Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : LCP2_MOUSE

For an explanation of this page, click here

LCP2_MOUSE
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LCP2_HUMAN
θ value	0 (rank : 1)	NC score	0.806570 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	531	Shared Neighborhood Hits	127
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BLNK_MOUSE
θ value	1.92812e-18 (rank : 3)	NC score	0.588797 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	296	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BLNK_HUMAN
θ value	6.20254e-17 (rank : 4)	NC score	0.589905 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

PLCG1_HUMAN
θ value	8.97725e-08 (rank : 5)	NC score	0.350821 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	76
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	8.97725e-08 (rank : 6)	NC score	0.348209 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	76
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DAPP1_HUMAN
θ value	2.21117e-06 (rank : 7)	NC score	0.390341 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	8.40245e-06 (rank : 8)	NC score	0.382937 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NCK1_HUMAN
θ value	1.43324e-05 (rank : 9)	NC score	0.340420 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	78
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	3.19293e-05 (rank : 10)	NC score	0.341132 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PLCG2_HUMAN
θ value	0.000121331 (rank : 11)	NC score	0.328333 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	280	Shared Neighborhood Hits	75
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PTN11_HUMAN
θ value	0.000158464 (rank : 12)	NC score	0.206066 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.000158464 (rank : 13)	NC score	0.206089 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

SRC_HUMAN
θ value	0.000602161 (rank : 14)	NC score	0.140642 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	1058	Shared Neighborhood Hits	85
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.000602161 (rank : 15)	NC score	0.140780 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	1033	Shared Neighborhood Hits	84
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

GRAP_MOUSE
θ value	0.00175202 (rank : 16)	NC score	0.301017 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	309	Shared Neighborhood Hits	77
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CEL_HUMAN
θ value	0.00228821 (rank : 17)	NC score	0.069694 (rank : 253)
Query Neighborhood Hits	177	Target Neighborhood Hits	896	Shared Neighborhood Hits	39
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

GRAP_HUMAN
θ value	0.00228821 (rank : 18)	NC score	0.299994 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SHC3_MOUSE
θ value	0.00509761 (rank : 19)	NC score	0.296398 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	151	Shared Neighborhood Hits	76
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

PTK6_MOUSE
θ value	0.00665767 (rank : 20)	NC score	0.117440 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	1026	Shared Neighborhood Hits	75
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN6_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.172104 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	0.00869519 (rank : 22)	NC score	0.277785 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	258	Shared Neighborhood Hits	74
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

BTK_HUMAN
θ value	0.0113563 (rank : 23)	NC score	0.141017 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	1026	Shared Neighborhood Hits	80
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	0.0113563 (rank : 24)	NC score	0.140533 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	1017	Shared Neighborhood Hits	79
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RGS3_HUMAN
θ value	0.0113563 (rank : 25)	NC score	0.074760 (rank : 219)
Query Neighborhood Hits	177	Target Neighborhood Hits	1375	Shared Neighborhood Hits	55
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SHC2_MOUSE
θ value	0.0148317 (rank : 26)	NC score	0.264891 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

BMX_HUMAN
θ value	0.0252991 (rank : 27)	NC score	0.125741 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	942	Shared Neighborhood Hits	71
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FGR_MOUSE
θ value	0.0252991 (rank : 28)	NC score	0.146325 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	1069	Shared Neighborhood Hits	87
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NSD1_HUMAN
θ value	0.0252991 (rank : 29)	NC score	0.071192 (rank : 239)
Query Neighborhood Hits	177	Target Neighborhood Hits	427	Shared Neighborhood Hits	29
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

ANK2_HUMAN
θ value	0.0330416 (rank : 30)	NC score	0.040376 (rank : 524)
Query Neighborhood Hits	177	Target Neighborhood Hits	1615	Shared Neighborhood Hits	53
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

P85B_HUMAN
θ value	0.0330416 (rank : 31)	NC score	0.262767 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PTN6_HUMAN
θ value	0.0330416 (rank : 32)	NC score	0.165068 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	234	Shared Neighborhood Hits	72
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

RGS3_MOUSE
θ value	0.0330416 (rank : 33)	NC score	0.078770 (rank : 194)
Query Neighborhood Hits	177	Target Neighborhood Hits	1621	Shared Neighborhood Hits	67
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SH21B_HUMAN
θ value	0.0330416 (rank : 34)	NC score	0.287875 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	57
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

EFS_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.097939 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	54
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FGR_HUMAN
θ value	0.0431538 (rank : 36)	NC score	0.141040 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	1067	Shared Neighborhood Hits	86
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYB_HUMAN
θ value	0.0563607 (rank : 37)	NC score	0.121282 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	379	Shared Neighborhood Hits	32
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

TEC_HUMAN
θ value	0.0563607 (rank : 38)	NC score	0.130543 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	1006	Shared Neighborhood Hits	78
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SH21B_MOUSE
θ value	0.0736092 (rank : 39)	NC score	0.272475 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXK_HUMAN
θ value	0.0736092 (rank : 40)	NC score	0.130314 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	971	Shared Neighborhood Hits	79
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

GRB2_HUMAN
θ value	0.0961366 (rank : 41)	NC score	0.273837 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	79
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.0961366 (rank : 42)	NC score	0.274468 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	81
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

LYN_HUMAN
θ value	0.0961366 (rank : 43)	NC score	0.124172 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	1022	Shared Neighborhood Hits	78
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MDC1_MOUSE
θ value	0.0961366 (rank : 44)	NC score	0.062172 (rank : 339)
Query Neighborhood Hits	177	Target Neighborhood Hits	998	Shared Neighborhood Hits	49
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

P85A_MOUSE
θ value	0.0961366 (rank : 45)	NC score	0.239083 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	74
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHC3_HUMAN
θ value	0.0961366 (rank : 46)	NC score	0.282521 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	155	Shared Neighborhood Hits	74
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

TACC1_MOUSE
θ value	0.0961366 (rank : 47)	NC score	0.039288 (rank : 527)
Query Neighborhood Hits	177	Target Neighborhood Hits	667	Shared Neighborhood Hits	20
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TXK_MOUSE
θ value	0.0961366 (rank : 48)	NC score	0.129750 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	980	Shared Neighborhood Hits	80
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BMX_MOUSE
θ value	0.125558 (rank : 49)	NC score	0.124987 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	912	Shared Neighborhood Hits	71
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

P85B_MOUSE
θ value	0.125558 (rank : 50)	NC score	0.258404 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	519	Shared Neighborhood Hits	81
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TEC_MOUSE
θ value	0.125558 (rank : 51)	NC score	0.127762 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	1006	Shared Neighborhood Hits	77
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LYN_MOUSE
θ value	0.163984 (rank : 52)	NC score	0.124335 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	1023	Shared Neighborhood Hits	78
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

P55G_HUMAN
θ value	0.163984 (rank : 53)	NC score	0.259161 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	451	Shared Neighborhood Hits	70
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	0.163984 (rank : 54)	NC score	0.257886 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	401	Shared Neighborhood Hits	69
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHC2_HUMAN
θ value	0.163984 (rank : 55)	NC score	0.253483 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	74
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SOCS2_HUMAN
θ value	0.163984 (rank : 56)	NC score	0.206474 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	104	Shared Neighborhood Hits	53
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	0.163984 (rank : 57)	NC score	0.209355 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	53
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SRMS_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.111367 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	964	Shared Neighborhood Hits	75
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BAT2_MOUSE
θ value	0.21417 (rank : 59)	NC score	0.099834 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	947	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

PYR1_HUMAN
θ value	0.21417 (rank : 60)	NC score	0.049573 (rank : 518)
Query Neighborhood Hits	177	Target Neighborhood Hits	119	Shared Neighborhood Hits	7
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

QSCN6_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.039634 (rank : 526)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

HCK_HUMAN
θ value	0.279714 (rank : 62)	NC score	0.127215 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	1035	Shared Neighborhood Hits	79
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

P85A_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.234819 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	479	Shared Neighborhood Hits	72
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNPC4_HUMAN
θ value	0.279714 (rank : 64)	NC score	0.068515 (rank : 262)
Query Neighborhood Hits	177	Target Neighborhood Hits	589	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SON_HUMAN
θ value	0.279714 (rank : 65)	NC score	0.057184 (rank : 415)
Query Neighborhood Hits	177	Target Neighborhood Hits	1568	Shared Neighborhood Hits	67
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CISH_MOUSE
θ value	0.365318 (rank : 66)	NC score	0.181945 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

ZAP70_MOUSE
θ value	0.365318 (rank : 67)	NC score	0.105078 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	905	Shared Neighborhood Hits	77
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZCH14_HUMAN
θ value	0.365318 (rank : 68)	NC score	0.085067 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WYQ9, O60324, Q9UFP0	Gene names	ZCCHC14, KIAA0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

ZN516_MOUSE
θ value	0.365318 (rank : 69)	NC score	0.012026 (rank : 560)
Query Neighborhood Hits	177	Target Neighborhood Hits	1197	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CRKL_MOUSE
θ value	0.47712 (rank : 70)	NC score	0.235705 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	77
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GON4L_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.053907 (rank : 463)
Query Neighborhood Hits	177	Target Neighborhood Hits	555	Shared Neighborhood Hits	28
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

MAGE1_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.049919 (rank : 517)
Query Neighborhood Hits	177	Target Neighborhood Hits	1389	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SOCS6_HUMAN
θ value	0.47712 (rank : 73)	NC score	0.185224 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	52
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	0.47712 (rank : 74)	NC score	0.186444 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	146	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

ZAP70_HUMAN
θ value	0.47712 (rank : 75)	NC score	0.103296 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	893	Shared Neighborhood Hits	78
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CISH_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.181274 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

FYN_HUMAN
θ value	0.62314 (rank : 77)	NC score	0.130683 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	1078	Shared Neighborhood Hits	84
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.62314 (rank : 78)	NC score	0.132469 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	1073	Shared Neighborhood Hits	83
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

HCK_MOUSE
θ value	0.62314 (rank : 79)	NC score	0.126985 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	1029	Shared Neighborhood Hits	79
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

T22D4_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.068733 (rank : 259)
Query Neighborhood Hits	177	Target Neighborhood Hits	403	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

VAV_HUMAN
θ value	0.62314 (rank : 81)	NC score	0.164645 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	452	Shared Neighborhood Hits	72
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

YYAP1_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.052397 (rank : 483)
Query Neighborhood Hits	177	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H869, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84	Gene names	YY1AP1, HCCA2, YY1AP
Domain Architecture	No domain graphic available
Description	YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2).

ZCH14_MOUSE
θ value	0.62314 (rank : 83)	NC score	0.082429 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VIG0, Q80TX3, Q91VU4	Gene names	Zcchc14, Kiaa0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

ZEP1_MOUSE
θ value	0.62314 (rank : 84)	NC score	0.014663 (rank : 557)
Query Neighborhood Hits	177	Target Neighborhood Hits	1063	Shared Neighborhood Hits	26
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

FER_HUMAN
θ value	0.813845 (rank : 85)	NC score	0.109356 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	1278	Shared Neighborhood Hits	88
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

PRG4_HUMAN
θ value	0.813845 (rank : 86)	NC score	0.099705 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	764	Shared Neighborhood Hits	42
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SPEG_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.047582 (rank : 520)
Query Neighborhood Hits	177	Target Neighborhood Hits	1959	Shared Neighborhood Hits	83
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZO1_HUMAN
θ value	0.813845 (rank : 88)	NC score	0.036232 (rank : 532)
Query Neighborhood Hits	177	Target Neighborhood Hits	474	Shared Neighborhood Hits	24
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

AHR_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.021865 (rank : 550)
Query Neighborhood Hits	177	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CTRO_HUMAN
θ value	1.06291 (rank : 90)	NC score	0.032460 (rank : 539)
Query Neighborhood Hits	177	Target Neighborhood Hits	2092	Shared Neighborhood Hits	60
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ITK_HUMAN
θ value	1.06291 (rank : 91)	NC score	0.120608 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	1016	Shared Neighborhood Hits	76
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	1.06291 (rank : 92)	NC score	0.120791 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	985	Shared Neighborhood Hits	72
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

K1267_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.046757 (rank : 521)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z3B3, Q6AW85, Q8IYH1, Q9NTE7, Q9UFT0, Q9ULF3	Gene names	KIAA1267
Domain Architecture	No domain graphic available
Description	Protein KIAA1267.

K1543_MOUSE
θ value	1.06291 (rank : 94)	NC score	0.055206 (rank : 443)
Query Neighborhood Hits	177	Target Neighborhood Hits	497	Shared Neighborhood Hits	32
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

NCOA6_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.079264 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	1202	Shared Neighborhood Hits	56
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SASH1_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.052797 (rank : 475)
Query Neighborhood Hits	177	Target Neighborhood Hits	263	Shared Neighborhood Hits	30
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21A_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.249130 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

TYK2_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.061311 (rank : 354)
Query Neighborhood Hits	177	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

VAV_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.157367 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	430	Shared Neighborhood Hits	71
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WASIP_HUMAN
θ value	1.06291 (rank : 100)	NC score	0.153596 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	458	Shared Neighborhood Hits	43
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

FMNL_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.074787 (rank : 218)
Query Neighborhood Hits	177	Target Neighborhood Hits	529	Shared Neighborhood Hits	37
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GRB14_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.187408 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	149	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HRX_HUMAN
θ value	1.38821 (rank : 103)	NC score	0.072097 (rank : 236)
Query Neighborhood Hits	177	Target Neighborhood Hits	825	Shared Neighborhood Hits	41
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

JPH2_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.033970 (rank : 536)
Query Neighborhood Hits	177	Target Neighborhood Hits	639	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LEO1_MOUSE
θ value	1.38821 (rank : 105)	NC score	0.034173 (rank : 534)
Query Neighborhood Hits	177	Target Neighborhood Hits	946	Shared Neighborhood Hits	20
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MLL3_HUMAN
θ value	1.38821 (rank : 106)	NC score	0.063713 (rank : 308)
Query Neighborhood Hits	177	Target Neighborhood Hits	1644	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

YES_MOUSE
θ value	1.38821 (rank : 107)	NC score	0.131902 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	1052	Shared Neighborhood Hits	83
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CTRO_MOUSE
θ value	1.81305 (rank : 108)	NC score	0.030157 (rank : 542)
Query Neighborhood Hits	177	Target Neighborhood Hits	2344	Shared Neighborhood Hits	61
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

FA47A_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.070659 (rank : 244)
Query Neighborhood Hits	177	Target Neighborhood Hits	451	Shared Neighborhood Hits	34
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

MLL3_MOUSE
θ value	1.81305 (rank : 110)	NC score	0.064583 (rank : 300)
Query Neighborhood Hits	177	Target Neighborhood Hits	1399	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PCLO_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.069121 (rank : 256)
Query Neighborhood Hits	177	Target Neighborhood Hits	2046	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PRG4_MOUSE
θ value	1.81305 (rank : 112)	NC score	0.086096 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	624	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SFPQ_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.072875 (rank : 227)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SHAN2_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.049199 (rank : 519)
Query Neighborhood Hits	177	Target Neighborhood Hits	346	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

THAP3_HUMAN
θ value	1.81305 (rank : 115)	NC score	0.029340 (rank : 543)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WTV1, Q569K1, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3	Gene names	THAP3
Domain Architecture
Description	THAP domain-containing protein 3.

YES_HUMAN
θ value	1.81305 (rank : 116)	NC score	0.131555 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	1059	Shared Neighborhood Hits	82
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BAT2_HUMAN
θ value	2.36792 (rank : 117)	NC score	0.081489 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	931	Shared Neighborhood Hits	53
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CECR2_HUMAN
θ value	2.36792 (rank : 118)	NC score	0.031945 (rank : 540)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CRK_HUMAN
θ value	2.36792 (rank : 119)	NC score	0.227453 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	308	Shared Neighborhood Hits	79
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	2.36792 (rank : 120)	NC score	0.223977 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	79
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NFAC1_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.030659 (rank : 541)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	27
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

PAIRB_HUMAN
θ value	2.36792 (rank : 122)	NC score	0.051764 (rank : 491)
Query Neighborhood Hits	177	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NC51, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3	Gene names	SERBP1, PAIRBP1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

PHAR3_MOUSE
θ value	2.36792 (rank : 123)	NC score	0.027305 (rank : 546)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BYK5, Q8BYS8, Q8C058, Q9DB87	Gene names	Phactr3, Scapin1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

SH21A_HUMAN
θ value	2.36792 (rank : 124)	NC score	0.241293 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SHC1_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.237205 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	72
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.246537 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	180	Shared Neighborhood Hits	74
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ATAD2_MOUSE
θ value	3.0926 (rank : 127)	NC score	0.010324 (rank : 564)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

CEP72_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.020707 (rank : 552)
Query Neighborhood Hits	177	Target Neighborhood Hits	374	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

CLCN1_HUMAN
θ value	3.0926 (rank : 129)	NC score	0.023553 (rank : 549)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	8
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

ELOA3_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.037589 (rank : 530)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

PRRT3_HUMAN
θ value	3.0926 (rank : 131)	NC score	0.061207 (rank : 359)
Query Neighborhood Hits	177	Target Neighborhood Hits	998	Shared Neighborhood Hits	44
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SH23A_HUMAN
θ value	3.0926 (rank : 132)	NC score	0.132056 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

TITIN_HUMAN
θ value	3.0926 (rank : 133)	NC score	0.038887 (rank : 528)
Query Neighborhood Hits	177	Target Neighborhood Hits	2923	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZN580_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.000852 (rank : 572)
Query Neighborhood Hits	177	Target Neighborhood Hits	727	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UK33, Q9NPP7	Gene names	ZNF580
Domain Architecture	No domain graphic available
Description	Zinc finger protein 580 (LDL-induced EC protein).

BSN_MOUSE
θ value	4.03905 (rank : 135)	NC score	0.044914 (rank : 522)
Query Neighborhood Hits	177	Target Neighborhood Hits	2057	Shared Neighborhood Hits	70
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CYTSA_HUMAN
θ value	4.03905 (rank : 136)	NC score	0.009476 (rank : 566)
Query Neighborhood Hits	177	Target Neighborhood Hits	1138	Shared Neighborhood Hits	24
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

NRX2A_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.018313 (rank : 555)
Query Neighborhood Hits	177	Target Neighborhood Hits	614	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.027374 (rank : 545)
Query Neighborhood Hits	177	Target Neighborhood Hits	481	Shared Neighborhood Hits	21
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

ZHX2_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.011783 (rank : 561)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

AB1IP_MOUSE
θ value	5.27518 (rank : 140)	NC score	0.072496 (rank : 232)
Query Neighborhood Hits	177	Target Neighborhood Hits	181	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ASPP2_HUMAN
θ value	5.27518 (rank : 141)	NC score	0.059429 (rank : 397)
Query Neighborhood Hits	177	Target Neighborhood Hits	1156	Shared Neighborhood Hits	57
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ATX7_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.052417 (rank : 482)
Query Neighborhood Hits	177	Target Neighborhood Hits	351	Shared Neighborhood Hits	27
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

BICD1_MOUSE
θ value	5.27518 (rank : 143)	NC score	0.011462 (rank : 562)
Query Neighborhood Hits	177	Target Neighborhood Hits	837	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

FRMD6_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.010985 (rank : 563)
Query Neighborhood Hits	177	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

K1267_MOUSE
θ value	5.27518 (rank : 145)	NC score	0.037162 (rank : 531)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TG1, Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0	Gene names	Kiaa1267
Domain Architecture	No domain graphic available
Description	Protein KIAA1267.

MLL4_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.090593 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	722	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

PAIRB_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.036064 (rank : 533)
Query Neighborhood Hits	177	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CY58, Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9DBY6	Gene names	Serbp1, Pairbp1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

PHLB1_HUMAN
θ value	5.27518 (rank : 148)	NC score	0.028596 (rank : 544)
Query Neighborhood Hits	177	Target Neighborhood Hits	1038	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SETD2_HUMAN
θ value	5.27518 (rank : 149)	NC score	0.040026 (rank : 525)
Query Neighborhood Hits	177	Target Neighborhood Hits	412	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SHAN2_MOUSE
θ value	5.27518 (rank : 150)	NC score	0.068448 (rank : 264)
Query Neighborhood Hits	177	Target Neighborhood Hits	446	Shared Neighborhood Hits	44
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TM108_MOUSE
θ value	5.27518 (rank : 151)	NC score	0.042737 (rank : 523)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

UBP2L_HUMAN
θ value	5.27518 (rank : 152)	NC score	0.033200 (rank : 537)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

AB1IP_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.073811 (rank : 225)
Query Neighborhood Hits	177	Target Neighborhood Hits	213	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

CS007_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.037819 (rank : 529)
Query Neighborhood Hits	177	Target Neighborhood Hits	464	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DSPP_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.019074 (rank : 554)
Query Neighborhood Hits	177	Target Neighborhood Hits	645	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

EP300_HUMAN
θ value	6.88961 (rank : 156)	NC score	0.060132 (rank : 385)
Query Neighborhood Hits	177	Target Neighborhood Hits	821	Shared Neighborhood Hits	43
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

FA47B_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.051345 (rank : 495)
Query Neighborhood Hits	177	Target Neighborhood Hits	431	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FLIP1_MOUSE
θ value	6.88961 (rank : 158)	NC score	0.009528 (rank : 565)
Query Neighborhood Hits	177	Target Neighborhood Hits	1176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GRB7_HUMAN
θ value	6.88961 (rank : 159)	NC score	0.145912 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	65
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

LEO1_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.026488 (rank : 547)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LIMD1_HUMAN
θ value	6.88961 (rank : 161)	NC score	0.006101 (rank : 571)
Query Neighborhood Hits	177	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

SHE_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.191598 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	164	Shared Neighborhood Hits	73
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SOS1_HUMAN
θ value	6.88961 (rank : 163)	NC score	0.019390 (rank : 553)
Query Neighborhood Hits	177	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ZC313_HUMAN
θ value	6.88961 (rank : 164)	NC score	0.034025 (rank : 535)
Query Neighborhood Hits	177	Target Neighborhood Hits	772	Shared Neighborhood Hits	18
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ANKS6_MOUSE
θ value	8.99809 (rank : 165)	NC score	0.013178 (rank : 559)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	17
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

CO8A_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.008040 (rank : 568)
Query Neighborhood Hits	177	Target Neighborhood Hits	200	Shared Neighborhood Hits	3
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CXXC6_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.020747 (rank : 551)
Query Neighborhood Hits	177	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NFU7, Q5VUP7, Q7Z6B6, Q8TCR1, Q9C0I7	Gene names	CXXC6, KIAA1676, LCX
Domain Architecture	No domain graphic available
Description	CXXC-type zinc finger protein 6 (Leukemia-associated protein with a CXXC domain).

K1688_HUMAN
θ value	8.99809 (rank : 168)	NC score	0.025032 (rank : 548)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

MAST4_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.032861 (rank : 538)
Query Neighborhood Hits	177	Target Neighborhood Hits	1804	Shared Neighborhood Hits	78
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

RCN3_HUMAN
θ value	8.99809 (rank : 170)	NC score	0.007019 (rank : 570)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q96D15, Q9HBZ8	Gene names	RCN3
Domain Architecture
Description	Reticulocalbin-3 precursor (EF-hand calcium-binding protein RLP49).

SASH1_HUMAN
θ value	8.99809 (rank : 171)	NC score	0.054471 (rank : 454)
Query Neighborhood Hits	177	Target Neighborhood Hits	292	Shared Neighborhood Hits	30
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SIX5_MOUSE
θ value	8.99809 (rank : 172)	NC score	0.013799 (rank : 558)
Query Neighborhood Hits	177	Target Neighborhood Hits	354	Shared Neighborhood Hits	15
SwissProt Accessions	P70178	Gene names	Six5, Dmahp
Domain Architecture
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein homolog).

TCAL5_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.008671 (rank : 567)
Query Neighborhood Hits	177	Target Neighborhood Hits	806	Shared Neighborhood Hits	18
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TMM91_MOUSE
θ value	8.99809 (rank : 174)	NC score	0.015673 (rank : 556)
Query Neighborhood Hits	177	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C581	Gene names	Tmem91
Domain Architecture	No domain graphic available
Description	Transmembrane protein 91.

WASP_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.079325 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	195	Shared Neighborhood Hits	25
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

XKR7_HUMAN
θ value	8.99809 (rank : 176)	NC score	0.007758 (rank : 569)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q5GH72, Q9NUG5	Gene names	XKR7, C20orf159, XRG7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

ZN688_HUMAN
θ value	8.99809 (rank : 177)	NC score	-0.002933 (rank : 573)
Query Neighborhood Hits	177	Target Neighborhood Hits	873	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

3BP2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.076998 (rank : 206)
Query Neighborhood Hits	177	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AATK_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.068499 (rank : 263)
Query Neighborhood Hits	177	Target Neighborhood Hits	1243	Shared Neighborhood Hits	61
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.070866 (rank : 242)
Query Neighborhood Hits	177	Target Neighborhood Hits	942	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.076644 (rank : 208)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.072333 (rank : 233)
Query Neighborhood Hits	177	Target Neighborhood Hits	246	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.093887 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.081820 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	45
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.080780 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.072647 (rank : 228)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.121272 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	1220	Shared Neighborhood Hits	96
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.121788 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	1178	Shared Neighborhood Hits	99
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.121000 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	1045	Shared Neighborhood Hits	88
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.078792 (rank : 193)
Query Neighborhood Hits	177	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.075370 (rank : 214)
Query Neighborhood Hits	177	Target Neighborhood Hits	1080	Shared Neighborhood Hits	61
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AFF1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.052832 (rank : 473)
Query Neighborhood Hits	177	Target Neighborhood Hits	506	Shared Neighborhood Hits	40
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

AHI1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.077002 (rank : 205)
Query Neighborhood Hits	177	Target Neighborhood Hits	537	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.071095 (rank : 240)
Query Neighborhood Hits	177	Target Neighborhood Hits	496	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALEX_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.050031 (rank : 515)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	20
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ALK_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.067222 (rank : 277)
Query Neighborhood Hits	177	Target Neighborhood Hits	795	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.067387 (rank : 272)
Query Neighborhood Hits	177	Target Neighborhood Hits	811	Shared Neighborhood Hits	34
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANM2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.065465 (rank : 290)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	37
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.060274 (rank : 384)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRA_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.054267 (rank : 457)
Query Neighborhood Hits	177	Target Neighborhood Hits	612	Shared Neighborhood Hits	31
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.054077 (rank : 460)
Query Neighborhood Hits	177	Target Neighborhood Hits	600	Shared Neighborhood Hits	31
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.051180 (rank : 499)
Query Neighborhood Hits	177	Target Neighborhood Hits	646	Shared Neighborhood Hits	35
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.051563 (rank : 494)
Query Neighborhood Hits	177	Target Neighborhood Hits	607	Shared Neighborhood Hits	35
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.161648 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	162	Shared Neighborhood Hits	59
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.136654 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	134	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARAF_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.052837 (rank : 471)
Query Neighborhood Hits	177	Target Neighborhood Hits	924	Shared Neighborhood Hits	38
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.053087 (rank : 466)
Query Neighborhood Hits	177	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG6_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.072561 (rank : 230)
Query Neighborhood Hits	177	Target Neighborhood Hits	376	Shared Neighborhood Hits	39
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.070232 (rank : 248)
Query Neighborhood Hits	177	Target Neighborhood Hits	394	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.076188 (rank : 210)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	39
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.079337 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARI1B_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.064075 (rank : 303)
Query Neighborhood Hits	177	Target Neighborhood Hits	567	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

ASPP1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.062684 (rank : 331)
Query Neighborhood Hits	177	Target Neighborhood Hits	956	Shared Neighborhood Hits	54
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.071765 (rank : 238)
Query Neighborhood Hits	177	Target Neighborhood Hits	1244	Shared Neighborhood Hits	71
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ATN1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.068708 (rank : 260)
Query Neighborhood Hits	177	Target Neighborhood Hits	676	Shared Neighborhood Hits	42
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

AUTS2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.059440 (rank : 395)
Query Neighborhood Hits	177	Target Neighborhood Hits	342	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

BASP_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.057195 (rank : 414)
Query Neighborhood Hits	177	Target Neighborhood Hits	321	Shared Neighborhood Hits	27
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BASP_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.059280 (rank : 400)
Query Neighborhood Hits	177	Target Neighborhood Hits	260	Shared Neighborhood Hits	20
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BCAR1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.069705 (rank : 252)
Query Neighborhood Hits	177	Target Neighborhood Hits	554	Shared Neighborhood Hits	63
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.062103 (rank : 341)
Query Neighborhood Hits	177	Target Neighborhood Hits	438	Shared Neighborhood Hits	55
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR3_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.130849 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.128519 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	127	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BLK_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.113130 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	994	Shared Neighborhood Hits	74
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.115451 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	992	Shared Neighborhood Hits	76
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BRAF1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.052818 (rank : 474)
Query Neighborhood Hits	177	Target Neighborhood Hits	883	Shared Neighborhood Hits	35
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRD4_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.054961 (rank : 448)
Query Neighborhood Hits	177	Target Neighborhood Hits	845	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CCNK_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.076035 (rank : 212)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	33
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

CD2AP_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.090653 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	315	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.094278 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHIN_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.068801 (rank : 258)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	52
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.072608 (rank : 229)
Query Neighborhood Hits	177	Target Neighborhood Hits	229	Shared Neighborhood Hits	58
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.058414 (rank : 407)
Query Neighborhood Hits	177	Target Neighborhood Hits	220	Shared Neighborhood Hits	49
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.054410 (rank : 455)
Query Neighborhood Hits	177	Target Neighborhood Hits	374	Shared Neighborhood Hits	34
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CJ078_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.072529 (rank : 231)
Query Neighborhood Hits	177	Target Neighborhood Hits	559	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CN032_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.077140 (rank : 202)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CN155_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.077098 (rank : 204)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	31
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CPSF6_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.066090 (rank : 286)
Query Neighborhood Hits	177	Target Neighborhood Hits	359	Shared Neighborhood Hits	31
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.067243 (rank : 275)
Query Neighborhood Hits	177	Target Neighborhood Hits	356	Shared Neighborhood Hits	31
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CRKL_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.219519 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	78
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CS016_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.051074 (rank : 502)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	34
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

CSF1R_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.063113 (rank : 322)
Query Neighborhood Hits	177	Target Neighborhood Hits	943	Shared Neighborhood Hits	33
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.061223 (rank : 357)
Query Neighborhood Hits	177	Target Neighborhood Hits	983	Shared Neighborhood Hits	33
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSK_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.115423 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	80
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.115168 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	80
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.052548 (rank : 480)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.066532 (rank : 283)
Query Neighborhood Hits	177	Target Neighborhood Hits	244	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.067335 (rank : 273)
Query Neighborhood Hits	177	Target Neighborhood Hits	306	Shared Neighborhood Hits	43
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDR1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.065510 (rank : 289)
Query Neighborhood Hits	177	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.065577 (rank : 288)
Query Neighborhood Hits	177	Target Neighborhood Hits	818	Shared Neighborhood Hits	35
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.062345 (rank : 334)
Query Neighborhood Hits	177	Target Neighborhood Hits	818	Shared Neighborhood Hits	33
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.062269 (rank : 337)
Query Neighborhood Hits	177	Target Neighborhood Hits	813	Shared Neighborhood Hits	33
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DNMBP_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.070182 (rank : 249)
Query Neighborhood Hits	177	Target Neighborhood Hits	413	Shared Neighborhood Hits	47
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.065241 (rank : 295)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ECM1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.052101 (rank : 486)
Query Neighborhood Hits	177	Target Neighborhood Hits	182	Shared Neighborhood Hits	17
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

EFS_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.076097 (rank : 211)
Query Neighborhood Hits	177	Target Neighborhood Hits	348	Shared Neighborhood Hits	49
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EGFR_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.061574 (rank : 349)
Query Neighborhood Hits	177	Target Neighborhood Hits	939	Shared Neighborhood Hits	33
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.061547 (rank : 352)
Query Neighborhood Hits	177	Target Neighborhood Hits	927	Shared Neighborhood Hits	33
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ENAH_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.072278 (rank : 234)
Query Neighborhood Hits	177	Target Neighborhood Hits	919	Shared Neighborhood Hits	52
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.061755 (rank : 346)
Query Neighborhood Hits	177	Target Neighborhood Hits	997	Shared Neighborhood Hits	35
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.062087 (rank : 342)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	38
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.061463 (rank : 353)
Query Neighborhood Hits	177	Target Neighborhood Hits	1021	Shared Neighborhood Hits	38
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.061707 (rank : 348)
Query Neighborhood Hits	177	Target Neighborhood Hits	1020	Shared Neighborhood Hits	38
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.059378 (rank : 399)
Query Neighborhood Hits	177	Target Neighborhood Hits	1005	Shared Neighborhood Hits	33
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.059397 (rank : 398)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	33
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.060644 (rank : 378)
Query Neighborhood Hits	177	Target Neighborhood Hits	975	Shared Neighborhood Hits	35
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.060653 (rank : 376)
Query Neighborhood Hits	177	Target Neighborhood Hits	982	Shared Neighborhood Hits	35
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.060703 (rank : 373)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	38
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.062922 (rank : 326)
Query Neighborhood Hits	177	Target Neighborhood Hits	950	Shared Neighborhood Hits	37
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.063540 (rank : 313)
Query Neighborhood Hits	177	Target Neighborhood Hits	959	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.063312 (rank : 318)
Query Neighborhood Hits	177	Target Neighborhood Hits	946	Shared Neighborhood Hits	36
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.059503 (rank : 394)
Query Neighborhood Hits	177	Target Neighborhood Hits	1053	Shared Neighborhood Hits	37
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.059432 (rank : 396)
Query Neighborhood Hits	177	Target Neighborhood Hits	1025	Shared Neighborhood Hits	37
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.060770 (rank : 368)
Query Neighborhood Hits	177	Target Neighborhood Hits	956	Shared Neighborhood Hits	37
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.060737 (rank : 371)
Query Neighborhood Hits	177	Target Neighborhood Hits	969	Shared Neighborhood Hits	37
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.064898 (rank : 297)
Query Neighborhood Hits	177	Target Neighborhood Hits	960	Shared Neighborhood Hits	35
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.059865 (rank : 392)
Query Neighborhood Hits	177	Target Neighborhood Hits	988	Shared Neighborhood Hits	37
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.060650 (rank : 377)
Query Neighborhood Hits	177	Target Neighborhood Hits	983	Shared Neighborhood Hits	37
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.060678 (rank : 374)
Query Neighborhood Hits	177	Target Neighborhood Hits	982	Shared Neighborhood Hits	37
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.061020 (rank : 363)
Query Neighborhood Hits	177	Target Neighborhood Hits	996	Shared Neighborhood Hits	37
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.061086 (rank : 360)
Query Neighborhood Hits	177	Target Neighborhood Hits	996	Shared Neighborhood Hits	37
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.061013 (rank : 364)
Query Neighborhood Hits	177	Target Neighborhood Hits	1056	Shared Neighborhood Hits	37
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.060668 (rank : 375)
Query Neighborhood Hits	177	Target Neighborhood Hits	1013	Shared Neighborhood Hits	37
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.063729 (rank : 307)
Query Neighborhood Hits	177	Target Neighborhood Hits	912	Shared Neighborhood Hits	36
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.063546 (rank : 312)
Query Neighborhood Hits	177	Target Neighborhood Hits	906	Shared Neighborhood Hits	36
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.064762 (rank : 298)
Query Neighborhood Hits	177	Target Neighborhood Hits	1073	Shared Neighborhood Hits	44
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.064238 (rank : 301)
Query Neighborhood Hits	177	Target Neighborhood Hits	918	Shared Neighborhood Hits	39
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.063923 (rank : 305)
Query Neighborhood Hits	177	Target Neighborhood Hits	918	Shared Neighborhood Hits	32
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.063649 (rank : 309)
Query Neighborhood Hits	177	Target Neighborhood Hits	898	Shared Neighborhood Hits	33
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.063328 (rank : 316)
Query Neighborhood Hits	177	Target Neighborhood Hits	910	Shared Neighborhood Hits	34
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.064748 (rank : 299)
Query Neighborhood Hits	177	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.058082 (rank : 411)
Query Neighborhood Hits	177	Target Neighborhood Hits	143	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.061223 (rank : 358)
Query Neighborhood Hits	177	Target Neighborhood Hits	193	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.060623 (rank : 379)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	35
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.074947 (rank : 215)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.069975 (rank : 250)
Query Neighborhood Hits	177	Target Neighborhood Hits	168	Shared Neighborhood Hits	37
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FAK1_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.062811 (rank : 329)
Query Neighborhood Hits	177	Target Neighborhood Hits	850	Shared Neighborhood Hits	33
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.062847 (rank : 328)
Query Neighborhood Hits	177	Target Neighborhood Hits	850	Shared Neighborhood Hits	34
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.065395 (rank : 292)
Query Neighborhood Hits	177	Target Neighborhood Hits	847	Shared Neighborhood Hits	34
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.065067 (rank : 296)
Query Neighborhood Hits	177	Target Neighborhood Hits	851	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FES_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.082755 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	978	Shared Neighborhood Hits	65
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.077115 (rank : 203)
Query Neighborhood Hits	177	Target Neighborhood Hits	980	Shared Neighborhood Hits	59
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.056003 (rank : 436)
Query Neighborhood Hits	177	Target Neighborhood Hits	1069	Shared Neighborhood Hits	34
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.056063 (rank : 435)
Query Neighborhood Hits	177	Target Neighborhood Hits	1068	Shared Neighborhood Hits	34
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.056287 (rank : 431)
Query Neighborhood Hits	177	Target Neighborhood Hits	1062	Shared Neighborhood Hits	33
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.056533 (rank : 428)
Query Neighborhood Hits	177	Target Neighborhood Hits	1062	Shared Neighborhood Hits	33
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.056633 (rank : 426)
Query Neighborhood Hits	177	Target Neighborhood Hits	1042	Shared Neighborhood Hits	33
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.056319 (rank : 430)
Query Neighborhood Hits	177	Target Neighborhood Hits	1059	Shared Neighborhood Hits	33
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.058317 (rank : 409)
Query Neighborhood Hits	177	Target Neighborhood Hits	1037	Shared Neighborhood Hits	33
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.059637 (rank : 393)
Query Neighborhood Hits	177	Target Neighborhood Hits	1026	Shared Neighborhood Hits	33
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.063340 (rank : 315)
Query Neighborhood Hits	177	Target Neighborhood Hits	843	Shared Neighborhood Hits	33
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.063605 (rank : 311)
Query Neighborhood Hits	177	Target Neighborhood Hits	847	Shared Neighborhood Hits	33
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FMN1A_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.053641 (rank : 464)
Query Neighborhood Hits	177	Target Neighborhood Hits	423	Shared Neighborhood Hits	33
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.052745 (rank : 477)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	33
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

FRK_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.120772 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	1058	Shared Neighborhood Hits	85
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYB_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.079961 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	194	Shared Neighborhood Hits	19
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GGN_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.076926 (rank : 207)
Query Neighborhood Hits	177	Target Neighborhood Hits	269	Shared Neighborhood Hits	29
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GGN_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.070241 (rank : 247)
Query Neighborhood Hits	177	Target Neighborhood Hits	311	Shared Neighborhood Hits	36
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRAP2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.215168 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	304	Shared Neighborhood Hits	72
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.212315 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	71
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB10_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.135454 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	147	Shared Neighborhood Hits	62
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.135053 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	63
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.168774 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	65
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.151209 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	72
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GSCR1_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.058005 (rank : 412)
Query Neighborhood Hits	177	Target Neighborhood Hits	674	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

GUC2C_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.054836 (rank : 450)
Query Neighborhood Hits	177	Target Neighborhood Hits	624	Shared Neighborhood Hits	32
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.050918 (rank : 505)
Query Neighborhood Hits	177	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.051291 (rank : 496)
Query Neighborhood Hits	177	Target Neighborhood Hits	692	Shared Neighborhood Hits	31
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.056872 (rank : 418)
Query Neighborhood Hits	177	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

HCLS1_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.088856 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	358	Shared Neighborhood Hits	58
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.085342 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	52
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HSH2D_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.145498 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	159	Shared Neighborhood Hits	65
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.120767 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	49
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.074316 (rank : 223)
Query Neighborhood Hits	177	Target Neighborhood Hits	688	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.068180 (rank : 267)
Query Neighborhood Hits	177	Target Neighborhood Hits	1024	Shared Neighborhood Hits	65
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IGF1R_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.063196 (rank : 319)
Query Neighborhood Hits	177	Target Neighborhood Hits	977	Shared Neighborhood Hits	33
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.063320 (rank : 317)
Query Neighborhood Hits	177	Target Neighborhood Hits	973	Shared Neighborhood Hits	33
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ILK1_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.054663 (rank : 451)
Query Neighborhood Hits	177	Target Neighborhood Hits	857	Shared Neighborhood Hits	33
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.054008 (rank : 461)
Query Neighborhood Hits	177	Target Neighborhood Hits	848	Shared Neighborhood Hits	33
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.055149 (rank : 444)
Query Neighborhood Hits	177	Target Neighborhood Hits	858	Shared Neighborhood Hits	34
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.063131 (rank : 321)
Query Neighborhood Hits	177	Target Neighborhood Hits	950	Shared Neighborhood Hits	35
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.062956 (rank : 324)
Query Neighborhood Hits	177	Target Neighborhood Hits	961	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.061966 (rank : 344)
Query Neighborhood Hits	177	Target Neighborhood Hits	963	Shared Neighborhood Hits	33
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.061727 (rank : 347)
Query Neighborhood Hits	177	Target Neighborhood Hits	968	Shared Neighborhood Hits	34
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK3_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.051936 (rank : 490)
Query Neighborhood Hits	177	Target Neighborhood Hits	628	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ITSN1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.071022 (rank : 241)
Query Neighborhood Hits	177	Target Neighborhood Hits	1757	Shared Neighborhood Hits	76
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.069311 (rank : 255)
Query Neighborhood Hits	177	Target Neighborhood Hits	1669	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.072012 (rank : 237)
Query Neighborhood Hits	177	Target Neighborhood Hits	1173	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.068918 (rank : 257)
Query Neighborhood Hits	177	Target Neighborhood Hits	1371	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JAK1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.060088 (rank : 388)
Query Neighborhood Hits	177	Target Neighborhood Hits	858	Shared Neighborhood Hits	37
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.060734 (rank : 372)
Query Neighborhood Hits	177	Target Neighborhood Hits	854	Shared Neighborhood Hits	37
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.055366 (rank : 441)
Query Neighborhood Hits	177	Target Neighborhood Hits	847	Shared Neighborhood Hits	34
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.055693 (rank : 440)
Query Neighborhood Hits	177	Target Neighborhood Hits	839	Shared Neighborhood Hits	34
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.057154 (rank : 416)
Query Neighborhood Hits	177	Target Neighborhood Hits	827	Shared Neighborhood Hits	33
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.054879 (rank : 449)
Query Neighborhood Hits	177	Target Neighborhood Hits	821	Shared Neighborhood Hits	33
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KIT_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.060371 (rank : 382)
Query Neighborhood Hits	177	Target Neighborhood Hits	953	Shared Neighborhood Hits	33
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.060754 (rank : 369)
Query Neighborhood Hits	177	Target Neighborhood Hits	949	Shared Neighborhood Hits	33
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.051653 (rank : 493)
Query Neighborhood Hits	177	Target Neighborhood Hits	867	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.051038 (rank : 503)
Query Neighborhood Hits	177	Target Neighborhood Hits	870	Shared Neighborhood Hits	33
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.052448 (rank : 481)
Query Neighborhood Hits	177	Target Neighborhood Hits	920	Shared Neighborhood Hits	45
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.100122 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	901	Shared Neighborhood Hits	74
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.100861 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	944	Shared Neighborhood Hits	76
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAD1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.063640 (rank : 310)
Query Neighborhood Hits	177	Target Neighborhood Hits	441	Shared Neighborhood Hits	28
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LASP1_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.066616 (rank : 282)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	37
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.065384 (rank : 293)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	37
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LCK_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.117835 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	987	Shared Neighborhood Hits	77
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.117221 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	981	Shared Neighborhood Hits	79
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LNK_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.150175 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	151	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.153800 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	58
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LTK_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.068328 (rank : 265)
Query Neighborhood Hits	177	Target Neighborhood Hits	774	Shared Neighborhood Hits	33
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.068257 (rank : 266)
Query Neighborhood Hits	177	Target Neighborhood Hits	770	Shared Neighborhood Hits	34
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K10_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.061280 (rank : 356)
Query Neighborhood Hits	177	Target Neighborhood Hits	1071	Shared Neighborhood Hits	56
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.069942 (rank : 251)
Query Neighborhood Hits	177	Target Neighborhood Hits	1136	Shared Neighborhood Hits	70
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.050599 (rank : 510)
Query Neighborhood Hits	177	Target Neighborhood Hits	940	Shared Neighborhood Hits	44
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.050002 (rank : 516)
Query Neighborhood Hits	177	Target Neighborhood Hits	957	Shared Neighborhood Hits	42
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K9_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.061550 (rank : 351)
Query Neighborhood Hits	177	Target Neighborhood Hits	1123	Shared Neighborhood Hits	62
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.063025 (rank : 323)
Query Neighborhood Hits	177	Target Neighborhood Hits	1087	Shared Neighborhood Hits	53
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MATK_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.105390 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	954	Shared Neighborhood Hits	81
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.104248 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	952	Shared Neighborhood Hits	80
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MBD6_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.102335 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	349	Shared Neighborhood Hits	36
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MERTK_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.062855 (rank : 327)
Query Neighborhood Hits	177	Target Neighborhood Hits	988	Shared Neighborhood Hits	35
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.062194 (rank : 338)
Query Neighborhood Hits	177	Target Neighborhood Hits	974	Shared Neighborhood Hits	33
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.060579 (rank : 380)
Query Neighborhood Hits	177	Target Neighborhood Hits	831	Shared Neighborhood Hits	33
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.060897 (rank : 367)
Query Neighborhood Hits	177	Target Neighborhood Hits	844	Shared Neighborhood Hits	32
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MISS_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.061072 (rank : 362)
Query Neighborhood Hits	177	Target Neighborhood Hits	444	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MLKL_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.051958 (rank : 489)
Query Neighborhood Hits	177	Target Neighborhood Hits	600	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.051723 (rank : 492)
Query Neighborhood Hits	177	Target Neighborhood Hits	707	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLL2_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.067632 (rank : 270)
Query Neighborhood Hits	177	Target Neighborhood Hits	1788	Shared Neighborhood Hits	66
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLTK_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.052787 (rank : 476)
Query Neighborhood Hits	177	Target Neighborhood Hits	911	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.052873 (rank : 469)
Query Neighborhood Hits	177	Target Neighborhood Hits	874	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.051088 (rank : 501)
Query Neighborhood Hits	177	Target Neighborhood Hits	829	Shared Neighborhood Hits	33
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.050823 (rank : 507)
Query Neighborhood Hits	177	Target Neighborhood Hits	833	Shared Neighborhood Hits	33
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MUC2_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.050905 (rank : 506)
Query Neighborhood Hits	177	Target Neighborhood Hits	906	Shared Neighborhood Hits	43
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MUC7_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.058840 (rank : 403)
Query Neighborhood Hits	177	Target Neighborhood Hits	538	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MUSK_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.058195 (rank : 410)
Query Neighborhood Hits	177	Target Neighborhood Hits	1074	Shared Neighborhood Hits	33
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.058365 (rank : 408)
Query Neighborhood Hits	177	Target Neighborhood Hits	1057	Shared Neighborhood Hits	33
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NACAM_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.050054 (rank : 514)
Query Neighborhood Hits	177	Target Neighborhood Hits	1866	Shared Neighborhood Hits	71
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCF1_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.074462 (rank : 221)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.078030 (rank : 199)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.074879 (rank : 217)
Query Neighborhood Hits	177	Target Neighborhood Hits	229	Shared Neighborhood Hits	34
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCOA6_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.065766 (rank : 287)
Query Neighborhood Hits	177	Target Neighborhood Hits	1076	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NEBL_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.063167 (rank : 320)
Query Neighborhood Hits	177	Target Neighborhood Hits	457	Shared Neighborhood Hits	42
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOLC1_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.051992 (rank : 487)
Query Neighborhood Hits	177	Target Neighborhood Hits	452	Shared Neighborhood Hits	32
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NOXO1_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.051147 (rank : 500)
Query Neighborhood Hits	177	Target Neighborhood Hits	114	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.096691 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.108848 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NSD1_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.056091 (rank : 433)
Query Neighborhood Hits	177	Target Neighborhood Hits	472	Shared Neighborhood Hits	29
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

NTRK1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.064019 (rank : 304)
Query Neighborhood Hits	177	Target Neighborhood Hits	1023	Shared Neighborhood Hits	33
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.060100 (rank : 387)
Query Neighborhood Hits	177	Target Neighborhood Hits	1081	Shared Neighborhood Hits	33
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.060054 (rank : 389)
Query Neighborhood Hits	177	Target Neighborhood Hits	1088	Shared Neighborhood Hits	33
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.062797 (rank : 330)
Query Neighborhood Hits	177	Target Neighborhood Hits	1115	Shared Neighborhood Hits	33
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OSTF1_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.082062 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	466	Shared Neighborhood Hits	42
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.078528 (rank : 195)
Query Neighborhood Hits	177	Target Neighborhood Hits	467	Shared Neighborhood Hits	42
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN1_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.072983 (rank : 226)
Query Neighborhood Hits	177	Target Neighborhood Hits	320	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.072118 (rank : 235)
Query Neighborhood Hits	177	Target Neighborhood Hits	283	Shared Neighborhood Hits	40
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.077725 (rank : 200)
Query Neighborhood Hits	177	Target Neighborhood Hits	339	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.077604 (rank : 201)
Query Neighborhood Hits	177	Target Neighborhood Hits	382	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.066983 (rank : 280)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.066410 (rank : 284)
Query Neighborhood Hits	177	Target Neighborhood Hits	380	Shared Neighborhood Hits	43
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCQAP_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.052856 (rank : 470)
Query Neighborhood Hits	177	Target Neighborhood Hits	549	Shared Neighborhood Hits	27
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PEX13_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.056527 (rank : 429)
Query Neighborhood Hits	177	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PGFRA_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.061556 (rank : 350)
Query Neighborhood Hits	177	Target Neighborhood Hits	980	Shared Neighborhood Hits	33
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.061766 (rank : 345)
Query Neighborhood Hits	177	Target Neighborhood Hits	975	Shared Neighborhood Hits	33
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.062278 (rank : 336)
Query Neighborhood Hits	177	Target Neighborhood Hits	962	Shared Neighborhood Hits	33
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.062114 (rank : 340)
Query Neighborhood Hits	177	Target Neighborhood Hits	960	Shared Neighborhood Hits	33
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PHAR2_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.052742 (rank : 478)
Query Neighborhood Hits	177	Target Neighborhood Hits	208	Shared Neighborhood Hits	22
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

PLCB3_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.051279 (rank : 497)
Query Neighborhood Hits	177	Target Neighborhood Hits	445	Shared Neighborhood Hits	11
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB3_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.052366 (rank : 484)
Query Neighborhood Hits	177	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCD1_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.074448 (rank : 222)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.074913 (rank : 216)
Query Neighborhood Hits	177	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PPIP1_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.088059 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	50
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.082289 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	377	Shared Neighborhood Hits	49
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRB3_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.078170 (rank : 197)
Query Neighborhood Hits	177	Target Neighborhood Hits	318	Shared Neighborhood Hits	33
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.127769 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	330	Shared Neighborhood Hits	39
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRCC_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.052835 (rank : 472)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

PRP1_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.104402 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	35
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.080780 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	34
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRR12_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.086976 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	460	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

PRR8_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.055970 (rank : 438)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

PS1C2_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.104638 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

PS1C2_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.080487 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

PTK6_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.103749 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	1020	Shared Neighborhood Hits	73
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK7_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.056614 (rank : 427)
Query Neighborhood Hits	177	Target Neighborhood Hits	1103	Shared Neighborhood Hits	32
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN23_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.051265 (rank : 498)
Query Neighborhood Hits	177	Target Neighborhood Hits	646	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.054257 (rank : 458)
Query Neighborhood Hits	177	Target Neighborhood Hits	726	Shared Neighborhood Hits	38
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

RAF1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.053013 (rank : 467)
Query Neighborhood Hits	177	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.052736 (rank : 479)
Query Neighborhood Hits	177	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAPH1_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.089450 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	593	Shared Neighborhood Hits	54
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RERE_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.056262 (rank : 432)
Query Neighborhood Hits	177	Target Neighborhood Hits	779	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RERE_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.058723 (rank : 404)
Query Neighborhood Hits	177	Target Neighborhood Hits	785	Shared Neighborhood Hits	46
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RET_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.060981 (rank : 366)
Query Neighborhood Hits	177	Target Neighborhood Hits	873	Shared Neighborhood Hits	33
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.060450 (rank : 381)
Query Neighborhood Hits	177	Target Neighborhood Hits	884	Shared Neighborhood Hits	33
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RHG04_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.050512 (rank : 512)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIPK1_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.050993 (rank : 504)
Query Neighborhood Hits	177	Target Neighborhood Hits	891	Shared Neighborhood Hits	35
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.052131 (rank : 485)
Query Neighborhood Hits	177	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.050612 (rank : 509)
Query Neighborhood Hits	177	Target Neighborhood Hits	774	Shared Neighborhood Hits	32
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.050818 (rank : 508)
Query Neighborhood Hits	177	Target Neighborhood Hits	776	Shared Neighborhood Hits	33
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.050595 (rank : 511)
Query Neighborhood Hits	177	Target Neighborhood Hits	867	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RNC_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.055834 (rank : 439)
Query Neighborhood Hits	177	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

RON_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.061076 (rank : 361)
Query Neighborhood Hits	177	Target Neighborhood Hits	842	Shared Neighborhood Hits	32
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.062074 (rank : 343)
Query Neighborhood Hits	177	Target Neighborhood Hits	836	Shared Neighborhood Hits	32
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.059992 (rank : 390)
Query Neighborhood Hits	177	Target Neighborhood Hits	1018	Shared Neighborhood Hits	33
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.060294 (rank : 383)
Query Neighborhood Hits	177	Target Neighborhood Hits	1025	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.060997 (rank : 365)
Query Neighborhood Hits	177	Target Neighborhood Hits	1014	Shared Neighborhood Hits	33
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.062604 (rank : 333)
Query Neighborhood Hits	177	Target Neighborhood Hits	1000	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.067291 (rank : 274)
Query Neighborhood Hits	177	Target Neighborhood Hits	907	Shared Neighborhood Hits	33
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC1_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.054595 (rank : 452)
Query Neighborhood Hits	177	Target Neighborhood Hits	226	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RYK_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.067563 (rank : 271)
Query Neighborhood Hits	177	Target Neighborhood Hits	701	Shared Neighborhood Hits	31
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.067102 (rank : 279)
Query Neighborhood Hits	177	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SET1A_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.067224 (rank : 276)
Query Neighborhood Hits	177	Target Neighborhood Hits	690	Shared Neighborhood Hits	47
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SF3A2_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.069686 (rank : 254)
Query Neighborhood Hits	177	Target Neighborhood Hits	263	Shared Neighborhood Hits	28
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SF3A2_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.059018 (rank : 401)
Query Neighborhood Hits	177	Target Neighborhood Hits	247	Shared Neighborhood Hits	27
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SFPQ_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.063918 (rank : 306)
Query Neighborhood Hits	177	Target Neighborhood Hits	986	Shared Neighborhood Hits	47
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SGIP1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.058506 (rank : 406)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SH22A_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.121399 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.125938 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.158902 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.109995 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	326	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.127543 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	188	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.128633 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G1_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.051972 (rank : 488)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.053636 (rank : 465)
Query Neighborhood Hits	177	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.055992 (rank : 437)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	39
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.055124 (rank : 446)
Query Neighborhood Hits	177	Target Neighborhood Hits	319	Shared Neighborhood Hits	38
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.057438 (rank : 413)
Query Neighborhood Hits	177	Target Neighborhood Hits	236	Shared Neighborhood Hits	37
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.097025 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	341	Shared Neighborhood Hits	47
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.095697 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.068679 (rank : 261)
Query Neighborhood Hits	177	Target Neighborhood Hits	1041	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHB_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.168395 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.169504 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.152490 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	69
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.153199 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	68
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.188132 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.202421 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.204750 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.212994 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.217385 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	136	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SMR1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.055144 (rank : 445)
Query Neighborhood Hits	177	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

SMR3A_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.052948 (rank : 468)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

SOCS1_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.100400 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	79	Shared Neighborhood Hits	33
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.105074 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	82	Shared Neighborhood Hits	33
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS3_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.117620 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.117779 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	36
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS4_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.078106 (rank : 198)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.078909 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS5_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.086632 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	91	Shared Neighborhood Hits	40
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.086023 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	39
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SOCS7_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.170088 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	154	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.086391 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.079972 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.084417 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.086709 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	409	Shared Neighborhood Hits	53
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.076414 (rank : 209)
Query Neighborhood Hits	177	Target Neighborhood Hits	269	Shared Neighborhood Hits	39
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.074271 (rank : 224)
Query Neighborhood Hits	177	Target Neighborhood Hits	292	Shared Neighborhood Hits	41
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP2_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.050205 (rank : 513)
Query Neighborhood Hits	177	Target Neighborhood Hits	331	Shared Neighborhood Hits	44
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.107447 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	946	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRRM1_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.109200 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	690	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.096215 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	966	Shared Neighborhood Hits	59
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.065373 (rank : 294)
Query Neighborhood Hits	177	Target Neighborhood Hits	1296	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.054186 (rank : 459)
Query Neighborhood Hits	177	Target Neighborhood Hits	1470	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

STAC3_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.079865 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	33
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.080084 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	232	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.067993 (rank : 269)
Query Neighborhood Hits	177	Target Neighborhood Hits	276	Shared Neighborhood Hits	39
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.070307 (rank : 246)
Query Neighborhood Hits	177	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.079148 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	271	Shared Neighborhood Hits	39
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.081213 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	273	Shared Neighborhood Hits	41
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.085240 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.084536 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	285	Shared Neighborhood Hits	38
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.066670 (rank : 281)
Query Neighborhood Hits	177	Target Neighborhood Hits	786	Shared Neighborhood Hits	33
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.067194 (rank : 278)
Query Neighborhood Hits	177	Target Neighborhood Hits	779	Shared Neighborhood Hits	33
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TCOF_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.056868 (rank : 419)
Query Neighborhood Hits	177	Target Neighborhood Hits	471	Shared Neighborhood Hits	30
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TENS1_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.075814 (rank : 213)
Query Neighborhood Hits	177	Target Neighborhood Hits	400	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TENS4_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.068055 (rank : 268)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.070861 (rank : 243)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.062659 (rank : 332)
Query Neighborhood Hits	177	Target Neighborhood Hits	1103	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.056744 (rank : 423)
Query Neighborhood Hits	177	Target Neighborhood Hits	1333	Shared Neighborhood Hits	42
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIE1_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.056802 (rank : 421)
Query Neighborhood Hits	177	Target Neighborhood Hits	1241	Shared Neighborhood Hits	34
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.056663 (rank : 425)
Query Neighborhood Hits	177	Target Neighborhood Hits	1266	Shared Neighborhood Hits	34
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.056815 (rank : 420)
Query Neighborhood Hits	177	Target Neighborhood Hits	1192	Shared Neighborhood Hits	34
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.056752 (rank : 422)
Query Neighborhood Hits	177	Target Neighborhood Hits	1204	Shared Neighborhood Hits	34
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNK1_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.065427 (rank : 291)
Query Neighborhood Hits	177	Target Neighborhood Hits	815	Shared Neighborhood Hits	40
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.064100 (rank : 302)
Query Neighborhood Hits	177	Target Neighborhood Hits	806	Shared Neighborhood Hits	39
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TYK2_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.057131 (rank : 417)
Query Neighborhood Hits	177	Target Neighborhood Hits	841	Shared Neighborhood Hits	33
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.059961 (rank : 391)
Query Neighborhood Hits	177	Target Neighborhood Hits	995	Shared Neighborhood Hits	33
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.060121 (rank : 386)
Query Neighborhood Hits	177	Target Neighborhood Hits	1007	Shared Neighborhood Hits	33
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.061281 (rank : 355)
Query Neighborhood Hits	177	Target Neighborhood Hits	981	Shared Neighborhood Hits	34
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.060739 (rank : 370)
Query Neighborhood Hits	177	Target Neighborhood Hits	988	Shared Neighborhood Hits	33
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VAV2_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.159820 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	453	Shared Neighborhood Hits	76
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.157575 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	456	Shared Neighborhood Hits	75
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.175684 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	398	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.176452 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	404	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VGFR1_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.054395 (rank : 456)
Query Neighborhood Hits	177	Target Neighborhood Hits	1109	Shared Neighborhood Hits	33
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.053974 (rank : 462)
Query Neighborhood Hits	177	Target Neighborhood Hits	1118	Shared Neighborhood Hits	33
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.055350 (rank : 442)
Query Neighborhood Hits	177	Target Neighborhood Hits	1103	Shared Neighborhood Hits	35
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.055039 (rank : 447)
Query Neighborhood Hits	177	Target Neighborhood Hits	1089	Shared Neighborhood Hits	33
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.056063 (rank : 434)
Query Neighborhood Hits	177	Target Neighborhood Hits	1037	Shared Neighborhood Hits	33
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.056739 (rank : 424)
Query Neighborhood Hits	177	Target Neighborhood Hits	1056	Shared Neighborhood Hits	33
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VINEX_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.086571 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	270	Shared Neighborhood Hits	45
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.085241 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	286	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WASF1_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.063354 (rank : 314)
Query Neighborhood Hits	177	Target Neighborhood Hits	260	Shared Neighborhood Hits	27
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.062340 (rank : 335)
Query Neighborhood Hits	177	Target Neighborhood Hits	261	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

WASF2_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.054479 (rank : 453)
Query Neighborhood Hits	177	Target Neighborhood Hits	280	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WASF2_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.062937 (rank : 325)
Query Neighborhood Hits	177	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WASF4_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.058547 (rank : 405)
Query Neighborhood Hits	177	Target Neighborhood Hits	282	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

WASIP_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.121937 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	392	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WASL_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.082292 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	36
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASL_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.101066 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WBP11_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.074594 (rank : 220)
Query Neighborhood Hits	177	Target Neighborhood Hits	354	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.070449 (rank : 245)
Query Neighborhood Hits	177	Target Neighborhood Hits	362	Shared Neighborhood Hits	36
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

WBS14_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.058939 (rank : 402)
Query Neighborhood Hits	177	Target Neighborhood Hits	273	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

WIRE_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.084011 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.086371 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

YLPM1_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.066123 (rank : 285)
Query Neighborhood Hits	177	Target Neighborhood Hits	505	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZN207_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.078306 (rank : 196)
Query Neighborhood Hits	177	Target Neighborhood Hits	326	Shared Neighborhood Hits	24
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

Hits sorted by NC score

LCP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_HUMAN
NC score	0.806570 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	531	Shared Neighborhood Hits	127
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BLNK_HUMAN
NC score	0.589905 (rank : 3)	θ value	6.20254e-17 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
NC score	0.588797 (rank : 4)	θ value	1.92812e-18 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	296	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

DAPP1_HUMAN
NC score	0.390341 (rank : 5)	θ value	2.21117e-06 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.382937 (rank : 6)	θ value	8.40245e-06 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLCG1_HUMAN
NC score	0.350821 (rank : 7)	θ value	8.97725e-08 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	76
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.348209 (rank : 8)	θ value	8.97725e-08 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	76
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NCK2_HUMAN
NC score	0.341132 (rank : 9)	θ value	3.19293e-05 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.340420 (rank : 10)	θ value	1.43324e-05 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	78
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PLCG2_HUMAN
NC score	0.328333 (rank : 11)	θ value	0.000121331 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	280	Shared Neighborhood Hits	75
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

GRAP_MOUSE
NC score	0.301017 (rank : 12)	θ value	0.00175202 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	309	Shared Neighborhood Hits	77
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.299994 (rank : 13)	θ value	0.00228821 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SHC3_MOUSE
NC score	0.296398 (rank : 14)	θ value	0.00509761 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	151	Shared Neighborhood Hits	76
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SH21B_HUMAN
NC score	0.287875 (rank : 15)	θ value	0.0330416 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	57
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHC3_HUMAN
NC score	0.282521 (rank : 16)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	155	Shared Neighborhood Hits	74
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

RASA1_HUMAN
NC score	0.277785 (rank : 17)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	258	Shared Neighborhood Hits	74
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

GRB2_MOUSE
NC score	0.274468 (rank : 18)	θ value	0.0961366 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	81
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.273837 (rank : 19)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	79
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SH21B_MOUSE
NC score	0.272475 (rank : 20)	θ value	0.0736092 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHC2_MOUSE
NC score	0.264891 (rank : 21)	θ value	0.0148317 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

P85B_HUMAN
NC score	0.262767 (rank : 22)	θ value	0.0330416 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_HUMAN
NC score	0.259161 (rank : 23)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	451	Shared Neighborhood Hits	70
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_MOUSE
NC score	0.258404 (rank : 24)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	519	Shared Neighborhood Hits	81
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_MOUSE
NC score	0.257886 (rank : 25)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	401	Shared Neighborhood Hits	69
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHC2_HUMAN
NC score	0.253483 (rank : 26)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	74
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SH21A_MOUSE
NC score	0.249130 (rank : 27)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SHC1_MOUSE
NC score	0.246537 (rank : 28)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	180	Shared Neighborhood Hits	74
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SH21A_HUMAN
NC score	0.241293 (rank : 29)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

P85A_MOUSE
NC score	0.239083 (rank : 30)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	74
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHC1_HUMAN
NC score	0.237205 (rank : 31)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	72
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

CRKL_MOUSE
NC score	0.235705 (rank : 32)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	77
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

P85A_HUMAN
NC score	0.234819 (rank : 33)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	479	Shared Neighborhood Hits	72
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CRK_HUMAN
NC score	0.227453 (rank : 34)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	308	Shared Neighborhood Hits	79
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.223977 (rank : 35)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	314	Shared Neighborhood Hits	79
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.219519 (rank : 36)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	78
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SLAP2_MOUSE
NC score	0.217385 (rank : 37)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	177	Target Neighborhood Hits	136	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

GRAP2_HUMAN
NC score	0.215168 (rank : 38)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	177	Target Neighborhood Hits	304	Shared Neighborhood Hits	72
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SLAP2_HUMAN
NC score	0.212994 (rank : 39)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	177	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRAP2_MOUSE
NC score	0.212315 (rank : 40)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	71
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SOCS2_MOUSE
NC score	0.209355 (rank : 41)	θ value	0.163984 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	53
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS2_HUMAN
NC score	0.206474 (rank : 42)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	104	Shared Neighborhood Hits	53
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

PTN11_MOUSE
NC score	0.206089 (rank : 43)	θ value	0.000158464 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.206066 (rank : 44)	θ value	0.000158464 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	76
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

SLAP1_MOUSE
NC score	0.204750 (rank : 45)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP1_HUMAN
NC score	0.202421 (rank : 46)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	177	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SHE_HUMAN
NC score	0.191598 (rank : 47)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	164	Shared Neighborhood Hits	73
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
NC score	0.188132 (rank : 48)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

GRB14_MOUSE
NC score	0.187408 (rank : 49)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	149	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SOCS6_MOUSE
NC score	0.186444 (rank : 50)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	146	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_HUMAN
NC score	0.185224 (rank : 51)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	52
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

CISH_MOUSE
NC score	0.181945 (rank : 52)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CISH_HUMAN
NC score	0.181274 (rank : 53)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

VAV3_MOUSE
NC score	0.176452 (rank : 54)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	177	Target Neighborhood Hits	404	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.175684 (rank : 55)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	177	Target Neighborhood Hits	398	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PTN6_MOUSE
NC score	0.172104 (rank : 56)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SOCS7_MOUSE
NC score	0.170088 (rank : 57)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	177	Target Neighborhood Hits	154	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SHB_MOUSE
NC score	0.169504 (rank : 58)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

GRB14_HUMAN
NC score	0.168774 (rank : 59)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	65
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHB_HUMAN
NC score	0.168395 (rank : 60)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	177	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PTN6_HUMAN
NC score	0.165068 (rank : 61)	θ value	0.0330416 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	234	Shared Neighborhood Hits	72
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

VAV_HUMAN
NC score	0.164645 (rank : 62)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	452	Shared Neighborhood Hits	72
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

APS_HUMAN
NC score	0.161648 (rank : 63)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	177	Target Neighborhood Hits	162	Shared Neighborhood Hits	59
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

VAV2_HUMAN
NC score	0.159820 (rank : 64)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	177	Target Neighborhood Hits	453	Shared Neighborhood Hits	76
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SH24A_HUMAN
NC score	0.158902 (rank : 65)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	177	Target Neighborhood Hits	455	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

VAV2_MOUSE
NC score	0.157575 (rank : 66)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	177	Target Neighborhood Hits	456	Shared Neighborhood Hits	75
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.157367 (rank : 67)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	430	Shared Neighborhood Hits	71
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

LNK_MOUSE
NC score	0.153800 (rank : 68)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	58
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

WASIP_HUMAN
NC score	0.153596 (rank : 69)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	458	Shared Neighborhood Hits	43
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SHD_MOUSE
NC score	0.153199 (rank : 70)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	68
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_HUMAN
NC score	0.152490 (rank : 71)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	177	Target Neighborhood Hits	204	Shared Neighborhood Hits	69
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

GRB7_MOUSE
NC score	0.151209 (rank : 72)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	72
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LNK_HUMAN
NC score	0.150175 (rank : 73)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	177	Target Neighborhood Hits	151	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FGR_MOUSE
NC score	0.146325 (rank : 74)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	1069	Shared Neighborhood Hits	87
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GRB7_HUMAN
NC score	0.145912 (rank : 75)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	65
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

HSH2D_HUMAN
NC score	0.145498 (rank : 76)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	177	Target Neighborhood Hits	159	Shared Neighborhood Hits	65
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

FGR_HUMAN
NC score	0.141040 (rank : 77)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	1067	Shared Neighborhood Hits	86
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BTK_HUMAN
NC score	0.141017 (rank : 78)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	1026	Shared Neighborhood Hits	80
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SRC_MOUSE
NC score	0.140780 (rank : 79)	θ value	0.000602161 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	1033	Shared Neighborhood Hits	84
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRC_HUMAN
NC score	0.140642 (rank : 80)	θ value	0.000602161 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	1058	Shared Neighborhood Hits	85
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

BTK_MOUSE
NC score	0.140533 (rank : 81)	θ value	0.0113563 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	1017	Shared Neighborhood Hits	79
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

APS_MOUSE
NC score	0.136654 (rank : 82)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	177	Target Neighborhood Hits	134	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRB10_HUMAN
NC score	0.135454 (rank : 83)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	177	Target Neighborhood Hits	147	Shared Neighborhood Hits	62
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
NC score	0.135053 (rank : 84)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	63
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

FYN_MOUSE
NC score	0.132469 (rank : 85)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	1073	Shared Neighborhood Hits	83
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SH23A_HUMAN
NC score	0.132056 (rank : 86)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

YES_MOUSE
NC score	0.131902 (rank : 87)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	1052	Shared Neighborhood Hits	83
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.131555 (rank : 88)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	1059	Shared Neighborhood Hits	82
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BCAR3_HUMAN
NC score	0.130849 (rank : 89)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	177	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

FYN_HUMAN
NC score	0.130683 (rank : 90)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	1078	Shared Neighborhood Hits	84
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

TEC_HUMAN
NC score	0.130543 (rank : 91)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	1006	Shared Neighborhood Hits	78
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.130314 (rank : 92)	θ value	0.0736092 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	971	Shared Neighborhood Hits	79
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
NC score	0.129750 (rank : 93)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	980	Shared Neighborhood Hits	80
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SH2D3_MOUSE
NC score	0.128633 (rank : 94)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

BCAR3_MOUSE
NC score	0.128519 (rank : 95)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	177	Target Neighborhood Hits	127	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

PRB4S_HUMAN
NC score	0.127769 (rank : 96)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	177	Target Neighborhood Hits	330	Shared Neighborhood Hits	39
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

TEC_MOUSE
NC score	0.127762 (rank : 97)	θ value	0.125558 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	1006	Shared Neighborhood Hits	77
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SH2D3_HUMAN
NC score	0.127543 (rank : 98)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	177	Target Neighborhood Hits	188	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

HCK_HUMAN
NC score	0.127215 (rank : 99)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	1035	Shared Neighborhood Hits	79
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
NC score	0.126985 (rank : 100)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	1029	Shared Neighborhood Hits	79
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SH22A_MOUSE
NC score	0.125938 (rank : 101)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	177	Target Neighborhood Hits	179	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

BMX_HUMAN
NC score	0.125741 (rank : 102)	θ value	0.0252991 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	942	Shared Neighborhood Hits	71
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.124987 (rank : 103)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	912	Shared Neighborhood Hits	71
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

LYN_MOUSE
NC score	0.124335 (rank : 104)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	1023	Shared Neighborhood Hits	78
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.124172 (rank : 105)	θ value	0.0961366 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	1022	Shared Neighborhood Hits	78
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

WASIP_MOUSE
NC score	0.121937 (rank : 106)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	177	Target Neighborhood Hits	392	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ABL1_MOUSE
NC score	0.121788 (rank : 107)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	1178	Shared Neighborhood Hits	99
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SH22A_HUMAN
NC score	0.121399 (rank : 108)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	177	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

FYB_HUMAN
NC score	0.121282 (rank : 109)	θ value	0.0563607 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	379	Shared Neighborhood Hits	32
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

ABL1_HUMAN
NC score	0.121272 (rank : 110)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	1220	Shared Neighborhood Hits	96
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.121000 (rank : 111)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	1045	Shared Neighborhood Hits	88
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ITK_MOUSE
NC score	0.120791 (rank : 112)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	985	Shared Neighborhood Hits	72
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

FRK_HUMAN
NC score	0.120772 (rank : 113)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	177	Target Neighborhood Hits	1058	Shared Neighborhood Hits	85
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HSH2D_MOUSE
NC score	0.120767 (rank : 114)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	49
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ITK_HUMAN
NC score	0.120608 (rank : 115)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	1016	Shared Neighborhood Hits	76
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LCK_HUMAN
NC score	0.117835 (rank : 116)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	177	Target Neighborhood Hits	987	Shared Neighborhood Hits	77
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SOCS3_MOUSE
NC score	0.117779 (rank : 117)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	36
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS3_HUMAN
NC score	0.117620 (rank : 118)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	177	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

PTK6_MOUSE
NC score	0.117440 (rank : 119)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	1026	Shared Neighborhood Hits	75
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

LCK_MOUSE
NC score	0.117221 (rank : 120)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	177	Target Neighborhood Hits	981	Shared Neighborhood Hits	79
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BLK_MOUSE
NC score	0.115451 (rank : 121)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	177	Target Neighborhood Hits	992	Shared Neighborhood Hits	76
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CSK_HUMAN
NC score	0.115423 (rank : 122)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	80
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.115168 (rank : 123)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	80
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

BLK_HUMAN
NC score	0.113130 (rank : 124)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	177	Target Neighborhood Hits	994	Shared Neighborhood Hits	74
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SRMS_MOUSE
NC score	0.111367 (rank : 125)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	964	Shared Neighborhood Hits	75
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SH24A_MOUSE
NC score	0.109995 (rank : 126)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	177	Target Neighborhood Hits	326	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

FER_HUMAN
NC score	0.109356 (rank : 127)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	1278	Shared Neighborhood Hits	88
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SRRM1_HUMAN
NC score	0.109200 (rank : 128)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	177	Target Neighborhood Hits	690	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

NPHP1_MOUSE
NC score	0.108848 (rank : 129)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SRMS_HUMAN
NC score	0.107447 (rank : 130)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	177	Target Neighborhood Hits	946	Shared Neighborhood Hits	69
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

MATK_HUMAN
NC score	0.105390 (rank : 131)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	177	Target Neighborhood Hits	954	Shared Neighborhood Hits	81
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ZAP70_MOUSE
NC score	0.105078 (rank : 132)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	905	Shared Neighborhood Hits	77
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SOCS1_MOUSE
NC score	0.105074 (rank : 133)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	177	Target Neighborhood Hits	82	Shared Neighborhood Hits	33
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

PS1C2_HUMAN
NC score	0.104638 (rank : 134)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	177	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

PRP1_HUMAN
NC score	0.104402 (rank : 135)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	35
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

MATK_MOUSE
NC score	0.104248 (rank : 136)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	177	Target Neighborhood Hits	952	Shared Neighborhood Hits	80
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PTK6_HUMAN
NC score	0.103749 (rank : 137)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	177	Target Neighborhood Hits	1020	Shared Neighborhood Hits	73
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

ZAP70_HUMAN
NC score	0.103296 (rank : 138)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	893	Shared Neighborhood Hits	78
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MBD6_HUMAN
NC score	0.102335 (rank : 139)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	177	Target Neighborhood Hits	349	Shared Neighborhood Hits	36
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

WASL_MOUSE
NC score	0.101066 (rank : 140)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	177	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

KSYK_MOUSE
NC score	0.100861 (rank : 141)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	177	Target Neighborhood Hits	944	Shared Neighborhood Hits	76
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SOCS1_HUMAN
NC score	0.100400 (rank : 142)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	177	Target Neighborhood Hits	79	Shared Neighborhood Hits	33
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

KSYK_HUMAN
NC score	0.100122 (rank : 143)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	177	Target Neighborhood Hits	901	Shared Neighborhood Hits	74
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

BAT2_MOUSE
NC score	0.099834 (rank : 144)	θ value	0.21417 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	947	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

PRG4_HUMAN
NC score	0.099705 (rank : 145)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	764	Shared Neighborhood Hits	42
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

EFS_MOUSE
NC score	0.097939 (rank : 146)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	54
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SH3K1_HUMAN
NC score	0.097025 (rank : 147)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	177	Target Neighborhood Hits	341	Shared Neighborhood Hits	47
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NPHP1_HUMAN
NC score	0.096691 (rank : 148)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SRRM1_MOUSE
NC score	0.096215 (rank : 149)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	177	Target Neighborhood Hits	966	Shared Neighborhood Hits	59
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SH3K1_MOUSE
NC score	0.095697 (rank : 150)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.094278 (rank : 151)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ABI2_HUMAN
NC score	0.093887 (rank : 152)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CD2AP_HUMAN
NC score	0.090653 (rank : 153)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	177	Target Neighborhood Hits	315	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

MLL4_HUMAN
NC score	0.090593 (rank : 154)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	722	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

RAPH1_HUMAN
NC score	0.089450 (rank : 155)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	177	Target Neighborhood Hits	593	Shared Neighborhood Hits	54
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

HCLS1_HUMAN
NC score	0.088856 (rank : 156)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	177	Target Neighborhood Hits	358	Shared Neighborhood Hits	58
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PPIP1_HUMAN
NC score	0.088059 (rank : 157)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	177	Target Neighborhood Hits	389	Shared Neighborhood Hits	50
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PRR12_HUMAN
NC score	0.086976 (rank : 158)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	177	Target Neighborhood Hits	460	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SRBS1_MOUSE
NC score	0.086709 (rank : 159)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	177	Target Neighborhood Hits	409	Shared Neighborhood Hits	53
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SOCS5_HUMAN
NC score	0.086632 (rank : 160)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	177	Target Neighborhood Hits	91	Shared Neighborhood Hits	40
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

VINEX_HUMAN
NC score	0.086571 (rank : 161)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	177	Target Neighborhood Hits	270	Shared Neighborhood Hits	45
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SPN90_HUMAN
NC score	0.086391 (rank : 162)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

WIRE_MOUSE
NC score	0.086371 (rank : 163)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

PRG4_MOUSE
NC score	0.086096 (rank : 164)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	624	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SOCS5_MOUSE
NC score	0.086023 (rank : 165)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	39
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

HCLS1_MOUSE
NC score	0.085342 (rank : 166)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	52
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

VINEX_MOUSE
NC score	0.085241 (rank : 167)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	177	Target Neighborhood Hits	286	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

STAM2_HUMAN
NC score	0.085240 (rank : 168)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	177	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ZCH14_HUMAN
NC score	0.085067 (rank : 169)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WYQ9, O60324, Q9UFP0	Gene names	ZCCHC14, KIAA0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

STAM2_MOUSE
NC score	0.084536 (rank : 170)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	177	Target Neighborhood Hits	285	Shared Neighborhood Hits	38
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SRBS1_HUMAN
NC score	0.084417 (rank : 171)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

WIRE_HUMAN
NC score	0.084011 (rank : 172)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	177	Target Neighborhood Hits	329	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

FES_HUMAN
NC score	0.082755 (rank : 173)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	177	Target Neighborhood Hits	978	Shared Neighborhood Hits	65
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ZCH14_MOUSE
NC score	0.082429 (rank : 174)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VIG0, Q80TX3, Q91VU4	Gene names	Zcchc14, Kiaa0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

WASL_HUMAN
NC score	0.082292 (rank : 175)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	36
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

PPIP1_MOUSE
NC score	0.082289 (rank : 176)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	177	Target Neighborhood Hits	377	Shared Neighborhood Hits	49
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

OSTF1_HUMAN
NC score	0.082062 (rank : 177)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	177	Target Neighborhood Hits	466	Shared Neighborhood Hits	42
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ABI2_MOUSE
NC score	0.081820 (rank : 178)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	266	Shared Neighborhood Hits	45
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BAT2_HUMAN
NC score	0.081489 (rank : 179)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	931	Shared Neighborhood Hits	53
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

STAM1_MOUSE
NC score	0.081213 (rank : 180)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	177	Target Neighborhood Hits	273	Shared Neighborhood Hits	41
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PRP2_MOUSE
NC score	0.080780 (rank : 181)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	34
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

ABI3_HUMAN
NC score	0.080780 (rank : 182)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PS1C2_MOUSE
NC score	0.080487 (rank : 183)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	177	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

STAC3_MOUSE
NC score	0.080084 (rank : 184)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	177	Target Neighborhood Hits	232	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SPN90_MOUSE
NC score	0.079972 (rank : 185)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	177	Target Neighborhood Hits	157	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

FYB_MOUSE
NC score	0.079961 (rank : 186)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	177	Target Neighborhood Hits	194	Shared Neighborhood Hits	19
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

STAC3_HUMAN
NC score	0.079865 (rank : 187)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	177	Target Neighborhood Hits	228	Shared Neighborhood Hits	33
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG7_MOUSE
NC score	0.079337 (rank : 188)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	177	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

WASP_HUMAN
NC score	0.079325 (rank : 189)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	195	Shared Neighborhood Hits	25
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

NCOA6_HUMAN
NC score	0.079264 (rank : 190)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	1202	Shared Neighborhood Hits	56
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

STAM1_HUMAN
NC score	0.079148 (rank : 191)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	177	Target Neighborhood Hits	271	Shared Neighborhood Hits	39
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SOCS4_MOUSE
NC score	0.078909 (rank : 192)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

ACK1_HUMAN
NC score	0.078792 (rank : 193)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

RGS3_MOUSE
NC score	0.078770 (rank : 194)	θ value	0.0330416 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	1621	Shared Neighborhood Hits	67
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

OSTF1_MOUSE
NC score	0.078528 (rank : 195)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	177	Target Neighborhood Hits	467	Shared Neighborhood Hits	42
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ZN207_HUMAN
NC score	0.078306 (rank : 196)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	177	Target Neighborhood Hits	326	Shared Neighborhood Hits	24
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

PRB3_HUMAN
NC score	0.078170 (rank : 197)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	177	Target Neighborhood Hits	318	Shared Neighborhood Hits	33
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

SOCS4_HUMAN
NC score	0.078106 (rank : 198)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

NCF1_MOUSE
NC score	0.078030 (rank : 199)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PACN2_HUMAN
NC score	0.077725 (rank : 200)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	177	Target Neighborhood Hits	339	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.077604 (rank : 201)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	177	Target Neighborhood Hits	382	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CN032_HUMAN
NC score	0.077140 (rank : 202)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	177	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

FES_MOUSE
NC score	0.077115 (rank : 203)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	177	Target Neighborhood Hits	980	Shared Neighborhood Hits	59
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

CN155_HUMAN
NC score	0.077098 (rank : 204)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	31
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

AHI1_HUMAN
NC score	0.077002 (rank : 205)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	177	Target Neighborhood Hits	537	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

3BP2_HUMAN
NC score	0.076998 (rank : 206)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

GGN_HUMAN
NC score	0.076926 (rank : 207)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	177	Target Neighborhood Hits	269	Shared Neighborhood Hits	29
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

ABI1_HUMAN
NC score	0.076644 (rank : 208)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	257	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SRC8_HUMAN
NC score	0.076414 (rank : 209)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	177	Target Neighborhood Hits	269	Shared Neighborhood Hits	39
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ARHG7_HUMAN
NC score	0.076188 (rank : 210)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	39
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

EFS_HUMAN
NC score	0.076097 (rank : 211)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	177	Target Neighborhood Hits	348	Shared Neighborhood Hits	49
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

CCNK_MOUSE
NC score	0.076035 (rank : 212)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	33
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

TENS1_HUMAN
NC score	0.075814 (rank : 213)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	177	Target Neighborhood Hits	400	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

ACK1_MOUSE
NC score	0.075370 (rank : 214)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	1080	Shared Neighborhood Hits	61
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ES8L3_HUMAN
NC score	0.074947 (rank : 215)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PLCD1_MOUSE
NC score	0.074913 (rank : 216)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	177	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

NCF2_HUMAN
NC score	0.074879 (rank : 217)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	177	Target Neighborhood Hits	229	Shared Neighborhood Hits	34
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

FMNL_HUMAN
NC score	0.074787 (rank : 218)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	529	Shared Neighborhood Hits	37
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

RGS3_HUMAN
NC score	0.074760 (rank : 219)	θ value	0.0113563 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	1375	Shared Neighborhood Hits	55
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

WBP11_HUMAN
NC score	0.074594 (rank : 220)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	177	Target Neighborhood Hits	354	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

NCF1_HUMAN
NC score	0.074462 (rank : 221)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PLCD1_HUMAN
NC score	0.074448 (rank : 222)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

IASPP_HUMAN
NC score	0.074316 (rank : 223)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	177	Target Neighborhood Hits	688	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRC8_MOUSE
NC score	0.074271 (rank : 224)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	177	Target Neighborhood Hits	292	Shared Neighborhood Hits	41
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

AB1IP_HUMAN
NC score	0.073811 (rank : 225)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	213	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

PACN1_HUMAN
NC score	0.072983 (rank : 226)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	177	Target Neighborhood Hits	320	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SFPQ_MOUSE
NC score	0.072875 (rank : 227)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

ABI3_MOUSE
NC score	0.072647 (rank : 228)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CHIN_MOUSE
NC score	0.072608 (rank : 229)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	177	Target Neighborhood Hits	229	Shared Neighborhood Hits	58
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ARHG6_HUMAN
NC score	0.072561 (rank : 230)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	177	Target Neighborhood Hits	376	Shared Neighborhood Hits	39
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CJ078_MOUSE
NC score	0.072529 (rank : 231)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	177	Target Neighborhood Hits	559	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

AB1IP_MOUSE
NC score	0.072496 (rank : 232)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	181	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ABI1_MOUSE
NC score	0.072333 (rank : 233)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	246	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ENAH_MOUSE
NC score	0.072278 (rank : 234)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	177	Target Neighborhood Hits	919	Shared Neighborhood Hits	52
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

PACN1_MOUSE
NC score	0.072118 (rank : 235)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	177	Target Neighborhood Hits	283	Shared Neighborhood Hits	40
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

HRX_HUMAN
NC score	0.072097 (rank : 236)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	825	Shared Neighborhood Hits	41
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

ITSN2_HUMAN
NC score	0.072012 (rank : 237)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	177	Target Neighborhood Hits	1173	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ASPP1_MOUSE
NC score	0.071765 (rank : 238)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	177	Target Neighborhood Hits	1244	Shared Neighborhood Hits	71
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NSD1_HUMAN
NC score	0.071192 (rank : 239)	θ value	0.0252991 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	427	Shared Neighborhood Hits	29
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

AHI1_MOUSE
NC score	0.071095 (rank : 240)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	177	Target Neighborhood Hits	496	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ITSN1_HUMAN
NC score	0.071022 (rank : 241)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	177	Target Neighborhood Hits	1757	Shared Neighborhood Hits	76
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

AATK_MOUSE
NC score	0.070866 (rank : 242)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	942	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

TENS4_MOUSE
NC score	0.070861 (rank : 243)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	177	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

FA47A_HUMAN
NC score	0.070659 (rank : 244)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	451	Shared Neighborhood Hits	34
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

WBP11_MOUSE
NC score	0.070449 (rank : 245)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	177	Target Neighborhood Hits	362	Shared Neighborhood Hits	36
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

STAC_MOUSE
NC score	0.070307 (rank : 246)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	177	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GGN_MOUSE
NC score	0.070241 (rank : 247)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	177	Target Neighborhood Hits	311	Shared Neighborhood Hits	36
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

ARHG6_MOUSE
NC score	0.070232 (rank : 248)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	177	Target Neighborhood Hits	394	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DNMBP_HUMAN
NC score	0.070182 (rank : 249)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	177	Target Neighborhood Hits	413	Shared Neighborhood Hits	47
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ES8L3_MOUSE
NC score	0.069975 (rank : 250)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	177	Target Neighborhood Hits	168	Shared Neighborhood Hits	37
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

M3K11_HUMAN
NC score	0.069942 (rank : 251)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	177	Target Neighborhood Hits	1136	Shared Neighborhood Hits	70
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

BCAR1_HUMAN
NC score	0.069705 (rank : 252)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	177	Target Neighborhood Hits	554	Shared Neighborhood Hits	63
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CEL_HUMAN
NC score	0.069694 (rank : 253)	θ value	0.00228821 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	896	Shared Neighborhood Hits	39
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SF3A2_HUMAN
NC score	0.069686 (rank : 254)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	177	Target Neighborhood Hits	263	Shared Neighborhood Hits	28
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

ITSN1_MOUSE
NC score	0.069311 (rank : 255)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	177	Target Neighborhood Hits	1669	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PCLO_HUMAN
NC score	0.069121 (rank : 256)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	2046	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ITSN2_MOUSE
NC score	0.068918 (rank : 257)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	177	Target Neighborhood Hits	1371	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CHIN_HUMAN
NC score	0.068801 (rank : 258)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	52
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

T22D4_HUMAN
NC score	0.068733 (rank : 259)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	403	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

ATN1_HUMAN
NC score	0.068708 (rank : 260)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	177	Target Neighborhood Hits	676	Shared Neighborhood Hits	42
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

SHAN1_HUMAN
NC score	0.068679 (rank : 261)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	177	Target Neighborhood Hits	1041	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SNPC4_HUMAN
NC score	0.068515 (rank : 262)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	589	Shared Neighborhood Hits	29
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

AATK_HUMAN
NC score	0.068499 (rank : 263)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	1243	Shared Neighborhood Hits	61
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

SHAN2_MOUSE
NC score	0.068448 (rank : 264)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	446	Shared Neighborhood Hits	44
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

LTK_HUMAN
NC score	0.068328 (rank : 265)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	177	Target Neighborhood Hits	774	Shared Neighborhood Hits	33
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
NC score	0.068257 (rank : 266)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	177	Target Neighborhood Hits	770	Shared Neighborhood Hits	34
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

IASPP_MOUSE
NC score	0.068180 (rank : 267)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	177	Target Neighborhood Hits	1024	Shared Neighborhood Hits	65
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TENS4_HUMAN
NC score	0.068055 (rank : 268)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

STAC_HUMAN
NC score	0.067993 (rank : 269)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	177	Target Neighborhood Hits	276	Shared Neighborhood Hits	39
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MLL2_HUMAN
NC score	0.067632 (rank : 270)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	177	Target Neighborhood Hits	1788	Shared Neighborhood Hits	66
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RYK_HUMAN
NC score	0.067563 (rank : 271)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	177	Target Neighborhood Hits	701	Shared Neighborhood Hits	31
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.067387 (rank : 272)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	177	Target Neighborhood Hits	811	Shared Neighborhood Hits	34
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

DBNL_MOUSE
NC score	0.067335 (rank : 273)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	177	Target Neighborhood Hits	306	Shared Neighborhood Hits	43
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ROS_HUMAN
NC score	0.067291 (rank : 274)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	177	Target Neighborhood Hits	907	Shared Neighborhood Hits	33
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

CPSF6_MOUSE
NC score	0.067243 (rank : 275)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	177	Target Neighborhood Hits	356	Shared Neighborhood Hits	31
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

SET1A_HUMAN
NC score	0.067224 (rank : 276)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	177	Target Neighborhood Hits	690	Shared Neighborhood Hits	47
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

ALK_HUMAN
NC score	0.067222 (rank : 277)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	177	Target Neighborhood Hits	795	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

STYK1_MOUSE
NC score	0.067194 (rank : 278)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	177	Target Neighborhood Hits	779	Shared Neighborhood Hits	33
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

RYK_MOUSE
NC score	0.067102 (rank : 279)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	177	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

PACN3_HUMAN
NC score	0.066983 (rank : 280)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	177	Target Neighborhood Hits	385	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

STYK1_HUMAN
NC score	0.066670 (rank : 281)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	177	Target Neighborhood Hits	786	Shared Neighborhood Hits	33
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

LASP1_HUMAN
NC score	0.066616 (rank : 282)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	177	Target Neighborhood Hits	293	Shared Neighborhood Hits	37
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

DBNL_HUMAN
NC score	0.066532 (rank : 283)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	177	Target Neighborhood Hits	244	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PACN3_MOUSE
NC score	0.066410 (rank : 284)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	177	Target Neighborhood Hits	380	Shared Neighborhood Hits	43
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

YLPM1_MOUSE
NC score	0.066123 (rank : 285)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	177	Target Neighborhood Hits	505	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

CPSF6_HUMAN
NC score	0.066090 (rank : 286)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	177	Target Neighborhood Hits	359	Shared Neighborhood Hits	31
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

NCOA6_MOUSE
NC score	0.065766 (rank : 287)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	177	Target Neighborhood Hits	1076	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

DDR1_MOUSE
NC score	0.065577 (rank : 288)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	177	Target Neighborhood Hits	818	Shared Neighborhood Hits	35
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.065510 (rank : 289)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	177	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

ANM2_HUMAN
NC score	0.065465 (rank : 290)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	37
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

TNK1_HUMAN
NC score	0.065427 (rank : 291)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	177	Target Neighborhood Hits	815	Shared Neighborhood Hits	40
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

FAK2_HUMAN
NC score	0.065395 (rank : 292)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	177	Target Neighborhood Hits	847	Shared Neighborhood Hits	34
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LASP1_MOUSE
NC score	0.065384 (rank : 293)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	37
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SRRM2_HUMAN
NC score	0.065373 (rank : 294)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	177	Target Neighborhood Hits	1296	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

DNMBP_MOUSE
NC score	0.065241 (rank : 295)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FAK2_MOUSE
NC score	0.065067 (rank : 296)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	177	Target Neighborhood Hits	851	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EPHAA_HUMAN
NC score	0.064898 (rank : 297)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	177	Target Neighborhood Hits	960	Shared Neighborhood Hits	35
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ERBB2_HUMAN
NC score	0.064762 (rank : 298)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	177	Target Neighborhood Hits	1073	Shared Neighborhood Hits	44
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ES8L1_HUMAN
NC score	0.064748 (rank : 299)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	177	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MLL3_MOUSE
NC score	0.064583 (rank : 300)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	1399	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

ERBB2_MOUSE
NC score	0.064238 (rank : 301)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	177	Target Neighborhood Hits	918	Shared Neighborhood Hits	39
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

TNK1_MOUSE
NC score	0.064100 (rank : 302)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	177	Target Neighborhood Hits	806	Shared Neighborhood Hits	39
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

ARI1B_HUMAN
NC score	0.064075 (rank : 303)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	177	Target Neighborhood Hits	567	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

NTRK1_HUMAN
NC score	0.064019 (rank : 304)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	177	Target Neighborhood Hits	1023	Shared Neighborhood Hits	33
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

ERBB3_HUMAN
NC score	0.063923 (rank : 305)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	177	Target Neighborhood Hits	918	Shared Neighborhood Hits	32
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

SFPQ_HUMAN
NC score	0.063918 (rank : 306)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	177	Target Neighborhood Hits	986	Shared Neighborhood Hits	47
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

EPHB6_HUMAN
NC score	0.063729 (rank : 307)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	177	Target Neighborhood Hits	912	Shared Neighborhood Hits	36
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

MLL3_HUMAN
NC score	0.063713 (rank : 308)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	1644	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ERBB3_MOUSE
NC score	0.063649 (rank : 309)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	177	Target Neighborhood Hits	898	Shared Neighborhood Hits	33
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

LAD1_HUMAN
NC score	0.063640 (rank : 310)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	177	Target Neighborhood Hits	441	Shared Neighborhood Hits	28
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

FLT3_MOUSE
NC score	0.063605 (rank : 311)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	177	Target Neighborhood Hits	847	Shared Neighborhood Hits	33
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

EPHB6_MOUSE
NC score	0.063546 (rank : 312)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	177	Target Neighborhood Hits	906	Shared Neighborhood Hits	36
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHA6_HUMAN
NC score	0.063540 (rank : 313)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	177	Target Neighborhood Hits	959	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

WASF1_HUMAN
NC score	0.063354 (rank : 314)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	177	Target Neighborhood Hits	260	Shared Neighborhood Hits	27
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

FLT3_HUMAN
NC score	0.063340 (rank : 315)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	177	Target Neighborhood Hits	843	Shared Neighborhood Hits	33
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

ERBB4_HUMAN
NC score	0.063328 (rank : 316)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	177	Target Neighborhood Hits	910	Shared Neighborhood Hits	34
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

IGF1R_MOUSE
NC score	0.063320 (rank : 317)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	177	Target Neighborhood Hits	973	Shared Neighborhood Hits	33
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

EPHA6_MOUSE
NC score	0.063312 (rank : 318)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	177	Target Neighborhood Hits	946	Shared Neighborhood Hits	36
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

IGF1R_HUMAN
NC score	0.063196 (rank : 319)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	177	Target Neighborhood Hits	977	Shared Neighborhood Hits	33
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

NEBL_HUMAN
NC score	0.063167 (rank : 320)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	177	Target Neighborhood Hits	457	Shared Neighborhood Hits	42
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

INSRR_HUMAN
NC score	0.063131 (rank : 321)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	177	Target Neighborhood Hits	950	Shared Neighborhood Hits	35
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

CSF1R_HUMAN
NC score	0.063113 (rank : 322)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	177	Target Neighborhood Hits	943	Shared Neighborhood Hits	33
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

M3KL4_HUMAN
NC score	0.063025 (rank : 323)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	177	Target Neighborhood Hits	1087	Shared Neighborhood Hits	53
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

INSRR_MOUSE
NC score	0.062956 (rank : 324)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	177	Target Neighborhood Hits	961	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

WASF2_MOUSE
NC score	0.062937 (rank : 325)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	177	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

EPHA5_MOUSE
NC score	0.062922 (rank : 326)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	177	Target Neighborhood Hits	950	Shared Neighborhood Hits	37
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

MERTK_HUMAN
NC score	0.062855 (rank : 327)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	177	Target Neighborhood Hits	988	Shared Neighborhood Hits	35
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FAK1_MOUSE
NC score	0.062847 (rank : 328)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	177	Target Neighborhood Hits	850	Shared Neighborhood Hits	34
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.062811 (rank : 329)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	177	Target Neighborhood Hits	850	Shared Neighborhood Hits	33
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

NTRK3_HUMAN
NC score	0.062797 (rank : 330)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	177	Target Neighborhood Hits	1115	Shared Neighborhood Hits	33
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

ASPP1_HUMAN
NC score	0.062684 (rank : 331)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	177	Target Neighborhood Hits	956	Shared Neighborhood Hits	54
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

TEX14_HUMAN
NC score	0.062659 (rank : 332)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	177	Target Neighborhood Hits	1103	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ROR2_MOUSE
NC score	0.062604 (rank : 333)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	177	Target Neighborhood Hits	1000	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

DDR2_HUMAN
NC score	0.062345 (rank : 334)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	177	Target Neighborhood Hits	818	Shared Neighborhood Hits	33
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

WASF1_MOUSE
NC score	0.062340 (rank : 335)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	177	Target Neighborhood Hits	261	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

PGFRB_HUMAN
NC score	0.062278 (rank : 336)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	177	Target Neighborhood Hits	962	Shared Neighborhood Hits	33
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

DDR2_MOUSE
NC score	0.062269 (rank : 337)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	177	Target Neighborhood Hits	813	Shared Neighborhood Hits	33
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

MERTK_MOUSE
NC score	0.062194 (rank : 338)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	177	Target Neighborhood Hits	974	Shared Neighborhood Hits	33
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MDC1_MOUSE
NC score	0.062172 (rank : 339)	θ value	0.0961366 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	998	Shared Neighborhood Hits	49
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PGFRB_MOUSE
NC score	0.062114 (rank : 340)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	177	Target Neighborhood Hits	960	Shared Neighborhood Hits	33
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

BCAR1_MOUSE
NC score	0.062103 (rank : 341)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	177	Target Neighborhood Hits	438	Shared Neighborhood Hits	55
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EPHA1_MOUSE
NC score	0.062087 (rank : 342)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	38
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

RON_MOUSE
NC score	0.062074 (rank : 343)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	177	Target Neighborhood Hits	836	Shared Neighborhood Hits	32
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

INSR_HUMAN
NC score	0.061966 (rank : 344)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	177	Target Neighborhood Hits	963	Shared Neighborhood Hits	33
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

PGFRA_MOUSE
NC score	0.061766 (rank : 345)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	177	Target Neighborhood Hits	975	Shared Neighborhood Hits	33
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

EPHA1_HUMAN
NC score	0.061755 (rank : 346)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	177	Target Neighborhood Hits	997	Shared Neighborhood Hits	35
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

INSR_MOUSE
NC score	0.061727 (rank : 347)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	177	Target Neighborhood Hits	968	Shared Neighborhood Hits	34
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHA2_MOUSE
NC score	0.061707 (rank : 348)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	177	Target Neighborhood Hits	1020	Shared Neighborhood Hits	38
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EGFR_HUMAN
NC score	0.061574 (rank : 349)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	177	Target Neighborhood Hits	939	Shared Neighborhood Hits	33
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

PGFRA_HUMAN
NC score	0.061556 (rank : 350)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	177	Target Neighborhood Hits	980	Shared Neighborhood Hits	33
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

M3K9_HUMAN
NC score	0.061550 (rank : 351)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	177	Target Neighborhood Hits	1123	Shared Neighborhood Hits	62
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

EGFR_MOUSE
NC score	0.061547 (rank : 352)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	177	Target Neighborhood Hits	927	Shared Neighborhood Hits	33
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA2_HUMAN
NC score	0.061463 (rank : 353)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	177	Target Neighborhood Hits	1021	Shared Neighborhood Hits	38
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

TYK2_MOUSE
NC score	0.061311 (rank : 354)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UFO_HUMAN
NC score	0.061281 (rank : 355)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	177	Target Neighborhood Hits	981	Shared Neighborhood Hits	34
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

M3K10_HUMAN
NC score	0.061280 (rank : 356)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	177	Target Neighborhood Hits	1071	Shared Neighborhood Hits	56
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

CSF1R_MOUSE
NC score	0.061223 (rank : 357)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	177	Target Neighborhood Hits	983	Shared Neighborhood Hits	33
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ES8L2_HUMAN
NC score	0.061223 (rank : 358)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	177	Target Neighborhood Hits	193	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

PRRT3_HUMAN
NC score	0.061207 (rank : 359)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	998	Shared Neighborhood Hits	44
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

EPHB3_MOUSE
NC score	0.061086 (rank : 360)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	177	Target Neighborhood Hits	996	Shared Neighborhood Hits	37
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

RON_HUMAN
NC score	0.061076 (rank : 361)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	177	Target Neighborhood Hits	842	Shared Neighborhood Hits	32
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

MISS_MOUSE
NC score	0.061072 (rank : 362)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	177	Target Neighborhood Hits	444	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

EPHB3_HUMAN
NC score	0.061020 (rank : 363)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	177	Target Neighborhood Hits	996	Shared Neighborhood Hits	37
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB4_HUMAN
NC score	0.061013 (rank : 364)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	177	Target Neighborhood Hits	1056	Shared Neighborhood Hits	37
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ROR2_HUMAN
NC score	0.060997 (rank : 365)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	177	Target Neighborhood Hits	1014	Shared Neighborhood Hits	33
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

RET_HUMAN
NC score	0.060981 (rank : 366)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	177	Target Neighborhood Hits	873	Shared Neighborhood Hits	33
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MET_MOUSE
NC score	0.060897 (rank : 367)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	177	Target Neighborhood Hits	844	Shared Neighborhood Hits	32
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA8_HUMAN
NC score	0.060770 (rank : 368)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	177	Target Neighborhood Hits	956	Shared Neighborhood Hits	37
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

KIT_MOUSE
NC score	0.060754 (rank : 369)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	177	Target Neighborhood Hits	949	Shared Neighborhood Hits	33
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

UFO_MOUSE
NC score	0.060739 (rank : 370)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	177	Target Neighborhood Hits	988	Shared Neighborhood Hits	33
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

EPHA8_MOUSE
NC score	0.060737 (rank : 371)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	177	Target Neighborhood Hits	969	Shared Neighborhood Hits	37
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

JAK1_MOUSE
NC score	0.060734 (rank : 372)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	177	Target Neighborhood Hits	854	Shared Neighborhood Hits	37
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

EPHA5_HUMAN
NC score	0.060703 (rank : 373)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	38
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB2_MOUSE
NC score	0.060678 (rank : 374)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	177	Target Neighborhood Hits	982	Shared Neighborhood Hits	37
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB4_MOUSE
NC score	0.060668 (rank : 375)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	177	Target Neighborhood Hits	1013	Shared Neighborhood Hits	37
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA4_MOUSE
NC score	0.060653 (rank : 376)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	177	Target Neighborhood Hits	982	Shared Neighborhood Hits	35
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHB2_HUMAN
NC score	0.060650 (rank : 377)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	177	Target Neighborhood Hits	983	Shared Neighborhood Hits	37
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA4_HUMAN
NC score	0.060644 (rank : 378)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	177	Target Neighborhood Hits	975	Shared Neighborhood Hits	35
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

ES8L2_MOUSE
NC score	0.060623 (rank : 379)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	177	Target Neighborhood Hits	169	Shared Neighborhood Hits	35
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MET_HUMAN
NC score	0.060579 (rank : 380)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	177	Target Neighborhood Hits	831	Shared Neighborhood Hits	33
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RET_MOUSE
NC score	0.060450 (rank : 381)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	177	Target Neighborhood Hits	884	Shared Neighborhood Hits	33
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

KIT_HUMAN
NC score	0.060371 (rank : 382)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	177	Target Neighborhood Hits	953	Shared Neighborhood Hits	33
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

ROR1_MOUSE
NC score	0.060294 (rank : 383)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	177	Target Neighborhood Hits	1025	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ANM2_MOUSE
NC score	0.060274 (rank : 384)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	177	Target Neighborhood Hits	175	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

EP300_HUMAN
NC score	0.060132 (rank : 385)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	821	Shared Neighborhood Hits	43
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

TYRO3_MOUSE
NC score	0.060121 (rank : 386)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	177	Target Neighborhood Hits	1007	Shared Neighborhood Hits	33
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

NTRK2_HUMAN
NC score	0.060100 (rank : 387)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	177	Target Neighborhood Hits	1081	Shared Neighborhood Hits	33
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

JAK1_HUMAN
NC score	0.060088 (rank : 388)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	177	Target Neighborhood Hits	858	Shared Neighborhood Hits	37
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

NTRK2_MOUSE
NC score	0.060054 (rank : 389)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	177	Target Neighborhood Hits	1088	Shared Neighborhood Hits	33
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ROR1_HUMAN
NC score	0.059992 (rank : 390)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	177	Target Neighborhood Hits	1018	Shared Neighborhood Hits	33
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TYRO3_HUMAN
NC score	0.059961 (rank : 391)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	177	Target Neighborhood Hits	995	Shared Neighborhood Hits	33
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHB1_HUMAN
NC score	0.059865 (rank : 392)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	177	Target Neighborhood Hits	988	Shared Neighborhood Hits	37
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

FGFR4_MOUSE
NC score	0.059637 (rank : 393)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	177	Target Neighborhood Hits	1026	Shared Neighborhood Hits	33
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA7_HUMAN
NC score	0.059503 (rank : 394)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	177	Target Neighborhood Hits	1053	Shared Neighborhood Hits	37
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

AUTS2_HUMAN
NC score	0.059440 (rank : 395)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	177	Target Neighborhood Hits	342	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

EPHA7_MOUSE
NC score	0.059432 (rank : 396)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	177	Target Neighborhood Hits	1025	Shared Neighborhood Hits	37
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

ASPP2_HUMAN
NC score	0.059429 (rank : 397)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	1156	Shared Neighborhood Hits	57
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

EPHA3_MOUSE
NC score	0.059397 (rank : 398)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	177	Target Neighborhood Hits	1009	Shared Neighborhood Hits	33
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA3_HUMAN
NC score	0.059378 (rank : 399)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	177	Target Neighborhood Hits	1005	Shared Neighborhood Hits	33
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

BASP_MOUSE
NC score	0.059280 (rank : 400)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	177	Target Neighborhood Hits	260	Shared Neighborhood Hits	20
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

SF3A2_MOUSE
NC score	0.059018 (rank : 401)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	177	Target Neighborhood Hits	247	Shared Neighborhood Hits	27
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

WBS14_HUMAN
NC score	0.058939 (rank : 402)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	177	Target Neighborhood Hits	273	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

MUC7_HUMAN
NC score	0.058840 (rank : 403)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	177	Target Neighborhood Hits	538	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

RERE_MOUSE
NC score	0.058723 (rank : 404)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	177	Target Neighborhood Hits	785	Shared Neighborhood Hits	46
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

WASF4_HUMAN
NC score	0.058547 (rank : 405)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	177	Target Neighborhood Hits	282	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

SGIP1_HUMAN
NC score	0.058506 (rank : 406)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	177	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

CHIO_HUMAN
NC score	0.058414 (rank : 407)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	177	Target Neighborhood Hits	220	Shared Neighborhood Hits	49
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

MUSK_MOUSE
NC score	0.058365 (rank : 408)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	177	Target Neighborhood Hits	1057	Shared Neighborhood Hits	33
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

FGFR4_HUMAN
NC score	0.058317 (rank : 409)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	177	Target Neighborhood Hits	1037	Shared Neighborhood Hits	33
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

MUSK_HUMAN
NC score	0.058195 (rank : 410)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	177	Target Neighborhood Hits	1074	Shared Neighborhood Hits	33
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

ES8L1_MOUSE
NC score	0.058082 (rank : 411)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	177	Target Neighborhood Hits	143	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

GSCR1_HUMAN
NC score	0.058005 (rank : 412)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	177	Target Neighborhood Hits	674	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

SH3G3_MOUSE
NC score	0.057438 (rank : 413)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	177	Target Neighborhood Hits	236	Shared Neighborhood Hits	37
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

BASP_HUMAN
NC score	0.057195 (rank : 414)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	177	Target Neighborhood Hits	321	Shared Neighborhood Hits	27
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

SON_HUMAN
NC score	0.057184 (rank : 415)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	1568	Shared Neighborhood Hits	67
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

JAK3_HUMAN
NC score	0.057154 (rank : 416)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	177	Target Neighborhood Hits	827	Shared Neighborhood Hits	33
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

TYK2_HUMAN
NC score	0.057131 (rank : 417)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	177	Target Neighborhood Hits	841	Shared Neighborhood Hits	33
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

GUC2F_HUMAN
NC score	0.056872 (rank : 418)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	177	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

TCOF_MOUSE
NC score	0.056868 (rank : 419)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	177	Target Neighborhood Hits	471	Shared Neighborhood Hits	30
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TIE2_HUMAN
NC score	0.056815 (rank : 420)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	177	Target Neighborhood Hits	1192	Shared Neighborhood Hits	34
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE1_HUMAN
NC score	0.056802 (rank : 421)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	177	Target Neighborhood Hits	1241	Shared Neighborhood Hits	34
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_MOUSE
NC score	0.056752 (rank : 422)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	177	Target Neighborhood Hits	1204	Shared Neighborhood Hits	34
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TEX14_MOUSE
NC score	0.056744 (rank : 423)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	177	Target Neighborhood Hits	1333	Shared Neighborhood Hits	42
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

VGFR3_MOUSE
NC score	0.056739 (rank : 424)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	177	Target Neighborhood Hits	1056	Shared Neighborhood Hits	33
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

TIE1_MOUSE
NC score	0.056663 (rank : 425)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	177	Target Neighborhood Hits	1266	Shared Neighborhood Hits	34
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

FGFR3_HUMAN
NC score	0.056633 (rank : 426)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	177	Target Neighborhood Hits	1042	Shared Neighborhood Hits	33
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

PTK7_HUMAN
NC score	0.056614 (rank : 427)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	177	Target Neighborhood Hits	1103	Shared Neighborhood Hits	32
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

FGFR2_MOUSE
NC score	0.056533 (rank : 428)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	177	Target Neighborhood Hits	1062	Shared Neighborhood Hits	33
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

PEX13_HUMAN
NC score	0.056527 (rank : 429)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	177	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

FGFR3_MOUSE
NC score	0.056319 (rank : 430)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	177	Target Neighborhood Hits	1059	Shared Neighborhood Hits	33
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR2_HUMAN
NC score	0.056287 (rank : 431)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	177	Target Neighborhood Hits	1062	Shared Neighborhood Hits	33
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

RERE_HUMAN
NC score	0.056262 (rank : 432)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	177	Target Neighborhood Hits	779	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

NSD1_MOUSE
NC score	0.056091 (rank : 433)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	177	Target Neighborhood Hits	472	Shared Neighborhood Hits	29
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

VGFR3_HUMAN
NC score	0.056063 (rank : 434)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	177	Target Neighborhood Hits	1037	Shared Neighborhood Hits	33
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_MOUSE
NC score	0.056063 (rank : 435)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	177	Target Neighborhood Hits	1068	Shared Neighborhood Hits	34
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.056003 (rank : 436)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	177	Target Neighborhood Hits	1069	Shared Neighborhood Hits	34
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

SH3G2_HUMAN
NC score	0.055992 (rank : 437)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	39
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PRR8_HUMAN
NC score	0.055970 (rank : 438)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RNC_HUMAN
NC score	0.055834 (rank : 439)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	177	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

JAK2_MOUSE
NC score	0.055693 (rank : 440)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	177	Target Neighborhood Hits	839	Shared Neighborhood Hits	34
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_HUMAN
NC score	0.055366 (rank : 441)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	177	Target Neighborhood Hits	847	Shared Neighborhood Hits	34
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

VGFR2_HUMAN
NC score	0.055350 (rank : 442)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	177	Target Neighborhood Hits	1103	Shared Neighborhood Hits	35
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

K1543_MOUSE
NC score	0.055206 (rank : 443)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	497	Shared Neighborhood Hits	32
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

ILK_MOUSE
NC score	0.055149 (rank : 444)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	177	Target Neighborhood Hits	858	Shared Neighborhood Hits	34
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

SMR1_MOUSE
NC score	0.055144 (rank : 445)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	177	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

SH3G2_MOUSE
NC score	0.055124 (rank : 446)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	177	Target Neighborhood Hits	319	Shared Neighborhood Hits	38
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

VGFR2_MOUSE
NC score	0.055039 (rank : 447)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	177	Target Neighborhood Hits	1089	Shared Neighborhood Hits	33
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

BRD4_MOUSE
NC score	0.054961 (rank : 448)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	177	Target Neighborhood Hits	845	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

JAK3_MOUSE
NC score	0.054879 (rank : 449)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	177	Target Neighborhood Hits	821	Shared Neighborhood Hits	33
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

GUC2C_HUMAN
NC score	0.054836 (rank : 450)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	177	Target Neighborhood Hits	624	Shared Neighborhood Hits	32
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ILK1_HUMAN
NC score	0.054663 (rank : 451)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	177	Target Neighborhood Hits	857	Shared Neighborhood Hits	33
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

RUSC1_HUMAN
NC score	0.054595 (rank : 452)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	177	Target Neighborhood Hits	226	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

WASF2_HUMAN
NC score	0.054479 (rank : 453)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	177	Target Neighborhood Hits	280	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

SASH1_HUMAN
NC score	0.054471 (rank : 454)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	292	Shared Neighborhood Hits	30
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

CIP4_HUMAN
NC score	0.054410 (rank : 455)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	177	Target Neighborhood Hits	374	Shared Neighborhood Hits	34
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

VGFR1_HUMAN
NC score	0.054395 (rank : 456)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	177	Target Neighborhood Hits	1109	Shared Neighborhood Hits	33
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ANPRA_HUMAN
NC score	0.054267 (rank : 457)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	177	Target Neighborhood Hits	612	Shared Neighborhood Hits	31
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

PTN23_MOUSE
NC score	0.054257 (rank : 458)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	177	Target Neighborhood Hits	726	Shared Neighborhood Hits	38
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SRRM2_MOUSE
NC score	0.054186 (rank : 459)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	177	Target Neighborhood Hits	1470	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ANPRA_MOUSE
NC score	0.054077 (rank : 460)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	177	Target Neighborhood Hits	600	Shared Neighborhood Hits	31
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ILK2_HUMAN
NC score	0.054008 (rank : 461)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	177	Target Neighborhood Hits	848	Shared Neighborhood Hits	33
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

VGFR1_MOUSE
NC score	0.053974 (rank : 462)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	177	Target Neighborhood Hits	1118	Shared Neighborhood Hits	33
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

GON4L_HUMAN
NC score	0.053907 (rank : 463)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	555	Shared Neighborhood Hits	28
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

FMN1A_MOUSE
NC score	0.053641 (rank : 464)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	177	Target Neighborhood Hits	423	Shared Neighborhood Hits	33
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

SH3G1_MOUSE
NC score	0.053636 (rank : 465)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	177	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ARAF_MOUSE
NC score	0.053087 (rank : 466)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	177	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

RAF1_HUMAN
NC score	0.053013 (rank : 467)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	177	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

SMR3A_HUMAN
NC score	0.052948 (rank : 468)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

MLTK_MOUSE
NC score	0.052873 (rank : 469)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	177	Target Neighborhood Hits	874	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

PCQAP_HUMAN
NC score	0.052856 (rank : 470)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	177	Target Neighborhood Hits	549	Shared Neighborhood Hits	27
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

ARAF_HUMAN
NC score	0.052837 (rank : 471)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	177	Target Neighborhood Hits	924	Shared Neighborhood Hits	38
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PRCC_HUMAN
NC score	0.052835 (rank : 472)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

AFF1_HUMAN
NC score	0.052832 (rank : 473)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	506	Shared Neighborhood Hits	40
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

BRAF1_HUMAN
NC score	0.052818 (rank : 474)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	177	Target Neighborhood Hits	883	Shared Neighborhood Hits	35
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

SASH1_MOUSE
NC score	0.052797 (rank : 475)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	263	Shared Neighborhood Hits	30
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

MLTK_HUMAN
NC score	0.052787 (rank : 476)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	177	Target Neighborhood Hits	911	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

FMN1B_MOUSE
NC score	0.052745 (rank : 477)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	33
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

PHAR2_HUMAN
NC score	0.052742 (rank : 478)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	177	Target Neighborhood Hits	208	Shared Neighborhood Hits	22
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

RAF1_MOUSE
NC score	0.052736 (rank : 479)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	177	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CT032_HUMAN
NC score	0.052548 (rank : 480)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	177	Target Neighborhood Hits	235	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

KSR2_HUMAN
NC score	0.052448 (rank : 481)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	177	Target Neighborhood Hits	920	Shared Neighborhood Hits	45
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

ATX7_HUMAN
NC score	0.052417 (rank : 482)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	351	Shared Neighborhood Hits	27
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

YYAP1_HUMAN
NC score	0.052397 (rank : 483)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H869, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84	Gene names	YY1AP1, HCCA2, YY1AP
Domain Architecture	No domain graphic available
Description	YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2).

PLCB3_MOUSE
NC score	0.052366 (rank : 484)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	177	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

RIPK1_MOUSE
NC score	0.052131 (rank : 485)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	177	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ECM1_HUMAN
NC score	0.052101 (rank : 486)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	177	Target Neighborhood Hits	182	Shared Neighborhood Hits	17
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

NOLC1_HUMAN
NC score	0.051992 (rank : 487)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	177	Target Neighborhood Hits	452	Shared Neighborhood Hits	32
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

SH3G1_HUMAN
NC score	0.051972 (rank : 488)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

MLKL_HUMAN
NC score	0.051958 (rank : 489)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	177	Target Neighborhood Hits	600	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

IRAK3_MOUSE
NC score	0.051936 (rank : 490)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	177	Target Neighborhood Hits	628	Shared Neighborhood Hits	33
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

PAIRB_HUMAN
NC score	0.051764 (rank : 491)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NC51, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3	Gene names	SERBP1, PAIRBP1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

MLKL_MOUSE
NC score	0.051723 (rank : 492)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	177	Target Neighborhood Hits	707	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

KSR1_HUMAN
NC score	0.051653 (rank : 493)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	177	Target Neighborhood Hits	867	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ANPRB_MOUSE
NC score	0.051563 (rank : 494)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	177	Target Neighborhood Hits	607	Shared Neighborhood Hits	35
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

FA47B_HUMAN
NC score	0.051345 (rank : 495)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	431	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GUC2E_MOUSE
NC score	0.051291 (rank : 496)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	177	Target Neighborhood Hits	692	Shared Neighborhood Hits	31
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

PLCB3_HUMAN
NC score	0.051279 (rank : 497)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	177	Target Neighborhood Hits	445	Shared Neighborhood Hits	11
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PTN23_HUMAN
NC score	0.051265 (rank : 498)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	177	Target Neighborhood Hits	646	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

ANPRB_HUMAN
NC score	0.051180 (rank : 499)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	177	Target Neighborhood Hits	646	Shared Neighborhood Hits	35
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

NOXO1_MOUSE
NC score	0.051147 (rank : 500)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	177	Target Neighborhood Hits	114	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

MOS_HUMAN
NC score	0.051088 (rank : 501)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	177	Target Neighborhood Hits	829	Shared Neighborhood Hits	33
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

CS016_HUMAN
NC score	0.051074 (rank : 502)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	177	Target Neighborhood Hits	310	Shared Neighborhood Hits	34
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

KSR1_MOUSE
NC score	0.051038 (rank : 503)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	177	Target Neighborhood Hits	870	Shared Neighborhood Hits	33
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

RIPK1_HUMAN
NC score	0.050993 (rank : 504)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	177	Target Neighborhood Hits	891	Shared Neighborhood Hits	35
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

GUC2D_HUMAN
NC score	0.050918 (rank : 505)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	177	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

MUC2_HUMAN
NC score	0.050905 (rank : 506)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	177	Target Neighborhood Hits	906	Shared Neighborhood Hits	43
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MOS_MOUSE
NC score	0.050823 (rank : 507)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	177	Target Neighborhood Hits	833	Shared Neighborhood Hits	33
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

RIPK2_MOUSE
NC score	0.050818 (rank : 508)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	177	Target Neighborhood Hits	776	Shared Neighborhood Hits	33
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK2_HUMAN
NC score	0.050612 (rank : 509)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	177	Target Neighborhood Hits	774	Shared Neighborhood Hits	32
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

M3K12_HUMAN
NC score	0.050599 (rank : 510)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	177	Target Neighborhood Hits	940	Shared Neighborhood Hits	44
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

RIPK3_MOUSE
NC score	0.050595 (rank : 511)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	177	Target Neighborhood Hits	867	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RHG04_HUMAN
NC score	0.050512 (rank : 512)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_HUMAN
NC score	0.050205 (rank : 513)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	177	Target Neighborhood Hits	331	Shared Neighborhood Hits	44
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

NACAM_MOUSE
NC score	0.050054 (rank : 514)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	177	Target Neighborhood Hits	1866	Shared Neighborhood Hits	71
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ALEX_MOUSE
NC score	0.050031 (rank : 515)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	20
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

M3K12_MOUSE
NC score	0.050002 (rank : 516)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	177	Target Neighborhood Hits	957	Shared Neighborhood Hits	42
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

MAGE1_HUMAN
NC score	0.049919 (rank : 517)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	1389	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PYR1_HUMAN
NC score	0.049573 (rank : 518)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	119	Shared Neighborhood Hits	7
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

SHAN2_HUMAN
NC score	0.049199 (rank : 519)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	346	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SPEG_MOUSE
NC score	0.047582 (rank : 520)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	1959	Shared Neighborhood Hits	83
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

K1267_HUMAN
NC score	0.046757 (rank : 521)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z3B3, Q6AW85, Q8IYH1, Q9NTE7, Q9UFT0, Q9ULF3	Gene names	KIAA1267
Domain Architecture	No domain graphic available
Description	Protein KIAA1267.

BSN_MOUSE
NC score	0.044914 (rank : 522)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	2057	Shared Neighborhood Hits	70
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

TM108_MOUSE
NC score	0.042737 (rank : 523)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	336	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

ANK2_HUMAN
NC score	0.040376 (rank : 524)	θ value	0.0330416 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	1615	Shared Neighborhood Hits	53
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

SETD2_HUMAN
NC score	0.040026 (rank : 525)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	412	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

QSCN6_HUMAN
NC score	0.039634 (rank : 526)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

TACC1_MOUSE
NC score	0.039288 (rank : 527)	θ value	0.0961366 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	667	Shared Neighborhood Hits	20
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TITIN_HUMAN
NC score	0.038887 (rank : 528)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	2923	Shared Neighborhood Hits	80
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CS007_MOUSE
NC score	0.037819 (rank : 529)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	464	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

ELOA3_HUMAN
NC score	0.037589 (rank : 530)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

K1267_MOUSE
NC score	0.037162 (rank : 531)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TG1, Q3TT88, Q3U5D8, Q3V3N3, Q7TMU3, Q80XP7, Q8R3L6, Q9D9G0	Gene names	Kiaa1267
Domain Architecture	No domain graphic available
Description	Protein KIAA1267.

ZO1_HUMAN
NC score	0.036232 (rank : 532)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	474	Shared Neighborhood Hits	24
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PAIRB_MOUSE
NC score	0.036064 (rank : 533)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CY58, Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9DBY6	Gene names	Serbp1, Pairbp1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

LEO1_MOUSE
NC score	0.034173 (rank : 534)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	946	Shared Neighborhood Hits	20
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

ZC313_HUMAN
NC score	0.034025 (rank : 535)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	772	Shared Neighborhood Hits	18
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

JPH2_HUMAN
NC score	0.033970 (rank : 536)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	639	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

UBP2L_HUMAN
NC score	0.033200 (rank : 537)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

MAST4_HUMAN
NC score	0.032861 (rank : 538)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	1804	Shared Neighborhood Hits	78
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

CTRO_HUMAN
NC score	0.032460 (rank : 539)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	2092	Shared Neighborhood Hits	60
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CECR2_HUMAN
NC score	0.031945 (rank : 540)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

NFAC1_HUMAN
NC score	0.030659 (rank : 541)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	312	Shared Neighborhood Hits	27
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

CTRO_MOUSE
NC score	0.030157 (rank : 542)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	2344	Shared Neighborhood Hits	61
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

THAP3_HUMAN
NC score	0.029340 (rank : 543)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WTV1, Q569K1, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3	Gene names	THAP3
Domain Architecture
Description	THAP domain-containing protein 3.

PHLB1_HUMAN
NC score	0.028596 (rank : 544)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	1038	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

NRX2B_HUMAN
NC score	0.027374 (rank : 545)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	481	Shared Neighborhood Hits	21
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PHAR3_MOUSE
NC score	0.027305 (rank : 546)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BYK5, Q8BYS8, Q8C058, Q9DB87	Gene names	Phactr3, Scapin1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

LEO1_HUMAN
NC score	0.026488 (rank : 547)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	958	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

K1688_HUMAN
NC score	0.025032 (rank : 548)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	217	Shared Neighborhood Hits	17
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

CLCN1_HUMAN
NC score	0.023553 (rank : 549)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	8
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

AHR_MOUSE
NC score	0.021865 (rank : 550)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CXXC6_HUMAN
NC score	0.020747 (rank : 551)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NFU7, Q5VUP7, Q7Z6B6, Q8TCR1, Q9C0I7	Gene names	CXXC6, KIAA1676, LCX
Domain Architecture	No domain graphic available
Description	CXXC-type zinc finger protein 6 (Leukemia-associated protein with a CXXC domain).

CEP72_HUMAN
NC score	0.020707 (rank : 552)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	374	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

SOS1_HUMAN
NC score	0.019390 (rank : 553)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

DSPP_HUMAN
NC score	0.019074 (rank : 554)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	645	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

NRX2A_HUMAN
NC score	0.018313 (rank : 555)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	614	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

TMM91_MOUSE
NC score	0.015673 (rank : 556)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C581	Gene names	Tmem91
Domain Architecture	No domain graphic available
Description	Transmembrane protein 91.

ZEP1_MOUSE
NC score	0.014663 (rank : 557)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	1063	Shared Neighborhood Hits	26
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

SIX5_MOUSE
NC score	0.013799 (rank : 558)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	354	Shared Neighborhood Hits	15
SwissProt Accessions	P70178	Gene names	Six5, Dmahp
Domain Architecture
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein homolog).

ANKS6_MOUSE
NC score	0.013178 (rank : 559)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	435	Shared Neighborhood Hits	17
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ZN516_MOUSE
NC score	0.012026 (rank : 560)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	1197	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZHX2_HUMAN
NC score	0.011783 (rank : 561)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	347	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

BICD1_MOUSE
NC score	0.011462 (rank : 562)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	837	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

FRMD6_MOUSE
NC score	0.010985 (rank : 563)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

ATAD2_MOUSE
NC score	0.010324 (rank : 564)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	167	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

FLIP1_MOUSE
NC score	0.009528 (rank : 565)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	1176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CYTSA_HUMAN
NC score	0.009476 (rank : 566)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	1138	Shared Neighborhood Hits	24
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

TCAL5_HUMAN
NC score	0.008671 (rank : 567)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	806	Shared Neighborhood Hits	18
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

CO8A_HUMAN
NC score	0.008040 (rank : 568)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	200	Shared Neighborhood Hits	3
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

XKR7_HUMAN
NC score	0.007758 (rank : 569)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q5GH72, Q9NUG5	Gene names	XKR7, C20orf159, XRG7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

RCN3_HUMAN
NC score	0.007019 (rank : 570)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q96D15, Q9HBZ8	Gene names	RCN3
Domain Architecture
Description	Reticulocalbin-3 precursor (EF-hand calcium-binding protein RLP49).

LIMD1_HUMAN
NC score	0.006101 (rank : 571)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

ZN580_HUMAN
NC score	0.000852 (rank : 572)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	727	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UK33, Q9NPP7	Gene names	ZNF580
Domain Architecture	No domain graphic available
Description	Zinc finger protein 580 (LDL-induced EC protein).

ZN688_HUMAN
NC score	-0.002933 (rank : 573)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	873	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.