank : 584)	NC score	0.707893 (rank : 538)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	752
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

MK12_HUMAN
θ value	0.000270298 (rank : 585)	NC score	0.701900 (rank : 568)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	749
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

ROCK2_HUMAN
θ value	0.000270298 (rank : 586)	NC score	0.587494 (rank : 768)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2073	Shared Neighborhood Hits	805
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SGK3_HUMAN
θ value	0.000270298 (rank : 587)	NC score	0.689981 (rank : 626)
Query Neighborhood Hits	1243	Target Neighborhood Hits	877	Shared Neighborhood Hits	752
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

CD2L2_HUMAN
θ value	0.00035302 (rank : 588)	NC score	0.704993 (rank : 552)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1439	Shared Neighborhood Hits	778
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CHK2_HUMAN
θ value	0.00035302 (rank : 589)	NC score	0.682629 (rank : 648)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	749
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

IKKE_MOUSE
θ value	0.00035302 (rank : 590)	NC score	0.747881 (rank : 367)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	740
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KCC1B_MOUSE
θ value	0.00035302 (rank : 591)	NC score	0.706380 (rank : 543)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	751
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KPCD3_HUMAN
θ value	0.00035302 (rank : 592)	NC score	0.696649 (rank : 591)
Query Neighborhood Hits	1243	Target Neighborhood Hits	895	Shared Neighborhood Hits	748
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

MK14_HUMAN
θ value	0.00035302 (rank : 593)	NC score	0.703968 (rank : 558)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	753
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MLKL_HUMAN
θ value	0.00035302 (rank : 594)	NC score	0.812724 (rank : 210)
Query Neighborhood Hits	1243	Target Neighborhood Hits	600	Shared Neighborhood Hits	548
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MP2K3_MOUSE
θ value	0.00035302 (rank : 595)	NC score	0.747291 (rank : 371)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	749
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

ST38L_HUMAN
θ value	0.00035302 (rank : 596)	NC score	0.623457 (rank : 740)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	721
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TSSK6_HUMAN
θ value	0.00035302 (rank : 597)	NC score	0.726507 (rank : 459)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	743
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

AVR2A_HUMAN
θ value	0.000461057 (rank : 598)	NC score	0.735318 (rank : 424)
Query Neighborhood Hits	1243	Target Neighborhood Hits	767	Shared Neighborhood Hits	714
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	0.000461057 (rank : 599)	NC score	0.735330 (rank : 422)
Query Neighborhood Hits	1243	Target Neighborhood Hits	767	Shared Neighborhood Hits	714
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

CD2L1_HUMAN
θ value	0.000461057 (rank : 600)	NC score	0.703468 (rank : 561)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1467	Shared Neighborhood Hits	777
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CDK2_HUMAN
θ value	0.000461057 (rank : 601)	NC score	0.733051 (rank : 436)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	754
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

GAK_HUMAN
θ value	0.000461057 (rank : 602)	NC score	0.686827 (rank : 633)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1028	Shared Neighborhood Hits	803
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GUC2D_HUMAN
θ value	0.000461057 (rank : 603)	NC score	0.672529 (rank : 677)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	645
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

MK15_HUMAN
θ value	0.000461057 (rank : 604)	NC score	0.700038 (rank : 578)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1038	Shared Neighborhood Hits	813
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

AAK1_MOUSE
θ value	0.000602161 (rank : 605)	NC score	0.661407 (rank : 697)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1051	Shared Neighborhood Hits	799
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

GAK_MOUSE
θ value	0.000602161 (rank : 606)	NC score	0.669743 (rank : 687)
Query Neighborhood Hits	1243	Target Neighborhood Hits	964	Shared Neighborhood Hits	765
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KCC1B_HUMAN
θ value	0.000602161 (rank : 607)	NC score	0.704972 (rank : 553)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	751
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KPCD3_MOUSE
θ value	0.000602161 (rank : 608)	NC score	0.695137 (rank : 599)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	745
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

MK12_MOUSE
θ value	0.000602161 (rank : 609)	NC score	0.700054 (rank : 577)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	751
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MP2K6_HUMAN
θ value	0.000602161 (rank : 610)	NC score	0.748604 (rank : 365)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	749
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PRDM2_HUMAN
θ value	0.000602161 (rank : 611)	NC score	-0.005955 (rank : 1594)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1135	Shared Neighborhood Hits	116
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

SNRK_HUMAN
θ value	0.000602161 (rank : 612)	NC score	0.717740 (rank : 497)
Query Neighborhood Hits	1243	Target Neighborhood Hits	855	Shared Neighborhood Hits	741
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

BRSK2_HUMAN
θ value	0.000786445 (rank : 613)	NC score	0.734909 (rank : 428)
Query Neighborhood Hits	1243	Target Neighborhood Hits	897	Shared Neighborhood Hits	764
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CD2L6_HUMAN
θ value	0.000786445 (rank : 614)	NC score	0.669906 (rank : 686)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	744
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	0.000786445 (rank : 615)	NC score	0.670032 (rank : 685)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	747
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CLK1_MOUSE
θ value	0.000786445 (rank : 616)	NC score	0.550515 (rank : 790)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	679
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

ERN2_MOUSE
θ value	0.000786445 (rank : 617)	NC score	0.681408 (rank : 653)
Query Neighborhood Hits	1243	Target Neighborhood Hits	825	Shared Neighborhood Hits	736
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MOK_MOUSE
θ value	0.000786445 (rank : 618)	NC score	0.685314 (rank : 637)
Query Neighborhood Hits	1243	Target Neighborhood Hits	796	Shared Neighborhood Hits	719
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

RIPK5_HUMAN
θ value	0.000786445 (rank : 619)	NC score	0.831021 (rank : 204)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	758
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	0.000786445 (rank : 620)	NC score	0.830261 (rank : 205)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	758
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ROCK2_MOUSE
θ value	0.000786445 (rank : 621)	NC score	0.580586 (rank : 772)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2072	Shared Neighborhood Hits	800
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

ST17B_MOUSE
θ value	0.000786445 (rank : 622)	NC score	0.735250 (rank : 425)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK16_MOUSE
θ value	0.000786445 (rank : 623)	NC score	0.759110 (rank : 305)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	745
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

BRSK1_HUMAN
θ value	0.00102713 (rank : 624)	NC score	0.732090 (rank : 440)
Query Neighborhood Hits	1243	Target Neighborhood Hits	942	Shared Neighborhood Hits	775
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CTRO_MOUSE
θ value	0.00102713 (rank : 625)	NC score	0.576423 (rank : 778)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2344	Shared Neighborhood Hits	829
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GNAS1_MOUSE
θ value	0.00102713 (rank : 626)	NC score	0.032141 (rank : 1270)
Query Neighborhood Hits	1243	Target Neighborhood Hits	651	Shared Neighborhood Hits	211
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

GRK7_HUMAN
θ value	0.00102713 (rank : 627)	NC score	0.672830 (rank : 676)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	745
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KPCD1_HUMAN
θ value	0.00102713 (rank : 628)	NC score	0.700766 (rank : 574)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	749
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MK14_MOUSE
θ value	0.00102713 (rank : 629)	NC score	0.702634 (rank : 567)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	753
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

PGCA_MOUSE
θ value	0.00102713 (rank : 630)	NC score	0.019112 (rank : 1370)
Query Neighborhood Hits	1243	Target Neighborhood Hits	643	Shared Neighborhood Hits	98
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

WBP11_MOUSE
θ value	0.00102713 (rank : 631)	NC score	0.054008 (rank : 1144)
Query Neighborhood Hits	1243	Target Neighborhood Hits	362	Shared Neighborhood Hits	102
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

KC1E_HUMAN
θ value	0.00134147 (rank : 632)	NC score	0.554282 (rank : 788)
Query Neighborhood Hits	1243	Target Neighborhood Hits	732	Shared Neighborhood Hits	659
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	0.00134147 (rank : 633)	NC score	0.554297 (rank : 787)
Query Neighborhood Hits	1243	Target Neighborhood Hits	728	Shared Neighborhood Hits	659
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KPCD1_MOUSE
θ value	0.00134147 (rank : 634)	NC score	0.698109 (rank : 587)
Query Neighborhood Hits	1243	Target Neighborhood Hits	891	Shared Neighborhood Hits	748
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MK01_HUMAN
θ value	0.00134147 (rank : 635)	NC score	0.709468 (rank : 526)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	751
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MP2K3_HUMAN
θ value	0.00134147 (rank : 636)	NC score	0.746680 (rank : 383)
Query Neighborhood Hits	1243	Target Neighborhood Hits	825	Shared Neighborhood Hits	749
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

WBP11_HUMAN
θ value	0.00134147 (rank : 637)	NC score	0.054360 (rank : 1140)
Query Neighborhood Hits	1243	Target Neighborhood Hits	354	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

DMPK_MOUSE
θ value	0.00175202 (rank : 638)	NC score	0.628160 (rank : 736)
Query Neighborhood Hits	1243	Target Neighborhood Hits	908	Shared Neighborhood Hits	747
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ERN2_HUMAN
θ value	0.00175202 (rank : 639)	NC score	0.680644 (rank : 658)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	741
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK01_MOUSE
θ value	0.00175202 (rank : 640)	NC score	0.709730 (rank : 522)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	751
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK11_MOUSE
θ value	0.00175202 (rank : 641)	NC score	0.689538 (rank : 630)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	748
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

CPSF6_HUMAN
θ value	0.00228821 (rank : 642)	NC score	0.042031 (rank : 1207)
Query Neighborhood Hits	1243	Target Neighborhood Hits	359	Shared Neighborhood Hits	104
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

DMPK_HUMAN
θ value	0.00228821 (rank : 643)	NC score	0.625786 (rank : 739)
Query Neighborhood Hits	1243	Target Neighborhood Hits	944	Shared Neighborhood Hits	750
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

GUC2E_MOUSE
θ value	0.00228821 (rank : 644)	NC score	0.670114 (rank : 683)
Query Neighborhood Hits	1243	Target Neighborhood Hits	692	Shared Neighborhood Hits	623
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

MK06_HUMAN
θ value	0.00228821 (rank : 645)	NC score	0.684410 (rank : 639)
Query Neighborhood Hits	1243	Target Neighborhood Hits	815	Shared Neighborhood Hits	718
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MLKL_MOUSE
θ value	0.00228821 (rank : 646)	NC score	0.846567 (rank : 195)
Query Neighborhood Hits	1243	Target Neighborhood Hits	707	Shared Neighborhood Hits	660
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MP2K6_MOUSE
θ value	0.00228821 (rank : 647)	NC score	0.747276 (rank : 372)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	750
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

TMUB1_HUMAN
θ value	0.00228821 (rank : 648)	NC score	0.026540 (rank : 1307)
Query Neighborhood Hits	1243	Target Neighborhood Hits	30	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BVT8	Gene names	TMUB1, C7orf21
Domain Architecture
Description	Transmembrane and ubiquitin-like domain-containing protein 1 (Ubiquitin-like protein SB144).

WDR33_HUMAN
θ value	0.00228821 (rank : 649)	NC score	0.009996 (rank : 1446)
Query Neighborhood Hits	1243	Target Neighborhood Hits	638	Shared Neighborhood Hits	115
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

CD2L7_HUMAN
θ value	0.00298849 (rank : 650)	NC score	0.736987 (rank : 412)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1275	Shared Neighborhood Hits	836
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CEND3_MOUSE
θ value	0.00298849 (rank : 651)	NC score	0.035327 (rank : 1243)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

E2AK2_HUMAN
θ value	0.00298849 (rank : 652)	NC score	0.785614 (rank : 238)
Query Neighborhood Hits	1243	Target Neighborhood Hits	856	Shared Neighborhood Hits	749
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

ERN1_MOUSE
θ value	0.00298849 (rank : 653)	NC score	0.701887 (rank : 569)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	736
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KC1D_HUMAN
θ value	0.00298849 (rank : 654)	NC score	0.557616 (rank : 785)
Query Neighborhood Hits	1243	Target Neighborhood Hits	737	Shared Neighborhood Hits	661
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	0.00298849 (rank : 655)	NC score	0.557615 (rank : 786)
Query Neighborhood Hits	1243	Target Neighborhood Hits	737	Shared Neighborhood Hits	661
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KGP2_HUMAN
θ value	0.00298849 (rank : 656)	NC score	0.691469 (rank : 615)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1023	Shared Neighborhood Hits	769
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

LATS1_HUMAN
θ value	0.00298849 (rank : 657)	NC score	0.622212 (rank : 741)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1057	Shared Neighborhood Hits	795
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

MRCKB_MOUSE
θ value	0.00298849 (rank : 658)	NC score	0.575335 (rank : 780)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2180	Shared Neighborhood Hits	815
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PFTK1_MOUSE
θ value	0.00298849 (rank : 659)	NC score	0.725098 (rank : 467)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	744
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PRB3_HUMAN
θ value	0.00298849 (rank : 660)	NC score	0.056634 (rank : 1119)
Query Neighborhood Hits	1243	Target Neighborhood Hits	318	Shared Neighborhood Hits	102
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

ST38L_MOUSE
θ value	0.00298849 (rank : 661)	NC score	0.608577 (rank : 753)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	715
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TRIO_HUMAN
θ value	0.00298849 (rank : 662)	NC score	0.616572 (rank : 746)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1580	Shared Neighborhood Hits	788
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ULK4_MOUSE
θ value	0.00298849 (rank : 663)	NC score	0.665609 (rank : 690)
Query Neighborhood Hits	1243	Target Neighborhood Hits	793	Shared Neighborhood Hits	706
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

AB1IP_MOUSE
θ value	0.00390308 (rank : 664)	NC score	0.028639 (rank : 1293)
Query Neighborhood Hits	1243	Target Neighborhood Hits	181	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CD2L5_HUMAN
θ value	0.00390308 (rank : 665)	NC score	0.736567 (rank : 414)
Query Neighborhood Hits	1243	Target Neighborhood Hits	987	Shared Neighborhood Hits	770
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	0.00390308 (rank : 666)	NC score	0.736414 (rank : 415)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1011	Shared Neighborhood Hits	772
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CHK2_MOUSE
θ value	0.00390308 (rank : 667)	NC score	0.688255 (rank : 631)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	752
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

E2AK3_MOUSE
θ value	0.00390308 (rank : 668)	NC score	0.747845 (rank : 368)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	753
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

FOG1_HUMAN
θ value	0.00390308 (rank : 669)	NC score	-0.006451 (rank : 1595)
Query Neighborhood Hits	1243	Target Neighborhood Hits	981	Shared Neighborhood Hits	102
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

LATS1_MOUSE
θ value	0.00390308 (rank : 670)	NC score	0.617000 (rank : 745)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1027	Shared Neighborhood Hits	775
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

MK06_MOUSE
θ value	0.00390308 (rank : 671)	NC score	0.684276 (rank : 640)
Query Neighborhood Hits	1243	Target Neighborhood Hits	818	Shared Neighborhood Hits	719
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

PFTK1_HUMAN
θ value	0.00390308 (rank : 672)	NC score	0.724231 (rank : 470)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	744
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

SAPS1_HUMAN
θ value	0.00390308 (rank : 673)	NC score	0.049073 (rank : 1183)
Query Neighborhood Hits	1243	Target Neighborhood Hits	704	Shared Neighborhood Hits	241
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SFPQ_MOUSE
θ value	0.00390308 (rank : 674)	NC score	0.040966 (rank : 1212)
Query Neighborhood Hits	1243	Target Neighborhood Hits	958	Shared Neighborhood Hits	166
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SPEG_HUMAN
θ value	0.00390308 (rank : 675)	NC score	0.648128 (rank : 721)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1762	Shared Neighborhood Hits	905
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WEE1B_MOUSE
θ value	0.00390308 (rank : 676)	NC score	0.628043 (rank : 737)
Query Neighborhood Hits	1243	Target Neighborhood Hits	765	Shared Neighborhood Hits	675
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CDC27_HUMAN
θ value	0.00509761 (rank : 677)	NC score	0.013807 (rank : 1417)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	12
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

CDK8_HUMAN
θ value	0.00509761 (rank : 678)	NC score	0.665250 (rank : 691)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	741
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CLK1_HUMAN
θ value	0.00509761 (rank : 679)	NC score	0.543248 (rank : 794)
Query Neighborhood Hits	1243	Target Neighborhood Hits	756	Shared Neighborhood Hits	671
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CPSF6_MOUSE
θ value	0.00509761 (rank : 680)	NC score	0.041779 (rank : 1208)
Query Neighborhood Hits	1243	Target Neighborhood Hits	356	Shared Neighborhood Hits	105
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

PASK_HUMAN
θ value	0.00509761 (rank : 681)	NC score	0.711487 (rank : 513)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	750
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

ATN1_HUMAN
θ value	0.00665767 (rank : 682)	NC score	0.045461 (rank : 1192)
Query Neighborhood Hits	1243	Target Neighborhood Hits	676	Shared Neighborhood Hits	153
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

E2AK3_HUMAN
θ value	0.00665767 (rank : 683)	NC score	0.747170 (rank : 374)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	750
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

KGP2_MOUSE
θ value	0.00665767 (rank : 684)	NC score	0.690015 (rank : 625)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1029	Shared Neighborhood Hits	765
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PRB4S_HUMAN
θ value	0.00665767 (rank : 685)	NC score	0.059511 (rank : 1100)
Query Neighborhood Hits	1243	Target Neighborhood Hits	330	Shared Neighborhood Hits	101
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRP1_HUMAN
θ value	0.00665767 (rank : 686)	NC score	0.055011 (rank : 1135)
Query Neighborhood Hits	1243	Target Neighborhood Hits	385	Shared Neighborhood Hits	118
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

STK16_HUMAN
θ value	0.00665767 (rank : 687)	NC score	0.763726 (rank : 286)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	748
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

COHA1_HUMAN
θ value	0.00869519 (rank : 688)	NC score	0.039165 (rank : 1218)
Query Neighborhood Hits	1243	Target Neighborhood Hits	400	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

HXD3_HUMAN
θ value	0.00869519 (rank : 689)	NC score	-0.002975 (rank : 1580)
Query Neighborhood Hits	1243	Target Neighborhood Hits	433	Shared Neighborhood Hits	47
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

MCM4_MOUSE
θ value	0.00869519 (rank : 690)	NC score	0.008082 (rank : 1463)
Query Neighborhood Hits	1243	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	P49717, O89056	Gene names	Mcm4, Cdc21, Mcmd4
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MK11_HUMAN
θ value	0.00869519 (rank : 691)	NC score	0.694512 (rank : 605)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	745
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

PCLO_HUMAN
θ value	0.00869519 (rank : 692)	NC score	0.055908 (rank : 1124)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2046	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

TRIB1_HUMAN
θ value	0.00869519 (rank : 693)	NC score	0.491164 (rank : 813)
Query Neighborhood Hits	1243	Target Neighborhood Hits	598	Shared Neighborhood Hits	542
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

CDK7_HUMAN
θ value	0.0113563 (rank : 694)	NC score	0.718962 (rank : 492)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	749
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	0.0113563 (rank : 695)	NC score	0.720397 (rank : 484)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	749
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CLK4_HUMAN
θ value	0.0113563 (rank : 696)	NC score	0.551405 (rank : 789)
Query Neighborhood Hits	1243	Target Neighborhood Hits	759	Shared Neighborhood Hits	686
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

COCA1_MOUSE
θ value	0.0113563 (rank : 697)	NC score	0.050483 (rank : 1173)
Query Neighborhood Hits	1243	Target Neighborhood Hits	467	Shared Neighborhood Hits	126
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COHA1_MOUSE
θ value	0.0113563 (rank : 698)	NC score	0.042727 (rank : 1203)
Query Neighborhood Hits	1243	Target Neighborhood Hits	414	Shared Neighborhood Hits	124
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

IRAK2_HUMAN
θ value	0.0113563 (rank : 699)	NC score	0.705261 (rank : 550)
Query Neighborhood Hits	1243	Target Neighborhood Hits	714	Shared Neighborhood Hits	647
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

KKCC1_HUMAN
θ value	0.0113563 (rank : 700)	NC score	0.725124 (rank : 465)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	761
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MAST3_HUMAN
θ value	0.0113563 (rank : 701)	NC score	0.669084 (rank : 688)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1128	Shared Neighborhood Hits	814
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	0.0113563 (rank : 702)	NC score	0.664988 (rank : 692)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1804	Shared Neighborhood Hits	963
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MRCKB_HUMAN
θ value	0.0113563 (rank : 703)	NC score	0.569872 (rank : 781)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2239	Shared Neighborhood Hits	823
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PDCD7_HUMAN
θ value	0.0113563 (rank : 704)	NC score	0.036494 (rank : 1239)
Query Neighborhood Hits	1243	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

SFPQ_HUMAN
θ value	0.0113563 (rank : 705)	NC score	0.043128 (rank : 1202)
Query Neighborhood Hits	1243	Target Neighborhood Hits	986	Shared Neighborhood Hits	176
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

TOPK_HUMAN
θ value	0.0113563 (rank : 706)	NC score	0.759050 (rank : 306)
Query Neighborhood Hits	1243	Target Neighborhood Hits	605	Shared Neighborhood Hits	553
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

JADE2_MOUSE
θ value	0.0148317 (rank : 707)	NC score	0.024024 (rank : 1333)
Query Neighborhood Hits	1243	Target Neighborhood Hits	560	Shared Neighborhood Hits	149
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

K1802_HUMAN
θ value	0.0148317 (rank : 708)	NC score	0.026158 (rank : 1311)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1378	Shared Neighborhood Hits	256
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

KGP1A_HUMAN
θ value	0.0148317 (rank : 709)	NC score	0.695067 (rank : 601)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	756
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.0148317 (rank : 710)	NC score	0.694608 (rank : 604)
Query Neighborhood Hits	1243	Target Neighborhood Hits	921	Shared Neighborhood Hits	757
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	0.0148317 (rank : 711)	NC score	0.694644 (rank : 603)
Query Neighborhood Hits	1243	Target Neighborhood Hits	922	Shared Neighborhood Hits	757
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MP2K5_HUMAN
θ value	0.0148317 (rank : 712)	NC score	0.776055 (rank : 255)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	749
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K7_HUMAN
θ value	0.0148317 (rank : 713)	NC score	0.755550 (rank : 332)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	754
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

OGFR_HUMAN
θ value	0.0148317 (rank : 714)	NC score	0.089374 (rank : 992)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1582	Shared Neighborhood Hits	402
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TOPK_MOUSE
θ value	0.0148317 (rank : 715)	NC score	0.768828 (rank : 271)
Query Neighborhood Hits	1243	Target Neighborhood Hits	618	Shared Neighborhood Hits	569
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

ZXDB_HUMAN
θ value	0.0148317 (rank : 716)	NC score	-0.018747 (rank : 1614)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	39
SwissProt Accessions	P98169, Q9UBB3	Gene names	ZXDB
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDB.

CLK4_MOUSE
θ value	0.0193708 (rank : 717)	NC score	0.550076 (rank : 791)
Query Neighborhood Hits	1243	Target Neighborhood Hits	759	Shared Neighborhood Hits	684
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CO8A1_MOUSE
θ value	0.0193708 (rank : 718)	NC score	0.027505 (rank : 1299)
Query Neighborhood Hits	1243	Target Neighborhood Hits	251	Shared Neighborhood Hits	73
SwissProt Accessions	Q00780, Q9D2V4	Gene names	Col8a1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor.

ENAH_MOUSE
θ value	0.0193708 (rank : 719)	NC score	0.040793 (rank : 1213)
Query Neighborhood Hits	1243	Target Neighborhood Hits	919	Shared Neighborhood Hits	178
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

MAPK3_MOUSE
θ value	0.0193708 (rank : 720)	NC score	0.670282 (rank : 682)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	729
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MK04_HUMAN
θ value	0.0193708 (rank : 721)	NC score	0.699104 (rank : 581)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	741
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

TRIB2_HUMAN
θ value	0.0193708 (rank : 722)	NC score	0.543336 (rank : 793)
Query Neighborhood Hits	1243	Target Neighborhood Hits	657	Shared Neighborhood Hits	611
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	0.0193708 (rank : 723)	NC score	0.541785 (rank : 795)
Query Neighborhood Hits	1243	Target Neighborhood Hits	653	Shared Neighborhood Hits	607
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

VRK2_MOUSE
θ value	0.0193708 (rank : 724)	NC score	0.383417 (rank : 826)
Query Neighborhood Hits	1243	Target Neighborhood Hits	586	Shared Neighborhood Hits	540
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ZYX_HUMAN
θ value	0.0193708 (rank : 725)	NC score	0.024983 (rank : 1320)
Query Neighborhood Hits	1243	Target Neighborhood Hits	387	Shared Neighborhood Hits	85
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

CO1A1_HUMAN
θ value	0.0252991 (rank : 726)	NC score	0.038248 (rank : 1225)
Query Neighborhood Hits	1243	Target Neighborhood Hits	475	Shared Neighborhood Hits	123
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

COCA1_HUMAN
θ value	0.0252991 (rank : 727)	NC score	0.047550 (rank : 1186)
Query Neighborhood Hits	1243	Target Neighborhood Hits	458	Shared Neighborhood Hits	113
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

KKCC1_MOUSE
θ value	0.0252991 (rank : 728)	NC score	0.723991 (rank : 472)
Query Neighborhood Hits	1243	Target Neighborhood Hits	866	Shared Neighborhood Hits	762
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MAPK3_HUMAN
θ value	0.0252991 (rank : 729)	NC score	0.660791 (rank : 701)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	723
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

NACAM_MOUSE
θ value	0.0252991 (rank : 730)	NC score	0.064215 (rank : 1072)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1866	Shared Neighborhood Hits	381
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PCQAP_MOUSE
θ value	0.0252991 (rank : 731)	NC score	0.043498 (rank : 1198)
Query Neighborhood Hits	1243	Target Neighborhood Hits	506	Shared Neighborhood Hits	99
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PIM3_HUMAN
θ value	0.0252991 (rank : 732)	NC score	0.653752 (rank : 710)
Query Neighborhood Hits	1243	Target Neighborhood Hits	789	Shared Neighborhood Hits	716
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	0.0252991 (rank : 733)	NC score	0.644893 (rank : 723)
Query Neighborhood Hits	1243	Target Neighborhood Hits	783	Shared Neighborhood Hits	711
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

RP3A_HUMAN
θ value	0.0252991 (rank : 734)	NC score	0.024570 (rank : 1326)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

UHMK1_HUMAN
θ value	0.0252991 (rank : 735)	NC score	0.658290 (rank : 705)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	698
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	0.0252991 (rank : 736)	NC score	0.659309 (rank : 704)
Query Neighborhood Hits	1243	Target Neighborhood Hits	809	Shared Neighborhood Hits	698
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ANR11_HUMAN
θ value	0.0330416 (rank : 737)	NC score	0.023315 (rank : 1340)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1289	Shared Neighborhood Hits	184
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

MAPK5_MOUSE
θ value	0.0330416 (rank : 738)	NC score	0.605142 (rank : 756)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	717
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MRCKG_MOUSE
θ value	0.0330416 (rank : 739)	NC score	0.618255 (rank : 744)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1466	Shared Neighborhood Hits	769
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

OGFR_MOUSE
θ value	0.0330416 (rank : 740)	NC score	0.058111 (rank : 1109)
Query Neighborhood Hits	1243	Target Neighborhood Hits	584	Shared Neighborhood Hits	174
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

SMRC1_HUMAN
θ value	0.0330416 (rank : 741)	NC score	0.024680 (rank : 1325)
Query Neighborhood Hits	1243	Target Neighborhood Hits	375	Shared Neighborhood Hits	62
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

SMRC1_MOUSE
θ value	0.0330416 (rank : 742)	NC score	0.023624 (rank : 1337)
Query Neighborhood Hits	1243	Target Neighborhood Hits	459	Shared Neighborhood Hits	72
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

TRIB1_MOUSE
θ value	0.0330416 (rank : 743)	NC score	0.491443 (rank : 812)
Query Neighborhood Hits	1243	Target Neighborhood Hits	593	Shared Neighborhood Hits	543
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

ZYX_MOUSE
θ value	0.0330416 (rank : 744)	NC score	0.024383 (rank : 1329)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	68
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

CI079_HUMAN
θ value	0.0431538 (rank : 745)	NC score	0.030511 (rank : 1284)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	84
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

LBXCO_HUMAN
θ value	0.0431538 (rank : 746)	NC score	0.018938 (rank : 1371)
Query Neighborhood Hits	1243	Target Neighborhood Hits	167	Shared Neighborhood Hits	42
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

MAPK5_HUMAN
θ value	0.0431538 (rank : 747)	NC score	0.600237 (rank : 761)
Query Neighborhood Hits	1243	Target Neighborhood Hits	795	Shared Neighborhood Hits	713
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

PASK_MOUSE
θ value	0.0431538 (rank : 748)	NC score	0.711762 (rank : 511)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	748
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PDCD7_MOUSE
θ value	0.0431538 (rank : 749)	NC score	0.038144 (rank : 1227)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

PIM2_MOUSE
θ value	0.0431538 (rank : 750)	NC score	0.671066 (rank : 679)
Query Neighborhood Hits	1243	Target Neighborhood Hits	809	Shared Neighborhood Hits	729
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

RAPH1_HUMAN
θ value	0.0431538 (rank : 751)	NC score	0.040658 (rank : 1214)
Query Neighborhood Hits	1243	Target Neighborhood Hits	593	Shared Neighborhood Hits	146
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

ZXDA_HUMAN
θ value	0.0431538 (rank : 752)	NC score	-0.019049 (rank : 1615)
Query Neighborhood Hits	1243	Target Neighborhood Hits	750	Shared Neighborhood Hits	37
SwissProt Accessions	P98168, Q9UJP7	Gene names	ZXDA
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDA.

CECR2_HUMAN
θ value	0.0563607 (rank : 753)	NC score	0.039418 (rank : 1217)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	191
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CO4A4_HUMAN
θ value	0.0563607 (rank : 754)	NC score	0.042171 (rank : 1206)
Query Neighborhood Hits	1243	Target Neighborhood Hits	440	Shared Neighborhood Hits	134
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

DGKK_HUMAN
θ value	0.0563607 (rank : 755)	NC score	0.042304 (rank : 1205)
Query Neighborhood Hits	1243	Target Neighborhood Hits	378	Shared Neighborhood Hits	103
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DIAP1_HUMAN
θ value	0.0563607 (rank : 756)	NC score	0.023937 (rank : 1334)
Query Neighborhood Hits	1243	Target Neighborhood Hits	784	Shared Neighborhood Hits	128
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

E2AK1_HUMAN
θ value	0.0563607 (rank : 757)	NC score	0.738355 (rank : 404)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	741
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	0.0563607 (rank : 758)	NC score	0.736202 (rank : 417)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	739
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

FOXP4_MOUSE
θ value	0.0563607 (rank : 759)	NC score	0.004290 (rank : 1509)
Query Neighborhood Hits	1243	Target Neighborhood Hits	211	Shared Neighborhood Hits	35
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

MRCKG_HUMAN
θ value	0.0563607 (rank : 760)	NC score	0.615918 (rank : 747)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1519	Shared Neighborhood Hits	781
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

RBM12_HUMAN
θ value	0.0563607 (rank : 761)	NC score	0.025968 (rank : 1313)
Query Neighborhood Hits	1243	Target Neighborhood Hits	298	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

TEX14_MOUSE
θ value	0.0563607 (rank : 762)	NC score	0.664923 (rank : 693)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1333	Shared Neighborhood Hits	643
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CSF1_HUMAN
θ value	0.0736092 (rank : 763)	NC score	0.037853 (rank : 1229)
Query Neighborhood Hits	1243	Target Neighborhood Hits	258	Shared Neighborhood Hits	105
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

ERN1_HUMAN
θ value	0.0736092 (rank : 764)	NC score	0.705834 (rank : 544)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	738
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FOXC1_MOUSE
θ value	0.0736092 (rank : 765)	NC score	0.005426 (rank : 1490)
Query Neighborhood Hits	1243	Target Neighborhood Hits	218	Shared Neighborhood Hits	55
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

KCC4_MOUSE
θ value	0.0736092 (rank : 766)	NC score	0.681488 (rank : 652)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	750
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MK13_HUMAN
θ value	0.0736092 (rank : 767)	NC score	0.692015 (rank : 610)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	750
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	0.0736092 (rank : 768)	NC score	0.690887 (rank : 620)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	752
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

PRR3_HUMAN
θ value	0.0736092 (rank : 769)	NC score	0.024277 (rank : 1331)
Query Neighborhood Hits	1243	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	P79522, Q5RJB5	Gene names	PRR3, CAT56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

SOCS7_MOUSE
θ value	0.0736092 (rank : 770)	NC score	0.088089 (rank : 996)
Query Neighborhood Hits	1243	Target Neighborhood Hits	154	Shared Neighborhood Hits	45
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

TBX4_HUMAN
θ value	0.0736092 (rank : 771)	NC score	0.004807 (rank : 1503)
Query Neighborhood Hits	1243	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P57082	Gene names	TBX4
Domain Architecture
Description	T-box transcription factor TBX4 (T-box protein 4).

TRIB3_MOUSE
θ value	0.0736092 (rank : 772)	NC score	0.474880 (rank : 815)
Query Neighborhood Hits	1243	Target Neighborhood Hits	578	Shared Neighborhood Hits	531
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

WASL_MOUSE
θ value	0.0736092 (rank : 773)	NC score	0.044559 (rank : 1194)
Query Neighborhood Hits	1243	Target Neighborhood Hits	339	Shared Neighborhood Hits	113
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WEE1B_HUMAN
θ value	0.0736092 (rank : 774)	NC score	0.621507 (rank : 742)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	683
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

CO1A1_MOUSE
θ value	0.0961366 (rank : 775)	NC score	0.038004 (rank : 1228)
Query Neighborhood Hits	1243	Target Neighborhood Hits	457	Shared Neighborhood Hits	125
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO3A1_MOUSE
θ value	0.0961366 (rank : 776)	NC score	0.040968 (rank : 1211)
Query Neighborhood Hits	1243	Target Neighborhood Hits	466	Shared Neighborhood Hits	124
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

COFA1_HUMAN
θ value	0.0961366 (rank : 777)	NC score	0.034021 (rank : 1256)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	92
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

DYN1_HUMAN
θ value	0.0961366 (rank : 778)	NC score	0.019827 (rank : 1365)
Query Neighborhood Hits	1243	Target Neighborhood Hits	216	Shared Neighborhood Hits	72
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	0.0961366 (rank : 779)	NC score	0.016852 (rank : 1390)
Query Neighborhood Hits	1243	Target Neighborhood Hits	168	Shared Neighborhood Hits	52
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

GNAS1_HUMAN
θ value	0.0961366 (rank : 780)	NC score	0.011868 (rank : 1427)
Query Neighborhood Hits	1243	Target Neighborhood Hits	278	Shared Neighborhood Hits	80
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

K1802_MOUSE
θ value	0.0961366 (rank : 781)	NC score	0.038896 (rank : 1221)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1596	Shared Neighborhood Hits	306
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MK04_MOUSE
θ value	0.0961366 (rank : 782)	NC score	0.696326 (rank : 595)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	747
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MRCKA_HUMAN
θ value	0.0961366 (rank : 783)	NC score	0.587058 (rank : 769)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1999	Shared Neighborhood Hits	795
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

NFAC1_HUMAN
θ value	0.0961366 (rank : 784)	NC score	0.014995 (rank : 1406)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	91
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

PCLO_MOUSE
θ value	0.0961366 (rank : 785)	NC score	0.063622 (rank : 1076)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2275	Shared Neighborhood Hits	430
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PIM1_MOUSE
θ value	0.0961366 (rank : 786)	NC score	0.648270 (rank : 720)
Query Neighborhood Hits	1243	Target Neighborhood Hits	787	Shared Neighborhood Hits	708
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PINK1_MOUSE
θ value	0.0961366 (rank : 787)	NC score	0.660902 (rank : 700)
Query Neighborhood Hits	1243	Target Neighborhood Hits	726	Shared Neighborhood Hits	678
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PLXB1_MOUSE
θ value	0.0961366 (rank : 788)	NC score	0.028236 (rank : 1297)
Query Neighborhood Hits	1243	Target Neighborhood Hits	259	Shared Neighborhood Hits	85
SwissProt Accessions	Q8CJH3, Q6ZQC3, Q80ZZ1	Gene names	Plxnb1, Kiaa0407
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor.

PRR11_MOUSE
θ value	0.0961366 (rank : 789)	NC score	0.018190 (rank : 1381)
Query Neighborhood Hits	1243	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BHE0, Q3V3H1	Gene names	Prr11
Domain Architecture	No domain graphic available
Description	Proline-rich protein 11.

RANB9_HUMAN
θ value	0.0961366 (rank : 790)	NC score	0.022245 (rank : 1347)
Query Neighborhood Hits	1243	Target Neighborhood Hits	179	Shared Neighborhood Hits	64
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

RGS3_MOUSE
θ value	0.0961366 (rank : 791)	NC score	0.066873 (rank : 1061)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1621	Shared Neighborhood Hits	392
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SC24C_HUMAN
θ value	0.0961366 (rank : 792)	NC score	0.054472 (rank : 1139)
Query Neighborhood Hits	1243	Target Neighborhood Hits	662	Shared Neighborhood Hits	263
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SON_HUMAN
θ value	0.0961366 (rank : 793)	NC score	0.071989 (rank : 1039)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1568	Shared Neighborhood Hits	385
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SRBP1_MOUSE
θ value	0.0961366 (rank : 794)	NC score	0.026008 (rank : 1312)
Query Neighborhood Hits	1243	Target Neighborhood Hits	384	Shared Neighborhood Hits	126
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TREF1_HUMAN
θ value	0.0961366 (rank : 795)	NC score	0.004138 (rank : 1511)
Query Neighborhood Hits	1243	Target Neighborhood Hits	651	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PN7, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9	Gene names	TRERF1, RAPA, TREP132
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132) (Zinc finger protein rapa).

ATG9A_HUMAN
θ value	0.125558 (rank : 796)	NC score	0.017576 (rank : 1384)
Query Neighborhood Hits	1243	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z3C6, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7	Gene names	ATG9A, APG9L1
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 9A (APG9-like 1).

CI096_HUMAN
θ value	0.125558 (rank : 797)	NC score	0.732446 (rank : 439)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	727
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

HXA3_MOUSE
θ value	0.125558 (rank : 798)	NC score	0.000638 (rank : 1553)
Query Neighborhood Hits	1243	Target Neighborhood Hits	558	Shared Neighborhood Hits	90
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

KCC4_HUMAN
θ value	0.125558 (rank : 799)	NC score	0.685036 (rank : 638)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	747
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

LRP3_HUMAN
θ value	0.125558 (rank : 800)	NC score	0.003413 (rank : 1517)
Query Neighborhood Hits	1243	Target Neighborhood Hits	280	Shared Neighborhood Hits	43
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

MBD6_HUMAN
θ value	0.125558 (rank : 801)	NC score	0.049820 (rank : 1180)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	99
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

PCQAP_HUMAN
θ value	0.125558 (rank : 802)	NC score	0.044075 (rank : 1196)
Query Neighborhood Hits	1243	Target Neighborhood Hits	549	Shared Neighborhood Hits	115
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

TAF4_HUMAN
θ value	0.125558 (rank : 803)	NC score	0.053614 (rank : 1146)
Query Neighborhood Hits	1243	Target Neighborhood Hits	687	Shared Neighborhood Hits	165
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

WASL_HUMAN
θ value	0.125558 (rank : 804)	NC score	0.045330 (rank : 1193)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	117
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

CO2A1_HUMAN
θ value	0.163984 (rank : 805)	NC score	0.038682 (rank : 1222)
Query Neighborhood Hits	1243	Target Neighborhood Hits	486	Shared Neighborhood Hits	141
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO2A1_MOUSE
θ value	0.163984 (rank : 806)	NC score	0.035240 (rank : 1244)
Query Neighborhood Hits	1243	Target Neighborhood Hits	483	Shared Neighborhood Hits	135
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO4A2_HUMAN
θ value	0.163984 (rank : 807)	NC score	0.041372 (rank : 1210)
Query Neighborhood Hits	1243	Target Neighborhood Hits	454	Shared Neighborhood Hits	142
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

IASPP_MOUSE
θ value	0.163984 (rank : 808)	NC score	0.097671 (rank : 969)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1024	Shared Neighborhood Hits	284
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MAPK2_HUMAN
θ value	0.163984 (rank : 809)	NC score	0.667631 (rank : 689)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	743
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	0.163984 (rank : 810)	NC score	0.664735 (rank : 694)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	739
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAST1_HUMAN
θ value	0.163984 (rank : 811)	NC score	0.657843 (rank : 707)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1146	Shared Neighborhood Hits	815
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0.163984 (rank : 812)	NC score	0.657488 (rank : 708)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1123	Shared Neighborhood Hits	813
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RP1L1_HUMAN
θ value	0.163984 (rank : 813)	NC score	0.034369 (rank : 1250)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1072	Shared Neighborhood Hits	199
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SFR14_MOUSE
θ value	0.163984 (rank : 814)	NC score	0.017433 (rank : 1385)
Query Neighborhood Hits	1243	Target Neighborhood Hits	238	Shared Neighborhood Hits	61
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

ARBK1_MOUSE
θ value	0.21417 (rank : 815)	NC score	0.650169 (rank : 719)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	746
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CAC1G_HUMAN
θ value	0.21417 (rank : 816)	NC score	0.021136 (rank : 1358)
Query Neighborhood Hits	1243	Target Neighborhood Hits	587	Shared Neighborhood Hits	185
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CO8A2_MOUSE
θ value	0.21417 (rank : 817)	NC score	0.029572 (rank : 1290)
Query Neighborhood Hits	1243	Target Neighborhood Hits	273	Shared Neighborhood Hits	90
SwissProt Accessions	P25318, Q68ED0, Q6KAQ4, Q6P1C4	Gene names	Col8a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

FOXJ2_HUMAN
θ value	0.21417 (rank : 818)	NC score	0.004855 (rank : 1502)
Query Neighborhood Hits	1243	Target Neighborhood Hits	239	Shared Neighborhood Hits	53
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

GUC2C_HUMAN
θ value	0.21417 (rank : 819)	NC score	0.727303 (rank : 454)
Query Neighborhood Hits	1243	Target Neighborhood Hits	624	Shared Neighborhood Hits	560
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

LATS2_HUMAN
θ value	0.21417 (rank : 820)	NC score	0.609758 (rank : 751)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	757
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	0.21417 (rank : 821)	NC score	0.611375 (rank : 749)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	759
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

NPHP4_MOUSE
θ value	0.21417 (rank : 822)	NC score	0.015205 (rank : 1404)
Query Neighborhood Hits	1243	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	P59240	Gene names	Nphp4
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

PKNX1_HUMAN
θ value	0.21417 (rank : 823)	NC score	0.005179 (rank : 1494)
Query Neighborhood Hits	1243	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	P55347, O00528, Q8IWT7	Gene names	PKNOX1, PREP1
Domain Architecture
Description	Homeobox protein PKNOX1 (PBX/knotted homeobox 1) (Homeobox protein PREP-1).

PKNX1_MOUSE
θ value	0.21417 (rank : 824)	NC score	0.005139 (rank : 1496)
Query Neighborhood Hits	1243	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	O70477	Gene names	Pknox1
Domain Architecture
Description	Homeobox protein PKNOX1 (PBX/knotted homeobox 1).

PTN23_MOUSE
θ value	0.21417 (rank : 825)	NC score	0.009875 (rank : 1448)
Query Neighborhood Hits	1243	Target Neighborhood Hits	726	Shared Neighborhood Hits	142
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

TM108_MOUSE
θ value	0.21417 (rank : 826)	NC score	0.027488 (rank : 1300)
Query Neighborhood Hits	1243	Target Neighborhood Hits	336	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

WNK2_HUMAN
θ value	0.21417 (rank : 827)	NC score	0.716936 (rank : 500)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1407	Shared Neighborhood Hits	858
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZN598_HUMAN
θ value	0.21417 (rank : 828)	NC score	0.018584 (rank : 1377)
Query Neighborhood Hits	1243	Target Neighborhood Hits	339	Shared Neighborhood Hits	63
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

ARBK1_HUMAN
θ value	0.279714 (rank : 829)	NC score	0.655159 (rank : 709)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	748
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ATBF1_HUMAN
θ value	0.279714 (rank : 830)	NC score	-0.011332 (rank : 1609)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1547	Shared Neighborhood Hits	129
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CSPG5_MOUSE
θ value	0.279714 (rank : 831)	NC score	0.023497 (rank : 1338)
Query Neighborhood Hits	1243	Target Neighborhood Hits	211	Shared Neighborhood Hits	64
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

FOG1_MOUSE
θ value	0.279714 (rank : 832)	NC score	-0.001498 (rank : 1574)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1237	Shared Neighborhood Hits	210
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HXD11_MOUSE
θ value	0.279714 (rank : 833)	NC score	-0.005219 (rank : 1591)
Query Neighborhood Hits	1243	Target Neighborhood Hits	376	Shared Neighborhood Hits	28
SwissProt Accessions	P23813	Gene names	Hoxd11, Hox-4.6, Hoxd-11
Domain Architecture
Description	Homeobox protein Hox-D11 (Hox-4.6) (Hox-5.5).

IL3B2_MOUSE
θ value	0.279714 (rank : 834)	NC score	0.041662 (rank : 1209)
Query Neighborhood Hits	1243	Target Neighborhood Hits	372	Shared Neighborhood Hits	149
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

MAP4_HUMAN
θ value	0.279714 (rank : 835)	NC score	0.025596 (rank : 1316)
Query Neighborhood Hits	1243	Target Neighborhood Hits	428	Shared Neighborhood Hits	108
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MARCS_MOUSE
θ value	0.279714 (rank : 836)	NC score	0.033103 (rank : 1263)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

NFH_MOUSE
θ value	0.279714 (rank : 837)	NC score	0.037364 (rank : 1234)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2247	Shared Neighborhood Hits	376
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PRR12_HUMAN
θ value	0.279714 (rank : 838)	NC score	0.049612 (rank : 1182)
Query Neighborhood Hits	1243	Target Neighborhood Hits	460	Shared Neighborhood Hits	124
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SCAR3_MOUSE
θ value	0.279714 (rank : 839)	NC score	0.024486 (rank : 1328)
Query Neighborhood Hits	1243	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C850, Q8C6N1	Gene names	Scara3
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3.

SYN1_HUMAN
θ value	0.279714 (rank : 840)	NC score	0.032143 (rank : 1269)
Query Neighborhood Hits	1243	Target Neighborhood Hits	419	Shared Neighborhood Hits	125
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

TGON2_HUMAN
θ value	0.279714 (rank : 841)	NC score	0.034735 (rank : 1246)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1037	Shared Neighborhood Hits	188
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TRI66_HUMAN
θ value	0.279714 (rank : 842)	NC score	0.012536 (rank : 1425)
Query Neighborhood Hits	1243	Target Neighborhood Hits	479	Shared Neighborhood Hits	94
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

AIM1_HUMAN
θ value	0.365318 (rank : 843)	NC score	0.011647 (rank : 1430)
Query Neighborhood Hits	1243	Target Neighborhood Hits	247	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

ARI1B_HUMAN
θ value	0.365318 (rank : 844)	NC score	0.033322 (rank : 1262)
Query Neighborhood Hits	1243	Target Neighborhood Hits	567	Shared Neighborhood Hits	159
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

ASPP1_MOUSE
θ value	0.365318 (rank : 845)	NC score	0.062202 (rank : 1083)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1244	Shared Neighborhood Hits	235
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ATBF1_MOUSE
θ value	0.365318 (rank : 846)	NC score	-0.005419 (rank : 1592)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1841	Shared Neighborhood Hits	187
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ATX2_HUMAN
θ value	0.365318 (rank : 847)	NC score	0.017128 (rank : 1387)
Query Neighborhood Hits	1243	Target Neighborhood Hits	375	Shared Neighborhood Hits	80
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

BAZ2A_HUMAN
θ value	0.365318 (rank : 848)	NC score	0.021660 (rank : 1352)
Query Neighborhood Hits	1243	Target Neighborhood Hits	780	Shared Neighborhood Hits	162
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BSN_MOUSE
θ value	0.365318 (rank : 849)	NC score	0.070809 (rank : 1043)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2057	Shared Neighborhood Hits	413
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CNOT3_MOUSE
θ value	0.365318 (rank : 850)	NC score	0.030727 (rank : 1281)
Query Neighborhood Hits	1243	Target Neighborhood Hits	504	Shared Neighborhood Hits	105
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO8A2_HUMAN
θ value	0.365318 (rank : 851)	NC score	0.030630 (rank : 1283)
Query Neighborhood Hits	1243	Target Neighborhood Hits	299	Shared Neighborhood Hits	89
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

COBA2_HUMAN
θ value	0.365318 (rank : 852)	NC score	0.036165 (rank : 1240)
Query Neighborhood Hits	1243	Target Neighborhood Hits	408	Shared Neighborhood Hits	113
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CRSP2_HUMAN
θ value	0.365318 (rank : 853)	NC score	0.036585 (rank : 1236)
Query Neighborhood Hits	1243	Target Neighborhood Hits	380	Shared Neighborhood Hits	138
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

FMOD_HUMAN
θ value	0.365318 (rank : 854)	NC score	-0.007186 (rank : 1599)
Query Neighborhood Hits	1243	Target Neighborhood Hits	283	Shared Neighborhood Hits	9
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

IL3RB_MOUSE
θ value	0.365318 (rank : 855)	NC score	0.039074 (rank : 1219)
Query Neighborhood Hits	1243	Target Neighborhood Hits	355	Shared Neighborhood Hits	139
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

MAST2_HUMAN
θ value	0.365318 (rank : 856)	NC score	0.659994 (rank : 703)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1189	Shared Neighborhood Hits	820
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	0.365318 (rank : 857)	NC score	0.660790 (rank : 702)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1110	Shared Neighborhood Hits	794
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ROBO3_HUMAN
θ value	0.365318 (rank : 858)	NC score	0.115752 (rank : 917)
Query Neighborhood Hits	1243	Target Neighborhood Hits	570	Shared Neighborhood Hits	122
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

SYN3_HUMAN
θ value	0.365318 (rank : 859)	NC score	0.020168 (rank : 1363)
Query Neighborhood Hits	1243	Target Neighborhood Hits	203	Shared Neighborhood Hits	63
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

WASF2_HUMAN
θ value	0.365318 (rank : 860)	NC score	0.030948 (rank : 1279)
Query Neighborhood Hits	1243	Target Neighborhood Hits	280	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

3BP1_HUMAN
θ value	0.47712 (rank : 861)	NC score	0.014423 (rank : 1412)
Query Neighborhood Hits	1243	Target Neighborhood Hits	376	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

COBA1_HUMAN
θ value	0.47712 (rank : 862)	NC score	0.034221 (rank : 1253)
Query Neighborhood Hits	1243	Target Neighborhood Hits	491	Shared Neighborhood Hits	135
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COEA1_HUMAN
θ value	0.47712 (rank : 863)	NC score	0.034349 (rank : 1251)
Query Neighborhood Hits	1243	Target Neighborhood Hits	427	Shared Neighborhood Hits	107
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

CSPG3_HUMAN
θ value	0.47712 (rank : 864)	NC score	0.005818 (rank : 1487)
Query Neighborhood Hits	1243	Target Neighborhood Hits	676	Shared Neighborhood Hits	88
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CSTFT_MOUSE
θ value	0.47712 (rank : 865)	NC score	0.006135 (rank : 1483)
Query Neighborhood Hits	1243	Target Neighborhood Hits	356	Shared Neighborhood Hits	82
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

DVL2_HUMAN
θ value	0.47712 (rank : 866)	NC score	0.002628 (rank : 1524)
Query Neighborhood Hits	1243	Target Neighborhood Hits	223	Shared Neighborhood Hits	36
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

FMOD_MOUSE
θ value	0.47712 (rank : 867)	NC score	-0.007352 (rank : 1600)
Query Neighborhood Hits	1243	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

FOXC1_HUMAN
θ value	0.47712 (rank : 868)	NC score	0.003932 (rank : 1512)
Query Neighborhood Hits	1243	Target Neighborhood Hits	208	Shared Neighborhood Hits	51
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

GRIN1_HUMAN
θ value	0.47712 (rank : 869)	NC score	0.049808 (rank : 1181)
Query Neighborhood Hits	1243	Target Neighborhood Hits	681	Shared Neighborhood Hits	209
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

K0460_HUMAN
θ value	0.47712 (rank : 870)	NC score	0.018010 (rank : 1382)
Query Neighborhood Hits	1243	Target Neighborhood Hits	357	Shared Neighborhood Hits	65
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

KC1A_HUMAN
θ value	0.47712 (rank : 871)	NC score	0.509749 (rank : 804)
Query Neighborhood Hits	1243	Target Neighborhood Hits	728	Shared Neighborhood Hits	659
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	0.47712 (rank : 872)	NC score	0.509749 (rank : 805)
Query Neighborhood Hits	1243	Target Neighborhood Hits	728	Shared Neighborhood Hits	659
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KCNQ2_HUMAN
θ value	0.47712 (rank : 873)	NC score	-0.000236 (rank : 1563)
Query Neighborhood Hits	1243	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

MEGF9_MOUSE
θ value	0.47712 (rank : 874)	NC score	0.034411 (rank : 1249)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	205
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

PIM1_HUMAN
θ value	0.47712 (rank : 875)	NC score	0.652014 (rank : 714)
Query Neighborhood Hits	1243	Target Neighborhood Hits	797	Shared Neighborhood Hits	715
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_HUMAN
θ value	0.47712 (rank : 876)	NC score	0.679354 (rank : 661)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	732
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PRP2_MOUSE
θ value	0.47712 (rank : 877)	NC score	0.050307 (rank : 1176)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	108
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SMR3B_HUMAN
θ value	0.47712 (rank : 878)	NC score	0.032241 (rank : 1266)
Query Neighborhood Hits	1243	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	P02814, Q9UBN0, Q9UCT0	Gene names	SMR3B, PBII, PROL3
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog B precursor (Proline-rich protein 3) (Proline-rich peptide P-B) [Contains: Peptide P-A; Peptide D1A].

TB182_HUMAN
θ value	0.47712 (rank : 879)	NC score	0.030633 (rank : 1282)
Query Neighborhood Hits	1243	Target Neighborhood Hits	414	Shared Neighborhood Hits	104
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TM16H_HUMAN
θ value	0.47712 (rank : 880)	NC score	0.014877 (rank : 1407)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

TRI47_HUMAN
θ value	0.47712 (rank : 881)	NC score	-0.001969 (rank : 1577)
Query Neighborhood Hits	1243	Target Neighborhood Hits	286	Shared Neighborhood Hits	22
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

VRK3_HUMAN
θ value	0.47712 (rank : 882)	NC score	0.189557 (rank : 859)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	289
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WASF4_HUMAN
θ value	0.47712 (rank : 883)	NC score	0.034069 (rank : 1254)
Query Neighborhood Hits	1243	Target Neighborhood Hits	282	Shared Neighborhood Hits	102
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

WASP_MOUSE
θ value	0.47712 (rank : 884)	NC score	0.037185 (rank : 1235)
Query Neighborhood Hits	1243	Target Neighborhood Hits	223	Shared Neighborhood Hits	88
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

ZFHX2_HUMAN
θ value	0.47712 (rank : 885)	NC score	-0.004481 (rank : 1589)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1178	Shared Neighborhood Hits	130
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

ADRB1_MOUSE
θ value	0.62314 (rank : 886)	NC score	-0.022426 (rank : 1624)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	4
SwissProt Accessions	P34971	Gene names	Adrb1, Adrb1r
Domain Architecture
Description	Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 adrenoreceptor).

CNOT4_MOUSE
θ value	0.62314 (rank : 887)	NC score	0.015924 (rank : 1397)
Query Neighborhood Hits	1243	Target Neighborhood Hits	277	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CO8A1_HUMAN
θ value	0.62314 (rank : 888)	NC score	0.026227 (rank : 1310)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	78
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

CO9A2_MOUSE
θ value	0.62314 (rank : 889)	NC score	0.034465 (rank : 1248)
Query Neighborhood Hits	1243	Target Neighborhood Hits	279	Shared Neighborhood Hits	86
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

GAK10_HUMAN
θ value	0.62314 (rank : 890)	NC score	0.022806 (rank : 1345)
Query Neighborhood Hits	1243	Target Neighborhood Hits	289	Shared Neighborhood Hits	107
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

LDB3_MOUSE
θ value	0.62314 (rank : 891)	NC score	0.013315 (rank : 1422)
Query Neighborhood Hits	1243	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

MILK1_HUMAN
θ value	0.62314 (rank : 892)	NC score	0.018393 (rank : 1379)
Query Neighborhood Hits	1243	Target Neighborhood Hits	427	Shared Neighborhood Hits	99
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NCOR2_HUMAN
θ value	0.62314 (rank : 893)	NC score	0.035110 (rank : 1245)
Query Neighborhood Hits	1243	Target Neighborhood Hits	870	Shared Neighborhood Hits	198
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NLK_HUMAN
θ value	0.62314 (rank : 894)	NC score	0.711960 (rank : 510)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	754
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	0.62314 (rank : 895)	NC score	0.712044 (rank : 509)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	754
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

PELP1_HUMAN
θ value	0.62314 (rank : 896)	NC score	0.023715 (rank : 1336)
Query Neighborhood Hits	1243	Target Neighborhood Hits	596	Shared Neighborhood Hits	101
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PPRB_MOUSE
θ value	0.62314 (rank : 897)	NC score	0.023241 (rank : 1341)
Query Neighborhood Hits	1243	Target Neighborhood Hits	354	Shared Neighborhood Hits	75
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

PTN23_HUMAN
θ value	0.62314 (rank : 898)	NC score	0.009497 (rank : 1452)
Query Neighborhood Hits	1243	Target Neighborhood Hits	646	Shared Neighborhood Hits	106
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RTN4R_HUMAN
θ value	0.62314 (rank : 899)	NC score	-0.006663 (rank : 1596)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RXRA_HUMAN
θ value	0.62314 (rank : 900)	NC score	-0.004759 (rank : 1590)
Query Neighborhood Hits	1243	Target Neighborhood Hits	223	Shared Neighborhood Hits	44
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

SMR1_MOUSE
θ value	0.62314 (rank : 901)	NC score	0.027108 (rank : 1305)
Query Neighborhood Hits	1243	Target Neighborhood Hits	103	Shared Neighborhood Hits	41
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

SPR1B_MOUSE
θ value	0.62314 (rank : 902)	NC score	0.038218 (rank : 1226)
Query Neighborhood Hits	1243	Target Neighborhood Hits	395	Shared Neighborhood Hits	150
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

BRD8_MOUSE
θ value	0.813845 (rank : 903)	NC score	0.019511 (rank : 1368)
Query Neighborhood Hits	1243	Target Neighborhood Hits	422	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

BSN_HUMAN
θ value	0.813845 (rank : 904)	NC score	0.057624 (rank : 1112)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1537	Shared Neighborhood Hits	318
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CO4A1_MOUSE
θ value	0.813845 (rank : 905)	NC score	0.038664 (rank : 1223)
Query Neighborhood Hits	1243	Target Neighborhood Hits	450	Shared Neighborhood Hits	138
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO4A3_HUMAN
θ value	0.813845 (rank : 906)	NC score	0.038518 (rank : 1224)
Query Neighborhood Hits	1243	Target Neighborhood Hits	421	Shared Neighborhood Hits	120
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CO4A5_HUMAN
θ value	0.813845 (rank : 907)	NC score	0.033790 (rank : 1258)
Query Neighborhood Hits	1243	Target Neighborhood Hits	383	Shared Neighborhood Hits	109
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

COBA1_MOUSE
θ value	0.813845 (rank : 908)	NC score	0.033719 (rank : 1260)
Query Neighborhood Hits	1243	Target Neighborhood Hits	487	Shared Neighborhood Hits	135
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COEA1_MOUSE
θ value	0.813845 (rank : 909)	NC score	0.027482 (rank : 1301)
Query Neighborhood Hits	1243	Target Neighborhood Hits	402	Shared Neighborhood Hits	94
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

DIAP3_MOUSE
θ value	0.813845 (rank : 910)	NC score	0.015895 (rank : 1398)
Query Neighborhood Hits	1243	Target Neighborhood Hits	221	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z207	Gene names	Diaph3, Diap3
Domain Architecture
Description	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2).

ENAH_HUMAN
θ value	0.813845 (rank : 911)	NC score	0.031487 (rank : 1275)
Query Neighborhood Hits	1243	Target Neighborhood Hits	784	Shared Neighborhood Hits	129
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

FMN2_MOUSE
θ value	0.813845 (rank : 912)	NC score	0.026479 (rank : 1309)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	103
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

GAK11_HUMAN
θ value	0.813845 (rank : 913)	NC score	0.025093 (rank : 1318)
Query Neighborhood Hits	1243	Target Neighborhood Hits	409	Shared Neighborhood Hits	158
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
θ value	0.813845 (rank : 914)	NC score	0.024922 (rank : 1321)
Query Neighborhood Hits	1243	Target Neighborhood Hits	406	Shared Neighborhood Hits	156
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	0.813845 (rank : 915)	NC score	0.024885 (rank : 1322)
Query Neighborhood Hits	1243	Target Neighborhood Hits	415	Shared Neighborhood Hits	159
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	0.813845 (rank : 916)	NC score	0.025685 (rank : 1315)
Query Neighborhood Hits	1243	Target Neighborhood Hits	429	Shared Neighborhood Hits	159
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK6_HUMAN
θ value	0.813845 (rank : 917)	NC score	0.025368 (rank : 1317)
Query Neighborhood Hits	1243	Target Neighborhood Hits	392	Shared Neighborhood Hits	152
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK8_HUMAN
θ value	0.813845 (rank : 918)	NC score	0.015714 (rank : 1399)
Query Neighborhood Hits	1243	Target Neighborhood Hits	145	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GCFC_HUMAN
θ value	0.813845 (rank : 919)	NC score	0.011346 (rank : 1434)
Query Neighborhood Hits	1243	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5B6, Q9NYQ0	Gene names	GCFC, C21orf66
Domain Architecture	No domain graphic available
Description	GC-rich sequence DNA-binding factor homolog.

IASPP_HUMAN
θ value	0.813845 (rank : 920)	NC score	0.077345 (rank : 1025)
Query Neighborhood Hits	1243	Target Neighborhood Hits	688	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LR37A_HUMAN
θ value	0.813845 (rank : 921)	NC score	0.014102 (rank : 1415)
Query Neighborhood Hits	1243	Target Neighborhood Hits	720	Shared Neighborhood Hits	129
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MAGD4_HUMAN
θ value	0.813845 (rank : 922)	NC score	0.006961 (rank : 1474)
Query Neighborhood Hits	1243	Target Neighborhood Hits	338	Shared Neighborhood Hits	94
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

RERE_HUMAN
θ value	0.813845 (rank : 923)	NC score	0.029697 (rank : 1288)
Query Neighborhood Hits	1243	Target Neighborhood Hits	779	Shared Neighborhood Hits	173
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

REXO1_HUMAN
θ value	0.813845 (rank : 924)	NC score	0.015533 (rank : 1401)
Query Neighborhood Hits	1243	Target Neighborhood Hits	242	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

RUSC2_MOUSE
θ value	0.813845 (rank : 925)	NC score	0.028338 (rank : 1295)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	95
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

T22D2_HUMAN
θ value	0.813845 (rank : 926)	NC score	0.025899 (rank : 1314)
Query Neighborhood Hits	1243	Target Neighborhood Hits	250	Shared Neighborhood Hits	76
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

ARBK2_HUMAN
θ value	1.06291 (rank : 927)	NC score	0.644406 (rank : 724)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	746
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

BAT2_MOUSE
θ value	1.06291 (rank : 928)	NC score	0.039050 (rank : 1220)
Query Neighborhood Hits	1243	Target Neighborhood Hits	947	Shared Neighborhood Hits	255
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CENG1_HUMAN
θ value	1.06291 (rank : 929)	NC score	0.006274 (rank : 1481)
Query Neighborhood Hits	1243	Target Neighborhood Hits	544	Shared Neighborhood Hits	69
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CSKI2_HUMAN
θ value	1.06291 (rank : 930)	NC score	0.058161 (rank : 1108)
Query Neighborhood Hits	1243	Target Neighborhood Hits	747	Shared Neighborhood Hits	149
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPN3_HUMAN
θ value	1.06291 (rank : 931)	NC score	0.015989 (rank : 1396)
Query Neighborhood Hits	1243	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

FOXJ2_MOUSE
θ value	1.06291 (rank : 932)	NC score	0.002653 (rank : 1523)
Query Neighborhood Hits	1243	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ES18	Gene names	Foxj2, Fhx
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

GAK12_HUMAN
θ value	1.06291 (rank : 933)	NC score	0.022522 (rank : 1346)
Query Neighborhood Hits	1243	Target Neighborhood Hits	374	Shared Neighborhood Hits	142
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GORS2_MOUSE
θ value	1.06291 (rank : 934)	NC score	0.010871 (rank : 1442)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

HXA4_MOUSE
θ value	1.06291 (rank : 935)	NC score	-0.007140 (rank : 1598)
Query Neighborhood Hits	1243	Target Neighborhood Hits	379	Shared Neighborhood Hits	30
SwissProt Accessions	P06798, Q61684, Q64388, Q8BPE6	Gene names	Hoxa4, Hox-1.4, Hoxa-4
Domain Architecture
Description	Homeobox protein Hox-A4 (Hox-1.4) (Homeobox protein MH-3).

MICA1_HUMAN
θ value	1.06291 (rank : 936)	NC score	0.010355 (rank : 1443)
Query Neighborhood Hits	1243	Target Neighborhood Hits	279	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MYO15_HUMAN
θ value	1.06291 (rank : 937)	NC score	0.020253 (rank : 1361)
Query Neighborhood Hits	1243	Target Neighborhood Hits	671	Shared Neighborhood Hits	205
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NFRKB_MOUSE
θ value	1.06291 (rank : 938)	NC score	0.025010 (rank : 1319)
Query Neighborhood Hits	1243	Target Neighborhood Hits	393	Shared Neighborhood Hits	115
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

PHLB1_MOUSE
θ value	1.06291 (rank : 939)	NC score	0.011827 (rank : 1429)
Query Neighborhood Hits	1243	Target Neighborhood Hits	678	Shared Neighborhood Hits	99
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RP3A_MOUSE
θ value	1.06291 (rank : 940)	NC score	0.028590 (rank : 1294)
Query Neighborhood Hits	1243	Target Neighborhood Hits	510	Shared Neighborhood Hits	148
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SFR15_HUMAN
θ value	1.06291 (rank : 941)	NC score	0.021622 (rank : 1353)
Query Neighborhood Hits	1243	Target Neighborhood Hits	368	Shared Neighborhood Hits	87
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

TBX21_HUMAN
θ value	1.06291 (rank : 942)	NC score	0.005635 (rank : 1489)
Query Neighborhood Hits	1243	Target Neighborhood Hits	146	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

WASF1_HUMAN
θ value	1.06291 (rank : 943)	NC score	0.027344 (rank : 1303)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	75
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASIP_HUMAN
θ value	1.06291 (rank : 944)	NC score	0.046311 (rank : 1189)
Query Neighborhood Hits	1243	Target Neighborhood Hits	458	Shared Neighborhood Hits	130
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

YLPM1_MOUSE
θ value	1.06291 (rank : 945)	NC score	0.027220 (rank : 1304)
Query Neighborhood Hits	1243	Target Neighborhood Hits	505	Shared Neighborhood Hits	118
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

CHKA_HUMAN
θ value	1.38821 (rank : 946)	NC score	0.005041 (rank : 1497)
Query Neighborhood Hits	1243	Target Neighborhood Hits	25	Shared Neighborhood Hits	7
SwissProt Accessions	P35790, Q8NE29	Gene names	CHKA, CHK, CKI
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

CIC_HUMAN
θ value	1.38821 (rank : 947)	NC score	0.036581 (rank : 1237)
Query Neighborhood Hits	1243	Target Neighborhood Hits	992	Shared Neighborhood Hits	290
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CING_HUMAN
θ value	1.38821 (rank : 948)	NC score	0.005219 (rank : 1493)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1275	Shared Neighborhood Hits	111
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CN032_MOUSE
θ value	1.38821 (rank : 949)	NC score	0.032786 (rank : 1265)
Query Neighborhood Hits	1243	Target Neighborhood Hits	233	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

CN155_HUMAN
θ value	1.38821 (rank : 950)	NC score	0.032957 (rank : 1264)
Query Neighborhood Hits	1243	Target Neighborhood Hits	385	Shared Neighborhood Hits	83
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CSKI2_MOUSE
θ value	1.38821 (rank : 951)	NC score	0.061296 (rank : 1089)
Query Neighborhood Hits	1243	Target Neighborhood Hits	812	Shared Neighborhood Hits	193
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CT055_HUMAN
θ value	1.38821 (rank : 952)	NC score	0.012151 (rank : 1426)
Query Neighborhood Hits	1243	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ89	Gene names	C20orf55
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55.

FMN2_HUMAN
θ value	1.38821 (rank : 953)	NC score	0.031048 (rank : 1277)
Query Neighborhood Hits	1243	Target Neighborhood Hits	484	Shared Neighborhood Hits	124
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FMNL_HUMAN
θ value	1.38821 (rank : 954)	NC score	0.028284 (rank : 1296)
Query Neighborhood Hits	1243	Target Neighborhood Hits	529	Shared Neighborhood Hits	120
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GGN_MOUSE
θ value	1.38821 (rank : 955)	NC score	0.035961 (rank : 1241)
Query Neighborhood Hits	1243	Target Neighborhood Hits	311	Shared Neighborhood Hits	101
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GP152_MOUSE
θ value	1.38821 (rank : 956)	NC score	-0.001986 (rank : 1578)
Query Neighborhood Hits	1243	Target Neighborhood Hits	607	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

HCN2_HUMAN
θ value	1.38821 (rank : 957)	NC score	0.012605 (rank : 1423)
Query Neighborhood Hits	1243	Target Neighborhood Hits	369	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

IRS2_MOUSE
θ value	1.38821 (rank : 958)	NC score	0.020543 (rank : 1359)
Query Neighborhood Hits	1243	Target Neighborhood Hits	248	Shared Neighborhood Hits	73
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

MAP1A_HUMAN
θ value	1.38821 (rank : 959)	NC score	0.031518 (rank : 1274)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1626	Shared Neighborhood Hits	277
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

OSBL5_HUMAN
θ value	1.38821 (rank : 960)	NC score	0.004575 (rank : 1506)
Query Neighborhood Hits	1243	Target Neighborhood Hits	117	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

PGRP2_HUMAN
θ value	1.38821 (rank : 961)	NC score	0.006110 (rank : 1484)
Query Neighborhood Hits	1243	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PD5, Q96N74, Q9UC60	Gene names	PGLYRP2, PGLYRPL, PGRPL
Domain Architecture
Description	N-acetylmuramoyl-L-alanine amidase precursor (EC 3.5.1.28) (Peptidoglycan recognition protein long) (PGRP-L) (Peptidoglycan recognition protein 2).

PHLB1_HUMAN
θ value	1.38821 (rank : 962)	NC score	0.022079 (rank : 1348)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1038	Shared Neighborhood Hits	181
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RBM12_MOUSE
θ value	1.38821 (rank : 963)	NC score	0.021468 (rank : 1354)
Query Neighborhood Hits	1243	Target Neighborhood Hits	313	Shared Neighborhood Hits	85
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

TREF1_MOUSE
θ value	1.38821 (rank : 964)	NC score	0.004433 (rank : 1507)
Query Neighborhood Hits	1243	Target Neighborhood Hits	682	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

TRI66_MOUSE
θ value	1.38821 (rank : 965)	NC score	0.015335 (rank : 1402)
Query Neighborhood Hits	1243	Target Neighborhood Hits	491	Shared Neighborhood Hits	100
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

WASF2_MOUSE
θ value	1.38821 (rank : 966)	NC score	0.031558 (rank : 1273)
Query Neighborhood Hits	1243	Target Neighborhood Hits	315	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ZC3H3_MOUSE
θ value	1.38821 (rank : 967)	NC score	0.008910 (rank : 1456)
Query Neighborhood Hits	1243	Target Neighborhood Hits	188	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

ARVC_MOUSE
θ value	1.81305 (rank : 968)	NC score	0.000930 (rank : 1550)
Query Neighborhood Hits	1243	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

ATX7_HUMAN
θ value	1.81305 (rank : 969)	NC score	0.022985 (rank : 1344)
Query Neighborhood Hits	1243	Target Neighborhood Hits	351	Shared Neighborhood Hits	115
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

BRD4_MOUSE
θ value	1.81305 (rank : 970)	NC score	0.018699 (rank : 1373)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	147
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CD5_MOUSE
θ value	1.81305 (rank : 971)	NC score	0.004375 (rank : 1508)
Query Neighborhood Hits	1243	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

DAAM1_HUMAN
θ value	1.81305 (rank : 972)	NC score	0.015284 (rank : 1403)
Query Neighborhood Hits	1243	Target Neighborhood Hits	483	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

DAAM1_MOUSE
θ value	1.81305 (rank : 973)	NC score	0.014546 (rank : 1411)
Query Neighborhood Hits	1243	Target Neighborhood Hits	443	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BPM0, Q80Y68, Q9CQQ2	Gene names	Daam1
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

DUET_HUMAN
θ value	1.81305 (rank : 974)	NC score	0.601844 (rank : 759)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1220	Shared Neighborhood Hits	751
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DUS8_MOUSE
θ value	1.81305 (rank : 975)	NC score	0.001898 (rank : 1534)
Query Neighborhood Hits	1243	Target Neighborhood Hits	119	Shared Neighborhood Hits	19
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

EMID1_MOUSE
θ value	1.81305 (rank : 976)	NC score	0.024509 (rank : 1327)
Query Neighborhood Hits	1243	Target Neighborhood Hits	230	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VF5	Gene names	Emid1, Emu1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

F5006_HUMAN
θ value	1.81305 (rank : 977)	NC score	0.628660 (rank : 733)
Query Neighborhood Hits	1243	Target Neighborhood Hits	794	Shared Neighborhood Hits	722
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FOXL1_HUMAN
θ value	1.81305 (rank : 978)	NC score	-0.000305 (rank : 1565)
Query Neighborhood Hits	1243	Target Neighborhood Hits	114	Shared Neighborhood Hits	19
SwissProt Accessions	Q12952, Q9H242	Gene names	FOXL1, FKHL11, FREAC7
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead- related transcription factor 7) (FREAC-7).

GLI1_MOUSE
θ value	1.81305 (rank : 979)	NC score	-0.020026 (rank : 1616)
Query Neighborhood Hits	1243	Target Neighborhood Hits	785	Shared Neighborhood Hits	49
SwissProt Accessions	P47806, Q9QYK1	Gene names	Gli1, Gli
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene homolog).

HIPK1_HUMAN
θ value	1.81305 (rank : 980)	NC score	0.604083 (rank : 757)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	713
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	1.81305 (rank : 981)	NC score	0.603944 (rank : 758)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	713
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HXA3_HUMAN
θ value	1.81305 (rank : 982)	NC score	0.000171 (rank : 1559)
Query Neighborhood Hits	1243	Target Neighborhood Hits	535	Shared Neighborhood Hits	87
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

HXC12_MOUSE
θ value	1.81305 (rank : 983)	NC score	-0.008057 (rank : 1603)
Query Neighborhood Hits	1243	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K5B8	Gene names	Hoxc12, Hox-3.8, Hoxc-12
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C12 (Hox-3.8).

LOXL2_MOUSE
θ value	1.81305 (rank : 984)	NC score	-0.001335 (rank : 1570)
Query Neighborhood Hits	1243	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

MILK1_MOUSE
θ value	1.81305 (rank : 985)	NC score	0.031477 (rank : 1276)
Query Neighborhood Hits	1243	Target Neighborhood Hits	788	Shared Neighborhood Hits	215
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PINK1_HUMAN
θ value	1.81305 (rank : 986)	NC score	0.615019 (rank : 748)
Query Neighborhood Hits	1243	Target Neighborhood Hits	741	Shared Neighborhood Hits	681
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

SET1A_HUMAN
θ value	1.81305 (rank : 987)	NC score	0.023329 (rank : 1339)
Query Neighborhood Hits	1243	Target Neighborhood Hits	690	Shared Neighborhood Hits	130
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SF3B4_HUMAN
θ value	1.81305 (rank : 988)	NC score	0.007154 (rank : 1472)
Query Neighborhood Hits	1243	Target Neighborhood Hits	445	Shared Neighborhood Hits	91
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

SRRM2_HUMAN
θ value	1.81305 (rank : 989)	NC score	0.045783 (rank : 1191)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1296	Shared Neighborhood Hits	230
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

X3CL1_HUMAN
θ value	1.81305 (rank : 990)	NC score	0.010032 (rank : 1445)
Query Neighborhood Hits	1243	Target Neighborhood Hits	152	Shared Neighborhood Hits	38
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

ZKSC1_MOUSE
θ value	1.81305 (rank : 991)	NC score	-0.022336 (rank : 1623)
Query Neighborhood Hits	1243	Target Neighborhood Hits	755	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGS3, Q7TS88, Q8BJ55, Q9CRN6	Gene names	Zkscan1
Domain Architecture	No domain graphic available
Description	Zinc finger with KRAB and SCAN domain-containing protein 1.

ZN687_HUMAN
θ value	1.81305 (rank : 992)	NC score	-0.001361 (rank : 1571)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1244	Shared Neighborhood Hits	245
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ZN692_HUMAN
θ value	1.81305 (rank : 993)	NC score	-0.020982 (rank : 1619)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

CLSPN_MOUSE
θ value	2.36792 (rank : 994)	NC score	0.006252 (rank : 1482)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	34
SwissProt Accessions	Q80YR7, Q69GM2	Gene names	Clspn
Domain Architecture	No domain graphic available
Description	Claspin.

COGA1_HUMAN
θ value	2.36792 (rank : 995)	NC score	0.035844 (rank : 1242)
Query Neighborhood Hits	1243	Target Neighborhood Hits	345	Shared Neighborhood Hits	107
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

COIA1_MOUSE
θ value	2.36792 (rank : 996)	NC score	0.033852 (rank : 1257)
Query Neighborhood Hits	1243	Target Neighborhood Hits	481	Shared Neighborhood Hits	132
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CSTFT_HUMAN
θ value	2.36792 (rank : 997)	NC score	0.000428 (rank : 1557)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

CUTL2_HUMAN
θ value	2.36792 (rank : 998)	NC score	0.011281 (rank : 1435)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	137
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

DIAP1_MOUSE
θ value	2.36792 (rank : 999)	NC score	0.018887 (rank : 1372)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	126
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

DLL3_MOUSE
θ value	2.36792 (rank : 1000)	NC score	0.001742 (rank : 1539)
Query Neighborhood Hits	1243	Target Neighborhood Hits	399	Shared Neighborhood Hits	19
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

DYN2_MOUSE
θ value	2.36792 (rank : 1001)	NC score	0.009534 (rank : 1451)
Query Neighborhood Hits	1243	Target Neighborhood Hits	104	Shared Neighborhood Hits	24
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

EP400_HUMAN
θ value	2.36792 (rank : 1002)	NC score	0.008709 (rank : 1460)
Query Neighborhood Hits	1243	Target Neighborhood Hits	556	Shared Neighborhood Hits	109
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

FIGN_HUMAN
θ value	2.36792 (rank : 1003)	NC score	0.001400 (rank : 1544)
Query Neighborhood Hits	1243	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

HCN4_MOUSE
θ value	2.36792 (rank : 1004)	NC score	0.013492 (rank : 1421)
Query Neighborhood Hits	1243	Target Neighborhood Hits	284	Shared Neighborhood Hits	89
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HIPK2_HUMAN
θ value	2.36792 (rank : 1005)	NC score	0.597522 (rank : 764)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	712
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	2.36792 (rank : 1006)	NC score	0.597449 (rank : 765)
Query Neighborhood Hits	1243	Target Neighborhood Hits	871	Shared Neighborhood Hits	720
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HXB3_HUMAN
θ value	2.36792 (rank : 1007)	NC score	0.001167 (rank : 1547)
Query Neighborhood Hits	1243	Target Neighborhood Hits	559	Shared Neighborhood Hits	127
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

IF4B_HUMAN
θ value	2.36792 (rank : 1008)	NC score	0.019946 (rank : 1364)
Query Neighborhood Hits	1243	Target Neighborhood Hits	417	Shared Neighborhood Hits	111
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

KS6C1_MOUSE
θ value	2.36792 (rank : 1009)	NC score	0.457985 (rank : 820)
Query Neighborhood Hits	1243	Target Neighborhood Hits	700	Shared Neighborhood Hits	588
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LRC47_MOUSE
θ value	2.36792 (rank : 1010)	NC score	-0.007527 (rank : 1601)
Query Neighborhood Hits	1243	Target Neighborhood Hits	299	Shared Neighborhood Hits	9
SwissProt Accessions	Q505F5, Q3U380, Q6ZPW2, Q9CUZ0	Gene names	Lrrc47, Kiaa1185
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 47.

MNAB_MOUSE
θ value	2.36792 (rank : 1011)	NC score	0.006469 (rank : 1479)
Query Neighborhood Hits	1243	Target Neighborhood Hits	231	Shared Neighborhood Hits	39
SwissProt Accessions	P0C090	Gene names	Mnab
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein.

NCOA2_MOUSE
θ value	2.36792 (rank : 1012)	NC score	0.011395 (rank : 1433)
Query Neighborhood Hits	1243	Target Neighborhood Hits	281	Shared Neighborhood Hits	93
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

PABP2_HUMAN
θ value	2.36792 (rank : 1013)	NC score	0.001776 (rank : 1538)
Query Neighborhood Hits	1243	Target Neighborhood Hits	212	Shared Neighborhood Hits	26
SwissProt Accessions	Q86U42, O43484	Gene names	PABPN1, PAB2, PABP2
Domain Architecture
Description	Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (Poly(A)- binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Nuclear poly(A)-binding protein 1).

PRP5_HUMAN
θ value	2.36792 (rank : 1014)	NC score	0.037681 (rank : 1231)
Query Neighborhood Hits	1243	Target Neighborhood Hits	108	Shared Neighborhood Hits	45
SwissProt Accessions	P04281	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide IB-1.

SASH1_MOUSE
θ value	2.36792 (rank : 1015)	NC score	0.047060 (rank : 1187)
Query Neighborhood Hits	1243	Target Neighborhood Hits	263	Shared Neighborhood Hits	83
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SNPC4_HUMAN
θ value	2.36792 (rank : 1016)	NC score	0.043425 (rank : 1199)
Query Neighborhood Hits	1243	Target Neighborhood Hits	589	Shared Neighborhood Hits	215
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

TACC1_MOUSE
θ value	2.36792 (rank : 1017)	NC score	0.004772 (rank : 1504)
Query Neighborhood Hits	1243	Target Neighborhood Hits	667	Shared Neighborhood Hits	67
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TM119_HUMAN
θ value	2.36792 (rank : 1018)	NC score	0.018446 (rank : 1378)
Query Neighborhood Hits	1243	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q4V9L6, Q6UXE5, Q8N2F5	Gene names	TMEM119
Domain Architecture	No domain graphic available
Description	Transmembrane protein 119 precursor.

VRK2_HUMAN
θ value	2.36792 (rank : 1019)	NC score	0.378009 (rank : 827)
Query Neighborhood Hits	1243	Target Neighborhood Hits	582	Shared Neighborhood Hits	523
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

WASIP_MOUSE
θ value	2.36792 (rank : 1020)	NC score	0.046229 (rank : 1190)
Query Neighborhood Hits	1243	Target Neighborhood Hits	392	Shared Neighborhood Hits	115
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ZN318_HUMAN
θ value	2.36792 (rank : 1021)	NC score	0.011116 (rank : 1436)
Query Neighborhood Hits	1243	Target Neighborhood Hits	497	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ZN687_MOUSE
θ value	2.36792 (rank : 1022)	NC score	-0.011855 (rank : 1610)
Query Neighborhood Hits	1243	Target Neighborhood Hits	913	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

AKP8L_MOUSE
θ value	3.0926 (rank : 1023)	NC score	0.003080 (rank : 1520)
Query Neighborhood Hits	1243	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R0L7	Gene names	Akap8l, Nakap95
Domain Architecture
Description	A-kinase anchor protein 8-like (AKAP8-like protein) (Neighbor of A- kinase-anchoring protein 95) (Neighbor of AKAP95).

ANR47_HUMAN
θ value	3.0926 (rank : 1024)	NC score	0.009187 (rank : 1453)
Query Neighborhood Hits	1243	Target Neighborhood Hits	369	Shared Neighborhood Hits	42
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASXL1_HUMAN
θ value	3.0926 (rank : 1025)	NC score	0.009880 (rank : 1447)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

BORG3_HUMAN
θ value	3.0926 (rank : 1026)	NC score	0.005814 (rank : 1488)
Query Neighborhood Hits	1243	Target Neighborhood Hits	36	Shared Neighborhood Hits	10
SwissProt Accessions	Q6NZY7, Q8TB51	Gene names	CDC42EP5, BORG3, CEP5
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 5 (Binder of Rho GTPases 3).

CABL2_HUMAN
θ value	3.0926 (rank : 1027)	NC score	0.011046 (rank : 1439)
Query Neighborhood Hits	1243	Target Neighborhood Hits	84	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CAC1H_HUMAN
θ value	3.0926 (rank : 1028)	NC score	0.007897 (rank : 1466)
Query Neighborhood Hits	1243	Target Neighborhood Hits	307	Shared Neighborhood Hits	86
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CBP_HUMAN
θ value	3.0926 (rank : 1029)	NC score	0.031028 (rank : 1278)
Query Neighborhood Hits	1243	Target Neighborhood Hits	941	Shared Neighborhood Hits	245
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CITE4_MOUSE
θ value	3.0926 (rank : 1030)	NC score	0.013767 (rank : 1418)
Query Neighborhood Hits	1243	Target Neighborhood Hits	73	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WUL8, Q66JX0, Q8R176, Q9CZV4	Gene names	Cited4, Mrg2
Domain Architecture	No domain graphic available
Description	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG- 2).

CLK2_HUMAN
θ value	3.0926 (rank : 1031)	NC score	0.525101 (rank : 799)
Query Neighborhood Hits	1243	Target Neighborhood Hits	752	Shared Neighborhood Hits	670
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK2_MOUSE
θ value	3.0926 (rank : 1032)	NC score	0.507863 (rank : 807)
Query Neighborhood Hits	1243	Target Neighborhood Hits	743	Shared Neighborhood Hits	664
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CO4A1_HUMAN
θ value	3.0926 (rank : 1033)	NC score	0.037586 (rank : 1232)
Query Neighborhood Hits	1243	Target Neighborhood Hits	425	Shared Neighborhood Hits	127
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO5A2_HUMAN
θ value	3.0926 (rank : 1034)	NC score	0.048060 (rank : 1184)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	203
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

COFA1_MOUSE
θ value	3.0926 (rank : 1035)	NC score	0.030892 (rank : 1280)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	95
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

COIA1_HUMAN
θ value	3.0926 (rank : 1036)	NC score	0.034290 (rank : 1252)
Query Neighborhood Hits	1243	Target Neighborhood Hits	447	Shared Neighborhood Hits	146
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

DIAP2_MOUSE
θ value	3.0926 (rank : 1037)	NC score	0.018305 (rank : 1380)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	68
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

FA47A_HUMAN
θ value	3.0926 (rank : 1038)	NC score	0.034026 (rank : 1255)
Query Neighborhood Hits	1243	Target Neighborhood Hits	451	Shared Neighborhood Hits	147
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FIGN_MOUSE
θ value	3.0926 (rank : 1039)	NC score	0.000966 (rank : 1549)
Query Neighborhood Hits	1243	Target Neighborhood Hits	165	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

HCN3_MOUSE
θ value	3.0926 (rank : 1040)	NC score	0.004896 (rank : 1501)
Query Neighborhood Hits	1243	Target Neighborhood Hits	112	Shared Neighborhood Hits	35
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

IF39_MOUSE
θ value	3.0926 (rank : 1041)	NC score	0.008872 (rank : 1458)
Query Neighborhood Hits	1243	Target Neighborhood Hits	206	Shared Neighborhood Hits	40
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

LRP10_HUMAN
θ value	3.0926 (rank : 1042)	NC score	0.000556 (rank : 1554)
Query Neighborhood Hits	1243	Target Neighborhood Hits	197	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

LZTS2_HUMAN
θ value	3.0926 (rank : 1043)	NC score	0.007348 (rank : 1470)
Query Neighborhood Hits	1243	Target Neighborhood Hits	427	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

MLL2_HUMAN
θ value	3.0926 (rank : 1044)	NC score	0.037503 (rank : 1233)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1788	Shared Neighborhood Hits	325
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL4_HUMAN
θ value	3.0926 (rank : 1045)	NC score	0.020242 (rank : 1362)
Query Neighborhood Hits	1243	Target Neighborhood Hits	722	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MNAB_HUMAN
θ value	3.0926 (rank : 1046)	NC score	0.003813 (rank : 1513)
Query Neighborhood Hits	1243	Target Neighborhood Hits	196	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

NUP53_MOUSE
θ value	3.0926 (rank : 1047)	NC score	0.013884 (rank : 1416)
Query Neighborhood Hits	1243	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

PCX3_MOUSE
θ value	3.0926 (rank : 1048)	NC score	0.014805 (rank : 1410)
Query Neighborhood Hits	1243	Target Neighborhood Hits	134	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

PO5FL_HUMAN
θ value	3.0926 (rank : 1049)	NC score	-0.003317 (rank : 1582)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	11
SwissProt Accessions	Q06416, Q9BZV9	Gene names	POU5F1P1, OTF3C, POU5FLC8
Domain Architecture
Description	POU domain, class 5, transcription factor 1-like protein 1 (Octamer- binding protein 3-like).

PO5FM_HUMAN
θ value	3.0926 (rank : 1050)	NC score	-0.003347 (rank : 1583)
Query Neighborhood Hits	1243	Target Neighborhood Hits	212	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZV7	Gene names	POU5F1P1, POU5FLC20
Domain Architecture
Description	POU domain, class 5, transcription factor 1-like protein 2.

PSD4_HUMAN
θ value	3.0926 (rank : 1051)	NC score	0.006778 (rank : 1477)
Query Neighborhood Hits	1243	Target Neighborhood Hits	178	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PXK_MOUSE
θ value	3.0926 (rank : 1052)	NC score	0.153252 (rank : 866)
Query Neighborhood Hits	1243	Target Neighborhood Hits	320	Shared Neighborhood Hits	201
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RIMB1_HUMAN
θ value	3.0926 (rank : 1053)	NC score	0.040495 (rank : 1215)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1479	Shared Neighborhood Hits	238
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SIX5_HUMAN
θ value	3.0926 (rank : 1054)	NC score	0.001217 (rank : 1546)
Query Neighborhood Hits	1243	Target Neighborhood Hits	386	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N196	Gene names	SIX5, DMAHP
Domain Architecture	No domain graphic available
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein).

SOX11_MOUSE
θ value	3.0926 (rank : 1055)	NC score	-0.001634 (rank : 1575)
Query Neighborhood Hits	1243	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q7M6Y2, O35178, O89036, Q04889, Q80XF0	Gene names	Sox11, Sox-11
Domain Architecture	No domain graphic available
Description	Transcription factor SOX-11.

SYN2_HUMAN
θ value	3.0926 (rank : 1056)	NC score	0.021781 (rank : 1351)
Query Neighborhood Hits	1243	Target Neighborhood Hits	213	Shared Neighborhood Hits	76
SwissProt Accessions	Q92777	Gene names	SYN2
Domain Architecture
Description	Synapsin-2 (Synapsin II).

WASF1_MOUSE
θ value	3.0926 (rank : 1057)	NC score	0.029205 (rank : 1291)
Query Neighborhood Hits	1243	Target Neighborhood Hits	261	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

ANR25_MOUSE
θ value	4.03905 (rank : 1058)	NC score	0.010146 (rank : 1444)
Query Neighborhood Hits	1243	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANX11_MOUSE
θ value	4.03905 (rank : 1059)	NC score	0.001999 (rank : 1533)
Query Neighborhood Hits	1243	Target Neighborhood Hits	200	Shared Neighborhood Hits	61
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

BAT3_MOUSE
θ value	4.03905 (rank : 1060)	NC score	0.033786 (rank : 1259)
Query Neighborhood Hits	1243	Target Neighborhood Hits	518	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

CIC_MOUSE
θ value	4.03905 (rank : 1061)	NC score	0.026496 (rank : 1308)
Query Neighborhood Hits	1243	Target Neighborhood Hits	742	Shared Neighborhood Hits	198
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

COBA2_MOUSE
θ value	4.03905 (rank : 1062)	NC score	0.037825 (rank : 1230)
Query Neighborhood Hits	1243	Target Neighborhood Hits	501	Shared Neighborhood Hits	142
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CP007_MOUSE
θ value	4.03905 (rank : 1063)	NC score	0.015072 (rank : 1405)
Query Neighborhood Hits	1243	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

CREB1_MOUSE
θ value	4.03905 (rank : 1064)	NC score	0.001147 (rank : 1548)
Query Neighborhood Hits	1243	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q01147	Gene names	Creb1, Creb-1
Domain Architecture
Description	cAMP response element-binding protein (CREB).

CRTC1_HUMAN
θ value	4.03905 (rank : 1065)	NC score	0.030089 (rank : 1287)
Query Neighborhood Hits	1243	Target Neighborhood Hits	319	Shared Neighborhood Hits	112
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

DAB2_MOUSE
θ value	4.03905 (rank : 1066)	NC score	0.009848 (rank : 1449)
Query Neighborhood Hits	1243	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

DREB_MOUSE
θ value	4.03905 (rank : 1067)	NC score	0.016852 (rank : 1391)
Query Neighborhood Hits	1243	Target Neighborhood Hits	446	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

F5006_MOUSE
θ value	4.03905 (rank : 1068)	NC score	0.652086 (rank : 713)
Query Neighborhood Hits	1243	Target Neighborhood Hits	793	Shared Neighborhood Hits	727
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

GP153_HUMAN
θ value	4.03905 (rank : 1069)	NC score	-0.003790 (rank : 1586)
Query Neighborhood Hits	1243	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

IQEC3_MOUSE
θ value	4.03905 (rank : 1070)	NC score	0.007475 (rank : 1469)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	79
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

JPH4_HUMAN
θ value	4.03905 (rank : 1071)	NC score	0.000242 (rank : 1558)
Query Neighborhood Hits	1243	Target Neighborhood Hits	103	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

KCNC3_HUMAN
θ value	4.03905 (rank : 1072)	NC score	-0.002662 (rank : 1579)
Query Neighborhood Hits	1243	Target Neighborhood Hits	256	Shared Neighborhood Hits	54
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

M3K14_MOUSE
θ value	4.03905 (rank : 1073)	NC score	0.682284 (rank : 650)
Query Neighborhood Hits	1243	Target Neighborhood Hits	889	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MAGC1_HUMAN
θ value	4.03905 (rank : 1074)	NC score	0.006991 (rank : 1473)
Query Neighborhood Hits	1243	Target Neighborhood Hits	431	Shared Neighborhood Hits	98
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MEF2B_HUMAN
θ value	4.03905 (rank : 1075)	NC score	0.011546 (rank : 1432)
Query Neighborhood Hits	1243	Target Neighborhood Hits	150	Shared Neighborhood Hits	65
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

MYST3_MOUSE
θ value	4.03905 (rank : 1076)	NC score	0.001521 (rank : 1542)
Query Neighborhood Hits	1243	Target Neighborhood Hits	688	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

NCOR1_MOUSE
θ value	4.03905 (rank : 1077)	NC score	0.011050 (rank : 1438)
Query Neighborhood Hits	1243	Target Neighborhood Hits	521	Shared Neighborhood Hits	77
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NOS1_HUMAN
θ value	4.03905 (rank : 1078)	NC score	0.001244 (rank : 1545)
Query Neighborhood Hits	1243	Target Neighborhood Hits	218	Shared Neighborhood Hits	42
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PP1RA_MOUSE
θ value	4.03905 (rank : 1079)	NC score	0.014833 (rank : 1408)
Query Neighborhood Hits	1243	Target Neighborhood Hits	175	Shared Neighborhood Hits	50
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

PRRT3_HUMAN
θ value	4.03905 (rank : 1080)	NC score	0.070302 (rank : 1046)
Query Neighborhood Hits	1243	Target Neighborhood Hits	998	Shared Neighborhood Hits	323
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RREB1_HUMAN
θ value	4.03905 (rank : 1081)	NC score	-0.017850 (rank : 1612)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	70
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

SELPL_MOUSE
θ value	4.03905 (rank : 1082)	NC score	0.030259 (rank : 1286)
Query Neighborhood Hits	1243	Target Neighborhood Hits	588	Shared Neighborhood Hits	151
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SNX19_HUMAN
θ value	4.03905 (rank : 1083)	NC score	0.008631 (rank : 1461)
Query Neighborhood Hits	1243	Target Neighborhood Hits	123	Shared Neighborhood Hits	28
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

SYNJ1_MOUSE
θ value	4.03905 (rank : 1084)	NC score	0.023822 (rank : 1335)
Query Neighborhood Hits	1243	Target Neighborhood Hits	516	Shared Neighborhood Hits	159
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TBX1_MOUSE
θ value	4.03905 (rank : 1085)	NC score	0.001795 (rank : 1536)
Query Neighborhood Hits	1243	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	P70323, Q60706, Q99MP0, Q99P22	Gene names	Tbx1
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T- box protein).

TBX4_MOUSE
θ value	4.03905 (rank : 1086)	NC score	0.002182 (rank : 1529)
Query Neighborhood Hits	1243	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	P70325, Q8R5F6	Gene names	Tbx4
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX4 (T-box protein 4).

TIF1B_HUMAN
θ value	4.03905 (rank : 1087)	NC score	0.004989 (rank : 1498)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	43
SwissProt Accessions	Q13263, O00677, Q7Z632, Q93040, Q96IM1	Gene names	TRIM28, KAP1, RNF96, TIF1B
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (RING finger protein 96).

UBP31_HUMAN
θ value	4.03905 (rank : 1088)	NC score	0.001882 (rank : 1535)
Query Neighborhood Hits	1243	Target Neighborhood Hits	293	Shared Neighborhood Hits	40
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

VASP_HUMAN
θ value	4.03905 (rank : 1089)	NC score	0.018607 (rank : 1376)
Query Neighborhood Hits	1243	Target Neighborhood Hits	201	Shared Neighborhood Hits	69
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

ZN318_MOUSE
θ value	4.03905 (rank : 1090)	NC score	0.011605 (rank : 1431)
Query Neighborhood Hits	1243	Target Neighborhood Hits	642	Shared Neighborhood Hits	80
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

BAI1_HUMAN
θ value	5.27518 (rank : 1091)	NC score	-0.003459 (rank : 1584)
Query Neighborhood Hits	1243	Target Neighborhood Hits	375	Shared Neighborhood Hits	59
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
θ value	5.27518 (rank : 1092)	NC score	-0.005701 (rank : 1593)
Query Neighborhood Hits	1243	Target Neighborhood Hits	340	Shared Neighborhood Hits	49
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CEL_HUMAN
θ value	5.27518 (rank : 1093)	NC score	0.047775 (rank : 1185)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	299
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CLIC6_MOUSE
θ value	5.27518 (rank : 1094)	NC score	0.004938 (rank : 1500)
Query Neighborhood Hits	1243	Target Neighborhood Hits	134	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

CNOT4_HUMAN
θ value	5.27518 (rank : 1095)	NC score	0.009760 (rank : 1450)
Query Neighborhood Hits	1243	Target Neighborhood Hits	207	Shared Neighborhood Hits	45
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CO4A2_MOUSE
θ value	5.27518 (rank : 1096)	NC score	0.039758 (rank : 1216)
Query Neighborhood Hits	1243	Target Neighborhood Hits	492	Shared Neighborhood Hits	153
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CO5A1_HUMAN
θ value	5.27518 (rank : 1097)	NC score	0.031621 (rank : 1272)
Query Neighborhood Hits	1243	Target Neighborhood Hits	434	Shared Neighborhood Hits	125
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO5A1_MOUSE
θ value	5.27518 (rank : 1098)	NC score	0.032195 (rank : 1268)
Query Neighborhood Hits	1243	Target Neighborhood Hits	419	Shared Neighborhood Hits	124
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

DDX51_HUMAN
θ value	5.27518 (rank : 1099)	NC score	-0.000117 (rank : 1561)
Query Neighborhood Hits	1243	Target Neighborhood Hits	332	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DYRK3_HUMAN
θ value	5.27518 (rank : 1100)	NC score	0.601471 (rank : 760)
Query Neighborhood Hits	1243	Target Neighborhood Hits	798	Shared Neighborhood Hits	712
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

EMID2_MOUSE
θ value	5.27518 (rank : 1101)	NC score	0.019266 (rank : 1369)
Query Neighborhood Hits	1243	Target Neighborhood Hits	201	Shared Neighborhood Hits	66
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

EPN1_MOUSE
θ value	5.27518 (rank : 1102)	NC score	0.014817 (rank : 1409)
Query Neighborhood Hits	1243	Target Neighborhood Hits	240	Shared Neighborhood Hits	78
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

HDA10_HUMAN
θ value	5.27518 (rank : 1103)	NC score	-0.000316 (rank : 1566)
Query Neighborhood Hits	1243	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q969S8, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2	Gene names	HDAC10
Domain Architecture
Description	Histone deacetylase 10 (HD10).

JAD1C_HUMAN
θ value	5.27518 (rank : 1104)	NC score	-0.001749 (rank : 1576)
Query Neighborhood Hits	1243	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	P41229	Gene names	SMCX, DXS1272E, JARID1C, XE169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (Protein SmcX) (Protein Xe169).

KS6C1_HUMAN
θ value	5.27518 (rank : 1105)	NC score	0.452701 (rank : 821)
Query Neighborhood Hits	1243	Target Neighborhood Hits	682	Shared Neighborhood Hits	592
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

MDC1_HUMAN
θ value	5.27518 (rank : 1106)	NC score	0.043309 (rank : 1201)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1446	Shared Neighborhood Hits	263
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MISS_MOUSE
θ value	5.27518 (rank : 1107)	NC score	0.052276 (rank : 1155)
Query Neighborhood Hits	1243	Target Neighborhood Hits	444	Shared Neighborhood Hits	194
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MOT8_HUMAN
θ value	5.27518 (rank : 1108)	NC score	0.001677 (rank : 1540)
Query Neighborhood Hits	1243	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P36021, Q7Z797	Gene names	SLC16A2, MCT8, XPCT
Domain Architecture	No domain graphic available
Description	Monocarboxylate transporter 8 (MCT 8) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter).

MUC2_HUMAN
θ value	5.27518 (rank : 1109)	NC score	0.016399 (rank : 1393)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	141
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

P73L_HUMAN
θ value	5.27518 (rank : 1110)	NC score	0.006894 (rank : 1475)
Query Neighborhood Hits	1243	Target Neighborhood Hits	102	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74	Gene names	TP73L, KET, P63, P73H, P73L
Domain Architecture	No domain graphic available
Description	Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).

PGCB_HUMAN
θ value	5.27518 (rank : 1111)	NC score	0.000165 (rank : 1560)
Query Neighborhood Hits	1243	Target Neighborhood Hits	478	Shared Neighborhood Hits	42
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

PHLPP_MOUSE
θ value	5.27518 (rank : 1112)	NC score	-0.006978 (rank : 1597)
Query Neighborhood Hits	1243	Target Neighborhood Hits	394	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PRG4_MOUSE
θ value	5.27518 (rank : 1113)	NC score	0.021456 (rank : 1355)
Query Neighborhood Hits	1243	Target Neighborhood Hits	624	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRR3_MOUSE
θ value	5.27518 (rank : 1114)	NC score	0.013529 (rank : 1420)
Query Neighborhood Hits	1243	Target Neighborhood Hits	39	Shared Neighborhood Hits	11
SwissProt Accessions	Q811B5, Q91YI5	Gene names	Prr3, Cat56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

PSMF1_MOUSE
θ value	5.27518 (rank : 1115)	NC score	0.010959 (rank : 1441)
Query Neighborhood Hits	1243	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHL8, Q8C0G9	Gene names	Psmf1
Domain Architecture	No domain graphic available
Description	Proteasome inhibitor PI31 subunit.

RGS3_HUMAN
θ value	5.27518 (rank : 1116)	NC score	0.061206 (rank : 1092)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1375	Shared Neighborhood Hits	362
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RIN3_HUMAN
θ value	5.27518 (rank : 1117)	NC score	0.017366 (rank : 1386)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RSMB_HUMAN
θ value	5.27518 (rank : 1118)	NC score	0.008729 (rank : 1459)
Query Neighborhood Hits	1243	Target Neighborhood Hits	117	Shared Neighborhood Hits	38
SwissProt Accessions	P14678, Q15490, Q9UIS5	Gene names	SNRPB, COD, SNRPB1
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/Sm-B') (SmB/SmB').

SASH1_HUMAN
θ value	5.27518 (rank : 1119)	NC score	0.049948 (rank : 1179)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	97
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SCAR3_HUMAN
θ value	5.27518 (rank : 1120)	NC score	0.021301 (rank : 1356)
Query Neighborhood Hits	1243	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q6AZY7, Q9UM15, Q9UM16	Gene names	SCARA3, CSR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3 (Cellular stress response gene protein).

SF3B2_HUMAN
θ value	5.27518 (rank : 1121)	NC score	0.016237 (rank : 1394)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	30
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SGIP1_HUMAN
θ value	5.27518 (rank : 1122)	NC score	0.019781 (rank : 1366)
Query Neighborhood Hits	1243	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SHAN1_HUMAN
θ value	5.27518 (rank : 1123)	NC score	0.046564 (rank : 1188)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1041	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	5.27518 (rank : 1124)	NC score	0.057391 (rank : 1115)
Query Neighborhood Hits	1243	Target Neighborhood Hits	446	Shared Neighborhood Hits	101
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SMRC2_MOUSE
θ value	5.27518 (rank : 1125)	NC score	0.021278 (rank : 1357)
Query Neighborhood Hits	1243	Target Neighborhood Hits	487	Shared Neighborhood Hits	95
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SP7_MOUSE
θ value	5.27518 (rank : 1126)	NC score	-0.020639 (rank : 1618)
Query Neighborhood Hits	1243	Target Neighborhood Hits	756	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VI67, Q8C5R3, Q8C6A7	Gene names	Sp7, Osx
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix) (C22).

SRRM1_MOUSE
θ value	5.27518 (rank : 1127)	NC score	0.056248 (rank : 1120)
Query Neighborhood Hits	1243	Target Neighborhood Hits	966	Shared Neighborhood Hits	234
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SYNJ1_HUMAN
θ value	5.27518 (rank : 1128)	NC score	0.018662 (rank : 1374)
Query Neighborhood Hits	1243	Target Neighborhood Hits	498	Shared Neighborhood Hits	145
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TAU_HUMAN
θ value	5.27518 (rank : 1129)	NC score	0.032239 (rank : 1267)
Query Neighborhood Hits	1243	Target Neighborhood Hits	448	Shared Neighborhood Hits	146
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TCF8_MOUSE
θ value	5.27518 (rank : 1130)	NC score	-0.021099 (rank : 1620)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1067	Shared Neighborhood Hits	77
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

TNR1B_MOUSE
θ value	5.27518 (rank : 1131)	NC score	-0.001024 (rank : 1569)
Query Neighborhood Hits	1243	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

TRI47_MOUSE
θ value	5.27518 (rank : 1132)	NC score	-0.003226 (rank : 1581)
Query Neighborhood Hits	1243	Target Neighborhood Hits	295	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

ZN694_HUMAN
θ value	5.27518 (rank : 1133)	NC score	-0.022464 (rank : 1625)
Query Neighborhood Hits	1243	Target Neighborhood Hits	764	Shared Neighborhood Hits	30
SwissProt Accessions	Q63HK3, Q6ZN77	Gene names	ZNF694
Domain Architecture	No domain graphic available
Description	Zinc finger protein 694.

APBA3_HUMAN
θ value	6.88961 (rank : 1134)	NC score	0.001512 (rank : 1543)
Query Neighborhood Hits	1243	Target Neighborhood Hits	201	Shared Neighborhood Hits	35
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ASPP2_HUMAN
θ value	6.88961 (rank : 1135)	NC score	0.051577 (rank : 1161)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1156	Shared Neighborhood Hits	166
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BACH1_MOUSE
θ value	6.88961 (rank : 1136)	NC score	-0.010177 (rank : 1608)
Query Neighborhood Hits	1243	Target Neighborhood Hits	289	Shared Neighborhood Hits	10
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

CABIN_HUMAN
θ value	6.88961 (rank : 1137)	NC score	0.030460 (rank : 1285)
Query Neighborhood Hits	1243	Target Neighborhood Hits	490	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CABL2_MOUSE
θ value	6.88961 (rank : 1138)	NC score	0.006866 (rank : 1476)
Query Neighborhood Hits	1243	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CG1_HUMAN
θ value	6.88961 (rank : 1139)	NC score	0.019717 (rank : 1367)
Query Neighborhood Hits	1243	Target Neighborhood Hits	222	Shared Neighborhood Hits	77
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CJ108_HUMAN
θ value	6.88961 (rank : 1140)	NC score	0.024684 (rank : 1324)
Query Neighborhood Hits	1243	Target Neighborhood Hits	165	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

CRSP7_HUMAN
θ value	6.88961 (rank : 1141)	NC score	0.029038 (rank : 1292)
Query Neighborhood Hits	1243	Target Neighborhood Hits	247	Shared Neighborhood Hits	92
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

CT128_HUMAN
θ value	6.88961 (rank : 1142)	NC score	0.005242 (rank : 1492)
Query Neighborhood Hits	1243	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQN1, Q5JWN6, Q8N276	Gene names	C20orf128
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf128.

DIAP2_HUMAN
θ value	6.88961 (rank : 1143)	NC score	0.015648 (rank : 1400)
Query Neighborhood Hits	1243	Target Neighborhood Hits	342	Shared Neighborhood Hits	67
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

DYRK2_HUMAN
θ value	6.88961 (rank : 1144)	NC score	0.580546 (rank : 773)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	708
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

EVL_HUMAN
θ value	6.88961 (rank : 1145)	NC score	0.020459 (rank : 1360)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

EWS_MOUSE
θ value	6.88961 (rank : 1146)	NC score	0.006403 (rank : 1480)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

HIPK3_HUMAN
θ value	6.88961 (rank : 1147)	NC score	0.608756 (rank : 752)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	726
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	6.88961 (rank : 1148)	NC score	0.609854 (rank : 750)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	731
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

IL32_HUMAN
θ value	6.88961 (rank : 1149)	NC score	0.005964 (rank : 1486)
Query Neighborhood Hits	1243	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P24001, Q96GK9	Gene names	IL32, NK4
Domain Architecture	No domain graphic available
Description	Interleukin-32 precursor (IL-32) (Natural killer cells protein 4).

INSM1_HUMAN
θ value	6.88961 (rank : 1150)	NC score	-0.017481 (rank : 1611)
Query Neighborhood Hits	1243	Target Neighborhood Hits	683	Shared Neighborhood Hits	34
SwissProt Accessions	Q01101	Gene names	INSM1, IA1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

ITCH_MOUSE
θ value	6.88961 (rank : 1151)	NC score	-0.004169 (rank : 1588)
Query Neighborhood Hits	1243	Target Neighborhood Hits	127	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

KLF13_MOUSE
θ value	6.88961 (rank : 1152)	NC score	-0.021429 (rank : 1621)
Query Neighborhood Hits	1243	Target Neighborhood Hits	757	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JJZ6, Q9ESX3, Q9JHF8	Gene names	Klf13, Bteb3, Fklf2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Erythroid transcription factor FKLF-2).

KLHL1_HUMAN
θ value	6.88961 (rank : 1153)	NC score	-0.009416 (rank : 1605)
Query Neighborhood Hits	1243	Target Neighborhood Hits	195	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR64, Q5VZ64, Q9H4X4, Q9NR65, Q9P238	Gene names	KLHL1, KIAA1490
Domain Architecture
Description	Kelch-like protein 1.

LPP_HUMAN
θ value	6.88961 (rank : 1154)	NC score	0.042415 (rank : 1204)
Query Neighborhood Hits	1243	Target Neighborhood Hits	775	Shared Neighborhood Hits	234
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

LRC47_HUMAN
θ value	6.88961 (rank : 1155)	NC score	-0.008609 (rank : 1604)
Query Neighborhood Hits	1243	Target Neighborhood Hits	300	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N1G4, Q9ULN5	Gene names	LRRC47, KIAA1185
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 47.

MAML1_HUMAN
θ value	6.88961 (rank : 1156)	NC score	0.010990 (rank : 1440)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MUCDL_MOUSE
θ value	6.88961 (rank : 1157)	NC score	0.006063 (rank : 1485)
Query Neighborhood Hits	1243	Target Neighborhood Hits	461	Shared Neighborhood Hits	100
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MY18B_HUMAN
θ value	6.88961 (rank : 1158)	NC score	0.014375 (rank : 1413)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1299	Shared Neighborhood Hits	179
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

NCOA2_HUMAN
θ value	6.88961 (rank : 1159)	NC score	0.004938 (rank : 1499)
Query Neighborhood Hits	1243	Target Neighborhood Hits	281	Shared Neighborhood Hits	69
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NJMU_HUMAN
θ value	6.88961 (rank : 1160)	NC score	0.003231 (rank : 1518)
Query Neighborhood Hits	1243	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAS0, Q7Z2H4	Gene names	C17orf75
Domain Architecture	No domain graphic available
Description	Protein Njmu-R1.

NOS3_MOUSE
θ value	6.88961 (rank : 1161)	NC score	0.003470 (rank : 1516)
Query Neighborhood Hits	1243	Target Neighborhood Hits	63	Shared Neighborhood Hits	23
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

OTP_MOUSE
θ value	6.88961 (rank : 1162)	NC score	-0.010116 (rank : 1606)
Query Neighborhood Hits	1243	Target Neighborhood Hits	387	Shared Neighborhood Hits	27
SwissProt Accessions	O09113	Gene names	Otp
Domain Architecture
Description	Homeobox protein orthopedia.

PELP1_MOUSE
θ value	6.88961 (rank : 1163)	NC score	0.043397 (rank : 1200)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	202
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PER2_HUMAN
θ value	6.88961 (rank : 1164)	NC score	0.001660 (rank : 1541)
Query Neighborhood Hits	1243	Target Neighborhood Hits	170	Shared Neighborhood Hits	37
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PMYT1_MOUSE
θ value	6.88961 (rank : 1165)	NC score	0.691459 (rank : 616)
Query Neighborhood Hits	1243	Target Neighborhood Hits	910	Shared Neighborhood Hits	781
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PO121_HUMAN
θ value	6.88961 (rank : 1166)	NC score	0.027463 (rank : 1302)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

POGZ_MOUSE
θ value	6.88961 (rank : 1167)	NC score	-0.018671 (rank : 1613)
Query Neighborhood Hits	1243	Target Neighborhood Hits	765	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZH4, Q4VA94, Q80TZ8, Q8C0K1, Q8K294	Gene names	Pogz, Kiaa0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

PPRB_HUMAN
θ value	6.88961 (rank : 1168)	NC score	0.021955 (rank : 1349)
Query Neighborhood Hits	1243	Target Neighborhood Hits	311	Shared Neighborhood Hits	63
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

RFIP3_HUMAN
θ value	6.88961 (rank : 1169)	NC score	0.008905 (rank : 1457)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1055	Shared Neighborhood Hits	119
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RKHD1_HUMAN
θ value	6.88961 (rank : 1170)	NC score	0.002873 (rank : 1521)
Query Neighborhood Hits	1243	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

SEM6B_HUMAN
θ value	6.88961 (rank : 1171)	NC score	-0.000906 (rank : 1568)
Query Neighborhood Hits	1243	Target Neighborhood Hits	187	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

SETBP_HUMAN
θ value	6.88961 (rank : 1172)	NC score	0.008988 (rank : 1454)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SMCA4_HUMAN
θ value	6.88961 (rank : 1173)	NC score	0.007964 (rank : 1465)
Query Neighborhood Hits	1243	Target Neighborhood Hits	597	Shared Neighborhood Hits	131
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SMR3A_HUMAN
θ value	6.88961 (rank : 1174)	NC score	0.024697 (rank : 1323)
Query Neighborhood Hits	1243	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

SRRM2_MOUSE
θ value	6.88961 (rank : 1175)	NC score	0.059500 (rank : 1101)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1470	Shared Neighborhood Hits	277
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SSBP4_HUMAN
θ value	6.88961 (rank : 1176)	NC score	0.051268 (rank : 1167)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	267
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SYN1_MOUSE
θ value	6.88961 (rank : 1177)	NC score	0.027064 (rank : 1306)
Query Neighborhood Hits	1243	Target Neighborhood Hits	363	Shared Neighborhood Hits	116
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

SYNG_MOUSE
θ value	6.88961 (rank : 1178)	NC score	0.008236 (rank : 1462)
Query Neighborhood Hits	1243	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

SYW_HUMAN
θ value	6.88961 (rank : 1179)	NC score	0.002338 (rank : 1527)
Query Neighborhood Hits	1243	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P23381, P78535, Q9UDL3	Gene names	WARS, WRS
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) (IFP53) (hWRS).

T2FA_HUMAN
θ value	6.88961 (rank : 1180)	NC score	0.005250 (rank : 1491)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	26
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

TCAL3_HUMAN
θ value	6.88961 (rank : 1181)	NC score	0.000430 (rank : 1556)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	31
SwissProt Accessions	Q969E4	Gene names	TCEAL3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

TNR8_MOUSE
θ value	6.88961 (rank : 1182)	NC score	0.007268 (rank : 1471)
Query Neighborhood Hits	1243	Target Neighborhood Hits	208	Shared Neighborhood Hits	35
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

TROAP_HUMAN
θ value	6.88961 (rank : 1183)	NC score	0.017051 (rank : 1388)
Query Neighborhood Hits	1243	Target Neighborhood Hits	258	Shared Neighborhood Hits	87
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

WASP_HUMAN
θ value	6.88961 (rank : 1184)	NC score	0.031932 (rank : 1271)
Query Neighborhood Hits	1243	Target Neighborhood Hits	195	Shared Neighborhood Hits	82
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

ZO1_MOUSE
θ value	6.88961 (rank : 1185)	NC score	-0.001374 (rank : 1573)
Query Neighborhood Hits	1243	Target Neighborhood Hits	453	Shared Neighborhood Hits	67
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

A4_HUMAN
θ value	8.99809 (rank : 1186)	NC score	0.004707 (rank : 1505)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	31
SwissProt Accessions	P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q9BT38, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58	Gene names	APP, A4, AD1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma- secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

AB1IP_HUMAN
θ value	8.99809 (rank : 1187)	NC score	0.024280 (rank : 1330)
Query Neighborhood Hits	1243	Target Neighborhood Hits	213	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

ADDA_HUMAN
θ value	8.99809 (rank : 1188)	NC score	0.002445 (rank : 1526)
Query Neighborhood Hits	1243	Target Neighborhood Hits	108	Shared Neighborhood Hits	22
SwissProt Accessions	P35611, Q13734, Q14729, Q16156, Q9UJB6	Gene names	ADD1, ADDA
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

ARI1A_HUMAN
θ value	8.99809 (rank : 1189)	NC score	0.033458 (rank : 1261)
Query Neighborhood Hits	1243	Target Neighborhood Hits	787	Shared Neighborhood Hits	229
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ARS2_HUMAN
θ value	8.99809 (rank : 1190)	NC score	0.000811 (rank : 1552)
Query Neighborhood Hits	1243	Target Neighborhood Hits	186	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

ARS2_MOUSE
θ value	8.99809 (rank : 1191)	NC score	0.000907 (rank : 1551)
Query Neighborhood Hits	1243	Target Neighborhood Hits	212	Shared Neighborhood Hits	25
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

AUXI_HUMAN
θ value	8.99809 (rank : 1192)	NC score	0.013732 (rank : 1419)
Query Neighborhood Hits	1243	Target Neighborhood Hits	99	Shared Neighborhood Hits	10
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

BLNK_MOUSE
θ value	8.99809 (rank : 1193)	NC score	0.070978 (rank : 1042)
Query Neighborhood Hits	1243	Target Neighborhood Hits	296	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BRD2_HUMAN
θ value	8.99809 (rank : 1194)	NC score	0.002712 (rank : 1522)
Query Neighborhood Hits	1243	Target Neighborhood Hits	242	Shared Neighborhood Hits	31
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

BRD4_HUMAN
θ value	8.99809 (rank : 1195)	NC score	0.016208 (rank : 1395)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	152
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CDT1_MOUSE
θ value	8.99809 (rank : 1196)	NC score	0.006551 (rank : 1478)
Query Neighborhood Hits	1243	Target Neighborhood Hits	72	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CN032_HUMAN
θ value	8.99809 (rank : 1197)	NC score	0.027612 (rank : 1298)
Query Neighborhood Hits	1243	Target Neighborhood Hits	267	Shared Neighborhood Hits	90
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CO1A2_MOUSE
θ value	8.99809 (rank : 1198)	NC score	0.034679 (rank : 1247)
Query Neighborhood Hits	1243	Target Neighborhood Hits	388	Shared Neighborhood Hits	110
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CUTL2_MOUSE
θ value	8.99809 (rank : 1199)	NC score	0.001787 (rank : 1537)
Query Neighborhood Hits	1243	Target Neighborhood Hits	771	Shared Neighborhood Hits	83
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

DOK2_HUMAN
θ value	8.99809 (rank : 1200)	NC score	-0.000248 (rank : 1564)
Query Neighborhood Hits	1243	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

DUS8_HUMAN
θ value	8.99809 (rank : 1201)	NC score	0.004290 (rank : 1510)
Query Neighborhood Hits	1243	Target Neighborhood Hits	161	Shared Neighborhood Hits	42
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

DYR1B_MOUSE
θ value	8.99809 (rank : 1202)	NC score	0.575570 (rank : 779)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	702
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

EVX2_HUMAN
θ value	8.99809 (rank : 1203)	NC score	-0.010177 (rank : 1607)
Query Neighborhood Hits	1243	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	Q03828	Gene names	EVX2
Domain Architecture
Description	Homeobox even-skipped homolog protein 2 (EVX-2).

EWS_HUMAN
θ value	8.99809 (rank : 1204)	NC score	0.007737 (rank : 1467)
Query Neighborhood Hits	1243	Target Neighborhood Hits	249	Shared Neighborhood Hits	50
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

FMNL_MOUSE
θ value	8.99809 (rank : 1205)	NC score	0.023051 (rank : 1343)
Query Neighborhood Hits	1243	Target Neighborhood Hits	428	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

FYB_MOUSE
θ value	8.99809 (rank : 1206)	NC score	0.007718 (rank : 1468)
Query Neighborhood Hits	1243	Target Neighborhood Hits	194	Shared Neighborhood Hits	39
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GSCR1_HUMAN
θ value	8.99809 (rank : 1207)	NC score	0.036571 (rank : 1238)
Query Neighborhood Hits	1243	Target Neighborhood Hits	674	Shared Neighborhood Hits	171
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

GTSE1_MOUSE
θ value	8.99809 (rank : 1208)	NC score	0.014195 (rank : 1414)
Query Neighborhood Hits	1243	Target Neighborhood Hits	245	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

HCN4_HUMAN
θ value	8.99809 (rank : 1209)	NC score	0.011104 (rank : 1437)
Query Neighborhood Hits	1243	Target Neighborhood Hits	303	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

IRAK3_HUMAN
θ value	8.99809 (rank : 1210)	NC score	0.721262 (rank : 480)
Query Neighborhood Hits	1243	Target Neighborhood Hits	644	Shared Neighborhood Hits	597
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRS2_HUMAN
θ value	8.99809 (rank : 1211)	NC score	0.024193 (rank : 1332)
Query Neighborhood Hits	1243	Target Neighborhood Hits	262	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

K0406_MOUSE
θ value	8.99809 (rank : 1212)	NC score	0.002172 (rank : 1530)
Query Neighborhood Hits	1243	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

KBTBB_HUMAN
θ value	8.99809 (rank : 1213)	NC score	-0.003493 (rank : 1585)
Query Neighborhood Hits	1243	Target Neighborhood Hits	195	Shared Neighborhood Hits	22
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

KC1AL_HUMAN
θ value	8.99809 (rank : 1214)	NC score	0.516267 (rank : 802)
Query Neighborhood Hits	1243	Target Neighborhood Hits	734	Shared Neighborhood Hits	661
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KLD7B_HUMAN
θ value	8.99809 (rank : 1215)	NC score	-0.003907 (rank : 1587)
Query Neighborhood Hits	1243	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q96G42	Gene names	KLHDC7B
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 7B.

KLF2_MOUSE
θ value	8.99809 (rank : 1216)	NC score	-0.021802 (rank : 1622)
Query Neighborhood Hits	1243	Target Neighborhood Hits	738	Shared Neighborhood Hits	39
SwissProt Accessions	Q60843	Gene names	Klf2, Lklf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 2 (Lung krueppel-like factor).

LARP4_MOUSE
θ value	8.99809 (rank : 1217)	NC score	0.011847 (rank : 1428)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

LAX1_MOUSE
θ value	8.99809 (rank : 1218)	NC score	0.002584 (rank : 1525)
Query Neighborhood Hits	1243	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHB3, Q8BS18, Q8CGV1	Gene names	Lax1, Lax
Domain Architecture	No domain graphic available
Description	Lymphocyte transmembrane adapter 1 (Membrane-associated adapter protein LAX) (Linker for activation of X cells).

M3K14_HUMAN
θ value	8.99809 (rank : 1219)	NC score	0.698934 (rank : 582)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	755
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

MTF1_HUMAN
θ value	8.99809 (rank : 1220)	NC score	-0.020601 (rank : 1617)
Query Neighborhood Hits	1243	Target Neighborhood Hits	814	Shared Neighborhood Hits	51
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

MUC13_MOUSE
θ value	8.99809 (rank : 1221)	NC score	0.021837 (rank : 1350)
Query Neighborhood Hits	1243	Target Neighborhood Hits	447	Shared Neighborhood Hits	75
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

NASP_HUMAN
θ value	8.99809 (rank : 1222)	NC score	0.002292 (rank : 1528)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	68
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

NIBL_HUMAN
θ value	8.99809 (rank : 1223)	NC score	0.005171 (rank : 1495)
Query Neighborhood Hits	1243	Target Neighborhood Hits	61	Shared Neighborhood Hits	18
SwissProt Accessions	Q96TA1, Q9BUS2, Q9NT35	Gene names	C9orf88
Domain Architecture	No domain graphic available
Description	Niban-like protein (Meg-3).

NOS1_MOUSE
θ value	8.99809 (rank : 1224)	NC score	-0.001367 (rank : 1572)
Query Neighborhood Hits	1243	Target Neighborhood Hits	155	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NR1H2_HUMAN
θ value	8.99809 (rank : 1225)	NC score	-0.007644 (rank : 1602)
Query Neighborhood Hits	1243	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

OSBP2_HUMAN
θ value	8.99809 (rank : 1226)	NC score	-0.000178 (rank : 1562)
Query Neighborhood Hits	1243	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PKP4_HUMAN
θ value	8.99809 (rank : 1227)	NC score	0.000537 (rank : 1555)
Query Neighborhood Hits	1243	Target Neighborhood Hits	107	Shared Neighborhood Hits	22
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

PRR6_HUMAN
θ value	8.99809 (rank : 1228)	NC score	0.008018 (rank : 1464)
Query Neighborhood Hits	1243	Target Neighborhood Hits	39	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z7K6, Q3L8N5, Q8NFH6	Gene names	PRR6
Domain Architecture	No domain graphic available
Description	Proline-rich protein 6 (Nuclear protein p30).

RBM22_HUMAN
θ value	8.99809 (rank : 1229)	NC score	0.002000 (rank : 1531)
Query Neighborhood Hits	1243	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NW64, O95607	Gene names	RBM22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RBM22_MOUSE
θ value	8.99809 (rank : 1230)	NC score	0.002000 (rank : 1532)
Query Neighborhood Hits	1243	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BHS3, Q3TJB0, Q9CXA0	Gene names	Rbm22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RFX1_HUMAN
θ value	8.99809 (rank : 1231)	NC score	0.012593 (rank : 1424)
Query Neighborhood Hits	1243	Target Neighborhood Hits	256	Shared Neighborhood Hits	78
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SF01_HUMAN
θ value	8.99809 (rank : 1232)	NC score	0.018642 (rank : 1375)
Query Neighborhood Hits	1243	Target Neighborhood Hits	287	Shared Neighborhood Hits	84
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SF01_MOUSE
θ value	8.99809 (rank : 1233)	NC score	0.016853 (rank : 1389)
Query Neighborhood Hits	1243	Target Neighborhood Hits	240	Shared Neighborhood Hits	69
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SGIP1_MOUSE
θ value	8.99809 (rank : 1234)	NC score	0.017818 (rank : 1383)
Query Neighborhood Hits	1243	Target Neighborhood Hits	180	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SIT1_HUMAN
θ value	8.99809 (rank : 1235)	NC score	0.003614 (rank : 1515)
Query Neighborhood Hits	1243	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3P8	Gene names	SIT1, SIT
Domain Architecture	No domain graphic available
Description	Signaling threshold-regulating transmembrane adapter 1 precursor (Suppression-inducing transmembrane adapter 1) (SHP2-interacting transmembrane adapter protein) (gp30/40).

SMRC2_HUMAN
θ value	8.99809 (rank : 1236)	NC score	0.023191 (rank : 1342)
Query Neighborhood Hits	1243	Target Neighborhood Hits	499	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SON_MOUSE
θ value	8.99809 (rank : 1237)	NC score	0.043765 (rank : 1197)
Query Neighborhood Hits	1243	Target Neighborhood Hits	957	Shared Neighborhood Hits	250
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SORC3_MOUSE
θ value	8.99809 (rank : 1238)	NC score	-0.000649 (rank : 1567)
Query Neighborhood Hits	1243	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SPR2D_MOUSE
θ value	8.99809 (rank : 1239)	NC score	0.008915 (rank : 1455)
Query Neighborhood Hits	1243	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

STRC_MOUSE
θ value	8.99809 (rank : 1240)	NC score	0.003667 (rank : 1514)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VIM6	Gene names	Strc
Domain Architecture	No domain graphic available
Description	Stereocilin precursor.

TBX21_MOUSE
θ value	8.99809 (rank : 1241)	NC score	0.003143 (rank : 1519)
Query Neighborhood Hits	1243	Target Neighborhood Hits	116	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

TCRG1_MOUSE
θ value	8.99809 (rank : 1242)	NC score	0.016448 (rank : 1392)
Query Neighborhood Hits	1243	Target Neighborhood Hits	947	Shared Neighborhood Hits	123
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TENS1_HUMAN
θ value	8.99809 (rank : 1243)	NC score	0.044355 (rank : 1195)
Query Neighborhood Hits	1243	Target Neighborhood Hits	400	Shared Neighborhood Hits	112
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

AAK1_HUMAN
θ value	θ > 10 (rank : 1244)	NC score	0.658137 (rank : 706)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1077	Shared Neighborhood Hits	797
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ABI2_HUMAN
θ value	θ > 10 (rank : 1245)	NC score	0.051474 (rank : 1163)
Query Neighborhood Hits	1243	Target Neighborhood Hits	350	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

AHI1_HUMAN
θ value	θ > 10 (rank : 1246)	NC score	0.063814 (rank : 1075)
Query Neighborhood Hits	1243	Target Neighborhood Hits	537	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 1247)	NC score	0.061917 (rank : 1085)
Query Neighborhood Hits	1243	Target Neighborhood Hits	496	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AL2S2_HUMAN
θ value	θ > 10 (rank : 1248)	NC score	0.700111 (rank : 576)
Query Neighborhood Hits	1243	Target Neighborhood Hits	727	Shared Neighborhood Hits	673
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 1249)	NC score	0.692161 (rank : 609)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	655
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

ANM2_HUMAN
θ value	θ > 10 (rank : 1250)	NC score	0.069110 (rank : 1052)
Query Neighborhood Hits	1243	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 1251)	NC score	0.064467 (rank : 1069)
Query Neighborhood Hits	1243	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_HUMAN
θ value	θ > 10 (rank : 1252)	NC score	0.111916 (rank : 923)
Query Neighborhood Hits	1243	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 1253)	NC score	0.083536 (rank : 1006)
Query Neighborhood Hits	1243	Target Neighborhood Hits	134	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG7_MOUSE
θ value	θ > 10 (rank : 1254)	NC score	0.050293 (rank : 1177)
Query Neighborhood Hits	1243	Target Neighborhood Hits	396	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ASPP1_HUMAN
θ value	θ > 10 (rank : 1255)	NC score	0.052094 (rank : 1158)
Query Neighborhood Hits	1243	Target Neighborhood Hits	956	Shared Neighborhood Hits	126
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ATL3_HUMAN
θ value	θ > 10 (rank : 1256)	NC score	0.050565 (rank : 1172)
Query Neighborhood Hits	1243	Target Neighborhood Hits	414	Shared Neighborhood Hits	47
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

BCAR3_HUMAN
θ value	θ > 10 (rank : 1257)	NC score	0.050472 (rank : 1174)
Query Neighborhood Hits	1243	Target Neighborhood Hits	129	Shared Neighborhood Hits	27
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 1258)	NC score	0.050999 (rank : 1170)
Query Neighborhood Hits	1243	Target Neighborhood Hits	127	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCL9_HUMAN
θ value	θ > 10 (rank : 1259)	NC score	0.050016 (rank : 1178)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1008	Shared Neighborhood Hits	296
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BLNK_HUMAN
θ value	θ > 10 (rank : 1260)	NC score	0.062143 (rank : 1084)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BOC_HUMAN
θ value	θ > 10 (rank : 1261)	NC score	0.106354 (rank : 938)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BOC_MOUSE
θ value	θ > 10 (rank : 1262)	NC score	0.099609 (rank : 961)
Query Neighborhood Hits	1243	Target Neighborhood Hits	433	Shared Neighborhood Hits	82
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1263)	NC score	0.052458 (rank : 1153)
Query Neighborhood Hits	1243	Target Neighborhood Hits	208	Shared Neighborhood Hits	104
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1_HUMAN
θ value	θ > 10 (rank : 1264)	NC score	0.247817 (rank : 844)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	370
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

BUB1_MOUSE
θ value	θ > 10 (rank : 1265)	NC score	0.351318 (rank : 830)
Query Neighborhood Hits	1243	Target Neighborhood Hits	583	Shared Neighborhood Hits	473
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CAMKV_HUMAN
θ value	θ > 10 (rank : 1266)	NC score	0.628632 (rank : 735)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1084	Shared Neighborhood Hits	776
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	θ > 10 (rank : 1267)	NC score	0.629726 (rank : 731)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	719
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CD22_HUMAN
θ value	θ > 10 (rank : 1268)	NC score	0.060301 (rank : 1095)
Query Neighborhood Hits	1243	Target Neighborhood Hits	365	Shared Neighborhood Hits	41
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD2AP_HUMAN
θ value	θ > 10 (rank : 1269)	NC score	0.052634 (rank : 1151)
Query Neighborhood Hits	1243	Target Neighborhood Hits	315	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CDC7_HUMAN
θ value	θ > 10 (rank : 1270)	NC score	0.452121 (rank : 822)
Query Neighborhood Hits	1243	Target Neighborhood Hits	652	Shared Neighborhood Hits	571
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDC7_MOUSE
θ value	θ > 10 (rank : 1271)	NC score	0.434048 (rank : 825)
Query Neighborhood Hits	1243	Target Neighborhood Hits	641	Shared Neighborhood Hits	567
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDON_HUMAN
θ value	θ > 10 (rank : 1272)	NC score	0.103393 (rank : 951)
Query Neighborhood Hits	1243	Target Neighborhood Hits	412	Shared Neighborhood Hits	68
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_MOUSE
θ value	θ > 10 (rank : 1273)	NC score	0.099935 (rank : 959)
Query Neighborhood Hits	1243	Target Neighborhood Hits	410	Shared Neighborhood Hits	67
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CEAM1_MOUSE
θ value	θ > 10 (rank : 1274)	NC score	0.058950 (rank : 1105)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	43
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

CEAM5_HUMAN
θ value	θ > 10 (rank : 1275)	NC score	0.051601 (rank : 1160)
Query Neighborhood Hits	1243	Target Neighborhood Hits	343	Shared Neighborhood Hits	44
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

CHIN_HUMAN
θ value	θ > 10 (rank : 1276)	NC score	0.077781 (rank : 1023)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1277)	NC score	0.079274 (rank : 1017)
Query Neighborhood Hits	1243	Target Neighborhood Hits	229	Shared Neighborhood Hits	66
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1278)	NC score	0.078397 (rank : 1020)
Query Neighborhood Hits	1243	Target Neighborhood Hits	220	Shared Neighborhood Hits	64
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHL1_HUMAN
θ value	θ > 10 (rank : 1279)	NC score	0.092864 (rank : 982)
Query Neighborhood Hits	1243	Target Neighborhood Hits	413	Shared Neighborhood Hits	80
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CHL1_MOUSE
θ value	θ > 10 (rank : 1280)	NC score	0.090089 (rank : 988)
Query Neighborhood Hits	1243	Target Neighborhood Hits	402	Shared Neighborhood Hits	76
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CI094_HUMAN
θ value	θ > 10 (rank : 1281)	NC score	0.059434 (rank : 1102)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CIP4_HUMAN
θ value	θ > 10 (rank : 1282)	NC score	0.086074 (rank : 1001)
Query Neighborhood Hits	1243	Target Neighborhood Hits	374	Shared Neighborhood Hits	49
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CLK3_HUMAN
θ value	θ > 10 (rank : 1283)	NC score	0.517012 (rank : 800)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	663
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	θ > 10 (rank : 1284)	NC score	0.516702 (rank : 801)
Query Neighborhood Hits	1243	Target Neighborhood Hits	761	Shared Neighborhood Hits	663
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CNTN1_HUMAN
θ value	θ > 10 (rank : 1285)	NC score	0.090572 (rank : 986)
Query Neighborhood Hits	1243	Target Neighborhood Hits	431	Shared Neighborhood Hits	77
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
θ value	θ > 10 (rank : 1286)	NC score	0.091796 (rank : 984)
Query Neighborhood Hits	1243	Target Neighborhood Hits	422	Shared Neighborhood Hits	77
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN2_HUMAN
θ value	θ > 10 (rank : 1287)	NC score	0.106467 (rank : 937)
Query Neighborhood Hits	1243	Target Neighborhood Hits	440	Shared Neighborhood Hits	88
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
θ value	θ > 10 (rank : 1288)	NC score	0.106042 (rank : 941)
Query Neighborhood Hits	1243	Target Neighborhood Hits	450	Shared Neighborhood Hits	86
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN3_HUMAN
θ value	θ > 10 (rank : 1289)	NC score	0.102413 (rank : 954)
Query Neighborhood Hits	1243	Target Neighborhood Hits	455	Shared Neighborhood Hits	83
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN3_MOUSE
θ value	θ > 10 (rank : 1290)	NC score	0.095369 (rank : 976)
Query Neighborhood Hits	1243	Target Neighborhood Hits	447	Shared Neighborhood Hits	82
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN4_HUMAN
θ value	θ > 10 (rank : 1291)	NC score	0.094963 (rank : 978)
Query Neighborhood Hits	1243	Target Neighborhood Hits	449	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_MOUSE
θ value	θ > 10 (rank : 1292)	NC score	0.094435 (rank : 979)
Query Neighborhood Hits	1243	Target Neighborhood Hits	445	Shared Neighborhood Hits	77
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN5_HUMAN
θ value	θ > 10 (rank : 1293)	NC score	0.109813 (rank : 927)
Query Neighborhood Hits	1243	Target Neighborhood Hits	446	Shared Neighborhood Hits	86
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTN5_MOUSE
θ value	θ > 10 (rank : 1294)	NC score	0.099790 (rank : 960)
Query Neighborhood Hits	1243	Target Neighborhood Hits	434	Shared Neighborhood Hits	83
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

CNTN6_HUMAN
θ value	θ > 10 (rank : 1295)	NC score	0.088785 (rank : 994)
Query Neighborhood Hits	1243	Target Neighborhood Hits	422	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN6_MOUSE
θ value	θ > 10 (rank : 1296)	NC score	0.088566 (rank : 995)
Query Neighborhood Hits	1243	Target Neighborhood Hits	429	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CO7A1_HUMAN
θ value	θ > 10 (rank : 1297)	NC score	0.055793 (rank : 1125)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	199
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CRKL_HUMAN
θ value	θ > 10 (rank : 1298)	NC score	0.134254 (rank : 873)
Query Neighborhood Hits	1243	Target Neighborhood Hits	313	Shared Neighborhood Hits	62
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1299)	NC score	0.136597 (rank : 871)
Query Neighborhood Hits	1243	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1300)	NC score	0.115051 (rank : 918)
Query Neighborhood Hits	1243	Target Neighborhood Hits	308	Shared Neighborhood Hits	60
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1301)	NC score	0.112481 (rank : 922)
Query Neighborhood Hits	1243	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CSK21_HUMAN
θ value	θ > 10 (rank : 1302)	NC score	0.597836 (rank : 763)
Query Neighborhood Hits	1243	Target Neighborhood Hits	772	Shared Neighborhood Hits	692
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	θ > 10 (rank : 1303)	NC score	0.598825 (rank : 762)
Query Neighborhood Hits	1243	Target Neighborhood Hits	770	Shared Neighborhood Hits	692
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	θ > 10 (rank : 1304)	NC score	0.576849 (rank : 776)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	684
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
θ value	θ > 10 (rank : 1305)	NC score	0.577852 (rank : 774)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	684
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSKI1_HUMAN
θ value	θ > 10 (rank : 1306)	NC score	0.066088 (rank : 1065)
Query Neighborhood Hits	1243	Target Neighborhood Hits	997	Shared Neighborhood Hits	262
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	θ > 10 (rank : 1307)	NC score	0.066384 (rank : 1064)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1031	Shared Neighborhood Hits	270
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKP_HUMAN
θ value	θ > 10 (rank : 1308)	NC score	0.635905 (rank : 729)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1022	Shared Neighborhood Hits	737
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 1309)	NC score	0.637828 (rank : 727)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1027	Shared Neighborhood Hits	738
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DAPP1_HUMAN
θ value	θ > 10 (rank : 1310)	NC score	0.138861 (rank : 869)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1311)	NC score	0.135213 (rank : 872)
Query Neighborhood Hits	1243	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCC_HUMAN
θ value	θ > 10 (rank : 1312)	NC score	0.132853 (rank : 874)
Query Neighborhood Hits	1243	Target Neighborhood Hits	583	Shared Neighborhood Hits	124
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	θ > 10 (rank : 1313)	NC score	0.137070 (rank : 870)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	243
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DGKD_HUMAN
θ value	θ > 10 (rank : 1314)	NC score	0.077772 (rank : 1024)
Query Neighborhood Hits	1243	Target Neighborhood Hits	231	Shared Neighborhood Hits	76
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1315)	NC score	0.068041 (rank : 1056)
Query Neighborhood Hits	1243	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1316)	NC score	0.052811 (rank : 1149)
Query Neighborhood Hits	1243	Target Neighborhood Hits	131	Shared Neighborhood Hits	37
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DNMBP_HUMAN
θ value	θ > 10 (rank : 1317)	NC score	0.061591 (rank : 1087)
Query Neighborhood Hits	1243	Target Neighborhood Hits	413	Shared Neighborhood Hits	65
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 1318)	NC score	0.052240 (rank : 1157)
Query Neighborhood Hits	1243	Target Neighborhood Hits	435	Shared Neighborhood Hits	72
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DSCAM_HUMAN
θ value	θ > 10 (rank : 1319)	NC score	0.125134 (rank : 889)
Query Neighborhood Hits	1243	Target Neighborhood Hits	524	Shared Neighborhood Hits	89
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
θ value	θ > 10 (rank : 1320)	NC score	0.132203 (rank : 876)
Query Neighborhood Hits	1243	Target Neighborhood Hits	589	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DYR1A_HUMAN
θ value	θ > 10 (rank : 1321)	NC score	0.559040 (rank : 783)
Query Neighborhood Hits	1243	Target Neighborhood Hits	764	Shared Neighborhood Hits	682
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 1322)	NC score	0.559026 (rank : 784)
Query Neighborhood Hits	1243	Target Neighborhood Hits	762	Shared Neighborhood Hits	682
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 1323)	NC score	0.576783 (rank : 777)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	714
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYRK4_HUMAN
θ value	θ > 10 (rank : 1324)	NC score	0.541712 (rank : 796)
Query Neighborhood Hits	1243	Target Neighborhood Hits	750	Shared Neighborhood Hits	672
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

ES8L1_HUMAN
θ value	θ > 10 (rank : 1325)	NC score	0.063889 (rank : 1073)
Query Neighborhood Hits	1243	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 1326)	NC score	0.050835 (rank : 1171)
Query Neighborhood Hits	1243	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 1327)	NC score	0.072014 (rank : 1038)
Query Neighborhood Hits	1243	Target Neighborhood Hits	193	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 1328)	NC score	0.072723 (rank : 1037)
Query Neighborhood Hits	1243	Target Neighborhood Hits	169	Shared Neighborhood Hits	43
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 1329)	NC score	0.095632 (rank : 975)
Query Neighborhood Hits	1243	Target Neighborhood Hits	206	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 1330)	NC score	0.078038 (rank : 1021)
Query Neighborhood Hits	1243	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGRL1_HUMAN
θ value	θ > 10 (rank : 1331)	NC score	0.126605 (rank : 884)
Query Neighborhood Hits	1243	Target Neighborhood Hits	335	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

FGRL1_MOUSE
θ value	θ > 10 (rank : 1332)	NC score	0.130330 (rank : 879)
Query Neighborhood Hits	1243	Target Neighborhood Hits	325	Shared Neighborhood Hits	48
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

FINC_HUMAN
θ value	θ > 10 (rank : 1333)	NC score	0.051282 (rank : 1166)
Query Neighborhood Hits	1243	Target Neighborhood Hits	302	Shared Neighborhood Hits	61
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

FINC_MOUSE
θ value	θ > 10 (rank : 1334)	NC score	0.052350 (rank : 1154)
Query Neighborhood Hits	1243	Target Neighborhood Hits	309	Shared Neighborhood Hits	63
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FNDC3_HUMAN
θ value	θ > 10 (rank : 1335)	NC score	0.087855 (rank : 998)
Query Neighborhood Hits	1243	Target Neighborhood Hits	196	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	θ > 10 (rank : 1336)	NC score	0.089708 (rank : 991)
Query Neighborhood Hits	1243	Target Neighborhood Hits	207	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FSTL4_HUMAN
θ value	θ > 10 (rank : 1337)	NC score	0.078424 (rank : 1019)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	47
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL4_MOUSE
θ value	θ > 10 (rank : 1338)	NC score	0.074253 (rank : 1031)
Query Neighborhood Hits	1243	Target Neighborhood Hits	333	Shared Neighborhood Hits	42
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL5_HUMAN
θ value	θ > 10 (rank : 1339)	NC score	0.081759 (rank : 1008)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL5_MOUSE
θ value	θ > 10 (rank : 1340)	NC score	0.077906 (rank : 1022)
Query Neighborhood Hits	1243	Target Neighborhood Hits	355	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1341)	NC score	0.192947 (rank : 855)
Query Neighborhood Hits	1243	Target Neighborhood Hits	304	Shared Neighborhood Hits	63
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1342)	NC score	0.189802 (rank : 858)
Query Neighborhood Hits	1243	Target Neighborhood Hits	297	Shared Neighborhood Hits	61
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1343)	NC score	0.201916 (rank : 849)
Query Neighborhood Hits	1243	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1344)	NC score	0.201761 (rank : 850)
Query Neighborhood Hits	1243	Target Neighborhood Hits	309	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB10_HUMAN
θ value	θ > 10 (rank : 1345)	NC score	0.088820 (rank : 993)
Query Neighborhood Hits	1243	Target Neighborhood Hits	147	Shared Neighborhood Hits	53
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 1346)	NC score	0.090241 (rank : 987)
Query Neighborhood Hits	1243	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 1347)	NC score	0.119824 (rank : 901)
Query Neighborhood Hits	1243	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1348)	NC score	0.127769 (rank : 883)
Query Neighborhood Hits	1243	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1349)	NC score	0.195279 (rank : 853)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	63
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1350)	NC score	0.195174 (rank : 854)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_HUMAN
θ value	θ > 10 (rank : 1351)	NC score	0.105968 (rank : 943)
Query Neighborhood Hits	1243	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 1352)	NC score	0.111372 (rank : 924)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRP3_HUMAN
θ value	θ > 10 (rank : 1353)	NC score	0.070042 (rank : 1049)
Query Neighborhood Hits	1243	Target Neighborhood Hits	131	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GSK3A_HUMAN
θ value	θ > 10 (rank : 1354)	NC score	0.661627 (rank : 696)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	739
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	θ > 10 (rank : 1355)	NC score	0.650968 (rank : 716)
Query Neighborhood Hits	1243	Target Neighborhood Hits	801	Shared Neighborhood Hits	726
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 1356)	NC score	0.650941 (rank : 717)
Query Neighborhood Hits	1243	Target Neighborhood Hits	800	Shared Neighborhood Hits	725
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

HCFC2_MOUSE
θ value	θ > 10 (rank : 1357)	NC score	0.057477 (rank : 1114)
Query Neighborhood Hits	1243	Target Neighborhood Hits	97	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

HIPK4_HUMAN
θ value	θ > 10 (rank : 1358)	NC score	0.643940 (rank : 725)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	716
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

HMCN1_HUMAN
θ value	θ > 10 (rank : 1359)	NC score	0.072957 (rank : 1035)
Query Neighborhood Hits	1243	Target Neighborhood Hits	983	Shared Neighborhood Hits	75
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

HSH2D_HUMAN
θ value	θ > 10 (rank : 1360)	NC score	0.132584 (rank : 875)
Query Neighborhood Hits	1243	Target Neighborhood Hits	159	Shared Neighborhood Hits	46
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 1361)	NC score	0.075582 (rank : 1028)
Query Neighborhood Hits	1243	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IL6RB_HUMAN
θ value	θ > 10 (rank : 1362)	NC score	0.057552 (rank : 1113)
Query Neighborhood Hits	1243	Target Neighborhood Hits	181	Shared Neighborhood Hits	37
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IRAK3_MOUSE
θ value	θ > 10 (rank : 1363)	NC score	0.740004 (rank : 399)
Query Neighborhood Hits	1243	Target Neighborhood Hits	628	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ITB4_HUMAN
θ value	θ > 10 (rank : 1364)	NC score	0.056209 (rank : 1121)
Query Neighborhood Hits	1243	Target Neighborhood Hits	458	Shared Neighborhood Hits	61
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

ITSN1_HUMAN
θ value	θ > 10 (rank : 1365)	NC score	0.059874 (rank : 1099)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1757	Shared Neighborhood Hits	204
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 1366)	NC score	0.060594 (rank : 1094)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1669	Shared Neighborhood Hits	187
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 1367)	NC score	0.062211 (rank : 1082)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1173	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 1368)	NC score	0.057950 (rank : 1111)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1371	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JAM1_HUMAN
θ value	θ > 10 (rank : 1369)	NC score	0.052275 (rank : 1156)
Query Neighborhood Hits	1243	Target Neighborhood Hits	294	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

JAM1_MOUSE
θ value	θ > 10 (rank : 1370)	NC score	0.054164 (rank : 1142)
Query Neighborhood Hits	1243	Target Neighborhood Hits	287	Shared Neighborhood Hits	33
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

JAM2_HUMAN
θ value	θ > 10 (rank : 1371)	NC score	0.071897 (rank : 1040)
Query Neighborhood Hits	1243	Target Neighborhood Hits	304	Shared Neighborhood Hits	42
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

JAM2_MOUSE
θ value	θ > 10 (rank : 1372)	NC score	0.058401 (rank : 1107)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

K2002_HUMAN
θ value	θ > 10 (rank : 1373)	NC score	0.197605 (rank : 852)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	243
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
θ value	θ > 10 (rank : 1374)	NC score	0.165581 (rank : 863)
Query Neighborhood Hits	1243	Target Neighborhood Hits	267	Shared Neighborhood Hits	217
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KAZD1_MOUSE
θ value	θ > 10 (rank : 1375)	NC score	0.051076 (rank : 1168)
Query Neighborhood Hits	1243	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

KC1G1_HUMAN
θ value	θ > 10 (rank : 1376)	NC score	0.507571 (rank : 808)
Query Neighborhood Hits	1243	Target Neighborhood Hits	708	Shared Neighborhood Hits	641
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	θ > 10 (rank : 1377)	NC score	0.509382 (rank : 806)
Query Neighborhood Hits	1243	Target Neighborhood Hits	713	Shared Neighborhood Hits	643
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G2_HUMAN
θ value	θ > 10 (rank : 1378)	NC score	0.474134 (rank : 816)
Query Neighborhood Hits	1243	Target Neighborhood Hits	693	Shared Neighborhood Hits	628
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_MOUSE
θ value	θ > 10 (rank : 1379)	NC score	0.471388 (rank : 818)
Query Neighborhood Hits	1243	Target Neighborhood Hits	695	Shared Neighborhood Hits	627
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	θ > 10 (rank : 1380)	NC score	0.502661 (rank : 809)
Query Neighborhood Hits	1243	Target Neighborhood Hits	711	Shared Neighborhood Hits	643
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KIRR1_HUMAN
θ value	θ > 10 (rank : 1381)	NC score	0.051841 (rank : 1159)
Query Neighborhood Hits	1243	Target Neighborhood Hits	401	Shared Neighborhood Hits	46
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR2_HUMAN
θ value	θ > 10 (rank : 1382)	NC score	0.055605 (rank : 1129)
Query Neighborhood Hits	1243	Target Neighborhood Hits	321	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

KIRR2_MOUSE
θ value	θ > 10 (rank : 1383)	NC score	0.052605 (rank : 1152)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

KPSH2_HUMAN
θ value	θ > 10 (rank : 1384)	NC score	0.703288 (rank : 563)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	735
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

L1CAM_HUMAN
θ value	θ > 10 (rank : 1385)	NC score	0.122342 (rank : 895)
Query Neighborhood Hits	1243	Target Neighborhood Hits	457	Shared Neighborhood Hits	94
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
θ value	θ > 10 (rank : 1386)	NC score	0.116568 (rank : 914)
Query Neighborhood Hits	1243	Target Neighborhood Hits	457	Shared Neighborhood Hits	92
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LCP2_HUMAN
θ value	θ > 10 (rank : 1387)	NC score	0.090726 (rank : 985)
Query Neighborhood Hits	1243	Target Neighborhood Hits	531	Shared Neighborhood Hits	186
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 1388)	NC score	0.068499 (rank : 1055)
Query Neighborhood Hits	1243	Target Neighborhood Hits	177	Shared Neighborhood Hits	61
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 1389)	NC score	0.105856 (rank : 945)
Query Neighborhood Hits	1243	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 1390)	NC score	0.095286 (rank : 977)
Query Neighborhood Hits	1243	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRIG1_HUMAN
θ value	θ > 10 (rank : 1391)	NC score	0.064307 (rank : 1071)
Query Neighborhood Hits	1243	Target Neighborhood Hits	654	Shared Neighborhood Hits	68
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG1_MOUSE
θ value	θ > 10 (rank : 1392)	NC score	0.061603 (rank : 1086)
Query Neighborhood Hits	1243	Target Neighborhood Hits	627	Shared Neighborhood Hits	60
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG2_HUMAN
θ value	θ > 10 (rank : 1393)	NC score	0.061460 (rank : 1088)
Query Neighborhood Hits	1243	Target Neighborhood Hits	595	Shared Neighborhood Hits	60
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

LRIG2_MOUSE
θ value	θ > 10 (rank : 1394)	NC score	0.060225 (rank : 1096)
Query Neighborhood Hits	1243	Target Neighborhood Hits	586	Shared Neighborhood Hits	56
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

LRIG3_HUMAN
θ value	θ > 10 (rank : 1395)	NC score	0.053656 (rank : 1145)
Query Neighborhood Hits	1243	Target Neighborhood Hits	601	Shared Neighborhood Hits	59
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

LRIG3_MOUSE
θ value	θ > 10 (rank : 1396)	NC score	0.054996 (rank : 1136)
Query Neighborhood Hits	1243	Target Neighborhood Hits	611	Shared Neighborhood Hits	57
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

LRRK1_HUMAN
θ value	θ > 10 (rank : 1397)	NC score	0.743762 (rank : 389)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1237	Shared Neighborhood Hits	749
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 1398)	NC score	0.747105 (rank : 377)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1267	Shared Neighborhood Hits	751
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 1399)	NC score	0.710304 (rank : 519)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1382	Shared Neighborhood Hits	754
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 1400)	NC score	0.695205 (rank : 598)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1359	Shared Neighborhood Hits	747
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LSAMP_HUMAN
θ value	θ > 10 (rank : 1401)	NC score	0.097126 (rank : 972)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	49
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_MOUSE
θ value	θ > 10 (rank : 1402)	NC score	0.096023 (rank : 974)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

LU_HUMAN
θ value	θ > 10 (rank : 1403)	NC score	0.063842 (rank : 1074)
Query Neighborhood Hits	1243	Target Neighborhood Hits	283	Shared Neighborhood Hits	44
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

M3K8_HUMAN
θ value	θ > 10 (rank : 1404)	NC score	0.707019 (rank : 541)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	720
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 1405)	NC score	0.704612 (rank : 555)
Query Neighborhood Hits	1243	Target Neighborhood Hits	815	Shared Neighborhood Hits	723
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MAGE1_HUMAN
θ value	θ > 10 (rank : 1406)	NC score	0.055772 (rank : 1127)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1389	Shared Neighborhood Hits	346
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAG_HUMAN
θ value	θ > 10 (rank : 1407)	NC score	0.078996 (rank : 1018)
Query Neighborhood Hits	1243	Target Neighborhood Hits	278	Shared Neighborhood Hits	43
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_MOUSE
θ value	θ > 10 (rank : 1408)	NC score	0.077022 (rank : 1026)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	43
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MALT1_HUMAN
θ value	θ > 10 (rank : 1409)	NC score	0.069145 (rank : 1051)
Query Neighborhood Hits	1243	Target Neighborhood Hits	236	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

MAMC1_HUMAN
θ value	θ > 10 (rank : 1410)	NC score	0.081208 (rank : 1011)
Query Neighborhood Hits	1243	Target Neighborhood Hits	357	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
θ value	θ > 10 (rank : 1411)	NC score	0.080142 (rank : 1016)
Query Neighborhood Hits	1243	Target Neighborhood Hits	357	Shared Neighborhood Hits	50
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MDGA1_HUMAN
θ value	θ > 10 (rank : 1412)	NC score	0.073610 (rank : 1034)
Query Neighborhood Hits	1243	Target Neighborhood Hits	358	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MFA3L_HUMAN
θ value	θ > 10 (rank : 1413)	NC score	0.081497 (rank : 1010)
Query Neighborhood Hits	1243	Target Neighborhood Hits	230	Shared Neighborhood Hits	38
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

MFA3L_MOUSE
θ value	θ > 10 (rank : 1414)	NC score	0.057262 (rank : 1116)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	37
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

MK15_MOUSE
θ value	θ > 10 (rank : 1415)	NC score	0.677734 (rank : 668)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	747
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MKNK1_HUMAN
θ value	θ > 10 (rank : 1416)	NC score	0.516020 (rank : 803)
Query Neighborhood Hits	1243	Target Neighborhood Hits	701	Shared Neighborhood Hits	626
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	θ > 10 (rank : 1417)	NC score	0.642451 (rank : 726)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	740
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	θ > 10 (rank : 1418)	NC score	0.637534 (rank : 728)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	739
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MP2K1_HUMAN
θ value	θ > 10 (rank : 1419)	NC score	0.753818 (rank : 340)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 1420)	NC score	0.754001 (rank : 338)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 1421)	NC score	0.758485 (rank : 308)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	748
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 1422)	NC score	0.756470 (rank : 327)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	747
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MUC18_HUMAN
θ value	θ > 10 (rank : 1423)	NC score	0.051301 (rank : 1165)
Query Neighborhood Hits	1243	Target Neighborhood Hits	275	Shared Neighborhood Hits	39
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

MUC18_MOUSE
θ value	θ > 10 (rank : 1424)	NC score	0.055575 (rank : 1131)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

MYBPH_HUMAN
θ value	θ > 10 (rank : 1425)	NC score	0.065671 (rank : 1066)
Query Neighborhood Hits	1243	Target Neighborhood Hits	256	Shared Neighborhood Hits	74
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

MYBPH_MOUSE
θ value	θ > 10 (rank : 1426)	NC score	0.071280 (rank : 1041)
Query Neighborhood Hits	1243	Target Neighborhood Hits	290	Shared Neighborhood Hits	74
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

MYOM1_HUMAN
θ value	θ > 10 (rank : 1427)	NC score	0.108440 (rank : 933)
Query Neighborhood Hits	1243	Target Neighborhood Hits	405	Shared Neighborhood Hits	86
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
θ value	θ > 10 (rank : 1428)	NC score	0.111329 (rank : 925)
Query Neighborhood Hits	1243	Target Neighborhood Hits	415	Shared Neighborhood Hits	88
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
θ value	θ > 10 (rank : 1429)	NC score	0.104986 (rank : 948)
Query Neighborhood Hits	1243	Target Neighborhood Hits	341	Shared Neighborhood Hits	74
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOTI_HUMAN
θ value	θ > 10 (rank : 1430)	NC score	0.098818 (rank : 964)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
θ value	θ > 10 (rank : 1431)	NC score	0.092541 (rank : 983)
Query Neighborhood Hits	1243	Target Neighborhood Hits	297	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC1_HUMAN
θ value	θ > 10 (rank : 1432)	NC score	0.064439 (rank : 1070)
Query Neighborhood Hits	1243	Target Neighborhood Hits	303	Shared Neighborhood Hits	55
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

MYPC2_HUMAN
θ value	θ > 10 (rank : 1433)	NC score	0.072769 (rank : 1036)
Query Neighborhood Hits	1243	Target Neighborhood Hits	316	Shared Neighborhood Hits	70
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC2_MOUSE
θ value	θ > 10 (rank : 1434)	NC score	0.067175 (rank : 1058)
Query Neighborhood Hits	1243	Target Neighborhood Hits	297	Shared Neighborhood Hits	63
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC3_HUMAN
θ value	θ > 10 (rank : 1435)	NC score	0.093440 (rank : 981)
Query Neighborhood Hits	1243	Target Neighborhood Hits	318	Shared Neighborhood Hits	74
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_MOUSE
θ value	θ > 10 (rank : 1436)	NC score	0.096282 (rank : 973)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	72
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPN_HUMAN
θ value	θ > 10 (rank : 1437)	NC score	0.098052 (rank : 966)
Query Neighborhood Hits	1243	Target Neighborhood Hits	418	Shared Neighborhood Hits	75
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MYPN_MOUSE
θ value	θ > 10 (rank : 1438)	NC score	0.097780 (rank : 968)
Query Neighborhood Hits	1243	Target Neighborhood Hits	421	Shared Neighborhood Hits	74
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NCA11_HUMAN
θ value	θ > 10 (rank : 1439)	NC score	0.109712 (rank : 928)
Query Neighborhood Hits	1243	Target Neighborhood Hits	443	Shared Neighborhood Hits	72
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA11_MOUSE
θ value	θ > 10 (rank : 1440)	NC score	0.106278 (rank : 939)
Query Neighborhood Hits	1243	Target Neighborhood Hits	661	Shared Neighborhood Hits	127
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_HUMAN
θ value	θ > 10 (rank : 1441)	NC score	0.107397 (rank : 935)
Query Neighborhood Hits	1243	Target Neighborhood Hits	437	Shared Neighborhood Hits	73
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA12_MOUSE
θ value	θ > 10 (rank : 1442)	NC score	0.097922 (rank : 967)
Query Neighborhood Hits	1243	Target Neighborhood Hits	399	Shared Neighborhood Hits	63
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCAM2_HUMAN
θ value	θ > 10 (rank : 1443)	NC score	0.117381 (rank : 910)
Query Neighborhood Hits	1243	Target Neighborhood Hits	441	Shared Neighborhood Hits	82
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCAM2_MOUSE
θ value	θ > 10 (rank : 1444)	NC score	0.122040 (rank : 898)
Query Neighborhood Hits	1243	Target Neighborhood Hits	472	Shared Neighborhood Hits	84
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCF1_HUMAN
θ value	θ > 10 (rank : 1445)	NC score	0.055080 (rank : 1134)
Query Neighborhood Hits	1243	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 1446)	NC score	0.054266 (rank : 1141)
Query Neighborhood Hits	1243	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCK1_HUMAN
θ value	θ > 10 (rank : 1447)	NC score	0.190892 (rank : 857)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1448)	NC score	0.190934 (rank : 856)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOA6_HUMAN
θ value	θ > 10 (rank : 1449)	NC score	0.052661 (rank : 1150)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1202	Shared Neighborhood Hits	341
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NEGR1_HUMAN
θ value	θ > 10 (rank : 1450)	NC score	0.086403 (rank : 1000)
Query Neighborhood Hits	1243	Target Neighborhood Hits	346	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NEGR1_MOUSE
θ value	θ > 10 (rank : 1451)	NC score	0.084625 (rank : 1002)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NEO1_HUMAN
θ value	θ > 10 (rank : 1452)	NC score	0.142065 (rank : 867)
Query Neighborhood Hits	1243	Target Neighborhood Hits	530	Shared Neighborhood Hits	102
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 1453)	NC score	0.140677 (rank : 868)
Query Neighborhood Hits	1243	Target Neighborhood Hits	523	Shared Neighborhood Hits	107
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NFASC_HUMAN
θ value	θ > 10 (rank : 1454)	NC score	0.116374 (rank : 915)
Query Neighborhood Hits	1243	Target Neighborhood Hits	497	Shared Neighborhood Hits	101
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	θ > 10 (rank : 1455)	NC score	0.106224 (rank : 940)
Query Neighborhood Hits	1243	Target Neighborhood Hits	475	Shared Neighborhood Hits	95
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NPHN_HUMAN
θ value	θ > 10 (rank : 1456)	NC score	0.070355 (rank : 1045)
Query Neighborhood Hits	1243	Target Neighborhood Hits	362	Shared Neighborhood Hits	59
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NPHN_MOUSE
θ value	θ > 10 (rank : 1457)	NC score	0.064780 (rank : 1068)
Query Neighborhood Hits	1243	Target Neighborhood Hits	370	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NPHP1_HUMAN
θ value	θ > 10 (rank : 1458)	NC score	0.099376 (rank : 963)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1459)	NC score	0.100927 (rank : 958)
Query Neighborhood Hits	1243	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NPTN_MOUSE
θ value	θ > 10 (rank : 1460)	NC score	0.055593 (rank : 1130)
Query Neighborhood Hits	1243	Target Neighborhood Hits	216	Shared Neighborhood Hits	35
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

NRBP_HUMAN
θ value	θ > 10 (rank : 1461)	NC score	0.473910 (rank : 817)
Query Neighborhood Hits	1243	Target Neighborhood Hits	448	Shared Neighborhood Hits	397
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	θ > 10 (rank : 1462)	NC score	0.475121 (rank : 814)
Query Neighborhood Hits	1243	Target Neighborhood Hits	442	Shared Neighborhood Hits	392
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

NRCAM_HUMAN
θ value	θ > 10 (rank : 1463)	NC score	0.119056 (rank : 905)
Query Neighborhood Hits	1243	Target Neighborhood Hits	439	Shared Neighborhood Hits	89
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	θ > 10 (rank : 1464)	NC score	0.116795 (rank : 911)
Query Neighborhood Hits	1243	Target Neighborhood Hits	432	Shared Neighborhood Hits	89
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NRG2_HUMAN
θ value	θ > 10 (rank : 1465)	NC score	0.066548 (rank : 1062)
Query Neighborhood Hits	1243	Target Neighborhood Hits	419	Shared Neighborhood Hits	58
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

NRG2_MOUSE
θ value	θ > 10 (rank : 1466)	NC score	0.063225 (rank : 1078)
Query Neighborhood Hits	1243	Target Neighborhood Hits	392	Shared Neighborhood Hits	45
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

NTKL_HUMAN
θ value	θ > 10 (rank : 1467)	NC score	0.207968 (rank : 848)
Query Neighborhood Hits	1243	Target Neighborhood Hits	266	Shared Neighborhood Hits	207
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	θ > 10 (rank : 1468)	NC score	0.277412 (rank : 839)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	272
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

NTRI_HUMAN
θ value	θ > 10 (rank : 1469)	NC score	0.086421 (rank : 999)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NTRI_MOUSE
θ value	θ > 10 (rank : 1470)	NC score	0.087935 (rank : 997)
Query Neighborhood Hits	1243	Target Neighborhood Hits	342	Shared Neighborhood Hits	50
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

OBSL1_HUMAN
θ value	θ > 10 (rank : 1471)	NC score	0.084184 (rank : 1005)
Query Neighborhood Hits	1243	Target Neighborhood Hits	354	Shared Neighborhood Hits	53
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

OPCM_HUMAN
θ value	θ > 10 (rank : 1472)	NC score	0.081142 (rank : 1013)
Query Neighborhood Hits	1243	Target Neighborhood Hits	332	Shared Neighborhood Hits	49
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

OSTF1_HUMAN
θ value	θ > 10 (rank : 1473)	NC score	0.080816 (rank : 1014)
Query Neighborhood Hits	1243	Target Neighborhood Hits	466	Shared Neighborhood Hits	60
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 1474)	NC score	0.073860 (rank : 1032)
Query Neighborhood Hits	1243	Target Neighborhood Hits	467	Shared Neighborhood Hits	60
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 1475)	NC score	0.121354 (rank : 899)
Query Neighborhood Hits	1243	Target Neighborhood Hits	451	Shared Neighborhood Hits	64
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1476)	NC score	0.119368 (rank : 903)
Query Neighborhood Hits	1243	Target Neighborhood Hits	401	Shared Neighborhood Hits	64
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1477)	NC score	0.101205 (rank : 957)
Query Neighborhood Hits	1243	Target Neighborhood Hits	479	Shared Neighborhood Hits	67
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1478)	NC score	0.102561 (rank : 952)
Query Neighborhood Hits	1243	Target Neighborhood Hits	435	Shared Neighborhood Hits	65
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1479)	NC score	0.116747 (rank : 912)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	91
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1480)	NC score	0.120805 (rank : 900)
Query Neighborhood Hits	1243	Target Neighborhood Hits	519	Shared Neighborhood Hits	80
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 1481)	NC score	0.061211 (rank : 1091)
Query Neighborhood Hits	1243	Target Neighborhood Hits	320	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 1482)	NC score	0.059272 (rank : 1103)
Query Neighborhood Hits	1243	Target Neighborhood Hits	283	Shared Neighborhood Hits	43
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 1483)	NC score	0.059991 (rank : 1098)
Query Neighborhood Hits	1243	Target Neighborhood Hits	339	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 1484)	NC score	0.060212 (rank : 1097)
Query Neighborhood Hits	1243	Target Neighborhood Hits	382	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 1485)	NC score	0.058618 (rank : 1106)
Query Neighborhood Hits	1243	Target Neighborhood Hits	385	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 1486)	NC score	0.055719 (rank : 1128)
Query Neighborhood Hits	1243	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PDZD8_HUMAN
θ value	θ > 10 (rank : 1487)	NC score	0.053094 (rank : 1147)
Query Neighborhood Hits	1243	Target Neighborhood Hits	185	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PGBM_HUMAN
θ value	θ > 10 (rank : 1488)	NC score	0.068607 (rank : 1054)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1113	Shared Neighborhood Hits	112
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PGBM_MOUSE
θ value	θ > 10 (rank : 1489)	NC score	0.069567 (rank : 1050)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1073	Shared Neighborhood Hits	102
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PGFRL_HUMAN
θ value	θ > 10 (rank : 1490)	NC score	0.114644 (rank : 919)
Query Neighborhood Hits	1243	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PGFRL_MOUSE
θ value	θ > 10 (rank : 1491)	NC score	0.119177 (rank : 904)
Query Neighborhood Hits	1243	Target Neighborhood Hits	106	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PI3R4_HUMAN
θ value	θ > 10 (rank : 1492)	NC score	0.218499 (rank : 847)
Query Neighborhood Hits	1243	Target Neighborhood Hits	534	Shared Neighborhood Hits	336
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	θ > 10 (rank : 1493)	NC score	0.228266 (rank : 846)
Query Neighborhood Hits	1243	Target Neighborhood Hits	535	Shared Neighborhood Hits	343
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PLCG1_HUMAN
θ value	θ > 10 (rank : 1494)	NC score	0.124169 (rank : 892)
Query Neighborhood Hits	1243	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 1495)	NC score	0.124222 (rank : 891)
Query Neighborhood Hits	1243	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 1496)	NC score	0.123405 (rank : 893)
Query Neighborhood Hits	1243	Target Neighborhood Hits	280	Shared Neighborhood Hits	54
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PMYT1_HUMAN
θ value	θ > 10 (rank : 1497)	NC score	0.676571 (rank : 670)
Query Neighborhood Hits	1243	Target Neighborhood Hits	814	Shared Neighborhood Hits	733
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PPIP1_HUMAN
θ value	θ > 10 (rank : 1498)	NC score	0.067137 (rank : 1059)
Query Neighborhood Hits	1243	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 1499)	NC score	0.063336 (rank : 1077)
Query Neighborhood Hits	1243	Target Neighborhood Hits	377	Shared Neighborhood Hits	58
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRP4B_HUMAN
θ value	θ > 10 (rank : 1500)	NC score	0.606560 (rank : 754)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1030	Shared Neighborhood Hits	710
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 1501)	NC score	0.605230 (rank : 755)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1040	Shared Neighborhood Hits	708
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PRPK_HUMAN
θ value	θ > 10 (rank : 1502)	NC score	0.117897 (rank : 908)
Query Neighborhood Hits	1243	Target Neighborhood Hits	131	Shared Neighborhood Hits	124
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1503)	NC score	0.124587 (rank : 890)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	128
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PTN11_HUMAN
θ value	θ > 10 (rank : 1504)	NC score	0.084197 (rank : 1004)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 1505)	NC score	0.084264 (rank : 1003)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 1506)	NC score	0.062554 (rank : 1080)
Query Neighborhood Hits	1243	Target Neighborhood Hits	234	Shared Neighborhood Hits	47
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 1507)	NC score	0.067053 (rank : 1060)
Query Neighborhood Hits	1243	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTPRD_HUMAN
θ value	θ > 10 (rank : 1508)	NC score	0.109146 (rank : 929)
Query Neighborhood Hits	1243	Target Neighborhood Hits	485	Shared Neighborhood Hits	94
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 1509)	NC score	0.109114 (rank : 930)
Query Neighborhood Hits	1243	Target Neighborhood Hits	491	Shared Neighborhood Hits	92
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
θ value	θ > 10 (rank : 1510)	NC score	0.107517 (rank : 934)
Query Neighborhood Hits	1243	Target Neighborhood Hits	489	Shared Neighborhood Hits	95
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRS_HUMAN
θ value	θ > 10 (rank : 1511)	NC score	0.107304 (rank : 936)
Query Neighborhood Hits	1243	Target Neighborhood Hits	472	Shared Neighborhood Hits	94
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRU_HUMAN
θ value	θ > 10 (rank : 1512)	NC score	0.051552 (rank : 1162)
Query Neighborhood Hits	1243	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PUNC_HUMAN
θ value	θ > 10 (rank : 1513)	NC score	0.103703 (rank : 950)
Query Neighborhood Hits	1243	Target Neighborhood Hits	449	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
θ value	θ > 10 (rank : 1514)	NC score	0.101460 (rank : 955)
Query Neighborhood Hits	1243	Target Neighborhood Hits	501	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PXK_HUMAN
θ value	θ > 10 (rank : 1515)	NC score	0.105961 (rank : 944)
Query Neighborhood Hits	1243	Target Neighborhood Hits	216	Shared Neighborhood Hits	134
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RAGE_HUMAN
θ value	θ > 10 (rank : 1516)	NC score	0.059045 (rank : 1104)
Query Neighborhood Hits	1243	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RAGE_MOUSE
θ value	θ > 10 (rank : 1517)	NC score	0.055133 (rank : 1133)
Query Neighborhood Hits	1243	Target Neighborhood Hits	295	Shared Neighborhood Hits	39
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RASA1_HUMAN
θ value	θ > 10 (rank : 1518)	NC score	0.154405 (rank : 865)
Query Neighborhood Hits	1243	Target Neighborhood Hits	258	Shared Neighborhood Hits	63
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_MOUSE
θ value	θ > 10 (rank : 1519)	NC score	0.052996 (rank : 1148)
Query Neighborhood Hits	1243	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RN5A_HUMAN
θ value	θ > 10 (rank : 1520)	NC score	0.112700 (rank : 920)
Query Neighborhood Hits	1243	Target Neighborhood Hits	608	Shared Neighborhood Hits	312
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RN5A_MOUSE
θ value	θ > 10 (rank : 1521)	NC score	0.282519 (rank : 838)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	579
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ROBO1_HUMAN
θ value	θ > 10 (rank : 1522)	NC score	0.118646 (rank : 906)
Query Neighborhood Hits	1243	Target Neighborhood Hits	529	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
θ value	θ > 10 (rank : 1523)	NC score	0.119706 (rank : 902)
Query Neighborhood Hits	1243	Target Neighborhood Hits	559	Shared Neighborhood Hits	108
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO2_HUMAN
θ value	θ > 10 (rank : 1524)	NC score	0.115854 (rank : 916)
Query Neighborhood Hits	1243	Target Neighborhood Hits	479	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
θ value	θ > 10 (rank : 1525)	NC score	0.116709 (rank : 913)
Query Neighborhood Hits	1243	Target Neighborhood Hits	504	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_MOUSE
θ value	θ > 10 (rank : 1526)	NC score	0.110364 (rank : 926)
Query Neighborhood Hits	1243	Target Neighborhood Hits	524	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

ROBO4_HUMAN
θ value	θ > 10 (rank : 1527)	NC score	0.073742 (rank : 1033)
Query Neighborhood Hits	1243	Target Neighborhood Hits	364	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

ROBO4_MOUSE
θ value	θ > 10 (rank : 1528)	NC score	0.080416 (rank : 1015)
Query Neighborhood Hits	1243	Target Neighborhood Hits	358	Shared Neighborhood Hits	68
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

RPKL1_HUMAN
θ value	θ > 10 (rank : 1529)	NC score	0.496823 (rank : 811)
Query Neighborhood Hits	1243	Target Neighborhood Hits	708	Shared Neighborhood Hits	626
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 1530)	NC score	0.501746 (rank : 810)
Query Neighborhood Hits	1243	Target Neighborhood Hits	704	Shared Neighborhood Hits	622
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 1531)	NC score	0.466738 (rank : 819)
Query Neighborhood Hits	1243	Target Neighborhood Hits	632	Shared Neighborhood Hits	532
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1532)	NC score	0.449656 (rank : 823)
Query Neighborhood Hits	1243	Target Neighborhood Hits	603	Shared Neighborhood Hits	510
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SDK1_HUMAN
θ value	θ > 10 (rank : 1533)	NC score	0.129060 (rank : 882)
Query Neighborhood Hits	1243	Target Neighborhood Hits	511	Shared Neighborhood Hits	105
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	θ > 10 (rank : 1534)	NC score	0.125618 (rank : 887)
Query Neighborhood Hits	1243	Target Neighborhood Hits	495	Shared Neighborhood Hits	100
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	θ > 10 (rank : 1535)	NC score	0.125903 (rank : 886)
Query Neighborhood Hits	1243	Target Neighborhood Hits	495	Shared Neighborhood Hits	94
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	θ > 10 (rank : 1536)	NC score	0.122057 (rank : 897)
Query Neighborhood Hits	1243	Target Neighborhood Hits	480	Shared Neighborhood Hits	92
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SH21A_HUMAN
θ value	θ > 10 (rank : 1537)	NC score	0.157453 (rank : 864)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1538)	NC score	0.168971 (rank : 861)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1539)	NC score	0.167231 (rank : 862)
Query Neighborhood Hits	1243	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1540)	NC score	0.185900 (rank : 860)
Query Neighborhood Hits	1243	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 1541)	NC score	0.054599 (rank : 1138)
Query Neighborhood Hits	1243	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 1542)	NC score	0.070105 (rank : 1048)
Query Neighborhood Hits	1243	Target Neighborhood Hits	179	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 1543)	NC score	0.065134 (rank : 1067)
Query Neighborhood Hits	1243	Target Neighborhood Hits	149	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 1544)	NC score	0.099590 (rank : 962)
Query Neighborhood Hits	1243	Target Neighborhood Hits	455	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 1545)	NC score	0.070725 (rank : 1044)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 1546)	NC score	0.075025 (rank : 1029)
Query Neighborhood Hits	1243	Target Neighborhood Hits	188	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 1547)	NC score	0.076693 (rank : 1027)
Query Neighborhood Hits	1243	Target Neighborhood Hits	174	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 1548)	NC score	0.104082 (rank : 949)
Query Neighborhood Hits	1243	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 1549)	NC score	0.109037 (rank : 931)
Query Neighborhood Hits	1243	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 1550)	NC score	0.106030 (rank : 942)
Query Neighborhood Hits	1243	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 1551)	NC score	0.105293 (rank : 947)
Query Neighborhood Hits	1243	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 1552)	NC score	0.105695 (rank : 946)
Query Neighborhood Hits	1243	Target Neighborhood Hits	170	Shared Neighborhood Hits	57
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 1553)	NC score	0.097527 (rank : 970)
Query Neighborhood Hits	1243	Target Neighborhood Hits	144	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 1554)	NC score	0.089827 (rank : 989)
Query Neighborhood Hits	1243	Target Neighborhood Hits	155	Shared Neighborhood Hits	44
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 1555)	NC score	0.097251 (rank : 971)
Query Neighborhood Hits	1243	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 1556)	NC score	0.098408 (rank : 965)
Query Neighborhood Hits	1243	Target Neighborhood Hits	204	Shared Neighborhood Hits	60
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 1557)	NC score	0.102450 (rank : 953)
Query Neighborhood Hits	1243	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 1558)	NC score	0.129836 (rank : 881)
Query Neighborhood Hits	1243	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 1559)	NC score	0.130234 (rank : 880)
Query Neighborhood Hits	1243	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SIG10_HUMAN
θ value	θ > 10 (rank : 1560)	NC score	0.057060 (rank : 1117)
Query Neighborhood Hits	1243	Target Neighborhood Hits	363	Shared Neighborhood Hits	79
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

SIG11_HUMAN
θ value	θ > 10 (rank : 1561)	NC score	0.054066 (rank : 1143)
Query Neighborhood Hits	1243	Target Neighborhood Hits	273	Shared Neighborhood Hits	44
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

SLAP1_HUMAN
θ value	θ > 10 (rank : 1562)	NC score	0.264015 (rank : 842)
Query Neighborhood Hits	1243	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1563)	NC score	0.260401 (rank : 843)
Query Neighborhood Hits	1243	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1564)	NC score	0.268394 (rank : 841)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1565)	NC score	0.276373 (rank : 840)
Query Neighborhood Hits	1243	Target Neighborhood Hits	136	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SN_HUMAN
θ value	θ > 10 (rank : 1566)	NC score	0.062645 (rank : 1079)
Query Neighborhood Hits	1243	Target Neighborhood Hits	434	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

SN_MOUSE
θ value	θ > 10 (rank : 1567)	NC score	0.062426 (rank : 1081)
Query Neighborhood Hits	1243	Target Neighborhood Hits	416	Shared Neighborhood Hits	52
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

SOCS6_HUMAN
θ value	θ > 10 (rank : 1568)	NC score	0.056182 (rank : 1122)
Query Neighborhood Hits	1243	Target Neighborhood Hits	126	Shared Neighborhood Hits	30
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 1569)	NC score	0.055923 (rank : 1123)
Query Neighborhood Hits	1243	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SPN90_HUMAN
θ value	θ > 10 (rank : 1570)	NC score	0.101253 (rank : 956)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 1571)	NC score	0.093814 (rank : 980)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 1572)	NC score	0.051056 (rank : 1169)
Query Neighborhood Hits	1243	Target Neighborhood Hits	396	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRPK1_HUMAN
θ value	θ > 10 (rank : 1573)	NC score	0.323367 (rank : 832)
Query Neighborhood Hits	1243	Target Neighborhood Hits	706	Shared Neighborhood Hits	526
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	θ > 10 (rank : 1574)	NC score	0.323479 (rank : 831)
Query Neighborhood Hits	1243	Target Neighborhood Hits	639	Shared Neighborhood Hits	508
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
θ value	θ > 10 (rank : 1575)	NC score	0.310833 (rank : 835)
Query Neighborhood Hits	1243	Target Neighborhood Hits	664	Shared Neighborhood Hits	510
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	θ > 10 (rank : 1576)	NC score	0.309348 (rank : 836)
Query Neighborhood Hits	1243	Target Neighborhood Hits	765	Shared Neighborhood Hits	522
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STAC3_HUMAN
θ value	θ > 10 (rank : 1577)	NC score	0.126465 (rank : 885)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	75
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1578)	NC score	0.125530 (rank : 888)
Query Neighborhood Hits	1243	Target Neighborhood Hits	232	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1579)	NC score	0.108773 (rank : 932)
Query Neighborhood Hits	1243	Target Neighborhood Hits	276	Shared Neighborhood Hits	84
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1580)	NC score	0.118313 (rank : 907)
Query Neighborhood Hits	1243	Target Neighborhood Hits	268	Shared Neighborhood Hits	83
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 1581)	NC score	0.067941 (rank : 1057)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	53
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 1582)	NC score	0.068868 (rank : 1053)
Query Neighborhood Hits	1243	Target Neighborhood Hits	273	Shared Neighborhood Hits	50
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 1583)	NC score	0.070156 (rank : 1047)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 1584)	NC score	0.074440 (rank : 1030)
Query Neighborhood Hits	1243	Target Neighborhood Hits	285	Shared Neighborhood Hits	47
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STK23_HUMAN
θ value	θ > 10 (rank : 1585)	NC score	0.313683 (rank : 834)
Query Neighborhood Hits	1243	Target Neighborhood Hits	556	Shared Neighborhood Hits	494
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	θ > 10 (rank : 1586)	NC score	0.315131 (rank : 833)
Query Neighborhood Hits	1243	Target Neighborhood Hits	572	Shared Neighborhood Hits	499
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK31_HUMAN
θ value	θ > 10 (rank : 1587)	NC score	0.284746 (rank : 837)
Query Neighborhood Hits	1243	Target Neighborhood Hits	570	Shared Neighborhood Hits	349
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

STK31_MOUSE
θ value	θ > 10 (rank : 1588)	NC score	0.233002 (rank : 845)
Query Neighborhood Hits	1243	Target Neighborhood Hits	474	Shared Neighborhood Hits	287
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

STK40_HUMAN
θ value	θ > 10 (rank : 1589)	NC score	0.584204 (rank : 770)
Query Neighborhood Hits	1243	Target Neighborhood Hits	751	Shared Neighborhood Hits	675
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 1590)	NC score	0.583872 (rank : 771)
Query Neighborhood Hits	1243	Target Neighborhood Hits	751	Shared Neighborhood Hits	676
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

TARSH_HUMAN
θ value	θ > 10 (rank : 1591)	NC score	0.081206 (rank : 1012)
Query Neighborhood Hits	1243	Target Neighborhood Hits	768	Shared Neighborhood Hits	227
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TENS4_HUMAN
θ value	θ > 10 (rank : 1592)	NC score	0.054719 (rank : 1137)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 1593)	NC score	0.066424 (rank : 1063)
Query Neighborhood Hits	1243	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 1594)	NC score	0.633446 (rank : 730)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1103	Shared Neighborhood Hits	581
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TITIN_HUMAN
θ value	θ > 10 (rank : 1595)	NC score	0.545024 (rank : 792)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2923	Shared Neighborhood Hits	857
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TLK1_HUMAN
θ value	θ > 10 (rank : 1596)	NC score	0.670800 (rank : 680)
Query Neighborhood Hits	1243	Target Neighborhood Hits	967	Shared Neighborhood Hits	715
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 1597)	NC score	0.670060 (rank : 684)
Query Neighborhood Hits	1243	Target Neighborhood Hits	947	Shared Neighborhood Hits	710
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 1598)	NC score	0.679701 (rank : 660)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1044	Shared Neighborhood Hits	727
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 1599)	NC score	0.677948 (rank : 666)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1088	Shared Neighborhood Hits	730
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TMIGD_HUMAN
θ value	θ > 10 (rank : 1600)	NC score	0.089807 (rank : 990)
Query Neighborhood Hits	1243	Target Neighborhood Hits	240	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TMIGD_MOUSE
θ value	θ > 10 (rank : 1601)	NC score	0.082109 (rank : 1007)
Query Neighborhood Hits	1243	Target Neighborhood Hits	234	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TRIB3_HUMAN
θ value	θ > 10 (rank : 1602)	NC score	0.443289 (rank : 824)
Query Neighborhood Hits	1243	Target Neighborhood Hits	519	Shared Neighborhood Hits	482
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TTBK1_HUMAN
θ value	θ > 10 (rank : 1603)	NC score	0.562455 (rank : 782)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1058	Shared Neighborhood Hits	699
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 1604)	NC score	0.541268 (rank : 798)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	647
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 1605)	NC score	0.541416 (rank : 797)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	643
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

UN13A_HUMAN
θ value	θ > 10 (rank : 1606)	NC score	0.051376 (rank : 1164)
Query Neighborhood Hits	1243	Target Neighborhood Hits	285	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1607)	NC score	0.050339 (rank : 1175)
Query Neighborhood Hits	1243	Target Neighborhood Hits	217	Shared Neighborhood Hits	45
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

USH2A_HUMAN
θ value	θ > 10 (rank : 1608)	NC score	0.055142 (rank : 1132)
Query Neighborhood Hits	1243	Target Neighborhood Hits	600	Shared Neighborhood Hits	69
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	θ > 10 (rank : 1609)	NC score	0.055775 (rank : 1126)
Query Neighborhood Hits	1243	Target Neighborhood Hits	626	Shared Neighborhood Hits	88
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VAV2_HUMAN
θ value	θ > 10 (rank : 1610)	NC score	0.122287 (rank : 896)
Query Neighborhood Hits	1243	Target Neighborhood Hits	453	Shared Neighborhood Hits	101
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1611)	NC score	0.117813 (rank : 909)
Query Neighborhood Hits	1243	Target Neighborhood Hits	456	Shared Neighborhood Hits	108
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1612)	NC score	0.131693 (rank : 878)
Query Neighborhood Hits	1243	Target Neighborhood Hits	398	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1613)	NC score	0.131983 (rank : 877)
Query Neighborhood Hits	1243	Target Neighborhood Hits	404	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1614)	NC score	0.122594 (rank : 894)
Query Neighborhood Hits	1243	Target Neighborhood Hits	452	Shared Neighborhood Hits	96
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1615)	NC score	0.112583 (rank : 921)
Query Neighborhood Hits	1243	Target Neighborhood Hits	430	Shared Neighborhood Hits	92
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VCAM1_HUMAN
θ value	θ > 10 (rank : 1616)	NC score	0.057953 (rank : 1110)
Query Neighborhood Hits	1243	Target Neighborhood Hits	352	Shared Neighborhood Hits	40
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

VCAM1_MOUSE
θ value	θ > 10 (rank : 1617)	NC score	0.061249 (rank : 1090)
Query Neighborhood Hits	1243	Target Neighborhood Hits	320	Shared Neighborhood Hits	40
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

VINEX_HUMAN
θ value	θ > 10 (rank : 1618)	NC score	0.057039 (rank : 1118)
Query Neighborhood Hits	1243	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 1619)	NC score	0.060620 (rank : 1093)
Query Neighborhood Hits	1243	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VRK1_HUMAN
θ value	θ > 10 (rank : 1620)	NC score	0.359411 (rank : 829)
Query Neighborhood Hits	1243	Target Neighborhood Hits	584	Shared Neighborhood Hits	536
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
θ value	θ > 10 (rank : 1621)	NC score	0.368605 (rank : 828)
Query Neighborhood Hits	1243	Target Neighborhood Hits	583	Shared Neighborhood Hits	532
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK3_MOUSE
θ value	θ > 10 (rank : 1622)	NC score	0.201430 (rank : 851)
Query Neighborhood Hits	1243	Target Neighborhood Hits	342	Shared Neighborhood Hits	291
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WNK1_HUMAN
θ value	θ > 10 (rank : 1623)	NC score	0.721913 (rank : 477)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1158	Shared Neighborhood Hits	777
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 1624)	NC score	0.721206 (rank : 481)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1179	Shared Neighborhood Hits	783
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK3_HUMAN
θ value	θ > 10 (rank : 1625)	NC score	0.720093 (rank : 485)
Query Neighborhood Hits	1243	Target Neighborhood Hits	948	Shared Neighborhood Hits	728
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

Hits sorted by NC score

AATK_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1243	Shared Neighborhood Hits	1243
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
NC score	0.976653 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	1243	Target Neighborhood Hits	942	Shared Neighborhood Hits	810
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

RET_HUMAN
NC score	0.931783 (rank : 3)	θ value	1.73987e-27 (rank : 55)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	746
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
NC score	0.931099 (rank : 4)	θ value	1.02001e-27 (rank : 52)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	747
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

INSR_HUMAN
NC score	0.930358 (rank : 5)	θ value	7.27602e-42 (rank : 4)
Query Neighborhood Hits	1243	Target Neighborhood Hits	963	Shared Neighborhood Hits	749
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
NC score	0.928931 (rank : 6)	θ value	3.05695e-40 (rank : 5)
Query Neighborhood Hits	1243	Target Neighborhood Hits	968	Shared Neighborhood Hits	746
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

FAK1_HUMAN
NC score	0.928755 (rank : 7)	θ value	1.5242e-23 (rank : 94)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	763
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FES_MOUSE
NC score	0.928744 (rank : 8)	θ value	1.6813e-30 (rank : 30)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	753
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FAK1_MOUSE
NC score	0.928623 (rank : 9)	θ value	1.5242e-23 (rank : 95)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	760
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FES_HUMAN
NC score	0.928412 (rank : 10)	θ value	4.42448e-31 (rank : 28)
Query Neighborhood Hits	1243	Target Neighborhood Hits	978	Shared Neighborhood Hits	751
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

STYK1_HUMAN
NC score	0.927309 (rank : 11)	θ value	2.77775e-25 (rank : 77)
Query Neighborhood Hits	1243	Target Neighborhood Hits	786	Shared Neighborhood Hits	723
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

BMX_MOUSE
NC score	0.927023 (rank : 12)	θ value	1.52067e-31 (rank : 26)
Query Neighborhood Hits	1243	Target Neighborhood Hits	912	Shared Neighborhood Hits	741
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

IGF1R_MOUSE
NC score	0.926767 (rank : 13)	θ value	3.73686e-38 (rank : 9)
Query Neighborhood Hits	1243	Target Neighborhood Hits	973	Shared Neighborhood Hits	743
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_MOUSE
NC score	0.926302 (rank : 14)	θ value	2.67802e-36 (rank : 15)
Query Neighborhood Hits	1243	Target Neighborhood Hits	961	Shared Neighborhood Hits	739
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

STYK1_MOUSE
NC score	0.926285 (rank : 15)	θ value	9.54697e-26 (rank : 75)
Query Neighborhood Hits	1243	Target Neighborhood Hits	779	Shared Neighborhood Hits	722
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

BMX_HUMAN
NC score	0.926161 (rank : 16)	θ value	5.22648e-32 (rank : 23)
Query Neighborhood Hits	1243	Target Neighborhood Hits	942	Shared Neighborhood Hits	745
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

IGF1R_HUMAN
NC score	0.926160 (rank : 17)	θ value	2.86122e-38 (rank : 8)
Query Neighborhood Hits	1243	Target Neighborhood Hits	977	Shared Neighborhood Hits	742
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ACK1_MOUSE
NC score	0.925925 (rank : 18)	θ value	8.63488e-27 (rank : 62)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1080	Shared Neighborhood Hits	844
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

FAK2_HUMAN
NC score	0.925915 (rank : 19)	θ value	2.97466e-19 (rank : 134)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	746
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
NC score	0.925447 (rank : 20)	θ value	6.62687e-19 (rank : 139)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	745
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ACK1_HUMAN
NC score	0.925079 (rank : 21)	θ value	3.28125e-26 (rank : 67)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1140	Shared Neighborhood Hits	865
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

INSRR_HUMAN
NC score	0.924711 (rank : 22)	θ value	1.32909e-35 (rank : 17)
Query Neighborhood Hits	1243	Target Neighborhood Hits	950	Shared Neighborhood Hits	742
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ALK_MOUSE
NC score	0.924062 (rank : 23)	θ value	1.42001e-37 (rank : 10)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	710
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

NTRK1_HUMAN
NC score	0.923718 (rank : 24)	θ value	3.27365e-34 (rank : 19)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1023	Shared Neighborhood Hits	743
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

ALK_HUMAN
NC score	0.923552 (rank : 25)	θ value	2.42216e-37 (rank : 11)
Query Neighborhood Hits	1243	Target Neighborhood Hits	795	Shared Neighborhood Hits	700
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_HUMAN
NC score	0.922134 (rank : 26)	θ value	7.79185e-36 (rank : 16)
Query Neighborhood Hits	1243	Target Neighborhood Hits	774	Shared Neighborhood Hits	702
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MATK_HUMAN
NC score	0.922104 (rank : 27)	θ value	5.42112e-21 (rank : 110)
Query Neighborhood Hits	1243	Target Neighborhood Hits	954	Shared Neighborhood Hits	760
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

TNK1_HUMAN
NC score	0.921739 (rank : 28)	θ value	1.99529e-15 (rank : 164)
Query Neighborhood Hits	1243	Target Neighborhood Hits	815	Shared Neighborhood Hits	741
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

RON_MOUSE
NC score	0.921412 (rank : 29)	θ value	2.27234e-27 (rank : 57)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROS_HUMAN
NC score	0.921199 (rank : 30)	θ value	9.20422e-37 (rank : 14)
Query Neighborhood Hits	1243	Target Neighborhood Hits	907	Shared Neighborhood Hits	721
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

SRMS_MOUSE
NC score	0.921120 (rank : 31)	θ value	3.62785e-25 (rank : 78)
Query Neighborhood Hits	1243	Target Neighborhood Hits	964	Shared Neighborhood Hits	757
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TXK_MOUSE
NC score	0.921057 (rank : 32)	θ value	3.17079e-29 (rank : 42)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	755
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SRMS_HUMAN
NC score	0.921030 (rank : 33)	θ value	7.56453e-23 (rank : 97)
Query Neighborhood Hits	1243	Target Neighborhood Hits	946	Shared Neighborhood Hits	756
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

MATK_MOUSE
NC score	0.920942 (rank : 34)	θ value	1.2077e-20 (rank : 115)
Query Neighborhood Hits	1243	Target Neighborhood Hits	952	Shared Neighborhood Hits	759
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

LTK_MOUSE
NC score	0.920562 (rank : 35)	θ value	8.06329e-33 (rank : 21)
Query Neighborhood Hits	1243	Target Neighborhood Hits	770	Shared Neighborhood Hits	702
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ITK_MOUSE
NC score	0.920533 (rank : 36)	θ value	3.50572e-28 (rank : 49)
Query Neighborhood Hits	1243	Target Neighborhood Hits	985	Shared Neighborhood Hits	759
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

RON_HUMAN
NC score	0.920528 (rank : 37)	θ value	3.28125e-26 (rank : 68)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	750
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TXK_HUMAN
NC score	0.920440 (rank : 38)	θ value	2.19584e-30 (rank : 31)
Query Neighborhood Hits	1243	Target Neighborhood Hits	971	Shared Neighborhood Hits	753
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

DDR1_MOUSE
NC score	0.920288 (rank : 39)	θ value	3.74554e-30 (rank : 32)
Query Neighborhood Hits	1243	Target Neighborhood Hits	818	Shared Neighborhood Hits	730
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

MET_MOUSE
NC score	0.920108 (rank : 40)	θ value	8.3442e-30 (rank : 37)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	743
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ITK_HUMAN
NC score	0.919587 (rank : 41)	θ value	2.27234e-27 (rank : 56)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1016	Shared Neighborhood Hits	759
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MET_HUMAN
NC score	0.919031 (rank : 42)	θ value	1.85889e-29 (rank : 40)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	742
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

TEC_HUMAN
NC score	0.918865 (rank : 43)	θ value	1.28732e-30 (rank : 29)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1006	Shared Neighborhood Hits	760
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
NC score	0.918805 (rank : 44)	θ value	4.89182e-30 (rank : 36)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1006	Shared Neighborhood Hits	760
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

DDR2_MOUSE
NC score	0.918652 (rank : 45)	θ value	5.39604e-37 (rank : 12)
Query Neighborhood Hits	1243	Target Neighborhood Hits	813	Shared Neighborhood Hits	730
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR1_HUMAN
NC score	0.918596 (rank : 46)	θ value	2.42779e-29 (rank : 41)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	731
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

TNK1_MOUSE
NC score	0.918309 (rank : 47)	θ value	1.42992e-13 (rank : 176)
Query Neighborhood Hits	1243	Target Neighborhood Hits	806	Shared Neighborhood Hits	736
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

DDR2_HUMAN
NC score	0.918259 (rank : 48)	θ value	9.20422e-37 (rank : 13)
Query Neighborhood Hits	1243	Target Neighborhood Hits	818	Shared Neighborhood Hits	730
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ZAP70_HUMAN
NC score	0.916933 (rank : 49)	θ value	1.5773e-20 (rank : 117)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	751
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
NC score	0.916846 (rank : 50)	θ value	1.02238e-19 (rank : 125)
Query Neighborhood Hits	1243	Target Neighborhood Hits	905	Shared Neighborhood Hits	753
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CSK_HUMAN
NC score	0.916714 (rank : 51)	θ value	3.07116e-24 (rank : 86)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	761
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

RYK_MOUSE
NC score	0.916675 (rank : 52)	θ value	3.74554e-30 (rank : 34)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	672
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ABL1_MOUSE
NC score	0.916170 (rank : 53)	θ value	1.52067e-31 (rank : 25)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1178	Shared Neighborhood Hits	812
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.915939 (rank : 54)	θ value	9.2256e-29 (rank : 45)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1045	Shared Neighborhood Hits	770
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

FRK_HUMAN
NC score	0.915769 (rank : 55)	θ value	1.73987e-27 (rank : 54)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1058	Shared Neighborhood Hits	763
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ABL1_HUMAN
NC score	0.915294 (rank : 56)	θ value	1.08979e-29 (rank : 38)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1220	Shared Neighborhood Hits	820
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

KSYK_HUMAN
NC score	0.915150 (rank : 57)	θ value	1.42661e-21 (rank : 106)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	756
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
NC score	0.914631 (rank : 58)	θ value	9.24701e-21 (rank : 112)
Query Neighborhood Hits	1243	Target Neighborhood Hits	944	Shared Neighborhood Hits	770
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CSK_MOUSE
NC score	0.914614 (rank : 59)	θ value	1.29031e-22 (rank : 99)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	761
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

NTRK2_HUMAN
NC score	0.914030 (rank : 60)	θ value	7.52953e-39 (rank : 7)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1081	Shared Neighborhood Hits	750
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.913891 (rank : 61)	θ value	5.76516e-39 (rank : 6)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1088	Shared Neighborhood Hits	752
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ERBB4_HUMAN
NC score	0.913821 (rank : 62)	θ value	1.5773e-20 (rank : 116)
Query Neighborhood Hits	1243	Target Neighborhood Hits	910	Shared Neighborhood Hits	751
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

PTK6_MOUSE
NC score	0.913107 (rank : 63)	θ value	1.05554e-24 (rank : 81)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1026	Shared Neighborhood Hits	758
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

FER_HUMAN
NC score	0.913098 (rank : 64)	θ value	5.59698e-26 (rank : 70)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1278	Shared Neighborhood Hits	761
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

TYK2_MOUSE
NC score	0.912965 (rank : 65)	θ value	6.62687e-19 (rank : 140)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	766
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

BTK_MOUSE
NC score	0.912692 (rank : 66)	θ value	4.28545e-26 (rank : 69)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1017	Shared Neighborhood Hits	756
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PTK6_HUMAN
NC score	0.912571 (rank : 67)	θ value	1.37858e-24 (rank : 84)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1020	Shared Neighborhood Hits	758
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BTK_HUMAN
NC score	0.912349 (rank : 68)	θ value	2.51237e-26 (rank : 66)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1026	Shared Neighborhood Hits	755
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

LCK_MOUSE
NC score	0.912255 (rank : 69)	θ value	8.36355e-22 (rank : 104)
Query Neighborhood Hits	1243	Target Neighborhood Hits	981	Shared Neighborhood Hits	763
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_HUMAN
NC score	0.911866 (rank : 70)	θ value	5.06226e-27 (rank : 61)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1022	Shared Neighborhood Hits	763
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LCK_HUMAN
NC score	0.911835 (rank : 71)	θ value	8.36355e-22 (rank : 103)
Query Neighborhood Hits	1243	Target Neighborhood Hits	987	Shared Neighborhood Hits	765
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

TYK2_HUMAN
NC score	0.911734 (rank : 72)	θ value	1.74391e-19 (rank : 127)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	761
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

LYN_MOUSE
NC score	0.911573 (rank : 73)	θ value	3.87602e-27 (rank : 59)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1023	Shared Neighborhood Hits	764
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

UFO_HUMAN
NC score	0.911436 (rank : 74)	θ value	3.3877e-31 (rank : 27)
Query Neighborhood Hits	1243	Target Neighborhood Hits	981	Shared Neighborhood Hits	715
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

RYK_HUMAN
NC score	0.911347 (rank : 75)	θ value	3.74554e-30 (rank : 33)
Query Neighborhood Hits	1243	Target Neighborhood Hits	701	Shared Neighborhood Hits	661
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

MERTK_MOUSE
NC score	0.911271 (rank : 76)	θ value	1.33217e-27 (rank : 53)
Query Neighborhood Hits	1243	Target Neighborhood Hits	974	Shared Neighborhood Hits	718
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

BLK_HUMAN
NC score	0.911182 (rank : 77)	θ value	1.29031e-22 (rank : 98)
Query Neighborhood Hits	1243	Target Neighborhood Hits	994	Shared Neighborhood Hits	759
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ERBB3_MOUSE
NC score	0.911162 (rank : 78)	θ value	2.69047e-20 (rank : 120)
Query Neighborhood Hits	1243	Target Neighborhood Hits	898	Shared Neighborhood Hits	737
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

BLK_MOUSE
NC score	0.910642 (rank : 79)	θ value	1.42661e-21 (rank : 105)
Query Neighborhood Hits	1243	Target Neighborhood Hits	992	Shared Neighborhood Hits	761
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

UFO_MOUSE
NC score	0.910139 (rank : 80)	θ value	4.00176e-32 (rank : 22)
Query Neighborhood Hits	1243	Target Neighborhood Hits	988	Shared Neighborhood Hits	717
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

EGFR_MOUSE
NC score	0.909967 (rank : 81)	θ value	2.97466e-19 (rank : 132)
Query Neighborhood Hits	1243	Target Neighborhood Hits	927	Shared Neighborhood Hits	756
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

JAK1_MOUSE
NC score	0.909899 (rank : 82)	θ value	1.74391e-19 (rank : 126)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	756
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ERBB2_MOUSE
NC score	0.909816 (rank : 83)	θ value	1.63225e-17 (rank : 151)
Query Neighborhood Hits	1243	Target Neighborhood Hits	918	Shared Neighborhood Hits	761
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

EGFR_HUMAN
NC score	0.909727 (rank : 84)	θ value	2.27762e-19 (rank : 129)
Query Neighborhood Hits	1243	Target Neighborhood Hits	939	Shared Neighborhood Hits	751
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

JAK1_HUMAN
NC score	0.909679 (rank : 85)	θ value	3.88503e-19 (rank : 137)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	757
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

HCK_MOUSE
NC score	0.909491 (rank : 86)	θ value	3.07116e-24 (rank : 88)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1029	Shared Neighborhood Hits	761
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MERTK_HUMAN
NC score	0.909182 (rank : 87)	θ value	1.4233e-29 (rank : 39)
Query Neighborhood Hits	1243	Target Neighborhood Hits	988	Shared Neighborhood Hits	731
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ERBB2_HUMAN
NC score	0.908826 (rank : 88)	θ value	3.63628e-17 (rank : 154)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1073	Shared Neighborhood Hits	820
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

HCK_HUMAN
NC score	0.908707 (rank : 89)	θ value	8.08199e-25 (rank : 79)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1035	Shared Neighborhood Hits	762
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SRC_MOUSE
NC score	0.908557 (rank : 90)	θ value	3.07116e-24 (rank : 89)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1033	Shared Neighborhood Hits	769
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

EPHA5_MOUSE
NC score	0.908504 (rank : 91)	θ value	2.97466e-19 (rank : 133)
Query Neighborhood Hits	1243	Target Neighborhood Hits	950	Shared Neighborhood Hits	761
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

JAK3_HUMAN
NC score	0.908155 (rank : 92)	θ value	1.80466e-16 (rank : 158)
Query Neighborhood Hits	1243	Target Neighborhood Hits	827	Shared Neighborhood Hits	756
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

ROR1_HUMAN
NC score	0.907943 (rank : 93)	θ value	4.89182e-30 (rank : 35)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1018	Shared Neighborhood Hits	748
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
NC score	0.907923 (rank : 94)	θ value	4.14116e-29 (rank : 43)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1025	Shared Neighborhood Hits	751
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

JAK2_MOUSE
NC score	0.907883 (rank : 95)	θ value	2.7842e-17 (rank : 152)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	758
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

NTRK3_HUMAN
NC score	0.907664 (rank : 96)	θ value	1.16434e-31 (rank : 24)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1115	Shared Neighborhood Hits	744
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

ERBB3_HUMAN
NC score	0.907533 (rank : 97)	θ value	4.15078e-21 (rank : 109)
Query Neighborhood Hits	1243	Target Neighborhood Hits	918	Shared Neighborhood Hits	732
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

JAK2_HUMAN
NC score	0.907079 (rank : 98)	θ value	3.63628e-17 (rank : 155)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	759
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

FGFR2_MOUSE
NC score	0.906985 (rank : 99)	θ value	5.59698e-26 (rank : 72)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1062	Shared Neighborhood Hits	756
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

SRC_HUMAN
NC score	0.905882 (rank : 100)	θ value	1.05554e-24 (rank : 82)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1058	Shared Neighborhood Hits	769
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGFR2_HUMAN
NC score	0.904126 (rank : 101)	θ value	5.59698e-26 (rank : 71)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1062	Shared Neighborhood Hits	756
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

EPHA1_HUMAN
NC score	0.904003 (rank : 102)	θ value	2.87452e-22 (rank : 101)
Query Neighborhood Hits	1243	Target Neighborhood Hits	997	Shared Neighborhood Hits	755
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

YES_HUMAN
NC score	0.903182 (rank : 103)	θ value	8.08199e-25 (rank : 80)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1059	Shared Neighborhood Hits	763
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.903077 (rank : 104)	θ value	1.05554e-24 (rank : 83)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1052	Shared Neighborhood Hits	762
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.902998 (rank : 105)	θ value	2.96777e-27 (rank : 58)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1073	Shared Neighborhood Hits	766
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FGFR3_HUMAN
NC score	0.902787 (rank : 106)	θ value	7.06379e-29 (rank : 44)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1042	Shared Neighborhood Hits	755
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ROR2_HUMAN
NC score	0.902628 (rank : 107)	θ value	2.68423e-28 (rank : 48)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1014	Shared Neighborhood Hits	738
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EPHA1_MOUSE
NC score	0.902352 (rank : 108)	θ value	4.15078e-21 (rank : 107)
Query Neighborhood Hits	1243	Target Neighborhood Hits	958	Shared Neighborhood Hits	747
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_MOUSE
NC score	0.902304 (rank : 109)	θ value	1.16704e-23 (rank : 93)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1020	Shared Neighborhood Hits	766
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FYN_HUMAN
NC score	0.902196 (rank : 110)	θ value	1.02001e-27 (rank : 51)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1078	Shared Neighborhood Hits	765
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

EPHA2_HUMAN
NC score	0.901452 (rank : 111)	θ value	3.07116e-24 (rank : 87)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1021	Shared Neighborhood Hits	767
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

FGFR1_MOUSE
NC score	0.901301 (rank : 112)	θ value	2.68423e-28 (rank : 47)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1068	Shared Neighborhood Hits	760
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.901065 (rank : 113)	θ value	2.68423e-28 (rank : 46)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1069	Shared Neighborhood Hits	760
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

TYRO3_MOUSE
NC score	0.901031 (rank : 114)	θ value	1.12775e-26 (rank : 65)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1007	Shared Neighborhood Hits	727
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

JAK3_MOUSE
NC score	0.899881 (rank : 115)	θ value	1.52774e-15 (rank : 163)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	750
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

TYRO3_HUMAN
NC score	0.899855 (rank : 116)	θ value	8.63488e-27 (rank : 64)
Query Neighborhood Hits	1243	Target Neighborhood Hits	995	Shared Neighborhood Hits	726
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

FGFR3_MOUSE
NC score	0.898576 (rank : 117)	θ value	7.30988e-26 (rank : 74)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1059	Shared Neighborhood Hits	752
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGR_HUMAN
NC score	0.898558 (rank : 118)	θ value	1.24688e-25 (rank : 76)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1067	Shared Neighborhood Hits	763
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGFR4_HUMAN
NC score	0.898024 (rank : 119)	θ value	7.80994e-28 (rank : 50)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1037	Shared Neighborhood Hits	752
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGR_MOUSE
NC score	0.897480 (rank : 120)	θ value	5.59698e-26 (rank : 73)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1069	Shared Neighborhood Hits	763
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLT3_HUMAN
NC score	0.897047 (rank : 121)	θ value	1.29331e-14 (rank : 169)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	734
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

ROR2_MOUSE
NC score	0.896958 (rank : 122)	θ value	8.63488e-27 (rank : 63)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1000	Shared Neighborhood Hits	725
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

EPHB1_HUMAN
NC score	0.895088 (rank : 123)	θ value	8.93572e-24 (rank : 92)
Query Neighborhood Hits	1243	Target Neighborhood Hits	988	Shared Neighborhood Hits	755
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

FGFR4_MOUSE
NC score	0.894357 (rank : 124)	θ value	5.06226e-27 (rank : 60)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1026	Shared Neighborhood Hits	738
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA3_HUMAN
NC score	0.894171 (rank : 125)	θ value	2.69047e-20 (rank : 118)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1005	Shared Neighborhood Hits	761
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

FLT3_MOUSE
NC score	0.893658 (rank : 126)	θ value	7.58209e-15 (rank : 168)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	734
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

EPHB4_MOUSE
NC score	0.893344 (rank : 127)	θ value	5.99374e-20 (rank : 122)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1013	Shared Neighborhood Hits	752
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB4_HUMAN
NC score	0.893162 (rank : 128)	θ value	2.69047e-20 (rank : 119)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1056	Shared Neighborhood Hits	753
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHA3_MOUSE
NC score	0.892274 (rank : 129)	θ value	4.15078e-21 (rank : 108)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	765
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHB2_MOUSE
NC score	0.892038 (rank : 130)	θ value	2.20094e-22 (rank : 100)
Query Neighborhood Hits	1243	Target Neighborhood Hits	982	Shared Neighborhood Hits	756
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.891852 (rank : 131)	θ value	2.87452e-22 (rank : 102)
Query Neighborhood Hits	1243	Target Neighborhood Hits	983	Shared Neighborhood Hits	756
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA5_HUMAN
NC score	0.891398 (rank : 132)	θ value	2.27762e-19 (rank : 130)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	763
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

TIE2_HUMAN
NC score	0.891061 (rank : 133)	θ value	1.5242e-23 (rank : 96)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1192	Shared Neighborhood Hits	761
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EPHA8_HUMAN
NC score	0.890998 (rank : 134)	θ value	3.28887e-18 (rank : 148)
Query Neighborhood Hits	1243	Target Neighborhood Hits	956	Shared Neighborhood Hits	756
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

TIE2_MOUSE
NC score	0.890841 (rank : 135)	θ value	2.35151e-24 (rank : 85)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1204	Shared Neighborhood Hits	763
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

EPHA4_HUMAN
NC score	0.890836 (rank : 136)	θ value	1.92812e-18 (rank : 145)
Query Neighborhood Hits	1243	Target Neighborhood Hits	975	Shared Neighborhood Hits	760
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

M3K12_MOUSE
NC score	0.890734 (rank : 137)	θ value	2.97466e-19 (rank : 136)
Query Neighborhood Hits	1243	Target Neighborhood Hits	957	Shared Neighborhood Hits	787
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

EPHA4_MOUSE
NC score	0.890600 (rank : 138)	θ value	1.92812e-18 (rank : 146)
Query Neighborhood Hits	1243	Target Neighborhood Hits	982	Shared Neighborhood Hits	760
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

M3K12_HUMAN
NC score	0.890571 (rank : 139)	θ value	2.97466e-19 (rank : 135)
Query Neighborhood Hits	1243	Target Neighborhood Hits	940	Shared Neighborhood Hits	784
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

KIT_HUMAN
NC score	0.890293 (rank : 140)	θ value	1.80466e-16 (rank : 159)
Query Neighborhood Hits	1243	Target Neighborhood Hits	953	Shared Neighborhood Hits	744
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

EPHA7_MOUSE
NC score	0.889408 (rank : 141)	θ value	1.02238e-19 (rank : 124)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1025	Shared Neighborhood Hits	761
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

MLTK_MOUSE
NC score	0.888893 (rank : 142)	θ value	3.89403e-11 (rank : 221)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	754
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

CSF1R_HUMAN
NC score	0.888579 (rank : 143)	θ value	1.13037e-18 (rank : 142)
Query Neighborhood Hits	1243	Target Neighborhood Hits	943	Shared Neighborhood Hits	737
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHA7_HUMAN
NC score	0.888537 (rank : 144)	θ value	1.02238e-19 (rank : 123)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1053	Shared Neighborhood Hits	762
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

MLTK_HUMAN
NC score	0.888537 (rank : 145)	θ value	6.64225e-11 (rank : 228)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	761
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

EPHB3_HUMAN
NC score	0.888400 (rank : 146)	θ value	9.24701e-21 (rank : 111)
Query Neighborhood Hits	1243	Target Neighborhood Hits	996	Shared Neighborhood Hits	759
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
NC score	0.888339 (rank : 147)	θ value	1.2077e-20 (rank : 114)
Query Neighborhood Hits	1243	Target Neighborhood Hits	996	Shared Neighborhood Hits	762
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHA8_MOUSE
NC score	0.888308 (rank : 148)	θ value	1.47631e-18 (rank : 143)
Query Neighborhood Hits	1243	Target Neighborhood Hits	969	Shared Neighborhood Hits	754
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

M3K13_HUMAN
NC score	0.887046 (rank : 149)	θ value	5.60996e-18 (rank : 149)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	766
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

BRAF1_HUMAN
NC score	0.886607 (rank : 150)	θ value	5.8054e-15 (rank : 167)
Query Neighborhood Hits	1243	Target Neighborhood Hits	883	Shared Neighborhood Hits	758
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

PGFRB_HUMAN
NC score	0.886367 (rank : 151)	θ value	2.27762e-19 (rank : 131)
Query Neighborhood Hits	1243	Target Neighborhood Hits	962	Shared Neighborhood Hits	742
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

KIT_MOUSE
NC score	0.885436 (rank : 152)	θ value	6.85773e-16 (rank : 161)
Query Neighborhood Hits	1243	Target Neighborhood Hits	949	Shared Neighborhood Hits	742
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

ARAF_MOUSE
NC score	0.884968 (rank : 153)	θ value	4.91457e-14 (rank : 172)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	758
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

M3K11_HUMAN
NC score	0.884080 (rank : 154)	θ value	1.24977e-17 (rank : 150)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1136	Shared Neighborhood Hits	806
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PGFRA_MOUSE
NC score	0.883502 (rank : 155)	θ value	6.20254e-17 (rank : 157)
Query Neighborhood Hits	1243	Target Neighborhood Hits	975	Shared Neighborhood Hits	740
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_HUMAN
NC score	0.883302 (rank : 156)	θ value	6.20254e-17 (rank : 156)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	741
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ARAF_HUMAN
NC score	0.883123 (rank : 157)	θ value	1.68911e-14 (rank : 170)
Query Neighborhood Hits	1243	Target Neighborhood Hits	924	Shared Neighborhood Hits	768
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PGFRB_MOUSE
NC score	0.883037 (rank : 158)	θ value	8.65492e-19 (rank : 141)
Query Neighborhood Hits	1243	Target Neighborhood Hits	960	Shared Neighborhood Hits	739
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

TIE1_HUMAN
NC score	0.882295 (rank : 159)	θ value	4.01107e-24 (rank : 90)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1241	Shared Neighborhood Hits	761
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
NC score	0.881831 (rank : 160)	θ value	4.01107e-24 (rank : 91)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1266	Shared Neighborhood Hits	764
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

RAF1_MOUSE
NC score	0.881821 (rank : 161)	θ value	7.09661e-13 (rank : 186)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	758
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

M3KL4_HUMAN
NC score	0.881427 (rank : 162)	θ value	1.16975e-15 (rank : 162)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1087	Shared Neighborhood Hits	765
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RAF1_HUMAN
NC score	0.880745 (rank : 163)	θ value	9.26847e-13 (rank : 189)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	756
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CSF1R_MOUSE
NC score	0.880432 (rank : 164)	θ value	2.27762e-19 (rank : 128)
Query Neighborhood Hits	1243	Target Neighborhood Hits	983	Shared Neighborhood Hits	737
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

M3K10_HUMAN
NC score	0.879425 (rank : 165)	θ value	5.25075e-16 (rank : 160)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1071	Shared Neighborhood Hits	763
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

EPHA6_MOUSE
NC score	0.879191 (rank : 166)	θ value	1.42992e-13 (rank : 175)
Query Neighborhood Hits	1243	Target Neighborhood Hits	946	Shared Neighborhood Hits	750
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_HUMAN
NC score	0.878702 (rank : 167)	θ value	4.91457e-14 (rank : 173)
Query Neighborhood Hits	1243	Target Neighborhood Hits	959	Shared Neighborhood Hits	754
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

M3K9_HUMAN
NC score	0.878273 (rank : 168)	θ value	4.16044e-13 (rank : 180)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1123	Shared Neighborhood Hits	789
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

RIPK1_HUMAN
NC score	0.878030 (rank : 169)	θ value	6.41864e-14 (rank : 174)
Query Neighborhood Hits	1243	Target Neighborhood Hits	891	Shared Neighborhood Hits	765
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
NC score	0.876883 (rank : 170)	θ value	6.00763e-12 (rank : 197)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	762
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

VGFR3_HUMAN
NC score	0.874423 (rank : 171)	θ value	1.92812e-18 (rank : 147)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1037	Shared Neighborhood Hits	744
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
NC score	0.872555 (rank : 172)	θ value	5.07402e-19 (rank : 138)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1056	Shared Neighborhood Hits	741
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

M3K7_MOUSE
NC score	0.868566 (rank : 173)	θ value	4.0297e-08 (rank : 341)
Query Neighborhood Hits	1243	Target Neighborhood Hits	892	Shared Neighborhood Hits	758
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.868458 (rank : 174)	θ value	4.0297e-08 (rank : 340)
Query Neighborhood Hits	1243	Target Neighborhood Hits	892	Shared Neighborhood Hits	758
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

TESK2_MOUSE
NC score	0.866819 (rank : 175)	θ value	3.89403e-11 (rank : 223)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	751
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_HUMAN
NC score	0.866634 (rank : 176)	θ value	1.33837e-11 (rank : 206)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	758
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

IRAK4_HUMAN
NC score	0.866564 (rank : 177)	θ value	9.26847e-13 (rank : 187)
Query Neighborhood Hits	1243	Target Neighborhood Hits	816	Shared Neighborhood Hits	748
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

EPHAA_HUMAN
NC score	0.866267 (rank : 178)	θ value	2.60593e-15 (rank : 165)
Query Neighborhood Hits	1243	Target Neighborhood Hits	960	Shared Neighborhood Hits	709
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MUSK_HUMAN
NC score	0.863401 (rank : 179)	θ value	2.26708e-35 (rank : 18)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1074	Shared Neighborhood Hits	739
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

IRAK4_MOUSE
NC score	0.862492 (rank : 180)	θ value	3.18553e-13 (rank : 179)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	750
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

MUSK_MOUSE
NC score	0.860968 (rank : 181)	θ value	7.29293e-34 (rank : 20)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1057	Shared Neighborhood Hits	737
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MOS_HUMAN
NC score	0.860485 (rank : 182)	θ value	0.000158464 (rank : 571)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	753
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

KSR1_MOUSE
NC score	0.860199 (rank : 183)	θ value	3.64472e-09 (rank : 294)
Query Neighborhood Hits	1243	Target Neighborhood Hits	870	Shared Neighborhood Hits	752
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MOS_MOUSE
NC score	0.857921 (rank : 184)	θ value	2.21117e-06 (rank : 450)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

KSR1_HUMAN
NC score	0.857448 (rank : 185)	θ value	1.38499e-08 (rank : 319)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	746
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

TESK1_MOUSE
NC score	0.857197 (rank : 186)	θ value	6.87365e-08 (rank : 355)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	756
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

VGFR2_MOUSE
NC score	0.856639 (rank : 187)	θ value	1.47631e-18 (rank : 144)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1089	Shared Neighborhood Hits	745
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

TESK1_HUMAN
NC score	0.856255 (rank : 188)	θ value	1.17247e-07 (rank : 369)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	761
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

KSR2_HUMAN
NC score	0.855071 (rank : 189)	θ value	8.67504e-11 (rank : 231)
Query Neighborhood Hits	1243	Target Neighborhood Hits	920	Shared Neighborhood Hits	782
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

VGFR1_MOUSE
NC score	0.853928 (rank : 190)	θ value	9.24701e-21 (rank : 113)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1118	Shared Neighborhood Hits	752
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
NC score	0.853646 (rank : 191)	θ value	3.51386e-20 (rank : 121)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1103	Shared Neighborhood Hits	744
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

RIPK3_HUMAN
NC score	0.853167 (rank : 192)	θ value	1.99992e-07 (rank : 384)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	750
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

VGFR1_HUMAN
NC score	0.850392 (rank : 193)	θ value	2.7842e-17 (rank : 153)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1109	Shared Neighborhood Hits	750
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

RIPK2_MOUSE
NC score	0.849413 (rank : 194)	θ value	1.69304e-06 (rank : 447)
Query Neighborhood Hits	1243	Target Neighborhood Hits	776	Shared Neighborhood Hits	707
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

MLKL_MOUSE
NC score	0.846567 (rank : 195)	θ value	0.00228821 (rank : 646)
Query Neighborhood Hits	1243	Target Neighborhood Hits	707	Shared Neighborhood Hits	660
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

LIMK2_HUMAN
NC score	0.844246 (rank : 196)	θ value	1.33837e-11 (rank : 200)
Query Neighborhood Hits	1243	Target Neighborhood Hits	986	Shared Neighborhood Hits	760
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RIPK2_HUMAN
NC score	0.844022 (rank : 197)	θ value	1.43324e-05 (rank : 511)
Query Neighborhood Hits	1243	Target Neighborhood Hits	774	Shared Neighborhood Hits	709
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

EPHB6_MOUSE
NC score	0.843509 (rank : 198)	θ value	7.09661e-13 (rank : 183)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	678
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

PTK7_HUMAN
NC score	0.842273 (rank : 199)	θ value	1.12253e-42 (rank : 3)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1103	Shared Neighborhood Hits	727
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

LIMK2_MOUSE
NC score	0.841313 (rank : 200)	θ value	6.64225e-11 (rank : 227)
Query Neighborhood Hits	1243	Target Neighborhood Hits	998	Shared Neighborhood Hits	759
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

EPHB6_HUMAN
NC score	0.836719 (rank : 201)	θ value	2.88119e-14 (rank : 171)
Query Neighborhood Hits	1243	Target Neighborhood Hits	912	Shared Neighborhood Hits	659
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

LIMK1_HUMAN
NC score	0.835484 (rank : 202)	θ value	4.30538e-10 (rank : 255)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1005	Shared Neighborhood Hits	756
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.835416 (rank : 203)	θ value	9.59137e-10 (rank : 272)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1008	Shared Neighborhood Hits	758
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RIPK5_HUMAN
NC score	0.831021 (rank : 204)	θ value	0.000786445 (rank : 619)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	758
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
NC score	0.830261 (rank : 205)	θ value	0.000786445 (rank : 620)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	758
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RIPK3_MOUSE
NC score	0.823648 (rank : 206)	θ value	5.44631e-05 (rank : 540)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	766
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

IRAK1_MOUSE
NC score	0.823281 (rank : 207)	θ value	8.11959e-09 (rank : 312)
Query Neighborhood Hits	1243	Target Neighborhood Hits	784	Shared Neighborhood Hits	706
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK1_HUMAN
NC score	0.822322 (rank : 208)	θ value	9.59137e-10 (rank : 270)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	725
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

YSK4_HUMAN
NC score	0.813854 (rank : 209)	θ value	2.43908e-13 (rank : 178)
Query Neighborhood Hits	1243	Target Neighborhood Hits	921	Shared Neighborhood Hits	761
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

MLKL_HUMAN
NC score	0.812724 (rank : 210)	θ value	0.00035302 (rank : 594)
Query Neighborhood Hits	1243	Target Neighborhood Hits	600	Shared Neighborhood Hits	548
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

NEK11_MOUSE
NC score	0.809273 (rank : 211)	θ value	7.1131e-05 (rank : 549)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	758
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK24_MOUSE
NC score	0.807739 (rank : 212)	θ value	7.59969e-07 (rank : 426)
Query Neighborhood Hits	1243	Target Neighborhood Hits	856	Shared Neighborhood Hits	760
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK24_HUMAN
NC score	0.807457 (rank : 213)	θ value	5.81887e-07 (rank : 413)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

NEK11_HUMAN
NC score	0.807317 (rank : 214)	θ value	1.69304e-06 (rank : 446)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1043	Shared Neighborhood Hits	770
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK7_HUMAN
NC score	0.804163 (rank : 215)	θ value	1.33837e-11 (rank : 203)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	760
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
NC score	0.803944 (rank : 216)	θ value	1.02475e-11 (rank : 198)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	760
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MST4_HUMAN
NC score	0.803526 (rank : 217)	θ value	4.45536e-07 (rank : 401)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	760
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
NC score	0.803250 (rank : 218)	θ value	4.45536e-07 (rank : 402)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	760
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK25_MOUSE
NC score	0.800917 (rank : 219)	θ value	1.29631e-06 (rank : 442)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	760
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_HUMAN
NC score	0.800518 (rank : 220)	θ value	9.92553e-07 (rank : 434)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	760
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NEK6_MOUSE
NC score	0.798768 (rank : 221)	θ value	9.26847e-13 (rank : 188)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	760
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK6_HUMAN
NC score	0.798496 (rank : 222)	θ value	7.09661e-13 (rank : 185)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	760
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK4_MOUSE
NC score	0.797449 (rank : 223)	θ value	2.28291e-11 (rank : 210)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	762
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

OXSR1_MOUSE
NC score	0.797179 (rank : 224)	θ value	1.33837e-11 (rank : 204)
Query Neighborhood Hits	1243	Target Neighborhood Hits	865	Shared Neighborhood Hits	760
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_HUMAN
NC score	0.797134 (rank : 225)	θ value	5.62301e-10 (rank : 262)
Query Neighborhood Hits	1243	Target Neighborhood Hits	882	Shared Neighborhood Hits	765
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
NC score	0.797131 (rank : 226)	θ value	5.62301e-10 (rank : 263)
Query Neighborhood Hits	1243	Target Neighborhood Hits	915	Shared Neighborhood Hits	772
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

OXSR1_HUMAN
NC score	0.796895 (rank : 227)	θ value	1.74796e-11 (rank : 207)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	766
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

NEK4_HUMAN
NC score	0.796137 (rank : 228)	θ value	2.98157e-11 (rank : 216)
Query Neighborhood Hits	1243	Target Neighborhood Hits	883	Shared Neighborhood Hits	759
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

ACVL1_MOUSE
NC score	0.791508 (rank : 229)	θ value	7.34386e-10 (rank : 264)
Query Neighborhood Hits	1243	Target Neighborhood Hits	739	Shared Neighborhood Hits	708
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

STK4_MOUSE
NC score	0.791177 (rank : 230)	θ value	3.29651e-10 (rank : 252)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	761
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	0.790844 (rank : 231)	θ value	4.30538e-10 (rank : 258)
Query Neighborhood Hits	1243	Target Neighborhood Hits	870	Shared Neighborhood Hits	760
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK3_MOUSE
NC score	0.789236 (rank : 232)	θ value	2.52405e-10 (rank : 249)
Query Neighborhood Hits	1243	Target Neighborhood Hits	869	Shared Neighborhood Hits	757
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK3_HUMAN
NC score	0.788380 (rank : 233)	θ value	1.47974e-10 (rank : 242)
Query Neighborhood Hits	1243	Target Neighborhood Hits	861	Shared Neighborhood Hits	758
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

NEK3_HUMAN
NC score	0.788167 (rank : 234)	θ value	1.47974e-10 (rank : 240)
Query Neighborhood Hits	1243	Target Neighborhood Hits	865	Shared Neighborhood Hits	758
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

IKKA_HUMAN
NC score	0.787090 (rank : 235)	θ value	5.26297e-08 (rank : 348)
Query Neighborhood Hits	1243	Target Neighborhood Hits	863	Shared Neighborhood Hits	752
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

E2AK2_MOUSE
NC score	0.786843 (rank : 236)	θ value	1.53129e-07 (rank : 372)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	756
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

MP2K5_MOUSE
NC score	0.785650 (rank : 237)	θ value	8.40245e-06 (rank : 490)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

E2AK2_HUMAN
NC score	0.785614 (rank : 238)	θ value	0.00298849 (rank : 652)
Query Neighborhood Hits	1243	Target Neighborhood Hits	856	Shared Neighborhood Hits	749
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

IKKA_MOUSE
NC score	0.784654 (rank : 239)	θ value	2.61198e-07 (rank : 387)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	752
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NEK3_MOUSE
NC score	0.782625 (rank : 240)	θ value	9.59137e-10 (rank : 273)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	758
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK1_HUMAN
NC score	0.782618 (rank : 241)	θ value	3.52202e-12 (rank : 194)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1129	Shared Neighborhood Hits	772
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
NC score	0.782372 (rank : 242)	θ value	1.33837e-11 (rank : 202)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1311	Shared Neighborhood Hits	790
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ULK1_MOUSE
NC score	0.780825 (rank : 243)	θ value	2.98157e-11 (rank : 218)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1214	Shared Neighborhood Hits	906
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

BMR1B_MOUSE
NC score	0.780427 (rank : 244)	θ value	3.41135e-07 (rank : 391)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	706
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1A_HUMAN
NC score	0.780040 (rank : 245)	θ value	2.13673e-09 (rank : 283)
Query Neighborhood Hits	1243	Target Neighborhood Hits	759	Shared Neighborhood Hits	716
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

ULK1_HUMAN
NC score	0.779889 (rank : 246)	θ value	6.64225e-11 (rank : 229)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1121	Shared Neighborhood Hits	868
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

M3K15_HUMAN
NC score	0.779170 (rank : 247)	θ value	8.67504e-11 (rank : 232)
Query Neighborhood Hits	1243	Target Neighborhood Hits	914	Shared Neighborhood Hits	762
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

BMR1A_MOUSE
NC score	0.779100 (rank : 248)	θ value	7.34386e-10 (rank : 265)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	715
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

NEK2_HUMAN
NC score	0.778994 (rank : 249)	θ value	3.89403e-11 (rank : 222)
Query Neighborhood Hits	1243	Target Neighborhood Hits	908	Shared Neighborhood Hits	754
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

TAOK2_HUMAN
NC score	0.778669 (rank : 250)	θ value	1.74796e-11 (rank : 208)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1172	Shared Neighborhood Hits	777
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

BMR1B_HUMAN
NC score	0.778133 (rank : 251)	θ value	5.81887e-07 (rank : 407)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	705
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

IKKB_HUMAN
NC score	0.777770 (rank : 252)	θ value	1.99992e-07 (rank : 376)
Query Neighborhood Hits	1243	Target Neighborhood Hits	980	Shared Neighborhood Hits	760
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

ULK2_MOUSE
NC score	0.776880 (rank : 253)	θ value	3.29651e-10 (rank : 253)
Query Neighborhood Hits	1243	Target Neighborhood Hits	943	Shared Neighborhood Hits	785
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ACVL1_HUMAN
NC score	0.776062 (rank : 254)	θ value	4.0297e-08 (rank : 335)
Query Neighborhood Hits	1243	Target Neighborhood Hits	716	Shared Neighborhood Hits	682
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

MP2K5_HUMAN
NC score	0.776055 (rank : 255)	θ value	0.0148317 (rank : 712)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	749
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

ULK2_HUMAN
NC score	0.775772 (rank : 256)	θ value	1.9326e-10 (rank : 246)
Query Neighborhood Hits	1243	Target Neighborhood Hits	979	Shared Neighborhood Hits	794
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

M3K3_HUMAN
NC score	0.774783 (rank : 257)	θ value	6.00763e-12 (rank : 195)
Query Neighborhood Hits	1243	Target Neighborhood Hits	885	Shared Neighborhood Hits	761
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

IKKB_MOUSE
NC score	0.774197 (rank : 258)	θ value	1.17247e-07 (rank : 365)
Query Neighborhood Hits	1243	Target Neighborhood Hits	984	Shared Neighborhood Hits	758
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

TNI3K_MOUSE
NC score	0.773370 (rank : 259)	θ value	4.92598e-06 (rank : 472)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1079	Shared Neighborhood Hits	740
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

M3K3_MOUSE
NC score	0.772872 (rank : 260)	θ value	2.98157e-11 (rank : 215)
Query Neighborhood Hits	1243	Target Neighborhood Hits	876	Shared Neighborhood Hits	759
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K5_MOUSE
NC score	0.772431 (rank : 261)	θ value	3.89403e-11 (rank : 220)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	760
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.772070 (rank : 262)	θ value	3.89403e-11 (rank : 219)
Query Neighborhood Hits	1243	Target Neighborhood Hits	868	Shared Neighborhood Hits	760
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K1_MOUSE
NC score	0.771982 (rank : 263)	θ value	8.40245e-06 (rank : 489)
Query Neighborhood Hits	1243	Target Neighborhood Hits	952	Shared Neighborhood Hits	777
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K6_HUMAN
NC score	0.771763 (rank : 264)	θ value	1.33837e-11 (rank : 201)
Query Neighborhood Hits	1243	Target Neighborhood Hits	889	Shared Neighborhood Hits	766
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

STK36_MOUSE
NC score	0.770585 (rank : 265)	θ value	2.13673e-09 (rank : 286)
Query Neighborhood Hits	1243	Target Neighborhood Hits	877	Shared Neighborhood Hits	762
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ACVR1_MOUSE
NC score	0.770525 (rank : 266)	θ value	4.0297e-08 (rank : 337)
Query Neighborhood Hits	1243	Target Neighborhood Hits	768	Shared Neighborhood Hits	721
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ULK3_HUMAN
NC score	0.770365 (rank : 267)	θ value	6.43352e-06 (rank : 486)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	750
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

NUAK2_HUMAN
NC score	0.770134 (rank : 268)	θ value	4.44505e-15 (rank : 166)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	764
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NEK2_MOUSE
NC score	0.770087 (rank : 269)	θ value	6.21693e-09 (rank : 310)
Query Neighborhood Hits	1243	Target Neighborhood Hits	876	Shared Neighborhood Hits	753
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

TNI3K_HUMAN
NC score	0.769085 (rank : 270)	θ value	8.40245e-06 (rank : 492)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1084	Shared Neighborhood Hits	742
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TOPK_MOUSE
NC score	0.768828 (rank : 271)	θ value	0.0148317 (rank : 715)
Query Neighborhood Hits	1243	Target Neighborhood Hits	618	Shared Neighborhood Hits	569
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

NEK9_HUMAN
NC score	0.768801 (rank : 272)	θ value	2.28291e-11 (rank : 211)
Query Neighborhood Hits	1243	Target Neighborhood Hits	900	Shared Neighborhood Hits	761
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

PAK6_HUMAN
NC score	0.768460 (rank : 273)	θ value	1.99992e-07 (rank : 382)
Query Neighborhood Hits	1243	Target Neighborhood Hits	915	Shared Neighborhood Hits	780
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

NEK8_HUMAN
NC score	0.767341 (rank : 274)	θ value	1.63604e-09 (rank : 282)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	756
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

PAK7_HUMAN
NC score	0.767128 (rank : 275)	θ value	4.0297e-08 (rank : 344)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	765
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

ACVR1_HUMAN
NC score	0.767012 (rank : 276)	θ value	4.0297e-08 (rank : 336)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	717
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

M3K2_HUMAN
NC score	0.766868 (rank : 277)	θ value	6.21693e-09 (rank : 307)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	757
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

NEK9_MOUSE
NC score	0.766489 (rank : 278)	θ value	3.29651e-10 (rank : 251)
Query Neighborhood Hits	1243	Target Neighborhood Hits	890	Shared Neighborhood Hits	758
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK8_MOUSE
NC score	0.766253 (rank : 279)	θ value	2.79066e-09 (rank : 291)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	755
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

STK36_HUMAN
NC score	0.766231 (rank : 280)	θ value	7.34386e-10 (rank : 267)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	765
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

TAOK2_MOUSE
NC score	0.766151 (rank : 281)	θ value	1.33837e-11 (rank : 205)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1373	Shared Neighborhood Hits	786
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

PAK7_MOUSE
NC score	0.765811 (rank : 282)	θ value	1.53129e-07 (rank : 373)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	765
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

ULK3_MOUSE
NC score	0.765517 (rank : 283)	θ value	3.08544e-08 (rank : 334)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	758
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

NUAK1_HUMAN
NC score	0.764326 (rank : 284)	θ value	1.9326e-10 (rank : 245)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	765
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

M4K1_MOUSE
NC score	0.763842 (rank : 285)	θ value	6.43352e-06 (rank : 478)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	765
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

STK16_HUMAN
NC score	0.763726 (rank : 286)	θ value	0.00665767 (rank : 687)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	748
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

M4K1_HUMAN
NC score	0.763677 (rank : 287)	θ value	1.43324e-05 (rank : 507)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	766
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

NUAK2_MOUSE
NC score	0.762946 (rank : 288)	θ value	1.2105e-12 (rank : 190)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	763
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

NUAK1_MOUSE
NC score	0.762582 (rank : 289)	θ value	2.52405e-10 (rank : 248)
Query Neighborhood Hits	1243	Target Neighborhood Hits	881	Shared Neighborhood Hits	766
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

STK33_HUMAN
NC score	0.762572 (rank : 290)	θ value	2.79066e-09 (rank : 293)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	758
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

M3K4_HUMAN
NC score	0.761835 (rank : 291)	θ value	4.0297e-08 (rank : 339)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	770
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

AAPK1_HUMAN
NC score	0.761473 (rank : 292)	θ value	1.25267e-09 (rank : 274)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	752
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

PAK4_MOUSE
NC score	0.761465 (rank : 293)	θ value	3.08544e-08 (rank : 332)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1098	Shared Neighborhood Hits	844
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK2_MOUSE
NC score	0.761387 (rank : 294)	θ value	9.92553e-07 (rank : 432)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	764
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK2_HUMAN
NC score	0.760900 (rank : 295)	θ value	9.92553e-07 (rank : 431)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	766
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

STK35_HUMAN
NC score	0.760884 (rank : 296)	θ value	4.30538e-10 (rank : 257)
Query Neighborhood Hits	1243	Target Neighborhood Hits	825	Shared Neighborhood Hits	748
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

AAPK1_MOUSE
NC score	0.760880 (rank : 297)	θ value	1.25267e-09 (rank : 275)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	752
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

TGFR1_MOUSE
NC score	0.760804 (rank : 298)	θ value	4.76016e-09 (rank : 300)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	712
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR1_HUMAN
NC score	0.760566 (rank : 299)	θ value	4.76016e-09 (rank : 299)
Query Neighborhood Hits	1243	Target Neighborhood Hits	755	Shared Neighborhood Hits	712
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

PLK4_MOUSE
NC score	0.760425 (rank : 300)	θ value	2.0648e-12 (rank : 192)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	758
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PAK1_MOUSE
NC score	0.760171 (rank : 301)	θ value	4.45536e-07 (rank : 404)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	770
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK4_HUMAN
NC score	0.759901 (rank : 302)	θ value	4.0297e-08 (rank : 343)
Query Neighborhood Hits	1243	Target Neighborhood Hits	924	Shared Neighborhood Hits	782
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

M3K4_MOUSE
NC score	0.759635 (rank : 303)	θ value	1.99992e-07 (rank : 379)
Query Neighborhood Hits	1243	Target Neighborhood Hits	924	Shared Neighborhood Hits	770
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

PAK1_HUMAN
NC score	0.759505 (rank : 304)	θ value	2.21117e-06 (rank : 451)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	770
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

STK16_MOUSE
NC score	0.759110 (rank : 305)	θ value	0.000786445 (rank : 623)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	745
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

TOPK_HUMAN
NC score	0.759050 (rank : 306)	θ value	0.0113563 (rank : 706)
Query Neighborhood Hits	1243	Target Neighborhood Hits	605	Shared Neighborhood Hits	553
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

PLK2_MOUSE
NC score	0.758593 (rank : 307)	θ value	4.76016e-09 (rank : 298)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MP2K2_HUMAN
NC score	0.758485 (rank : 308)	θ value	θ > 10 (rank : 1421)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	748
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PLK4_HUMAN
NC score	0.758435 (rank : 309)	θ value	2.0648e-12 (rank : 191)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	757
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

M3K2_MOUSE
NC score	0.758416 (rank : 310)	θ value	6.21693e-09 (rank : 308)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	754
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MARK3_MOUSE
NC score	0.758165 (rank : 311)	θ value	7.34386e-10 (rank : 266)
Query Neighborhood Hits	1243	Target Neighborhood Hits	919	Shared Neighborhood Hits	773
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PLK2_HUMAN
NC score	0.758080 (rank : 312)	θ value	3.08544e-08 (rank : 333)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	757
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

AURKC_MOUSE
NC score	0.757881 (rank : 313)	θ value	1.06045e-08 (rank : 315)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	759
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

MARK4_HUMAN
NC score	0.757878 (rank : 314)	θ value	8.67504e-11 (rank : 233)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	770
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.757753 (rank : 315)	θ value	8.67504e-11 (rank : 234)
Query Neighborhood Hits	1243	Target Neighborhood Hits	898	Shared Neighborhood Hits	769
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

GUC2F_HUMAN
NC score	0.757697 (rank : 316)	θ value	6.21693e-09 (rank : 302)
Query Neighborhood Hits	1243	Target Neighborhood Hits	740	Shared Neighborhood Hits	652
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

M4K3_HUMAN
NC score	0.757679 (rank : 317)	θ value	5.26297e-08 (rank : 350)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	759
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MP2K4_MOUSE
NC score	0.757617 (rank : 318)	θ value	1.09739e-05 (rank : 499)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K4_HUMAN
NC score	0.757606 (rank : 319)	θ value	1.09739e-05 (rank : 498)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	751
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

STK6_HUMAN
NC score	0.757500 (rank : 320)	θ value	2.13673e-09 (rank : 287)
Query Neighborhood Hits	1243	Target Neighborhood Hits	916	Shared Neighborhood Hits	770
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

TSSK4_MOUSE
NC score	0.757462 (rank : 321)	θ value	1.69304e-06 (rank : 448)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	752
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

MARK2_HUMAN
NC score	0.757409 (rank : 322)	θ value	1.133e-10 (rank : 237)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1056	Shared Neighborhood Hits	808
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MINK1_HUMAN
NC score	0.757396 (rank : 323)	θ value	1.17247e-07 (rank : 367)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1477	Shared Neighborhood Hits	808
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
NC score	0.757024 (rank : 324)	θ value	1.17247e-07 (rank : 368)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1451	Shared Neighborhood Hits	799
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MARK3_HUMAN
NC score	0.756791 (rank : 325)	θ value	1.80886e-08 (rank : 324)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	769
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

AURKC_HUMAN
NC score	0.756538 (rank : 326)	θ value	3.77169e-06 (rank : 461)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

MP2K2_MOUSE
NC score	0.756470 (rank : 327)	θ value	θ > 10 (rank : 1422)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	747
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PAK3_MOUSE
NC score	0.756406 (rank : 328)	θ value	1.09739e-05 (rank : 502)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	768
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

MARK1_HUMAN
NC score	0.756250 (rank : 329)	θ value	3.08544e-08 (rank : 331)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	764
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

PAK3_HUMAN
NC score	0.756226 (rank : 330)	θ value	1.09739e-05 (rank : 501)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	772
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

MARK1_MOUSE
NC score	0.756179 (rank : 331)	θ value	6.21693e-09 (rank : 309)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	768
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MP2K7_HUMAN
NC score	0.755550 (rank : 332)	θ value	0.0148317 (rank : 713)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	754
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

NRK_MOUSE
NC score	0.754919 (rank : 333)	θ value	2.36244e-08 (rank : 328)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	757
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NRK_HUMAN
NC score	0.754753 (rank : 334)	θ value	4.45536e-07 (rank : 403)
Query Neighborhood Hits	1243	Target Neighborhood Hits	931	Shared Neighborhood Hits	756
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

AAPK2_HUMAN
NC score	0.754551 (rank : 335)	θ value	1.9326e-10 (rank : 243)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	752
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

PLK1_HUMAN
NC score	0.754306 (rank : 336)	θ value	1.25267e-09 (rank : 280)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

MARK2_MOUSE
NC score	0.754043 (rank : 337)	θ value	1.9326e-10 (rank : 244)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1018	Shared Neighborhood Hits	795
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MP2K1_MOUSE
NC score	0.754001 (rank : 338)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

SN1L2_HUMAN
NC score	0.753947 (rank : 339)	θ value	6.43352e-06 (rank : 483)
Query Neighborhood Hits	1243	Target Neighborhood Hits	964	Shared Neighborhood Hits	787
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MP2K1_HUMAN
NC score	0.753818 (rank : 340)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

BMPR2_HUMAN
NC score	0.753783 (rank : 341)	θ value	2.52405e-10 (rank : 247)
Query Neighborhood Hits	1243	Target Neighborhood Hits	736	Shared Neighborhood Hits	679
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

STK6_MOUSE
NC score	0.753679 (rank : 342)	θ value	2.98157e-11 (rank : 217)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	769
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

CHK1_HUMAN
NC score	0.753095 (rank : 343)	θ value	6.21693e-09 (rank : 301)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	754
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

NIM1_HUMAN
NC score	0.753082 (rank : 344)	θ value	1.02475e-11 (rank : 199)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	757
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

M4K4_MOUSE
NC score	0.752878 (rank : 345)	θ value	3.41135e-07 (rank : 394)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1560	Shared Neighborhood Hits	789
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

HUNK_HUMAN
NC score	0.752610 (rank : 346)	θ value	7.09661e-13 (rank : 184)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	764
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

TGFR2_HUMAN
NC score	0.752486 (rank : 347)	θ value	6.21693e-09 (rank : 311)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	701
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

PLK3_MOUSE
NC score	0.752437 (rank : 348)	θ value	8.11959e-09 (rank : 314)
Query Neighborhood Hits	1243	Target Neighborhood Hits	863	Shared Neighborhood Hits	761
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

HUNK_MOUSE
NC score	0.752432 (rank : 349)	θ value	2.43908e-13 (rank : 177)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	764
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

TNIK_HUMAN
NC score	0.752043 (rank : 350)	θ value	1.17247e-07 (rank : 370)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1570	Shared Neighborhood Hits	808
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

CHK1_MOUSE
NC score	0.751809 (rank : 351)	θ value	2.13673e-09 (rank : 284)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	756
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

SN1L1_MOUSE
NC score	0.751501 (rank : 352)	θ value	6.43352e-06 (rank : 482)
Query Neighborhood Hits	1243	Target Neighborhood Hits	895	Shared Neighborhood Hits	766
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

PLK3_HUMAN
NC score	0.751445 (rank : 353)	θ value	8.11959e-09 (rank : 313)
Query Neighborhood Hits	1243	Target Neighborhood Hits	865	Shared Neighborhood Hits	760
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

TSSK4_HUMAN
NC score	0.751434 (rank : 354)	θ value	6.43352e-06 (rank : 485)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	750
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TGFR2_MOUSE
NC score	0.751224 (rank : 355)	θ value	1.38499e-08 (rank : 320)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	701
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

M4K2_MOUSE
NC score	0.751179 (rank : 356)	θ value	1.25267e-09 (rank : 279)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	756
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

SN1L2_MOUSE
NC score	0.750835 (rank : 357)	θ value	1.09739e-05 (rank : 503)
Query Neighborhood Hits	1243	Target Neighborhood Hits	944	Shared Neighborhood Hits	779
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

STK11_HUMAN
NC score	0.750233 (rank : 358)	θ value	6.43352e-06 (rank : 484)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	749
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

AURKB_HUMAN
NC score	0.749657 (rank : 359)	θ value	1.53129e-07 (rank : 371)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	759
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

M4K2_HUMAN
NC score	0.749035 (rank : 360)	θ value	2.13673e-09 (rank : 285)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	758
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

MAK_MOUSE
NC score	0.748927 (rank : 361)	θ value	6.87365e-08 (rank : 353)
Query Neighborhood Hits	1243	Target Neighborhood Hits	873	Shared Neighborhood Hits	759
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

IKKE_HUMAN
NC score	0.748857 (rank : 362)	θ value	1.09739e-05 (rank : 495)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	740
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

AURKB_MOUSE
NC score	0.748770 (rank : 363)	θ value	9.59137e-10 (rank : 268)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	763
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

ICK_MOUSE
NC score	0.748720 (rank : 364)	θ value	8.97725e-08 (rank : 359)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	756
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MP2K6_HUMAN
NC score	0.748604 (rank : 365)	θ value	0.000602161 (rank : 610)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	749
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

ICK_HUMAN
NC score	0.748466 (rank : 366)	θ value	1.99992e-07 (rank : 375)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	755
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

IKKE_MOUSE
NC score	0.747881 (rank : 367)	θ value	0.00035302 (rank : 590)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	740
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

E2AK3_MOUSE
NC score	0.747845 (rank : 368)	θ value	0.00390308 (rank : 668)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	753
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

PKN1_HUMAN
NC score	0.747407 (rank : 369)	θ value	6.00763e-12 (rank : 196)
Query Neighborhood Hits	1243	Target Neighborhood Hits	886	Shared Neighborhood Hits	762
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

NIM1_MOUSE
NC score	0.747380 (rank : 370)	θ value	2.28291e-11 (rank : 212)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	755
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

MP2K3_MOUSE
NC score	0.747291 (rank : 371)	θ value	0.00035302 (rank : 595)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	749
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K6_MOUSE
NC score	0.747276 (rank : 372)	θ value	0.00228821 (rank : 647)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	750
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PDK1L_MOUSE
NC score	0.747228 (rank : 373)	θ value	5.81887e-07 (rank : 412)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	744
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

E2AK3_HUMAN
NC score	0.747170 (rank : 374)	θ value	0.00665767 (rank : 683)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	750
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

PKN1_MOUSE
NC score	0.747163 (rank : 375)	θ value	2.69671e-12 (rank : 193)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	756
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

M4K5_MOUSE
NC score	0.747140 (rank : 376)	θ value	1.29631e-06 (rank : 438)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	754
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

LRRK1_MOUSE
NC score	0.747105 (rank : 377)	θ value	θ > 10 (rank : 1398)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1267	Shared Neighborhood Hits	751
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

BMPR2_MOUSE
NC score	0.746956 (rank : 378)	θ value	2.79066e-09 (rank : 290)
Query Neighborhood Hits	1243	Target Neighborhood Hits	738	Shared Neighborhood Hits	679
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

MYLK2_HUMAN
NC score	0.746896 (rank : 379)	θ value	3.41135e-07 (rank : 395)
Query Neighborhood Hits	1243	Target Neighborhood Hits	920	Shared Neighborhood Hits	766
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PDK1L_HUMAN
NC score	0.746795 (rank : 380)	θ value	5.81887e-07 (rank : 411)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	744
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

M4K5_HUMAN
NC score	0.746704 (rank : 381)	θ value	6.43352e-06 (rank : 479)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	756
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

SN1L1_HUMAN
NC score	0.746690 (rank : 382)	θ value	3.19293e-05 (rank : 529)
Query Neighborhood Hits	1243	Target Neighborhood Hits	911	Shared Neighborhood Hits	770
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

MP2K3_HUMAN
NC score	0.746680 (rank : 383)	θ value	0.00134147 (rank : 636)
Query Neighborhood Hits	1243	Target Neighborhood Hits	825	Shared Neighborhood Hits	749
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TAOK3_MOUSE
NC score	0.746539 (rank : 384)	θ value	8.67504e-11 (rank : 235)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1458	Shared Neighborhood Hits	776
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAOK3_HUMAN
NC score	0.746485 (rank : 385)	θ value	1.74796e-11 (rank : 209)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1494	Shared Neighborhood Hits	781
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

MAK_HUMAN
NC score	0.746388 (rank : 386)	θ value	1.17247e-07 (rank : 366)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	755
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PLK1_MOUSE
NC score	0.745105 (rank : 387)	θ value	5.62301e-10 (rank : 260)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

SLK_MOUSE
NC score	0.743873 (rank : 388)	θ value	4.30538e-10 (rank : 256)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1798	Shared Neighborhood Hits	797
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

LRRK1_HUMAN
NC score	0.743762 (rank : 389)	θ value	θ > 10 (rank : 1397)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1237	Shared Neighborhood Hits	749
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

PKN2_HUMAN
NC score	0.743367 (rank : 390)	θ value	5.43371e-13 (rank : 181)
Query Neighborhood Hits	1243	Target Neighborhood Hits	892	Shared Neighborhood Hits	753
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

ACV1B_MOUSE
NC score	0.743226 (rank : 391)	θ value	2.79066e-09 (rank : 289)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	713
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

K0999_MOUSE
NC score	0.742960 (rank : 392)	θ value	3.41135e-07 (rank : 392)
Query Neighborhood Hits	1243	Target Neighborhood Hits	931	Shared Neighborhood Hits	777
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

ACV1B_HUMAN
NC score	0.742875 (rank : 393)	θ value	2.79066e-09 (rank : 288)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	713
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

SLK_HUMAN
NC score	0.742854 (rank : 394)	θ value	1.47974e-10 (rank : 241)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1775	Shared Neighborhood Hits	796
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

PKN2_MOUSE
NC score	0.742382 (rank : 395)	θ value	5.43371e-13 (rank : 182)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	752
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

K0999_HUMAN
NC score	0.742333 (rank : 396)	θ value	7.59969e-07 (rank : 419)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	764
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KKCC2_MOUSE
NC score	0.740485 (rank : 397)	θ value	7.1131e-05 (rank : 546)
Query Neighborhood Hits	1243	Target Neighborhood Hits	855	Shared Neighborhood Hits	757
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.740200 (rank : 398)	θ value	7.1131e-05 (rank : 545)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	756
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

IRAK3_MOUSE
NC score	0.740004 (rank : 399)	θ value	θ > 10 (rank : 1363)
Query Neighborhood Hits	1243	Target Neighborhood Hits	628	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TSSK1_MOUSE
NC score	0.739951 (rank : 400)	θ value	2.21117e-06 (rank : 454)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	752
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MELK_MOUSE
NC score	0.739849 (rank : 401)	θ value	4.0297e-08 (rank : 342)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	758
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

CDC2_HUMAN
NC score	0.739646 (rank : 402)	θ value	7.59969e-07 (rank : 415)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	756
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

M4K4_HUMAN
NC score	0.739432 (rank : 403)	θ value	5.81887e-07 (rank : 409)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1589	Shared Neighborhood Hits	783
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

E2AK1_HUMAN
NC score	0.738355 (rank : 404)	θ value	0.0563607 (rank : 757)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	741
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MELK_HUMAN
NC score	0.738161 (rank : 405)	θ value	1.99992e-07 (rank : 381)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	757
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

KS6A3_MOUSE
NC score	0.737617 (rank : 406)	θ value	1.47974e-10 (rank : 239)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	762
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A2_HUMAN
NC score	0.737587 (rank : 407)	θ value	1.06045e-08 (rank : 316)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	761
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
NC score	0.737371 (rank : 408)	θ value	5.62301e-10 (rank : 259)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	762
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PRKY_HUMAN
NC score	0.737352 (rank : 409)	θ value	7.59969e-07 (rank : 424)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	759
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

KS6A1_HUMAN
NC score	0.737215 (rank : 410)	θ value	2.36244e-08 (rank : 326)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	759
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KPCT_HUMAN
NC score	0.737093 (rank : 411)	θ value	1.63604e-09 (rank : 281)
Query Neighborhood Hits	1243	Target Neighborhood Hits	897	Shared Neighborhood Hits	758
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CD2L7_HUMAN
NC score	0.736987 (rank : 412)	θ value	0.00298849 (rank : 650)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1275	Shared Neighborhood Hits	836
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDK6_MOUSE
NC score	0.736784 (rank : 413)	θ value	2.88788e-06 (rank : 455)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	749
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CD2L5_HUMAN
NC score	0.736567 (rank : 414)	θ value	0.00390308 (rank : 665)
Query Neighborhood Hits	1243	Target Neighborhood Hits	987	Shared Neighborhood Hits	770
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
NC score	0.736414 (rank : 415)	θ value	0.00390308 (rank : 666)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1011	Shared Neighborhood Hits	772
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

KS6A2_MOUSE
NC score	0.736320 (rank : 416)	θ value	6.21693e-09 (rank : 306)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	762
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

E2AK1_MOUSE
NC score	0.736202 (rank : 417)	θ value	0.0563607 (rank : 758)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	739
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CDC2_MOUSE
NC score	0.736179 (rank : 418)	θ value	1.69304e-06 (rank : 443)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	754
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

TAOK1_HUMAN
NC score	0.736119 (rank : 419)	θ value	2.28291e-11 (rank : 213)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1734	Shared Neighborhood Hits	796
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
NC score	0.735730 (rank : 420)	θ value	2.28291e-11 (rank : 214)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1720	Shared Neighborhood Hits	793
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

CDK2_MOUSE
NC score	0.735517 (rank : 421)	θ value	4.1701e-05 (rank : 531)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	749
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

AVR2A_MOUSE
NC score	0.735330 (rank : 422)	θ value	0.000461057 (rank : 599)
Query Neighborhood Hits	1243	Target Neighborhood Hits	767	Shared Neighborhood Hits	714
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

CDK3_MOUSE
NC score	0.735324 (rank : 423)	θ value	3.19293e-05 (rank : 522)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	750
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

AVR2A_HUMAN
NC score	0.735318 (rank : 424)	θ value	0.000461057 (rank : 598)
Query Neighborhood Hits	1243	Target Neighborhood Hits	767	Shared Neighborhood Hits	714
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

ST17B_MOUSE
NC score	0.735250 (rank : 425)	θ value	0.000786445 (rank : 622)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

CDKL2_HUMAN
NC score	0.735074 (rank : 426)	θ value	1.80886e-08 (rank : 321)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

TSSK2_HUMAN
NC score	0.735038 (rank : 427)	θ value	7.59969e-07 (rank : 427)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	748
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

BRSK2_HUMAN
NC score	0.734909 (rank : 428)	θ value	0.000786445 (rank : 613)
Query Neighborhood Hits	1243	Target Neighborhood Hits	897	Shared Neighborhood Hits	764
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

TBK1_HUMAN
NC score	0.734783 (rank : 429)	θ value	1.09739e-05 (rank : 504)
Query Neighborhood Hits	1243	Target Neighborhood Hits	861	Shared Neighborhood Hits	734
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

CDK3_HUMAN
NC score	0.734601 (rank : 430)	θ value	0.00020696 (rank : 575)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	753
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDKL2_MOUSE
NC score	0.734381 (rank : 431)	θ value	5.26297e-08 (rank : 346)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	750
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDK6_HUMAN
NC score	0.733813 (rank : 432)	θ value	8.40245e-06 (rank : 487)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	749
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

KPCD_HUMAN
NC score	0.733690 (rank : 433)	θ value	6.21693e-09 (rank : 303)
Query Neighborhood Hits	1243	Target Neighborhood Hits	900	Shared Neighborhood Hits	759
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_MOUSE
NC score	0.733638 (rank : 434)	θ value	1.25267e-09 (rank : 278)
Query Neighborhood Hits	1243	Target Neighborhood Hits	895	Shared Neighborhood Hits	757
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

AL2S7_HUMAN
NC score	0.733233 (rank : 435)	θ value	9.29e-05 (rank : 552)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	744
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CDK2_HUMAN
NC score	0.733051 (rank : 436)	θ value	0.000461057 (rank : 601)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	754
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

TBK1_MOUSE
NC score	0.732933 (rank : 437)	θ value	1.09739e-05 (rank : 505)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	734
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

PKN3_MOUSE
NC score	0.732859 (rank : 438)	θ value	5.08577e-11 (rank : 226)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1009	Shared Neighborhood Hits	797
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

CI096_HUMAN
NC score	0.732446 (rank : 439)	θ value	0.125558 (rank : 797)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	727
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

BRSK1_HUMAN
NC score	0.732090 (rank : 440)	θ value	0.00102713 (rank : 624)
Query Neighborhood Hits	1243	Target Neighborhood Hits	942	Shared Neighborhood Hits	775
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PDPK1_MOUSE
NC score	0.731648 (rank : 441)	θ value	1.43324e-05 (rank : 510)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	754
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

ACV1C_HUMAN
NC score	0.731356 (rank : 442)	θ value	8.97725e-08 (rank : 356)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	668
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CDK9_HUMAN
NC score	0.731302 (rank : 443)	θ value	1.25267e-09 (rank : 277)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	746
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
NC score	0.731280 (rank : 444)	θ value	9.59137e-10 (rank : 269)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	746
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

ACV1C_MOUSE
NC score	0.731049 (rank : 445)	θ value	4.76016e-09 (rank : 295)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	673
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

PDPK1_HUMAN
NC score	0.730854 (rank : 446)	θ value	1.43324e-05 (rank : 509)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	753
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

CDKL4_MOUSE
NC score	0.730585 (rank : 447)	θ value	8.97725e-08 (rank : 358)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	749
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KS6A6_HUMAN
NC score	0.729290 (rank : 448)	θ value	8.97725e-08 (rank : 360)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

STK10_HUMAN
NC score	0.729252 (rank : 449)	θ value	1.99992e-07 (rank : 385)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1921	Shared Neighborhood Hits	840
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

E2AK4_HUMAN
NC score	0.729040 (rank : 450)	θ value	0.000121331 (rank : 563)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1012	Shared Neighborhood Hits	770
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

CDKL3_HUMAN
NC score	0.728929 (rank : 451)	θ value	1.43324e-05 (rank : 506)
Query Neighborhood Hits	1243	Target Neighborhood Hits	853	Shared Neighborhood Hits	751
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDK4_MOUSE
NC score	0.728869 (rank : 452)	θ value	3.19293e-05 (rank : 523)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	750
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

TSSK6_MOUSE
NC score	0.728202 (rank : 453)	θ value	0.000121331 (rank : 567)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	744
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

GUC2C_HUMAN
NC score	0.727303 (rank : 454)	θ value	0.21417 (rank : 819)
Query Neighborhood Hits	1243	Target Neighborhood Hits	624	Shared Neighborhood Hits	560
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

PCTK2_MOUSE
NC score	0.727189 (rank : 455)	θ value	8.97725e-08 (rank : 362)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	748
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

DAPK3_MOUSE
NC score	0.726862 (rank : 456)	θ value	2.88788e-06 (rank : 456)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	739
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_HUMAN
NC score	0.726795 (rank : 457)	θ value	1.09739e-05 (rank : 494)
Query Neighborhood Hits	1243	Target Neighborhood Hits	945	Shared Neighborhood Hits	743
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

PCTK2_HUMAN
NC score	0.726763 (rank : 458)	θ value	8.97725e-08 (rank : 361)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

TSSK6_HUMAN
NC score	0.726507 (rank : 459)	θ value	0.00035302 (rank : 597)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	743
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PCTK1_MOUSE
NC score	0.726457 (rank : 460)	θ value	1.53129e-07 (rank : 374)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	748
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

CDK5_MOUSE
NC score	0.726432 (rank : 461)	θ value	7.59969e-07 (rank : 417)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK5_HUMAN
NC score	0.726141 (rank : 462)	θ value	7.59969e-07 (rank : 416)
Query Neighborhood Hits	1243	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

ST32A_MOUSE
NC score	0.726026 (rank : 463)	θ value	6.87365e-08 (rank : 354)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	750
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

CDKL3_MOUSE
NC score	0.725996 (rank : 464)	θ value	2.44474e-05 (rank : 519)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	750
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KKCC1_HUMAN
NC score	0.725124 (rank : 465)	θ value	0.0113563 (rank : 700)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	761
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCD_MOUSE
NC score	0.725101 (rank : 466)	θ value	3.41135e-07 (rank : 393)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	756
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

PFTK1_MOUSE
NC score	0.725098 (rank : 467)	θ value	0.00298849 (rank : 659)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	744
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PCTK1_HUMAN
NC score	0.724959 (rank : 468)	θ value	1.99992e-07 (rank : 383)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	750
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PKN3_HUMAN
NC score	0.724423 (rank : 469)	θ value	5.08577e-11 (rank : 225)
Query Neighborhood Hits	1243	Target Neighborhood Hits	893	Shared Neighborhood Hits	763
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PFTK1_HUMAN
NC score	0.724231 (rank : 470)	θ value	0.00390308 (rank : 672)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	744
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

ST17B_HUMAN
NC score	0.724054 (rank : 471)	θ value	0.000121331 (rank : 566)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	743
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KKCC1_MOUSE
NC score	0.723991 (rank : 472)	θ value	0.0252991 (rank : 728)
Query Neighborhood Hits	1243	Target Neighborhood Hits	866	Shared Neighborhood Hits	762
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

CDK4_HUMAN
NC score	0.723517 (rank : 473)	θ value	0.000121331 (rank : 562)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	748
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

DAPK2_MOUSE
NC score	0.723017 (rank : 474)	θ value	4.92598e-06 (rank : 467)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	743
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

PCTK3_MOUSE
NC score	0.722551 (rank : 475)	θ value	6.43352e-06 (rank : 480)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	749
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PRKX_MOUSE
NC score	0.722275 (rank : 476)	θ value	2.79066e-09 (rank : 292)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	759
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

WNK1_HUMAN
NC score	0.721913 (rank : 477)	θ value	θ > 10 (rank : 1623)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1158	Shared Neighborhood Hits	777
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

SBK1_MOUSE
NC score	0.721839 (rank : 478)	θ value	3.19293e-05 (rank : 527)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	734
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

PRKX_HUMAN
NC score	0.721442 (rank : 479)	θ value	4.45536e-07 (rank : 405)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	759
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

IRAK3_HUMAN
NC score	0.721262 (rank : 480)	θ value	8.99809 (rank : 1210)
Query Neighborhood Hits	1243	Target Neighborhood Hits	644	Shared Neighborhood Hits	597
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

WNK1_MOUSE
NC score	0.721206 (rank : 481)	θ value	θ > 10 (rank : 1624)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1179	Shared Neighborhood Hits	783
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

PCTK3_HUMAN
NC score	0.720565 (rank : 482)	θ value	7.59969e-07 (rank : 423)
Query Neighborhood Hits	1243	Target Neighborhood Hits	827	Shared Neighborhood Hits	746
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDKL4_HUMAN
NC score	0.720441 (rank : 483)	θ value	9.92553e-07 (rank : 429)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	745
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDK7_MOUSE
NC score	0.720397 (rank : 484)	θ value	0.0113563 (rank : 695)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	749
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

WNK3_HUMAN
NC score	0.720093 (rank : 485)	θ value	θ > 10 (rank : 1625)
Query Neighborhood Hits	1243	Target Neighborhood Hits	948	Shared Neighborhood Hits	728
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

DAPK2_HUMAN
NC score	0.719749 (rank : 486)	θ value	4.92598e-06 (rank : 466)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	739
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

WNK4_MOUSE
NC score	0.719384 (rank : 487)	θ value	2.52405e-10 (rank : 250)
Query Neighborhood Hits	1243	Target Neighborhood Hits	961	Shared Neighborhood Hits	744
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MK07_MOUSE
NC score	0.719239 (rank : 488)	θ value	7.59969e-07 (rank : 422)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1054	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

ST32A_HUMAN
NC score	0.719111 (rank : 489)	θ value	1.06045e-08 (rank : 318)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	750
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

MK07_HUMAN
NC score	0.719102 (rank : 490)	θ value	5.81887e-07 (rank : 410)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1087	Shared Neighborhood Hits	818
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

SNRK_MOUSE
NC score	0.719046 (rank : 491)	θ value	0.00020696 (rank : 580)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	742
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

CDK7_HUMAN
NC score	0.718962 (rank : 492)	θ value	0.0113563 (rank : 694)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	749
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

MASTL_MOUSE
NC score	0.718879 (rank : 493)	θ value	2.61198e-07 (rank : 388)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	752
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

KS6A1_MOUSE
NC score	0.718726 (rank : 494)	θ value	4.45536e-07 (rank : 400)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	756
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

CDK10_HUMAN
NC score	0.718669 (rank : 495)	θ value	6.43352e-06 (rank : 474)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	747
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

TSSK2_MOUSE
NC score	0.717920 (rank : 496)	θ value	9.29e-05 (rank : 560)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	743
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

SNRK_HUMAN
NC score	0.717740 (rank : 497)	θ value	0.000602161 (rank : 612)
Query Neighborhood Hits	1243	Target Neighborhood Hits	855	Shared Neighborhood Hits	741
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SBK1_HUMAN
NC score	0.717192 (rank : 498)	θ value	9.92553e-07 (rank : 433)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	736
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

WNK4_HUMAN
NC score	0.717038 (rank : 499)	θ value	3.29651e-10 (rank : 254)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1043	Shared Neighborhood Hits	760
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK2_HUMAN
NC score	0.716936 (rank : 500)	θ value	0.21417 (rank : 827)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1407	Shared Neighborhood Hits	858
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

E2AK4_MOUSE
NC score	0.716235 (rank : 501)	θ value	9.29e-05 (rank : 553)
Query Neighborhood Hits	1243	Target Neighborhood Hits	984	Shared Neighborhood Hits	767
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

KPCA_MOUSE
NC score	0.715455 (rank : 502)	θ value	5.08577e-11 (rank : 224)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1067	Shared Neighborhood Hits	757
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MASTL_HUMAN
NC score	0.714863 (rank : 503)	θ value	1.99992e-07 (rank : 380)
Query Neighborhood Hits	1243	Target Neighborhood Hits	894	Shared Neighborhood Hits	757
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

ST17A_HUMAN
NC score	0.714728 (rank : 504)	θ value	1.87187e-05 (rank : 517)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	739
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

KS6B1_MOUSE
NC score	0.713818 (rank : 505)	θ value	4.1701e-05 (rank : 534)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	757
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.713738 (rank : 506)	θ value	4.1701e-05 (rank : 533)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	757
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KCC1G_MOUSE
NC score	0.713369 (rank : 507)	θ value	1.29631e-06 (rank : 437)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	756
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_HUMAN
NC score	0.712965 (rank : 508)	θ value	2.21117e-06 (rank : 449)
Query Neighborhood Hits	1243	Target Neighborhood Hits	850	Shared Neighborhood Hits	753
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

NLK_MOUSE
NC score	0.712044 (rank : 509)	θ value	0.62314 (rank : 895)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	754
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.711960 (rank : 510)	θ value	0.62314 (rank : 894)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	754
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

PASK_MOUSE
NC score	0.711762 (rank : 511)	θ value	0.0431538 (rank : 748)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	748
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

ST32B_MOUSE
NC score	0.711624 (rank : 512)	θ value	7.59969e-07 (rank : 425)
Query Neighborhood Hits	1243	Target Neighborhood Hits	828	Shared Neighborhood Hits	746
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

PASK_HUMAN
NC score	0.711487 (rank : 513)	θ value	0.00509761 (rank : 681)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	750
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

TSSK1_HUMAN
NC score	0.711402 (rank : 514)	θ value	9.29e-05 (rank : 559)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	744
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MK03_HUMAN
NC score	0.711115 (rank : 515)	θ value	0.000158464 (rank : 570)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	752
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

KPCA_HUMAN
NC score	0.711051 (rank : 516)	θ value	1.133e-10 (rank : 236)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1070	Shared Neighborhood Hits	759
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KAPCG_HUMAN
NC score	0.710998 (rank : 517)	θ value	1.09739e-05 (rank : 496)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	754
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

DCAK3_MOUSE
NC score	0.710914 (rank : 518)	θ value	9.92553e-07 (rank : 430)
Query Neighborhood Hits	1243	Target Neighborhood Hits	922	Shared Neighborhood Hits	762
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

LRRK2_HUMAN
NC score	0.710304 (rank : 519)	θ value	θ > 10 (rank : 1399)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1382	Shared Neighborhood Hits	754
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

MK03_MOUSE
NC score	0.709944 (rank : 520)	θ value	0.00020696 (rank : 577)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	752
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

GRK4_MOUSE
NC score	0.709890 (rank : 521)	θ value	7.1131e-05 (rank : 544)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	736
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

MK01_MOUSE
NC score	0.709730 (rank : 522)	θ value	0.00175202 (rank : 640)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	751
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

CDKL1_HUMAN
NC score	0.709547 (rank : 523)	θ value	5.81887e-07 (rank : 408)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	749
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

SGK1_HUMAN
NC score	0.709490 (rank : 524)	θ value	4.92598e-06 (rank : 471)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	755
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

GRK6_HUMAN
NC score	0.709487 (rank : 525)	θ value	4.92598e-06 (rank : 468)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	745
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MK01_HUMAN
NC score	0.709468 (rank : 526)	θ value	0.00134147 (rank : 635)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	751
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

GRK6_MOUSE
NC score	0.709383 (rank : 527)	θ value	6.43352e-06 (rank : 475)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	746
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KPCD2_HUMAN
NC score	0.709195 (rank : 528)	θ value	3.19293e-05 (rank : 525)
Query Neighborhood Hits	1243	Target Neighborhood Hits	910	Shared Neighborhood Hits	753
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

ST32B_HUMAN
NC score	0.709120 (rank : 529)	θ value	2.21117e-06 (rank : 453)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	747
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

CDKL5_HUMAN
NC score	0.708809 (rank : 530)	θ value	1.09739e-05 (rank : 493)
Query Neighborhood Hits	1243	Target Neighborhood Hits	967	Shared Neighborhood Hits	770
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

KS6B2_HUMAN
NC score	0.708637 (rank : 531)	θ value	1.69304e-06 (rank : 445)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	765
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

SGK1_MOUSE
NC score	0.708495 (rank : 532)	θ value	6.43352e-06 (rank : 481)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	756
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

KPCB_MOUSE
NC score	0.708482 (rank : 533)	θ value	1.99992e-07 (rank : 378)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1117	Shared Neighborhood Hits	761
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

CCRK_HUMAN
NC score	0.708282 (rank : 534)	θ value	5.26297e-08 (rank : 345)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	752
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

STK10_MOUSE
NC score	0.708212 (rank : 535)	θ value	4.45536e-07 (rank : 406)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2132	Shared Neighborhood Hits	837
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

KCC1A_HUMAN
NC score	0.708174 (rank : 536)	θ value	0.000270298 (rank : 583)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	752
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

DCAK3_HUMAN
NC score	0.708165 (rank : 537)	θ value	0.000158464 (rank : 568)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	755
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KCC1A_MOUSE
NC score	0.707893 (rank : 538)	θ value	0.000270298 (rank : 584)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	752
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

AKT3_HUMAN
NC score	0.707872 (rank : 539)	θ value	4.76016e-09 (rank : 296)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	758
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.707842 (rank : 540)	θ value	4.76016e-09 (rank : 297)
Query Neighborhood Hits	1243	Target Neighborhood Hits	872	Shared Neighborhood Hits	758
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

M3K8_HUMAN
NC score	0.707019 (rank : 541)	θ value	θ > 10 (rank : 1404)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	720
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

KPCB_HUMAN
NC score	0.706984 (rank : 542)	θ value	1.99992e-07 (rank : 377)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1121	Shared Neighborhood Hits	761
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KCC1B_MOUSE
NC score	0.706380 (rank : 543)	θ value	0.00035302 (rank : 591)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	751
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

ERN1_HUMAN
NC score	0.705834 (rank : 544)	θ value	0.0736092 (rank : 764)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	738
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KPCE_MOUSE
NC score	0.705775 (rank : 545)	θ value	1.47974e-10 (rank : 238)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	752
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

DCAK1_HUMAN
NC score	0.705712 (rank : 546)	θ value	5.26297e-08 (rank : 347)
Query Neighborhood Hits	1243	Target Neighborhood Hits	877	Shared Neighborhood Hits	756
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

AKT2_MOUSE
NC score	0.705576 (rank : 547)	θ value	4.45536e-07 (rank : 398)
Query Neighborhood Hits	1243	Target Neighborhood Hits	875	Shared Neighborhood Hits	757
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_HUMAN
NC score	0.705508 (rank : 548)	θ value	4.45536e-07 (rank : 397)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	757
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CDKL1_MOUSE
NC score	0.705422 (rank : 549)	θ value	8.97725e-08 (rank : 357)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	746
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

IRAK2_HUMAN
NC score	0.705261 (rank : 550)	θ value	0.0113563 (rank : 699)
Query Neighborhood Hits	1243	Target Neighborhood Hits	714	Shared Neighborhood Hits	647
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

DCAK1_MOUSE
NC score	0.705237 (rank : 551)	θ value	4.0297e-08 (rank : 338)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	752
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

CD2L2_HUMAN
NC score	0.704993 (rank : 552)	θ value	0.00035302 (rank : 588)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1439	Shared Neighborhood Hits	778
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

KCC1B_HUMAN
NC score	0.704972 (rank : 553)	θ value	0.000602161 (rank : 607)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	751
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KPCE_HUMAN
NC score	0.704965 (rank : 554)	θ value	9.59137e-10 (rank : 271)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	752
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

M3K8_MOUSE
NC score	0.704612 (rank : 555)	θ value	θ > 10 (rank : 1405)
Query Neighborhood Hits	1243	Target Neighborhood Hits	815	Shared Neighborhood Hits	723
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

AVR2B_MOUSE
NC score	0.704236 (rank : 556)	θ value	1.87187e-05 (rank : 513)
Query Neighborhood Hits	1243	Target Neighborhood Hits	749	Shared Neighborhood Hits	702
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.704013 (rank : 557)	θ value	1.87187e-05 (rank : 512)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	702
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

MK14_HUMAN
NC score	0.703968 (rank : 558)	θ value	0.00035302 (rank : 593)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	753
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

CD2L1_MOUSE
NC score	0.703867 (rank : 559)	θ value	0.00020696 (rank : 574)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1463	Shared Neighborhood Hits	775
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

GRK4_HUMAN
NC score	0.703614 (rank : 560)	θ value	9.29e-05 (rank : 554)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	738
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

CD2L1_HUMAN
NC score	0.703468 (rank : 561)	θ value	0.000461057 (rank : 600)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1467	Shared Neighborhood Hits	777
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

KS6B2_MOUSE
NC score	0.703350 (rank : 562)	θ value	2.88788e-06 (rank : 459)
Query Neighborhood Hits	1243	Target Neighborhood Hits	871	Shared Neighborhood Hits	764
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KPSH2_HUMAN
NC score	0.703288 (rank : 563)	θ value	θ > 10 (rank : 1384)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	735
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC1D_MOUSE
NC score	0.703164 (rank : 564)	θ value	4.92598e-06 (rank : 470)
Query Neighborhood Hits	1243	Target Neighborhood Hits	847	Shared Neighborhood Hits	750
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.703159 (rank : 565)	θ value	4.92598e-06 (rank : 469)
Query Neighborhood Hits	1243	Target Neighborhood Hits	846	Shared Neighborhood Hits	750
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

ST32C_MOUSE
NC score	0.702847 (rank : 566)	θ value	9.29e-05 (rank : 558)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	743
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

MK14_MOUSE
NC score	0.702634 (rank : 567)	θ value	0.00102713 (rank : 629)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	753
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK12_HUMAN
NC score	0.701900 (rank : 568)	θ value	0.000270298 (rank : 585)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	749
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

ERN1_MOUSE
NC score	0.701887 (rank : 569)	θ value	0.00298849 (rank : 653)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	736
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

GRK5_MOUSE
NC score	0.701581 (rank : 570)	θ value	1.87187e-05 (rank : 515)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	739
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_HUMAN
NC score	0.701378 (rank : 571)	θ value	1.87187e-05 (rank : 514)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	739
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

CCRK_MOUSE
NC score	0.701061 (rank : 572)	θ value	3.77169e-06 (rank : 462)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	750
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

KPSH1_MOUSE
NC score	0.700843 (rank : 573)	θ value	7.59969e-07 (rank : 421)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	745
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPCD1_HUMAN
NC score	0.700766 (rank : 574)	θ value	0.00102713 (rank : 628)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	749
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KAPCB_HUMAN
NC score	0.700372 (rank : 575)	θ value	9.29e-05 (rank : 555)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	753
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

AL2S2_HUMAN
NC score	0.700111 (rank : 576)	θ value	θ > 10 (rank : 1248)
Query Neighborhood Hits	1243	Target Neighborhood Hits	727	Shared Neighborhood Hits	673
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

MK12_MOUSE
NC score	0.700054 (rank : 577)	θ value	0.000602161 (rank : 609)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	751
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK15_HUMAN
NC score	0.700038 (rank : 578)	θ value	0.000461057 (rank : 604)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1038	Shared Neighborhood Hits	813
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

KPSH1_HUMAN
NC score	0.699461 (rank : 579)	θ value	1.09739e-05 (rank : 497)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	744
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

DCAK2_MOUSE
NC score	0.699295 (rank : 580)	θ value	2.61198e-07 (rank : 386)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	750
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

MK04_HUMAN
NC score	0.699104 (rank : 581)	θ value	0.0193708 (rank : 721)
Query Neighborhood Hits	1243	Target Neighborhood Hits	837	Shared Neighborhood Hits	741
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

M3K14_HUMAN
NC score	0.698934 (rank : 582)	θ value	8.99809 (rank : 1219)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	755
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

PHKG2_MOUSE
NC score	0.698867 (rank : 583)	θ value	1.29631e-06 (rank : 441)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	752
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

KAPCA_HUMAN
NC score	0.698740 (rank : 584)	θ value	3.19293e-05 (rank : 524)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	753
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_MOUSE
NC score	0.698736 (rank : 585)	θ value	5.44631e-05 (rank : 539)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	753
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_MOUSE
NC score	0.698187 (rank : 586)	θ value	0.000158464 (rank : 569)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	751
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KPCD1_MOUSE
NC score	0.698109 (rank : 587)	θ value	0.00134147 (rank : 634)
Query Neighborhood Hits	1243	Target Neighborhood Hits	891	Shared Neighborhood Hits	748
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

ST32C_HUMAN
NC score	0.698064 (rank : 588)	θ value	0.00020696 (rank : 581)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	746
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

AKT1_HUMAN
NC score	0.697745 (rank : 589)	θ value	3.41135e-07 (rank : 389)
Query Neighborhood Hits	1243	Target Neighborhood Hits	885	Shared Neighborhood Hits	755
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KPCL_MOUSE
NC score	0.696693 (rank : 590)	θ value	3.08544e-08 (rank : 330)
Query Neighborhood Hits	1243	Target Neighborhood Hits	891	Shared Neighborhood Hits	753
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCD3_HUMAN
NC score	0.696649 (rank : 591)	θ value	0.00035302 (rank : 592)
Query Neighborhood Hits	1243	Target Neighborhood Hits	895	Shared Neighborhood Hits	748
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

SGK2_HUMAN
NC score	0.696617 (rank : 592)	θ value	3.19293e-05 (rank : 528)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	752
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

AKT1_MOUSE
NC score	0.696529 (rank : 593)	θ value	7.59969e-07 (rank : 414)
Query Neighborhood Hits	1243	Target Neighborhood Hits	878	Shared Neighborhood Hits	756
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

SGK2_MOUSE
NC score	0.696433 (rank : 594)	θ value	4.1701e-05 (rank : 536)
Query Neighborhood Hits	1243	Target Neighborhood Hits	833	Shared Neighborhood Hits	749
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

MK04_MOUSE
NC score	0.696326 (rank : 595)	θ value	0.0961366 (rank : 782)
Query Neighborhood Hits	1243	Target Neighborhood Hits	852	Shared Neighborhood Hits	747
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

AMHR2_HUMAN
NC score	0.695869 (rank : 596)	θ value	2.44474e-05 (rank : 518)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	646
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

RK_MOUSE
NC score	0.695671 (rank : 597)	θ value	2.21117e-06 (rank : 452)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	744
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

LRRK2_MOUSE
NC score	0.695205 (rank : 598)	θ value	θ > 10 (rank : 1400)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1359	Shared Neighborhood Hits	747
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

KPCD3_MOUSE
NC score	0.695137 (rank : 599)	θ value	0.000602161 (rank : 608)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	745
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

RK_HUMAN
NC score	0.695068 (rank : 600)	θ value	8.97725e-08 (rank : 363)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	746
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KGP1A_HUMAN
NC score	0.695067 (rank : 601)	θ value	0.0148317 (rank : 709)
Query Neighborhood Hits	1243	Target Neighborhood Hits	901	Shared Neighborhood Hits	756
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

DCAK2_HUMAN
NC score	0.694875 (rank : 602)	θ value	1.29631e-06 (rank : 435)
Query Neighborhood Hits	1243	Target Neighborhood Hits	862	Shared Neighborhood Hits	752
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KGP1B_MOUSE
NC score	0.694644 (rank : 603)	θ value	0.0148317 (rank : 711)
Query Neighborhood Hits	1243	Target Neighborhood Hits	922	Shared Neighborhood Hits	757
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.694608 (rank : 604)	θ value	0.0148317 (rank : 710)
Query Neighborhood Hits	1243	Target Neighborhood Hits	921	Shared Neighborhood Hits	757
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MK11_HUMAN
NC score	0.694512 (rank : 605)	θ value	0.00869519 (rank : 691)
Query Neighborhood Hits	1243	Target Neighborhood Hits	823	Shared Neighborhood Hits	745
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

TTK_HUMAN
NC score	0.693553 (rank : 606)	θ value	5.44631e-05 (rank : 542)
Query Neighborhood Hits	1243	Target Neighborhood Hits	816	Shared Neighborhood Hits	707
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

KPCL_HUMAN
NC score	0.692820 (rank : 607)	θ value	6.87365e-08 (rank : 351)
Query Neighborhood Hits	1243	Target Neighborhood Hits	887	Shared Neighborhood Hits	753
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

SGK3_MOUSE
NC score	0.692564 (rank : 608)	θ value	2.44474e-05 (rank : 520)
Query Neighborhood Hits	1243	Target Neighborhood Hits	882	Shared Neighborhood Hits	752
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

AL2S2_MOUSE
NC score	0.692161 (rank : 609)	θ value	θ > 10 (rank : 1249)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	655
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

MK13_HUMAN
NC score	0.692015 (rank : 610)	θ value	0.0736092 (rank : 767)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	750
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

ANPRB_HUMAN
NC score	0.691835 (rank : 611)	θ value	2.36244e-08 (rank : 325)
Query Neighborhood Hits	1243	Target Neighborhood Hits	646	Shared Neighborhood Hits	561
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

KCC2G_HUMAN
NC score	0.691832 (rank : 612)	θ value	9.29e-05 (rank : 556)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	748
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

ANPRA_HUMAN
NC score	0.691821 (rank : 613)	θ value	1.25267e-09 (rank : 276)
Query Neighborhood Hits	1243	Target Neighborhood Hits	612	Shared Neighborhood Hits	527
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

KCC2G_MOUSE
NC score	0.691808 (rank : 614)	θ value	9.29e-05 (rank : 557)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KGP2_HUMAN
NC score	0.691469 (rank : 615)	θ value	0.00298849 (rank : 656)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1023	Shared Neighborhood Hits	769
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PMYT1_MOUSE
NC score	0.691459 (rank : 616)	θ value	6.88961 (rank : 1165)
Query Neighborhood Hits	1243	Target Neighborhood Hits	910	Shared Neighborhood Hits	781
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KS6A5_HUMAN
NC score	0.691311 (rank : 617)	θ value	5.26297e-08 (rank : 349)
Query Neighborhood Hits	1243	Target Neighborhood Hits	855	Shared Neighborhood Hits	758
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

ANKK1_MOUSE
NC score	0.691242 (rank : 618)	θ value	6.43352e-06 (rank : 473)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1072	Shared Neighborhood Hits	742
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

KS6A4_MOUSE
NC score	0.690957 (rank : 619)	θ value	3.77169e-06 (rank : 464)
Query Neighborhood Hits	1243	Target Neighborhood Hits	866	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MK13_MOUSE
NC score	0.690887 (rank : 620)	θ value	0.0736092 (rank : 768)
Query Neighborhood Hits	1243	Target Neighborhood Hits	832	Shared Neighborhood Hits	752
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

PHKG2_HUMAN
NC score	0.690399 (rank : 621)	θ value	2.88788e-06 (rank : 460)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	752
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

KPCG_MOUSE
NC score	0.690382 (rank : 622)	θ value	7.59969e-07 (rank : 420)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1123	Shared Neighborhood Hits	757
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

ANPRA_MOUSE
NC score	0.690336 (rank : 623)	θ value	8.67504e-11 (rank : 230)
Query Neighborhood Hits	1243	Target Neighborhood Hits	600	Shared Neighborhood Hits	523
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

RIPK4_HUMAN
NC score	0.690152 (rank : 624)	θ value	5.62301e-10 (rank : 261)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1094	Shared Neighborhood Hits	744
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

KGP2_MOUSE
NC score	0.690015 (rank : 625)	θ value	0.00665767 (rank : 684)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1029	Shared Neighborhood Hits	765
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

SGK3_HUMAN
NC score	0.689981 (rank : 626)	θ value	0.000270298 (rank : 587)
Query Neighborhood Hits	1243	Target Neighborhood Hits	877	Shared Neighborhood Hits	752
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

KPCG_HUMAN
NC score	0.689819 (rank : 627)	θ value	4.45536e-07 (rank : 399)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1126	Shared Neighborhood Hits	757
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6A4_HUMAN
NC score	0.689813 (rank : 628)	θ value	6.43352e-06 (rank : 477)
Query Neighborhood Hits	1243	Target Neighborhood Hits	868	Shared Neighborhood Hits	765
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A5_MOUSE
NC score	0.689718 (rank : 629)	θ value	6.87365e-08 (rank : 352)
Query Neighborhood Hits	1243	Target Neighborhood Hits	854	Shared Neighborhood Hits	758
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MK11_MOUSE
NC score	0.689538 (rank : 630)	θ value	0.00175202 (rank : 641)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	748
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

CHK2_MOUSE
NC score	0.688255 (rank : 631)	θ value	0.00390308 (rank : 667)
Query Neighborhood Hits	1243	Target Neighborhood Hits	860	Shared Neighborhood Hits	752
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KCC2A_HUMAN
NC score	0.687269 (rank : 632)	θ value	8.40245e-06 (rank : 488)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	742
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

GAK_HUMAN
NC score	0.686827 (rank : 633)	θ value	0.000461057 (rank : 602)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1028	Shared Neighborhood Hits	803
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KPCI_HUMAN
NC score	0.686433 (rank : 634)	θ value	1.80886e-08 (rank : 322)
Query Neighborhood Hits	1243	Target Neighborhood Hits	885	Shared Neighborhood Hits	756
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

MOK_HUMAN
NC score	0.686321 (rank : 635)	θ value	0.00020696 (rank : 579)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	724
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

KPCI_MOUSE
NC score	0.685890 (rank : 636)	θ value	1.80886e-08 (rank : 323)
Query Neighborhood Hits	1243	Target Neighborhood Hits	888	Shared Neighborhood Hits	756
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MOK_MOUSE
NC score	0.685314 (rank : 637)	θ value	0.000786445 (rank : 618)
Query Neighborhood Hits	1243	Target Neighborhood Hits	796	Shared Neighborhood Hits	719
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

KCC4_HUMAN
NC score	0.685036 (rank : 638)	θ value	0.125558 (rank : 799)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	747
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MK06_HUMAN
NC score	0.684410 (rank : 639)	θ value	0.00228821 (rank : 645)
Query Neighborhood Hits	1243	Target Neighborhood Hits	815	Shared Neighborhood Hits	718
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.684276 (rank : 640)	θ value	0.00390308 (rank : 671)
Query Neighborhood Hits	1243	Target Neighborhood Hits	818	Shared Neighborhood Hits	719
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

KCC2A_MOUSE
NC score	0.684247 (rank : 641)	θ value	1.87187e-05 (rank : 516)
Query Neighborhood Hits	1243	Target Neighborhood Hits	829	Shared Neighborhood Hits	740
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

PHKG1_HUMAN
NC score	0.683538 (rank : 642)	θ value	2.36244e-08 (rank : 329)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	754
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

BMP2K_HUMAN
NC score	0.683450 (rank : 643)	θ value	9.92553e-07 (rank : 428)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	721
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

KCC2B_HUMAN
NC score	0.683418 (rank : 644)	θ value	2.88788e-06 (rank : 457)
Query Neighborhood Hits	1243	Target Neighborhood Hits	866	Shared Neighborhood Hits	754
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
NC score	0.683343 (rank : 645)	θ value	4.1701e-05 (rank : 532)
Query Neighborhood Hits	1243	Target Neighborhood Hits	830	Shared Neighborhood Hits	742
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

MK10_MOUSE
NC score	0.682981 (rank : 646)	θ value	7.1131e-05 (rank : 548)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	751
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_HUMAN
NC score	0.682698 (rank : 647)	θ value	7.1131e-05 (rank : 547)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	749
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

CHK2_HUMAN
NC score	0.682629 (rank : 648)	θ value	0.00035302 (rank : 589)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	749
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

TSSK3_MOUSE
NC score	0.682586 (rank : 649)	θ value	5.44631e-05 (rank : 541)
Query Neighborhood Hits	1243	Target Neighborhood Hits	806	Shared Neighborhood Hits	732
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

M3K14_MOUSE
NC score	0.682284 (rank : 650)	θ value	4.03905 (rank : 1073)
Query Neighborhood Hits	1243	Target Neighborhood Hits	889	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

ANKK1_HUMAN
NC score	0.681569 (rank : 651)	θ value	3.41135e-07 (rank : 390)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1075	Shared Neighborhood Hits	736
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

KCC4_MOUSE
NC score	0.681488 (rank : 652)	θ value	0.0736092 (rank : 766)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	750
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

ERN2_MOUSE
NC score	0.681408 (rank : 653)	θ value	0.000786445 (rank : 617)
Query Neighborhood Hits	1243	Target Neighborhood Hits	825	Shared Neighborhood Hits	736
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KCC2B_MOUSE
NC score	0.681200 (rank : 654)	θ value	2.88788e-06 (rank : 458)
Query Neighborhood Hits	1243	Target Neighborhood Hits	841	Shared Neighborhood Hits	741
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

ILK_MOUSE
NC score	0.681093 (rank : 655)	θ value	3.77169e-06 (rank : 463)
Query Neighborhood Hits	1243	Target Neighborhood Hits	858	Shared Neighborhood Hits	570
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

PHKG1_MOUSE
NC score	0.680880 (rank : 656)	θ value	1.29631e-06 (rank : 440)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	754
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TSSK3_HUMAN
NC score	0.680672 (rank : 657)	θ value	9.29e-05 (rank : 561)
Query Neighborhood Hits	1243	Target Neighborhood Hits	806	Shared Neighborhood Hits	732
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

ERN2_HUMAN
NC score	0.680644 (rank : 658)	θ value	0.00175202 (rank : 639)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	741
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ILK1_HUMAN
NC score	0.679849 (rank : 659)	θ value	6.43352e-06 (rank : 476)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	569
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

TLK2_HUMAN
NC score	0.679701 (rank : 660)	θ value	θ > 10 (rank : 1598)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1044	Shared Neighborhood Hits	727
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

PIM2_HUMAN
NC score	0.679354 (rank : 661)	θ value	0.47712 (rank : 876)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	732
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

GUC2G_MOUSE
NC score	0.678813 (rank : 662)	θ value	5.44631e-05 (rank : 538)
Query Neighborhood Hits	1243	Target Neighborhood Hits	644	Shared Neighborhood Hits	571
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

MK08_MOUSE
NC score	0.678638 (rank : 663)	θ value	0.000121331 (rank : 565)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	750
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK08_HUMAN
NC score	0.678097 (rank : 664)	θ value	0.000121331 (rank : 564)
Query Neighborhood Hits	1243	Target Neighborhood Hits	834	Shared Neighborhood Hits	750
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

WEE1_MOUSE
NC score	0.678063 (rank : 665)	θ value	5.44631e-05 (rank : 543)
Query Neighborhood Hits	1243	Target Neighborhood Hits	794	Shared Neighborhood Hits	691
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

TLK2_MOUSE
NC score	0.677948 (rank : 666)	θ value	θ > 10 (rank : 1599)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1088	Shared Neighborhood Hits	730
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TTK_MOUSE
NC score	0.677938 (rank : 667)	θ value	4.1701e-05 (rank : 537)
Query Neighborhood Hits	1243	Target Neighborhood Hits	803	Shared Neighborhood Hits	694
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

MK15_MOUSE
NC score	0.677734 (rank : 668)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	747
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MK09_HUMAN
NC score	0.677651 (rank : 669)	θ value	1.43324e-05 (rank : 508)
Query Neighborhood Hits	1243	Target Neighborhood Hits	842	Shared Neighborhood Hits	752
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

PMYT1_HUMAN
NC score	0.676571 (rank : 670)	θ value	θ > 10 (rank : 1497)
Query Neighborhood Hits	1243	Target Neighborhood Hits	814	Shared Neighborhood Hits	733
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KPCZ_MOUSE
NC score	0.675940 (rank : 671)	θ value	6.21693e-09 (rank : 305)
Query Neighborhood Hits	1243	Target Neighborhood Hits	882	Shared Neighborhood Hits	754
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.675873 (rank : 672)	θ value	6.21693e-09 (rank : 304)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	755
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MYLK_HUMAN
NC score	0.675477 (rank : 673)	θ value	1.29631e-06 (rank : 439)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1328	Shared Neighborhood Hits	770
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
NC score	0.675294 (rank : 674)	θ value	3.41135e-07 (rank : 396)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1489	Shared Neighborhood Hits	841
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MK09_MOUSE
NC score	0.675054 (rank : 675)	θ value	3.19293e-05 (rank : 526)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	751
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

GRK7_HUMAN
NC score	0.672830 (rank : 676)	θ value	0.00102713 (rank : 627)
Query Neighborhood Hits	1243	Target Neighborhood Hits	820	Shared Neighborhood Hits	745
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GUC2D_HUMAN
NC score	0.672529 (rank : 677)	θ value	0.000461057 (rank : 603)
Query Neighborhood Hits	1243	Target Neighborhood Hits	715	Shared Neighborhood Hits	645
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

BMP2K_MOUSE
NC score	0.671403 (rank : 678)	θ value	4.1701e-05 (rank : 530)
Query Neighborhood Hits	1243	Target Neighborhood Hits	874	Shared Neighborhood Hits	720
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

PIM2_MOUSE
NC score	0.671066 (rank : 679)	θ value	0.0431538 (rank : 750)
Query Neighborhood Hits	1243	Target Neighborhood Hits	809	Shared Neighborhood Hits	729
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

TLK1_HUMAN
NC score	0.670800 (rank : 680)	θ value	θ > 10 (rank : 1596)
Query Neighborhood Hits	1243	Target Neighborhood Hits	967	Shared Neighborhood Hits	715
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

ANPRB_MOUSE
NC score	0.670800 (rank : 681)	θ value	1.17247e-07 (rank : 364)
Query Neighborhood Hits	1243	Target Neighborhood Hits	607	Shared Neighborhood Hits	536
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

MAPK3_MOUSE
NC score	0.670282 (rank : 682)	θ value	0.0193708 (rank : 720)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	729
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

GUC2E_MOUSE
NC score	0.670114 (rank : 683)	θ value	0.00228821 (rank : 644)
Query Neighborhood Hits	1243	Target Neighborhood Hits	692	Shared Neighborhood Hits	623
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

TLK1_MOUSE
NC score	0.670060 (rank : 684)	θ value	θ > 10 (rank : 1597)
Query Neighborhood Hits	1243	Target Neighborhood Hits	947	Shared Neighborhood Hits	710
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

CD2L6_MOUSE
NC score	0.670032 (rank : 685)	θ value	0.000786445 (rank : 615)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	747
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.669906 (rank : 686)	θ value	0.000786445 (rank : 614)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	744
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

GAK_MOUSE
NC score	0.669743 (rank : 687)	θ value	0.000602161 (rank : 606)
Query Neighborhood Hits	1243	Target Neighborhood Hits	964	Shared Neighborhood Hits	765
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MAST3_HUMAN
NC score	0.669084 (rank : 688)	θ value	0.0113563 (rank : 701)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1128	Shared Neighborhood Hits	814
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAPK2_HUMAN
NC score	0.667631 (rank : 689)	θ value	0.163984 (rank : 809)
Query Neighborhood Hits	1243	Target Neighborhood Hits	844	Shared Neighborhood Hits	743
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

ULK4_MOUSE
NC score	0.665609 (rank : 690)	θ value	0.00298849 (rank : 663)
Query Neighborhood Hits	1243	Target Neighborhood Hits	793	Shared Neighborhood Hits	706
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

CDK8_HUMAN
NC score	0.665250 (rank : 691)	θ value	0.00509761 (rank : 678)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	741
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

MAST4_HUMAN
NC score	0.664988 (rank : 692)	θ value	0.0113563 (rank : 702)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1804	Shared Neighborhood Hits	963
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

TEX14_MOUSE
NC score	0.664923 (rank : 693)	θ value	0.0563607 (rank : 762)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1333	Shared Neighborhood Hits	643
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MAPK2_MOUSE
NC score	0.664735 (rank : 694)	θ value	0.163984 (rank : 810)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	739
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MYO3A_MOUSE
NC score	0.663875 (rank : 695)	θ value	2.36244e-08 (rank : 327)
Query Neighborhood Hits	1243	Target Neighborhood Hits	902	Shared Neighborhood Hits	752
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

GSK3A_HUMAN
NC score	0.661627 (rank : 696)	θ value	θ > 10 (rank : 1354)
Query Neighborhood Hits	1243	Target Neighborhood Hits	835	Shared Neighborhood Hits	739
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

AAK1_MOUSE
NC score	0.661407 (rank : 697)	θ value	0.000602161 (rank : 605)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1051	Shared Neighborhood Hits	799
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ILK2_HUMAN
NC score	0.661301 (rank : 698)	θ value	1.29631e-06 (rank : 436)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	561
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MYO3A_HUMAN
NC score	0.661244 (rank : 699)	θ value	1.06045e-08 (rank : 317)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1033	Shared Neighborhood Hits	760
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

PINK1_MOUSE
NC score	0.660902 (rank : 700)	θ value	0.0961366 (rank : 787)
Query Neighborhood Hits	1243	Target Neighborhood Hits	726	Shared Neighborhood Hits	678
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

MAPK3_HUMAN
NC score	0.660791 (rank : 701)	θ value	0.0252991 (rank : 729)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	723
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAST2_MOUSE
NC score	0.660790 (rank : 702)	θ value	0.365318 (rank : 857)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1110	Shared Neighborhood Hits	794
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.659994 (rank : 703)	θ value	0.365318 (rank : 856)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1189	Shared Neighborhood Hits	820
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

UHMK1_MOUSE
NC score	0.659309 (rank : 704)	θ value	0.0252991 (rank : 736)
Query Neighborhood Hits	1243	Target Neighborhood Hits	809	Shared Neighborhood Hits	698
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_HUMAN
NC score	0.658290 (rank : 705)	θ value	0.0252991 (rank : 735)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	698
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

AAK1_HUMAN
NC score	0.658137 (rank : 706)	θ value	θ > 10 (rank : 1244)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1077	Shared Neighborhood Hits	797
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

MAST1_HUMAN
NC score	0.657843 (rank : 707)	θ value	0.163984 (rank : 811)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1146	Shared Neighborhood Hits	815
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
NC score	0.657488 (rank : 708)	θ value	0.163984 (rank : 812)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1123	Shared Neighborhood Hits	813
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ARBK1_HUMAN
NC score	0.655159 (rank : 709)	θ value	0.279714 (rank : 829)
Query Neighborhood Hits	1243	Target Neighborhood Hits	859	Shared Neighborhood Hits	748
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

PIM3_HUMAN
NC score	0.653752 (rank : 710)	θ value	0.0252991 (rank : 732)
Query Neighborhood Hits	1243	Target Neighborhood Hits	789	Shared Neighborhood Hits	716
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

DAPK1_HUMAN
NC score	0.653242 (rank : 711)	θ value	1.69304e-06 (rank : 444)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1130	Shared Neighborhood Hits	751
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

WEE1_HUMAN
NC score	0.653225 (rank : 712)	θ value	2.44474e-05 (rank : 521)
Query Neighborhood Hits	1243	Target Neighborhood Hits	777	Shared Neighborhood Hits	671
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

F5006_MOUSE
NC score	0.652086 (rank : 713)	θ value	4.03905 (rank : 1068)
Query Neighborhood Hits	1243	Target Neighborhood Hits	793	Shared Neighborhood Hits	727
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

PIM1_HUMAN
NC score	0.652014 (rank : 714)	θ value	0.47712 (rank : 875)
Query Neighborhood Hits	1243	Target Neighborhood Hits	797	Shared Neighborhood Hits	715
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

DAPK1_MOUSE
NC score	0.651135 (rank : 715)	θ value	7.59969e-07 (rank : 418)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1138	Shared Neighborhood Hits	751
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

GSK3B_HUMAN
NC score	0.650968 (rank : 716)	θ value	θ > 10 (rank : 1355)
Query Neighborhood Hits	1243	Target Neighborhood Hits	801	Shared Neighborhood Hits	726
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.650941 (rank : 717)	θ value	θ > 10 (rank : 1356)
Query Neighborhood Hits	1243	Target Neighborhood Hits	800	Shared Neighborhood Hits	725
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MYO3B_HUMAN
NC score	0.650362 (rank : 718)	θ value	3.77169e-06 (rank : 465)
Query Neighborhood Hits	1243	Target Neighborhood Hits	923	Shared Neighborhood Hits	756
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

ARBK1_MOUSE
NC score	0.650169 (rank : 719)	θ value	0.21417 (rank : 815)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	746
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

PIM1_MOUSE
NC score	0.648270 (rank : 720)	θ value	0.0961366 (rank : 786)
Query Neighborhood Hits	1243	Target Neighborhood Hits	787	Shared Neighborhood Hits	708
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

SPEG_HUMAN
NC score	0.648128 (rank : 721)	θ value	0.00390308 (rank : 675)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1762	Shared Neighborhood Hits	905
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
NC score	0.644918 (rank : 722)	θ value	0.000158464 (rank : 572)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1959	Shared Neighborhood Hits	950
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PIM3_MOUSE
NC score	0.644893 (rank : 723)	θ value	0.0252991 (rank : 733)
Query Neighborhood Hits	1243	Target Neighborhood Hits	783	Shared Neighborhood Hits	711
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

ARBK2_HUMAN
NC score	0.644406 (rank : 724)	θ value	1.06291 (rank : 927)
Query Neighborhood Hits	1243	Target Neighborhood Hits	849	Shared Neighborhood Hits	746
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

HIPK4_HUMAN
NC score	0.643940 (rank : 725)	θ value	θ > 10 (rank : 1358)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	716
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

MKNK2_HUMAN
NC score	0.642451 (rank : 726)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	740
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

CSKP_MOUSE
NC score	0.637828 (rank : 727)	θ value	θ > 10 (rank : 1309)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1027	Shared Neighborhood Hits	738
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

MKNK2_MOUSE
NC score	0.637534 (rank : 728)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	1243	Target Neighborhood Hits	819	Shared Neighborhood Hits	739
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

CSKP_HUMAN
NC score	0.635905 (rank : 729)	θ value	θ > 10 (rank : 1308)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1022	Shared Neighborhood Hits	737
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

TEX14_HUMAN
NC score	0.633446 (rank : 730)	θ value	θ > 10 (rank : 1594)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1103	Shared Neighborhood Hits	581
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CAMKV_MOUSE
NC score	0.629726 (rank : 731)	θ value	θ > 10 (rank : 1267)
Query Neighborhood Hits	1243	Target Neighborhood Hits	848	Shared Neighborhood Hits	719
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

STK38_MOUSE
NC score	0.629433 (rank : 732)	θ value	0.000158464 (rank : 573)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	727
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

F5006_HUMAN
NC score	0.628660 (rank : 733)	θ value	1.81305 (rank : 977)
Query Neighborhood Hits	1243	Target Neighborhood Hits	794	Shared Neighborhood Hits	722
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

STK38_HUMAN
NC score	0.628658 (rank : 734)	θ value	0.00020696 (rank : 582)
Query Neighborhood Hits	1243	Target Neighborhood Hits	840	Shared Neighborhood Hits	727
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

CAMKV_HUMAN
NC score	0.628632 (rank : 735)	θ value	θ > 10 (rank : 1266)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1084	Shared Neighborhood Hits	776
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

DMPK_MOUSE
NC score	0.628160 (rank : 736)	θ value	0.00175202 (rank : 638)
Query Neighborhood Hits	1243	Target Neighborhood Hits	908	Shared Neighborhood Hits	747
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

WEE1B_MOUSE
NC score	0.628043 (rank : 737)	θ value	0.00390308 (rank : 676)
Query Neighborhood Hits	1243	Target Neighborhood Hits	765	Shared Neighborhood Hits	675
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

OBSCN_HUMAN
NC score	0.627987 (rank : 738)	θ value	4.1701e-05 (rank : 535)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1931	Shared Neighborhood Hits	927
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

DMPK_HUMAN
NC score	0.625786 (rank : 739)	θ value	0.00228821 (rank : 643)
Query Neighborhood Hits	1243	Target Neighborhood Hits	944	Shared Neighborhood Hits	750
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ST38L_HUMAN
NC score	0.623457 (rank : 740)	θ value	0.00035302 (rank : 596)
Query Neighborhood Hits	1243	Target Neighborhood Hits	824	Shared Neighborhood Hits	721
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

LATS1_HUMAN
NC score	0.622212 (rank : 741)	θ value	0.00298849 (rank : 657)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1057	Shared Neighborhood Hits	795
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

WEE1B_HUMAN
NC score	0.621507 (rank : 742)	θ value	0.0736092 (rank : 774)
Query Neighborhood Hits	1243	Target Neighborhood Hits	836	Shared Neighborhood Hits	683
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

MKNK1_MOUSE
NC score	0.621501 (rank : 743)	θ value	0.00020696 (rank : 578)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	723
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MRCKG_MOUSE
NC score	0.618255 (rank : 744)	θ value	0.0330416 (rank : 739)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1466	Shared Neighborhood Hits	769
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

LATS1_MOUSE
NC score	0.617000 (rank : 745)	θ value	0.00390308 (rank : 670)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1027	Shared Neighborhood Hits	775
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

TRIO_HUMAN
NC score	0.616572 (rank : 746)	θ value	0.00298849 (rank : 662)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1580	Shared Neighborhood Hits	788
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MRCKG_HUMAN
NC score	0.615918 (rank : 747)	θ value	0.0563607 (rank : 760)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1519	Shared Neighborhood Hits	781
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PINK1_HUMAN
NC score	0.615019 (rank : 748)	θ value	1.81305 (rank : 986)
Query Neighborhood Hits	1243	Target Neighborhood Hits	741	Shared Neighborhood Hits	681
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

LATS2_MOUSE
NC score	0.611375 (rank : 749)	θ value	0.21417 (rank : 821)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	759
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

HIPK3_MOUSE
NC score	0.609854 (rank : 750)	θ value	6.88961 (rank : 1148)
Query Neighborhood Hits	1243	Target Neighborhood Hits	857	Shared Neighborhood Hits	731
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

LATS2_HUMAN
NC score	0.609758 (rank : 751)	θ value	0.21417 (rank : 820)
Query Neighborhood Hits	1243	Target Neighborhood Hits	884	Shared Neighborhood Hits	757
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

HIPK3_HUMAN
NC score	0.608756 (rank : 752)	θ value	6.88961 (rank : 1147)
Query Neighborhood Hits	1243	Target Neighborhood Hits	867	Shared Neighborhood Hits	726
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

ST38L_MOUSE
NC score	0.608577 (rank : 753)	θ value	0.00298849 (rank : 661)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	715
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

PRP4B_HUMAN
NC score	0.606560 (rank : 754)	θ value	θ > 10 (rank : 1500)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1030	Shared Neighborhood Hits	710
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
NC score	0.605230 (rank : 755)	θ value	θ > 10 (rank : 1501)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1040	Shared Neighborhood Hits	708
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

MAPK5_MOUSE
NC score	0.605142 (rank : 756)	θ value	0.0330416 (rank : 738)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	717
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

HIPK1_HUMAN
NC score	0.604083 (rank : 757)	θ value	1.81305 (rank : 980)
Query Neighborhood Hits	1243	Target Neighborhood Hits	843	Shared Neighborhood Hits	713
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.603944 (rank : 758)	θ value	1.81305 (rank : 981)
Query Neighborhood Hits	1243	Target Neighborhood Hits	838	Shared Neighborhood Hits	713
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

DUET_HUMAN
NC score	0.601844 (rank : 759)	θ value	1.81305 (rank : 974)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1220	Shared Neighborhood Hits	751
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYRK3_HUMAN
NC score	0.601471 (rank : 760)	θ value	5.27518 (rank : 1100)
Query Neighborhood Hits	1243	Target Neighborhood Hits	798	Shared Neighborhood Hits	712
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

MAPK5_HUMAN
NC score	0.600237 (rank : 761)	θ value	0.0431538 (rank : 747)
Query Neighborhood Hits	1243	Target Neighborhood Hits	795	Shared Neighborhood Hits	713
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

CSK21_MOUSE
NC score	0.598825 (rank : 762)	θ value	θ > 10 (rank : 1303)
Query Neighborhood Hits	1243	Target Neighborhood Hits	770	Shared Neighborhood Hits	692
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_HUMAN
NC score	0.597836 (rank : 763)	θ value	θ > 10 (rank : 1302)
Query Neighborhood Hits	1243	Target Neighborhood Hits	772	Shared Neighborhood Hits	692
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

HIPK2_HUMAN
NC score	0.597522 (rank : 764)	θ value	2.36792 (rank : 1005)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	712
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.597449 (rank : 765)	θ value	2.36792 (rank : 1006)
Query Neighborhood Hits	1243	Target Neighborhood Hits	871	Shared Neighborhood Hits	720
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

CTRO_HUMAN
NC score	0.594691 (rank : 766)	θ value	0.00020696 (rank : 576)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2092	Shared Neighborhood Hits	811
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ROCK1_HUMAN
NC score	0.589964 (rank : 767)	θ value	7.1131e-05 (rank : 550)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2000	Shared Neighborhood Hits	797
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK2_HUMAN
NC score	0.587494 (rank : 768)	θ value	0.000270298 (rank : 586)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2073	Shared Neighborhood Hits	805
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

MRCKA_HUMAN
NC score	0.587058 (rank : 769)	θ value	0.0961366 (rank : 783)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1999	Shared Neighborhood Hits	795
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

STK40_HUMAN
NC score	0.584204 (rank : 770)	θ value	θ > 10 (rank : 1589)
Query Neighborhood Hits	1243	Target Neighborhood Hits	751	Shared Neighborhood Hits	675
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
NC score	0.583872 (rank : 771)	θ value	θ > 10 (rank : 1590)
Query Neighborhood Hits	1243	Target Neighborhood Hits	751	Shared Neighborhood Hits	676
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

ROCK2_MOUSE
NC score	0.580586 (rank : 772)	θ value	0.000786445 (rank : 621)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2072	Shared Neighborhood Hits	800
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

DYRK2_HUMAN
NC score	0.580546 (rank : 773)	θ value	6.88961 (rank : 1144)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	708
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

CSK22_MOUSE
NC score	0.577852 (rank : 774)	θ value	θ > 10 (rank : 1305)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	684
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

ROCK1_MOUSE
NC score	0.577553 (rank : 775)	θ value	7.1131e-05 (rank : 551)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2126	Shared Neighborhood Hits	799
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CSK22_HUMAN
NC score	0.576849 (rank : 776)	θ value	θ > 10 (rank : 1304)
Query Neighborhood Hits	1243	Target Neighborhood Hits	758	Shared Neighborhood Hits	684
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DYR1B_HUMAN
NC score	0.576783 (rank : 777)	θ value	θ > 10 (rank : 1323)
Query Neighborhood Hits	1243	Target Neighborhood Hits	831	Shared Neighborhood Hits	714
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

CTRO_MOUSE
NC score	0.576423 (rank : 778)	θ value	0.00102713 (rank : 625)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2344	Shared Neighborhood Hits	829
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DYR1B_MOUSE
NC score	0.575570 (rank : 779)	θ value	8.99809 (rank : 1202)
Query Neighborhood Hits	1243	Target Neighborhood Hits	799	Shared Neighborhood Hits	702
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

MRCKB_MOUSE
NC score	0.575335 (rank : 780)	θ value	0.00298849 (rank : 658)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2180	Shared Neighborhood Hits	815
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_HUMAN
NC score	0.569872 (rank : 781)	θ value	0.0113563 (rank : 703)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2239	Shared Neighborhood Hits	823
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TTBK1_HUMAN
NC score	0.562455 (rank : 782)	θ value	θ > 10 (rank : 1603)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1058	Shared Neighborhood Hits	699
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

DYR1A_HUMAN
NC score	0.559040 (rank : 783)	θ value	θ > 10 (rank : 1321)
Query Neighborhood Hits	1243	Target Neighborhood Hits	764	Shared Neighborhood Hits	682
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.559026 (rank : 784)	θ value	θ > 10 (rank : 1322)
Query Neighborhood Hits	1243	Target Neighborhood Hits	762	Shared Neighborhood Hits	682
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

KC1D_HUMAN
NC score	0.557616 (rank : 785)	θ value	0.00298849 (rank : 654)
Query Neighborhood Hits	1243	Target Neighborhood Hits	737	Shared Neighborhood Hits	661
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.557615 (rank : 786)	θ value	0.00298849 (rank : 655)
Query Neighborhood Hits	1243	Target Neighborhood Hits	737	Shared Neighborhood Hits	661
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_MOUSE
NC score	0.554297 (rank : 787)	θ value	0.00134147 (rank : 633)
Query Neighborhood Hits	1243	Target Neighborhood Hits	728	Shared Neighborhood Hits	659
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_HUMAN
NC score	0.554282 (rank : 788)	θ value	0.00134147 (rank : 632)
Query Neighborhood Hits	1243	Target Neighborhood Hits	732	Shared Neighborhood Hits	659
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

CLK4_HUMAN
NC score	0.551405 (rank : 789)	θ value	0.0113563 (rank : 696)
Query Neighborhood Hits	1243	Target Neighborhood Hits	759	Shared Neighborhood Hits	686
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK1_MOUSE
NC score	0.550515 (rank : 790)	θ value	0.000786445 (rank : 616)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	679
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK4_MOUSE
NC score	0.550076 (rank : 791)	θ value	0.0193708 (rank : 717)
Query Neighborhood Hits	1243	Target Neighborhood Hits	759	Shared Neighborhood Hits	684
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

TITIN_HUMAN
NC score	0.545024 (rank : 792)	θ value	θ > 10 (rank : 1595)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2923	Shared Neighborhood Hits	857
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TRIB2_HUMAN
NC score	0.543336 (rank : 793)	θ value	0.0193708 (rank : 722)
Query Neighborhood Hits	1243	Target Neighborhood Hits	657	Shared Neighborhood Hits	611
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

CLK1_HUMAN
NC score	0.543248 (rank : 794)	θ value	0.00509761 (rank : 679)
Query Neighborhood Hits	1243	Target Neighborhood Hits	756	Shared Neighborhood Hits	671
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

TRIB2_MOUSE
NC score	0.541785 (rank : 795)	θ value	0.0193708 (rank : 723)
Query Neighborhood Hits	1243	Target Neighborhood Hits	653	Shared Neighborhood Hits	607
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

DYRK4_HUMAN
NC score	0.541712 (rank : 796)	θ value	θ > 10 (rank : 1324)
Query Neighborhood Hits	1243	Target Neighborhood Hits	750	Shared Neighborhood Hits	672
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

TTBK2_MOUSE
NC score	0.541416 (rank : 797)	θ value	θ > 10 (rank : 1605)
Query Neighborhood Hits	1243	Target Neighborhood Hits	811	Shared Neighborhood Hits	643
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTBK2_HUMAN
NC score	0.541268 (rank : 798)	θ value	θ > 10 (rank : 1604)
Query Neighborhood Hits	1243	Target Neighborhood Hits	822	Shared Neighborhood Hits	647
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

CLK2_HUMAN
NC score	0.525101 (rank : 799)	θ value	3.0926 (rank : 1031)
Query Neighborhood Hits	1243	Target Neighborhood Hits	752	Shared Neighborhood Hits	670
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK3_HUMAN
NC score	0.517012 (rank : 800)	θ value	θ > 10 (rank : 1283)
Query Neighborhood Hits	1243	Target Neighborhood Hits	748	Shared Neighborhood Hits	663
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.516702 (rank : 801)	θ value	θ > 10 (rank : 1284)
Query Neighborhood Hits	1243	Target Neighborhood Hits	761	Shared Neighborhood Hits	663
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

KC1AL_HUMAN
NC score	0.516267 (rank : 802)	θ value	8.99809 (rank : 1214)
Query Neighborhood Hits	1243	Target Neighborhood Hits	734	Shared Neighborhood Hits	661
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

MKNK1_HUMAN
NC score	0.516020 (rank : 803)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	1243	Target Neighborhood Hits	701	Shared Neighborhood Hits	626
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

KC1A_HUMAN
NC score	0.509749 (rank : 804)	θ value	0.47712 (rank : 871)
Query Neighborhood Hits	1243	Target Neighborhood Hits	728	Shared Neighborhood Hits	659
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.509749 (rank : 805)	θ value	0.47712 (rank : 872)
Query Neighborhood Hits	1243	Target Neighborhood Hits	728	Shared Neighborhood Hits	659
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1G1_MOUSE
NC score	0.509382 (rank : 806)	θ value	θ > 10 (rank : 1377)
Query Neighborhood Hits	1243	Target Neighborhood Hits	713	Shared Neighborhood Hits	643
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

CLK2_MOUSE
NC score	0.507863 (rank : 807)	θ value	3.0926 (rank : 1032)
Query Neighborhood Hits	1243	Target Neighborhood Hits	743	Shared Neighborhood Hits	664
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

KC1G1_HUMAN
NC score	0.507571 (rank : 808)	θ value	θ > 10 (rank : 1376)
Query Neighborhood Hits	1243	Target Neighborhood Hits	708	Shared Neighborhood Hits	641
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G3_HUMAN
NC score	0.502661 (rank : 809)	θ value	θ > 10 (rank : 1380)
Query Neighborhood Hits	1243	Target Neighborhood Hits	711	Shared Neighborhood Hits	643
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

RPKL1_MOUSE
NC score	0.501746 (rank : 810)	θ value	θ > 10 (rank : 1530)
Query Neighborhood Hits	1243	Target Neighborhood Hits	704	Shared Neighborhood Hits	622
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_HUMAN
NC score	0.496823 (rank : 811)	θ value	θ > 10 (rank : 1529)
Query Neighborhood Hits	1243	Target Neighborhood Hits	708	Shared Neighborhood Hits	626
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TRIB1_MOUSE
NC score	0.491443 (rank : 812)	θ value	0.0330416 (rank : 743)
Query Neighborhood Hits	1243	Target Neighborhood Hits	593	Shared Neighborhood Hits	543
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB1_HUMAN
NC score	0.491164 (rank : 813)	θ value	0.00869519 (rank : 693)
Query Neighborhood Hits	1243	Target Neighborhood Hits	598	Shared Neighborhood Hits	542
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

NRBP_MOUSE
NC score	0.475121 (rank : 814)	θ value	θ > 10 (rank : 1462)
Query Neighborhood Hits	1243	Target Neighborhood Hits	442	Shared Neighborhood Hits	392
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

TRIB3_MOUSE
NC score	0.474880 (rank : 815)	θ value	0.0736092 (rank : 772)
Query Neighborhood Hits	1243	Target Neighborhood Hits	578	Shared Neighborhood Hits	531
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

KC1G2_HUMAN
NC score	0.474134 (rank : 816)	θ value	θ > 10 (rank : 1378)
Query Neighborhood Hits	1243	Target Neighborhood Hits	693	Shared Neighborhood Hits	628
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

NRBP_HUMAN
NC score	0.473910 (rank : 817)	θ value	θ > 10 (rank : 1461)
Query Neighborhood Hits	1243	Target Neighborhood Hits	448	Shared Neighborhood Hits	397
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

KC1G2_MOUSE
NC score	0.471388 (rank : 818)	θ value	θ > 10 (rank : 1379)
Query Neighborhood Hits	1243	Target Neighborhood Hits	695	Shared Neighborhood Hits	627
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

SCYL2_HUMAN
NC score	0.466738 (rank : 819)	θ value	θ > 10 (rank : 1531)
Query Neighborhood Hits	1243	Target Neighborhood Hits	632	Shared Neighborhood Hits	532
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

KS6C1_MOUSE
NC score	0.457985 (rank : 820)	θ value	2.36792 (rank : 1009)
Query Neighborhood Hits	1243	Target Neighborhood Hits	700	Shared Neighborhood Hits	588
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KS6C1_HUMAN
NC score	0.452701 (rank : 821)	θ value	5.27518 (rank : 1105)
Query Neighborhood Hits	1243	Target Neighborhood Hits	682	Shared Neighborhood Hits	592
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

CDC7_HUMAN
NC score	0.452121 (rank : 822)	θ value	θ > 10 (rank : 1270)
Query Neighborhood Hits	1243	Target Neighborhood Hits	652	Shared Neighborhood Hits	571
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

SCYL2_MOUSE
NC score	0.449656 (rank : 823)	θ value	θ > 10 (rank : 1532)
Query Neighborhood Hits	1243	Target Neighborhood Hits	603	Shared Neighborhood Hits	510
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TRIB3_HUMAN
NC score	0.443289 (rank : 824)	θ value	θ > 10 (rank : 1602)
Query Neighborhood Hits	1243	Target Neighborhood Hits	519	Shared Neighborhood Hits	482
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

CDC7_MOUSE
NC score	0.434048 (rank : 825)	θ value	θ > 10 (rank : 1271)
Query Neighborhood Hits	1243	Target Neighborhood Hits	641	Shared Neighborhood Hits	567
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

VRK2_MOUSE
NC score	0.383417 (rank : 826)	θ value	0.0193708 (rank : 724)
Query Neighborhood Hits	1243	Target Neighborhood Hits	586	Shared Neighborhood Hits	540
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_HUMAN
NC score	0.378009 (rank : 827)	θ value	2.36792 (rank : 1019)
Query Neighborhood Hits	1243	Target Neighborhood Hits	582	Shared Neighborhood Hits	523
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_MOUSE
NC score	0.368605 (rank : 828)	θ value	θ > 10 (rank : 1621)
Query Neighborhood Hits	1243	Target Neighborhood Hits	583	Shared Neighborhood Hits	532
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK1_HUMAN
NC score	0.359411 (rank : 829)	θ value	θ > 10 (rank : 1620)
Query Neighborhood Hits	1243	Target Neighborhood Hits	584	Shared Neighborhood Hits	536
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

BUB1_MOUSE
NC score	0.351318 (rank : 830)	θ value	θ > 10 (rank : 1265)
Query Neighborhood Hits	1243	Target Neighborhood Hits	583	Shared Neighborhood Hits	473
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

SRPK1_MOUSE
NC score	0.323479 (rank : 831)	θ value	θ > 10 (rank : 1574)
Query Neighborhood Hits	1243	Target Neighborhood Hits	639	Shared Neighborhood Hits	508
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_HUMAN
NC score	0.323367 (rank : 832)	θ value	θ > 10 (rank : 1573)
Query Neighborhood Hits	1243	Target Neighborhood Hits	706	Shared Neighborhood Hits	526
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

STK23_MOUSE
NC score	0.315131 (rank : 833)	θ value	θ > 10 (rank : 1586)
Query Neighborhood Hits	1243	Target Neighborhood Hits	572	Shared Neighborhood Hits	499
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_HUMAN
NC score	0.313683 (rank : 834)	θ value	θ > 10 (rank : 1585)
Query Neighborhood Hits	1243	Target Neighborhood Hits	556	Shared Neighborhood Hits	494
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SRPK2_HUMAN
NC score	0.310833 (rank : 835)	θ value	θ > 10 (rank : 1575)
Query Neighborhood Hits	1243	Target Neighborhood Hits	664	Shared Neighborhood Hits	510
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
NC score	0.309348 (rank : 836)	θ value	θ > 10 (rank : 1576)
Query Neighborhood Hits	1243	Target Neighborhood Hits	765	Shared Neighborhood Hits	522
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK31_HUMAN
NC score	0.284746 (rank : 837)	θ value	θ > 10 (rank : 1587)
Query Neighborhood Hits	1243	Target Neighborhood Hits	570	Shared Neighborhood Hits	349
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

RN5A_MOUSE
NC score	0.282519 (rank : 838)	θ value	θ > 10 (rank : 1521)
Query Neighborhood Hits	1243	Target Neighborhood Hits	899	Shared Neighborhood Hits	579
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

NTKL_MOUSE
NC score	0.277412 (rank : 839)	θ value	θ > 10 (rank : 1468)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	272
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

SLAP2_MOUSE
NC score	0.276373 (rank : 840)	θ value	θ > 10 (rank : 1565)
Query Neighborhood Hits	1243	Target Neighborhood Hits	136	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.268394 (rank : 841)	θ value	θ > 10 (rank : 1564)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP1_HUMAN
NC score	0.264015 (rank : 842)	θ value	θ > 10 (rank : 1562)
Query Neighborhood Hits	1243	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.260401 (rank : 843)	θ value	θ > 10 (rank : 1563)
Query Neighborhood Hits	1243	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

BUB1_HUMAN
NC score	0.247817 (rank : 844)	θ value	θ > 10 (rank : 1264)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	370
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

STK31_MOUSE
NC score	0.233002 (rank : 845)	θ value	θ > 10 (rank : 1588)
Query Neighborhood Hits	1243	Target Neighborhood Hits	474	Shared Neighborhood Hits	287
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

PI3R4_MOUSE
NC score	0.228266 (rank : 846)	θ value	θ > 10 (rank : 1493)
Query Neighborhood Hits	1243	Target Neighborhood Hits	535	Shared Neighborhood Hits	343
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PI3R4_HUMAN
NC score	0.218499 (rank : 847)	θ value	θ > 10 (rank : 1492)
Query Neighborhood Hits	1243	Target Neighborhood Hits	534	Shared Neighborhood Hits	336
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

NTKL_HUMAN
NC score	0.207968 (rank : 848)	θ value	θ > 10 (rank : 1467)
Query Neighborhood Hits	1243	Target Neighborhood Hits	266	Shared Neighborhood Hits	207
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

GRAP_HUMAN
NC score	0.201916 (rank : 849)	θ value	θ > 10 (rank : 1343)
Query Neighborhood Hits	1243	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.201761 (rank : 850)	θ value	θ > 10 (rank : 1344)
Query Neighborhood Hits	1243	Target Neighborhood Hits	309	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VRK3_MOUSE
NC score	0.201430 (rank : 851)	θ value	θ > 10 (rank : 1622)
Query Neighborhood Hits	1243	Target Neighborhood Hits	342	Shared Neighborhood Hits	291
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

K2002_HUMAN
NC score	0.197605 (rank : 852)	θ value	θ > 10 (rank : 1373)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	243
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

GRB2_HUMAN
NC score	0.195279 (rank : 853)	θ value	θ > 10 (rank : 1349)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	63
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.195174 (rank : 854)	θ value	θ > 10 (rank : 1350)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP2_HUMAN
NC score	0.192947 (rank : 855)	θ value	θ > 10 (rank : 1341)
Query Neighborhood Hits	1243	Target Neighborhood Hits	304	Shared Neighborhood Hits	63
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCK2_HUMAN
NC score	0.190934 (rank : 856)	θ value	θ > 10 (rank : 1448)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.190892 (rank : 857)	θ value	θ > 10 (rank : 1447)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP2_MOUSE
NC score	0.189802 (rank : 858)	θ value	θ > 10 (rank : 1342)
Query Neighborhood Hits	1243	Target Neighborhood Hits	297	Shared Neighborhood Hits	61
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

VRK3_HUMAN
NC score	0.189557 (rank : 859)	θ value	0.47712 (rank : 882)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	289
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

SH21B_MOUSE
NC score	0.185900 (rank : 860)	θ value	θ > 10 (rank : 1540)
Query Neighborhood Hits	1243	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21A_MOUSE
NC score	0.168971 (rank : 861)	θ value	θ > 10 (rank : 1538)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
NC score	0.167231 (rank : 862)	θ value	θ > 10 (rank : 1539)
Query Neighborhood Hits	1243	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

K2002_MOUSE
NC score	0.165581 (rank : 863)	θ value	θ > 10 (rank : 1374)
Query Neighborhood Hits	1243	Target Neighborhood Hits	267	Shared Neighborhood Hits	217
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

SH21A_HUMAN
NC score	0.157453 (rank : 864)	θ value	θ > 10 (rank : 1537)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

RASA1_HUMAN
NC score	0.154405 (rank : 865)	θ value	θ > 10 (rank : 1518)
Query Neighborhood Hits	1243	Target Neighborhood Hits	258	Shared Neighborhood Hits	63
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PXK_MOUSE
NC score	0.153252 (rank : 866)	θ value	3.0926 (rank : 1052)
Query Neighborhood Hits	1243	Target Neighborhood Hits	320	Shared Neighborhood Hits	201
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

NEO1_HUMAN
NC score	0.142065 (rank : 867)	θ value	θ > 10 (rank : 1452)
Query Neighborhood Hits	1243	Target Neighborhood Hits	530	Shared Neighborhood Hits	102
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
NC score	0.140677 (rank : 868)	θ value	θ > 10 (rank : 1453)
Query Neighborhood Hits	1243	Target Neighborhood Hits	523	Shared Neighborhood Hits	107
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

DAPP1_HUMAN
NC score	0.138861 (rank : 869)	θ value	θ > 10 (rank : 1310)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCC_MOUSE
NC score	0.137070 (rank : 870)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	243
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

CRKL_MOUSE
NC score	0.136597 (rank : 871)	θ value	θ > 10 (rank : 1299)
Query Neighborhood Hits	1243	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DAPP1_MOUSE
NC score	0.135213 (rank : 872)	θ value	θ > 10 (rank : 1311)
Query Neighborhood Hits	1243	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CRKL_HUMAN
NC score	0.134254 (rank : 873)	θ value	θ > 10 (rank : 1298)
Query Neighborhood Hits	1243	Target Neighborhood Hits	313	Shared Neighborhood Hits	62
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DCC_HUMAN
NC score	0.132853 (rank : 874)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	1243	Target Neighborhood Hits	583	Shared Neighborhood Hits	124
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

HSH2D_HUMAN
NC score	0.132584 (rank : 875)	θ value	θ > 10 (rank : 1360)
Query Neighborhood Hits	1243	Target Neighborhood Hits	159	Shared Neighborhood Hits	46
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

DSCL1_HUMAN
NC score	0.132203 (rank : 876)	θ value	θ > 10 (rank : 1320)
Query Neighborhood Hits	1243	Target Neighborhood Hits	589	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

VAV3_MOUSE
NC score	0.131983 (rank : 877)	θ value	θ > 10 (rank : 1613)
Query Neighborhood Hits	1243	Target Neighborhood Hits	404	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.131693 (rank : 878)	θ value	θ > 10 (rank : 1612)
Query Neighborhood Hits	1243	Target Neighborhood Hits	398	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FGRL1_MOUSE
NC score	0.130330 (rank : 879)	θ value	θ > 10 (rank : 1332)
Query Neighborhood Hits	1243	Target Neighborhood Hits	325	Shared Neighborhood Hits	48
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

SHE_MOUSE
NC score	0.130234 (rank : 880)	θ value	θ > 10 (rank : 1559)
Query Neighborhood Hits	1243	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_HUMAN
NC score	0.129836 (rank : 881)	θ value	θ > 10 (rank : 1558)
Query Neighborhood Hits	1243	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SDK1_HUMAN
NC score	0.129060 (rank : 882)	θ value	θ > 10 (rank : 1533)
Query Neighborhood Hits	1243	Target Neighborhood Hits	511	Shared Neighborhood Hits	105
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

GRB14_MOUSE
NC score	0.127769 (rank : 883)	θ value	θ > 10 (rank : 1348)
Query Neighborhood Hits	1243	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

FGRL1_HUMAN
NC score	0.126605 (rank : 884)	θ value	θ > 10 (rank : 1331)
Query Neighborhood Hits	1243	Target Neighborhood Hits	335	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

STAC3_HUMAN
NC score	0.126465 (rank : 885)	θ value	θ > 10 (rank : 1577)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	75
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SDK2_HUMAN
NC score	0.125903 (rank : 886)	θ value	θ > 10 (rank : 1535)
Query Neighborhood Hits	1243	Target Neighborhood Hits	495	Shared Neighborhood Hits	94
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK1_MOUSE
NC score	0.125618 (rank : 887)	θ value	θ > 10 (rank : 1534)
Query Neighborhood Hits	1243	Target Neighborhood Hits	495	Shared Neighborhood Hits	100
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

STAC3_MOUSE
NC score	0.125530 (rank : 888)	θ value	θ > 10 (rank : 1578)
Query Neighborhood Hits	1243	Target Neighborhood Hits	232	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DSCAM_HUMAN
NC score	0.125134 (rank : 889)	θ value	θ > 10 (rank : 1319)
Query Neighborhood Hits	1243	Target Neighborhood Hits	524	Shared Neighborhood Hits	89
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

PRPK_MOUSE
NC score	0.124587 (rank : 890)	θ value	θ > 10 (rank : 1503)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	128
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PLCG1_MOUSE
NC score	0.124222 (rank : 891)	θ value	θ > 10 (rank : 1495)
Query Neighborhood Hits	1243	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.124169 (rank : 892)	θ value	θ > 10 (rank : 1494)
Query Neighborhood Hits	1243	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.123405 (rank : 893)	θ value	θ > 10 (rank : 1496)
Query Neighborhood Hits	1243	Target Neighborhood Hits	280	Shared Neighborhood Hits	54
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV_HUMAN
NC score	0.122594 (rank : 894)	θ value	θ > 10 (rank : 1614)
Query Neighborhood Hits	1243	Target Neighborhood Hits	452	Shared Neighborhood Hits	96
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

L1CAM_HUMAN
NC score	0.122342 (rank : 895)	θ value	θ > 10 (rank : 1385)
Query Neighborhood Hits	1243	Target Neighborhood Hits	457	Shared Neighborhood Hits	94
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

VAV2_HUMAN
NC score	0.122287 (rank : 896)	θ value	θ > 10 (rank : 1610)
Query Neighborhood Hits	1243	Target Neighborhood Hits	453	Shared Neighborhood Hits	101
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SDK2_MOUSE
NC score	0.122057 (rank : 897)	θ value	θ > 10 (rank : 1536)
Query Neighborhood Hits	1243	Target Neighborhood Hits	480	Shared Neighborhood Hits	92
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

NCAM2_MOUSE
NC score	0.122040 (rank : 898)	θ value	θ > 10 (rank : 1444)
Query Neighborhood Hits	1243	Target Neighborhood Hits	472	Shared Neighborhood Hits	84
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

P55G_HUMAN
NC score	0.121354 (rank : 899)	θ value	θ > 10 (rank : 1475)
Query Neighborhood Hits	1243	Target Neighborhood Hits	451	Shared Neighborhood Hits	64
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_MOUSE
NC score	0.120805 (rank : 900)	θ value	θ > 10 (rank : 1480)
Query Neighborhood Hits	1243	Target Neighborhood Hits	519	Shared Neighborhood Hits	80
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

GRB14_HUMAN
NC score	0.119824 (rank : 901)	θ value	θ > 10 (rank : 1347)
Query Neighborhood Hits	1243	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ROBO1_MOUSE
NC score	0.119706 (rank : 902)	θ value	θ > 10 (rank : 1523)
Query Neighborhood Hits	1243	Target Neighborhood Hits	559	Shared Neighborhood Hits	108
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

P55G_MOUSE
NC score	0.119368 (rank : 903)	θ value	θ > 10 (rank : 1476)
Query Neighborhood Hits	1243	Target Neighborhood Hits	401	Shared Neighborhood Hits	64
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PGFRL_MOUSE
NC score	0.119177 (rank : 904)	θ value	θ > 10 (rank : 1491)
Query Neighborhood Hits	1243	Target Neighborhood Hits	106	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

NRCAM_HUMAN
NC score	0.119056 (rank : 905)	θ value	θ > 10 (rank : 1463)
Query Neighborhood Hits	1243	Target Neighborhood Hits	439	Shared Neighborhood Hits	89
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ROBO1_HUMAN
NC score	0.118646 (rank : 906)	θ value	θ > 10 (rank : 1522)
Query Neighborhood Hits	1243	Target Neighborhood Hits	529	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

STAC_MOUSE
NC score	0.118313 (rank : 907)	θ value	θ > 10 (rank : 1580)
Query Neighborhood Hits	1243	Target Neighborhood Hits	268	Shared Neighborhood Hits	83
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PRPK_HUMAN
NC score	0.117897 (rank : 908)	θ value	θ > 10 (rank : 1502)
Query Neighborhood Hits	1243	Target Neighborhood Hits	131	Shared Neighborhood Hits	124
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

VAV2_MOUSE
NC score	0.117813 (rank : 909)	θ value	θ > 10 (rank : 1611)
Query Neighborhood Hits	1243	Target Neighborhood Hits	456	Shared Neighborhood Hits	108
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

NCAM2_HUMAN
NC score	0.117381 (rank : 910)	θ value	θ > 10 (rank : 1443)
Query Neighborhood Hits	1243	Target Neighborhood Hits	441	Shared Neighborhood Hits	82
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NRCAM_MOUSE
NC score	0.116795 (rank : 911)	θ value	θ > 10 (rank : 1464)
Query Neighborhood Hits	1243	Target Neighborhood Hits	432	Shared Neighborhood Hits	89
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

P85B_HUMAN
NC score	0.116747 (rank : 912)	θ value	θ > 10 (rank : 1479)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	91
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ROBO2_MOUSE
NC score	0.116709 (rank : 913)	θ value	θ > 10 (rank : 1525)
Query Neighborhood Hits	1243	Target Neighborhood Hits	504	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

L1CAM_MOUSE
NC score	0.116568 (rank : 914)	θ value	θ > 10 (rank : 1386)
Query Neighborhood Hits	1243	Target Neighborhood Hits	457	Shared Neighborhood Hits	92
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NFASC_HUMAN
NC score	0.116374 (rank : 915)	θ value	θ > 10 (rank : 1454)
Query Neighborhood Hits	1243	Target Neighborhood Hits	497	Shared Neighborhood Hits	101
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

ROBO2_HUMAN
NC score	0.115854 (rank : 916)	θ value	θ > 10 (rank : 1524)
Query Neighborhood Hits	1243	Target Neighborhood Hits	479	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
NC score	0.115752 (rank : 917)	θ value	0.365318 (rank : 858)
Query Neighborhood Hits	1243	Target Neighborhood Hits	570	Shared Neighborhood Hits	122
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

CRK_HUMAN
NC score	0.115051 (rank : 918)	θ value	θ > 10 (rank : 1300)
Query Neighborhood Hits	1243	Target Neighborhood Hits	308	Shared Neighborhood Hits	60
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PGFRL_HUMAN
NC score	0.114644 (rank : 919)	θ value	θ > 10 (rank : 1490)
Query Neighborhood Hits	1243	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

RN5A_HUMAN
NC score	0.112700 (rank : 920)	θ value	θ > 10 (rank : 1520)
Query Neighborhood Hits	1243	Target Neighborhood Hits	608	Shared Neighborhood Hits	312
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

VAV_MOUSE
NC score	0.112583 (rank : 921)	θ value	θ > 10 (rank : 1615)
Query Neighborhood Hits	1243	Target Neighborhood Hits	430	Shared Neighborhood Hits	92
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CRK_MOUSE
NC score	0.112481 (rank : 922)	θ value	θ > 10 (rank : 1301)
Query Neighborhood Hits	1243	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

APS_HUMAN
NC score	0.111916 (rank : 923)	θ value	θ > 10 (rank : 1252)
Query Neighborhood Hits	1243	Target Neighborhood Hits	162	Shared Neighborhood Hits	53
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRB7_MOUSE
NC score	0.111372 (rank : 924)	θ value	θ > 10 (rank : 1352)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

MYOM1_MOUSE
NC score	0.111329 (rank : 925)	θ value	θ > 10 (rank : 1428)
Query Neighborhood Hits	1243	Target Neighborhood Hits	415	Shared Neighborhood Hits	88
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

ROBO3_MOUSE
NC score	0.110364 (rank : 926)	θ value	θ > 10 (rank : 1526)
Query Neighborhood Hits	1243	Target Neighborhood Hits	524	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

CNTN5_HUMAN
NC score	0.109813 (rank : 927)	θ value	θ > 10 (rank : 1293)
Query Neighborhood Hits	1243	Target Neighborhood Hits	446	Shared Neighborhood Hits	86
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

NCA11_HUMAN
NC score	0.109712 (rank : 928)	θ value	θ > 10 (rank : 1439)
Query Neighborhood Hits	1243	Target Neighborhood Hits	443	Shared Neighborhood Hits	72
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

PTPRD_HUMAN
NC score	0.109146 (rank : 929)	θ value	θ > 10 (rank : 1508)
Query Neighborhood Hits	1243	Target Neighborhood Hits	485	Shared Neighborhood Hits	94
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
NC score	0.109114 (rank : 930)	θ value	θ > 10 (rank : 1509)
Query Neighborhood Hits	1243	Target Neighborhood Hits	491	Shared Neighborhood Hits	92
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

SHB_MOUSE
NC score	0.109037 (rank : 931)	θ value	θ > 10 (rank : 1549)
Query Neighborhood Hits	1243	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

STAC_HUMAN
NC score	0.108773 (rank : 932)	θ value	θ > 10 (rank : 1579)
Query Neighborhood Hits	1243	Target Neighborhood Hits	276	Shared Neighborhood Hits	84
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MYOM1_HUMAN
NC score	0.108440 (rank : 933)	θ value	θ > 10 (rank : 1427)
Query Neighborhood Hits	1243	Target Neighborhood Hits	405	Shared Neighborhood Hits	86
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

PTPRF_HUMAN
NC score	0.107517 (rank : 934)	θ value	θ > 10 (rank : 1510)
Query Neighborhood Hits	1243	Target Neighborhood Hits	489	Shared Neighborhood Hits	95
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

NCA12_HUMAN
NC score	0.107397 (rank : 935)	θ value	θ > 10 (rank : 1441)
Query Neighborhood Hits	1243	Target Neighborhood Hits	437	Shared Neighborhood Hits	73
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

PTPRS_HUMAN
NC score	0.107304 (rank : 936)	θ value	θ > 10 (rank : 1511)
Query Neighborhood Hits	1243	Target Neighborhood Hits	472	Shared Neighborhood Hits	94
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

CNTN2_HUMAN
NC score	0.106467 (rank : 937)	θ value	θ > 10 (rank : 1287)
Query Neighborhood Hits	1243	Target Neighborhood Hits	440	Shared Neighborhood Hits	88
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

BOC_HUMAN
NC score	0.106354 (rank : 938)	θ value	θ > 10 (rank : 1261)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCA11_MOUSE
NC score	0.106278 (rank : 939)	θ value	θ > 10 (rank : 1440)
Query Neighborhood Hits	1243	Target Neighborhood Hits	661	Shared Neighborhood Hits	127
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NFASC_MOUSE
NC score	0.106224 (rank : 940)	θ value	θ > 10 (rank : 1455)
Query Neighborhood Hits	1243	Target Neighborhood Hits	475	Shared Neighborhood Hits	95
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

CNTN2_MOUSE
NC score	0.106042 (rank : 941)	θ value	θ > 10 (rank : 1288)
Query Neighborhood Hits	1243	Target Neighborhood Hits	450	Shared Neighborhood Hits	86
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

SHC1_HUMAN
NC score	0.106030 (rank : 942)	θ value	θ > 10 (rank : 1550)
Query Neighborhood Hits	1243	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRB7_HUMAN
NC score	0.105968 (rank : 943)	θ value	θ > 10 (rank : 1351)
Query Neighborhood Hits	1243	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PXK_HUMAN
NC score	0.105961 (rank : 944)	θ value	θ > 10 (rank : 1515)
Query Neighborhood Hits	1243	Target Neighborhood Hits	216	Shared Neighborhood Hits	134
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

LNK_HUMAN
NC score	0.105856 (rank : 945)	θ value	θ > 10 (rank : 1389)
Query Neighborhood Hits	1243	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHC2_HUMAN
NC score	0.105695 (rank : 946)	θ value	θ > 10 (rank : 1552)
Query Neighborhood Hits	1243	Target Neighborhood Hits	170	Shared Neighborhood Hits	57
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC1_MOUSE
NC score	0.105293 (rank : 947)	θ value	θ > 10 (rank : 1551)
Query Neighborhood Hits	1243	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

MYOM2_HUMAN
NC score	0.104986 (rank : 948)	θ value	θ > 10 (rank : 1429)
Query Neighborhood Hits	1243	Target Neighborhood Hits	341	Shared Neighborhood Hits	74
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

SHB_HUMAN
NC score	0.104082 (rank : 949)	θ value	θ > 10 (rank : 1548)
Query Neighborhood Hits	1243	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PUNC_HUMAN
NC score	0.103703 (rank : 950)	θ value	θ > 10 (rank : 1513)
Query Neighborhood Hits	1243	Target Neighborhood Hits	449	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

CDON_HUMAN
NC score	0.103393 (rank : 951)	θ value	θ > 10 (rank : 1272)
Query Neighborhood Hits	1243	Target Neighborhood Hits	412	Shared Neighborhood Hits	68
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

P85A_MOUSE
NC score	0.102561 (rank : 952)	θ value	θ > 10 (rank : 1478)
Query Neighborhood Hits	1243	Target Neighborhood Hits	435	Shared Neighborhood Hits	65
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHD_MOUSE
NC score	0.102450 (rank : 953)	θ value	θ > 10 (rank : 1557)
Query Neighborhood Hits	1243	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

CNTN3_HUMAN
NC score	0.102413 (rank : 954)	θ value	θ > 10 (rank : 1289)
Query Neighborhood Hits	1243	Target Neighborhood Hits	455	Shared Neighborhood Hits	83
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

PUNC_MOUSE
NC score	0.101460 (rank : 955)	θ value	θ > 10 (rank : 1514)
Query Neighborhood Hits	1243	Target Neighborhood Hits	501	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

SPN90_HUMAN
NC score	0.101253 (rank : 956)	θ value	θ > 10 (rank : 1570)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

P85A_HUMAN
NC score	0.101205 (rank : 957)	θ value	θ > 10 (rank : 1477)
Query Neighborhood Hits	1243	Target Neighborhood Hits	479	Shared Neighborhood Hits	67
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

NPHP1_MOUSE
NC score	0.100927 (rank : 958)	θ value	θ > 10 (rank : 1459)
Query Neighborhood Hits	1243	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CDON_MOUSE
NC score	0.099935 (rank : 959)	θ value	θ > 10 (rank : 1273)
Query Neighborhood Hits	1243	Target Neighborhood Hits	410	Shared Neighborhood Hits	67
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CNTN5_MOUSE
NC score	0.099790 (rank : 960)	θ value	θ > 10 (rank : 1294)
Query Neighborhood Hits	1243	Target Neighborhood Hits	434	Shared Neighborhood Hits	83
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

BOC_MOUSE
NC score	0.099609 (rank : 961)	θ value	θ > 10 (rank : 1262)
Query Neighborhood Hits	1243	Target Neighborhood Hits	433	Shared Neighborhood Hits	82
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

SH24A_HUMAN
NC score	0.099590 (rank : 962)	θ value	θ > 10 (rank : 1544)
Query Neighborhood Hits	1243	Target Neighborhood Hits	455	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

NPHP1_HUMAN
NC score	0.099376 (rank : 963)	θ value	θ > 10 (rank : 1458)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

MYOTI_HUMAN
NC score	0.098818 (rank : 964)	θ value	θ > 10 (rank : 1430)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

SHD_HUMAN
NC score	0.098408 (rank : 965)	θ value	θ > 10 (rank : 1556)
Query Neighborhood Hits	1243	Target Neighborhood Hits	204	Shared Neighborhood Hits	60
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

MYPN_HUMAN
NC score	0.098052 (rank : 966)	θ value	θ > 10 (rank : 1437)
Query Neighborhood Hits	1243	Target Neighborhood Hits	418	Shared Neighborhood Hits	75
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NCA12_MOUSE
NC score	0.097922 (rank : 967)	θ value	θ > 10 (rank : 1442)
Query Neighborhood Hits	1243	Target Neighborhood Hits	399	Shared Neighborhood Hits	63
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

MYPN_MOUSE
NC score	0.097780 (rank : 968)	θ value	θ > 10 (rank : 1438)
Query Neighborhood Hits	1243	Target Neighborhood Hits	421	Shared Neighborhood Hits	74
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

IASPP_MOUSE
NC score	0.097671 (rank : 969)	θ value	0.163984 (rank : 808)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1024	Shared Neighborhood Hits	284
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SHC2_MOUSE
NC score	0.097527 (rank : 970)	θ value	θ > 10 (rank : 1553)
Query Neighborhood Hits	1243	Target Neighborhood Hits	144	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_MOUSE
NC score	0.097251 (rank : 971)	θ value	θ > 10 (rank : 1555)
Query Neighborhood Hits	1243	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

LSAMP_HUMAN
NC score	0.097126 (rank : 972)	θ value	θ > 10 (rank : 1401)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	49
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYPC3_MOUSE
NC score	0.096282 (rank : 973)	θ value	θ > 10 (rank : 1436)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	72
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

LSAMP_MOUSE
NC score	0.096023 (rank : 974)	θ value	θ > 10 (rank : 1402)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

ES8L3_HUMAN
NC score	0.095632 (rank : 975)	θ value	θ > 10 (rank : 1329)
Query Neighborhood Hits	1243	Target Neighborhood Hits	206	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CNTN3_MOUSE
NC score	0.095369 (rank : 976)	θ value	θ > 10 (rank : 1290)
Query Neighborhood Hits	1243	Target Neighborhood Hits	447	Shared Neighborhood Hits	82
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

LNK_MOUSE
NC score	0.095286 (rank : 977)	θ value	θ > 10 (rank : 1390)
Query Neighborhood Hits	1243	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

CNTN4_HUMAN
NC score	0.094963 (rank : 978)	θ value	θ > 10 (rank : 1291)
Query Neighborhood Hits	1243	Target Neighborhood Hits	449	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_MOUSE
NC score	0.094435 (rank : 979)	θ value	θ > 10 (rank : 1292)
Query Neighborhood Hits	1243	Target Neighborhood Hits	445	Shared Neighborhood Hits	77
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

SPN90_MOUSE
NC score	0.093814 (rank : 980)	θ value	θ > 10 (rank : 1571)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

MYPC3_HUMAN
NC score	0.093440 (rank : 981)	θ value	θ > 10 (rank : 1435)
Query Neighborhood Hits	1243	Target Neighborhood Hits	318	Shared Neighborhood Hits	74
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

CHL1_HUMAN
NC score	0.092864 (rank : 982)	θ value	θ > 10 (rank : 1279)
Query Neighborhood Hits	1243	Target Neighborhood Hits	413	Shared Neighborhood Hits	80
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

MYOTI_MOUSE
NC score	0.092541 (rank : 983)	θ value	θ > 10 (rank : 1431)
Query Neighborhood Hits	1243	Target Neighborhood Hits	297	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

CNTN1_MOUSE
NC score	0.091796 (rank : 984)	θ value	θ > 10 (rank : 1286)
Query Neighborhood Hits	1243	Target Neighborhood Hits	422	Shared Neighborhood Hits	77
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

LCP2_HUMAN
NC score	0.090726 (rank : 985)	θ value	θ > 10 (rank : 1387)
Query Neighborhood Hits	1243	Target Neighborhood Hits	531	Shared Neighborhood Hits	186
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CNTN1_HUMAN
NC score	0.090572 (rank : 986)	θ value	θ > 10 (rank : 1285)
Query Neighborhood Hits	1243	Target Neighborhood Hits	431	Shared Neighborhood Hits	77
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

GRB10_MOUSE
NC score	0.090241 (rank : 987)	θ value	θ > 10 (rank : 1346)
Query Neighborhood Hits	1243	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

CHL1_MOUSE
NC score	0.090089 (rank : 988)	θ value	θ > 10 (rank : 1280)
Query Neighborhood Hits	1243	Target Neighborhood Hits	402	Shared Neighborhood Hits	76
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

SHC3_HUMAN
NC score	0.089827 (rank : 989)	θ value	θ > 10 (rank : 1554)
Query Neighborhood Hits	1243	Target Neighborhood Hits	155	Shared Neighborhood Hits	44
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

TMIGD_HUMAN
NC score	0.089807 (rank : 990)	θ value	θ > 10 (rank : 1600)
Query Neighborhood Hits	1243	Target Neighborhood Hits	240	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

FNDC3_MOUSE
NC score	0.089708 (rank : 991)	θ value	θ > 10 (rank : 1336)
Query Neighborhood Hits	1243	Target Neighborhood Hits	207	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

OGFR_HUMAN
NC score	0.089374 (rank : 992)	θ value	0.0148317 (rank : 714)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1582	Shared Neighborhood Hits	402
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

GRB10_HUMAN
NC score	0.088820 (rank : 993)	θ value	θ > 10 (rank : 1345)
Query Neighborhood Hits	1243	Target Neighborhood Hits	147	Shared Neighborhood Hits	53
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

CNTN6_HUMAN
NC score	0.088785 (rank : 994)	θ value	θ > 10 (rank : 1295)
Query Neighborhood Hits	1243	Target Neighborhood Hits	422	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN6_MOUSE
NC score	0.088566 (rank : 995)	θ value	θ > 10 (rank : 1296)
Query Neighborhood Hits	1243	Target Neighborhood Hits	429	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

SOCS7_MOUSE
NC score	0.088089 (rank : 996)	θ value	0.0736092 (rank : 770)
Query Neighborhood Hits	1243	Target Neighborhood Hits	154	Shared Neighborhood Hits	45
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

NTRI_MOUSE
NC score	0.087935 (rank : 997)	θ value	θ > 10 (rank : 1470)
Query Neighborhood Hits	1243	Target Neighborhood Hits	342	Shared Neighborhood Hits	50
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

FNDC3_HUMAN
NC score	0.087855 (rank : 998)	θ value	θ > 10 (rank : 1335)
Query Neighborhood Hits	1243	Target Neighborhood Hits	196	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

NTRI_HUMAN
NC score	0.086421 (rank : 999)	θ value	θ > 10 (rank : 1469)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NEGR1_HUMAN
NC score	0.086403 (rank : 1000)	θ value	θ > 10 (rank : 1450)
Query Neighborhood Hits	1243	Target Neighborhood Hits	346	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

CIP4_HUMAN
NC score	0.086074 (rank : 1001)	θ value	θ > 10 (rank : 1282)
Query Neighborhood Hits	1243	Target Neighborhood Hits	374	Shared Neighborhood Hits	49
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

NEGR1_MOUSE
NC score	0.084625 (rank : 1002)	θ value	θ > 10 (rank : 1451)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

PTN11_MOUSE
NC score	0.084264 (rank : 1003)	θ value	θ > 10 (rank : 1505)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.084197 (rank : 1004)	θ value	θ > 10 (rank : 1504)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

OBSL1_HUMAN
NC score	0.084184 (rank : 1005)	θ value	θ > 10 (rank : 1471)
Query Neighborhood Hits	1243	Target Neighborhood Hits	354	Shared Neighborhood Hits	53
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

APS_MOUSE
NC score	0.083536 (rank : 1006)	θ value	θ > 10 (rank : 1253)
Query Neighborhood Hits	1243	Target Neighborhood Hits	134	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

TMIGD_MOUSE
NC score	0.082109 (rank : 1007)	θ value	θ > 10 (rank : 1601)
Query Neighborhood Hits	1243	Target Neighborhood Hits	234	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

FSTL5_HUMAN
NC score	0.081759 (rank : 1008)	θ value	θ > 10 (rank : 1339)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

MUC1_HUMAN
NC score	0.081743 (rank : 1009)	θ value	1.09739e-05 (rank : 500)
Query Neighborhood Hits	1243	Target Neighborhood Hits	975	Shared Neighborhood Hits	297
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MFA3L_HUMAN
NC score	0.081497 (rank : 1010)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	1243	Target Neighborhood Hits	230	Shared Neighborhood Hits	38
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

MAMC1_HUMAN
NC score	0.081208 (rank : 1011)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	1243	Target Neighborhood Hits	357	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

TARSH_HUMAN
NC score	0.081206 (rank : 1012)	θ value	θ > 10 (rank : 1591)
Query Neighborhood Hits	1243	Target Neighborhood Hits	768	Shared Neighborhood Hits	227
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

OPCM_HUMAN
NC score	0.081142 (rank : 1013)	θ value	θ > 10 (rank : 1472)
Query Neighborhood Hits	1243	Target Neighborhood Hits	332	Shared Neighborhood Hits	49
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

OSTF1_HUMAN
NC score	0.080816 (rank : 1014)	θ value	θ > 10 (rank : 1473)
Query Neighborhood Hits	1243	Target Neighborhood Hits	466	Shared Neighborhood Hits	60
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ROBO4_MOUSE
NC score	0.080416 (rank : 1015)	θ value	θ > 10 (rank : 1528)
Query Neighborhood Hits	1243	Target Neighborhood Hits	358	Shared Neighborhood Hits	68
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MAMC1_MOUSE
NC score	0.080142 (rank : 1016)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	1243	Target Neighborhood Hits	357	Shared Neighborhood Hits	50
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

CHIN_MOUSE
NC score	0.079274 (rank : 1017)	θ value	θ > 10 (rank : 1277)
Query Neighborhood Hits	1243	Target Neighborhood Hits	229	Shared Neighborhood Hits	66
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

MAG_HUMAN
NC score	0.078996 (rank : 1018)	θ value	θ > 10 (rank : 1407)
Query Neighborhood Hits	1243	Target Neighborhood Hits	278	Shared Neighborhood Hits	43
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

FSTL4_HUMAN
NC score	0.078424 (rank : 1019)	θ value	θ > 10 (rank : 1337)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	47
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

CHIO_HUMAN
NC score	0.078397 (rank : 1020)	θ value	θ > 10 (rank : 1278)
Query Neighborhood Hits	1243	Target Neighborhood Hits	220	Shared Neighborhood Hits	64
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

ES8L3_MOUSE
NC score	0.078038 (rank : 1021)	θ value	θ > 10 (rank : 1330)
Query Neighborhood Hits	1243	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FSTL5_MOUSE
NC score	0.077906 (rank : 1022)	θ value	θ > 10 (rank : 1340)
Query Neighborhood Hits	1243	Target Neighborhood Hits	355	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

CHIN_HUMAN
NC score	0.077781 (rank : 1023)	θ value	θ > 10 (rank : 1276)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

DGKD_HUMAN
NC score	0.077772 (rank : 1024)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	1243	Target Neighborhood Hits	231	Shared Neighborhood Hits	76
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

IASPP_HUMAN
NC score	0.077345 (rank : 1025)	θ value	0.813845 (rank : 920)
Query Neighborhood Hits	1243	Target Neighborhood Hits	688	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MAG_MOUSE
NC score	0.077022 (rank : 1026)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	43
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

SH2D3_MOUSE
NC score	0.076693 (rank : 1027)	θ value	θ > 10 (rank : 1547)
Query Neighborhood Hits	1243	Target Neighborhood Hits	174	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

HSH2D_MOUSE
NC score	0.075582 (rank : 1028)	θ value	θ > 10 (rank : 1361)
Query Neighborhood Hits	1243	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SH2D3_HUMAN
NC score	0.075025 (rank : 1029)	θ value	θ > 10 (rank : 1546)
Query Neighborhood Hits	1243	Target Neighborhood Hits	188	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

STAM2_MOUSE
NC score	0.074440 (rank : 1030)	θ value	θ > 10 (rank : 1584)
Query Neighborhood Hits	1243	Target Neighborhood Hits	285	Shared Neighborhood Hits	47
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

FSTL4_MOUSE
NC score	0.074253 (rank : 1031)	θ value	θ > 10 (rank : 1338)
Query Neighborhood Hits	1243	Target Neighborhood Hits	333	Shared Neighborhood Hits	42
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

OSTF1_MOUSE
NC score	0.073860 (rank : 1032)	θ value	θ > 10 (rank : 1474)
Query Neighborhood Hits	1243	Target Neighborhood Hits	467	Shared Neighborhood Hits	60
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ROBO4_HUMAN
NC score	0.073742 (rank : 1033)	θ value	θ > 10 (rank : 1527)
Query Neighborhood Hits	1243	Target Neighborhood Hits	364	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

MDGA1_HUMAN
NC score	0.073610 (rank : 1034)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	1243	Target Neighborhood Hits	358	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

HMCN1_HUMAN
NC score	0.072957 (rank : 1035)	θ value	θ > 10 (rank : 1359)
Query Neighborhood Hits	1243	Target Neighborhood Hits	983	Shared Neighborhood Hits	75
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

MYPC2_HUMAN
NC score	0.072769 (rank : 1036)	θ value	θ > 10 (rank : 1433)
Query Neighborhood Hits	1243	Target Neighborhood Hits	316	Shared Neighborhood Hits	70
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

ES8L2_MOUSE
NC score	0.072723 (rank : 1037)	θ value	θ > 10 (rank : 1328)
Query Neighborhood Hits	1243	Target Neighborhood Hits	169	Shared Neighborhood Hits	43
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_HUMAN
NC score	0.072014 (rank : 1038)	θ value	θ > 10 (rank : 1327)
Query Neighborhood Hits	1243	Target Neighborhood Hits	193	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SON_HUMAN
NC score	0.071989 (rank : 1039)	θ value	0.0961366 (rank : 793)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1568	Shared Neighborhood Hits	385
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

JAM2_HUMAN
NC score	0.071897 (rank : 1040)	θ value	θ > 10 (rank : 1371)
Query Neighborhood Hits	1243	Target Neighborhood Hits	304	Shared Neighborhood Hits	42
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

MYBPH_MOUSE
NC score	0.071280 (rank : 1041)	θ value	θ > 10 (rank : 1426)
Query Neighborhood Hits	1243	Target Neighborhood Hits	290	Shared Neighborhood Hits	74
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

BLNK_MOUSE
NC score	0.070978 (rank : 1042)	θ value	8.99809 (rank : 1193)
Query Neighborhood Hits	1243	Target Neighborhood Hits	296	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BSN_MOUSE
NC score	0.070809 (rank : 1043)	θ value	0.365318 (rank : 849)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2057	Shared Neighborhood Hits	413
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

SH24A_MOUSE
NC score	0.070725 (rank : 1044)	θ value	θ > 10 (rank : 1545)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

NPHN_HUMAN
NC score	0.070355 (rank : 1045)	θ value	θ > 10 (rank : 1456)
Query Neighborhood Hits	1243	Target Neighborhood Hits	362	Shared Neighborhood Hits	59
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

PRRT3_HUMAN
NC score	0.070302 (rank : 1046)	θ value	4.03905 (rank : 1080)
Query Neighborhood Hits	1243	Target Neighborhood Hits	998	Shared Neighborhood Hits	323
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

STAM2_HUMAN
NC score	0.070156 (rank : 1047)	θ value	θ > 10 (rank : 1583)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	51
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH22A_MOUSE
NC score	0.070105 (rank : 1048)	θ value	θ > 10 (rank : 1542)
Query Neighborhood Hits	1243	Target Neighborhood Hits	179	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

GRP3_HUMAN
NC score	0.070042 (rank : 1049)	θ value	θ > 10 (rank : 1353)
Query Neighborhood Hits	1243	Target Neighborhood Hits	131	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PGBM_MOUSE
NC score	0.069567 (rank : 1050)	θ value	θ > 10 (rank : 1489)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1073	Shared Neighborhood Hits	102
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

MALT1_HUMAN
NC score	0.069145 (rank : 1051)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	1243	Target Neighborhood Hits	236	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

ANM2_HUMAN
NC score	0.069110 (rank : 1052)	θ value	θ > 10 (rank : 1250)
Query Neighborhood Hits	1243	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

STAM1_MOUSE
NC score	0.068868 (rank : 1053)	θ value	θ > 10 (rank : 1582)
Query Neighborhood Hits	1243	Target Neighborhood Hits	273	Shared Neighborhood Hits	50
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PGBM_HUMAN
NC score	0.068607 (rank : 1054)	θ value	θ > 10 (rank : 1488)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1113	Shared Neighborhood Hits	112
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

LCP2_MOUSE
NC score	0.068499 (rank : 1055)	θ value	θ > 10 (rank : 1388)
Query Neighborhood Hits	1243	Target Neighborhood Hits	177	Shared Neighborhood Hits	61
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

DGKH_HUMAN
NC score	0.068041 (rank : 1056)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	1243	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

STAM1_HUMAN
NC score	0.067941 (rank : 1057)	θ value	θ > 10 (rank : 1581)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	53
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

MYPC2_MOUSE
NC score	0.067175 (rank : 1058)	θ value	θ > 10 (rank : 1434)
Query Neighborhood Hits	1243	Target Neighborhood Hits	297	Shared Neighborhood Hits	63
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

PPIP1_HUMAN
NC score	0.067137 (rank : 1059)	θ value	θ > 10 (rank : 1498)
Query Neighborhood Hits	1243	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PTN6_MOUSE
NC score	0.067053 (rank : 1060)	θ value	θ > 10 (rank : 1507)
Query Neighborhood Hits	1243	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RGS3_MOUSE
NC score	0.066873 (rank : 1061)	θ value	0.0961366 (rank : 791)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1621	Shared Neighborhood Hits	392
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

NRG2_HUMAN
NC score	0.066548 (rank : 1062)	θ value	θ > 10 (rank : 1465)
Query Neighborhood Hits	1243	Target Neighborhood Hits	419	Shared Neighborhood Hits	58
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

TENS4_MOUSE
NC score	0.066424 (rank : 1063)	θ value	θ > 10 (rank : 1593)
Query Neighborhood Hits	1243	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

CSKI1_MOUSE
NC score	0.066384 (rank : 1064)	θ value	θ > 10 (rank : 1307)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1031	Shared Neighborhood Hits	270
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.066088 (rank : 1065)	θ value	θ > 10 (rank : 1306)
Query Neighborhood Hits	1243	Target Neighborhood Hits	997	Shared Neighborhood Hits	262
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MYBPH_HUMAN
NC score	0.065671 (rank : 1066)	θ value	θ > 10 (rank : 1425)
Query Neighborhood Hits	1243	Target Neighborhood Hits	256	Shared Neighborhood Hits	74
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

SH23A_HUMAN
NC score	0.065134 (rank : 1067)	θ value	θ > 10 (rank : 1543)
Query Neighborhood Hits	1243	Target Neighborhood Hits	149	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

NPHN_MOUSE
NC score	0.064780 (rank : 1068)	θ value	θ > 10 (rank : 1457)
Query Neighborhood Hits	1243	Target Neighborhood Hits	370	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

ANM2_MOUSE
NC score	0.064467 (rank : 1069)	θ value	θ > 10 (rank : 1251)
Query Neighborhood Hits	1243	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MYPC1_HUMAN
NC score	0.064439 (rank : 1070)	θ value	θ > 10 (rank : 1432)
Query Neighborhood Hits	1243	Target Neighborhood Hits	303	Shared Neighborhood Hits	55
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

LRIG1_HUMAN
NC score	0.064307 (rank : 1071)	θ value	θ > 10 (rank : 1391)
Query Neighborhood Hits	1243	Target Neighborhood Hits	654	Shared Neighborhood Hits	68
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

NACAM_MOUSE
NC score	0.064215 (rank : 1072)	θ value	0.0252991 (rank : 730)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1866	Shared Neighborhood Hits	381
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ES8L1_HUMAN
NC score	0.063889 (rank : 1073)	θ value	θ > 10 (rank : 1325)
Query Neighborhood Hits	1243	Target Neighborhood Hits	162	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

LU_HUMAN
NC score	0.063842 (rank : 1074)	θ value	θ > 10 (rank : 1403)
Query Neighborhood Hits	1243	Target Neighborhood Hits	283	Shared Neighborhood Hits	44
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

AHI1_HUMAN
NC score	0.063814 (rank : 1075)	θ value	θ > 10 (rank : 1246)
Query Neighborhood Hits	1243	Target Neighborhood Hits	537	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

PCLO_MOUSE
NC score	0.063622 (rank : 1076)	θ value	0.0961366 (rank : 785)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2275	Shared Neighborhood Hits	430
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PPIP1_MOUSE
NC score	0.063336 (rank : 1077)	θ value	θ > 10 (rank : 1499)
Query Neighborhood Hits	1243	Target Neighborhood Hits	377	Shared Neighborhood Hits	58
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

NRG2_MOUSE
NC score	0.063225 (rank : 1078)	θ value	θ > 10 (rank : 1466)
Query Neighborhood Hits	1243	Target Neighborhood Hits	392	Shared Neighborhood Hits	45
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

SN_HUMAN
NC score	0.062645 (rank : 1079)	θ value	θ > 10 (rank : 1566)
Query Neighborhood Hits	1243	Target Neighborhood Hits	434	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

PTN6_HUMAN
NC score	0.062554 (rank : 1080)	θ value	θ > 10 (rank : 1506)
Query Neighborhood Hits	1243	Target Neighborhood Hits	234	Shared Neighborhood Hits	47
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SN_MOUSE
NC score	0.062426 (rank : 1081)	θ value	θ > 10 (rank : 1567)
Query Neighborhood Hits	1243	Target Neighborhood Hits	416	Shared Neighborhood Hits	52
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

ITSN2_HUMAN
NC score	0.062211 (rank : 1082)	θ value	θ > 10 (rank : 1367)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1173	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ASPP1_MOUSE
NC score	0.062202 (rank : 1083)	θ value	0.365318 (rank : 845)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1244	Shared Neighborhood Hits	235
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BLNK_HUMAN
NC score	0.062143 (rank : 1084)	θ value	θ > 10 (rank : 1260)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

AHI1_MOUSE
NC score	0.061917 (rank : 1085)	θ value	θ > 10 (rank : 1247)
Query Neighborhood Hits	1243	Target Neighborhood Hits	496	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

LRIG1_MOUSE
NC score	0.061603 (rank : 1086)	θ value	θ > 10 (rank : 1392)
Query Neighborhood Hits	1243	Target Neighborhood Hits	627	Shared Neighborhood Hits	60
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

DNMBP_HUMAN
NC score	0.061591 (rank : 1087)	θ value	θ > 10 (rank : 1317)
Query Neighborhood Hits	1243	Target Neighborhood Hits	413	Shared Neighborhood Hits	65
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LRIG2_HUMAN
NC score	0.061460 (rank : 1088)	θ value	θ > 10 (rank : 1393)
Query Neighborhood Hits	1243	Target Neighborhood Hits	595	Shared Neighborhood Hits	60
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

CSKI2_MOUSE
NC score	0.061296 (rank : 1089)	θ value	1.38821 (rank : 951)
Query Neighborhood Hits	1243	Target Neighborhood Hits	812	Shared Neighborhood Hits	193
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

VCAM1_MOUSE
NC score	0.061249 (rank : 1090)	θ value	θ > 10 (rank : 1617)
Query Neighborhood Hits	1243	Target Neighborhood Hits	320	Shared Neighborhood Hits	40
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

PACN1_HUMAN
NC score	0.061211 (rank : 1091)	θ value	θ > 10 (rank : 1481)
Query Neighborhood Hits	1243	Target Neighborhood Hits	320	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RGS3_HUMAN
NC score	0.061206 (rank : 1092)	θ value	5.27518 (rank : 1116)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1375	Shared Neighborhood Hits	362
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

VINEX_MOUSE
NC score	0.060620 (rank : 1093)	θ value	θ > 10 (rank : 1619)
Query Neighborhood Hits	1243	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ITSN1_MOUSE
NC score	0.060594 (rank : 1094)	θ value	θ > 10 (rank : 1366)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1669	Shared Neighborhood Hits	187
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CD22_HUMAN
NC score	0.060301 (rank : 1095)	θ value	θ > 10 (rank : 1268)
Query Neighborhood Hits	1243	Target Neighborhood Hits	365	Shared Neighborhood Hits	41
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

LRIG2_MOUSE
NC score	0.060225 (rank : 1096)	θ value	θ > 10 (rank : 1394)
Query Neighborhood Hits	1243	Target Neighborhood Hits	586	Shared Neighborhood Hits	56
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

PACN2_MOUSE
NC score	0.060212 (rank : 1097)	θ value	θ > 10 (rank : 1484)
Query Neighborhood Hits	1243	Target Neighborhood Hits	382	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.059991 (rank : 1098)	θ value	θ > 10 (rank : 1483)
Query Neighborhood Hits	1243	Target Neighborhood Hits	339	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ITSN1_HUMAN
NC score	0.059874 (rank : 1099)	θ value	θ > 10 (rank : 1365)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1757	Shared Neighborhood Hits	204
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PRB4S_HUMAN
NC score	0.059511 (rank : 1100)	θ value	0.00665767 (rank : 685)
Query Neighborhood Hits	1243	Target Neighborhood Hits	330	Shared Neighborhood Hits	101
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SRRM2_MOUSE
NC score	0.059500 (rank : 1101)	θ value	6.88961 (rank : 1175)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1470	Shared Neighborhood Hits	277
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CI094_HUMAN
NC score	0.059434 (rank : 1102)	θ value	θ > 10 (rank : 1281)
Query Neighborhood Hits	1243	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

PACN1_MOUSE
NC score	0.059272 (rank : 1103)	θ value	θ > 10 (rank : 1482)
Query Neighborhood Hits	1243	Target Neighborhood Hits	283	Shared Neighborhood Hits	43
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RAGE_HUMAN
NC score	0.059045 (rank : 1104)	θ value	θ > 10 (rank : 1516)
Query Neighborhood Hits	1243	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

CEAM1_MOUSE
NC score	0.058950 (rank : 1105)	θ value	θ > 10 (rank : 1274)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	43
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

PACN3_HUMAN
NC score	0.058618 (rank : 1106)	θ value	θ > 10 (rank : 1485)
Query Neighborhood Hits	1243	Target Neighborhood Hits	385	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

JAM2_MOUSE
NC score	0.058401 (rank : 1107)	θ value	θ > 10 (rank : 1372)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

CSKI2_HUMAN
NC score	0.058161 (rank : 1108)	θ value	1.06291 (rank : 930)
Query Neighborhood Hits	1243	Target Neighborhood Hits	747	Shared Neighborhood Hits	149
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

OGFR_MOUSE
NC score	0.058111 (rank : 1109)	θ value	0.0330416 (rank : 740)
Query Neighborhood Hits	1243	Target Neighborhood Hits	584	Shared Neighborhood Hits	174
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

VCAM1_HUMAN
NC score	0.057953 (rank : 1110)	θ value	θ > 10 (rank : 1616)
Query Neighborhood Hits	1243	Target Neighborhood Hits	352	Shared Neighborhood Hits	40
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

ITSN2_MOUSE
NC score	0.057950 (rank : 1111)	θ value	θ > 10 (rank : 1368)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1371	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

BSN_HUMAN
NC score	0.057624 (rank : 1112)	θ value	0.813845 (rank : 904)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1537	Shared Neighborhood Hits	318
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

IL6RB_HUMAN
NC score	0.057552 (rank : 1113)	θ value	θ > 10 (rank : 1362)
Query Neighborhood Hits	1243	Target Neighborhood Hits	181	Shared Neighborhood Hits	37
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

HCFC2_MOUSE
NC score	0.057477 (rank : 1114)	θ value	θ > 10 (rank : 1357)
Query Neighborhood Hits	1243	Target Neighborhood Hits	97	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

SHAN2_MOUSE
NC score	0.057391 (rank : 1115)	θ value	5.27518 (rank : 1124)
Query Neighborhood Hits	1243	Target Neighborhood Hits	446	Shared Neighborhood Hits	101
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

MFA3L_MOUSE
NC score	0.057262 (rank : 1116)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	37
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

SIG10_HUMAN
NC score	0.057060 (rank : 1117)	θ value	θ > 10 (rank : 1560)
Query Neighborhood Hits	1243	Target Neighborhood Hits	363	Shared Neighborhood Hits	79
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

VINEX_HUMAN
NC score	0.057039 (rank : 1118)	θ value	θ > 10 (rank : 1618)
Query Neighborhood Hits	1243	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PRB3_HUMAN
NC score	0.056634 (rank : 1119)	θ value	0.00298849 (rank : 660)
Query Neighborhood Hits	1243	Target Neighborhood Hits	318	Shared Neighborhood Hits	102
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

SRRM1_MOUSE
NC score	0.056248 (rank : 1120)	θ value	5.27518 (rank : 1127)
Query Neighborhood Hits	1243	Target Neighborhood Hits	966	Shared Neighborhood Hits	234
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ITB4_HUMAN
NC score	0.056209 (rank : 1121)	θ value	θ > 10 (rank : 1364)
Query Neighborhood Hits	1243	Target Neighborhood Hits	458	Shared Neighborhood Hits	61
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

SOCS6_HUMAN
NC score	0.056182 (rank : 1122)	θ value	θ > 10 (rank : 1568)
Query Neighborhood Hits	1243	Target Neighborhood Hits	126	Shared Neighborhood Hits	30
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.055923 (rank : 1123)	θ value	θ > 10 (rank : 1569)
Query Neighborhood Hits	1243	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

PCLO_HUMAN
NC score	0.055908 (rank : 1124)	θ value	0.00869519 (rank : 692)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2046	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

CO7A1_HUMAN
NC score	0.055793 (rank : 1125)	θ value	θ > 10 (rank : 1297)
Query Neighborhood Hits	1243	Target Neighborhood Hits	807	Shared Neighborhood Hits	199
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

USH2A_MOUSE
NC score	0.055775 (rank : 1126)	θ value	θ > 10 (rank : 1609)
Query Neighborhood Hits	1243	Target Neighborhood Hits	626	Shared Neighborhood Hits	88
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

MAGE1_HUMAN
NC score	0.055772 (rank : 1127)	θ value	θ > 10 (rank : 1406)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1389	Shared Neighborhood Hits	346
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PACN3_MOUSE
NC score	0.055719 (rank : 1128)	θ value	θ > 10 (rank : 1486)
Query Neighborhood Hits	1243	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

KIRR2_HUMAN
NC score	0.055605 (rank : 1129)	θ value	θ > 10 (rank : 1382)
Query Neighborhood Hits	1243	Target Neighborhood Hits	321	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

NPTN_MOUSE
NC score	0.055593 (rank : 1130)	θ value	θ > 10 (rank : 1460)
Query Neighborhood Hits	1243	Target Neighborhood Hits	216	Shared Neighborhood Hits	35
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

MUC18_MOUSE
NC score	0.055575 (rank : 1131)	θ value	θ > 10 (rank : 1424)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

USH2A_HUMAN
NC score	0.055142 (rank : 1132)	θ value	θ > 10 (rank : 1608)
Query Neighborhood Hits	1243	Target Neighborhood Hits	600	Shared Neighborhood Hits	69
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

RAGE_MOUSE
NC score	0.055133 (rank : 1133)	θ value	θ > 10 (rank : 1517)
Query Neighborhood Hits	1243	Target Neighborhood Hits	295	Shared Neighborhood Hits	39
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

NCF1_HUMAN
NC score	0.055080 (rank : 1134)	θ value	θ > 10 (rank : 1445)
Query Neighborhood Hits	1243	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PRP1_HUMAN
NC score	0.055011 (rank : 1135)	θ value	0.00665767 (rank : 686)
Query Neighborhood Hits	1243	Target Neighborhood Hits	385	Shared Neighborhood Hits	118
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

LRIG3_MOUSE
NC score	0.054996 (rank : 1136)	θ value	θ > 10 (rank : 1396)
Query Neighborhood Hits	1243	Target Neighborhood Hits	611	Shared Neighborhood Hits	57
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

TENS4_HUMAN
NC score	0.054719 (rank : 1137)	θ value	θ > 10 (rank : 1592)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

SH22A_HUMAN
NC score	0.054599 (rank : 1138)	θ value	θ > 10 (rank : 1541)
Query Neighborhood Hits	1243	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SC24C_HUMAN
NC score	0.054472 (rank : 1139)	θ value	0.0961366 (rank : 792)
Query Neighborhood Hits	1243	Target Neighborhood Hits	662	Shared Neighborhood Hits	263
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

WBP11_HUMAN
NC score	0.054360 (rank : 1140)	θ value	0.00134147 (rank : 637)
Query Neighborhood Hits	1243	Target Neighborhood Hits	354	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

NCF1_MOUSE
NC score	0.054266 (rank : 1141)	θ value	θ > 10 (rank : 1446)
Query Neighborhood Hits	1243	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

JAM1_MOUSE
NC score	0.054164 (rank : 1142)	θ value	θ > 10 (rank : 1370)
Query Neighborhood Hits	1243	Target Neighborhood Hits	287	Shared Neighborhood Hits	33
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

SIG11_HUMAN
NC score	0.054066 (rank : 1143)	θ value	θ > 10 (rank : 1561)
Query Neighborhood Hits	1243	Target Neighborhood Hits	273	Shared Neighborhood Hits	44
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

WBP11_MOUSE
NC score	0.054008 (rank : 1144)	θ value	0.00102713 (rank : 631)
Query Neighborhood Hits	1243	Target Neighborhood Hits	362	Shared Neighborhood Hits	102
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

LRIG3_HUMAN
NC score	0.053656 (rank : 1145)	θ value	θ > 10 (rank : 1395)
Query Neighborhood Hits	1243	Target Neighborhood Hits	601	Shared Neighborhood Hits	59
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

TAF4_HUMAN
NC score	0.053614 (rank : 1146)	θ value	0.125558 (rank : 803)
Query Neighborhood Hits	1243	Target Neighborhood Hits	687	Shared Neighborhood Hits	165
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

PDZD8_HUMAN
NC score	0.053094 (rank : 1147)	θ value	θ > 10 (rank : 1487)
Query Neighborhood Hits	1243	Target Neighborhood Hits	185	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

RASF1_MOUSE
NC score	0.052996 (rank : 1148)	θ value	θ > 10 (rank : 1519)
Query Neighborhood Hits	1243	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

DGKQ_HUMAN
NC score	0.052811 (rank : 1149)	θ value	θ > 10 (rank : 1316)
Query Neighborhood Hits	1243	Target Neighborhood Hits	131	Shared Neighborhood Hits	37
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

NCOA6_HUMAN
NC score	0.052661 (rank : 1150)	θ value	θ > 10 (rank : 1449)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1202	Shared Neighborhood Hits	341
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

CD2AP_HUMAN
NC score	0.052634 (rank : 1151)	θ value	θ > 10 (rank : 1269)
Query Neighborhood Hits	1243	Target Neighborhood Hits	315	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

KIRR2_MOUSE
NC score	0.052605 (rank : 1152)	θ value	θ > 10 (rank : 1383)
Query Neighborhood Hits	1243	Target Neighborhood Hits	326	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

BUB1B_HUMAN
NC score	0.052458 (rank : 1153)	θ value	θ > 10 (rank : 1263)
Query Neighborhood Hits	1243	Target Neighborhood Hits	208	Shared Neighborhood Hits	104
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

FINC_MOUSE
NC score	0.052350 (rank : 1154)	θ value	θ > 10 (rank : 1334)
Query Neighborhood Hits	1243	Target Neighborhood Hits	309	Shared Neighborhood Hits	63
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

MISS_MOUSE
NC score	0.052276 (rank : 1155)	θ value	5.27518 (rank : 1107)
Query Neighborhood Hits	1243	Target Neighborhood Hits	444	Shared Neighborhood Hits	194
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

JAM1_HUMAN
NC score	0.052275 (rank : 1156)	θ value	θ > 10 (rank : 1369)
Query Neighborhood Hits	1243	Target Neighborhood Hits	294	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

DNMBP_MOUSE
NC score	0.052240 (rank : 1157)	θ value	θ > 10 (rank : 1318)
Query Neighborhood Hits	1243	Target Neighborhood Hits	435	Shared Neighborhood Hits	72
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ASPP1_HUMAN
NC score	0.052094 (rank : 1158)	θ value	θ > 10 (rank : 1255)
Query Neighborhood Hits	1243	Target Neighborhood Hits	956	Shared Neighborhood Hits	126
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

KIRR1_HUMAN
NC score	0.051841 (rank : 1159)	θ value	θ > 10 (rank : 1381)
Query Neighborhood Hits	1243	Target Neighborhood Hits	401	Shared Neighborhood Hits	46
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

CEAM5_HUMAN
NC score	0.051601 (rank : 1160)	θ value	θ > 10 (rank : 1275)
Query Neighborhood Hits	1243	Target Neighborhood Hits	343	Shared Neighborhood Hits	44
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

ASPP2_HUMAN
NC score	0.051577 (rank : 1161)	θ value	6.88961 (rank : 1135)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1156	Shared Neighborhood Hits	166
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

PTPRU_HUMAN
NC score	0.051552 (rank : 1162)	θ value	θ > 10 (rank : 1512)
Query Neighborhood Hits	1243	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

ABI2_HUMAN
NC score	0.051474 (rank : 1163)	θ value	θ > 10 (rank : 1245)
Query Neighborhood Hits	1243	Target Neighborhood Hits	350	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

UN13A_HUMAN
NC score	0.051376 (rank : 1164)	θ value	θ > 10 (rank : 1606)
Query Neighborhood Hits	1243	Target Neighborhood Hits	285	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

MUC18_HUMAN
NC score	0.051301 (rank : 1165)	θ value	θ > 10 (rank : 1423)
Query Neighborhood Hits	1243	Target Neighborhood Hits	275	Shared Neighborhood Hits	39
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

FINC_HUMAN
NC score	0.051282 (rank : 1166)	θ value	θ > 10 (rank : 1333)
Query Neighborhood Hits	1243	Target Neighborhood Hits	302	Shared Neighborhood Hits	61
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

SSBP4_HUMAN
NC score	0.051268 (rank : 1167)	θ value	6.88961 (rank : 1176)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	267
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

KAZD1_MOUSE
NC score	0.051076 (rank : 1168)	θ value	θ > 10 (rank : 1375)
Query Neighborhood Hits	1243	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

SRBS1_HUMAN
NC score	0.051056 (rank : 1169)	θ value	θ > 10 (rank : 1572)
Query Neighborhood Hits	1243	Target Neighborhood Hits	396	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

BCAR3_MOUSE
NC score	0.050999 (rank : 1170)	θ value	θ > 10 (rank : 1258)
Query Neighborhood Hits	1243	Target Neighborhood Hits	127	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ES8L1_MOUSE
NC score	0.050835 (rank : 1171)	θ value	θ > 10 (rank : 1326)
Query Neighborhood Hits	1243	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ATL3_HUMAN
NC score	0.050565 (rank : 1172)	θ value	θ > 10 (rank : 1256)
Query Neighborhood Hits	1243	Target Neighborhood Hits	414	Shared Neighborhood Hits	47
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

COCA1_MOUSE
NC score	0.050483 (rank : 1173)	θ value	0.0113563 (rank : 697)
Query Neighborhood Hits	1243	Target Neighborhood Hits	467	Shared Neighborhood Hits	126
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

BCAR3_HUMAN
NC score	0.050472 (rank : 1174)	θ value	θ > 10 (rank : 1257)
Query Neighborhood Hits	1243	Target Neighborhood Hits	129	Shared Neighborhood Hits	27
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

UN13B_HUMAN
NC score	0.050339 (rank : 1175)	θ value	θ > 10 (rank : 1607)
Query Neighborhood Hits	1243	Target Neighborhood Hits	217	Shared Neighborhood Hits	45
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

PRP2_MOUSE
NC score	0.050307 (rank : 1176)	θ value	0.47712 (rank : 877)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	108
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

ARHG7_MOUSE
NC score	0.050293 (rank : 1177)	θ value	θ > 10 (rank : 1254)
Query Neighborhood Hits	1243	Target Neighborhood Hits	396	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

BCL9_HUMAN
NC score	0.050016 (rank : 1178)	θ value	θ > 10 (rank : 1259)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1008	Shared Neighborhood Hits	296
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

SASH1_HUMAN
NC score	0.049948 (rank : 1179)	θ value	5.27518 (rank : 1119)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	97
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

MBD6_HUMAN
NC score	0.049820 (rank : 1180)	θ value	0.125558 (rank : 801)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	99
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

GRIN1_HUMAN
NC score	0.049808 (rank : 1181)	θ value	0.47712 (rank : 869)
Query Neighborhood Hits	1243	Target Neighborhood Hits	681	Shared Neighborhood Hits	209
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

PRR12_HUMAN
NC score	0.049612 (rank : 1182)	θ value	0.279714 (rank : 838)
Query Neighborhood Hits	1243	Target Neighborhood Hits	460	Shared Neighborhood Hits	124
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SAPS1_HUMAN
NC score	0.049073 (rank : 1183)	θ value	0.00390308 (rank : 673)
Query Neighborhood Hits	1243	Target Neighborhood Hits	704	Shared Neighborhood Hits	241
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CO5A2_HUMAN
NC score	0.048060 (rank : 1184)	θ value	3.0926 (rank : 1034)
Query Neighborhood Hits	1243	Target Neighborhood Hits	760	Shared Neighborhood Hits	203
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CEL_HUMAN
NC score	0.047775 (rank : 1185)	θ value	5.27518 (rank : 1093)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	299
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

COCA1_HUMAN
NC score	0.047550 (rank : 1186)	θ value	0.0252991 (rank : 727)
Query Neighborhood Hits	1243	Target Neighborhood Hits	458	Shared Neighborhood Hits	113
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

SASH1_MOUSE
NC score	0.047060 (rank : 1187)	θ value	2.36792 (rank : 1015)
Query Neighborhood Hits	1243	Target Neighborhood Hits	263	Shared Neighborhood Hits	83
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SHAN1_HUMAN
NC score	0.046564 (rank : 1188)	θ value	5.27518 (rank : 1123)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1041	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

WASIP_HUMAN
NC score	0.046311 (rank : 1189)	θ value	1.06291 (rank : 944)
Query Neighborhood Hits	1243	Target Neighborhood Hits	458	Shared Neighborhood Hits	130
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
NC score	0.046229 (rank : 1190)	θ value	2.36792 (rank : 1020)
Query Neighborhood Hits	1243	Target Neighborhood Hits	392	Shared Neighborhood Hits	115
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

SRRM2_HUMAN
NC score	0.045783 (rank : 1191)	θ value	1.81305 (rank : 989)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1296	Shared Neighborhood Hits	230
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ATN1_HUMAN
NC score	0.045461 (rank : 1192)	θ value	0.00665767 (rank : 682)
Query Neighborhood Hits	1243	Target Neighborhood Hits	676	Shared Neighborhood Hits	153
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

WASL_HUMAN
NC score	0.045330 (rank : 1193)	θ value	0.125558 (rank : 804)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	117
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASL_MOUSE
NC score	0.044559 (rank : 1194)	θ value	0.0736092 (rank : 773)
Query Neighborhood Hits	1243	Target Neighborhood Hits	339	Shared Neighborhood Hits	113
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

TENS1_HUMAN
NC score	0.044355 (rank : 1195)	θ value	8.99809 (rank : 1243)
Query Neighborhood Hits	1243	Target Neighborhood Hits	400	Shared Neighborhood Hits	112
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

PCQAP_HUMAN
NC score	0.044075 (rank : 1196)	θ value	0.125558 (rank : 802)
Query Neighborhood Hits	1243	Target Neighborhood Hits	549	Shared Neighborhood Hits	115
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

SON_MOUSE
NC score	0.043765 (rank : 1197)	θ value	8.99809 (rank : 1237)
Query Neighborhood Hits	1243	Target Neighborhood Hits	957	Shared Neighborhood Hits	250
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

PCQAP_MOUSE
NC score	0.043498 (rank : 1198)	θ value	0.0252991 (rank : 731)
Query Neighborhood Hits	1243	Target Neighborhood Hits	506	Shared Neighborhood Hits	99
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

SNPC4_HUMAN
NC score	0.043425 (rank : 1199)	θ value	2.36792 (rank : 1016)
Query Neighborhood Hits	1243	Target Neighborhood Hits	589	Shared Neighborhood Hits	215
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

PELP1_MOUSE
NC score	0.043397 (rank : 1200)	θ value	6.88961 (rank : 1163)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	202
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

MDC1_HUMAN
NC score	0.043309 (rank : 1201)	θ value	5.27518 (rank : 1106)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1446	Shared Neighborhood Hits	263
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SFPQ_HUMAN
NC score	0.043128 (rank : 1202)	θ value	0.0113563 (rank : 705)
Query Neighborhood Hits	1243	Target Neighborhood Hits	986	Shared Neighborhood Hits	176
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

COHA1_MOUSE
NC score	0.042727 (rank : 1203)	θ value	0.0113563 (rank : 698)
Query Neighborhood Hits	1243	Target Neighborhood Hits	414	Shared Neighborhood Hits	124
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

LPP_HUMAN
NC score	0.042415 (rank : 1204)	θ value	6.88961 (rank : 1154)
Query Neighborhood Hits	1243	Target Neighborhood Hits	775	Shared Neighborhood Hits	234
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

DGKK_HUMAN
NC score	0.042304 (rank : 1205)	θ value	0.0563607 (rank : 755)
Query Neighborhood Hits	1243	Target Neighborhood Hits	378	Shared Neighborhood Hits	103
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

CO4A4_HUMAN
NC score	0.042171 (rank : 1206)	θ value	0.0563607 (rank : 754)
Query Neighborhood Hits	1243	Target Neighborhood Hits	440	Shared Neighborhood Hits	134
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

CPSF6_HUMAN
NC score	0.042031 (rank : 1207)	θ value	0.00228821 (rank : 642)
Query Neighborhood Hits	1243	Target Neighborhood Hits	359	Shared Neighborhood Hits	104
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
NC score	0.041779 (rank : 1208)	θ value	0.00509761 (rank : 680)
Query Neighborhood Hits	1243	Target Neighborhood Hits	356	Shared Neighborhood Hits	105
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

IL3B2_MOUSE
NC score	0.041662 (rank : 1209)	θ value	0.279714 (rank : 834)
Query Neighborhood Hits	1243	Target Neighborhood Hits	372	Shared Neighborhood Hits	149
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

CO4A2_HUMAN
NC score	0.041372 (rank : 1210)	θ value	0.163984 (rank : 807)
Query Neighborhood Hits	1243	Target Neighborhood Hits	454	Shared Neighborhood Hits	142
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CO3A1_MOUSE
NC score	0.040968 (rank : 1211)	θ value	0.0961366 (rank : 776)
Query Neighborhood Hits	1243	Target Neighborhood Hits	466	Shared Neighborhood Hits	124
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

SFPQ_MOUSE
NC score	0.040966 (rank : 1212)	θ value	0.00390308 (rank : 674)
Query Neighborhood Hits	1243	Target Neighborhood Hits	958	Shared Neighborhood Hits	166
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

ENAH_MOUSE
NC score	0.040793 (rank : 1213)	θ value	0.0193708 (rank : 719)
Query Neighborhood Hits	1243	Target Neighborhood Hits	919	Shared Neighborhood Hits	178
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

RAPH1_HUMAN
NC score	0.040658 (rank : 1214)	θ value	0.0431538 (rank : 751)
Query Neighborhood Hits	1243	Target Neighborhood Hits	593	Shared Neighborhood Hits	146
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RIMB1_HUMAN
NC score	0.040495 (rank : 1215)	θ value	3.0926 (rank : 1053)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1479	Shared Neighborhood Hits	238
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CO4A2_MOUSE
NC score	0.039758 (rank : 1216)	θ value	5.27518 (rank : 1096)
Query Neighborhood Hits	1243	Target Neighborhood Hits	492	Shared Neighborhood Hits	153
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CECR2_HUMAN
NC score	0.039418 (rank : 1217)	θ value	0.0563607 (rank : 753)
Query Neighborhood Hits	1243	Target Neighborhood Hits	543	Shared Neighborhood Hits	191
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

COHA1_HUMAN
NC score	0.039165 (rank : 1218)	θ value	0.00869519 (rank : 688)
Query Neighborhood Hits	1243	Target Neighborhood Hits	400	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

IL3RB_MOUSE
NC score	0.039074 (rank : 1219)	θ value	0.365318 (rank : 855)
Query Neighborhood Hits	1243	Target Neighborhood Hits	355	Shared Neighborhood Hits	139
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

BAT2_MOUSE
NC score	0.039050 (rank : 1220)	θ value	1.06291 (rank : 928)
Query Neighborhood Hits	1243	Target Neighborhood Hits	947	Shared Neighborhood Hits	255
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

K1802_MOUSE
NC score	0.038896 (rank : 1221)	θ value	0.0961366 (rank : 781)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1596	Shared Neighborhood Hits	306
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CO2A1_HUMAN
NC score	0.038682 (rank : 1222)	θ value	0.163984 (rank : 805)
Query Neighborhood Hits	1243	Target Neighborhood Hits	486	Shared Neighborhood Hits	141
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO4A1_MOUSE
NC score	0.038664 (rank : 1223)	θ value	0.813845 (rank : 905)
Query Neighborhood Hits	1243	Target Neighborhood Hits	450	Shared Neighborhood Hits	138
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO4A3_HUMAN
NC score	0.038518 (rank : 1224)	θ value	0.813845 (rank : 906)
Query Neighborhood Hits	1243	Target Neighborhood Hits	421	Shared Neighborhood Hits	120
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CO1A1_HUMAN
NC score	0.038248 (rank : 1225)	θ value	0.0252991 (rank : 726)
Query Neighborhood Hits	1243	Target Neighborhood Hits	475	Shared Neighborhood Hits	123
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

SPR1B_MOUSE
NC score	0.038218 (rank : 1226)	θ value	0.62314 (rank : 902)
Query Neighborhood Hits	1243	Target Neighborhood Hits	395	Shared Neighborhood Hits	150
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

PDCD7_MOUSE
NC score	0.038144 (rank : 1227)	θ value	0.0431538 (rank : 749)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

CO1A1_MOUSE
NC score	0.038004 (rank : 1228)	θ value	0.0961366 (rank : 775)
Query Neighborhood Hits	1243	Target Neighborhood Hits	457	Shared Neighborhood Hits	125
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CSF1_HUMAN
NC score	0.037853 (rank : 1229)	θ value	0.0736092 (rank : 763)
Query Neighborhood Hits	1243	Target Neighborhood Hits	258	Shared Neighborhood Hits	105
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

COBA2_MOUSE
NC score	0.037825 (rank : 1230)	θ value	4.03905 (rank : 1062)
Query Neighborhood Hits	1243	Target Neighborhood Hits	501	Shared Neighborhood Hits	142
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

PRP5_HUMAN
NC score	0.037681 (rank : 1231)	θ value	2.36792 (rank : 1014)
Query Neighborhood Hits	1243	Target Neighborhood Hits	108	Shared Neighborhood Hits	45
SwissProt Accessions	P04281	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide IB-1.

CO4A1_HUMAN
NC score	0.037586 (rank : 1232)	θ value	3.0926 (rank : 1033)
Query Neighborhood Hits	1243	Target Neighborhood Hits	425	Shared Neighborhood Hits	127
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

MLL2_HUMAN
NC score	0.037503 (rank : 1233)	θ value	3.0926 (rank : 1044)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1788	Shared Neighborhood Hits	325
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NFH_MOUSE
NC score	0.037364 (rank : 1234)	θ value	0.279714 (rank : 837)
Query Neighborhood Hits	1243	Target Neighborhood Hits	2247	Shared Neighborhood Hits	376
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

WASP_MOUSE
NC score	0.037185 (rank : 1235)	θ value	0.47712 (rank : 884)
Query Neighborhood Hits	1243	Target Neighborhood Hits	223	Shared Neighborhood Hits	88
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

CRSP2_HUMAN
NC score	0.036585 (rank : 1236)	θ value	0.365318 (rank : 853)
Query Neighborhood Hits	1243	Target Neighborhood Hits	380	Shared Neighborhood Hits	138
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CIC_HUMAN
NC score	0.036581 (rank : 1237)	θ value	1.38821 (rank : 947)
Query Neighborhood Hits	1243	Target Neighborhood Hits	992	Shared Neighborhood Hits	290
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

GSCR1_HUMAN
NC score	0.036571 (rank : 1238)	θ value	8.99809 (rank : 1207)
Query Neighborhood Hits	1243	Target Neighborhood Hits	674	Shared Neighborhood Hits	171
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

PDCD7_HUMAN
NC score	0.036494 (rank : 1239)	θ value	0.0113563 (rank : 704)
Query Neighborhood Hits	1243	Target Neighborhood Hits	255	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

COBA2_HUMAN
NC score	0.036165 (rank : 1240)	θ value	0.365318 (rank : 852)
Query Neighborhood Hits	1243	Target Neighborhood Hits	408	Shared Neighborhood Hits	113
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

GGN_MOUSE
NC score	0.035961 (rank : 1241)	θ value	1.38821 (rank : 955)
Query Neighborhood Hits	1243	Target Neighborhood Hits	311	Shared Neighborhood Hits	101
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

COGA1_HUMAN
NC score	0.035844 (rank : 1242)	θ value	2.36792 (rank : 995)
Query Neighborhood Hits	1243	Target Neighborhood Hits	345	Shared Neighborhood Hits	107
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

CEND3_MOUSE
NC score	0.035327 (rank : 1243)	θ value	0.00298849 (rank : 651)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CO2A1_MOUSE
NC score	0.035240 (rank : 1244)	θ value	0.163984 (rank : 806)
Query Neighborhood Hits	1243	Target Neighborhood Hits	483	Shared Neighborhood Hits	135
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

NCOR2_HUMAN
NC score	0.035110 (rank : 1245)	θ value	0.62314 (rank : 893)
Query Neighborhood Hits	1243	Target Neighborhood Hits	870	Shared Neighborhood Hits	198
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

TGON2_HUMAN
NC score	0.034735 (rank : 1246)	θ value	0.279714 (rank : 841)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1037	Shared Neighborhood Hits	188
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CO1A2_MOUSE
NC score	0.034679 (rank : 1247)	θ value	8.99809 (rank : 1198)
Query Neighborhood Hits	1243	Target Neighborhood Hits	388	Shared Neighborhood Hits	110
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO9A2_MOUSE
NC score	0.034465 (rank : 1248)	θ value	0.62314 (rank : 889)
Query Neighborhood Hits	1243	Target Neighborhood Hits	279	Shared Neighborhood Hits	86
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

MEGF9_MOUSE
NC score	0.034411 (rank : 1249)	θ value	0.47712 (rank : 874)
Query Neighborhood Hits	1243	Target Neighborhood Hits	896	Shared Neighborhood Hits	205
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

RP1L1_HUMAN
NC score	0.034369 (rank : 1250)	θ value	0.163984 (rank : 813)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1072	Shared Neighborhood Hits	199
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

COEA1_HUMAN
NC score	0.034349 (rank : 1251)	θ value	0.47712 (rank : 863)
Query Neighborhood Hits	1243	Target Neighborhood Hits	427	Shared Neighborhood Hits	107
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

COIA1_HUMAN
NC score	0.034290 (rank : 1252)	θ value	3.0926 (rank : 1036)
Query Neighborhood Hits	1243	Target Neighborhood Hits	447	Shared Neighborhood Hits	146
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

COBA1_HUMAN
NC score	0.034221 (rank : 1253)	θ value	0.47712 (rank : 862)
Query Neighborhood Hits	1243	Target Neighborhood Hits	491	Shared Neighborhood Hits	135
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

WASF4_HUMAN
NC score	0.034069 (rank : 1254)	θ value	0.47712 (rank : 883)
Query Neighborhood Hits	1243	Target Neighborhood Hits	282	Shared Neighborhood Hits	102
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

FA47A_HUMAN
NC score	0.034026 (rank : 1255)	θ value	3.0926 (rank : 1038)
Query Neighborhood Hits	1243	Target Neighborhood Hits	451	Shared Neighborhood Hits	147
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

COFA1_HUMAN
NC score	0.034021 (rank : 1256)	θ value	0.0961366 (rank : 777)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	92
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

COIA1_MOUSE
NC score	0.033852 (rank : 1257)	θ value	2.36792 (rank : 996)
Query Neighborhood Hits	1243	Target Neighborhood Hits	481	Shared Neighborhood Hits	132
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CO4A5_HUMAN
NC score	0.033790 (rank : 1258)	θ value	0.813845 (rank : 907)
Query Neighborhood Hits	1243	Target Neighborhood Hits	383	Shared Neighborhood Hits	109
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

BAT3_MOUSE
NC score	0.033786 (rank : 1259)	θ value	4.03905 (rank : 1060)
Query Neighborhood Hits	1243	Target Neighborhood Hits	518	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

COBA1_MOUSE
NC score	0.033719 (rank : 1260)	θ value	0.813845 (rank : 908)
Query Neighborhood Hits	1243	Target Neighborhood Hits	487	Shared Neighborhood Hits	135
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

ARI1A_HUMAN
NC score	0.033458 (rank : 1261)	θ value	8.99809 (rank : 1189)
Query Neighborhood Hits	1243	Target Neighborhood Hits	787	Shared Neighborhood Hits	229
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ARI1B_HUMAN
NC score	0.033322 (rank : 1262)	θ value	0.365318 (rank : 844)
Query Neighborhood Hits	1243	Target Neighborhood Hits	567	Shared Neighborhood Hits	159
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

MARCS_MOUSE
NC score	0.033103 (rank : 1263)	θ value	0.279714 (rank : 836)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

CN155_HUMAN
NC score	0.032957 (rank : 1264)	θ value	1.38821 (rank : 950)
Query Neighborhood Hits	1243	Target Neighborhood Hits	385	Shared Neighborhood Hits	83
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CN032_MOUSE
NC score	0.032786 (rank : 1265)	θ value	1.38821 (rank : 949)
Query Neighborhood Hits	1243	Target Neighborhood Hits	233	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

SMR3B_HUMAN
NC score	0.032241 (rank : 1266)	θ value	0.47712 (rank : 878)
Query Neighborhood Hits	1243	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	P02814, Q9UBN0, Q9UCT0	Gene names	SMR3B, PBII, PROL3
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog B precursor (Proline-rich protein 3) (Proline-rich peptide P-B) [Contains: Peptide P-A; Peptide D1A].

TAU_HUMAN
NC score	0.032239 (rank : 1267)	θ value	5.27518 (rank : 1129)
Query Neighborhood Hits	1243	Target Neighborhood Hits	448	Shared Neighborhood Hits	146
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

CO5A1_MOUSE
NC score	0.032195 (rank : 1268)	θ value	5.27518 (rank : 1098)
Query Neighborhood Hits	1243	Target Neighborhood Hits	419	Shared Neighborhood Hits	124
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

SYN1_HUMAN
NC score	0.032143 (rank : 1269)	θ value	0.279714 (rank : 840)
Query Neighborhood Hits	1243	Target Neighborhood Hits	419	Shared Neighborhood Hits	125
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

GNAS1_MOUSE
NC score	0.032141 (rank : 1270)	θ value	0.00102713 (rank : 626)
Query Neighborhood Hits	1243	Target Neighborhood Hits	651	Shared Neighborhood Hits	211
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

WASP_HUMAN
NC score	0.031932 (rank : 1271)	θ value	6.88961 (rank : 1184)
Query Neighborhood Hits	1243	Target Neighborhood Hits	195	Shared Neighborhood Hits	82
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

CO5A1_HUMAN
NC score	0.031621 (rank : 1272)	θ value	5.27518 (rank : 1097)
Query Neighborhood Hits	1243	Target Neighborhood Hits	434	Shared Neighborhood Hits	125
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

WASF2_MOUSE
NC score	0.031558 (rank : 1273)	θ value	1.38821 (rank : 966)
Query Neighborhood Hits	1243	Target Neighborhood Hits	315	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

MAP1A_HUMAN
NC score	0.031518 (rank : 1274)	θ value	1.38821 (rank : 959)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1626	Shared Neighborhood Hits	277
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ENAH_HUMAN
NC score	0.031487 (rank : 1275)	θ value	0.813845 (rank : 911)
Query Neighborhood Hits	1243	Target Neighborhood Hits	784	Shared Neighborhood Hits	129
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

MILK1_MOUSE
NC score	0.031477 (rank : 1276)	θ value	1.81305 (rank : 985)
Query Neighborhood Hits	1243	Target Neighborhood Hits	788	Shared Neighborhood Hits	215
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

FMN2_HUMAN
NC score	0.031048 (rank : 1277)	θ value	1.38821 (rank : 953)
Query Neighborhood Hits	1243	Target Neighborhood Hits	484	Shared Neighborhood Hits	124
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

CBP_HUMAN
NC score	0.031028 (rank : 1278)	θ value	3.0926 (rank : 1029)
Query Neighborhood Hits	1243	Target Neighborhood Hits	941	Shared Neighborhood Hits	245
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

WASF2_HUMAN
NC score	0.030948 (rank : 1279)	θ value	0.365318 (rank : 860)
Query Neighborhood Hits	1243	Target Neighborhood Hits	280	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

COFA1_MOUSE
NC score	0.030892 (rank : 1280)	θ value	3.0926 (rank : 1035)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	95
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

CNOT3_MOUSE
NC score	0.030727 (rank : 1281)	θ value	0.365318 (rank : 850)
Query Neighborhood Hits	1243	Target Neighborhood Hits	504	Shared Neighborhood Hits	105
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

TB182_HUMAN
NC score	0.030633 (rank : 1282)	θ value	0.47712 (rank : 879)
Query Neighborhood Hits	1243	Target Neighborhood Hits	414	Shared Neighborhood Hits	104
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

CO8A2_HUMAN
NC score	0.030630 (rank : 1283)	θ value	0.365318 (rank : 851)
Query Neighborhood Hits	1243	Target Neighborhood Hits	299	Shared Neighborhood Hits	89
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CI079_HUMAN
NC score	0.030511 (rank : 1284)	θ value	0.0431538 (rank : 745)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	84
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CABIN_HUMAN
NC score	0.030460 (rank : 1285)	θ value	6.88961 (rank : 1137)
Query Neighborhood Hits	1243	Target Neighborhood Hits	490	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

SELPL_MOUSE
NC score	0.030259 (rank : 1286)	θ value	4.03905 (rank : 1082)
Query Neighborhood Hits	1243	Target Neighborhood Hits	588	Shared Neighborhood Hits	151
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

CRTC1_HUMAN
NC score	0.030089 (rank : 1287)	θ value	4.03905 (rank : 1065)
Query Neighborhood Hits	1243	Target Neighborhood Hits	319	Shared Neighborhood Hits	112
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

RERE_HUMAN
NC score	0.029697 (rank : 1288)	θ value	0.813845 (rank : 923)
Query Neighborhood Hits	1243	Target Neighborhood Hits	779	Shared Neighborhood Hits	173
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

PGCA_HUMAN
NC score	0.029653 (rank : 1289)	θ value	8.40245e-06 (rank : 491)
Query Neighborhood Hits	1243	Target Neighborhood Hits	821	Shared Neighborhood Hits	129
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

CO8A2_MOUSE
NC score	0.029572 (rank : 1290)	θ value	0.21417 (rank : 817)
Query Neighborhood Hits	1243	Target Neighborhood Hits	273	Shared Neighborhood Hits	90
SwissProt Accessions	P25318, Q68ED0, Q6KAQ4, Q6P1C4	Gene names	Col8a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

WASF1_MOUSE
NC score	0.029205 (rank : 1291)	θ value	3.0926 (rank : 1057)
Query Neighborhood Hits	1243	Target Neighborhood Hits	261	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

CRSP7_HUMAN
NC score	0.029038 (rank : 1292)	θ value	6.88961 (rank : 1141)
Query Neighborhood Hits	1243	Target Neighborhood Hits	247	Shared Neighborhood Hits	92
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

AB1IP_MOUSE
NC score	0.028639 (rank : 1293)	θ value	0.00390308 (rank : 664)
Query Neighborhood Hits	1243	Target Neighborhood Hits	181	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

RP3A_MOUSE
NC score	0.028590 (rank : 1294)	θ value	1.06291 (rank : 940)
Query Neighborhood Hits	1243	Target Neighborhood Hits	510	Shared Neighborhood Hits	148
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RUSC2_MOUSE
NC score	0.028338 (rank : 1295)	θ value	0.813845 (rank : 925)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	95
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

FMNL_HUMAN
NC score	0.028284 (rank : 1296)	θ value	1.38821 (rank : 954)
Query Neighborhood Hits	1243	Target Neighborhood Hits	529	Shared Neighborhood Hits	120
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

PLXB1_MOUSE
NC score	0.028236 (rank : 1297)	θ value	0.0961366 (rank : 788)
Query Neighborhood Hits	1243	Target Neighborhood Hits	259	Shared Neighborhood Hits	85
SwissProt Accessions	Q8CJH3, Q6ZQC3, Q80ZZ1	Gene names	Plxnb1, Kiaa0407
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor.

CN032_HUMAN
NC score	0.027612 (rank : 1298)	θ value	8.99809 (rank : 1197)
Query Neighborhood Hits	1243	Target Neighborhood Hits	267	Shared Neighborhood Hits	90
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CO8A1_MOUSE
NC score	0.027505 (rank : 1299)	θ value	0.0193708 (rank : 718)
Query Neighborhood Hits	1243	Target Neighborhood Hits	251	Shared Neighborhood Hits	73
SwissProt Accessions	Q00780, Q9D2V4	Gene names	Col8a1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor.

TM108_MOUSE
NC score	0.027488 (rank : 1300)	θ value	0.21417 (rank : 826)
Query Neighborhood Hits	1243	Target Neighborhood Hits	336	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

COEA1_MOUSE
NC score	0.027482 (rank : 1301)	θ value	0.813845 (rank : 909)
Query Neighborhood Hits	1243	Target Neighborhood Hits	402	Shared Neighborhood Hits	94
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

PO121_HUMAN
NC score	0.027463 (rank : 1302)	θ value	6.88961 (rank : 1166)
Query Neighborhood Hits	1243	Target Neighborhood Hits	344	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

WASF1_HUMAN
NC score	0.027344 (rank : 1303)	θ value	1.06291 (rank : 943)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	75
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

YLPM1_MOUSE
NC score	0.027220 (rank : 1304)	θ value	1.06291 (rank : 945)
Query Neighborhood Hits	1243	Target Neighborhood Hits	505	Shared Neighborhood Hits	118
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SMR1_MOUSE
NC score	0.027108 (rank : 1305)	θ value	0.62314 (rank : 901)
Query Neighborhood Hits	1243	Target Neighborhood Hits	103	Shared Neighborhood Hits	41
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

SYN1_MOUSE
NC score	0.027064 (rank : 1306)	θ value	6.88961 (rank : 1177)
Query Neighborhood Hits	1243	Target Neighborhood Hits	363	Shared Neighborhood Hits	116
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

TMUB1_HUMAN
NC score	0.026540 (rank : 1307)	θ value	0.00228821 (rank : 648)
Query Neighborhood Hits	1243	Target Neighborhood Hits	30	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BVT8	Gene names	TMUB1, C7orf21
Domain Architecture
Description	Transmembrane and ubiquitin-like domain-containing protein 1 (Ubiquitin-like protein SB144).

CIC_MOUSE
NC score	0.026496 (rank : 1308)	θ value	4.03905 (rank : 1061)
Query Neighborhood Hits	1243	Target Neighborhood Hits	742	Shared Neighborhood Hits	198
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

FMN2_MOUSE
NC score	0.026479 (rank : 1309)	θ value	0.813845 (rank : 912)
Query Neighborhood Hits	1243	Target Neighborhood Hits	349	Shared Neighborhood Hits	103
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

CO8A1_HUMAN
NC score	0.026227 (rank : 1310)	θ value	0.62314 (rank : 888)
Query Neighborhood Hits	1243	Target Neighborhood Hits	288	Shared Neighborhood Hits	78
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

K1802_HUMAN
NC score	0.026158 (rank : 1311)	θ value	0.0148317 (rank : 708)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1378	Shared Neighborhood Hits	256
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SRBP1_MOUSE
NC score	0.026008 (rank : 1312)	θ value	0.0961366 (rank : 794)
Query Neighborhood Hits	1243	Target Neighborhood Hits	384	Shared Neighborhood Hits	126
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

RBM12_HUMAN
NC score	0.025968 (rank : 1313)	θ value	0.0563607 (rank : 761)
Query Neighborhood Hits	1243	Target Neighborhood Hits	298	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

T22D2_HUMAN
NC score	0.025899 (rank : 1314)	θ value	0.813845 (rank : 926)
Query Neighborhood Hits	1243	Target Neighborhood Hits	250	Shared Neighborhood Hits	76
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

GAK5_HUMAN
NC score	0.025685 (rank : 1315)	θ value	0.813845 (rank : 916)
Query Neighborhood Hits	1243	Target Neighborhood Hits	429	Shared Neighborhood Hits	159
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MAP4_HUMAN
NC score	0.025596 (rank : 1316)	θ value	0.279714 (rank : 835)
Query Neighborhood Hits	1243	Target Neighborhood Hits	428	Shared Neighborhood Hits	108
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

GAK6_HUMAN
NC score	0.025368 (rank : 1317)	θ value	0.813845 (rank : 917)
Query Neighborhood Hits	1243	Target Neighborhood Hits	392	Shared Neighborhood Hits	152
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.025093 (rank : 1318)	θ value	0.813845 (rank : 913)
Query Neighborhood Hits	1243	Target Neighborhood Hits	409	Shared Neighborhood Hits	158
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

NFRKB_MOUSE
NC score	0.025010 (rank : 1319)	θ value	1.06291 (rank : 938)
Query Neighborhood Hits	1243	Target Neighborhood Hits	393	Shared Neighborhood Hits	115
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

ZYX_HUMAN
NC score	0.024983 (rank : 1320)	θ value	0.0193708 (rank : 725)
Query Neighborhood Hits	1243	Target Neighborhood Hits	387	Shared Neighborhood Hits	85
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

GAK2_HUMAN
NC score	0.024922 (rank : 1321)	θ value	0.813845 (rank : 914)
Query Neighborhood Hits	1243	Target Neighborhood Hits	406	Shared Neighborhood Hits	156
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
NC score	0.024885 (rank : 1322)	θ value	0.813845 (rank : 915)
Query Neighborhood Hits	1243	Target Neighborhood Hits	415	Shared Neighborhood Hits	159
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

SMR3A_HUMAN
NC score	0.024697 (rank : 1323)	θ value	6.88961 (rank : 1174)
Query Neighborhood Hits	1243	Target Neighborhood Hits	93	Shared Neighborhood Hits	36
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

CJ108_HUMAN
NC score	0.024684 (rank : 1324)	θ value	6.88961 (rank : 1140)
Query Neighborhood Hits	1243	Target Neighborhood Hits	165	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

SMRC1_HUMAN
NC score	0.024680 (rank : 1325)	θ value	0.0330416 (rank : 741)
Query Neighborhood Hits	1243	Target Neighborhood Hits	375	Shared Neighborhood Hits	62
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

RP3A_HUMAN
NC score	0.024570 (rank : 1326)	θ value	0.0252991 (rank : 734)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

EMID1_MOUSE
NC score	0.024509 (rank : 1327)	θ value	1.81305 (rank : 976)
Query Neighborhood Hits	1243	Target Neighborhood Hits	230	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VF5	Gene names	Emid1, Emu1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

SCAR3_MOUSE
NC score	0.024486 (rank : 1328)	θ value	0.279714 (rank : 839)
Query Neighborhood Hits	1243	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C850, Q8C6N1	Gene names	Scara3
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3.

ZYX_MOUSE
NC score	0.024383 (rank : 1329)	θ value	0.0330416 (rank : 744)
Query Neighborhood Hits	1243	Target Neighborhood Hits	347	Shared Neighborhood Hits	68
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

AB1IP_HUMAN
NC score	0.024280 (rank : 1330)	θ value	8.99809 (rank : 1187)
Query Neighborhood Hits	1243	Target Neighborhood Hits	213	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

PRR3_HUMAN
NC score	0.024277 (rank : 1331)	θ value	0.0736092 (rank : 769)
Query Neighborhood Hits	1243	Target Neighborhood Hits	46	Shared Neighborhood Hits	14
SwissProt Accessions	P79522, Q5RJB5	Gene names	PRR3, CAT56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

IRS2_HUMAN
NC score	0.024193 (rank : 1332)	θ value	8.99809 (rank : 1211)
Query Neighborhood Hits	1243	Target Neighborhood Hits	262	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

JADE2_MOUSE
NC score	0.024024 (rank : 1333)	θ value	0.0148317 (rank : 707)
Query Neighborhood Hits	1243	Target Neighborhood Hits	560	Shared Neighborhood Hits	149
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

DIAP1_HUMAN
NC score	0.023937 (rank : 1334)	θ value	0.0563607 (rank : 756)
Query Neighborhood Hits	1243	Target Neighborhood Hits	784	Shared Neighborhood Hits	128
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

SYNJ1_MOUSE
NC score	0.023822 (rank : 1335)	θ value	4.03905 (rank : 1084)
Query Neighborhood Hits	1243	Target Neighborhood Hits	516	Shared Neighborhood Hits	159
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

PELP1_HUMAN
NC score	0.023715 (rank : 1336)	θ value	0.62314 (rank : 896)
Query Neighborhood Hits	1243	Target Neighborhood Hits	596	Shared Neighborhood Hits	101
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

SMRC1_MOUSE
NC score	0.023624 (rank : 1337)	θ value	0.0330416 (rank : 742)
Query Neighborhood Hits	1243	Target Neighborhood Hits	459	Shared Neighborhood Hits	72
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

CSPG5_MOUSE
NC score	0.023497 (rank : 1338)	θ value	0.279714 (rank : 831)
Query Neighborhood Hits	1243	Target Neighborhood Hits	211	Shared Neighborhood Hits	64
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

SET1A_HUMAN
NC score	0.023329 (rank : 1339)	θ value	1.81305 (rank : 987)
Query Neighborhood Hits	1243	Target Neighborhood Hits	690	Shared Neighborhood Hits	130
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

ANR11_HUMAN
NC score	0.023315 (rank : 1340)	θ value	0.0330416 (rank : 737)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1289	Shared Neighborhood Hits	184
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

PPRB_MOUSE
NC score	0.023241 (rank : 1341)	θ value	0.62314 (rank : 897)
Query Neighborhood Hits	1243	Target Neighborhood Hits	354	Shared Neighborhood Hits	75
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

SMRC2_HUMAN
NC score	0.023191 (rank : 1342)	θ value	8.99809 (rank : 1236)
Query Neighborhood Hits	1243	Target Neighborhood Hits	499	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

FMNL_MOUSE
NC score	0.023051 (rank : 1343)	θ value	8.99809 (rank : 1205)
Query Neighborhood Hits	1243	Target Neighborhood Hits	428	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

ATX7_HUMAN
NC score	0.022985 (rank : 1344)	θ value	1.81305 (rank : 969)
Query Neighborhood Hits	1243	Target Neighborhood Hits	351	Shared Neighborhood Hits	115
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

GAK10_HUMAN
NC score	0.022806 (rank : 1345)	θ value	0.62314 (rank : 890)
Query Neighborhood Hits	1243	Target Neighborhood Hits	289	Shared Neighborhood Hits	107
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
NC score	0.022522 (rank : 1346)	θ value	1.06291 (rank : 933)
Query Neighborhood Hits	1243	Target Neighborhood Hits	374	Shared Neighborhood Hits	142
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

RANB9_HUMAN
NC score	0.022245 (rank : 1347)	θ value	0.0961366 (rank : 790)
Query Neighborhood Hits	1243	Target Neighborhood Hits	179	Shared Neighborhood Hits	64
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

PHLB1_HUMAN
NC score	0.022079 (rank : 1348)	θ value	1.38821 (rank : 962)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1038	Shared Neighborhood Hits	181
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PPRB_HUMAN
NC score	0.021955 (rank : 1349)	θ value	6.88961 (rank : 1168)
Query Neighborhood Hits	1243	Target Neighborhood Hits	311	Shared Neighborhood Hits	63
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

MUC13_MOUSE
NC score	0.021837 (rank : 1350)	θ value	8.99809 (rank : 1221)
Query Neighborhood Hits	1243	Target Neighborhood Hits	447	Shared Neighborhood Hits	75
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

SYN2_HUMAN
NC score	0.021781 (rank : 1351)	θ value	3.0926 (rank : 1056)
Query Neighborhood Hits	1243	Target Neighborhood Hits	213	Shared Neighborhood Hits	76
SwissProt Accessions	Q92777	Gene names	SYN2
Domain Architecture
Description	Synapsin-2 (Synapsin II).

BAZ2A_HUMAN
NC score	0.021660 (rank : 1352)	θ value	0.365318 (rank : 848)
Query Neighborhood Hits	1243	Target Neighborhood Hits	780	Shared Neighborhood Hits	162
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

SFR15_HUMAN
NC score	0.021622 (rank : 1353)	θ value	1.06291 (rank : 941)
Query Neighborhood Hits	1243	Target Neighborhood Hits	368	Shared Neighborhood Hits	87
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

RBM12_MOUSE
NC score	0.021468 (rank : 1354)	θ value	1.38821 (rank : 963)
Query Neighborhood Hits	1243	Target Neighborhood Hits	313	Shared Neighborhood Hits	85
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

PRG4_MOUSE
NC score	0.021456 (rank : 1355)	θ value	5.27518 (rank : 1113)
Query Neighborhood Hits	1243	Target Neighborhood Hits	624	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SCAR3_HUMAN
NC score	0.021301 (rank : 1356)	θ value	5.27518 (rank : 1120)
Query Neighborhood Hits	1243	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q6AZY7, Q9UM15, Q9UM16	Gene names	SCARA3, CSR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3 (Cellular stress response gene protein).

SMRC2_MOUSE
NC score	0.021278 (rank : 1357)	θ value	5.27518 (rank : 1125)
Query Neighborhood Hits	1243	Target Neighborhood Hits	487	Shared Neighborhood Hits	95
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

CAC1G_HUMAN
NC score	0.021136 (rank : 1358)	θ value	0.21417 (rank : 816)
Query Neighborhood Hits	1243	Target Neighborhood Hits	587	Shared Neighborhood Hits	185
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

IRS2_MOUSE
NC score	0.020543 (rank : 1359)	θ value	1.38821 (rank : 958)
Query Neighborhood Hits	1243	Target Neighborhood Hits	248	Shared Neighborhood Hits	73
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

EVL_HUMAN
NC score	0.020459 (rank : 1360)	θ value	6.88961 (rank : 1145)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

MYO15_HUMAN
NC score	0.020253 (rank : 1361)	θ value	1.06291 (rank : 937)
Query Neighborhood Hits	1243	Target Neighborhood Hits	671	Shared Neighborhood Hits	205
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MLL4_HUMAN
NC score	0.020242 (rank : 1362)	θ value	3.0926 (rank : 1045)
Query Neighborhood Hits	1243	Target Neighborhood Hits	722	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

SYN3_HUMAN
NC score	0.020168 (rank : 1363)	θ value	0.365318 (rank : 859)
Query Neighborhood Hits	1243	Target Neighborhood Hits	203	Shared Neighborhood Hits	63
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

IF4B_HUMAN
NC score	0.019946 (rank : 1364)	θ value	2.36792 (rank : 1008)
Query Neighborhood Hits	1243	Target Neighborhood Hits	417	Shared Neighborhood Hits	111
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

DYN1_HUMAN
NC score	0.019827 (rank : 1365)	θ value	0.0961366 (rank : 778)
Query Neighborhood Hits	1243	Target Neighborhood Hits	216	Shared Neighborhood Hits	72
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

SGIP1_HUMAN
NC score	0.019781 (rank : 1366)	θ value	5.27518 (rank : 1122)
Query Neighborhood Hits	1243	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

CG1_HUMAN
NC score	0.019717 (rank : 1367)	θ value	6.88961 (rank : 1139)
Query Neighborhood Hits	1243	Target Neighborhood Hits	222	Shared Neighborhood Hits	77
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

BRD8_MOUSE
NC score	0.019511 (rank : 1368)	θ value	0.813845 (rank : 903)
Query Neighborhood Hits	1243	Target Neighborhood Hits	422	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

EMID2_MOUSE
NC score	0.019266 (rank : 1369)	θ value	5.27518 (rank : 1101)
Query Neighborhood Hits	1243	Target Neighborhood Hits	201	Shared Neighborhood Hits	66
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

PGCA_MOUSE
NC score	0.019112 (rank : 1370)	θ value	0.00102713 (rank : 630)
Query Neighborhood Hits	1243	Target Neighborhood Hits	643	Shared Neighborhood Hits	98
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

LBXCO_HUMAN
NC score	0.018938 (rank : 1371)	θ value	0.0431538 (rank : 746)
Query Neighborhood Hits	1243	Target Neighborhood Hits	167	Shared Neighborhood Hits	42
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

DIAP1_MOUSE
NC score	0.018887 (rank : 1372)	θ value	2.36792 (rank : 999)
Query Neighborhood Hits	1243	Target Neighborhood Hits	839	Shared Neighborhood Hits	126
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

BRD4_MOUSE
NC score	0.018699 (rank : 1373)	θ value	1.81305 (rank : 970)
Query Neighborhood Hits	1243	Target Neighborhood Hits	845	Shared Neighborhood Hits	147
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

SYNJ1_HUMAN
NC score	0.018662 (rank : 1374)	θ value	5.27518 (rank : 1128)
Query Neighborhood Hits	1243	Target Neighborhood Hits	498	Shared Neighborhood Hits	145
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SF01_HUMAN
NC score	0.018642 (rank : 1375)	θ value	8.99809 (rank : 1232)
Query Neighborhood Hits	1243	Target Neighborhood Hits	287	Shared Neighborhood Hits	84
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

VASP_HUMAN
NC score	0.018607 (rank : 1376)	θ value	4.03905 (rank : 1089)
Query Neighborhood Hits	1243	Target Neighborhood Hits	201	Shared Neighborhood Hits	69
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

ZN598_HUMAN
NC score	0.018584 (rank : 1377)	θ value	0.21417 (rank : 828)
Query Neighborhood Hits	1243	Target Neighborhood Hits	339	Shared Neighborhood Hits	63
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

TM119_HUMAN
NC score	0.018446 (rank : 1378)	θ value	2.36792 (rank : 1018)
Query Neighborhood Hits	1243	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q4V9L6, Q6UXE5, Q8N2F5	Gene names	TMEM119
Domain Architecture	No domain graphic available
Description	Transmembrane protein 119 precursor.

MILK1_HUMAN
NC score	0.018393 (rank : 1379)	θ value	0.62314 (rank : 892)
Query Neighborhood Hits	1243	Target Neighborhood Hits	427	Shared Neighborhood Hits	99
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

DIAP2_MOUSE
NC score	0.018305 (rank : 1380)	θ value	3.0926 (rank : 1037)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	68
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

PRR11_MOUSE
NC score	0.018190 (rank : 1381)	θ value	0.0961366 (rank : 789)
Query Neighborhood Hits	1243	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BHE0, Q3V3H1	Gene names	Prr11
Domain Architecture	No domain graphic available
Description	Proline-rich protein 11.

K0460_HUMAN
NC score	0.018010 (rank : 1382)	θ value	0.47712 (rank : 870)
Query Neighborhood Hits	1243	Target Neighborhood Hits	357	Shared Neighborhood Hits	65
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

SGIP1_MOUSE
NC score	0.017818 (rank : 1383)	θ value	8.99809 (rank : 1234)
Query Neighborhood Hits	1243	Target Neighborhood Hits	180	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

ATG9A_HUMAN
NC score	0.017576 (rank : 1384)	θ value	0.125558 (rank : 796)
Query Neighborhood Hits	1243	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z3C6, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7	Gene names	ATG9A, APG9L1
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 9A (APG9-like 1).

SFR14_MOUSE
NC score	0.017433 (rank : 1385)	θ value	0.163984 (rank : 814)
Query Neighborhood Hits	1243	Target Neighborhood Hits	238	Shared Neighborhood Hits	61
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

RIN3_HUMAN
NC score	0.017366 (rank : 1386)	θ value	5.27518 (rank : 1117)
Query Neighborhood Hits	1243	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

ATX2_HUMAN
NC score	0.017128 (rank : 1387)	θ value	0.365318 (rank : 847)
Query Neighborhood Hits	1243	Target Neighborhood Hits	375	Shared Neighborhood Hits	80
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

TROAP_HUMAN
NC score	0.017051 (rank : 1388)	θ value	6.88961 (rank : 1183)
Query Neighborhood Hits	1243	Target Neighborhood Hits	258	Shared Neighborhood Hits	87
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

SF01_MOUSE
NC score	0.016853 (rank : 1389)	θ value	8.99809 (rank : 1233)
Query Neighborhood Hits	1243	Target Neighborhood Hits	240	Shared Neighborhood Hits	69
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

DYN1_MOUSE
NC score	0.016852 (rank : 1390)	θ value	0.0961366 (rank : 779)
Query Neighborhood Hits	1243	Target Neighborhood Hits	168	Shared Neighborhood Hits	52
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DREB_MOUSE
NC score	0.016852 (rank : 1391)	θ value	4.03905 (rank : 1067)
Query Neighborhood Hits	1243	Target Neighborhood Hits	446	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

TCRG1_MOUSE
NC score	0.016448 (rank : 1392)	θ value	8.99809 (rank : 1242)
Query Neighborhood Hits	1243	Target Neighborhood Hits	947	Shared Neighborhood Hits	123
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

MUC2_HUMAN
NC score	0.016399 (rank : 1393)	θ value	5.27518 (rank : 1109)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	141
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SF3B2_HUMAN
NC score	0.016237 (rank : 1394)	θ value	5.27518 (rank : 1121)
Query Neighborhood Hits	1243	Target Neighborhood Hits	157	Shared Neighborhood Hits	30
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

BRD4_HUMAN
NC score	0.016208 (rank : 1395)	θ value	8.99809 (rank : 1195)
Query Neighborhood Hits	1243	Target Neighborhood Hits	851	Shared Neighborhood Hits	152
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

EPN3_HUMAN
NC score	0.015989 (rank : 1396)	θ value	1.06291 (rank : 931)
Query Neighborhood Hits	1243	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

CNOT4_MOUSE
NC score	0.015924 (rank : 1397)	θ value	0.62314 (rank : 887)
Query Neighborhood Hits	1243	Target Neighborhood Hits	277	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

DIAP3_MOUSE
NC score	0.015895 (rank : 1398)	θ value	0.813845 (rank : 910)
Query Neighborhood Hits	1243	Target Neighborhood Hits	221	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z207	Gene names	Diaph3, Diap3
Domain Architecture
Description	Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2).

GAK8_HUMAN
NC score	0.015714 (rank : 1399)	θ value	0.813845 (rank : 918)
Query Neighborhood Hits	1243	Target Neighborhood Hits	145	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

DIAP2_HUMAN
NC score	0.015648 (rank : 1400)	θ value	6.88961 (rank : 1143)
Query Neighborhood Hits	1243	Target Neighborhood Hits	342	Shared Neighborhood Hits	67
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

REXO1_HUMAN
NC score	0.015533 (rank : 1401)	θ value	0.813845 (rank : 924)
Query Neighborhood Hits	1243	Target Neighborhood Hits	242	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

TRI66_MOUSE
NC score	0.015335 (rank : 1402)	θ value	1.38821 (rank : 965)
Query Neighborhood Hits	1243	Target Neighborhood Hits	491	Shared Neighborhood Hits	100
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

DAAM1_HUMAN
NC score	0.015284 (rank : 1403)	θ value	1.81305 (rank : 972)
Query Neighborhood Hits	1243	Target Neighborhood Hits	483	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

NPHP4_MOUSE
NC score	0.015205 (rank : 1404)	θ value	0.21417 (rank : 822)
Query Neighborhood Hits	1243	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	P59240	Gene names	Nphp4
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

CP007_MOUSE
NC score	0.015072 (rank : 1405)	θ value	4.03905 (rank : 1063)
Query Neighborhood Hits	1243	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

NFAC1_HUMAN
NC score	0.014995 (rank : 1406)	θ value	0.0961366 (rank : 784)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	91
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

TM16H_HUMAN
NC score	0.014877 (rank : 1407)	θ value	0.47712 (rank : 880)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

PP1RA_MOUSE
NC score	0.014833 (rank : 1408)	θ value	4.03905 (rank : 1079)
Query Neighborhood Hits	1243	Target Neighborhood Hits	175	Shared Neighborhood Hits	50
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

EPN1_MOUSE
NC score	0.014817 (rank : 1409)	θ value	5.27518 (rank : 1102)
Query Neighborhood Hits	1243	Target Neighborhood Hits	240	Shared Neighborhood Hits	78
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

PCX3_MOUSE
NC score	0.014805 (rank : 1410)	θ value	3.0926 (rank : 1048)
Query Neighborhood Hits	1243	Target Neighborhood Hits	134	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

DAAM1_MOUSE
NC score	0.014546 (rank : 1411)	θ value	1.81305 (rank : 973)
Query Neighborhood Hits	1243	Target Neighborhood Hits	443	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BPM0, Q80Y68, Q9CQQ2	Gene names	Daam1
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

3BP1_HUMAN
NC score	0.014423 (rank : 1412)	θ value	0.47712 (rank : 861)
Query Neighborhood Hits	1243	Target Neighborhood Hits	376	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MY18B_HUMAN
NC score	0.014375 (rank : 1413)	θ value	6.88961 (rank : 1158)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1299	Shared Neighborhood Hits	179
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

GTSE1_MOUSE
NC score	0.014195 (rank : 1414)	θ value	8.99809 (rank : 1208)
Query Neighborhood Hits	1243	Target Neighborhood Hits	245	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

LR37A_HUMAN
NC score	0.014102 (rank : 1415)	θ value	0.813845 (rank : 921)
Query Neighborhood Hits	1243	Target Neighborhood Hits	720	Shared Neighborhood Hits	129
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

NUP53_MOUSE
NC score	0.013884 (rank : 1416)	θ value	3.0926 (rank : 1047)
Query Neighborhood Hits	1243	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

CDC27_HUMAN
NC score	0.013807 (rank : 1417)	θ value	0.00509761 (rank : 677)
Query Neighborhood Hits	1243	Target Neighborhood Hits	139	Shared Neighborhood Hits	12
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

CITE4_MOUSE
NC score	0.013767 (rank : 1418)	θ value	3.0926 (rank : 1030)
Query Neighborhood Hits	1243	Target Neighborhood Hits	73	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WUL8, Q66JX0, Q8R176, Q9CZV4	Gene names	Cited4, Mrg2
Domain Architecture	No domain graphic available
Description	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG- 2).

AUXI_HUMAN
NC score	0.013732 (rank : 1419)	θ value	8.99809 (rank : 1192)
Query Neighborhood Hits	1243	Target Neighborhood Hits	99	Shared Neighborhood Hits	10
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

PRR3_MOUSE
NC score	0.013529 (rank : 1420)	θ value	5.27518 (rank : 1114)
Query Neighborhood Hits	1243	Target Neighborhood Hits	39	Shared Neighborhood Hits	11
SwissProt Accessions	Q811B5, Q91YI5	Gene names	Prr3, Cat56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

HCN4_MOUSE
NC score	0.013492 (rank : 1421)	θ value	2.36792 (rank : 1004)
Query Neighborhood Hits	1243	Target Neighborhood Hits	284	Shared Neighborhood Hits	89
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

LDB3_MOUSE
NC score	0.013315 (rank : 1422)	θ value	0.62314 (rank : 891)
Query Neighborhood Hits	1243	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

HCN2_HUMAN
NC score	0.012605 (rank : 1423)	θ value	1.38821 (rank : 957)
Query Neighborhood Hits	1243	Target Neighborhood Hits	369	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

RFX1_HUMAN
NC score	0.012593 (rank : 1424)	θ value	8.99809 (rank : 1231)
Query Neighborhood Hits	1243	Target Neighborhood Hits	256	Shared Neighborhood Hits	78
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

TRI66_HUMAN
NC score	0.012536 (rank : 1425)	θ value	0.279714 (rank : 842)
Query Neighborhood Hits	1243	Target Neighborhood Hits	479	Shared Neighborhood Hits	94
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

CT055_HUMAN
NC score	0.012151 (rank : 1426)	θ value	1.38821 (rank : 952)
Query Neighborhood Hits	1243	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ89	Gene names	C20orf55
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55.

GNAS1_HUMAN
NC score	0.011868 (rank : 1427)	θ value	0.0961366 (rank : 780)
Query Neighborhood Hits	1243	Target Neighborhood Hits	278	Shared Neighborhood Hits	80
SwissProt Accessions	Q5JWF2, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

LARP4_MOUSE
NC score	0.011847 (rank : 1428)	θ value	8.99809 (rank : 1217)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

PHLB1_MOUSE
NC score	0.011827 (rank : 1429)	θ value	1.06291 (rank : 939)
Query Neighborhood Hits	1243	Target Neighborhood Hits	678	Shared Neighborhood Hits	99
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

AIM1_HUMAN
NC score	0.011647 (rank : 1430)	θ value	0.365318 (rank : 843)
Query Neighborhood Hits	1243	Target Neighborhood Hits	247	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

ZN318_MOUSE
NC score	0.011605 (rank : 1431)	θ value	4.03905 (rank : 1090)
Query Neighborhood Hits	1243	Target Neighborhood Hits	642	Shared Neighborhood Hits	80
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

MEF2B_HUMAN
NC score	0.011546 (rank : 1432)	θ value	4.03905 (rank : 1075)
Query Neighborhood Hits	1243	Target Neighborhood Hits	150	Shared Neighborhood Hits	65
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

NCOA2_MOUSE
NC score	0.011395 (rank : 1433)	θ value	2.36792 (rank : 1012)
Query Neighborhood Hits	1243	Target Neighborhood Hits	281	Shared Neighborhood Hits	93
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

GCFC_HUMAN
NC score	0.011346 (rank : 1434)	θ value	0.813845 (rank : 919)
Query Neighborhood Hits	1243	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5B6, Q9NYQ0	Gene names	GCFC, C21orf66
Domain Architecture	No domain graphic available
Description	GC-rich sequence DNA-binding factor homolog.

CUTL2_HUMAN
NC score	0.011281 (rank : 1435)	θ value	2.36792 (rank : 998)
Query Neighborhood Hits	1243	Target Neighborhood Hits	906	Shared Neighborhood Hits	137
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

ZN318_HUMAN
NC score	0.011116 (rank : 1436)	θ value	2.36792 (rank : 1021)
Query Neighborhood Hits	1243	Target Neighborhood Hits	497	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

HCN4_HUMAN
NC score	0.011104 (rank : 1437)	θ value	8.99809 (rank : 1209)
Query Neighborhood Hits	1243	Target Neighborhood Hits	303	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

NCOR1_MOUSE
NC score	0.011050 (rank : 1438)	θ value	4.03905 (rank : 1077)
Query Neighborhood Hits	1243	Target Neighborhood Hits	521	Shared Neighborhood Hits	77
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

CABL2_HUMAN
NC score	0.011046 (rank : 1439)	θ value	3.0926 (rank : 1027)
Query Neighborhood Hits	1243	Target Neighborhood Hits	84	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

MAML1_HUMAN
NC score	0.010990 (rank : 1440)	θ value	6.88961 (rank : 1156)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

PSMF1_MOUSE
NC score	0.010959 (rank : 1441)	θ value	5.27518 (rank : 1115)
Query Neighborhood Hits	1243	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHL8, Q8C0G9	Gene names	Psmf1
Domain Architecture	No domain graphic available
Description	Proteasome inhibitor PI31 subunit.

GORS2_MOUSE
NC score	0.010871 (rank : 1442)	θ value	1.06291 (rank : 934)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

MICA1_HUMAN
NC score	0.010355 (rank : 1443)	θ value	1.06291 (rank : 936)
Query Neighborhood Hits	1243	Target Neighborhood Hits	279	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

ANR25_MOUSE
NC score	0.010146 (rank : 1444)	θ value	4.03905 (rank : 1058)
Query Neighborhood Hits	1243	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

X3CL1_HUMAN
NC score	0.010032 (rank : 1445)	θ value	1.81305 (rank : 990)
Query Neighborhood Hits	1243	Target Neighborhood Hits	152	Shared Neighborhood Hits	38
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

WDR33_HUMAN
NC score	0.009996 (rank : 1446)	θ value	0.00228821 (rank : 649)
Query Neighborhood Hits	1243	Target Neighborhood Hits	638	Shared Neighborhood Hits	115
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

ASXL1_HUMAN
NC score	0.009880 (rank : 1447)	θ value	3.0926 (rank : 1025)
Query Neighborhood Hits	1243	Target Neighborhood Hits	260	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

PTN23_MOUSE
NC score	0.009875 (rank : 1448)	θ value	0.21417 (rank : 825)
Query Neighborhood Hits	1243	Target Neighborhood Hits	726	Shared Neighborhood Hits	142
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

DAB2_MOUSE
NC score	0.009848 (rank : 1449)	θ value	4.03905 (rank : 1066)
Query Neighborhood Hits	1243	Target Neighborhood Hits	163	Shared Neighborhood Hits	47
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

CNOT4_HUMAN
NC score	0.009760 (rank : 1450)	θ value	5.27518 (rank : 1095)
Query Neighborhood Hits	1243	Target Neighborhood Hits	207	Shared Neighborhood Hits	45
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

DYN2_MOUSE
NC score	0.009534 (rank : 1451)	θ value	2.36792 (rank : 1001)
Query Neighborhood Hits	1243	Target Neighborhood Hits	104	Shared Neighborhood Hits	24
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

PTN23_HUMAN
NC score	0.009497 (rank : 1452)	θ value	0.62314 (rank : 898)
Query Neighborhood Hits	1243	Target Neighborhood Hits	646	Shared Neighborhood Hits	106
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

ANR47_HUMAN
NC score	0.009187 (rank : 1453)	θ value	3.0926 (rank : 1024)
Query Neighborhood Hits	1243	Target Neighborhood Hits	369	Shared Neighborhood Hits	42
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

SETBP_HUMAN
NC score	0.008988 (rank : 1454)	θ value	6.88961 (rank : 1172)
Query Neighborhood Hits	1243	Target Neighborhood Hits	305	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SPR2D_MOUSE
NC score	0.008915 (rank : 1455)	θ value	8.99809 (rank : 1239)
Query Neighborhood Hits	1243	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

ZC3H3_MOUSE
NC score	0.008910 (rank : 1456)	θ value	1.38821 (rank : 967)
Query Neighborhood Hits	1243	Target Neighborhood Hits	188	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

RFIP3_HUMAN
NC score	0.008905 (rank : 1457)	θ value	6.88961 (rank : 1169)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1055	Shared Neighborhood Hits	119
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

IF39_MOUSE
NC score	0.008872 (rank : 1458)	θ value	3.0926 (rank : 1041)
Query Neighborhood Hits	1243	Target Neighborhood Hits	206	Shared Neighborhood Hits	40
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

RSMB_HUMAN
NC score	0.008729 (rank : 1459)	θ value	5.27518 (rank : 1118)
Query Neighborhood Hits	1243	Target Neighborhood Hits	117	Shared Neighborhood Hits	38
SwissProt Accessions	P14678, Q15490, Q9UIS5	Gene names	SNRPB, COD, SNRPB1
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/Sm-B') (SmB/SmB').

EP400_HUMAN
NC score	0.008709 (rank : 1460)	θ value	2.36792 (rank : 1002)
Query Neighborhood Hits	1243	Target Neighborhood Hits	556	Shared Neighborhood Hits	109
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

SNX19_HUMAN
NC score	0.008631 (rank : 1461)	θ value	4.03905 (rank : 1083)
Query Neighborhood Hits	1243	Target Neighborhood Hits	123	Shared Neighborhood Hits	28
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

SYNG_MOUSE
NC score	0.008236 (rank : 1462)	θ value	6.88961 (rank : 1178)
Query Neighborhood Hits	1243	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

MCM4_MOUSE
NC score	0.008082 (rank : 1463)	θ value	0.00869519 (rank : 690)
Query Neighborhood Hits	1243	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	P49717, O89056	Gene names	Mcm4, Cdc21, Mcmd4
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

PRR6_HUMAN
NC score	0.008018 (rank : 1464)	θ value	8.99809 (rank : 1228)
Query Neighborhood Hits	1243	Target Neighborhood Hits	39	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z7K6, Q3L8N5, Q8NFH6	Gene names	PRR6
Domain Architecture	No domain graphic available
Description	Proline-rich protein 6 (Nuclear protein p30).

SMCA4_HUMAN
NC score	0.007964 (rank : 1465)	θ value	6.88961 (rank : 1173)
Query Neighborhood Hits	1243	Target Neighborhood Hits	597	Shared Neighborhood Hits	131
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

CAC1H_HUMAN
NC score	0.007897 (rank : 1466)	θ value	3.0926 (rank : 1028)
Query Neighborhood Hits	1243	Target Neighborhood Hits	307	Shared Neighborhood Hits	86
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

EWS_HUMAN
NC score	0.007737 (rank : 1467)	θ value	8.99809 (rank : 1204)
Query Neighborhood Hits	1243	Target Neighborhood Hits	249	Shared Neighborhood Hits	50
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

FYB_MOUSE
NC score	0.007718 (rank : 1468)	θ value	8.99809 (rank : 1206)
Query Neighborhood Hits	1243	Target Neighborhood Hits	194	Shared Neighborhood Hits	39
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

IQEC3_MOUSE
NC score	0.007475 (rank : 1469)	θ value	4.03905 (rank : 1070)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	79
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

LZTS2_HUMAN
NC score	0.007348 (rank : 1470)	θ value	3.0926 (rank : 1043)
Query Neighborhood Hits	1243	Target Neighborhood Hits	427	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

TNR8_MOUSE
NC score	0.007268 (rank : 1471)	θ value	6.88961 (rank : 1182)
Query Neighborhood Hits	1243	Target Neighborhood Hits	208	Shared Neighborhood Hits	35
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

SF3B4_HUMAN
NC score	0.007154 (rank : 1472)	θ value	1.81305 (rank : 988)
Query Neighborhood Hits	1243	Target Neighborhood Hits	445	Shared Neighborhood Hits	91
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

MAGC1_HUMAN
NC score	0.006991 (rank : 1473)	θ value	4.03905 (rank : 1074)
Query Neighborhood Hits	1243	Target Neighborhood Hits	431	Shared Neighborhood Hits	98
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MAGD4_HUMAN
NC score	0.006961 (rank : 1474)	θ value	0.813845 (rank : 922)
Query Neighborhood Hits	1243	Target Neighborhood Hits	338	Shared Neighborhood Hits	94
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

P73L_HUMAN
NC score	0.006894 (rank : 1475)	θ value	5.27518 (rank : 1110)
Query Neighborhood Hits	1243	Target Neighborhood Hits	102	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74	Gene names	TP73L, KET, P63, P73H, P73L
Domain Architecture	No domain graphic available
Description	Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).

CABL2_MOUSE
NC score	0.006866 (rank : 1476)	θ value	6.88961 (rank : 1138)
Query Neighborhood Hits	1243	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

PSD4_HUMAN
NC score	0.006778 (rank : 1477)	θ value	3.0926 (rank : 1051)
Query Neighborhood Hits	1243	Target Neighborhood Hits	178	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CDT1_MOUSE
NC score	0.006551 (rank : 1478)	θ value	8.99809 (rank : 1196)
Query Neighborhood Hits	1243	Target Neighborhood Hits	72	Shared Neighborhood Hits	21
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

MNAB_MOUSE
NC score	0.006469 (rank : 1479)	θ value	2.36792 (rank : 1011)
Query Neighborhood Hits	1243	Target Neighborhood Hits	231	Shared Neighborhood Hits	39
SwissProt Accessions	P0C090	Gene names	Mnab
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein.

EWS_MOUSE
NC score	0.006403 (rank : 1480)	θ value	6.88961 (rank : 1146)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

CENG1_HUMAN
NC score	0.006274 (rank : 1481)	θ value	1.06291 (rank : 929)
Query Neighborhood Hits	1243	Target Neighborhood Hits	544	Shared Neighborhood Hits	69
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CLSPN_MOUSE
NC score	0.006252 (rank : 1482)	θ value	2.36792 (rank : 994)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	34
SwissProt Accessions	Q80YR7, Q69GM2	Gene names	Clspn
Domain Architecture	No domain graphic available
Description	Claspin.

CSTFT_MOUSE
NC score	0.006135 (rank : 1483)	θ value	0.47712 (rank : 865)
Query Neighborhood Hits	1243	Target Neighborhood Hits	356	Shared Neighborhood Hits	82
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

PGRP2_HUMAN
NC score	0.006110 (rank : 1484)	θ value	1.38821 (rank : 961)
Query Neighborhood Hits	1243	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PD5, Q96N74, Q9UC60	Gene names	PGLYRP2, PGLYRPL, PGRPL
Domain Architecture
Description	N-acetylmuramoyl-L-alanine amidase precursor (EC 3.5.1.28) (Peptidoglycan recognition protein long) (PGRP-L) (Peptidoglycan recognition protein 2).

MUCDL_MOUSE
NC score	0.006063 (rank : 1485)	θ value	6.88961 (rank : 1157)
Query Neighborhood Hits	1243	Target Neighborhood Hits	461	Shared Neighborhood Hits	100
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

IL32_HUMAN
NC score	0.005964 (rank : 1486)	θ value	6.88961 (rank : 1149)
Query Neighborhood Hits	1243	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P24001, Q96GK9	Gene names	IL32, NK4
Domain Architecture	No domain graphic available
Description	Interleukin-32 precursor (IL-32) (Natural killer cells protein 4).

CSPG3_HUMAN
NC score	0.005818 (rank : 1487)	θ value	0.47712 (rank : 864)
Query Neighborhood Hits	1243	Target Neighborhood Hits	676	Shared Neighborhood Hits	88
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

BORG3_HUMAN
NC score	0.005814 (rank : 1488)	θ value	3.0926 (rank : 1026)
Query Neighborhood Hits	1243	Target Neighborhood Hits	36	Shared Neighborhood Hits	10
SwissProt Accessions	Q6NZY7, Q8TB51	Gene names	CDC42EP5, BORG3, CEP5
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 5 (Binder of Rho GTPases 3).

TBX21_HUMAN
NC score	0.005635 (rank : 1489)	θ value	1.06291 (rank : 942)
Query Neighborhood Hits	1243	Target Neighborhood Hits	146	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

FOXC1_MOUSE
NC score	0.005426 (rank : 1490)	θ value	0.0736092 (rank : 765)
Query Neighborhood Hits	1243	Target Neighborhood Hits	218	Shared Neighborhood Hits	55
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

T2FA_HUMAN
NC score	0.005250 (rank : 1491)	θ value	6.88961 (rank : 1180)
Query Neighborhood Hits	1243	Target Neighborhood Hits	228	Shared Neighborhood Hits	26
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

CT128_HUMAN
NC score	0.005242 (rank : 1492)	θ value	6.88961 (rank : 1142)
Query Neighborhood Hits	1243	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQN1, Q5JWN6, Q8N276	Gene names	C20orf128
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf128.

CING_HUMAN
NC score	0.005219 (rank : 1493)	θ value	1.38821 (rank : 948)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1275	Shared Neighborhood Hits	111
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

PKNX1_HUMAN
NC score	0.005179 (rank : 1494)	θ value	0.21417 (rank : 823)
Query Neighborhood Hits	1243	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	P55347, O00528, Q8IWT7	Gene names	PKNOX1, PREP1
Domain Architecture
Description	Homeobox protein PKNOX1 (PBX/knotted homeobox 1) (Homeobox protein PREP-1).

NIBL_HUMAN
NC score	0.005171 (rank : 1495)	θ value	8.99809 (rank : 1223)
Query Neighborhood Hits	1243	Target Neighborhood Hits	61	Shared Neighborhood Hits	18
SwissProt Accessions	Q96TA1, Q9BUS2, Q9NT35	Gene names	C9orf88
Domain Architecture	No domain graphic available
Description	Niban-like protein (Meg-3).

PKNX1_MOUSE
NC score	0.005139 (rank : 1496)	θ value	0.21417 (rank : 824)
Query Neighborhood Hits	1243	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	O70477	Gene names	Pknox1
Domain Architecture
Description	Homeobox protein PKNOX1 (PBX/knotted homeobox 1).

CHKA_HUMAN
NC score	0.005041 (rank : 1497)	θ value	1.38821 (rank : 946)
Query Neighborhood Hits	1243	Target Neighborhood Hits	25	Shared Neighborhood Hits	7
SwissProt Accessions	P35790, Q8NE29	Gene names	CHKA, CHK, CKI
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

TIF1B_HUMAN
NC score	0.004989 (rank : 1498)	θ value	4.03905 (rank : 1087)
Query Neighborhood Hits	1243	Target Neighborhood Hits	312	Shared Neighborhood Hits	43
SwissProt Accessions	Q13263, O00677, Q7Z632, Q93040, Q96IM1	Gene names	TRIM28, KAP1, RNF96, TIF1B
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (RING finger protein 96).

NCOA2_HUMAN
NC score	0.004938 (rank : 1499)	θ value	6.88961 (rank : 1159)
Query Neighborhood Hits	1243	Target Neighborhood Hits	281	Shared Neighborhood Hits	69
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

CLIC6_MOUSE
NC score	0.004938 (rank : 1500)	θ value	5.27518 (rank : 1094)
Query Neighborhood Hits	1243	Target Neighborhood Hits	134	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

HCN3_MOUSE
NC score	0.004896 (rank : 1501)	θ value	3.0926 (rank : 1040)
Query Neighborhood Hits	1243	Target Neighborhood Hits	112	Shared Neighborhood Hits	35
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

FOXJ2_HUMAN
NC score	0.004855 (rank : 1502)	θ value	0.21417 (rank : 818)
Query Neighborhood Hits	1243	Target Neighborhood Hits	239	Shared Neighborhood Hits	53
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

TBX4_HUMAN
NC score	0.004807 (rank : 1503)	θ value	0.0736092 (rank : 771)
Query Neighborhood Hits	1243	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P57082	Gene names	TBX4
Domain Architecture
Description	T-box transcription factor TBX4 (T-box protein 4).

TACC1_MOUSE
NC score	0.004772 (rank : 1504)	θ value	2.36792 (rank : 1017)
Query Neighborhood Hits	1243	Target Neighborhood Hits	667	Shared Neighborhood Hits	67
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

A4_HUMAN
NC score	0.004707 (rank : 1505)	θ value	8.99809 (rank : 1186)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	31
SwissProt Accessions	P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q9BT38, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58	Gene names	APP, A4, AD1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) [Contains: Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)); Gamma-CTF(57) (Gamma- secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

OSBL5_HUMAN
NC score	0.004575 (rank : 1506)	θ value	1.38821 (rank : 960)
Query Neighborhood Hits	1243	Target Neighborhood Hits	117	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

TREF1_MOUSE
NC score	0.004433 (rank : 1507)	θ value	1.38821 (rank : 964)
Query Neighborhood Hits	1243	Target Neighborhood Hits	682	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

CD5_MOUSE
NC score	0.004375 (rank : 1508)	θ value	1.81305 (rank : 971)
Query Neighborhood Hits	1243	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P13379	Gene names	Cd5, Ly-1
Domain Architecture
Description	T-cell surface glycoprotein CD5 precursor (Lymphocyte antigen Ly-1) (Lyt-1).

FOXP4_MOUSE
NC score	0.004290 (rank : 1509)	θ value	0.0563607 (rank : 759)
Query Neighborhood Hits	1243	Target Neighborhood Hits	211	Shared Neighborhood Hits	35
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

DUS8_HUMAN
NC score	0.004290 (rank : 1510)	θ value	8.99809 (rank : 1201)
Query Neighborhood Hits	1243	Target Neighborhood Hits	161	Shared Neighborhood Hits	42
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

TREF1_HUMAN
NC score	0.004138 (rank : 1511)	θ value	0.0961366 (rank : 795)
Query Neighborhood Hits	1243	Target Neighborhood Hits	651	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PN7, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9	Gene names	TRERF1, RAPA, TREP132
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132) (Zinc finger protein rapa).

FOXC1_HUMAN
NC score	0.003932 (rank : 1512)	θ value	0.47712 (rank : 868)
Query Neighborhood Hits	1243	Target Neighborhood Hits	208	Shared Neighborhood Hits	51
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

MNAB_HUMAN
NC score	0.003813 (rank : 1513)	θ value	3.0926 (rank : 1046)
Query Neighborhood Hits	1243	Target Neighborhood Hits	196	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

STRC_MOUSE
NC score	0.003667 (rank : 1514)	θ value	8.99809 (rank : 1240)
Query Neighborhood Hits	1243	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	Q8VIM6	Gene names	Strc
Domain Architecture	No domain graphic available
Description	Stereocilin precursor.

SIT1_HUMAN
NC score	0.003614 (rank : 1515)	θ value	8.99809 (rank : 1235)
Query Neighborhood Hits	1243	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3P8	Gene names	SIT1, SIT
Domain Architecture	No domain graphic available
Description	Signaling threshold-regulating transmembrane adapter 1 precursor (Suppression-inducing transmembrane adapter 1) (SHP2-interacting transmembrane adapter protein) (gp30/40).

NOS3_MOUSE
NC score	0.003470 (rank : 1516)	θ value	6.88961 (rank : 1161)
Query Neighborhood Hits	1243	Target Neighborhood Hits	63	Shared Neighborhood Hits	23
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

LRP3_HUMAN
NC score	0.003413 (rank : 1517)	θ value	0.125558 (rank : 800)
Query Neighborhood Hits	1243	Target Neighborhood Hits	280	Shared Neighborhood Hits	43
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

NJMU_HUMAN
NC score	0.003231 (rank : 1518)	θ value	6.88961 (rank : 1160)
Query Neighborhood Hits	1243	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HAS0, Q7Z2H4	Gene names	C17orf75
Domain Architecture	No domain graphic available
Description	Protein Njmu-R1.

TBX21_MOUSE
NC score	0.003143 (rank : 1519)	θ value	8.99809 (rank : 1241)
Query Neighborhood Hits	1243	Target Neighborhood Hits	116	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

AKP8L_MOUSE
NC score	0.003080 (rank : 1520)	θ value	3.0926 (rank : 1023)
Query Neighborhood Hits	1243	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R0L7	Gene names	Akap8l, Nakap95
Domain Architecture
Description	A-kinase anchor protein 8-like (AKAP8-like protein) (Neighbor of A- kinase-anchoring protein 95) (Neighbor of AKAP95).

RKHD1_HUMAN
NC score	0.002873 (rank : 1521)	θ value	6.88961 (rank : 1170)
Query Neighborhood Hits	1243	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

BRD2_HUMAN
NC score	0.002712 (rank : 1522)	θ value	8.99809 (rank : 1194)
Query Neighborhood Hits	1243	Target Neighborhood Hits	242	Shared Neighborhood Hits	31
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

FOXJ2_MOUSE
NC score	0.002653 (rank : 1523)	θ value	1.06291 (rank : 932)
Query Neighborhood Hits	1243	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ES18	Gene names	Foxj2, Fhx
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

DVL2_HUMAN
NC score	0.002628 (rank : 1524)	θ value	0.47712 (rank : 866)
Query Neighborhood Hits	1243	Target Neighborhood Hits	223	Shared Neighborhood Hits	36
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

LAX1_MOUSE
NC score	0.002584 (rank : 1525)	θ value	8.99809 (rank : 1218)
Query Neighborhood Hits	1243	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHB3, Q8BS18, Q8CGV1	Gene names	Lax1, Lax
Domain Architecture	No domain graphic available
Description	Lymphocyte transmembrane adapter 1 (Membrane-associated adapter protein LAX) (Linker for activation of X cells).

ADDA_HUMAN
NC score	0.002445 (rank : 1526)	θ value	8.99809 (rank : 1188)
Query Neighborhood Hits	1243	Target Neighborhood Hits	108	Shared Neighborhood Hits	22
SwissProt Accessions	P35611, Q13734, Q14729, Q16156, Q9UJB6	Gene names	ADD1, ADDA
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

SYW_HUMAN
NC score	0.002338 (rank : 1527)	θ value	6.88961 (rank : 1179)
Query Neighborhood Hits	1243	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P23381, P78535, Q9UDL3	Gene names	WARS, WRS
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) (IFP53) (hWRS).

NASP_HUMAN
NC score	0.002292 (rank : 1528)	θ value	8.99809 (rank : 1222)
Query Neighborhood Hits	1243	Target Neighborhood Hits	709	Shared Neighborhood Hits	68
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

TBX4_MOUSE
NC score	0.002182 (rank : 1529)	θ value	4.03905 (rank : 1086)
Query Neighborhood Hits	1243	Target Neighborhood Hits	68	Shared Neighborhood Hits	13
SwissProt Accessions	P70325, Q8R5F6	Gene names	Tbx4
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX4 (T-box protein 4).

K0406_MOUSE
NC score	0.002172 (rank : 1530)	θ value	8.99809 (rank : 1212)
Query Neighborhood Hits	1243	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

RBM22_HUMAN
NC score	0.002000 (rank : 1531)	θ value	8.99809 (rank : 1229)
Query Neighborhood Hits	1243	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NW64, O95607	Gene names	RBM22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RBM22_MOUSE
NC score	0.002000 (rank : 1532)	θ value	8.99809 (rank : 1230)
Query Neighborhood Hits	1243	Target Neighborhood Hits	189	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BHS3, Q3TJB0, Q9CXA0	Gene names	Rbm22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

ANX11_MOUSE
NC score	0.001999 (rank : 1533)	θ value	4.03905 (rank : 1059)
Query Neighborhood Hits	1243	Target Neighborhood Hits	200	Shared Neighborhood Hits	61
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

DUS8_MOUSE
NC score	0.001898 (rank : 1534)	θ value	1.81305 (rank : 975)
Query Neighborhood Hits	1243	Target Neighborhood Hits	119	Shared Neighborhood Hits	19
SwissProt Accessions	O09112	Gene names	Dusp8, Nttp1
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Neuronal tyrosine threonine phosphatase 1).

UBP31_HUMAN
NC score	0.001882 (rank : 1535)	θ value	4.03905 (rank : 1088)
Query Neighborhood Hits	1243	Target Neighborhood Hits	293	Shared Neighborhood Hits	40
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

TBX1_MOUSE
NC score	0.001795 (rank : 1536)	θ value	4.03905 (rank : 1085)
Query Neighborhood Hits	1243	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	P70323, Q60706, Q99MP0, Q99P22	Gene names	Tbx1
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T- box protein).

CUTL2_MOUSE
NC score	0.001787 (rank : 1537)	θ value	8.99809 (rank : 1199)
Query Neighborhood Hits	1243	Target Neighborhood Hits	771	Shared Neighborhood Hits	83
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

PABP2_HUMAN
NC score	0.001776 (rank : 1538)	θ value	2.36792 (rank : 1013)
Query Neighborhood Hits	1243	Target Neighborhood Hits	212	Shared Neighborhood Hits	26
SwissProt Accessions	Q86U42, O43484	Gene names	PABPN1, PAB2, PABP2
Domain Architecture
Description	Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (Poly(A)- binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Nuclear poly(A)-binding protein 1).

DLL3_MOUSE
NC score	0.001742 (rank : 1539)	θ value	2.36792 (rank : 1000)
Query Neighborhood Hits	1243	Target Neighborhood Hits	399	Shared Neighborhood Hits	19
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

MOT8_HUMAN
NC score	0.001677 (rank : 1540)	θ value	5.27518 (rank : 1108)
Query Neighborhood Hits	1243	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	P36021, Q7Z797	Gene names	SLC16A2, MCT8, XPCT
Domain Architecture	No domain graphic available
Description	Monocarboxylate transporter 8 (MCT 8) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter).

PER2_HUMAN
NC score	0.001660 (rank : 1541)	θ value	6.88961 (rank : 1164)
Query Neighborhood Hits	1243	Target Neighborhood Hits	170	Shared Neighborhood Hits	37
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

MYST3_MOUSE
NC score	0.001521 (rank : 1542)	θ value	4.03905 (rank : 1076)
Query Neighborhood Hits	1243	Target Neighborhood Hits	688	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

APBA3_HUMAN
NC score	0.001512 (rank : 1543)	θ value	6.88961 (rank : 1134)
Query Neighborhood Hits	1243	Target Neighborhood Hits	201	Shared Neighborhood Hits	35
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

FIGN_HUMAN
NC score	0.001400 (rank : 1544)	θ value	2.36792 (rank : 1003)
Query Neighborhood Hits	1243	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

NOS1_HUMAN
NC score	0.001244 (rank : 1545)	θ value	4.03905 (rank : 1078)
Query Neighborhood Hits	1243	Target Neighborhood Hits	218	Shared Neighborhood Hits	42
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SIX5_HUMAN
NC score	0.001217 (rank : 1546)	θ value	3.0926 (rank : 1054)
Query Neighborhood Hits	1243	Target Neighborhood Hits	386	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N196	Gene names	SIX5, DMAHP
Domain Architecture	No domain graphic available
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein).

HXB3_HUMAN
NC score	0.001167 (rank : 1547)	θ value	2.36792 (rank : 1007)
Query Neighborhood Hits	1243	Target Neighborhood Hits	559	Shared Neighborhood Hits	127
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

CREB1_MOUSE
NC score	0.001147 (rank : 1548)	θ value	4.03905 (rank : 1064)
Query Neighborhood Hits	1243	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q01147	Gene names	Creb1, Creb-1
Domain Architecture
Description	cAMP response element-binding protein (CREB).

FIGN_MOUSE
NC score	0.000966 (rank : 1549)	θ value	3.0926 (rank : 1039)
Query Neighborhood Hits	1243	Target Neighborhood Hits	165	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

ARVC_MOUSE
NC score	0.000930 (rank : 1550)	θ value	1.81305 (rank : 968)
Query Neighborhood Hits	1243	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	P98203, Q6PGJ6, Q8BQ36, Q8BRF2, Q8C3U7, Q924L2, Q924L3, Q924L4, Q924L5	Gene names	Arvcf
Domain Architecture	No domain graphic available
Description	Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.

ARS2_MOUSE
NC score	0.000907 (rank : 1551)	θ value	8.99809 (rank : 1191)
Query Neighborhood Hits	1243	Target Neighborhood Hits	212	Shared Neighborhood Hits	25
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

ARS2_HUMAN
NC score	0.000811 (rank : 1552)	θ value	8.99809 (rank : 1190)
Query Neighborhood Hits	1243	Target Neighborhood Hits	186	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

HXA3_MOUSE
NC score	0.000638 (rank : 1553)	θ value	0.125558 (rank : 798)
Query Neighborhood Hits	1243	Target Neighborhood Hits	558	Shared Neighborhood Hits	90
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

LRP10_HUMAN
NC score	0.000556 (rank : 1554)	θ value	3.0926 (rank : 1042)
Query Neighborhood Hits	1243	Target Neighborhood Hits	197	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

PKP4_HUMAN
NC score	0.000537 (rank : 1555)	θ value	8.99809 (rank : 1227)
Query Neighborhood Hits	1243	Target Neighborhood Hits	107	Shared Neighborhood Hits	22
SwissProt Accessions	Q99569	Gene names	PKP4
Domain Architecture
Description	Plakophilin-4 (p0071).

TCAL3_HUMAN
NC score	0.000430 (rank : 1556)	θ value	6.88961 (rank : 1181)
Query Neighborhood Hits	1243	Target Neighborhood Hits	274	Shared Neighborhood Hits	31
SwissProt Accessions	Q969E4	Gene names	TCEAL3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

CSTFT_HUMAN
NC score	0.000428 (rank : 1557)	θ value	2.36792 (rank : 997)
Query Neighborhood Hits	1243	Target Neighborhood Hits	292	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

JPH4_HUMAN
NC score	0.000242 (rank : 1558)	θ value	4.03905 (rank : 1071)
Query Neighborhood Hits	1243	Target Neighborhood Hits	103	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

HXA3_HUMAN
NC score	0.000171 (rank : 1559)	θ value	1.81305 (rank : 982)
Query Neighborhood Hits	1243	Target Neighborhood Hits	535	Shared Neighborhood Hits	87
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

PGCB_HUMAN
NC score	0.000165 (rank : 1560)	θ value	5.27518 (rank : 1111)
Query Neighborhood Hits	1243	Target Neighborhood Hits	478	Shared Neighborhood Hits	42
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

DDX51_HUMAN
NC score	-0.000117 (rank : 1561)	θ value	5.27518 (rank : 1099)
Query Neighborhood Hits	1243	Target Neighborhood Hits	332	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

OSBP2_HUMAN
NC score	-0.000178 (rank : 1562)	θ value	8.99809 (rank : 1226)
Query Neighborhood Hits	1243	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

KCNQ2_HUMAN
NC score	-0.000236 (rank : 1563)	θ value	0.47712 (rank : 873)
Query Neighborhood Hits	1243	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

DOK2_HUMAN
NC score	-0.000248 (rank : 1564)	θ value	8.99809 (rank : 1200)
Query Neighborhood Hits	1243	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

FOXL1_HUMAN
NC score	-0.000305 (rank : 1565)	θ value	1.81305 (rank : 978)
Query Neighborhood Hits	1243	Target Neighborhood Hits	114	Shared Neighborhood Hits	19
SwissProt Accessions	Q12952, Q9H242	Gene names	FOXL1, FKHL11, FREAC7
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead- related transcription factor 7) (FREAC-7).

HDA10_HUMAN
NC score	-0.000316 (rank : 1566)	θ value	5.27518 (rank : 1103)
Query Neighborhood Hits	1243	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q969S8, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2	Gene names	HDAC10
Domain Architecture
Description	Histone deacetylase 10 (HD10).

SORC3_MOUSE
NC score	-0.000649 (rank : 1567)	θ value	8.99809 (rank : 1238)
Query Neighborhood Hits	1243	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SEM6B_HUMAN
NC score	-0.000906 (rank : 1568)	θ value	6.88961 (rank : 1171)
Query Neighborhood Hits	1243	Target Neighborhood Hits	187	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H3T3, Q9NRK9	Gene names	SEMA6B, SEMAZ
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin Z) (Sema Z).

TNR1B_MOUSE
NC score	-0.001024 (rank : 1569)	θ value	5.27518 (rank : 1131)
Query Neighborhood Hits	1243	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

LOXL2_MOUSE
NC score	-0.001335 (rank : 1570)	θ value	1.81305 (rank : 984)
Query Neighborhood Hits	1243	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39	Gene names	Loxl2
Domain Architecture	No domain graphic available
Description	Lysyl oxidase homolog 2 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 2).

ZN687_HUMAN
NC score	-0.001361 (rank : 1571)	θ value	1.81305 (rank : 992)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1244	Shared Neighborhood Hits	245
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

NOS1_MOUSE
NC score	-0.001367 (rank : 1572)	θ value	8.99809 (rank : 1224)
Query Neighborhood Hits	1243	Target Neighborhood Hits	155	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ZO1_MOUSE
NC score	-0.001374 (rank : 1573)	θ value	6.88961 (rank : 1185)
Query Neighborhood Hits	1243	Target Neighborhood Hits	453	Shared Neighborhood Hits	67
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

FOG1_MOUSE
NC score	-0.001498 (rank : 1574)	θ value	0.279714 (rank : 832)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1237	Shared Neighborhood Hits	210
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

SOX11_MOUSE
NC score	-0.001634 (rank : 1575)	θ value	3.0926 (rank : 1055)
Query Neighborhood Hits	1243	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q7M6Y2, O35178, O89036, Q04889, Q80XF0	Gene names	Sox11, Sox-11
Domain Architecture	No domain graphic available
Description	Transcription factor SOX-11.

JAD1C_HUMAN
NC score	-0.001749 (rank : 1576)	θ value	5.27518 (rank : 1104)
Query Neighborhood Hits	1243	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	P41229	Gene names	SMCX, DXS1272E, JARID1C, XE169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (Protein SmcX) (Protein Xe169).

TRI47_HUMAN
NC score	-0.001969 (rank : 1577)	θ value	0.47712 (rank : 881)
Query Neighborhood Hits	1243	Target Neighborhood Hits	286	Shared Neighborhood Hits	22
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

GP152_MOUSE
NC score	-0.001986 (rank : 1578)	θ value	1.38821 (rank : 956)
Query Neighborhood Hits	1243	Target Neighborhood Hits	607	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

KCNC3_HUMAN
NC score	-0.002662 (rank : 1579)	θ value	4.03905 (rank : 1072)
Query Neighborhood Hits	1243	Target Neighborhood Hits	256	Shared Neighborhood Hits	54
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

HXD3_HUMAN
NC score	-0.002975 (rank : 1580)	θ value	0.00869519 (rank : 689)
Query Neighborhood Hits	1243	Target Neighborhood Hits	433	Shared Neighborhood Hits	47
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

TRI47_MOUSE
NC score	-0.003226 (rank : 1581)	θ value	5.27518 (rank : 1132)
Query Neighborhood Hits	1243	Target Neighborhood Hits	295	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

PO5FL_HUMAN
NC score	-0.003317 (rank : 1582)	θ value	3.0926 (rank : 1049)
Query Neighborhood Hits	1243	Target Neighborhood Hits	214	Shared Neighborhood Hits	11
SwissProt Accessions	Q06416, Q9BZV9	Gene names	POU5F1P1, OTF3C, POU5FLC8
Domain Architecture
Description	POU domain, class 5, transcription factor 1-like protein 1 (Octamer- binding protein 3-like).

PO5FM_HUMAN
NC score	-0.003347 (rank : 1583)	θ value	3.0926 (rank : 1050)
Query Neighborhood Hits	1243	Target Neighborhood Hits	212	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZV7	Gene names	POU5F1P1, POU5FLC20
Domain Architecture
Description	POU domain, class 5, transcription factor 1-like protein 2.

BAI1_HUMAN
NC score	-0.003459 (rank : 1584)	θ value	5.27518 (rank : 1091)
Query Neighborhood Hits	1243	Target Neighborhood Hits	375	Shared Neighborhood Hits	59
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

KBTBB_HUMAN
NC score	-0.003493 (rank : 1585)	θ value	8.99809 (rank : 1213)
Query Neighborhood Hits	1243	Target Neighborhood Hits	195	Shared Neighborhood Hits	22
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

GP153_HUMAN
NC score	-0.003790 (rank : 1586)	θ value	4.03905 (rank : 1069)
Query Neighborhood Hits	1243	Target Neighborhood Hits	332	Shared Neighborhood Hits	17
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

KLD7B_HUMAN
NC score	-0.003907 (rank : 1587)	θ value	8.99809 (rank : 1215)
Query Neighborhood Hits	1243	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q96G42	Gene names	KLHDC7B
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 7B.

ITCH_MOUSE
NC score	-0.004169 (rank : 1588)	θ value	6.88961 (rank : 1151)
Query Neighborhood Hits	1243	Target Neighborhood Hits	127	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ZFHX2_HUMAN
NC score	-0.004481 (rank : 1589)	θ value	0.47712 (rank : 885)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1178	Shared Neighborhood Hits	130
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

RXRA_HUMAN
NC score	-0.004759 (rank : 1590)	θ value	0.62314 (rank : 900)
Query Neighborhood Hits	1243	Target Neighborhood Hits	223	Shared Neighborhood Hits	44
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

HXD11_MOUSE
NC score	-0.005219 (rank : 1591)	θ value	0.279714 (rank : 833)
Query Neighborhood Hits	1243	Target Neighborhood Hits	376	Shared Neighborhood Hits	28
SwissProt Accessions	P23813	Gene names	Hoxd11, Hox-4.6, Hoxd-11
Domain Architecture
Description	Homeobox protein Hox-D11 (Hox-4.6) (Hox-5.5).

ATBF1_MOUSE
NC score	-0.005419 (rank : 1592)	θ value	0.365318 (rank : 846)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1841	Shared Neighborhood Hits	187
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BAI1_MOUSE
NC score	-0.005701 (rank : 1593)	θ value	5.27518 (rank : 1092)
Query Neighborhood Hits	1243	Target Neighborhood Hits	340	Shared Neighborhood Hits	49
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

PRDM2_HUMAN
NC score	-0.005955 (rank : 1594)	θ value	0.000602161 (rank : 611)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1135	Shared Neighborhood Hits	116
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

FOG1_HUMAN
NC score	-0.006451 (rank : 1595)	θ value	0.00390308 (rank : 669)
Query Neighborhood Hits	1243	Target Neighborhood Hits	981	Shared Neighborhood Hits	102
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

RTN4R_HUMAN
NC score	-0.006663 (rank : 1596)	θ value	0.62314 (rank : 899)
Query Neighborhood Hits	1243	Target Neighborhood Hits	271	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

PHLPP_MOUSE
NC score	-0.006978 (rank : 1597)	θ value	5.27518 (rank : 1112)
Query Neighborhood Hits	1243	Target Neighborhood Hits	394	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

HXA4_MOUSE
NC score	-0.007140 (rank : 1598)	θ value	1.06291 (rank : 935)
Query Neighborhood Hits	1243	Target Neighborhood Hits	379	Shared Neighborhood Hits	30
SwissProt Accessions	P06798, Q61684, Q64388, Q8BPE6	Gene names	Hoxa4, Hox-1.4, Hoxa-4
Domain Architecture
Description	Homeobox protein Hox-A4 (Hox-1.4) (Homeobox protein MH-3).

FMOD_HUMAN
NC score	-0.007186 (rank : 1599)	θ value	0.365318 (rank : 854)
Query Neighborhood Hits	1243	Target Neighborhood Hits	283	Shared Neighborhood Hits	9
SwissProt Accessions	Q06828, Q15331	Gene names	FMOD, FM
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

FMOD_MOUSE
NC score	-0.007352 (rank : 1600)	θ value	0.47712 (rank : 867)
Query Neighborhood Hits	1243	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

LRC47_MOUSE
NC score	-0.007527 (rank : 1601)	θ value	2.36792 (rank : 1010)
Query Neighborhood Hits	1243	Target Neighborhood Hits	299	Shared Neighborhood Hits	9
SwissProt Accessions	Q505F5, Q3U380, Q6ZPW2, Q9CUZ0	Gene names	Lrrc47, Kiaa1185
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 47.

NR1H2_HUMAN
NC score	-0.007644 (rank : 1602)	θ value	8.99809 (rank : 1225)
Query Neighborhood Hits	1243	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

HXC12_MOUSE
NC score	-0.008057 (rank : 1603)	θ value	1.81305 (rank : 983)
Query Neighborhood Hits	1243	Target Neighborhood Hits	316	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K5B8	Gene names	Hoxc12, Hox-3.8, Hoxc-12
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C12 (Hox-3.8).

LRC47_HUMAN
NC score	-0.008609 (rank : 1604)	θ value	6.88961 (rank : 1155)
Query Neighborhood Hits	1243	Target Neighborhood Hits	300	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N1G4, Q9ULN5	Gene names	LRRC47, KIAA1185
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 47.

KLHL1_HUMAN
NC score	-0.009416 (rank : 1605)	θ value	6.88961 (rank : 1153)
Query Neighborhood Hits	1243	Target Neighborhood Hits	195	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR64, Q5VZ64, Q9H4X4, Q9NR65, Q9P238	Gene names	KLHL1, KIAA1490
Domain Architecture
Description	Kelch-like protein 1.

OTP_MOUSE
NC score	-0.010116 (rank : 1606)	θ value	6.88961 (rank : 1162)
Query Neighborhood Hits	1243	Target Neighborhood Hits	387	Shared Neighborhood Hits	27
SwissProt Accessions	O09113	Gene names	Otp
Domain Architecture
Description	Homeobox protein orthopedia.

EVX2_HUMAN
NC score	-0.010177 (rank : 1607)	θ value	8.99809 (rank : 1203)
Query Neighborhood Hits	1243	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	Q03828	Gene names	EVX2
Domain Architecture
Description	Homeobox even-skipped homolog protein 2 (EVX-2).

BACH1_MOUSE
NC score	-0.010177 (rank : 1608)	θ value	6.88961 (rank : 1136)
Query Neighborhood Hits	1243	Target Neighborhood Hits	289	Shared Neighborhood Hits	10
SwissProt Accessions	P97302	Gene names	Bach1
Domain Architecture
Description	Transcription regulator protein BACH1 (BTB and CNC homolog 1).

ATBF1_HUMAN
NC score	-0.011332 (rank : 1609)	θ value	0.279714 (rank : 830)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1547	Shared Neighborhood Hits	129
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ZN687_MOUSE
NC score	-0.011855 (rank : 1610)	θ value	2.36792 (rank : 1022)
Query Neighborhood Hits	1243	Target Neighborhood Hits	913	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

INSM1_HUMAN
NC score	-0.017481 (rank : 1611)	θ value	6.88961 (rank : 1150)
Query Neighborhood Hits	1243	Target Neighborhood Hits	683	Shared Neighborhood Hits	34
SwissProt Accessions	Q01101	Gene names	INSM1, IA1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

RREB1_HUMAN
NC score	-0.017850 (rank : 1612)	θ value	4.03905 (rank : 1081)
Query Neighborhood Hits	1243	Target Neighborhood Hits	879	Shared Neighborhood Hits	70
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

POGZ_MOUSE
NC score	-0.018671 (rank : 1613)	θ value	6.88961 (rank : 1167)
Query Neighborhood Hits	1243	Target Neighborhood Hits	765	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZH4, Q4VA94, Q80TZ8, Q8C0K1, Q8K294	Gene names	Pogz, Kiaa0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

ZXDB_HUMAN
NC score	-0.018747 (rank : 1614)	θ value	0.0148317 (rank : 716)
Query Neighborhood Hits	1243	Target Neighborhood Hits	753	Shared Neighborhood Hits	39
SwissProt Accessions	P98169, Q9UBB3	Gene names	ZXDB
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDB.

ZXDA_HUMAN
NC score	-0.019049 (rank : 1615)	θ value	0.0431538 (rank : 752)
Query Neighborhood Hits	1243	Target Neighborhood Hits	750	Shared Neighborhood Hits	37
SwissProt Accessions	P98168, Q9UJP7	Gene names	ZXDA
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDA.

GLI1_MOUSE
NC score	-0.020026 (rank : 1616)	θ value	1.81305 (rank : 979)
Query Neighborhood Hits	1243	Target Neighborhood Hits	785	Shared Neighborhood Hits	49
SwissProt Accessions	P47806, Q9QYK1	Gene names	Gli1, Gli
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene homolog).

MTF1_HUMAN
NC score	-0.020601 (rank : 1617)	θ value	8.99809 (rank : 1220)
Query Neighborhood Hits	1243	Target Neighborhood Hits	814	Shared Neighborhood Hits	51
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

SP7_MOUSE
NC score	-0.020639 (rank : 1618)	θ value	5.27518 (rank : 1126)
Query Neighborhood Hits	1243	Target Neighborhood Hits	756	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VI67, Q8C5R3, Q8C6A7	Gene names	Sp7, Osx
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix) (C22).

ZN692_HUMAN
NC score	-0.020982 (rank : 1619)	θ value	1.81305 (rank : 993)
Query Neighborhood Hits	1243	Target Neighborhood Hits	808	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

TCF8_MOUSE
NC score	-0.021099 (rank : 1620)	θ value	5.27518 (rank : 1130)
Query Neighborhood Hits	1243	Target Neighborhood Hits	1067	Shared Neighborhood Hits	77
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

KLF13_MOUSE
NC score	-0.021429 (rank : 1621)	θ value	6.88961 (rank : 1152)
Query Neighborhood Hits	1243	Target Neighborhood Hits	757	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JJZ6, Q9ESX3, Q9JHF8	Gene names	Klf13, Bteb3, Fklf2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Erythroid transcription factor FKLF-2).

KLF2_MOUSE
NC score	-0.021802 (rank : 1622)	θ value	8.99809 (rank : 1216)
Query Neighborhood Hits	1243	Target Neighborhood Hits	738	Shared Neighborhood Hits	39
SwissProt Accessions	Q60843	Gene names	Klf2, Lklf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 2 (Lung krueppel-like factor).

ZKSC1_MOUSE
NC score	-0.022336 (rank : 1623)	θ value	1.81305 (rank : 991)
Query Neighborhood Hits	1243	Target Neighborhood Hits	755	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BGS3, Q7TS88, Q8BJ55, Q9CRN6	Gene names	Zkscan1
Domain Architecture	No domain graphic available
Description	Zinc finger with KRAB and SCAN domain-containing protein 1.

ADRB1_MOUSE
NC score	-0.022426 (rank : 1624)	θ value	0.62314 (rank : 886)
Query Neighborhood Hits	1243	Target Neighborhood Hits	864	Shared Neighborhood Hits	4
SwissProt Accessions	P34971	Gene names	Adrb1, Adrb1r
Domain Architecture
Description	Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1 adrenoreceptor).

ZN694_HUMAN
NC score	-0.022464 (rank : 1625)	θ value	5.27518 (rank : 1133)
Query Neighborhood Hits	1243	Target Neighborhood Hits	764	Shared Neighborhood Hits	30
SwissProt Accessions	Q63HK3, Q6ZN77	Gene names	ZNF694
Domain Architecture	No domain graphic available
Description	Zinc finger protein 694.