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Network neighborhood for query Sequence : LASP1_HUMAN

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LASP1_HUMAN
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LASP1_MOUSE
θ value	7.8238e-137 (rank : 1)	NC score	0.996858 (rank : 2)
Query Neighborhood Hits	293	Target Neighborhood Hits	297	Shared Neighborhood Hits	285
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_HUMAN
θ value	7.59556e-124 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	293
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NEBL_HUMAN
θ value	3.28125e-26 (rank : 3)	NC score	0.644977 (rank : 3)
Query Neighborhood Hits	293	Target Neighborhood Hits	457	Shared Neighborhood Hits	171
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NRAP_HUMAN
θ value	9.87957e-23 (rank : 4)	NC score	0.554280 (rank : 9)
Query Neighborhood Hits	293	Target Neighborhood Hits	159	Shared Neighborhood Hits	105
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	9.87957e-23 (rank : 5)	NC score	0.554213 (rank : 10)
Query Neighborhood Hits	293	Target Neighborhood Hits	167	Shared Neighborhood Hits	101
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NEBU_HUMAN
θ value	2.87452e-22 (rank : 6)	NC score	0.633578 (rank : 4)
Query Neighborhood Hits	293	Target Neighborhood Hits	420	Shared Neighborhood Hits	160
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SRC8_MOUSE
θ value	2.52405e-10 (rank : 7)	NC score	0.567835 (rank : 7)
Query Neighborhood Hits	293	Target Neighborhood Hits	292	Shared Neighborhood Hits	152
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
θ value	5.62301e-10 (rank : 8)	NC score	0.569376 (rank : 6)
Query Neighborhood Hits	293	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DBNL_HUMAN
θ value	4.76016e-09 (rank : 9)	NC score	0.521081 (rank : 20)
Query Neighborhood Hits	293	Target Neighborhood Hits	244	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

CRIP1_HUMAN
θ value	1.38499e-08 (rank : 10)	NC score	0.526128 (rank : 18)
Query Neighborhood Hits	293	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P50238, Q13628, Q96J34	Gene names	CRIP1, CRIP
Domain Architecture
Description	Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP) (Cysteine-rich heart protein) (hCRHP).

VINEX_HUMAN
θ value	1.38499e-08 (rank : 11)	NC score	0.569562 (rank : 5)
Query Neighborhood Hits	293	Target Neighborhood Hits	270	Shared Neighborhood Hits	167
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

CRIP1_MOUSE
θ value	1.80886e-08 (rank : 12)	NC score	0.524876 (rank : 19)
Query Neighborhood Hits	293	Target Neighborhood Hits	118	Shared Neighborhood Hits	98
SwissProt Accessions	P63254, P04006, Q3THF0	Gene names	Crip1, Crip
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP).

DBNL_MOUSE
θ value	1.80886e-08 (rank : 13)	NC score	0.514473 (rank : 26)
Query Neighborhood Hits	293	Target Neighborhood Hits	306	Shared Neighborhood Hits	137
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

VINEX_MOUSE
θ value	3.08544e-08 (rank : 14)	NC score	0.563990 (rank : 8)
Query Neighborhood Hits	293	Target Neighborhood Hits	286	Shared Neighborhood Hits	173
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_HUMAN
θ value	5.26297e-08 (rank : 15)	NC score	0.547209 (rank : 11)
Query Neighborhood Hits	293	Target Neighborhood Hits	396	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	5.26297e-08 (rank : 16)	NC score	0.541152 (rank : 14)
Query Neighborhood Hits	293	Target Neighborhood Hits	409	Shared Neighborhood Hits	168
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ABI2_HUMAN
θ value	8.97725e-08 (rank : 17)	NC score	0.538197 (rank : 15)
Query Neighborhood Hits	293	Target Neighborhood Hits	350	Shared Neighborhood Hits	156
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	8.97725e-08 (rank : 18)	NC score	0.543319 (rank : 12)
Query Neighborhood Hits	293	Target Neighborhood Hits	266	Shared Neighborhood Hits	154
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PACN1_HUMAN
θ value	1.17247e-07 (rank : 19)	NC score	0.515183 (rank : 25)
Query Neighborhood Hits	293	Target Neighborhood Hits	320	Shared Neighborhood Hits	156
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	1.17247e-07 (rank : 20)	NC score	0.518241 (rank : 24)
Query Neighborhood Hits	293	Target Neighborhood Hits	283	Shared Neighborhood Hits	156
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CRIP2_HUMAN
θ value	1.53129e-07 (rank : 21)	NC score	0.473489 (rank : 48)
Query Neighborhood Hits	293	Target Neighborhood Hits	113	Shared Neighborhood Hits	90
SwissProt Accessions	P52943	Gene names	CRIP2, CRP2
Domain Architecture
Description	Cysteine-rich protein 2 (CRP2) (Protein ESP1).

CRIP2_MOUSE
θ value	1.53129e-07 (rank : 22)	NC score	0.470826 (rank : 49)
Query Neighborhood Hits	293	Target Neighborhood Hits	98	Shared Neighborhood Hits	89
SwissProt Accessions	Q9DCT8	Gene names	Crip2, Crp2, Hlp
Domain Architecture
Description	Cysteine-rich protein 2 (CRP2) (Heart LIM protein).

PACN2_HUMAN
θ value	1.53129e-07 (rank : 23)	NC score	0.518251 (rank : 23)
Query Neighborhood Hits	293	Target Neighborhood Hits	339	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	1.53129e-07 (rank : 24)	NC score	0.520775 (rank : 21)
Query Neighborhood Hits	293	Target Neighborhood Hits	382	Shared Neighborhood Hits	160
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABI1_MOUSE
θ value	4.45536e-07 (rank : 25)	NC score	0.534366 (rank : 17)
Query Neighborhood Hits	293	Target Neighborhood Hits	246	Shared Neighborhood Hits	149
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PPIP1_HUMAN
θ value	4.45536e-07 (rank : 26)	NC score	0.495577 (rank : 34)
Query Neighborhood Hits	293	Target Neighborhood Hits	389	Shared Neighborhood Hits	172
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI1_HUMAN
θ value	7.59969e-07 (rank : 27)	NC score	0.520504 (rank : 22)
Query Neighborhood Hits	293	Target Neighborhood Hits	257	Shared Neighborhood Hits	149
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PACN3_MOUSE
θ value	7.59969e-07 (rank : 28)	NC score	0.501532 (rank : 29)
Query Neighborhood Hits	293	Target Neighborhood Hits	380	Shared Neighborhood Hits	152
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PPIP1_MOUSE
θ value	9.92553e-07 (rank : 29)	NC score	0.501740 (rank : 28)
Query Neighborhood Hits	293	Target Neighborhood Hits	377	Shared Neighborhood Hits	172
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CSRP3_HUMAN
θ value	1.29631e-06 (rank : 30)	NC score	0.482938 (rank : 41)
Query Neighborhood Hits	293	Target Neighborhood Hits	150	Shared Neighborhood Hits	106
SwissProt Accessions	P50461, Q9P131	Gene names	CSRP3, CLP, MLP
Domain Architecture
Description	Cysteine and glycine-rich protein 3 (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein).

CSRP3_MOUSE
θ value	1.29631e-06 (rank : 31)	NC score	0.482336 (rank : 43)
Query Neighborhood Hits	293	Target Neighborhood Hits	146	Shared Neighborhood Hits	106
SwissProt Accessions	P50462	Gene names	Csrp3, Clp, Mlp
Domain Architecture
Description	Cysteine and glycine-rich protein 3 (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein).

HCLS1_MOUSE
θ value	1.29631e-06 (rank : 32)	NC score	0.541444 (rank : 13)
Query Neighborhood Hits	293	Target Neighborhood Hits	329	Shared Neighborhood Hits	147
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PACN3_HUMAN
θ value	1.29631e-06 (rank : 33)	NC score	0.498084 (rank : 33)
Query Neighborhood Hits	293	Target Neighborhood Hits	385	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SRC_HUMAN
θ value	1.29631e-06 (rank : 34)	NC score	0.153991 (rank : 277)
Query Neighborhood Hits	293	Target Neighborhood Hits	1058	Shared Neighborhood Hits	156
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

CRIP3_MOUSE
θ value	6.43352e-06 (rank : 35)	NC score	0.441064 (rank : 56)
Query Neighborhood Hits	293	Target Neighborhood Hits	94	Shared Neighborhood Hits	81
SwissProt Accessions	Q6Q6R3, Q91V23, Q91V60	Gene names	Crip3, Tlp
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 3 (CRP3) (Thymus LIM protein) (m17TLP).

LIMA1_MOUSE
θ value	6.43352e-06 (rank : 36)	NC score	0.392047 (rank : 77)
Query Neighborhood Hits	293	Target Neighborhood Hits	298	Shared Neighborhood Hits	102
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

LIMD2_HUMAN
θ value	6.43352e-06 (rank : 37)	NC score	0.463758 (rank : 51)
Query Neighborhood Hits	293	Target Neighborhood Hits	106	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BT23, Q96S91	Gene names	LIMD2
Domain Architecture	No domain graphic available
Description	LIM domain-containing protein 2.

LIMD2_MOUSE
θ value	6.43352e-06 (rank : 38)	NC score	0.462569 (rank : 52)
Query Neighborhood Hits	293	Target Neighborhood Hits	107	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BGB5	Gene names	Limd2
Domain Architecture	No domain graphic available
Description	LIM domain-containing protein 2.

SH3G3_MOUSE
θ value	8.40245e-06 (rank : 39)	NC score	0.513224 (rank : 27)
Query Neighborhood Hits	293	Target Neighborhood Hits	236	Shared Neighborhood Hits	151
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

HCLS1_HUMAN
θ value	1.09739e-05 (rank : 40)	NC score	0.535480 (rank : 16)
Query Neighborhood Hits	293	Target Neighborhood Hits	358	Shared Neighborhood Hits	148
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G3_HUMAN
θ value	1.09739e-05 (rank : 41)	NC score	0.499424 (rank : 32)
Query Neighborhood Hits	293	Target Neighborhood Hits	222	Shared Neighborhood Hits	149
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRIP3_HUMAN
θ value	1.43324e-05 (rank : 42)	NC score	0.463987 (rank : 50)
Query Neighborhood Hits	293	Target Neighborhood Hits	104	Shared Neighborhood Hits	90
SwissProt Accessions	Q6Q6R5, Q5T043, Q6Q6R4, Q6Q6R6, Q6Q6R7	Gene names	CRIP3
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 3 (CRP3) (Chromosome 6 LIM-only protein) (h6LIMo).

CSRP2_HUMAN
θ value	1.43324e-05 (rank : 43)	NC score	0.481703 (rank : 45)
Query Neighborhood Hits	293	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	Q16527, Q93030	Gene names	CSRP2, LMO5, SMLIM
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Smooth muscle cell LIM protein) (SmLIM) (LIM-only protein 5).

CSRP2_MOUSE
θ value	1.43324e-05 (rank : 44)	NC score	0.482212 (rank : 44)
Query Neighborhood Hits	293	Target Neighborhood Hits	152	Shared Neighborhood Hits	107
SwissProt Accessions	P97314, Q9CZG5	Gene names	Csrp2, Dlp1
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Double LIM protein 1) (DLP-1).

SH3G2_HUMAN
θ value	1.43324e-05 (rank : 45)	NC score	0.501363 (rank : 30)
Query Neighborhood Hits	293	Target Neighborhood Hits	324	Shared Neighborhood Hits	153
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CSRP1_HUMAN
θ value	1.87187e-05 (rank : 46)	NC score	0.482558 (rank : 42)
Query Neighborhood Hits	293	Target Neighborhood Hits	128	Shared Neighborhood Hits	106
SwissProt Accessions	P21291	Gene names	CSRP1, CSRP, CYRP
Domain Architecture
Description	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP1) (CRP).

SRC_MOUSE
θ value	1.87187e-05 (rank : 47)	NC score	0.136859 (rank : 294)
Query Neighborhood Hits	293	Target Neighborhood Hits	1033	Shared Neighborhood Hits	145
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SH3G2_MOUSE
θ value	2.44474e-05 (rank : 48)	NC score	0.493683 (rank : 36)
Query Neighborhood Hits	293	Target Neighborhood Hits	319	Shared Neighborhood Hits	149
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

CSRP1_MOUSE
θ value	4.1701e-05 (rank : 49)	NC score	0.481441 (rank : 46)
Query Neighborhood Hits	293	Target Neighborhood Hits	132	Shared Neighborhood Hits	106
SwissProt Accessions	P97315	Gene names	Csrp1, Crp1, Csrp
Domain Architecture
Description	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP1) (CRP).

ITSN2_HUMAN
θ value	4.1701e-05 (rank : 50)	NC score	0.336960 (rank : 125)
Query Neighborhood Hits	293	Target Neighborhood Hits	1173	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	4.1701e-05 (rank : 51)	NC score	0.320146 (rank : 140)
Query Neighborhood Hits	293	Target Neighborhood Hits	1371	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ABLM2_MOUSE
θ value	5.44631e-05 (rank : 52)	NC score	0.386599 (rank : 82)
Query Neighborhood Hits	293	Target Neighborhood Hits	306	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BL65, Q6H8P8, Q80WK6, Q8BUT1, Q8BXI7	Gene names	Ablim2
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 2 (Actin-binding LIM protein family member 2) (abLIM-2).

FYN_HUMAN
θ value	5.44631e-05 (rank : 53)	NC score	0.154469 (rank : 276)
Query Neighborhood Hits	293	Target Neighborhood Hits	1078	Shared Neighborhood Hits	161
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	5.44631e-05 (rank : 54)	NC score	0.157477 (rank : 271)
Query Neighborhood Hits	293	Target Neighborhood Hits	1073	Shared Neighborhood Hits	161
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LIMA1_HUMAN
θ value	5.44631e-05 (rank : 55)	NC score	0.381937 (rank : 88)
Query Neighborhood Hits	293	Target Neighborhood Hits	309	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

MICA3_HUMAN
θ value	5.44631e-05 (rank : 56)	NC score	0.251986 (rank : 196)
Query Neighborhood Hits	293	Target Neighborhood Hits	160	Shared Neighborhood Hits	86
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

MYO1F_HUMAN
θ value	5.44631e-05 (rank : 57)	NC score	0.211021 (rank : 225)
Query Neighborhood Hits	293	Target Neighborhood Hits	275	Shared Neighborhood Hits	146
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	5.44631e-05 (rank : 58)	NC score	0.210283 (rank : 227)
Query Neighborhood Hits	293	Target Neighborhood Hits	262	Shared Neighborhood Hits	147
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SH3G1_HUMAN
θ value	5.44631e-05 (rank : 59)	NC score	0.483522 (rank : 39)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	152
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ITSN1_MOUSE
θ value	7.1131e-05 (rank : 60)	NC score	0.314758 (rank : 142)
Query Neighborhood Hits	293	Target Neighborhood Hits	1669	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PDLI4_HUMAN
θ value	9.29e-05 (rank : 61)	NC score	0.296294 (rank : 154)
Query Neighborhood Hits	293	Target Neighborhood Hits	245	Shared Neighborhood Hits	99
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

ABLM1_MOUSE
θ value	0.000121331 (rank : 62)	NC score	0.378697 (rank : 92)
Query Neighborhood Hits	293	Target Neighborhood Hits	356	Shared Neighborhood Hits	104
SwissProt Accessions	Q8K4G5, Q80U86, Q8BIR9, Q8K4G3, Q8K4G4	Gene names	Ablim1, Ablim, Kiaa0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1).

ABLM2_HUMAN
θ value	0.000121331 (rank : 63)	NC score	0.384036 (rank : 84)
Query Neighborhood Hits	293	Target Neighborhood Hits	317	Shared Neighborhood Hits	103
SwissProt Accessions	Q6H8Q1, Q6H8Q0, Q6NX73, Q8N3C5, Q8N9E9, Q8N9G2, Q96JL7	Gene names	ABLIM2, KIAA1808
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 2 (Actin-binding LIM protein family member 2) (abLIM-2).

MICA1_HUMAN
θ value	0.000121331 (rank : 64)	NC score	0.227660 (rank : 213)
Query Neighborhood Hits	293	Target Neighborhood Hits	279	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

PDLI7_MOUSE
θ value	0.000121331 (rank : 65)	NC score	0.383591 (rank : 86)
Query Neighborhood Hits	293	Target Neighborhood Hits	279	Shared Neighborhood Hits	105
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

STAM1_MOUSE
θ value	0.000121331 (rank : 66)	NC score	0.419379 (rank : 62)
Query Neighborhood Hits	293	Target Neighborhood Hits	273	Shared Neighborhood Hits	149
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABLM1_HUMAN
θ value	0.000158464 (rank : 67)	NC score	0.373598 (rank : 94)
Query Neighborhood Hits	293	Target Neighborhood Hits	387	Shared Neighborhood Hits	103
SwissProt Accessions	O14639, Q15039, Q68CQ9, Q9BUP1	Gene names	ABLIM1, ABLIM, KIAA0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1) (Actin-binding double-zinc-finger protein) (LIMAB1) (Limatin).

ABLM3_MOUSE
θ value	0.000158464 (rank : 68)	NC score	0.390334 (rank : 78)
Query Neighborhood Hits	293	Target Neighborhood Hits	294	Shared Neighborhood Hits	108
SwissProt Accessions	Q69ZX8, Q52KR1, Q6PAI7	Gene names	Ablim3, Kiaa0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

OSTF1_MOUSE
θ value	0.000158464 (rank : 69)	NC score	0.362737 (rank : 106)
Query Neighborhood Hits	293	Target Neighborhood Hits	467	Shared Neighborhood Hits	156
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ABLM3_HUMAN
θ value	0.00020696 (rank : 70)	NC score	0.389442 (rank : 79)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	108
SwissProt Accessions	O94929, Q658S1, Q68CI5, Q9BV32	Gene names	ABLIM3, KIAA0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

ANM2_HUMAN
θ value	0.00020696 (rank : 71)	NC score	0.262409 (rank : 184)
Query Neighborhood Hits	293	Target Neighborhood Hits	175	Shared Neighborhood Hits	126
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

M3KL4_HUMAN
θ value	0.00020696 (rank : 72)	NC score	0.146968 (rank : 286)
Query Neighborhood Hits	293	Target Neighborhood Hits	1087	Shared Neighborhood Hits	152
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

OSTF1_HUMAN
θ value	0.00020696 (rank : 73)	NC score	0.370560 (rank : 96)
Query Neighborhood Hits	293	Target Neighborhood Hits	466	Shared Neighborhood Hits	155
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PDLI4_MOUSE
θ value	0.00020696 (rank : 74)	NC score	0.293419 (rank : 159)
Query Neighborhood Hits	293	Target Neighborhood Hits	233	Shared Neighborhood Hits	99
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

RASA1_HUMAN
θ value	0.00020696 (rank : 75)	NC score	0.176074 (rank : 254)
Query Neighborhood Hits	293	Target Neighborhood Hits	258	Shared Neighborhood Hits	68
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

STAM1_HUMAN
θ value	0.00020696 (rank : 76)	NC score	0.416785 (rank : 64)
Query Neighborhood Hits	293	Target Neighborhood Hits	271	Shared Neighborhood Hits	150
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ITSN1_HUMAN
θ value	0.000270298 (rank : 77)	NC score	0.311499 (rank : 145)
Query Neighborhood Hits	293	Target Neighborhood Hits	1757	Shared Neighborhood Hits	182
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NCF1_MOUSE
θ value	0.00035302 (rank : 78)	NC score	0.416984 (rank : 63)
Query Neighborhood Hits	293	Target Neighborhood Hits	198	Shared Neighborhood Hits	140
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3G1_MOUSE
θ value	0.00035302 (rank : 79)	NC score	0.475486 (rank : 47)
Query Neighborhood Hits	293	Target Neighborhood Hits	291	Shared Neighborhood Hits	149
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STS1_MOUSE
θ value	0.000461057 (rank : 80)	NC score	0.269319 (rank : 177)
Query Neighborhood Hits	293	Target Neighborhood Hits	104	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

VAV_MOUSE
θ value	0.000461057 (rank : 81)	NC score	0.348901 (rank : 118)
Query Neighborhood Hits	293	Target Neighborhood Hits	430	Shared Neighborhood Hits	162
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG7_HUMAN
θ value	0.000602161 (rank : 82)	NC score	0.400037 (rank : 71)
Query Neighborhood Hits	293	Target Neighborhood Hits	347	Shared Neighborhood Hits	158
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	0.000602161 (rank : 83)	NC score	0.405591 (rank : 68)
Query Neighborhood Hits	293	Target Neighborhood Hits	396	Shared Neighborhood Hits	158
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CD2AP_HUMAN
θ value	0.000602161 (rank : 84)	NC score	0.494785 (rank : 35)
Query Neighborhood Hits	293	Target Neighborhood Hits	315	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	0.000602161 (rank : 85)	NC score	0.500799 (rank : 31)
Query Neighborhood Hits	293	Target Neighborhood Hits	336	Shared Neighborhood Hits	165
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PDLI7_HUMAN
θ value	0.000602161 (rank : 86)	NC score	0.370913 (rank : 95)
Query Neighborhood Hits	293	Target Neighborhood Hits	547	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

FHL2_MOUSE
θ value	0.000786445 (rank : 87)	NC score	0.297230 (rank : 152)
Query Neighborhood Hits	293	Target Neighborhood Hits	539	Shared Neighborhood Hits	99
SwissProt Accessions	O70433, P97448	Gene names	Fhl2
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3).

AHI1_MOUSE
θ value	0.00102713 (rank : 88)	NC score	0.327019 (rank : 132)
Query Neighborhood Hits	293	Target Neighborhood Hits	496	Shared Neighborhood Hits	157
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

STS1_HUMAN
θ value	0.00102713 (rank : 89)	NC score	0.267783 (rank : 178)
Query Neighborhood Hits	293	Target Neighborhood Hits	106	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ANM2_MOUSE
θ value	0.00134147 (rank : 90)	NC score	0.248842 (rank : 198)
Query Neighborhood Hits	293	Target Neighborhood Hits	175	Shared Neighborhood Hits	124
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FGR_HUMAN
θ value	0.00134147 (rank : 91)	NC score	0.153058 (rank : 278)
Query Neighborhood Hits	293	Target Neighborhood Hits	1067	Shared Neighborhood Hits	155
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MICA2_HUMAN
θ value	0.00134147 (rank : 92)	NC score	0.221906 (rank : 217)
Query Neighborhood Hits	293	Target Neighborhood Hits	174	Shared Neighborhood Hits	82
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

MICA3_MOUSE
θ value	0.00134147 (rank : 93)	NC score	0.199590 (rank : 234)
Query Neighborhood Hits	293	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CJ19, Q80TE8, Q8BXB1	Gene names	Mical3, Kiaa1364
Domain Architecture
Description	Protein MICAL-3.

ARHGG_HUMAN
θ value	0.00175202 (rank : 94)	NC score	0.173424 (rank : 255)
Query Neighborhood Hits	293	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DDEF1_MOUSE
θ value	0.00175202 (rank : 95)	NC score	0.232287 (rank : 209)
Query Neighborhood Hits	293	Target Neighborhood Hits	592	Shared Neighborhood Hits	131
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FHL2_HUMAN
θ value	0.00175202 (rank : 96)	NC score	0.308124 (rank : 148)
Query Neighborhood Hits	293	Target Neighborhood Hits	533	Shared Neighborhood Hits	101
SwissProt Accessions	Q14192, Q13229, Q13644, Q9P294	Gene names	FHL2, DRAL, SLIM3
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3) (LIM-domain protein DRAL).

GRAP2_MOUSE
θ value	0.00175202 (rank : 97)	NC score	0.439228 (rank : 57)
Query Neighborhood Hits	293	Target Neighborhood Hits	297	Shared Neighborhood Hits	161
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

MICA2_MOUSE
θ value	0.00175202 (rank : 98)	NC score	0.225037 (rank : 215)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BML1, Q3UPU6	Gene names	Mical2
Domain Architecture
Description	Protein MICAL-2.

PRIC2_HUMAN
θ value	0.00175202 (rank : 99)	NC score	0.350619 (rank : 116)
Query Neighborhood Hits	293	Target Neighborhood Hits	197	Shared Neighborhood Hits	104
SwissProt Accessions	Q7Z3G6	Gene names	PRICKLE2
Domain Architecture	No domain graphic available
Description	Prickle-like protein 2.

PRIC2_MOUSE
θ value	0.00175202 (rank : 100)	NC score	0.349858 (rank : 117)
Query Neighborhood Hits	293	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q80Y24	Gene names	Prickle2
Domain Architecture	No domain graphic available
Description	Prickle-like protein 2.

SH3K1_HUMAN
θ value	0.00175202 (rank : 101)	NC score	0.491861 (rank : 37)
Query Neighborhood Hits	293	Target Neighborhood Hits	341	Shared Neighborhood Hits	160
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.00175202 (rank : 102)	NC score	0.490890 (rank : 38)
Query Neighborhood Hits	293	Target Neighborhood Hits	332	Shared Neighborhood Hits	162
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

LMX1A_MOUSE
θ value	0.00228821 (rank : 103)	NC score	0.259569 (rank : 185)
Query Neighborhood Hits	293	Target Neighborhood Hits	405	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JKU8	Gene names	Lmx1a
Domain Architecture
Description	LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1).

AMPH_HUMAN
θ value	0.00298849 (rank : 104)	NC score	0.212922 (rank : 224)
Query Neighborhood Hits	293	Target Neighborhood Hits	455	Shared Neighborhood Hits	84
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ARHGG_MOUSE
θ value	0.00298849 (rank : 105)	NC score	0.191613 (rank : 242)
Query Neighborhood Hits	293	Target Neighborhood Hits	152	Shared Neighborhood Hits	66
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

LIMK1_MOUSE
θ value	0.00298849 (rank : 106)	NC score	0.156156 (rank : 273)
Query Neighborhood Hits	293	Target Neighborhood Hits	1008	Shared Neighborhood Hits	134
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LMO6_MOUSE
θ value	0.00298849 (rank : 107)	NC score	0.328507 (rank : 129)
Query Neighborhood Hits	293	Target Neighborhood Hits	277	Shared Neighborhood Hits	93
SwissProt Accessions	Q80VL3, Q8CAY9	Gene names	Lmo6
Domain Architecture	No domain graphic available
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

MICA1_MOUSE
θ value	0.00298849 (rank : 108)	NC score	0.202749 (rank : 233)
Query Neighborhood Hits	293	Target Neighborhood Hits	400	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MYO1E_HUMAN
θ value	0.00298849 (rank : 109)	NC score	0.203596 (rank : 232)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	157
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

P85A_MOUSE
θ value	0.00298849 (rank : 110)	NC score	0.197500 (rank : 236)
Query Neighborhood Hits	293	Target Neighborhood Hits	435	Shared Neighborhood Hits	108
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PINC_HUMAN
θ value	0.00298849 (rank : 111)	NC score	0.399649 (rank : 72)
Query Neighborhood Hits	293	Target Neighborhood Hits	231	Shared Neighborhood Hits	101
SwissProt Accessions	P48059, Q53TE0, Q9BS44	Gene names	LIMS1
Domain Architecture
Description	Protein PINCH (Particularly interesting new Cys-His protein) (LIM and senescent cell antigen-like domains 1) (NY-REN-48 antigen).

SHLB2_MOUSE
θ value	0.00298849 (rank : 112)	NC score	0.275012 (rank : 169)
Query Neighborhood Hits	293	Target Neighborhood Hits	88	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

DDEF2_HUMAN
θ value	0.00390308 (rank : 113)	NC score	0.213110 (rank : 223)
Query Neighborhood Hits	293	Target Neighborhood Hits	599	Shared Neighborhood Hits	131
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.00390308 (rank : 114)	NC score	0.214233 (rank : 222)
Query Neighborhood Hits	293	Target Neighborhood Hits	625	Shared Neighborhood Hits	131
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PDLI5_HUMAN
θ value	0.00390308 (rank : 115)	NC score	0.368492 (rank : 101)
Query Neighborhood Hits	293	Target Neighborhood Hits	322	Shared Neighborhood Hits	102
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	0.00390308 (rank : 116)	NC score	0.369041 (rank : 99)
Query Neighborhood Hits	293	Target Neighborhood Hits	287	Shared Neighborhood Hits	101
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PEX13_HUMAN
θ value	0.00390308 (rank : 117)	NC score	0.359921 (rank : 107)
Query Neighborhood Hits	293	Target Neighborhood Hits	128	Shared Neighborhood Hits	106
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC1_MOUSE
θ value	0.00390308 (rank : 118)	NC score	0.293459 (rank : 158)
Query Neighborhood Hits	293	Target Neighborhood Hits	206	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SNX18_HUMAN
θ value	0.00390308 (rank : 119)	NC score	0.336094 (rank : 127)
Query Neighborhood Hits	293	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.00390308 (rank : 120)	NC score	0.338446 (rank : 123)
Query Neighborhood Hits	293	Target Neighborhood Hits	198	Shared Neighborhood Hits	120
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

STS2_HUMAN
θ value	0.00390308 (rank : 121)	NC score	0.294692 (rank : 157)
Query Neighborhood Hits	293	Target Neighborhood Hits	108	Shared Neighborhood Hits	89
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TRIP6_HUMAN
θ value	0.00390308 (rank : 122)	NC score	0.355822 (rank : 112)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	95
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

YES_MOUSE
θ value	0.00390308 (rank : 123)	NC score	0.148041 (rank : 284)
Query Neighborhood Hits	293	Target Neighborhood Hits	1052	Shared Neighborhood Hits	151
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BAIP2_HUMAN
θ value	0.00509761 (rank : 124)	NC score	0.188919 (rank : 246)
Query Neighborhood Hits	293	Target Neighborhood Hits	192	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.00509761 (rank : 125)	NC score	0.189874 (rank : 244)
Query Neighborhood Hits	293	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

FHL3_MOUSE
θ value	0.00509761 (rank : 126)	NC score	0.374018 (rank : 93)
Query Neighborhood Hits	293	Target Neighborhood Hits	424	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R059, Q9JLP5, Q9WUH3	Gene names	Fhl3
Domain Architecture
Description	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2).

GRAP2_HUMAN
θ value	0.00509761 (rank : 127)	NC score	0.428597 (rank : 60)
Query Neighborhood Hits	293	Target Neighborhood Hits	304	Shared Neighborhood Hits	158
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

LHX61_HUMAN
θ value	0.00509761 (rank : 128)	NC score	0.256501 (rank : 187)
Query Neighborhood Hits	293	Target Neighborhood Hits	412	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UPM6, Q5T7S8, Q9NTK3, Q9UPM5	Gene names	LHX6, LHX6.1
Domain Architecture
Description	LIM/homeobox protein Lhx6.1 (Lhx6).

LHX61_MOUSE
θ value	0.00509761 (rank : 129)	NC score	0.264787 (rank : 181)
Query Neighborhood Hits	293	Target Neighborhood Hits	396	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R1R0, Q9R1R1	Gene names	Lhx6.1
Domain Architecture
Description	LIM/homeobox protein Lhx6.1.

LHX9_HUMAN
θ value	0.00509761 (rank : 130)	NC score	0.269850 (rank : 175)
Query Neighborhood Hits	293	Target Neighborhood Hits	444	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NQ69, Q5VUE3, Q9BYU6, Q9NQ70	Gene names	LHX9
Domain Architecture
Description	LIM/homeobox protein Lhx9.

LHX9_MOUSE
θ value	0.00509761 (rank : 131)	NC score	0.269707 (rank : 176)
Query Neighborhood Hits	293	Target Neighborhood Hits	445	Shared Neighborhood Hits	102
SwissProt Accessions	Q9WUH2, Q9QYQ5, Q9QYQ6, Q9QZ00, Q9WU44	Gene names	Lhx9
Domain Architecture
Description	LIM/homeobox protein Lhx9.

LIMK1_HUMAN
θ value	0.00509761 (rank : 132)	NC score	0.155611 (rank : 275)
Query Neighborhood Hits	293	Target Neighborhood Hits	1005	Shared Neighborhood Hits	135
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LMO6_HUMAN
θ value	0.00509761 (rank : 133)	NC score	0.327368 (rank : 131)
Query Neighborhood Hits	293	Target Neighborhood Hits	337	Shared Neighborhood Hits	103
SwissProt Accessions	O43900, O76007	Gene names	LMO6
Domain Architecture
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

NCF2_HUMAN
θ value	0.00509761 (rank : 134)	NC score	0.483487 (rank : 40)
Query Neighborhood Hits	293	Target Neighborhood Hits	229	Shared Neighborhood Hits	151
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PAXI_HUMAN
θ value	0.00509761 (rank : 135)	NC score	0.393288 (rank : 75)
Query Neighborhood Hits	293	Target Neighborhood Hits	173	Shared Neighborhood Hits	101
SwissProt Accessions	P49023, O14970, O14971, O60360	Gene names	PXN
Domain Architecture
Description	Paxillin.

PAXI_MOUSE
θ value	0.00509761 (rank : 136)	NC score	0.393587 (rank : 73)
Query Neighborhood Hits	293	Target Neighborhood Hits	176	Shared Neighborhood Hits	101
SwissProt Accessions	Q8VI36, Q3TB62, Q3TZQ6, Q8VI37	Gene names	Pxn
Domain Architecture	No domain graphic available
Description	Paxillin.

PDLI3_HUMAN
θ value	0.00509761 (rank : 137)	NC score	0.266674 (rank : 179)
Query Neighborhood Hits	293	Target Neighborhood Hits	199	Shared Neighborhood Hits	92
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	0.00509761 (rank : 138)	NC score	0.265001 (rank : 180)
Query Neighborhood Hits	293	Target Neighborhood Hits	197	Shared Neighborhood Hits	92
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SHLB2_HUMAN
θ value	0.00509761 (rank : 139)	NC score	0.271964 (rank : 174)
Query Neighborhood Hits	293	Target Neighborhood Hits	86	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

TES_HUMAN
θ value	0.00509761 (rank : 140)	NC score	0.346030 (rank : 121)
Query Neighborhood Hits	293	Target Neighborhood Hits	131	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UGI8, Q9GZQ1, Q9HAJ9	Gene names	TES
Domain Architecture
Description	Testin (TESS).

VAV_HUMAN
θ value	0.00509761 (rank : 141)	NC score	0.347663 (rank : 119)
Query Neighborhood Hits	293	Target Neighborhood Hits	452	Shared Neighborhood Hits	160
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

YES_HUMAN
θ value	0.00509761 (rank : 142)	NC score	0.146906 (rank : 287)
Query Neighborhood Hits	293	Target Neighborhood Hits	1059	Shared Neighborhood Hits	153
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ABI3_MOUSE
θ value	0.00665767 (rank : 143)	NC score	0.462451 (rank : 53)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

FBLI1_HUMAN
θ value	0.00665767 (rank : 144)	NC score	0.383409 (rank : 87)
Query Neighborhood Hits	293	Target Neighborhood Hits	200	Shared Neighborhood Hits	106
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

LIMD1_HUMAN
θ value	0.00665767 (rank : 145)	NC score	0.365510 (rank : 104)
Query Neighborhood Hits	293	Target Neighborhood Hits	201	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

LIMD1_MOUSE
θ value	0.00665767 (rank : 146)	NC score	0.359872 (rank : 108)
Query Neighborhood Hits	293	Target Neighborhood Hits	291	Shared Neighborhood Hits	108
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

LPP_MOUSE
θ value	0.00665767 (rank : 147)	NC score	0.350730 (rank : 115)
Query Neighborhood Hits	293	Target Neighborhood Hits	247	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

LPXN_HUMAN
θ value	0.00665767 (rank : 148)	NC score	0.393537 (rank : 74)
Query Neighborhood Hits	293	Target Neighborhood Hits	159	Shared Neighborhood Hits	101
SwissProt Accessions	O60711	Gene names	LPXN, LDLP
Domain Architecture
Description	Leupaxin.

M3K10_HUMAN
θ value	0.00665767 (rank : 149)	NC score	0.121505 (rank : 305)
Query Neighborhood Hits	293	Target Neighborhood Hits	1071	Shared Neighborhood Hits	139
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

NCF1_HUMAN
θ value	0.00665767 (rank : 150)	NC score	0.406031 (rank : 67)
Query Neighborhood Hits	293	Target Neighborhood Hits	198	Shared Neighborhood Hits	137
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

RHG26_HUMAN
θ value	0.00665767 (rank : 151)	NC score	0.231956 (rank : 210)
Query Neighborhood Hits	293	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SHLB1_MOUSE
θ value	0.00665767 (rank : 152)	NC score	0.298657 (rank : 151)
Query Neighborhood Hits	293	Target Neighborhood Hits	101	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ABI3_HUMAN
θ value	0.00869519 (rank : 153)	NC score	0.460301 (rank : 54)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	126
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG6_HUMAN
θ value	0.00869519 (rank : 154)	NC score	0.379935 (rank : 90)
Query Neighborhood Hits	293	Target Neighborhood Hits	376	Shared Neighborhood Hits	154
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

HCK_MOUSE
θ value	0.00869519 (rank : 155)	NC score	0.131987 (rank : 296)
Query Neighborhood Hits	293	Target Neighborhood Hits	1029	Shared Neighborhood Hits	151
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

P85A_HUMAN
θ value	0.00869519 (rank : 156)	NC score	0.187548 (rank : 249)
Query Neighborhood Hits	293	Target Neighborhood Hits	479	Shared Neighborhood Hits	102
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

AHI1_HUMAN
θ value	0.0113563 (rank : 157)	NC score	0.318648 (rank : 141)
Query Neighborhood Hits	293	Target Neighborhood Hits	537	Shared Neighborhood Hits	153
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

BIN1_HUMAN
θ value	0.0113563 (rank : 158)	NC score	0.208958 (rank : 228)
Query Neighborhood Hits	293	Target Neighborhood Hits	335	Shared Neighborhood Hits	74
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

DOCK1_HUMAN
θ value	0.0113563 (rank : 159)	NC score	0.163874 (rank : 267)
Query Neighborhood Hits	293	Target Neighborhood Hits	191	Shared Neighborhood Hits	109
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

FGR_MOUSE
θ value	0.0113563 (rank : 160)	NC score	0.146566 (rank : 288)
Query Neighborhood Hits	293	Target Neighborhood Hits	1069	Shared Neighborhood Hits	155
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FHL5_HUMAN
θ value	0.0113563 (rank : 161)	NC score	0.322293 (rank : 134)
Query Neighborhood Hits	293	Target Neighborhood Hits	523	Shared Neighborhood Hits	102
SwissProt Accessions	Q5TD97, Q5TD98, Q8WW21, Q9NQU2	Gene names	FHL5, ACT
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

HCK_HUMAN
θ value	0.0113563 (rank : 162)	NC score	0.129581 (rank : 300)
Query Neighborhood Hits	293	Target Neighborhood Hits	1035	Shared Neighborhood Hits	149
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

LPXN_MOUSE
θ value	0.0113563 (rank : 163)	NC score	0.385612 (rank : 83)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	101
SwissProt Accessions	Q99N69	Gene names	Lpxn
Domain Architecture	No domain graphic available
Description	Leupaxin.

MILK2_HUMAN
θ value	0.0113563 (rank : 164)	NC score	0.171936 (rank : 257)
Query Neighborhood Hits	293	Target Neighborhood Hits	457	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

NCF4_HUMAN
θ value	0.0113563 (rank : 165)	NC score	0.429327 (rank : 58)
Query Neighborhood Hits	293	Target Neighborhood Hits	161	Shared Neighborhood Hits	122
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	0.0113563 (rank : 166)	NC score	0.457807 (rank : 55)
Query Neighborhood Hits	293	Target Neighborhood Hits	177	Shared Neighborhood Hits	132
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

TES_MOUSE
θ value	0.0113563 (rank : 167)	NC score	0.341305 (rank : 122)
Query Neighborhood Hits	293	Target Neighborhood Hits	171	Shared Neighborhood Hits	100
SwissProt Accessions	P47226	Gene names	Tes
Domain Architecture
Description	Testin (TES1/TES2).

ARHG6_MOUSE
θ value	0.0148317 (rank : 168)	NC score	0.379885 (rank : 91)
Query Neighborhood Hits	293	Target Neighborhood Hits	394	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CRKL_MOUSE
θ value	0.0148317 (rank : 169)	NC score	0.388549 (rank : 81)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	144
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DNMBP_HUMAN
θ value	0.0148317 (rank : 170)	NC score	0.389123 (rank : 80)
Query Neighborhood Hits	293	Target Neighborhood Hits	413	Shared Neighborhood Hits	169
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRB2_HUMAN
θ value	0.0148317 (rank : 171)	NC score	0.428818 (rank : 59)
Query Neighborhood Hits	293	Target Neighborhood Hits	310	Shared Neighborhood Hits	157
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.0148317 (rank : 172)	NC score	0.427918 (rank : 61)
Query Neighborhood Hits	293	Target Neighborhood Hits	312	Shared Neighborhood Hits	157
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

LDB3_HUMAN
θ value	0.0148317 (rank : 173)	NC score	0.355174 (rank : 113)
Query Neighborhood Hits	293	Target Neighborhood Hits	497	Shared Neighborhood Hits	110
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	0.0148317 (rank : 174)	NC score	0.354416 (rank : 114)
Query Neighborhood Hits	293	Target Neighborhood Hits	510	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LPP_HUMAN
θ value	0.0148317 (rank : 175)	NC score	0.310356 (rank : 146)
Query Neighborhood Hits	293	Target Neighborhood Hits	775	Shared Neighborhood Hits	115
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

RUSC1_HUMAN
θ value	0.0148317 (rank : 176)	NC score	0.304122 (rank : 150)
Query Neighborhood Hits	293	Target Neighborhood Hits	226	Shared Neighborhood Hits	114
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

BIN1_MOUSE
θ value	0.0193708 (rank : 177)	NC score	0.210718 (rank : 226)
Query Neighborhood Hits	293	Target Neighborhood Hits	283	Shared Neighborhood Hits	77
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

DNMBP_MOUSE
θ value	0.0193708 (rank : 178)	NC score	0.383658 (rank : 85)
Query Neighborhood Hits	293	Target Neighborhood Hits	435	Shared Neighborhood Hits	172
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FHL5_MOUSE
θ value	0.0193708 (rank : 179)	NC score	0.336698 (rank : 126)
Query Neighborhood Hits	293	Target Neighborhood Hits	463	Shared Neighborhood Hits	103
SwissProt Accessions	Q9WTX7	Gene names	Fhl5, Act
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

LHX5_HUMAN
θ value	0.0193708 (rank : 180)	NC score	0.253749 (rank : 192)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	100
SwissProt Accessions	Q9H2C1	Gene names	LHX5
Domain Architecture
Description	LIM/homeobox protein Lhx5.

LHX5_MOUSE
θ value	0.0193708 (rank : 181)	NC score	0.254750 (rank : 191)
Query Neighborhood Hits	293	Target Neighborhood Hits	456	Shared Neighborhood Hits	100
SwissProt Accessions	P61375, P50459	Gene names	Lhx5
Domain Architecture
Description	LIM/homeobox protein Lhx5.

LMX1A_HUMAN
θ value	0.0193708 (rank : 182)	NC score	0.253047 (rank : 193)
Query Neighborhood Hits	293	Target Neighborhood Hits	406	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TE12, Q8TE11	Gene names	LMX1A
Domain Architecture
Description	LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1).

PEX13_MOUSE
θ value	0.0193708 (rank : 183)	NC score	0.347482 (rank : 120)
Query Neighborhood Hits	293	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PLCG1_MOUSE
θ value	0.0193708 (rank : 184)	NC score	0.312393 (rank : 144)
Query Neighborhood Hits	293	Target Neighborhood Hits	314	Shared Neighborhood Hits	142
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	0.0193708 (rank : 185)	NC score	0.308099 (rank : 149)
Query Neighborhood Hits	293	Target Neighborhood Hits	280	Shared Neighborhood Hits	136
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SHLB1_HUMAN
θ value	0.0193708 (rank : 186)	NC score	0.290765 (rank : 161)
Query Neighborhood Hits	293	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SPN90_MOUSE
θ value	0.0193708 (rank : 187)	NC score	0.218973 (rank : 220)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

BI2L1_HUMAN
θ value	0.0252991 (rank : 188)	NC score	0.185479 (rank : 250)
Query Neighborhood Hits	293	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CRKL_HUMAN
θ value	0.0252991 (rank : 189)	NC score	0.392336 (rank : 76)
Query Neighborhood Hits	293	Target Neighborhood Hits	313	Shared Neighborhood Hits	150
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

LHX8_MOUSE
θ value	0.0252991 (rank : 190)	NC score	0.254872 (rank : 190)
Query Neighborhood Hits	293	Target Neighborhood Hits	406	Shared Neighborhood Hits	93
SwissProt Accessions	O35652, O70163, O88707	Gene names	Lhx8, Lhx7
Domain Architecture
Description	LIM/homeobox protein Lhx8 (LIM homeodomain Lhx7) (L3).

NCK1_HUMAN
θ value	0.0252991 (rank : 191)	NC score	0.408168 (rank : 65)
Query Neighborhood Hits	293	Target Neighborhood Hits	312	Shared Neighborhood Hits	162
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PRIC1_HUMAN
θ value	0.0252991 (rank : 192)	NC score	0.337372 (rank : 124)
Query Neighborhood Hits	293	Target Neighborhood Hits	187	Shared Neighborhood Hits	98
SwissProt Accessions	Q96MT3, Q71QF8, Q96N00	Gene names	PRICKLE1, RILP
Domain Architecture	No domain graphic available
Description	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1).

SPN90_HUMAN
θ value	0.0252991 (rank : 193)	NC score	0.233033 (rank : 208)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ZYX_MOUSE
θ value	0.0252991 (rank : 194)	NC score	0.359489 (rank : 110)
Query Neighborhood Hits	293	Target Neighborhood Hits	347	Shared Neighborhood Hits	110
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

ARHG5_HUMAN
θ value	0.0330416 (rank : 195)	NC score	0.225245 (rank : 214)
Query Neighborhood Hits	293	Target Neighborhood Hits	172	Shared Neighborhood Hits	96
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

JIP2_HUMAN
θ value	0.0330416 (rank : 196)	NC score	0.170665 (rank : 258)
Query Neighborhood Hits	293	Target Neighborhood Hits	288	Shared Neighborhood Hits	64
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	0.0330416 (rank : 197)	NC score	0.172942 (rank : 256)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ZYX_HUMAN
θ value	0.0330416 (rank : 198)	NC score	0.359539 (rank : 109)
Query Neighborhood Hits	293	Target Neighborhood Hits	387	Shared Neighborhood Hits	110
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

CRK_HUMAN
θ value	0.0431538 (rank : 199)	NC score	0.365011 (rank : 105)
Query Neighborhood Hits	293	Target Neighborhood Hits	308	Shared Neighborhood Hits	151
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0431538 (rank : 200)	NC score	0.368448 (rank : 102)
Query Neighborhood Hits	293	Target Neighborhood Hits	314	Shared Neighborhood Hits	151
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

LHX6_MOUSE
θ value	0.0431538 (rank : 201)	NC score	0.248131 (rank : 201)
Query Neighborhood Hits	293	Target Neighborhood Hits	399	Shared Neighborhood Hits	94
SwissProt Accessions	O88706	Gene names	Lhx6
Domain Architecture
Description	LIM/homeobox protein Lhx6.

M3K11_HUMAN
θ value	0.0431538 (rank : 202)	NC score	0.128356 (rank : 302)
Query Neighborhood Hits	293	Target Neighborhood Hits	1136	Shared Neighborhood Hits	151
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

GRAP_HUMAN
θ value	0.0563607 (rank : 203)	NC score	0.404163 (rank : 70)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	155
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	0.0563607 (rank : 204)	NC score	0.408127 (rank : 66)
Query Neighborhood Hits	293	Target Neighborhood Hits	309	Shared Neighborhood Hits	159
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

LHX1_HUMAN
θ value	0.0563607 (rank : 205)	NC score	0.248730 (rank : 199)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	98
SwissProt Accessions	P48742, Q3MIW0	Gene names	LHX1, LIM1
Domain Architecture
Description	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1).

LHX1_MOUSE
θ value	0.0563607 (rank : 206)	NC score	0.248681 (rank : 200)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	98
SwissProt Accessions	P63006, P36199	Gene names	Lhx1, Lim-1, Lim1
Domain Architecture	No domain graphic available
Description	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1).

SPTA1_HUMAN
θ value	0.0563607 (rank : 207)	NC score	0.157001 (rank : 272)
Query Neighborhood Hits	293	Target Neighborhood Hits	748	Shared Neighborhood Hits	145
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

LHX4_HUMAN
θ value	0.0736092 (rank : 208)	NC score	0.255345 (rank : 188)
Query Neighborhood Hits	293	Target Neighborhood Hits	455	Shared Neighborhood Hits	103
SwissProt Accessions	Q969G2, Q8NHE0, Q8TCJ1, Q8WWX2, Q969W2	Gene names	LHX4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LHX4_MOUSE
θ value	0.0736092 (rank : 209)	NC score	0.255100 (rank : 189)
Query Neighborhood Hits	293	Target Neighborhood Hits	457	Shared Neighborhood Hits	102
SwissProt Accessions	P53776, O08916, Q9R280	Gene names	Lhx4, Gsh-4, Gsh4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LMCD1_HUMAN
θ value	0.0736092 (rank : 210)	NC score	0.313907 (rank : 143)
Query Neighborhood Hits	293	Target Neighborhood Hits	108	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZU5	Gene names	LMCD1
Domain Architecture
Description	LIM and cysteine-rich domains protein 1 (Dyxin).

M3K9_HUMAN
θ value	0.0736092 (rank : 211)	NC score	0.124216 (rank : 303)
Query Neighborhood Hits	293	Target Neighborhood Hits	1123	Shared Neighborhood Hits	149
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

FHL1_HUMAN
θ value	0.0961366 (rank : 212)	NC score	0.327385 (rank : 130)
Query Neighborhood Hits	293	Target Neighborhood Hits	436	Shared Neighborhood Hits	102
SwissProt Accessions	Q13642, O95212, Q13230, Q13645, Q5M7Y6, Q9NZ40, Q9UKZ8, Q9Y630	Gene names	FHL1, SLIM1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM).

LMCD1_MOUSE
θ value	0.0961366 (rank : 213)	NC score	0.308447 (rank : 147)
Query Neighborhood Hits	293	Target Neighborhood Hits	102	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VEE1	Gene names	Lmcd1
Domain Architecture
Description	LIM and cysteine-rich domains protein 1.

NCK2_HUMAN
θ value	0.0961366 (rank : 214)	NC score	0.404482 (rank : 69)
Query Neighborhood Hits	293	Target Neighborhood Hits	310	Shared Neighborhood Hits	159
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PLCG1_HUMAN
θ value	0.0961366 (rank : 215)	NC score	0.296370 (rank : 153)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	137
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

FHL1_MOUSE
θ value	0.125558 (rank : 216)	NC score	0.329423 (rank : 128)
Query Neighborhood Hits	293	Target Neighborhood Hits	462	Shared Neighborhood Hits	104
SwissProt Accessions	P97447, O55181, Q8K318	Gene names	Fhl1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM) (KyoT) (RBP-associated molecule 14-1) (RAM14-1).

FRK_HUMAN
θ value	0.125558 (rank : 217)	NC score	0.117731 (rank : 309)
Query Neighborhood Hits	293	Target Neighborhood Hits	1058	Shared Neighborhood Hits	152
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

VAV2_MOUSE
θ value	0.125558 (rank : 218)	NC score	0.321038 (rank : 137)
Query Neighborhood Hits	293	Target Neighborhood Hits	456	Shared Neighborhood Hits	159
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FBLI1_MOUSE
θ value	0.163984 (rank : 219)	NC score	0.369019 (rank : 100)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	106
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

VAV2_HUMAN
θ value	0.163984 (rank : 220)	NC score	0.320165 (rank : 139)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	158
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ATS20_MOUSE
θ value	0.21417 (rank : 221)	NC score	0.009323 (rank : 458)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

FHL3_HUMAN
θ value	0.21417 (rank : 222)	NC score	0.369564 (rank : 98)
Query Neighborhood Hits	293	Target Neighborhood Hits	354	Shared Neighborhood Hits	104
SwissProt Accessions	Q13643	Gene names	FHL3, SLIM2
Domain Architecture
Description	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2).

LHX3_MOUSE
θ value	0.279714 (rank : 223)	NC score	0.246017 (rank : 202)
Query Neighborhood Hits	293	Target Neighborhood Hits	451	Shared Neighborhood Hits	103
SwissProt Accessions	P50481, Q61800, Q61801	Gene names	Lhx3, Lim-3, Lim3, Plim
Domain Architecture
Description	LIM/homeobox protein Lhx3 (Homeobox protein LIM-3) (Homeobox protein P-LIM) (LIM homeobox protein 3).

VAV3_MOUSE
θ value	0.279714 (rank : 224)	NC score	0.295203 (rank : 156)
Query Neighborhood Hits	293	Target Neighborhood Hits	404	Shared Neighborhood Hits	154
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

MILK1_MOUSE
θ value	0.365318 (rank : 225)	NC score	0.164944 (rank : 264)
Query Neighborhood Hits	293	Target Neighborhood Hits	788	Shared Neighborhood Hits	98
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NGEF_HUMAN
θ value	0.365318 (rank : 226)	NC score	0.192981 (rank : 238)
Query Neighborhood Hits	293	Target Neighborhood Hits	166	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SPTA1_MOUSE
θ value	0.365318 (rank : 227)	NC score	0.157845 (rank : 270)
Query Neighborhood Hits	293	Target Neighborhood Hits	675	Shared Neighborhood Hits	136
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ARHG4_HUMAN
θ value	0.47712 (rank : 228)	NC score	0.257711 (rank : 186)
Query Neighborhood Hits	293	Target Neighborhood Hits	242	Shared Neighborhood Hits	139
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ASPP1_MOUSE
θ value	0.47712 (rank : 229)	NC score	0.192295 (rank : 240)
Query Neighborhood Hits	293	Target Neighborhood Hits	1244	Shared Neighborhood Hits	153
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CSK_HUMAN
θ value	0.47712 (rank : 230)	NC score	0.105863 (rank : 323)
Query Neighborhood Hits	293	Target Neighborhood Hits	1009	Shared Neighborhood Hits	119
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.47712 (rank : 231)	NC score	0.105876 (rank : 322)
Query Neighborhood Hits	293	Target Neighborhood Hits	1009	Shared Neighborhood Hits	119
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

EFS_HUMAN
θ value	0.47712 (rank : 232)	NC score	0.280870 (rank : 168)
Query Neighborhood Hits	293	Target Neighborhood Hits	348	Shared Neighborhood Hits	123
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.47712 (rank : 233)	NC score	0.291997 (rank : 160)
Query Neighborhood Hits	293	Target Neighborhood Hits	389	Shared Neighborhood Hits	134
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ES8L3_MOUSE
θ value	0.47712 (rank : 234)	NC score	0.198893 (rank : 235)
Query Neighborhood Hits	293	Target Neighborhood Hits	168	Shared Neighborhood Hits	119
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

LMO3_HUMAN
θ value	0.47712 (rank : 235)	NC score	0.281353 (rank : 165)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	94
SwissProt Accessions	Q8TAP4, Q8N974, Q9UDD5	Gene names	LMO3, RBTN3, RHOM3
Domain Architecture
Description	LIM-only protein 3 (Neuronal-specific transcription factor DAT1) (Rhombotin-3).

LMO3_MOUSE
θ value	0.47712 (rank : 236)	NC score	0.281353 (rank : 166)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BZL8	Gene names	Lmo3
Domain Architecture
Description	LIM-only protein 3 (Neuronal-specific transcription factor DAT1).

NPHP1_MOUSE
θ value	0.47712 (rank : 237)	NC score	0.323614 (rank : 133)
Query Neighborhood Hits	293	Target Neighborhood Hits	267	Shared Neighborhood Hits	139
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

RBTN1_HUMAN
θ value	0.47712 (rank : 238)	NC score	0.281131 (rank : 167)
Query Neighborhood Hits	293	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	P25800, Q4VBC5	Gene names	LMO1, RBTN1, RHOM1, TTG1
Domain Architecture
Description	Rhombotin-1 (Cysteine-rich protein TTG-1) (T-cell translocation protein 1) (LIM-only protein 1).

RBTN1_MOUSE
θ value	0.47712 (rank : 239)	NC score	0.281661 (rank : 164)
Query Neighborhood Hits	293	Target Neighborhood Hits	109	Shared Neighborhood Hits	93
SwissProt Accessions	Q924W9	Gene names	Lmo1, Rbtn1, Rhom1, Ttg1
Domain Architecture	No domain graphic available
Description	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM-only protein 1).

SRMS_MOUSE
θ value	0.47712 (rank : 240)	NC score	0.087126 (rank : 355)
Query Neighborhood Hits	293	Target Neighborhood Hits	964	Shared Neighborhood Hits	95
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

JIP1_HUMAN
θ value	0.62314 (rank : 241)	NC score	0.139351 (rank : 293)
Query Neighborhood Hits	293	Target Neighborhood Hits	271	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	0.62314 (rank : 242)	NC score	0.139714 (rank : 292)
Query Neighborhood Hits	293	Target Neighborhood Hits	259	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LHX3_HUMAN
θ value	0.62314 (rank : 243)	NC score	0.243163 (rank : 203)
Query Neighborhood Hits	293	Target Neighborhood Hits	474	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UBR4, Q9NZB5, Q9P0I8, Q9P0I9	Gene names	LHX3
Domain Architecture
Description	LIM/homeobox protein Lhx3.

NGEF_MOUSE
θ value	0.62314 (rank : 244)	NC score	0.191978 (rank : 241)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	82
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

P85B_MOUSE
θ value	0.62314 (rank : 245)	NC score	0.151295 (rank : 282)
Query Neighborhood Hits	293	Target Neighborhood Hits	519	Shared Neighborhood Hits	79
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PTK6_MOUSE
θ value	0.62314 (rank : 246)	NC score	0.102868 (rank : 329)
Query Neighborhood Hits	293	Target Neighborhood Hits	1026	Shared Neighborhood Hits	135
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ASPP1_HUMAN
θ value	0.813845 (rank : 247)	NC score	0.189535 (rank : 245)
Query Neighborhood Hits	293	Target Neighborhood Hits	956	Shared Neighborhood Hits	145
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BI2L1_MOUSE
θ value	0.813845 (rank : 248)	NC score	0.168819 (rank : 261)
Query Neighborhood Hits	293	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

LHX2_HUMAN
θ value	0.813845 (rank : 249)	NC score	0.252997 (rank : 194)
Query Neighborhood Hits	293	Target Neighborhood Hits	432	Shared Neighborhood Hits	98
SwissProt Accessions	P50458, O95860, Q8N1Z3	Gene names	LHX2, LH2
Domain Architecture
Description	LIM/homeobox protein Lhx2 (Homeobox protein LH-2).

LHX2_MOUSE
θ value	0.813845 (rank : 250)	NC score	0.252990 (rank : 195)
Query Neighborhood Hits	293	Target Neighborhood Hits	431	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z0S2	Gene names	Lhx2
Domain Architecture
Description	LIM/homeobox protein Lhx2.

LIMK2_MOUSE
θ value	0.813845 (rank : 251)	NC score	0.136805 (rank : 295)
Query Neighborhood Hits	293	Target Neighborhood Hits	998	Shared Neighborhood Hits	131
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RUSC2_MOUSE
θ value	0.813845 (rank : 252)	NC score	0.092756 (rank : 341)
Query Neighborhood Hits	293	Target Neighborhood Hits	305	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

BTK_HUMAN
θ value	1.06291 (rank : 253)	NC score	0.119272 (rank : 308)
Query Neighborhood Hits	293	Target Neighborhood Hits	1026	Shared Neighborhood Hits	151
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

IASPP_MOUSE
θ value	1.06291 (rank : 254)	NC score	0.192307 (rank : 239)
Query Neighborhood Hits	293	Target Neighborhood Hits	1024	Shared Neighborhood Hits	143
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

K1C14_HUMAN
θ value	1.06291 (rank : 255)	NC score	0.003164 (rank : 463)
Query Neighborhood Hits	293	Target Neighborhood Hits	491	Shared Neighborhood Hits	11
SwissProt Accessions	P02533, Q14715, Q53XY3, Q9BUE3, Q9UBN2, Q9UBN3, Q9UCY4	Gene names	KRT14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

K1C14_MOUSE
θ value	1.06291 (rank : 256)	NC score	0.003475 (rank : 462)
Query Neighborhood Hits	293	Target Neighborhood Hits	501	Shared Neighborhood Hits	13
SwissProt Accessions	Q61781, Q91VQ4	Gene names	Krt14, Krt1-14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

LIMK2_HUMAN
θ value	1.06291 (rank : 257)	NC score	0.131391 (rank : 297)
Query Neighborhood Hits	293	Target Neighborhood Hits	986	Shared Neighborhood Hits	130
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

NOXO1_MOUSE
θ value	1.06291 (rank : 258)	NC score	0.250449 (rank : 197)
Query Neighborhood Hits	293	Target Neighborhood Hits	114	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

VAV3_HUMAN
θ value	1.06291 (rank : 259)	NC score	0.295705 (rank : 155)
Query Neighborhood Hits	293	Target Neighborhood Hits	398	Shared Neighborhood Hits	152
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

AMPH_MOUSE
θ value	1.38821 (rank : 260)	NC score	0.191442 (rank : 243)
Query Neighborhood Hits	293	Target Neighborhood Hits	291	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

CF049_HUMAN
θ value	1.38821 (rank : 261)	NC score	0.321828 (rank : 135)
Query Neighborhood Hits	293	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	Q2TBC4, Q5T3D4, Q9NSV1	Gene names	C6orf49
Domain Architecture	No domain graphic available
Description	Protein C6orf49.

IASPP_HUMAN
θ value	1.38821 (rank : 262)	NC score	0.208435 (rank : 229)
Query Neighborhood Hits	293	Target Neighborhood Hits	688	Shared Neighborhood Hits	134
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

S3TC2_MOUSE
θ value	1.38821 (rank : 263)	NC score	0.066388 (rank : 400)
Query Neighborhood Hits	293	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

BCAR1_HUMAN
θ value	1.81305 (rank : 264)	NC score	0.264243 (rank : 182)
Query Neighborhood Hits	293	Target Neighborhood Hits	554	Shared Neighborhood Hits	148
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

LMO4_HUMAN
θ value	1.81305 (rank : 265)	NC score	0.288436 (rank : 162)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	95
SwissProt Accessions	P61968, O00158, O88894	Gene names	LMO4
Domain Architecture
Description	LIM domain transcription factor LMO4 (LIM domain only protein 4) (LMO- 4) (Breast tumor autoantigen).

LMO4_MOUSE
θ value	1.81305 (rank : 266)	NC score	0.288436 (rank : 163)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	95
SwissProt Accessions	P61969, O00158, O88894	Gene names	Lmo4
Domain Architecture
Description	LIM domain transcription factor LMO4 (LIM domain only protein 4) (LMO- 4) (Breast tumor autoantigen).

PDLI1_HUMAN
θ value	1.81305 (rank : 267)	NC score	0.204622 (rank : 230)
Query Neighborhood Hits	293	Target Neighborhood Hits	242	Shared Neighborhood Hits	77
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PTK6_HUMAN
θ value	1.81305 (rank : 268)	NC score	0.100352 (rank : 330)
Query Neighborhood Hits	293	Target Neighborhood Hits	1020	Shared Neighborhood Hits	138
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

STAC_MOUSE
θ value	1.81305 (rank : 269)	NC score	0.359069 (rank : 111)
Query Neighborhood Hits	293	Target Neighborhood Hits	268	Shared Neighborhood Hits	144
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VPS72_MOUSE
θ value	1.81305 (rank : 270)	NC score	0.020088 (rank : 455)
Query Neighborhood Hits	293	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

COBA2_MOUSE
θ value	2.36792 (rank : 271)	NC score	0.003089 (rank : 464)
Query Neighborhood Hits	293	Target Neighborhood Hits	501	Shared Neighborhood Hits	9
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

LYN_HUMAN
θ value	2.36792 (rank : 272)	NC score	0.114077 (rank : 314)
Query Neighborhood Hits	293	Target Neighborhood Hits	1022	Shared Neighborhood Hits	135
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

P85B_HUMAN
θ value	2.36792 (rank : 273)	NC score	0.152691 (rank : 279)
Query Neighborhood Hits	293	Target Neighborhood Hits	543	Shared Neighborhood Hits	80
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

STAC_HUMAN
θ value	2.36792 (rank : 274)	NC score	0.366562 (rank : 103)
Query Neighborhood Hits	293	Target Neighborhood Hits	276	Shared Neighborhood Hits	145
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BCAR1_MOUSE
θ value	3.0926 (rank : 275)	NC score	0.263020 (rank : 183)
Query Neighborhood Hits	293	Target Neighborhood Hits	438	Shared Neighborhood Hits	146
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BLK_HUMAN
θ value	3.0926 (rank : 276)	NC score	0.108913 (rank : 318)
Query Neighborhood Hits	293	Target Neighborhood Hits	994	Shared Neighborhood Hits	128
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CACB2_MOUSE
θ value	3.0926 (rank : 277)	NC score	0.009050 (rank : 459)
Query Neighborhood Hits	293	Target Neighborhood Hits	94	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

FNBP2_HUMAN
θ value	3.0926 (rank : 278)	NC score	0.164699 (rank : 265)
Query Neighborhood Hits	293	Target Neighborhood Hits	432	Shared Neighborhood Hits	127
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

NOXO1_HUMAN
θ value	3.0926 (rank : 279)	NC score	0.182506 (rank : 252)
Query Neighborhood Hits	293	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PDLI1_MOUSE
θ value	3.0926 (rank : 280)	NC score	0.188043 (rank : 248)
Query Neighborhood Hits	293	Target Neighborhood Hits	213	Shared Neighborhood Hits	68
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

VPS72_HUMAN
θ value	3.0926 (rank : 281)	NC score	0.019244 (rank : 457)
Query Neighborhood Hits	293	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

UACA_HUMAN
θ value	4.03905 (rank : 282)	NC score	0.008096 (rank : 460)
Query Neighborhood Hits	293	Target Neighborhood Hits	1622	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

BLK_MOUSE
θ value	5.27518 (rank : 283)	NC score	0.105651 (rank : 324)
Query Neighborhood Hits	293	Target Neighborhood Hits	992	Shared Neighborhood Hits	116
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FUT8_MOUSE
θ value	5.27518 (rank : 284)	NC score	0.075754 (rank : 378)
Query Neighborhood Hits	293	Target Neighborhood Hits	115	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

LYN_MOUSE
θ value	5.27518 (rank : 285)	NC score	0.114071 (rank : 315)
Query Neighborhood Hits	293	Target Neighborhood Hits	1023	Shared Neighborhood Hits	136
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MILK1_HUMAN
θ value	5.27518 (rank : 286)	NC score	0.140792 (rank : 291)
Query Neighborhood Hits	293	Target Neighborhood Hits	427	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

KPCA_HUMAN
θ value	6.88961 (rank : 287)	NC score	0.024199 (rank : 454)
Query Neighborhood Hits	293	Target Neighborhood Hits	1070	Shared Neighborhood Hits	49
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SPTA2_HUMAN
θ value	6.88961 (rank : 288)	NC score	0.164120 (rank : 266)
Query Neighborhood Hits	293	Target Neighborhood Hits	888	Shared Neighborhood Hits	153
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAC3_HUMAN
θ value	6.88961 (rank : 289)	NC score	0.320382 (rank : 138)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	131
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	6.88961 (rank : 290)	NC score	0.321376 (rank : 136)
Query Neighborhood Hits	293	Target Neighborhood Hits	232	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

TXK_MOUSE
θ value	6.88961 (rank : 291)	NC score	0.098875 (rank : 333)
Query Neighborhood Hits	293	Target Neighborhood Hits	980	Shared Neighborhood Hits	122
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CJ006_MOUSE
θ value	8.99809 (rank : 292)	NC score	0.006275 (rank : 461)
Query Neighborhood Hits	293	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

DLG5_HUMAN
θ value	8.99809 (rank : 293)	NC score	0.019920 (rank : 456)
Query Neighborhood Hits	293	Target Neighborhood Hits	1088	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ABL1_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.089876 (rank : 348)
Query Neighborhood Hits	293	Target Neighborhood Hits	1220	Shared Neighborhood Hits	118
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.090914 (rank : 346)
Query Neighborhood Hits	293	Target Neighborhood Hits	1178	Shared Neighborhood Hits	115
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.086492 (rank : 357)
Query Neighborhood Hits	293	Target Neighborhood Hits	1045	Shared Neighborhood Hits	104
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.054816 (rank : 437)
Query Neighborhood Hits	293	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.056080 (rank : 432)
Query Neighborhood Hits	293	Target Neighborhood Hits	1080	Shared Neighborhood Hits	75
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

APS_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.078575 (rank : 375)
Query Neighborhood Hits	293	Target Neighborhood Hits	162	Shared Neighborhood Hits	43
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.055994 (rank : 433)
Query Neighborhood Hits	293	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.070700 (rank : 386)
Query Neighborhood Hits	293	Target Neighborhood Hits	176	Shared Neighborhood Hits	20
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.066008 (rank : 403)
Query Neighborhood Hits	293	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.060617 (rank : 414)
Query Neighborhood Hits	293	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.059134 (rank : 419)
Query Neighborhood Hits	293	Target Neighborhood Hits	120	Shared Neighborhood Hits	23
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.091648 (rank : 343)
Query Neighborhood Hits	293	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.091343 (rank : 345)
Query Neighborhood Hits	293	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.179810 (rank : 253)
Query Neighborhood Hits	293	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG8_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.086123 (rank : 359)
Query Neighborhood Hits	293	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.092082 (rank : 342)
Query Neighborhood Hits	293	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.220633 (rank : 219)
Query Neighborhood Hits	293	Target Neighborhood Hits	235	Shared Neighborhood Hits	134
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.220672 (rank : 218)
Query Neighborhood Hits	293	Target Neighborhood Hits	234	Shared Neighborhood Hits	131
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.066800 (rank : 397)
Query Neighborhood Hits	293	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.069050 (rank : 394)
Query Neighborhood Hits	293	Target Neighborhood Hits	125	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.075612 (rank : 379)
Query Neighborhood Hits	293	Target Neighborhood Hits	375	Shared Neighborhood Hits	36
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.069166 (rank : 393)
Query Neighborhood Hits	293	Target Neighborhood Hits	351	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.069246 (rank : 392)
Query Neighborhood Hits	293	Target Neighborhood Hits	344	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.093411 (rank : 339)
Query Neighborhood Hits	293	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASPP2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.130830 (rank : 299)
Query Neighborhood Hits	293	Target Neighborhood Hits	1156	Shared Neighborhood Hits	122
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCAR3_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.052121 (rank : 441)
Query Neighborhood Hits	293	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.051281 (rank : 448)
Query Neighborhood Hits	293	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BMX_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.058572 (rank : 422)
Query Neighborhood Hits	293	Target Neighborhood Hits	942	Shared Neighborhood Hits	53
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.058661 (rank : 421)
Query Neighborhood Hits	293	Target Neighborhood Hits	912	Shared Neighborhood Hits	53
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BTK_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.112611 (rank : 316)
Query Neighborhood Hits	293	Target Neighborhood Hits	1017	Shared Neighborhood Hits	145
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CASL_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.217749 (rank : 221)
Query Neighborhood Hits	293	Target Neighborhood Hits	259	Shared Neighborhood Hits	121
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.222918 (rank : 216)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	125
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CIP4_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.129077 (rank : 301)
Query Neighborhood Hits	293	Target Neighborhood Hits	374	Shared Neighborhood Hits	61
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CT032_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.272174 (rank : 173)
Query Neighborhood Hits	293	Target Neighborhood Hits	235	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.106423 (rank : 321)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.107653 (rank : 319)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DEMA_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.096438 (rank : 335)
Query Neighborhood Hits	293	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q08495, Q13215, Q9BRE3	Gene names	EPB49, DMT
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

DEMA_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.095470 (rank : 336)
Query Neighborhood Hits	293	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WV69	Gene names	Epb49, Epb4.9
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

DREB_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.050594 (rank : 450)
Query Neighborhood Hits	293	Target Neighborhood Hits	450	Shared Neighborhood Hits	15
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DREB_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.051391 (rank : 446)
Query Neighborhood Hits	293	Target Neighborhood Hits	446	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ECT2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.072457 (rank : 384)
Query Neighborhood Hits	293	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.074722 (rank : 381)
Query Neighborhood Hits	293	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.066176 (rank : 401)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	76
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.063330 (rank : 407)
Query Neighborhood Hits	293	Target Neighborhood Hits	221	Shared Neighborhood Hits	74
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EPS8_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.116210 (rank : 311)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	89
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.119631 (rank : 307)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	103
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.115488 (rank : 313)
Query Neighborhood Hits	293	Target Neighborhood Hits	162	Shared Neighborhood Hits	87
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.105537 (rank : 325)
Query Neighborhood Hits	293	Target Neighborhood Hits	143	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.146271 (rank : 289)
Query Neighborhood Hits	293	Target Neighborhood Hits	193	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.141399 (rank : 290)
Query Neighborhood Hits	293	Target Neighborhood Hits	169	Shared Neighborhood Hits	106
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.169811 (rank : 260)
Query Neighborhood Hits	293	Target Neighborhood Hits	206	Shared Neighborhood Hits	108
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FER_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.060837 (rank : 412)
Query Neighborhood Hits	293	Target Neighborhood Hits	1278	Shared Neighborhood Hits	68
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGD1_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.051292 (rank : 447)
Query Neighborhood Hits	293	Target Neighborhood Hits	367	Shared Neighborhood Hits	32
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.057486 (rank : 427)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.053948 (rank : 438)
Query Neighborhood Hits	293	Target Neighborhood Hits	163	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.054849 (rank : 436)
Query Neighborhood Hits	293	Target Neighborhood Hits	249	Shared Neighborhood Hits	22
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.057898 (rank : 425)
Query Neighborhood Hits	293	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.060484 (rank : 415)
Query Neighborhood Hits	293	Target Neighborhood Hits	219	Shared Neighborhood Hits	24
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.061563 (rank : 409)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FUT8_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.074777 (rank : 380)
Query Neighborhood Hits	293	Target Neighborhood Hits	67	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GAS7_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.053475 (rank : 439)
Query Neighborhood Hits	293	Target Neighborhood Hits	258	Shared Neighborhood Hits	13
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GNRP_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.058536 (rank : 423)
Query Neighborhood Hits	293	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.060723 (rank : 413)
Query Neighborhood Hits	293	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.062874 (rank : 408)
Query Neighborhood Hits	293	Target Neighborhood Hits	147	Shared Neighborhood Hits	42
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.064527 (rank : 404)
Query Neighborhood Hits	293	Target Neighborhood Hits	156	Shared Neighborhood Hits	44
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.082422 (rank : 368)
Query Neighborhood Hits	293	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.083819 (rank : 364)
Query Neighborhood Hits	293	Target Neighborhood Hits	149	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.066164 (rank : 402)
Query Neighborhood Hits	293	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.073504 (rank : 383)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.054970 (rank : 435)
Query Neighborhood Hits	293	Target Neighborhood Hits	350	Shared Neighborhood Hits	27
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HSH2D_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.079539 (rank : 373)
Query Neighborhood Hits	293	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.051268 (rank : 449)
Query Neighborhood Hits	293	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.050517 (rank : 451)
Query Neighborhood Hits	293	Target Neighborhood Hits	848	Shared Neighborhood Hits	41
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.051494 (rank : 445)
Query Neighborhood Hits	293	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ISL1_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.229785 (rank : 211)
Query Neighborhood Hits	293	Target Neighborhood Hits	421	Shared Neighborhood Hits	93
SwissProt Accessions	P61371, P20663, P47894	Gene names	ISL1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

ISL1_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.229785 (rank : 212)
Query Neighborhood Hits	293	Target Neighborhood Hits	421	Shared Neighborhood Hits	93
SwissProt Accessions	P61372, P20663, P47894, Q812D8	Gene names	Isl1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

ISL2_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.233782 (rank : 206)
Query Neighborhood Hits	293	Target Neighborhood Hits	435	Shared Neighborhood Hits	96
SwissProt Accessions	Q96A47	Gene names	ISL2
Domain Architecture
Description	Insulin gene enhancer protein ISL-2 (Islet-2).

ISL2_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.233422 (rank : 207)
Query Neighborhood Hits	293	Target Neighborhood Hits	426	Shared Neighborhood Hits	96
SwissProt Accessions	Q9CXV0	Gene names	Isl2
Domain Architecture
Description	Insulin gene enhancer protein ISL-2 (Islet-2).

ITK_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.086796 (rank : 356)
Query Neighborhood Hits	293	Target Neighborhood Hits	1016	Shared Neighborhood Hits	118
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.083061 (rank : 367)
Query Neighborhood Hits	293	Target Neighborhood Hits	985	Shared Neighborhood Hits	105
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.057046 (rank : 428)
Query Neighborhood Hits	293	Target Neighborhood Hits	901	Shared Neighborhood Hits	57
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.057795 (rank : 426)
Query Neighborhood Hits	293	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.061314 (rank : 410)
Query Neighborhood Hits	293	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.099522 (rank : 331)
Query Neighborhood Hits	293	Target Neighborhood Hits	987	Shared Neighborhood Hits	111
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.098609 (rank : 334)
Query Neighborhood Hits	293	Target Neighborhood Hits	981	Shared Neighborhood Hits	110
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.058690 (rank : 420)
Query Neighborhood Hits	293	Target Neighborhood Hits	531	Shared Neighborhood Hits	48
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.066616 (rank : 399)
Query Neighborhood Hits	293	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LMO7_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.081791 (rank : 371)
Query Neighborhood Hits	293	Target Neighborhood Hits	507	Shared Neighborhood Hits	70
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LMX1B_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.240614 (rank : 205)
Query Neighborhood Hits	293	Target Neighborhood Hits	404	Shared Neighborhood Hits	93
SwissProt Accessions	O60663, O75463	Gene names	LMX1B
Domain Architecture
Description	LIM homeobox transcription factor 1 beta (LIM/homeobox protein LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2).

LMX1B_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.240904 (rank : 204)
Query Neighborhood Hits	293	Target Neighborhood Hits	394	Shared Neighborhood Hits	93
SwissProt Accessions	O88609	Gene names	Lmx1b
Domain Architecture
Description	LIM homeobox transcription factor 1 beta (LIM/homeobox protein LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2).

LNK_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.070147 (rank : 388)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.069364 (rank : 390)
Query Neighborhood Hits	293	Target Neighborhood Hits	132	Shared Neighborhood Hits	42
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.069921 (rank : 389)
Query Neighborhood Hits	293	Target Neighborhood Hits	954	Shared Neighborhood Hits	70
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.071476 (rank : 385)
Query Neighborhood Hits	293	Target Neighborhood Hits	952	Shared Neighborhood Hits	74
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.085810 (rank : 360)
Query Neighborhood Hits	293	Target Neighborhood Hits	255	Shared Neighborhood Hits	44
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.068176 (rank : 395)
Query Neighborhood Hits	293	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MPP6_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.051903 (rank : 442)
Query Neighborhood Hits	293	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.050155 (rank : 453)
Query Neighborhood Hits	293	Target Neighborhood Hits	187	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NPHP1_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.274275 (rank : 170)
Query Neighborhood Hits	293	Target Neighborhood Hits	288	Shared Neighborhood Hits	127
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

P55G_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.120353 (rank : 306)
Query Neighborhood Hits	293	Target Neighborhood Hits	451	Shared Neighborhood Hits	60
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.117144 (rank : 310)
Query Neighborhood Hits	293	Target Neighborhood Hits	401	Shared Neighborhood Hits	54
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PDLI2_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.148692 (rank : 283)
Query Neighborhood Hits	293	Target Neighborhood Hits	245	Shared Neighborhood Hits	68
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.147370 (rank : 285)
Query Neighborhood Hits	293	Target Neighborhood Hits	220	Shared Neighborhood Hits	69
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PKHG1_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.093988 (rank : 337)
Query Neighborhood Hits	293	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PPIP2_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.116124 (rank : 312)
Query Neighborhood Hits	293	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.104214 (rank : 328)
Query Neighborhood Hits	293	Target Neighborhood Hits	308	Shared Neighborhood Hits	17
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.086127 (rank : 358)
Query Neighborhood Hits	293	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTN11_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.060223 (rank : 417)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.060233 (rank : 416)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.051902 (rank : 443)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RBTN2_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.273941 (rank : 172)
Query Neighborhood Hits	293	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P25791, Q9HD58	Gene names	LMO2, RBTN2, RHOM2, TTG2
Domain Architecture
Description	Rhombotin-2 (Cysteine-rich protein TTG-2) (T-cell translocation protein 2) (LIM-only protein 2).

RBTN2_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.273950 (rank : 171)
Query Neighborhood Hits	293	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P25801	Gene names	Lmo2, Rbtn-2, Rbtn2, Rhom-2
Domain Architecture
Description	Rhombotin-2 (Cysteine-rich protein TTG-2) (T-cell translocation protein 2) (LIM-only protein 2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.056186 (rank : 431)
Query Neighborhood Hits	293	Target Neighborhood Hits	641	Shared Neighborhood Hits	31
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG04_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.188522 (rank : 247)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.106448 (rank : 320)
Query Neighborhood Hits	293	Target Neighborhood Hits	1479	Shared Neighborhood Hits	119
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.104391 (rank : 327)
Query Neighborhood Hits	293	Target Neighborhood Hits	1376	Shared Neighborhood Hits	132
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.203719 (rank : 231)
Query Neighborhood Hits	293	Target Neighborhood Hits	263	Shared Neighborhood Hits	101
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.196416 (rank : 237)
Query Neighborhood Hits	293	Target Neighborhood Hits	246	Shared Neighborhood Hits	91
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC2_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.090790 (rank : 347)
Query Neighborhood Hits	293	Target Neighborhood Hits	205	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH21A_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.070197 (rank : 387)
Query Neighborhood Hits	293	Target Neighborhood Hits	89	Shared Neighborhood Hits	29
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.066783 (rank : 398)
Query Neighborhood Hits	293	Target Neighborhood Hits	89	Shared Neighborhood Hits	29
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.087177 (rank : 354)
Query Neighborhood Hits	293	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.099014 (rank : 332)
Query Neighborhood Hits	293	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.061032 (rank : 411)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.064270 (rank : 406)
Query Neighborhood Hits	293	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.064526 (rank : 405)
Query Neighborhood Hits	293	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH2D3_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.053452 (rank : 440)
Query Neighborhood Hits	293	Target Neighborhood Hits	188	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.056234 (rank : 430)
Query Neighborhood Hits	293	Target Neighborhood Hits	174	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN1_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.105455 (rank : 326)
Query Neighborhood Hits	293	Target Neighborhood Hits	1041	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.131328 (rank : 298)
Query Neighborhood Hits	293	Target Neighborhood Hits	446	Shared Neighborhood Hits	100
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.088060 (rank : 353)
Query Neighborhood Hits	293	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.089051 (rank : 350)
Query Neighborhood Hits	293	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.083439 (rank : 365)
Query Neighborhood Hits	293	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.088985 (rank : 351)
Query Neighborhood Hits	293	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.079574 (rank : 372)
Query Neighborhood Hits	293	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.078620 (rank : 374)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.082044 (rank : 369)
Query Neighborhood Hits	293	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.084954 (rank : 361)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.077310 (rank : 377)
Query Neighborhood Hits	293	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.081888 (rank : 370)
Query Neighborhood Hits	293	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.083230 (rank : 366)
Query Neighborhood Hits	293	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.084123 (rank : 363)
Query Neighborhood Hits	293	Target Neighborhood Hits	169	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.152318 (rank : 280)
Query Neighborhood Hits	293	Target Neighborhood Hits	113	Shared Neighborhood Hits	45
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.151681 (rank : 281)
Query Neighborhood Hits	293	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.159604 (rank : 268)
Query Neighborhood Hits	293	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.159539 (rank : 269)
Query Neighborhood Hits	293	Target Neighborhood Hits	136	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.077741 (rank : 376)
Query Neighborhood Hits	293	Target Neighborhood Hits	81	Shared Neighborhood Hits	49
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.093196 (rank : 340)
Query Neighborhood Hits	293	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX9_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.185331 (rank : 251)
Query Neighborhood Hits	293	Target Neighborhood Hits	148	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.166110 (rank : 263)
Query Neighborhood Hits	293	Target Neighborhood Hits	141	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOCS2_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.051874 (rank : 444)
Query Neighborhood Hits	293	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.056668 (rank : 429)
Query Neighborhood Hits	293	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.055763 (rank : 434)
Query Neighborhood Hits	293	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.067461 (rank : 396)
Query Neighborhood Hits	293	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SRGP1_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.155789 (rank : 274)
Query Neighborhood Hits	293	Target Neighborhood Hits	390	Shared Neighborhood Hits	122
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.168363 (rank : 262)
Query Neighborhood Hits	293	Target Neighborhood Hits	331	Shared Neighborhood Hits	131
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.170324 (rank : 259)
Query Neighborhood Hits	293	Target Neighborhood Hits	324	Shared Neighborhood Hits	132
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.073769 (rank : 382)
Query Neighborhood Hits	293	Target Neighborhood Hits	946	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

STAM2_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.370515 (rank : 97)
Query Neighborhood Hits	293	Target Neighborhood Hits	288	Shared Neighborhood Hits	147
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.380826 (rank : 89)
Query Neighborhood Hits	293	Target Neighborhood Hits	285	Shared Neighborhood Hits	148
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.112271 (rank : 317)
Query Neighborhood Hits	293	Target Neighborhood Hits	872	Shared Neighborhood Hits	120
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.122541 (rank : 304)
Query Neighborhood Hits	293	Target Neighborhood Hits	409	Shared Neighborhood Hits	109
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.093674 (rank : 338)
Query Neighborhood Hits	293	Target Neighborhood Hits	1006	Shared Neighborhood Hits	123
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.091551 (rank : 344)
Query Neighborhood Hits	293	Target Neighborhood Hits	1006	Shared Neighborhood Hits	121
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.084788 (rank : 362)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	24
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.088722 (rank : 352)
Query Neighborhood Hits	293	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TXK_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.089558 (rank : 349)
Query Neighborhood Hits	293	Target Neighborhood Hits	971	Shared Neighborhood Hits	109
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ZAP70_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.058170 (rank : 424)
Query Neighborhood Hits	293	Target Neighborhood Hits	893	Shared Neighborhood Hits	57
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.059143 (rank : 418)
Query Neighborhood Hits	293	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZN185_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.069341 (rank : 391)
Query Neighborhood Hits	293	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

ZN185_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.050466 (rank : 452)
Query Neighborhood Hits	293	Target Neighborhood Hits	89	Shared Neighborhood Hits	33
SwissProt Accessions	Q62394	Gene names	Znf185, Zfp185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein Zfp185) (P1-A).

Hits sorted by NC score

LASP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	7.59556e-124 (rank : 2)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	293
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.996858 (rank : 2)	θ value	7.8238e-137 (rank : 1)
Query Neighborhood Hits	293	Target Neighborhood Hits	297	Shared Neighborhood Hits	285
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NEBL_HUMAN
NC score	0.644977 (rank : 3)	θ value	3.28125e-26 (rank : 3)
Query Neighborhood Hits	293	Target Neighborhood Hits	457	Shared Neighborhood Hits	171
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
NC score	0.633578 (rank : 4)	θ value	2.87452e-22 (rank : 6)
Query Neighborhood Hits	293	Target Neighborhood Hits	420	Shared Neighborhood Hits	160
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

VINEX_HUMAN
NC score	0.569562 (rank : 5)	θ value	1.38499e-08 (rank : 11)
Query Neighborhood Hits	293	Target Neighborhood Hits	270	Shared Neighborhood Hits	167
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SRC8_HUMAN
NC score	0.569376 (rank : 6)	θ value	5.62301e-10 (rank : 8)
Query Neighborhood Hits	293	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.567835 (rank : 7)	θ value	2.52405e-10 (rank : 7)
Query Neighborhood Hits	293	Target Neighborhood Hits	292	Shared Neighborhood Hits	152
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

VINEX_MOUSE
NC score	0.563990 (rank : 8)	θ value	3.08544e-08 (rank : 14)
Query Neighborhood Hits	293	Target Neighborhood Hits	286	Shared Neighborhood Hits	173
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NRAP_HUMAN
NC score	0.554280 (rank : 9)	θ value	9.87957e-23 (rank : 4)
Query Neighborhood Hits	293	Target Neighborhood Hits	159	Shared Neighborhood Hits	105
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
NC score	0.554213 (rank : 10)	θ value	9.87957e-23 (rank : 5)
Query Neighborhood Hits	293	Target Neighborhood Hits	167	Shared Neighborhood Hits	101
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

SRBS1_HUMAN
NC score	0.547209 (rank : 11)	θ value	5.26297e-08 (rank : 15)
Query Neighborhood Hits	293	Target Neighborhood Hits	396	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ABI2_MOUSE
NC score	0.543319 (rank : 12)	θ value	8.97725e-08 (rank : 18)
Query Neighborhood Hits	293	Target Neighborhood Hits	266	Shared Neighborhood Hits	154
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HCLS1_MOUSE
NC score	0.541444 (rank : 13)	θ value	1.29631e-06 (rank : 32)
Query Neighborhood Hits	293	Target Neighborhood Hits	329	Shared Neighborhood Hits	147
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRBS1_MOUSE
NC score	0.541152 (rank : 14)	θ value	5.26297e-08 (rank : 16)
Query Neighborhood Hits	293	Target Neighborhood Hits	409	Shared Neighborhood Hits	168
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ABI2_HUMAN
NC score	0.538197 (rank : 15)	θ value	8.97725e-08 (rank : 17)
Query Neighborhood Hits	293	Target Neighborhood Hits	350	Shared Neighborhood Hits	156
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

HCLS1_HUMAN
NC score	0.535480 (rank : 16)	θ value	1.09739e-05 (rank : 40)
Query Neighborhood Hits	293	Target Neighborhood Hits	358	Shared Neighborhood Hits	148
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI1_MOUSE
NC score	0.534366 (rank : 17)	θ value	4.45536e-07 (rank : 25)
Query Neighborhood Hits	293	Target Neighborhood Hits	246	Shared Neighborhood Hits	149
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CRIP1_HUMAN
NC score	0.526128 (rank : 18)	θ value	1.38499e-08 (rank : 10)
Query Neighborhood Hits	293	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P50238, Q13628, Q96J34	Gene names	CRIP1, CRIP
Domain Architecture
Description	Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP) (Cysteine-rich heart protein) (hCRHP).

CRIP1_MOUSE
NC score	0.524876 (rank : 19)	θ value	1.80886e-08 (rank : 12)
Query Neighborhood Hits	293	Target Neighborhood Hits	118	Shared Neighborhood Hits	98
SwissProt Accessions	P63254, P04006, Q3THF0	Gene names	Crip1, Crip
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP).

DBNL_HUMAN
NC score	0.521081 (rank : 20)	θ value	4.76016e-09 (rank : 9)
Query Neighborhood Hits	293	Target Neighborhood Hits	244	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PACN2_MOUSE
NC score	0.520775 (rank : 21)	θ value	1.53129e-07 (rank : 24)
Query Neighborhood Hits	293	Target Neighborhood Hits	382	Shared Neighborhood Hits	160
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABI1_HUMAN
NC score	0.520504 (rank : 22)	θ value	7.59969e-07 (rank : 27)
Query Neighborhood Hits	293	Target Neighborhood Hits	257	Shared Neighborhood Hits	149
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PACN2_HUMAN
NC score	0.518251 (rank : 23)	θ value	1.53129e-07 (rank : 23)
Query Neighborhood Hits	293	Target Neighborhood Hits	339	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.518241 (rank : 24)	θ value	1.17247e-07 (rank : 20)
Query Neighborhood Hits	293	Target Neighborhood Hits	283	Shared Neighborhood Hits	156
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.515183 (rank : 25)	θ value	1.17247e-07 (rank : 19)
Query Neighborhood Hits	293	Target Neighborhood Hits	320	Shared Neighborhood Hits	156
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

DBNL_MOUSE
NC score	0.514473 (rank : 26)	θ value	1.80886e-08 (rank : 13)
Query Neighborhood Hits	293	Target Neighborhood Hits	306	Shared Neighborhood Hits	137
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SH3G3_MOUSE
NC score	0.513224 (rank : 27)	θ value	8.40245e-06 (rank : 39)
Query Neighborhood Hits	293	Target Neighborhood Hits	236	Shared Neighborhood Hits	151
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PPIP1_MOUSE
NC score	0.501740 (rank : 28)	θ value	9.92553e-07 (rank : 29)
Query Neighborhood Hits	293	Target Neighborhood Hits	377	Shared Neighborhood Hits	172
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PACN3_MOUSE
NC score	0.501532 (rank : 29)	θ value	7.59969e-07 (rank : 28)
Query Neighborhood Hits	293	Target Neighborhood Hits	380	Shared Neighborhood Hits	152
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SH3G2_HUMAN
NC score	0.501363 (rank : 30)	θ value	1.43324e-05 (rank : 45)
Query Neighborhood Hits	293	Target Neighborhood Hits	324	Shared Neighborhood Hits	153
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CD2AP_MOUSE
NC score	0.500799 (rank : 31)	θ value	0.000602161 (rank : 85)
Query Neighborhood Hits	293	Target Neighborhood Hits	336	Shared Neighborhood Hits	165
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3G3_HUMAN
NC score	0.499424 (rank : 32)	θ value	1.09739e-05 (rank : 41)
Query Neighborhood Hits	293	Target Neighborhood Hits	222	Shared Neighborhood Hits	149
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

PACN3_HUMAN
NC score	0.498084 (rank : 33)	θ value	1.29631e-06 (rank : 33)
Query Neighborhood Hits	293	Target Neighborhood Hits	385	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PPIP1_HUMAN
NC score	0.495577 (rank : 34)	θ value	4.45536e-07 (rank : 26)
Query Neighborhood Hits	293	Target Neighborhood Hits	389	Shared Neighborhood Hits	172
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CD2AP_HUMAN
NC score	0.494785 (rank : 35)	θ value	0.000602161 (rank : 84)
Query Neighborhood Hits	293	Target Neighborhood Hits	315	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3G2_MOUSE
NC score	0.493683 (rank : 36)	θ value	2.44474e-05 (rank : 48)
Query Neighborhood Hits	293	Target Neighborhood Hits	319	Shared Neighborhood Hits	149
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3K1_HUMAN
NC score	0.491861 (rank : 37)	θ value	0.00175202 (rank : 101)
Query Neighborhood Hits	293	Target Neighborhood Hits	341	Shared Neighborhood Hits	160
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.490890 (rank : 38)	θ value	0.00175202 (rank : 102)
Query Neighborhood Hits	293	Target Neighborhood Hits	332	Shared Neighborhood Hits	162
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3G1_HUMAN
NC score	0.483522 (rank : 39)	θ value	5.44631e-05 (rank : 59)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	152
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NCF2_HUMAN
NC score	0.483487 (rank : 40)	θ value	0.00509761 (rank : 134)
Query Neighborhood Hits	293	Target Neighborhood Hits	229	Shared Neighborhood Hits	151
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CSRP3_HUMAN
NC score	0.482938 (rank : 41)	θ value	1.29631e-06 (rank : 30)
Query Neighborhood Hits	293	Target Neighborhood Hits	150	Shared Neighborhood Hits	106
SwissProt Accessions	P50461, Q9P131	Gene names	CSRP3, CLP, MLP
Domain Architecture
Description	Cysteine and glycine-rich protein 3 (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein).

CSRP1_HUMAN
NC score	0.482558 (rank : 42)	θ value	1.87187e-05 (rank : 46)
Query Neighborhood Hits	293	Target Neighborhood Hits	128	Shared Neighborhood Hits	106
SwissProt Accessions	P21291	Gene names	CSRP1, CSRP, CYRP
Domain Architecture
Description	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP1) (CRP).

CSRP3_MOUSE
NC score	0.482336 (rank : 43)	θ value	1.29631e-06 (rank : 31)
Query Neighborhood Hits	293	Target Neighborhood Hits	146	Shared Neighborhood Hits	106
SwissProt Accessions	P50462	Gene names	Csrp3, Clp, Mlp
Domain Architecture
Description	Cysteine and glycine-rich protein 3 (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein).

CSRP2_MOUSE
NC score	0.482212 (rank : 44)	θ value	1.43324e-05 (rank : 44)
Query Neighborhood Hits	293	Target Neighborhood Hits	152	Shared Neighborhood Hits	107
SwissProt Accessions	P97314, Q9CZG5	Gene names	Csrp2, Dlp1
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Double LIM protein 1) (DLP-1).

CSRP2_HUMAN
NC score	0.481703 (rank : 45)	θ value	1.43324e-05 (rank : 43)
Query Neighborhood Hits	293	Target Neighborhood Hits	150	Shared Neighborhood Hits	107
SwissProt Accessions	Q16527, Q93030	Gene names	CSRP2, LMO5, SMLIM
Domain Architecture
Description	Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Smooth muscle cell LIM protein) (SmLIM) (LIM-only protein 5).

CSRP1_MOUSE
NC score	0.481441 (rank : 46)	θ value	4.1701e-05 (rank : 49)
Query Neighborhood Hits	293	Target Neighborhood Hits	132	Shared Neighborhood Hits	106
SwissProt Accessions	P97315	Gene names	Csrp1, Crp1, Csrp
Domain Architecture
Description	Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP1) (CRP).

SH3G1_MOUSE
NC score	0.475486 (rank : 47)	θ value	0.00035302 (rank : 79)
Query Neighborhood Hits	293	Target Neighborhood Hits	291	Shared Neighborhood Hits	149
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CRIP2_HUMAN
NC score	0.473489 (rank : 48)	θ value	1.53129e-07 (rank : 21)
Query Neighborhood Hits	293	Target Neighborhood Hits	113	Shared Neighborhood Hits	90
SwissProt Accessions	P52943	Gene names	CRIP2, CRP2
Domain Architecture
Description	Cysteine-rich protein 2 (CRP2) (Protein ESP1).

CRIP2_MOUSE
NC score	0.470826 (rank : 49)	θ value	1.53129e-07 (rank : 22)
Query Neighborhood Hits	293	Target Neighborhood Hits	98	Shared Neighborhood Hits	89
SwissProt Accessions	Q9DCT8	Gene names	Crip2, Crp2, Hlp
Domain Architecture
Description	Cysteine-rich protein 2 (CRP2) (Heart LIM protein).

CRIP3_HUMAN
NC score	0.463987 (rank : 50)	θ value	1.43324e-05 (rank : 42)
Query Neighborhood Hits	293	Target Neighborhood Hits	104	Shared Neighborhood Hits	90
SwissProt Accessions	Q6Q6R5, Q5T043, Q6Q6R4, Q6Q6R6, Q6Q6R7	Gene names	CRIP3
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 3 (CRP3) (Chromosome 6 LIM-only protein) (h6LIMo).

LIMD2_HUMAN
NC score	0.463758 (rank : 51)	θ value	6.43352e-06 (rank : 37)
Query Neighborhood Hits	293	Target Neighborhood Hits	106	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BT23, Q96S91	Gene names	LIMD2
Domain Architecture	No domain graphic available
Description	LIM domain-containing protein 2.

LIMD2_MOUSE
NC score	0.462569 (rank : 52)	θ value	6.43352e-06 (rank : 38)
Query Neighborhood Hits	293	Target Neighborhood Hits	107	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BGB5	Gene names	Limd2
Domain Architecture	No domain graphic available
Description	LIM domain-containing protein 2.

ABI3_MOUSE
NC score	0.462451 (rank : 53)	θ value	0.00665767 (rank : 143)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_HUMAN
NC score	0.460301 (rank : 54)	θ value	0.00869519 (rank : 153)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	126
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NCF4_MOUSE
NC score	0.457807 (rank : 55)	θ value	0.0113563 (rank : 166)
Query Neighborhood Hits	293	Target Neighborhood Hits	177	Shared Neighborhood Hits	132
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CRIP3_MOUSE
NC score	0.441064 (rank : 56)	θ value	6.43352e-06 (rank : 35)
Query Neighborhood Hits	293	Target Neighborhood Hits	94	Shared Neighborhood Hits	81
SwissProt Accessions	Q6Q6R3, Q91V23, Q91V60	Gene names	Crip3, Tlp
Domain Architecture	No domain graphic available
Description	Cysteine-rich protein 3 (CRP3) (Thymus LIM protein) (m17TLP).

GRAP2_MOUSE
NC score	0.439228 (rank : 57)	θ value	0.00175202 (rank : 97)
Query Neighborhood Hits	293	Target Neighborhood Hits	297	Shared Neighborhood Hits	161
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCF4_HUMAN
NC score	0.429327 (rank : 58)	θ value	0.0113563 (rank : 165)
Query Neighborhood Hits	293	Target Neighborhood Hits	161	Shared Neighborhood Hits	122
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRB2_HUMAN
NC score	0.428818 (rank : 59)	θ value	0.0148317 (rank : 171)
Query Neighborhood Hits	293	Target Neighborhood Hits	310	Shared Neighborhood Hits	157
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRAP2_HUMAN
NC score	0.428597 (rank : 60)	θ value	0.00509761 (rank : 127)
Query Neighborhood Hits	293	Target Neighborhood Hits	304	Shared Neighborhood Hits	158
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_MOUSE
NC score	0.427918 (rank : 61)	θ value	0.0148317 (rank : 172)
Query Neighborhood Hits	293	Target Neighborhood Hits	312	Shared Neighborhood Hits	157
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAM1_MOUSE
NC score	0.419379 (rank : 62)	θ value	0.000121331 (rank : 66)
Query Neighborhood Hits	293	Target Neighborhood Hits	273	Shared Neighborhood Hits	149
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF1_MOUSE
NC score	0.416984 (rank : 63)	θ value	0.00035302 (rank : 78)
Query Neighborhood Hits	293	Target Neighborhood Hits	198	Shared Neighborhood Hits	140
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

STAM1_HUMAN
NC score	0.416785 (rank : 64)	θ value	0.00020696 (rank : 76)
Query Neighborhood Hits	293	Target Neighborhood Hits	271	Shared Neighborhood Hits	150
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCK1_HUMAN
NC score	0.408168 (rank : 65)	θ value	0.0252991 (rank : 191)
Query Neighborhood Hits	293	Target Neighborhood Hits	312	Shared Neighborhood Hits	162
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP_MOUSE
NC score	0.408127 (rank : 66)	θ value	0.0563607 (rank : 204)
Query Neighborhood Hits	293	Target Neighborhood Hits	309	Shared Neighborhood Hits	159
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCF1_HUMAN
NC score	0.406031 (rank : 67)	θ value	0.00665767 (rank : 150)
Query Neighborhood Hits	293	Target Neighborhood Hits	198	Shared Neighborhood Hits	137
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ARHG7_MOUSE
NC score	0.405591 (rank : 68)	θ value	0.000602161 (rank : 83)
Query Neighborhood Hits	293	Target Neighborhood Hits	396	Shared Neighborhood Hits	158
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NCK2_HUMAN
NC score	0.404482 (rank : 69)	θ value	0.0961366 (rank : 214)
Query Neighborhood Hits	293	Target Neighborhood Hits	310	Shared Neighborhood Hits	159
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_HUMAN
NC score	0.404163 (rank : 70)	θ value	0.0563607 (rank : 203)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	155
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ARHG7_HUMAN
NC score	0.400037 (rank : 71)	θ value	0.000602161 (rank : 82)
Query Neighborhood Hits	293	Target Neighborhood Hits	347	Shared Neighborhood Hits	158
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PINC_HUMAN
NC score	0.399649 (rank : 72)	θ value	0.00298849 (rank : 111)
Query Neighborhood Hits	293	Target Neighborhood Hits	231	Shared Neighborhood Hits	101
SwissProt Accessions	P48059, Q53TE0, Q9BS44	Gene names	LIMS1
Domain Architecture
Description	Protein PINCH (Particularly interesting new Cys-His protein) (LIM and senescent cell antigen-like domains 1) (NY-REN-48 antigen).

PAXI_MOUSE
NC score	0.393587 (rank : 73)	θ value	0.00509761 (rank : 136)
Query Neighborhood Hits	293	Target Neighborhood Hits	176	Shared Neighborhood Hits	101
SwissProt Accessions	Q8VI36, Q3TB62, Q3TZQ6, Q8VI37	Gene names	Pxn
Domain Architecture	No domain graphic available
Description	Paxillin.

LPXN_HUMAN
NC score	0.393537 (rank : 74)	θ value	0.00665767 (rank : 148)
Query Neighborhood Hits	293	Target Neighborhood Hits	159	Shared Neighborhood Hits	101
SwissProt Accessions	O60711	Gene names	LPXN, LDLP
Domain Architecture
Description	Leupaxin.

PAXI_HUMAN
NC score	0.393288 (rank : 75)	θ value	0.00509761 (rank : 135)
Query Neighborhood Hits	293	Target Neighborhood Hits	173	Shared Neighborhood Hits	101
SwissProt Accessions	P49023, O14970, O14971, O60360	Gene names	PXN
Domain Architecture
Description	Paxillin.

CRKL_HUMAN
NC score	0.392336 (rank : 76)	θ value	0.0252991 (rank : 189)
Query Neighborhood Hits	293	Target Neighborhood Hits	313	Shared Neighborhood Hits	150
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

LIMA1_MOUSE
NC score	0.392047 (rank : 77)	θ value	6.43352e-06 (rank : 36)
Query Neighborhood Hits	293	Target Neighborhood Hits	298	Shared Neighborhood Hits	102
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

ABLM3_MOUSE
NC score	0.390334 (rank : 78)	θ value	0.000158464 (rank : 68)
Query Neighborhood Hits	293	Target Neighborhood Hits	294	Shared Neighborhood Hits	108
SwissProt Accessions	Q69ZX8, Q52KR1, Q6PAI7	Gene names	Ablim3, Kiaa0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

ABLM3_HUMAN
NC score	0.389442 (rank : 79)	θ value	0.00020696 (rank : 70)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	108
SwissProt Accessions	O94929, Q658S1, Q68CI5, Q9BV32	Gene names	ABLIM3, KIAA0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

DNMBP_HUMAN
NC score	0.389123 (rank : 80)	θ value	0.0148317 (rank : 170)
Query Neighborhood Hits	293	Target Neighborhood Hits	413	Shared Neighborhood Hits	169
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CRKL_MOUSE
NC score	0.388549 (rank : 81)	θ value	0.0148317 (rank : 169)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	144
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ABLM2_MOUSE
NC score	0.386599 (rank : 82)	θ value	5.44631e-05 (rank : 52)
Query Neighborhood Hits	293	Target Neighborhood Hits	306	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BL65, Q6H8P8, Q80WK6, Q8BUT1, Q8BXI7	Gene names	Ablim2
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 2 (Actin-binding LIM protein family member 2) (abLIM-2).

LPXN_MOUSE
NC score	0.385612 (rank : 83)	θ value	0.0113563 (rank : 163)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	101
SwissProt Accessions	Q99N69	Gene names	Lpxn
Domain Architecture	No domain graphic available
Description	Leupaxin.

ABLM2_HUMAN
NC score	0.384036 (rank : 84)	θ value	0.000121331 (rank : 63)
Query Neighborhood Hits	293	Target Neighborhood Hits	317	Shared Neighborhood Hits	103
SwissProt Accessions	Q6H8Q1, Q6H8Q0, Q6NX73, Q8N3C5, Q8N9E9, Q8N9G2, Q96JL7	Gene names	ABLIM2, KIAA1808
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 2 (Actin-binding LIM protein family member 2) (abLIM-2).

DNMBP_MOUSE
NC score	0.383658 (rank : 85)	θ value	0.0193708 (rank : 178)
Query Neighborhood Hits	293	Target Neighborhood Hits	435	Shared Neighborhood Hits	172
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PDLI7_MOUSE
NC score	0.383591 (rank : 86)	θ value	0.000121331 (rank : 65)
Query Neighborhood Hits	293	Target Neighborhood Hits	279	Shared Neighborhood Hits	105
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

FBLI1_HUMAN
NC score	0.383409 (rank : 87)	θ value	0.00665767 (rank : 144)
Query Neighborhood Hits	293	Target Neighborhood Hits	200	Shared Neighborhood Hits	106
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

LIMA1_HUMAN
NC score	0.381937 (rank : 88)	θ value	5.44631e-05 (rank : 55)
Query Neighborhood Hits	293	Target Neighborhood Hits	309	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

STAM2_MOUSE
NC score	0.380826 (rank : 89)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	293	Target Neighborhood Hits	285	Shared Neighborhood Hits	148
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ARHG6_HUMAN
NC score	0.379935 (rank : 90)	θ value	0.00869519 (rank : 154)
Query Neighborhood Hits	293	Target Neighborhood Hits	376	Shared Neighborhood Hits	154
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.379885 (rank : 91)	θ value	0.0148317 (rank : 168)
Query Neighborhood Hits	293	Target Neighborhood Hits	394	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ABLM1_MOUSE
NC score	0.378697 (rank : 92)	θ value	0.000121331 (rank : 62)
Query Neighborhood Hits	293	Target Neighborhood Hits	356	Shared Neighborhood Hits	104
SwissProt Accessions	Q8K4G5, Q80U86, Q8BIR9, Q8K4G3, Q8K4G4	Gene names	Ablim1, Ablim, Kiaa0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1).

FHL3_MOUSE
NC score	0.374018 (rank : 93)	θ value	0.00509761 (rank : 126)
Query Neighborhood Hits	293	Target Neighborhood Hits	424	Shared Neighborhood Hits	106
SwissProt Accessions	Q9R059, Q9JLP5, Q9WUH3	Gene names	Fhl3
Domain Architecture
Description	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2).

ABLM1_HUMAN
NC score	0.373598 (rank : 94)	θ value	0.000158464 (rank : 67)
Query Neighborhood Hits	293	Target Neighborhood Hits	387	Shared Neighborhood Hits	103
SwissProt Accessions	O14639, Q15039, Q68CQ9, Q9BUP1	Gene names	ABLIM1, ABLIM, KIAA0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1) (Actin-binding double-zinc-finger protein) (LIMAB1) (Limatin).

PDLI7_HUMAN
NC score	0.370913 (rank : 95)	θ value	0.000602161 (rank : 86)
Query Neighborhood Hits	293	Target Neighborhood Hits	547	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

OSTF1_HUMAN
NC score	0.370560 (rank : 96)	θ value	0.00020696 (rank : 73)
Query Neighborhood Hits	293	Target Neighborhood Hits	466	Shared Neighborhood Hits	155
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

STAM2_HUMAN
NC score	0.370515 (rank : 97)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	293	Target Neighborhood Hits	288	Shared Neighborhood Hits	147
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

FHL3_HUMAN
NC score	0.369564 (rank : 98)	θ value	0.21417 (rank : 222)
Query Neighborhood Hits	293	Target Neighborhood Hits	354	Shared Neighborhood Hits	104
SwissProt Accessions	Q13643	Gene names	FHL3, SLIM2
Domain Architecture
Description	Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM- protein 2) (SLIM 2).

PDLI5_MOUSE
NC score	0.369041 (rank : 99)	θ value	0.00390308 (rank : 116)
Query Neighborhood Hits	293	Target Neighborhood Hits	287	Shared Neighborhood Hits	101
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

FBLI1_MOUSE
NC score	0.369019 (rank : 100)	θ value	0.163984 (rank : 219)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	106
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

PDLI5_HUMAN
NC score	0.368492 (rank : 101)	θ value	0.00390308 (rank : 115)
Query Neighborhood Hits	293	Target Neighborhood Hits	322	Shared Neighborhood Hits	102
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

CRK_MOUSE
NC score	0.368448 (rank : 102)	θ value	0.0431538 (rank : 200)
Query Neighborhood Hits	293	Target Neighborhood Hits	314	Shared Neighborhood Hits	151
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC_HUMAN
NC score	0.366562 (rank : 103)	θ value	2.36792 (rank : 274)
Query Neighborhood Hits	293	Target Neighborhood Hits	276	Shared Neighborhood Hits	145
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

LIMD1_HUMAN
NC score	0.365510 (rank : 104)	θ value	0.00665767 (rank : 145)
Query Neighborhood Hits	293	Target Neighborhood Hits	201	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

CRK_HUMAN
NC score	0.365011 (rank : 105)	θ value	0.0431538 (rank : 199)
Query Neighborhood Hits	293	Target Neighborhood Hits	308	Shared Neighborhood Hits	151
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

OSTF1_MOUSE
NC score	0.362737 (rank : 106)	θ value	0.000158464 (rank : 69)
Query Neighborhood Hits	293	Target Neighborhood Hits	467	Shared Neighborhood Hits	156
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PEX13_HUMAN
NC score	0.359921 (rank : 107)	θ value	0.00390308 (rank : 117)
Query Neighborhood Hits	293	Target Neighborhood Hits	128	Shared Neighborhood Hits	106
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

LIMD1_MOUSE
NC score	0.359872 (rank : 108)	θ value	0.00665767 (rank : 146)
Query Neighborhood Hits	293	Target Neighborhood Hits	291	Shared Neighborhood Hits	108
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

ZYX_HUMAN
NC score	0.359539 (rank : 109)	θ value	0.0330416 (rank : 198)
Query Neighborhood Hits	293	Target Neighborhood Hits	387	Shared Neighborhood Hits	110
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ZYX_MOUSE
NC score	0.359489 (rank : 110)	θ value	0.0252991 (rank : 194)
Query Neighborhood Hits	293	Target Neighborhood Hits	347	Shared Neighborhood Hits	110
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

STAC_MOUSE
NC score	0.359069 (rank : 111)	θ value	1.81305 (rank : 269)
Query Neighborhood Hits	293	Target Neighborhood Hits	268	Shared Neighborhood Hits	144
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TRIP6_HUMAN
NC score	0.355822 (rank : 112)	θ value	0.00390308 (rank : 122)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	95
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

LDB3_HUMAN
NC score	0.355174 (rank : 113)	θ value	0.0148317 (rank : 173)
Query Neighborhood Hits	293	Target Neighborhood Hits	497	Shared Neighborhood Hits	110
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
NC score	0.354416 (rank : 114)	θ value	0.0148317 (rank : 174)
Query Neighborhood Hits	293	Target Neighborhood Hits	510	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LPP_MOUSE
NC score	0.350730 (rank : 115)	θ value	0.00665767 (rank : 147)
Query Neighborhood Hits	293	Target Neighborhood Hits	247	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

PRIC2_HUMAN
NC score	0.350619 (rank : 116)	θ value	0.00175202 (rank : 99)
Query Neighborhood Hits	293	Target Neighborhood Hits	197	Shared Neighborhood Hits	104
SwissProt Accessions	Q7Z3G6	Gene names	PRICKLE2
Domain Architecture	No domain graphic available
Description	Prickle-like protein 2.

PRIC2_MOUSE
NC score	0.349858 (rank : 117)	θ value	0.00175202 (rank : 100)
Query Neighborhood Hits	293	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q80Y24	Gene names	Prickle2
Domain Architecture	No domain graphic available
Description	Prickle-like protein 2.

VAV_MOUSE
NC score	0.348901 (rank : 118)	θ value	0.000461057 (rank : 81)
Query Neighborhood Hits	293	Target Neighborhood Hits	430	Shared Neighborhood Hits	162
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.347663 (rank : 119)	θ value	0.00509761 (rank : 141)
Query Neighborhood Hits	293	Target Neighborhood Hits	452	Shared Neighborhood Hits	160
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PEX13_MOUSE
NC score	0.347482 (rank : 120)	θ value	0.0193708 (rank : 183)
Query Neighborhood Hits	293	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

TES_HUMAN
NC score	0.346030 (rank : 121)	θ value	0.00509761 (rank : 140)
Query Neighborhood Hits	293	Target Neighborhood Hits	131	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UGI8, Q9GZQ1, Q9HAJ9	Gene names	TES
Domain Architecture
Description	Testin (TESS).

TES_MOUSE
NC score	0.341305 (rank : 122)	θ value	0.0113563 (rank : 167)
Query Neighborhood Hits	293	Target Neighborhood Hits	171	Shared Neighborhood Hits	100
SwissProt Accessions	P47226	Gene names	Tes
Domain Architecture
Description	Testin (TES1/TES2).

SNX18_MOUSE
NC score	0.338446 (rank : 123)	θ value	0.00390308 (rank : 120)
Query Neighborhood Hits	293	Target Neighborhood Hits	198	Shared Neighborhood Hits	120
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PRIC1_HUMAN
NC score	0.337372 (rank : 124)	θ value	0.0252991 (rank : 192)
Query Neighborhood Hits	293	Target Neighborhood Hits	187	Shared Neighborhood Hits	98
SwissProt Accessions	Q96MT3, Q71QF8, Q96N00	Gene names	PRICKLE1, RILP
Domain Architecture	No domain graphic available
Description	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1).

ITSN2_HUMAN
NC score	0.336960 (rank : 125)	θ value	4.1701e-05 (rank : 50)
Query Neighborhood Hits	293	Target Neighborhood Hits	1173	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

FHL5_MOUSE
NC score	0.336698 (rank : 126)	θ value	0.0193708 (rank : 179)
Query Neighborhood Hits	293	Target Neighborhood Hits	463	Shared Neighborhood Hits	103
SwissProt Accessions	Q9WTX7	Gene names	Fhl5, Act
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

SNX18_HUMAN
NC score	0.336094 (rank : 127)	θ value	0.00390308 (rank : 119)
Query Neighborhood Hits	293	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

FHL1_MOUSE
NC score	0.329423 (rank : 128)	θ value	0.125558 (rank : 216)
Query Neighborhood Hits	293	Target Neighborhood Hits	462	Shared Neighborhood Hits	104
SwissProt Accessions	P97447, O55181, Q8K318	Gene names	Fhl1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM) (KyoT) (RBP-associated molecule 14-1) (RAM14-1).

LMO6_MOUSE
NC score	0.328507 (rank : 129)	θ value	0.00298849 (rank : 107)
Query Neighborhood Hits	293	Target Neighborhood Hits	277	Shared Neighborhood Hits	93
SwissProt Accessions	Q80VL3, Q8CAY9	Gene names	Lmo6
Domain Architecture	No domain graphic available
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

FHL1_HUMAN
NC score	0.327385 (rank : 130)	θ value	0.0961366 (rank : 212)
Query Neighborhood Hits	293	Target Neighborhood Hits	436	Shared Neighborhood Hits	102
SwissProt Accessions	Q13642, O95212, Q13230, Q13645, Q5M7Y6, Q9NZ40, Q9UKZ8, Q9Y630	Gene names	FHL1, SLIM1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM).

LMO6_HUMAN
NC score	0.327368 (rank : 131)	θ value	0.00509761 (rank : 133)
Query Neighborhood Hits	293	Target Neighborhood Hits	337	Shared Neighborhood Hits	103
SwissProt Accessions	O43900, O76007	Gene names	LMO6
Domain Architecture
Description	LIM domain only protein 6 (Triple LIM domain protein 6).

AHI1_MOUSE
NC score	0.327019 (rank : 132)	θ value	0.00102713 (rank : 88)
Query Neighborhood Hits	293	Target Neighborhood Hits	496	Shared Neighborhood Hits	157
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NPHP1_MOUSE
NC score	0.323614 (rank : 133)	θ value	0.47712 (rank : 237)
Query Neighborhood Hits	293	Target Neighborhood Hits	267	Shared Neighborhood Hits	139
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

FHL5_HUMAN
NC score	0.322293 (rank : 134)	θ value	0.0113563 (rank : 161)
Query Neighborhood Hits	293	Target Neighborhood Hits	523	Shared Neighborhood Hits	102
SwissProt Accessions	Q5TD97, Q5TD98, Q8WW21, Q9NQU2	Gene names	FHL5, ACT
Domain Architecture	No domain graphic available
Description	Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP- responsive element modulator in testis) (Activator of CREM in testis).

CF049_HUMAN
NC score	0.321828 (rank : 135)	θ value	1.38821 (rank : 261)
Query Neighborhood Hits	293	Target Neighborhood Hits	123	Shared Neighborhood Hits	91
SwissProt Accessions	Q2TBC4, Q5T3D4, Q9NSV1	Gene names	C6orf49
Domain Architecture	No domain graphic available
Description	Protein C6orf49.

STAC3_MOUSE
NC score	0.321376 (rank : 136)	θ value	6.88961 (rank : 290)
Query Neighborhood Hits	293	Target Neighborhood Hits	232	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV2_MOUSE
NC score	0.321038 (rank : 137)	θ value	0.125558 (rank : 218)
Query Neighborhood Hits	293	Target Neighborhood Hits	456	Shared Neighborhood Hits	159
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

STAC3_HUMAN
NC score	0.320382 (rank : 138)	θ value	6.88961 (rank : 289)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	131
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV2_HUMAN
NC score	0.320165 (rank : 139)	θ value	0.163984 (rank : 220)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	158
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN2_MOUSE
NC score	0.320146 (rank : 140)	θ value	4.1701e-05 (rank : 51)
Query Neighborhood Hits	293	Target Neighborhood Hits	1371	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

AHI1_HUMAN
NC score	0.318648 (rank : 141)	θ value	0.0113563 (rank : 157)
Query Neighborhood Hits	293	Target Neighborhood Hits	537	Shared Neighborhood Hits	153
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ITSN1_MOUSE
NC score	0.314758 (rank : 142)	θ value	7.1131e-05 (rank : 60)
Query Neighborhood Hits	293	Target Neighborhood Hits	1669	Shared Neighborhood Hits	184
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

LMCD1_HUMAN
NC score	0.313907 (rank : 143)	θ value	0.0736092 (rank : 210)
Query Neighborhood Hits	293	Target Neighborhood Hits	108	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NZU5	Gene names	LMCD1
Domain Architecture
Description	LIM and cysteine-rich domains protein 1 (Dyxin).

PLCG1_MOUSE
NC score	0.312393 (rank : 144)	θ value	0.0193708 (rank : 184)
Query Neighborhood Hits	293	Target Neighborhood Hits	314	Shared Neighborhood Hits	142
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ITSN1_HUMAN
NC score	0.311499 (rank : 145)	θ value	0.000270298 (rank : 77)
Query Neighborhood Hits	293	Target Neighborhood Hits	1757	Shared Neighborhood Hits	182
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

LPP_HUMAN
NC score	0.310356 (rank : 146)	θ value	0.0148317 (rank : 175)
Query Neighborhood Hits	293	Target Neighborhood Hits	775	Shared Neighborhood Hits	115
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

LMCD1_MOUSE
NC score	0.308447 (rank : 147)	θ value	0.0961366 (rank : 213)
Query Neighborhood Hits	293	Target Neighborhood Hits	102	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VEE1	Gene names	Lmcd1
Domain Architecture
Description	LIM and cysteine-rich domains protein 1.

FHL2_HUMAN
NC score	0.308124 (rank : 148)	θ value	0.00175202 (rank : 96)
Query Neighborhood Hits	293	Target Neighborhood Hits	533	Shared Neighborhood Hits	101
SwissProt Accessions	Q14192, Q13229, Q13644, Q9P294	Gene names	FHL2, DRAL, SLIM3
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3) (LIM-domain protein DRAL).

PLCG2_HUMAN
NC score	0.308099 (rank : 149)	θ value	0.0193708 (rank : 185)
Query Neighborhood Hits	293	Target Neighborhood Hits	280	Shared Neighborhood Hits	136
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

RUSC1_HUMAN
NC score	0.304122 (rank : 150)	θ value	0.0148317 (rank : 176)
Query Neighborhood Hits	293	Target Neighborhood Hits	226	Shared Neighborhood Hits	114
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SHLB1_MOUSE
NC score	0.298657 (rank : 151)	θ value	0.00665767 (rank : 152)
Query Neighborhood Hits	293	Target Neighborhood Hits	101	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

FHL2_MOUSE
NC score	0.297230 (rank : 152)	θ value	0.000786445 (rank : 87)
Query Neighborhood Hits	293	Target Neighborhood Hits	539	Shared Neighborhood Hits	99
SwissProt Accessions	O70433, P97448	Gene names	Fhl2
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3).

PLCG1_HUMAN
NC score	0.296370 (rank : 153)	θ value	0.0961366 (rank : 215)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	137
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PDLI4_HUMAN
NC score	0.296294 (rank : 154)	θ value	9.29e-05 (rank : 61)
Query Neighborhood Hits	293	Target Neighborhood Hits	245	Shared Neighborhood Hits	99
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

VAV3_HUMAN
NC score	0.295705 (rank : 155)	θ value	1.06291 (rank : 259)
Query Neighborhood Hits	293	Target Neighborhood Hits	398	Shared Neighborhood Hits	152
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.295203 (rank : 156)	θ value	0.279714 (rank : 224)
Query Neighborhood Hits	293	Target Neighborhood Hits	404	Shared Neighborhood Hits	154
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

STS2_HUMAN
NC score	0.294692 (rank : 157)	θ value	0.00390308 (rank : 121)
Query Neighborhood Hits	293	Target Neighborhood Hits	108	Shared Neighborhood Hits	89
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RUSC1_MOUSE
NC score	0.293459 (rank : 158)	θ value	0.00390308 (rank : 118)
Query Neighborhood Hits	293	Target Neighborhood Hits	206	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

PDLI4_MOUSE
NC score	0.293419 (rank : 159)	θ value	0.00020696 (rank : 74)
Query Neighborhood Hits	293	Target Neighborhood Hits	233	Shared Neighborhood Hits	99
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

EFS_MOUSE
NC score	0.291997 (rank : 160)	θ value	0.47712 (rank : 233)
Query Neighborhood Hits	293	Target Neighborhood Hits	389	Shared Neighborhood Hits	134
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SHLB1_HUMAN
NC score	0.290765 (rank : 161)	θ value	0.0193708 (rank : 186)
Query Neighborhood Hits	293	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

LMO4_HUMAN
NC score	0.288436 (rank : 162)	θ value	1.81305 (rank : 265)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	95
SwissProt Accessions	P61968, O00158, O88894	Gene names	LMO4
Domain Architecture
Description	LIM domain transcription factor LMO4 (LIM domain only protein 4) (LMO- 4) (Breast tumor autoantigen).

LMO4_MOUSE
NC score	0.288436 (rank : 163)	θ value	1.81305 (rank : 266)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	95
SwissProt Accessions	P61969, O00158, O88894	Gene names	Lmo4
Domain Architecture
Description	LIM domain transcription factor LMO4 (LIM domain only protein 4) (LMO- 4) (Breast tumor autoantigen).

RBTN1_MOUSE
NC score	0.281661 (rank : 164)	θ value	0.47712 (rank : 239)
Query Neighborhood Hits	293	Target Neighborhood Hits	109	Shared Neighborhood Hits	93
SwissProt Accessions	Q924W9	Gene names	Lmo1, Rbtn1, Rhom1, Ttg1
Domain Architecture	No domain graphic available
Description	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM-only protein 1).

LMO3_HUMAN
NC score	0.281353 (rank : 165)	θ value	0.47712 (rank : 235)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	94
SwissProt Accessions	Q8TAP4, Q8N974, Q9UDD5	Gene names	LMO3, RBTN3, RHOM3
Domain Architecture
Description	LIM-only protein 3 (Neuronal-specific transcription factor DAT1) (Rhombotin-3).

LMO3_MOUSE
NC score	0.281353 (rank : 166)	θ value	0.47712 (rank : 236)
Query Neighborhood Hits	293	Target Neighborhood Hits	111	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BZL8	Gene names	Lmo3
Domain Architecture
Description	LIM-only protein 3 (Neuronal-specific transcription factor DAT1).

RBTN1_HUMAN
NC score	0.281131 (rank : 167)	θ value	0.47712 (rank : 238)
Query Neighborhood Hits	293	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	P25800, Q4VBC5	Gene names	LMO1, RBTN1, RHOM1, TTG1
Domain Architecture
Description	Rhombotin-1 (Cysteine-rich protein TTG-1) (T-cell translocation protein 1) (LIM-only protein 1).

EFS_HUMAN
NC score	0.280870 (rank : 168)	θ value	0.47712 (rank : 232)
Query Neighborhood Hits	293	Target Neighborhood Hits	348	Shared Neighborhood Hits	123
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SHLB2_MOUSE
NC score	0.275012 (rank : 169)	θ value	0.00298849 (rank : 112)
Query Neighborhood Hits	293	Target Neighborhood Hits	88	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

NPHP1_HUMAN
NC score	0.274275 (rank : 170)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	293	Target Neighborhood Hits	288	Shared Neighborhood Hits	127
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RBTN2_MOUSE
NC score	0.273950 (rank : 171)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	293	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P25801	Gene names	Lmo2, Rbtn-2, Rbtn2, Rhom-2
Domain Architecture
Description	Rhombotin-2 (Cysteine-rich protein TTG-2) (T-cell translocation protein 2) (LIM-only protein 2).

RBTN2_HUMAN
NC score	0.273941 (rank : 172)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	293	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P25791, Q9HD58	Gene names	LMO2, RBTN2, RHOM2, TTG2
Domain Architecture
Description	Rhombotin-2 (Cysteine-rich protein TTG-2) (T-cell translocation protein 2) (LIM-only protein 2).

CT032_HUMAN
NC score	0.272174 (rank : 173)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	293	Target Neighborhood Hits	235	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

SHLB2_HUMAN
NC score	0.271964 (rank : 174)	θ value	0.00509761 (rank : 139)
Query Neighborhood Hits	293	Target Neighborhood Hits	86	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

LHX9_HUMAN
NC score	0.269850 (rank : 175)	θ value	0.00509761 (rank : 130)
Query Neighborhood Hits	293	Target Neighborhood Hits	444	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NQ69, Q5VUE3, Q9BYU6, Q9NQ70	Gene names	LHX9
Domain Architecture
Description	LIM/homeobox protein Lhx9.

LHX9_MOUSE
NC score	0.269707 (rank : 176)	θ value	0.00509761 (rank : 131)
Query Neighborhood Hits	293	Target Neighborhood Hits	445	Shared Neighborhood Hits	102
SwissProt Accessions	Q9WUH2, Q9QYQ5, Q9QYQ6, Q9QZ00, Q9WU44	Gene names	Lhx9
Domain Architecture
Description	LIM/homeobox protein Lhx9.

STS1_MOUSE
NC score	0.269319 (rank : 177)	θ value	0.000461057 (rank : 80)
Query Neighborhood Hits	293	Target Neighborhood Hits	104	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_HUMAN
NC score	0.267783 (rank : 178)	θ value	0.00102713 (rank : 89)
Query Neighborhood Hits	293	Target Neighborhood Hits	106	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PDLI3_HUMAN
NC score	0.266674 (rank : 179)	θ value	0.00509761 (rank : 137)
Query Neighborhood Hits	293	Target Neighborhood Hits	199	Shared Neighborhood Hits	92
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
NC score	0.265001 (rank : 180)	θ value	0.00509761 (rank : 138)
Query Neighborhood Hits	293	Target Neighborhood Hits	197	Shared Neighborhood Hits	92
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

LHX61_MOUSE
NC score	0.264787 (rank : 181)	θ value	0.00509761 (rank : 129)
Query Neighborhood Hits	293	Target Neighborhood Hits	396	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R1R0, Q9R1R1	Gene names	Lhx6.1
Domain Architecture
Description	LIM/homeobox protein Lhx6.1.

BCAR1_HUMAN
NC score	0.264243 (rank : 182)	θ value	1.81305 (rank : 264)
Query Neighborhood Hits	293	Target Neighborhood Hits	554	Shared Neighborhood Hits	148
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
NC score	0.263020 (rank : 183)	θ value	3.0926 (rank : 275)
Query Neighborhood Hits	293	Target Neighborhood Hits	438	Shared Neighborhood Hits	146
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ANM2_HUMAN
NC score	0.262409 (rank : 184)	θ value	0.00020696 (rank : 71)
Query Neighborhood Hits	293	Target Neighborhood Hits	175	Shared Neighborhood Hits	126
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

LMX1A_MOUSE
NC score	0.259569 (rank : 185)	θ value	0.00228821 (rank : 103)
Query Neighborhood Hits	293	Target Neighborhood Hits	405	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JKU8	Gene names	Lmx1a
Domain Architecture
Description	LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1).

ARHG4_HUMAN
NC score	0.257711 (rank : 186)	θ value	0.47712 (rank : 228)
Query Neighborhood Hits	293	Target Neighborhood Hits	242	Shared Neighborhood Hits	139
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

LHX61_HUMAN
NC score	0.256501 (rank : 187)	θ value	0.00509761 (rank : 128)
Query Neighborhood Hits	293	Target Neighborhood Hits	412	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UPM6, Q5T7S8, Q9NTK3, Q9UPM5	Gene names	LHX6, LHX6.1
Domain Architecture
Description	LIM/homeobox protein Lhx6.1 (Lhx6).

LHX4_HUMAN
NC score	0.255345 (rank : 188)	θ value	0.0736092 (rank : 208)
Query Neighborhood Hits	293	Target Neighborhood Hits	455	Shared Neighborhood Hits	103
SwissProt Accessions	Q969G2, Q8NHE0, Q8TCJ1, Q8WWX2, Q969W2	Gene names	LHX4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LHX4_MOUSE
NC score	0.255100 (rank : 189)	θ value	0.0736092 (rank : 209)
Query Neighborhood Hits	293	Target Neighborhood Hits	457	Shared Neighborhood Hits	102
SwissProt Accessions	P53776, O08916, Q9R280	Gene names	Lhx4, Gsh-4, Gsh4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LHX8_MOUSE
NC score	0.254872 (rank : 190)	θ value	0.0252991 (rank : 190)
Query Neighborhood Hits	293	Target Neighborhood Hits	406	Shared Neighborhood Hits	93
SwissProt Accessions	O35652, O70163, O88707	Gene names	Lhx8, Lhx7
Domain Architecture
Description	LIM/homeobox protein Lhx8 (LIM homeodomain Lhx7) (L3).

LHX5_MOUSE
NC score	0.254750 (rank : 191)	θ value	0.0193708 (rank : 181)
Query Neighborhood Hits	293	Target Neighborhood Hits	456	Shared Neighborhood Hits	100
SwissProt Accessions	P61375, P50459	Gene names	Lhx5
Domain Architecture
Description	LIM/homeobox protein Lhx5.

LHX5_HUMAN
NC score	0.253749 (rank : 192)	θ value	0.0193708 (rank : 180)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	100
SwissProt Accessions	Q9H2C1	Gene names	LHX5
Domain Architecture
Description	LIM/homeobox protein Lhx5.

LMX1A_HUMAN
NC score	0.253047 (rank : 193)	θ value	0.0193708 (rank : 182)
Query Neighborhood Hits	293	Target Neighborhood Hits	406	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TE12, Q8TE11	Gene names	LMX1A
Domain Architecture
Description	LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1).

LHX2_HUMAN
NC score	0.252997 (rank : 194)	θ value	0.813845 (rank : 249)
Query Neighborhood Hits	293	Target Neighborhood Hits	432	Shared Neighborhood Hits	98
SwissProt Accessions	P50458, O95860, Q8N1Z3	Gene names	LHX2, LH2
Domain Architecture
Description	LIM/homeobox protein Lhx2 (Homeobox protein LH-2).

LHX2_MOUSE
NC score	0.252990 (rank : 195)	θ value	0.813845 (rank : 250)
Query Neighborhood Hits	293	Target Neighborhood Hits	431	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z0S2	Gene names	Lhx2
Domain Architecture
Description	LIM/homeobox protein Lhx2.

MICA3_HUMAN
NC score	0.251986 (rank : 196)	θ value	5.44631e-05 (rank : 56)
Query Neighborhood Hits	293	Target Neighborhood Hits	160	Shared Neighborhood Hits	86
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

NOXO1_MOUSE
NC score	0.250449 (rank : 197)	θ value	1.06291 (rank : 258)
Query Neighborhood Hits	293	Target Neighborhood Hits	114	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ANM2_MOUSE
NC score	0.248842 (rank : 198)	θ value	0.00134147 (rank : 90)
Query Neighborhood Hits	293	Target Neighborhood Hits	175	Shared Neighborhood Hits	124
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

LHX1_HUMAN
NC score	0.248730 (rank : 199)	θ value	0.0563607 (rank : 205)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	98
SwissProt Accessions	P48742, Q3MIW0	Gene names	LHX1, LIM1
Domain Architecture
Description	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1).

LHX1_MOUSE
NC score	0.248681 (rank : 200)	θ value	0.0563607 (rank : 206)
Query Neighborhood Hits	293	Target Neighborhood Hits	453	Shared Neighborhood Hits	98
SwissProt Accessions	P63006, P36199	Gene names	Lhx1, Lim-1, Lim1
Domain Architecture	No domain graphic available
Description	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1).

LHX6_MOUSE
NC score	0.248131 (rank : 201)	θ value	0.0431538 (rank : 201)
Query Neighborhood Hits	293	Target Neighborhood Hits	399	Shared Neighborhood Hits	94
SwissProt Accessions	O88706	Gene names	Lhx6
Domain Architecture
Description	LIM/homeobox protein Lhx6.

LHX3_MOUSE
NC score	0.246017 (rank : 202)	θ value	0.279714 (rank : 223)
Query Neighborhood Hits	293	Target Neighborhood Hits	451	Shared Neighborhood Hits	103
SwissProt Accessions	P50481, Q61800, Q61801	Gene names	Lhx3, Lim-3, Lim3, Plim
Domain Architecture
Description	LIM/homeobox protein Lhx3 (Homeobox protein LIM-3) (Homeobox protein P-LIM) (LIM homeobox protein 3).

LHX3_HUMAN
NC score	0.243163 (rank : 203)	θ value	0.62314 (rank : 243)
Query Neighborhood Hits	293	Target Neighborhood Hits	474	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UBR4, Q9NZB5, Q9P0I8, Q9P0I9	Gene names	LHX3
Domain Architecture
Description	LIM/homeobox protein Lhx3.

LMX1B_MOUSE
NC score	0.240904 (rank : 204)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	293	Target Neighborhood Hits	394	Shared Neighborhood Hits	93
SwissProt Accessions	O88609	Gene names	Lmx1b
Domain Architecture
Description	LIM homeobox transcription factor 1 beta (LIM/homeobox protein LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2).

LMX1B_HUMAN
NC score	0.240614 (rank : 205)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	293	Target Neighborhood Hits	404	Shared Neighborhood Hits	93
SwissProt Accessions	O60663, O75463	Gene names	LMX1B
Domain Architecture
Description	LIM homeobox transcription factor 1 beta (LIM/homeobox protein LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2).

ISL2_HUMAN
NC score	0.233782 (rank : 206)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	293	Target Neighborhood Hits	435	Shared Neighborhood Hits	96
SwissProt Accessions	Q96A47	Gene names	ISL2
Domain Architecture
Description	Insulin gene enhancer protein ISL-2 (Islet-2).

ISL2_MOUSE
NC score	0.233422 (rank : 207)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	293	Target Neighborhood Hits	426	Shared Neighborhood Hits	96
SwissProt Accessions	Q9CXV0	Gene names	Isl2
Domain Architecture
Description	Insulin gene enhancer protein ISL-2 (Islet-2).

SPN90_HUMAN
NC score	0.233033 (rank : 208)	θ value	0.0252991 (rank : 193)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

DDEF1_MOUSE
NC score	0.232287 (rank : 209)	θ value	0.00175202 (rank : 95)
Query Neighborhood Hits	293	Target Neighborhood Hits	592	Shared Neighborhood Hits	131
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RHG26_HUMAN
NC score	0.231956 (rank : 210)	θ value	0.00665767 (rank : 151)
Query Neighborhood Hits	293	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ISL1_HUMAN
NC score	0.229785 (rank : 211)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	293	Target Neighborhood Hits	421	Shared Neighborhood Hits	93
SwissProt Accessions	P61371, P20663, P47894	Gene names	ISL1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

ISL1_MOUSE
NC score	0.229785 (rank : 212)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	293	Target Neighborhood Hits	421	Shared Neighborhood Hits	93
SwissProt Accessions	P61372, P20663, P47894, Q812D8	Gene names	Isl1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

MICA1_HUMAN
NC score	0.227660 (rank : 213)	θ value	0.000121331 (rank : 64)
Query Neighborhood Hits	293	Target Neighborhood Hits	279	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

ARHG5_HUMAN
NC score	0.225245 (rank : 214)	θ value	0.0330416 (rank : 195)
Query Neighborhood Hits	293	Target Neighborhood Hits	172	Shared Neighborhood Hits	96
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

MICA2_MOUSE
NC score	0.225037 (rank : 215)	θ value	0.00175202 (rank : 98)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BML1, Q3UPU6	Gene names	Mical2
Domain Architecture
Description	Protein MICAL-2.

CASL_MOUSE
NC score	0.222918 (rank : 216)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	125
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

MICA2_HUMAN
NC score	0.221906 (rank : 217)	θ value	0.00134147 (rank : 92)
Query Neighborhood Hits	293	Target Neighborhood Hits	174	Shared Neighborhood Hits	82
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

ARHG9_MOUSE
NC score	0.220672 (rank : 218)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	293	Target Neighborhood Hits	234	Shared Neighborhood Hits	131
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.220633 (rank : 219)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	293	Target Neighborhood Hits	235	Shared Neighborhood Hits	134
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SPN90_MOUSE
NC score	0.218973 (rank : 220)	θ value	0.0193708 (rank : 187)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

CASL_HUMAN
NC score	0.217749 (rank : 221)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	293	Target Neighborhood Hits	259	Shared Neighborhood Hits	121
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DDEF2_MOUSE
NC score	0.214233 (rank : 222)	θ value	0.00390308 (rank : 114)
Query Neighborhood Hits	293	Target Neighborhood Hits	625	Shared Neighborhood Hits	131
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.213110 (rank : 223)	θ value	0.00390308 (rank : 113)
Query Neighborhood Hits	293	Target Neighborhood Hits	599	Shared Neighborhood Hits	131
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

AMPH_HUMAN
NC score	0.212922 (rank : 224)	θ value	0.00298849 (rank : 104)
Query Neighborhood Hits	293	Target Neighborhood Hits	455	Shared Neighborhood Hits	84
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

MYO1F_HUMAN
NC score	0.211021 (rank : 225)	θ value	5.44631e-05 (rank : 57)
Query Neighborhood Hits	293	Target Neighborhood Hits	275	Shared Neighborhood Hits	146
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

BIN1_MOUSE
NC score	0.210718 (rank : 226)	θ value	0.0193708 (rank : 177)
Query Neighborhood Hits	293	Target Neighborhood Hits	283	Shared Neighborhood Hits	77
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

MYO1F_MOUSE
NC score	0.210283 (rank : 227)	θ value	5.44631e-05 (rank : 58)
Query Neighborhood Hits	293	Target Neighborhood Hits	262	Shared Neighborhood Hits	147
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

BIN1_HUMAN
NC score	0.208958 (rank : 228)	θ value	0.0113563 (rank : 158)
Query Neighborhood Hits	293	Target Neighborhood Hits	335	Shared Neighborhood Hits	74
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

IASPP_HUMAN
NC score	0.208435 (rank : 229)	θ value	1.38821 (rank : 262)
Query Neighborhood Hits	293	Target Neighborhood Hits	688	Shared Neighborhood Hits	134
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PDLI1_HUMAN
NC score	0.204622 (rank : 230)	θ value	1.81305 (rank : 267)
Query Neighborhood Hits	293	Target Neighborhood Hits	242	Shared Neighborhood Hits	77
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RIMB2_HUMAN
NC score	0.203719 (rank : 231)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	293	Target Neighborhood Hits	263	Shared Neighborhood Hits	101
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

MYO1E_HUMAN
NC score	0.203596 (rank : 232)	θ value	0.00298849 (rank : 109)
Query Neighborhood Hits	293	Target Neighborhood Hits	293	Shared Neighborhood Hits	157
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MICA1_MOUSE
NC score	0.202749 (rank : 233)	θ value	0.00298849 (rank : 108)
Query Neighborhood Hits	293	Target Neighborhood Hits	400	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MICA3_MOUSE
NC score	0.199590 (rank : 234)	θ value	0.00134147 (rank : 93)
Query Neighborhood Hits	293	Target Neighborhood Hits	104	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CJ19, Q80TE8, Q8BXB1	Gene names	Mical3, Kiaa1364
Domain Architecture
Description	Protein MICAL-3.

ES8L3_MOUSE
NC score	0.198893 (rank : 235)	θ value	0.47712 (rank : 234)
Query Neighborhood Hits	293	Target Neighborhood Hits	168	Shared Neighborhood Hits	119
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

P85A_MOUSE
NC score	0.197500 (rank : 236)	θ value	0.00298849 (rank : 110)
Query Neighborhood Hits	293	Target Neighborhood Hits	435	Shared Neighborhood Hits	108
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RIMB2_MOUSE
NC score	0.196416 (rank : 237)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	293	Target Neighborhood Hits	246	Shared Neighborhood Hits	91
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

NGEF_HUMAN
NC score	0.192981 (rank : 238)	θ value	0.365318 (rank : 226)
Query Neighborhood Hits	293	Target Neighborhood Hits	166	Shared Neighborhood Hits	79
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

IASPP_MOUSE
NC score	0.192307 (rank : 239)	θ value	1.06291 (rank : 254)
Query Neighborhood Hits	293	Target Neighborhood Hits	1024	Shared Neighborhood Hits	143
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ASPP1_MOUSE
NC score	0.192295 (rank : 240)	θ value	0.47712 (rank : 229)
Query Neighborhood Hits	293	Target Neighborhood Hits	1244	Shared Neighborhood Hits	153
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NGEF_MOUSE
NC score	0.191978 (rank : 241)	θ value	0.62314 (rank : 244)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	82
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
NC score	0.191613 (rank : 242)	θ value	0.00298849 (rank : 105)
Query Neighborhood Hits	293	Target Neighborhood Hits	152	Shared Neighborhood Hits	66
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AMPH_MOUSE
NC score	0.191442 (rank : 243)	θ value	1.38821 (rank : 260)
Query Neighborhood Hits	293	Target Neighborhood Hits	291	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BAIP2_MOUSE
NC score	0.189874 (rank : 244)	θ value	0.00509761 (rank : 125)
Query Neighborhood Hits	293	Target Neighborhood Hits	185	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ASPP1_HUMAN
NC score	0.189535 (rank : 245)	θ value	0.813845 (rank : 247)
Query Neighborhood Hits	293	Target Neighborhood Hits	956	Shared Neighborhood Hits	145
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAIP2_HUMAN
NC score	0.188919 (rank : 246)	θ value	0.00509761 (rank : 124)
Query Neighborhood Hits	293	Target Neighborhood Hits	192	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

RHG04_HUMAN
NC score	0.188522 (rank : 247)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	293	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PDLI1_MOUSE
NC score	0.188043 (rank : 248)	θ value	3.0926 (rank : 280)
Query Neighborhood Hits	293	Target Neighborhood Hits	213	Shared Neighborhood Hits	68
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

P85A_HUMAN
NC score	0.187548 (rank : 249)	θ value	0.00869519 (rank : 156)
Query Neighborhood Hits	293	Target Neighborhood Hits	479	Shared Neighborhood Hits	102
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BI2L1_HUMAN
NC score	0.185479 (rank : 250)	θ value	0.0252991 (rank : 188)
Query Neighborhood Hits	293	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SNX9_HUMAN
NC score	0.185331 (rank : 251)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	293	Target Neighborhood Hits	148	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

NOXO1_HUMAN
NC score	0.182506 (rank : 252)	θ value	3.0926 (rank : 279)
Query Neighborhood Hits	293	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ARHG4_MOUSE
NC score	0.179810 (rank : 253)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	293	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RASA1_HUMAN
NC score	0.176074 (rank : 254)	θ value	0.00020696 (rank : 75)
Query Neighborhood Hits	293	Target Neighborhood Hits	258	Shared Neighborhood Hits	68
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ARHGG_HUMAN
NC score	0.173424 (rank : 255)	θ value	0.00175202 (rank : 94)
Query Neighborhood Hits	293	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

JIP2_MOUSE
NC score	0.172942 (rank : 256)	θ value	0.0330416 (rank : 197)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

MILK2_HUMAN
NC score	0.171936 (rank : 257)	θ value	0.0113563 (rank : 164)
Query Neighborhood Hits	293	Target Neighborhood Hits	457	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

JIP2_HUMAN
NC score	0.170665 (rank : 258)	θ value	0.0330416 (rank : 196)
Query Neighborhood Hits	293	Target Neighborhood Hits	288	Shared Neighborhood Hits	64
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SRGP2_MOUSE
NC score	0.170324 (rank : 259)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	293	Target Neighborhood Hits	324	Shared Neighborhood Hits	132
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ES8L3_HUMAN
NC score	0.169811 (rank : 260)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	293	Target Neighborhood Hits	206	Shared Neighborhood Hits	108
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

BI2L1_MOUSE
NC score	0.168819 (rank : 261)	θ value	0.813845 (rank : 248)
Query Neighborhood Hits	293	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SRGP2_HUMAN
NC score	0.168363 (rank : 262)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	293	Target Neighborhood Hits	331	Shared Neighborhood Hits	131
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SNX9_MOUSE
NC score	0.166110 (rank : 263)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	293	Target Neighborhood Hits	141	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

MILK1_MOUSE
NC score	0.164944 (rank : 264)	θ value	0.365318 (rank : 225)
Query Neighborhood Hits	293	Target Neighborhood Hits	788	Shared Neighborhood Hits	98
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

FNBP2_HUMAN
NC score	0.164699 (rank : 265)	θ value	3.0926 (rank : 278)
Query Neighborhood Hits	293	Target Neighborhood Hits	432	Shared Neighborhood Hits	127
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SPTA2_HUMAN
NC score	0.164120 (rank : 266)	θ value	6.88961 (rank : 288)
Query Neighborhood Hits	293	Target Neighborhood Hits	888	Shared Neighborhood Hits	153
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DOCK1_HUMAN
NC score	0.163874 (rank : 267)	θ value	0.0113563 (rank : 159)
Query Neighborhood Hits	293	Target Neighborhood Hits	191	Shared Neighborhood Hits	109
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SLAP2_HUMAN
NC score	0.159604 (rank : 268)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	293	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
NC score	0.159539 (rank : 269)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	293	Target Neighborhood Hits	136	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPTA1_MOUSE
NC score	0.157845 (rank : 270)	θ value	0.365318 (rank : 227)
Query Neighborhood Hits	293	Target Neighborhood Hits	675	Shared Neighborhood Hits	136
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

FYN_MOUSE
NC score	0.157477 (rank : 271)	θ value	5.44631e-05 (rank : 54)
Query Neighborhood Hits	293	Target Neighborhood Hits	1073	Shared Neighborhood Hits	161
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SPTA1_HUMAN
NC score	0.157001 (rank : 272)	θ value	0.0563607 (rank : 207)
Query Neighborhood Hits	293	Target Neighborhood Hits	748	Shared Neighborhood Hits	145
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

LIMK1_MOUSE
NC score	0.156156 (rank : 273)	θ value	0.00298849 (rank : 106)
Query Neighborhood Hits	293	Target Neighborhood Hits	1008	Shared Neighborhood Hits	134
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

SRGP1_HUMAN
NC score	0.155789 (rank : 274)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	293	Target Neighborhood Hits	390	Shared Neighborhood Hits	122
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

LIMK1_HUMAN
NC score	0.155611 (rank : 275)	θ value	0.00509761 (rank : 132)
Query Neighborhood Hits	293	Target Neighborhood Hits	1005	Shared Neighborhood Hits	135
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

FYN_HUMAN
NC score	0.154469 (rank : 276)	θ value	5.44631e-05 (rank : 53)
Query Neighborhood Hits	293	Target Neighborhood Hits	1078	Shared Neighborhood Hits	161
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.153991 (rank : 277)	θ value	1.29631e-06 (rank : 34)
Query Neighborhood Hits	293	Target Neighborhood Hits	1058	Shared Neighborhood Hits	156
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGR_HUMAN
NC score	0.153058 (rank : 278)	θ value	0.00134147 (rank : 91)
Query Neighborhood Hits	293	Target Neighborhood Hits	1067	Shared Neighborhood Hits	155
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

P85B_HUMAN
NC score	0.152691 (rank : 279)	θ value	2.36792 (rank : 273)
Query Neighborhood Hits	293	Target Neighborhood Hits	543	Shared Neighborhood Hits	80
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SLAP1_HUMAN
NC score	0.152318 (rank : 280)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	293	Target Neighborhood Hits	113	Shared Neighborhood Hits	45
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.151681 (rank : 281)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	293	Target Neighborhood Hits	117	Shared Neighborhood Hits	46
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

P85B_MOUSE
NC score	0.151295 (rank : 282)	θ value	0.62314 (rank : 245)
Query Neighborhood Hits	293	Target Neighborhood Hits	519	Shared Neighborhood Hits	79
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PDLI2_HUMAN
NC score	0.148692 (rank : 283)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	293	Target Neighborhood Hits	245	Shared Neighborhood Hits	68
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

YES_MOUSE
NC score	0.148041 (rank : 284)	θ value	0.00390308 (rank : 123)
Query Neighborhood Hits	293	Target Neighborhood Hits	1052	Shared Neighborhood Hits	151
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PDLI2_MOUSE
NC score	0.147370 (rank : 285)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	293	Target Neighborhood Hits	220	Shared Neighborhood Hits	69
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

M3KL4_HUMAN
NC score	0.146968 (rank : 286)	θ value	0.00020696 (rank : 72)
Query Neighborhood Hits	293	Target Neighborhood Hits	1087	Shared Neighborhood Hits	152
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

YES_HUMAN
NC score	0.146906 (rank : 287)	θ value	0.00509761 (rank : 142)
Query Neighborhood Hits	293	Target Neighborhood Hits	1059	Shared Neighborhood Hits	153
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.146566 (rank : 288)	θ value	0.0113563 (rank : 160)
Query Neighborhood Hits	293	Target Neighborhood Hits	1069	Shared Neighborhood Hits	155
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ES8L2_HUMAN
NC score	0.146271 (rank : 289)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	293	Target Neighborhood Hits	193	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
NC score	0.141399 (rank : 290)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	293	Target Neighborhood Hits	169	Shared Neighborhood Hits	106
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MILK1_HUMAN
NC score	0.140792 (rank : 291)	θ value	5.27518 (rank : 286)
Query Neighborhood Hits	293	Target Neighborhood Hits	427	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

JIP1_MOUSE
NC score	0.139714 (rank : 292)	θ value	0.62314 (rank : 242)
Query Neighborhood Hits	293	Target Neighborhood Hits	259	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_HUMAN
NC score	0.139351 (rank : 293)	θ value	0.62314 (rank : 241)
Query Neighborhood Hits	293	Target Neighborhood Hits	271	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SRC_MOUSE
NC score	0.136859 (rank : 294)	θ value	1.87187e-05 (rank : 47)
Query Neighborhood Hits	293	Target Neighborhood Hits	1033	Shared Neighborhood Hits	145
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

LIMK2_MOUSE
NC score	0.136805 (rank : 295)	θ value	0.813845 (rank : 251)
Query Neighborhood Hits	293	Target Neighborhood Hits	998	Shared Neighborhood Hits	131
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

HCK_MOUSE
NC score	0.131987 (rank : 296)	θ value	0.00869519 (rank : 155)
Query Neighborhood Hits	293	Target Neighborhood Hits	1029	Shared Neighborhood Hits	151
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

LIMK2_HUMAN
NC score	0.131391 (rank : 297)	θ value	1.06291 (rank : 257)
Query Neighborhood Hits	293	Target Neighborhood Hits	986	Shared Neighborhood Hits	130
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

SHAN2_MOUSE
NC score	0.131328 (rank : 298)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	293	Target Neighborhood Hits	446	Shared Neighborhood Hits	100
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ASPP2_HUMAN
NC score	0.130830 (rank : 299)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	293	Target Neighborhood Hits	1156	Shared Neighborhood Hits	122
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

HCK_HUMAN
NC score	0.129581 (rank : 300)	θ value	0.0113563 (rank : 162)
Query Neighborhood Hits	293	Target Neighborhood Hits	1035	Shared Neighborhood Hits	149
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

CIP4_HUMAN
NC score	0.129077 (rank : 301)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	293	Target Neighborhood Hits	374	Shared Neighborhood Hits	61
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

M3K11_HUMAN
NC score	0.128356 (rank : 302)	θ value	0.0431538 (rank : 202)
Query Neighborhood Hits	293	Target Neighborhood Hits	1136	Shared Neighborhood Hits	151
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
NC score	0.124216 (rank : 303)	θ value	0.0736092 (rank : 211)
Query Neighborhood Hits	293	Target Neighborhood Hits	1123	Shared Neighborhood Hits	149
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

TCGAP_MOUSE
NC score	0.122541 (rank : 304)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	293	Target Neighborhood Hits	409	Shared Neighborhood Hits	109
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

M3K10_HUMAN
NC score	0.121505 (rank : 305)	θ value	0.00665767 (rank : 149)
Query Neighborhood Hits	293	Target Neighborhood Hits	1071	Shared Neighborhood Hits	139
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

P55G_HUMAN
NC score	0.120353 (rank : 306)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	293	Target Neighborhood Hits	451	Shared Neighborhood Hits	60
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

EPS8_MOUSE
NC score	0.119631 (rank : 307)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	103
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

BTK_HUMAN
NC score	0.119272 (rank : 308)	θ value	1.06291 (rank : 253)
Query Neighborhood Hits	293	Target Neighborhood Hits	1026	Shared Neighborhood Hits	151
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FRK_HUMAN
NC score	0.117731 (rank : 309)	θ value	0.125558 (rank : 217)
Query Neighborhood Hits	293	Target Neighborhood Hits	1058	Shared Neighborhood Hits	152
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

P55G_MOUSE
NC score	0.117144 (rank : 310)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	293	Target Neighborhood Hits	401	Shared Neighborhood Hits	54
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

EPS8_HUMAN
NC score	0.116210 (rank : 311)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	89
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

PPIP2_HUMAN
NC score	0.116124 (rank : 312)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	293	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

ES8L1_HUMAN
NC score	0.115488 (rank : 313)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	293	Target Neighborhood Hits	162	Shared Neighborhood Hits	87
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

LYN_HUMAN
NC score	0.114077 (rank : 314)	θ value	2.36792 (rank : 272)
Query Neighborhood Hits	293	Target Neighborhood Hits	1022	Shared Neighborhood Hits	135
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.114071 (rank : 315)	θ value	5.27518 (rank : 285)
Query Neighborhood Hits	293	Target Neighborhood Hits	1023	Shared Neighborhood Hits	136
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BTK_MOUSE
NC score	0.112611 (rank : 316)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	293	Target Neighborhood Hits	1017	Shared Neighborhood Hits	145
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

TCGAP_HUMAN
NC score	0.112271 (rank : 317)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	293	Target Neighborhood Hits	872	Shared Neighborhood Hits	120
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BLK_HUMAN
NC score	0.108913 (rank : 318)	θ value	3.0926 (rank : 276)
Query Neighborhood Hits	293	Target Neighborhood Hits	994	Shared Neighborhood Hits	128
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DAPP1_MOUSE
NC score	0.107653 (rank : 319)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RIMB1_HUMAN
NC score	0.106448 (rank : 320)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	293	Target Neighborhood Hits	1479	Shared Neighborhood Hits	119
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

DAPP1_HUMAN
NC score	0.106423 (rank : 321)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CSK_MOUSE
NC score	0.105876 (rank : 322)	θ value	0.47712 (rank : 231)
Query Neighborhood Hits	293	Target Neighborhood Hits	1009	Shared Neighborhood Hits	119
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.105863 (rank : 323)	θ value	0.47712 (rank : 230)
Query Neighborhood Hits	293	Target Neighborhood Hits	1009	Shared Neighborhood Hits	119
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

BLK_MOUSE
NC score	0.105651 (rank : 324)	θ value	5.27518 (rank : 283)
Query Neighborhood Hits	293	Target Neighborhood Hits	992	Shared Neighborhood Hits	116
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ES8L1_MOUSE
NC score	0.105537 (rank : 325)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	293	Target Neighborhood Hits	143	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SHAN1_HUMAN
NC score	0.105455 (rank : 326)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	293	Target Neighborhood Hits	1041	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

RIMB1_MOUSE
NC score	0.104391 (rank : 327)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	293	Target Neighborhood Hits	1376	Shared Neighborhood Hits	132
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PPIP2_MOUSE
NC score	0.104214 (rank : 328)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	293	Target Neighborhood Hits	308	Shared Neighborhood Hits	17
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PTK6_MOUSE
NC score	0.102868 (rank : 329)	θ value	0.62314 (rank : 246)
Query Neighborhood Hits	293	Target Neighborhood Hits	1026	Shared Neighborhood Hits	135
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK6_HUMAN
NC score	0.100352 (rank : 330)	θ value	1.81305 (rank : 268)
Query Neighborhood Hits	293	Target Neighborhood Hits	1020	Shared Neighborhood Hits	138
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

LCK_HUMAN
NC score	0.099522 (rank : 331)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	293	Target Neighborhood Hits	987	Shared Neighborhood Hits	111
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SH21B_MOUSE
NC score	0.099014 (rank : 332)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	293	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXK_MOUSE
NC score	0.098875 (rank : 333)	θ value	6.88961 (rank : 291)
Query Neighborhood Hits	293	Target Neighborhood Hits	980	Shared Neighborhood Hits	122
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LCK_MOUSE
NC score	0.098609 (rank : 334)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	293	Target Neighborhood Hits	981	Shared Neighborhood Hits	110
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

DEMA_HUMAN
NC score	0.096438 (rank : 335)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	293	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q08495, Q13215, Q9BRE3	Gene names	EPB49, DMT
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

DEMA_MOUSE
NC score	0.095470 (rank : 336)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	293	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WV69	Gene names	Epb49, Epb4.9
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

PKHG1_HUMAN
NC score	0.093988 (rank : 337)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	293	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

TEC_HUMAN
NC score	0.093674 (rank : 338)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	293	Target Neighborhood Hits	1006	Shared Neighborhood Hits	123
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHGF_HUMAN
NC score	0.093411 (rank : 339)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	293	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

SLY_MOUSE
NC score	0.093196 (rank : 340)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	293	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

RUSC2_MOUSE
NC score	0.092756 (rank : 341)	θ value	0.813845 (rank : 252)
Query Neighborhood Hits	293	Target Neighborhood Hits	305	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ARHG8_MOUSE
NC score	0.092082 (rank : 342)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	293	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG3_HUMAN
NC score	0.091648 (rank : 343)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	293	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

TEC_MOUSE
NC score	0.091551 (rank : 344)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	293	Target Neighborhood Hits	1006	Shared Neighborhood Hits	121
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHG3_MOUSE
NC score	0.091343 (rank : 345)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	293	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ABL1_MOUSE
NC score	0.090914 (rank : 346)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	293	Target Neighborhood Hits	1178	Shared Neighborhood Hits	115
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

RUSC2_HUMAN
NC score	0.090790 (rank : 347)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	293	Target Neighborhood Hits	205	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ABL1_HUMAN
NC score	0.089876 (rank : 348)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	293	Target Neighborhood Hits	1220	Shared Neighborhood Hits	118
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TXK_HUMAN
NC score	0.089558 (rank : 349)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	293	Target Neighborhood Hits	971	Shared Neighborhood Hits	109
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

SHB_MOUSE
NC score	0.089051 (rank : 350)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	293	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_MOUSE
NC score	0.088985 (rank : 351)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	293	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

TIAM1_MOUSE
NC score	0.088722 (rank : 352)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	293	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SHB_HUMAN
NC score	0.088060 (rank : 353)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	293	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SH21B_HUMAN
NC score	0.087177 (rank : 354)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	293	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SRMS_MOUSE
NC score	0.087126 (rank : 355)	θ value	0.47712 (rank : 240)
Query Neighborhood Hits	293	Target Neighborhood Hits	964	Shared Neighborhood Hits	95
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ITK_HUMAN
NC score	0.086796 (rank : 356)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	293	Target Neighborhood Hits	1016	Shared Neighborhood Hits	118
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ABL2_HUMAN
NC score	0.086492 (rank : 357)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	293	Target Neighborhood Hits	1045	Shared Neighborhood Hits	104
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

PREX1_HUMAN
NC score	0.086127 (rank : 358)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	293	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG8_HUMAN
NC score	0.086123 (rank : 359)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	293	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MCF2L_MOUSE
NC score	0.085810 (rank : 360)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	293	Target Neighborhood Hits	255	Shared Neighborhood Hits	44
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SHC3_MOUSE
NC score	0.084954 (rank : 361)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

TIAM1_HUMAN
NC score	0.084788 (rank : 362)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	24
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SHE_MOUSE
NC score	0.084123 (rank : 363)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	293	Target Neighborhood Hits	169	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

GRB14_MOUSE
NC score	0.083819 (rank : 364)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	293	Target Neighborhood Hits	149	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHC1_HUMAN
NC score	0.083439 (rank : 365)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	293	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHE_HUMAN
NC score	0.083230 (rank : 366)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	293	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ITK_MOUSE
NC score	0.083061 (rank : 367)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	293	Target Neighborhood Hits	985	Shared Neighborhood Hits	105
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

GRB14_HUMAN
NC score	0.082422 (rank : 368)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	293	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHC3_HUMAN
NC score	0.082044 (rank : 369)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	293	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHD_MOUSE
NC score	0.081888 (rank : 370)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	293	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

LMO7_HUMAN
NC score	0.081791 (rank : 371)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	293	Target Neighborhood Hits	507	Shared Neighborhood Hits	70
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

SHC2_HUMAN
NC score	0.079574 (rank : 372)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	293	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

HSH2D_HUMAN
NC score	0.079539 (rank : 373)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	293	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHC2_MOUSE
NC score	0.078620 (rank : 374)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

APS_HUMAN
NC score	0.078575 (rank : 375)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	293	Target Neighborhood Hits	162	Shared Neighborhood Hits	43
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SLY_HUMAN
NC score	0.077741 (rank : 376)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	293	Target Neighborhood Hits	81	Shared Neighborhood Hits	49
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SHD_HUMAN
NC score	0.077310 (rank : 377)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	293	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

FUT8_MOUSE
NC score	0.075754 (rank : 378)	θ value	5.27518 (rank : 284)
Query Neighborhood Hits	293	Target Neighborhood Hits	115	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

ARHGB_HUMAN
NC score	0.075612 (rank : 379)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	293	Target Neighborhood Hits	375	Shared Neighborhood Hits	36
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FUT8_HUMAN
NC score	0.074777 (rank : 380)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	293	Target Neighborhood Hits	67	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

ECT2_MOUSE
NC score	0.074722 (rank : 381)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	293	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SRMS_HUMAN
NC score	0.073769 (rank : 382)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	293	Target Neighborhood Hits	946	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

GRB7_MOUSE
NC score	0.073504 (rank : 383)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	293	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

ECT2_HUMAN
NC score	0.072457 (rank : 384)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	293	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

MATK_MOUSE
NC score	0.071476 (rank : 385)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	293	Target Neighborhood Hits	952	Shared Neighborhood Hits	74
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ARHG1_HUMAN
NC score	0.070700 (rank : 386)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	293	Target Neighborhood Hits	176	Shared Neighborhood Hits	20
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SH21A_HUMAN
NC score	0.070197 (rank : 387)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	293	Target Neighborhood Hits	89	Shared Neighborhood Hits	29
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

LNK_HUMAN
NC score	0.070147 (rank : 388)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_HUMAN
NC score	0.069921 (rank : 389)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	293	Target Neighborhood Hits	954	Shared Neighborhood Hits	70
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

LNK_MOUSE
NC score	0.069364 (rank : 390)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	293	Target Neighborhood Hits	132	Shared Neighborhood Hits	42
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ZN185_HUMAN
NC score	0.069341 (rank : 391)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	293	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

ARHGC_MOUSE
NC score	0.069246 (rank : 392)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	293	Target Neighborhood Hits	344	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.069166 (rank : 393)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	293	Target Neighborhood Hits	351	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGA_MOUSE
NC score	0.069050 (rank : 394)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	293	Target Neighborhood Hits	125	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2_HUMAN
NC score	0.068176 (rank : 395)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	293	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

SOCS7_MOUSE
NC score	0.067461 (rank : 396)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	293	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

ARHGA_HUMAN
NC score	0.066800 (rank : 397)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	293	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SH21A_MOUSE
NC score	0.066783 (rank : 398)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	293	Target Neighborhood Hits	89	Shared Neighborhood Hits	29
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

LCP2_MOUSE
NC score	0.066616 (rank : 399)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	293	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

S3TC2_MOUSE
NC score	0.066388 (rank : 400)	θ value	1.38821 (rank : 263)
Query Neighborhood Hits	293	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

EM55_HUMAN
NC score	0.066176 (rank : 401)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	293	Target Neighborhood Hits	228	Shared Neighborhood Hits	76
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

GRB7_HUMAN
NC score	0.066164 (rank : 402)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	293	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

ARHG1_MOUSE
NC score	0.066008 (rank : 403)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	293	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

GRB10_MOUSE
NC score	0.064527 (rank : 404)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	293	Target Neighborhood Hits	156	Shared Neighborhood Hits	44
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

SH24A_HUMAN
NC score	0.064526 (rank : 405)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	293	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH22A_MOUSE
NC score	0.064270 (rank : 406)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	293	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

EM55_MOUSE
NC score	0.063330 (rank : 407)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	293	Target Neighborhood Hits	221	Shared Neighborhood Hits	74
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

GRB10_HUMAN
NC score	0.062874 (rank : 408)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	293	Target Neighborhood Hits	147	Shared Neighborhood Hits	42
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

FGD4_MOUSE
NC score	0.061563 (rank : 409)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

LBC_HUMAN
NC score	0.061314 (rank : 410)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	293	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

SH22A_HUMAN
NC score	0.061032 (rank : 411)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	293	Target Neighborhood Hits	144	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

FER_HUMAN
NC score	0.060837 (rank : 412)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	293	Target Neighborhood Hits	1278	Shared Neighborhood Hits	68
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

GNRP_MOUSE
NC score	0.060723 (rank : 413)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	293	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG2_HUMAN
NC score	0.060617 (rank : 414)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	293	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

FGD4_HUMAN
NC score	0.060484 (rank : 415)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	293	Target Neighborhood Hits	219	Shared Neighborhood Hits	24
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

PTN11_MOUSE
NC score	0.060233 (rank : 416)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.060223 (rank : 417)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	293	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

ZAP70_MOUSE
NC score	0.059143 (rank : 418)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	293	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ARHG2_MOUSE
NC score	0.059134 (rank : 419)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	293	Target Neighborhood Hits	120	Shared Neighborhood Hits	23
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

LCP2_HUMAN
NC score	0.058690 (rank : 420)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	293	Target Neighborhood Hits	531	Shared Neighborhood Hits	48
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BMX_MOUSE
NC score	0.058661 (rank : 421)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	293	Target Neighborhood Hits	912	Shared Neighborhood Hits	53
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.058572 (rank : 422)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	293	Target Neighborhood Hits	942	Shared Neighborhood Hits	53
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

GNRP_HUMAN
NC score	0.058536 (rank : 423)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	293	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ZAP70_HUMAN
NC score	0.058170 (rank : 424)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	293	Target Neighborhood Hits	893	Shared Neighborhood Hits	57
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FGD3_MOUSE
NC score	0.057898 (rank : 425)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	293	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

KSYK_MOUSE
NC score	0.057795 (rank : 426)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	293	Target Neighborhood Hits	944	Shared Neighborhood Hits	59
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FGD2_HUMAN
NC score	0.057486 (rank : 427)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	293	Target Neighborhood Hits	151	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

KSYK_HUMAN
NC score	0.057046 (rank : 428)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	293	Target Neighborhood Hits	901	Shared Neighborhood Hits	57
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SOCS6_HUMAN
NC score	0.056668 (rank : 429)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	293	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SH2D3_MOUSE
NC score	0.056234 (rank : 430)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	293	Target Neighborhood Hits	174	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

RGNEF_MOUSE
NC score	0.056186 (rank : 431)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	293	Target Neighborhood Hits	641	Shared Neighborhood Hits	31
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ACK1_MOUSE
NC score	0.056080 (rank : 432)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	293	Target Neighborhood Hits	1080	Shared Neighborhood Hits	75
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

APS_MOUSE
NC score	0.055994 (rank : 433)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	293	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SOCS6_MOUSE
NC score	0.055763 (rank : 434)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	293	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

HAPIP_HUMAN
NC score	0.054970 (rank : 435)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	293	Target Neighborhood Hits	350	Shared Neighborhood Hits	27
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FGD3_HUMAN
NC score	0.054849 (rank : 436)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	293	Target Neighborhood Hits	249	Shared Neighborhood Hits	22
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ACK1_HUMAN
NC score	0.054816 (rank : 437)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	293	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

FGD2_MOUSE
NC score	0.053948 (rank : 438)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	293	Target Neighborhood Hits	163	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

GAS7_HUMAN
NC score	0.053475 (rank : 439)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	293	Target Neighborhood Hits	258	Shared Neighborhood Hits	13
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SH2D3_HUMAN
NC score	0.053452 (rank : 440)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	293	Target Neighborhood Hits	188	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

BCAR3_HUMAN
NC score	0.052121 (rank : 441)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	293	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

MPP6_HUMAN
NC score	0.051903 (rank : 442)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	293	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

PTN6_MOUSE
NC score	0.051902 (rank : 443)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SOCS2_MOUSE
NC score	0.051874 (rank : 444)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	293	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

ILK_MOUSE
NC score	0.051494 (rank : 445)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	293	Target Neighborhood Hits	858	Shared Neighborhood Hits	41
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

DREB_MOUSE
NC score	0.051391 (rank : 446)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	293	Target Neighborhood Hits	446	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

FGD1_HUMAN
NC score	0.051292 (rank : 447)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	293	Target Neighborhood Hits	367	Shared Neighborhood Hits	32
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

BCAR3_MOUSE
NC score	0.051281 (rank : 448)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	293	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ILK1_HUMAN
NC score	0.051268 (rank : 449)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	293	Target Neighborhood Hits	857	Shared Neighborhood Hits	41
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

DREB_HUMAN
NC score	0.050594 (rank : 450)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	293	Target Neighborhood Hits	450	Shared Neighborhood Hits	15
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ILK2_HUMAN
NC score	0.050517 (rank : 451)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	293	Target Neighborhood Hits	848	Shared Neighborhood Hits	41
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ZN185_MOUSE
NC score	0.050466 (rank : 452)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	293	Target Neighborhood Hits	89	Shared Neighborhood Hits	33
SwissProt Accessions	Q62394	Gene names	Znf185, Zfp185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein Zfp185) (P1-A).

MPP6_MOUSE
NC score	0.050155 (rank : 453)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	293	Target Neighborhood Hits	187	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

KPCA_HUMAN
NC score	0.024199 (rank : 454)	θ value	6.88961 (rank : 287)
Query Neighborhood Hits	293	Target Neighborhood Hits	1070	Shared Neighborhood Hits	49
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

VPS72_MOUSE
NC score	0.020088 (rank : 455)	θ value	1.81305 (rank : 270)
Query Neighborhood Hits	293	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

DLG5_HUMAN
NC score	0.019920 (rank : 456)	θ value	8.99809 (rank : 293)
Query Neighborhood Hits	293	Target Neighborhood Hits	1088	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

VPS72_HUMAN
NC score	0.019244 (rank : 457)	θ value	3.0926 (rank : 281)
Query Neighborhood Hits	293	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

ATS20_MOUSE
NC score	0.009323 (rank : 458)	θ value	0.21417 (rank : 221)
Query Neighborhood Hits	293	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

CACB2_MOUSE
NC score	0.009050 (rank : 459)	θ value	3.0926 (rank : 277)
Query Neighborhood Hits	293	Target Neighborhood Hits	94	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

UACA_HUMAN
NC score	0.008096 (rank : 460)	θ value	4.03905 (rank : 282)
Query Neighborhood Hits	293	Target Neighborhood Hits	1622	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

CJ006_MOUSE
NC score	0.006275 (rank : 461)	θ value	8.99809 (rank : 292)
Query Neighborhood Hits	293	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

K1C14_MOUSE
NC score	0.003475 (rank : 462)	θ value	1.06291 (rank : 256)
Query Neighborhood Hits	293	Target Neighborhood Hits	501	Shared Neighborhood Hits	13
SwissProt Accessions	Q61781, Q91VQ4	Gene names	Krt14, Krt1-14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

K1C14_HUMAN
NC score	0.003164 (rank : 463)	θ value	1.06291 (rank : 255)
Query Neighborhood Hits	293	Target Neighborhood Hits	491	Shared Neighborhood Hits	11
SwissProt Accessions	P02533, Q14715, Q53XY3, Q9BUE3, Q9UBN2, Q9UBN3, Q9UCY4	Gene names	KRT14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

COBA2_MOUSE
NC score	0.003089 (rank : 464)	θ value	2.36792 (rank : 271)
Query Neighborhood Hits	293	Target Neighborhood Hits	501	Shared Neighborhood Hits	9
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.