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Network neighborhood for query Sequence : P85A_HUMAN

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P85A_HUMAN
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

P55G_HUMAN
θ value	0 (rank : 1)	NC score	0.854723 (rank : 5)
Query Neighborhood Hits	479	Target Neighborhood Hits	451	Shared Neighborhood Hits	268
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	0 (rank : 2)	NC score	0.854341 (rank : 6)
Query Neighborhood Hits	479	Target Neighborhood Hits	401	Shared Neighborhood Hits	249
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	479	Target Neighborhood Hits	479	Shared Neighborhood Hits	479
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	0 (rank : 4)	NC score	0.991345 (rank : 2)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	408
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	0 (rank : 5)	NC score	0.870841 (rank : 3)
Query Neighborhood Hits	479	Target Neighborhood Hits	543	Shared Neighborhood Hits	302
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	0 (rank : 6)	NC score	0.865028 (rank : 4)
Query Neighborhood Hits	479	Target Neighborhood Hits	519	Shared Neighborhood Hits	304
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

MYO9B_HUMAN
θ value	1.2105e-12 (rank : 7)	NC score	0.252558 (rank : 119)
Query Neighborhood Hits	479	Target Neighborhood Hits	641	Shared Neighborhood Hits	111
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CHIN_MOUSE
θ value	2.0648e-12 (rank : 8)	NC score	0.501236 (rank : 7)
Query Neighborhood Hits	479	Target Neighborhood Hits	229	Shared Neighborhood Hits	147
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_MOUSE
θ value	2.0648e-12 (rank : 9)	NC score	0.413778 (rank : 32)
Query Neighborhood Hits	479	Target Neighborhood Hits	130	Shared Neighborhood Hits	67
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

MYO9B_MOUSE
θ value	2.69671e-12 (rank : 10)	NC score	0.254475 (rank : 115)
Query Neighborhood Hits	479	Target Neighborhood Hits	311	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CHIN_HUMAN
θ value	3.52202e-12 (rank : 11)	NC score	0.489112 (rank : 8)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	138
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	4.59992e-12 (rank : 12)	NC score	0.483749 (rank : 9)
Query Neighborhood Hits	479	Target Neighborhood Hits	220	Shared Neighborhood Hits	132
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RHG09_HUMAN
θ value	1.133e-10 (rank : 13)	NC score	0.442862 (rank : 14)
Query Neighborhood Hits	479	Target Neighborhood Hits	186	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

GMIP_HUMAN
θ value	9.59137e-10 (rank : 14)	NC score	0.438566 (rank : 16)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

VAV3_MOUSE
θ value	9.59137e-10 (rank : 15)	NC score	0.409881 (rank : 36)
Query Neighborhood Hits	479	Target Neighborhood Hits	404	Shared Neighborhood Hits	175
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GMIP_MOUSE
θ value	1.25267e-09 (rank : 16)	NC score	0.436661 (rank : 19)
Query Neighborhood Hits	479	Target Neighborhood Hits	202	Shared Neighborhood Hits	81
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRLF1_HUMAN
θ value	2.13673e-09 (rank : 17)	NC score	0.388942 (rank : 54)
Query Neighborhood Hits	479	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

TCGAP_MOUSE
θ value	8.11959e-09 (rank : 18)	NC score	0.420728 (rank : 23)
Query Neighborhood Hits	479	Target Neighborhood Hits	409	Shared Neighborhood Hits	115
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SOCS2_MOUSE
θ value	1.38499e-08 (rank : 19)	NC score	0.468081 (rank : 11)
Query Neighborhood Hits	479	Target Neighborhood Hits	94	Shared Neighborhood Hits	82
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

VAV3_HUMAN
θ value	1.38499e-08 (rank : 20)	NC score	0.405253 (rank : 40)
Query Neighborhood Hits	479	Target Neighborhood Hits	398	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

BCR_HUMAN
θ value	1.80886e-08 (rank : 21)	NC score	0.375376 (rank : 70)
Query Neighborhood Hits	479	Target Neighborhood Hits	204	Shared Neighborhood Hits	73
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

DAPP1_MOUSE
θ value	2.36244e-08 (rank : 22)	NC score	0.472613 (rank : 10)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SOCS2_HUMAN
θ value	2.36244e-08 (rank : 23)	NC score	0.461192 (rank : 12)
Query Neighborhood Hits	479	Target Neighborhood Hits	104	Shared Neighborhood Hits	82
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

TCGAP_HUMAN
θ value	3.08544e-08 (rank : 24)	NC score	0.368231 (rank : 74)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	123
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG25_MOUSE
θ value	4.0297e-08 (rank : 25)	NC score	0.391975 (rank : 51)
Query Neighborhood Hits	479	Target Neighborhood Hits	492	Shared Neighborhood Hits	168
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

ABR_HUMAN
θ value	5.26297e-08 (rank : 26)	NC score	0.398611 (rank : 43)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG12_HUMAN
θ value	6.87365e-08 (rank : 27)	NC score	0.420703 (rank : 24)
Query Neighborhood Hits	479	Target Neighborhood Hits	190	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	6.87365e-08 (rank : 28)	NC score	0.419763 (rank : 26)
Query Neighborhood Hits	479	Target Neighborhood Hits	204	Shared Neighborhood Hits	94
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG05_HUMAN
θ value	8.97725e-08 (rank : 29)	NC score	0.379721 (rank : 66)
Query Neighborhood Hits	479	Target Neighborhood Hits	158	Shared Neighborhood Hits	77
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

VAV_HUMAN
θ value	8.97725e-08 (rank : 30)	NC score	0.377540 (rank : 68)
Query Neighborhood Hits	479	Target Neighborhood Hits	452	Shared Neighborhood Hits	182
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

BTK_MOUSE
θ value	1.17247e-07 (rank : 31)	NC score	0.209832 (rank : 148)
Query Neighborhood Hits	479	Target Neighborhood Hits	1017	Shared Neighborhood Hits	163
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RHG25_HUMAN
θ value	1.17247e-07 (rank : 32)	NC score	0.388882 (rank : 55)
Query Neighborhood Hits	479	Target Neighborhood Hits	550	Shared Neighborhood Hits	199
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PLCG2_HUMAN
θ value	1.53129e-07 (rank : 33)	NC score	0.407178 (rank : 37)
Query Neighborhood Hits	479	Target Neighborhood Hits	280	Shared Neighborhood Hits	160
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

BTK_HUMAN
θ value	1.99992e-07 (rank : 34)	NC score	0.210315 (rank : 147)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	167
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SOCS6_HUMAN
θ value	1.99992e-07 (rank : 35)	NC score	0.431614 (rank : 21)
Query Neighborhood Hits	479	Target Neighborhood Hits	126	Shared Neighborhood Hits	84
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	1.99992e-07 (rank : 36)	NC score	0.432129 (rank : 20)
Query Neighborhood Hits	479	Target Neighborhood Hits	146	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

CEND2_HUMAN
θ value	3.41135e-07 (rank : 37)	NC score	0.316971 (rank : 96)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RBP1_HUMAN
θ value	3.41135e-07 (rank : 38)	NC score	0.386603 (rank : 57)
Query Neighborhood Hits	479	Target Neighborhood Hits	521	Shared Neighborhood Hits	198
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG05_MOUSE
θ value	3.41135e-07 (rank : 39)	NC score	0.382709 (rank : 60)
Query Neighborhood Hits	479	Target Neighborhood Hits	165	Shared Neighborhood Hits	82
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

VAV_MOUSE
θ value	3.41135e-07 (rank : 40)	NC score	0.366288 (rank : 76)
Query Neighborhood Hits	479	Target Neighborhood Hits	430	Shared Neighborhood Hits	173
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ABL2_HUMAN
θ value	4.45536e-07 (rank : 41)	NC score	0.206197 (rank : 155)
Query Neighborhood Hits	479	Target Neighborhood Hits	1045	Shared Neighborhood Hits	160
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

MATK_HUMAN
θ value	5.81887e-07 (rank : 42)	NC score	0.193999 (rank : 178)
Query Neighborhood Hits	479	Target Neighborhood Hits	954	Shared Neighborhood Hits	139
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	5.81887e-07 (rank : 43)	NC score	0.194388 (rank : 176)
Query Neighborhood Hits	479	Target Neighborhood Hits	952	Shared Neighborhood Hits	140
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

VAV2_HUMAN
θ value	5.81887e-07 (rank : 44)	NC score	0.379911 (rank : 64)
Query Neighborhood Hits	479	Target Neighborhood Hits	453	Shared Neighborhood Hits	189
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PTK6_HUMAN
θ value	9.92553e-07 (rank : 45)	NC score	0.180971 (rank : 207)
Query Neighborhood Hits	479	Target Neighborhood Hits	1020	Shared Neighborhood Hits	158
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RHG08_HUMAN
θ value	9.92553e-07 (rank : 46)	NC score	0.362797 (rank : 81)
Query Neighborhood Hits	479	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

BMX_HUMAN
θ value	1.29631e-06 (rank : 47)	NC score	0.180802 (rank : 208)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	114
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

RHG08_MOUSE
θ value	1.29631e-06 (rank : 48)	NC score	0.365595 (rank : 78)
Query Neighborhood Hits	479	Target Neighborhood Hits	73	Shared Neighborhood Hits	58
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

TXK_HUMAN
θ value	1.29631e-06 (rank : 49)	NC score	0.191396 (rank : 184)
Query Neighborhood Hits	479	Target Neighborhood Hits	971	Shared Neighborhood Hits	155
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

VAV2_MOUSE
θ value	1.29631e-06 (rank : 50)	NC score	0.377017 (rank : 69)
Query Neighborhood Hits	479	Target Neighborhood Hits	456	Shared Neighborhood Hits	182
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CEND1_MOUSE
θ value	2.21117e-06 (rank : 51)	NC score	0.274647 (rank : 104)
Query Neighborhood Hits	479	Target Neighborhood Hits	260	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CSK_HUMAN
θ value	2.21117e-06 (rank : 52)	NC score	0.200637 (rank : 167)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	171
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

DAPP1_HUMAN
θ value	2.21117e-06 (rank : 53)	NC score	0.455929 (rank : 13)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RGAP1_MOUSE
θ value	2.21117e-06 (rank : 54)	NC score	0.395640 (rank : 47)
Query Neighborhood Hits	479	Target Neighborhood Hits	185	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

ABL1_HUMAN
θ value	2.88788e-06 (rank : 55)	NC score	0.201575 (rank : 165)
Query Neighborhood Hits	479	Target Neighborhood Hits	1220	Shared Neighborhood Hits	166
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	2.88788e-06 (rank : 56)	NC score	0.201117 (rank : 166)
Query Neighborhood Hits	479	Target Neighborhood Hits	1178	Shared Neighborhood Hits	166
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

PLCG1_HUMAN
θ value	2.88788e-06 (rank : 57)	NC score	0.398125 (rank : 44)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	173
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	2.88788e-06 (rank : 58)	NC score	0.397076 (rank : 46)
Query Neighborhood Hits	479	Target Neighborhood Hits	314	Shared Neighborhood Hits	176
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CE005_MOUSE
θ value	3.77169e-06 (rank : 59)	NC score	0.318712 (rank : 95)
Query Neighborhood Hits	479	Target Neighborhood Hits	238	Shared Neighborhood Hits	99
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CSK_MOUSE
θ value	3.77169e-06 (rank : 60)	NC score	0.200260 (rank : 169)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	171
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PTK6_MOUSE
θ value	3.77169e-06 (rank : 61)	NC score	0.184961 (rank : 199)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	159
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

CEND1_HUMAN
θ value	6.43352e-06 (rank : 62)	NC score	0.264315 (rank : 111)
Query Neighborhood Hits	479	Target Neighborhood Hits	284	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

OPHN1_HUMAN
θ value	6.43352e-06 (rank : 63)	NC score	0.366182 (rank : 77)
Query Neighborhood Hits	479	Target Neighborhood Hits	161	Shared Neighborhood Hits	84
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	6.43352e-06 (rank : 64)	NC score	0.364619 (rank : 79)
Query Neighborhood Hits	479	Target Neighborhood Hits	174	Shared Neighborhood Hits	87
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RBP1_MOUSE
θ value	6.43352e-06 (rank : 65)	NC score	0.383267 (rank : 59)
Query Neighborhood Hits	479	Target Neighborhood Hits	493	Shared Neighborhood Hits	185
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

BMX_MOUSE
θ value	8.40245e-06 (rank : 66)	NC score	0.178766 (rank : 210)
Query Neighborhood Hits	479	Target Neighborhood Hits	912	Shared Neighborhood Hits	110
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CE005_HUMAN
θ value	8.40245e-06 (rank : 67)	NC score	0.323921 (rank : 93)
Query Neighborhood Hits	479	Target Neighborhood Hits	213	Shared Neighborhood Hits	114
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

TEC_HUMAN
θ value	8.40245e-06 (rank : 68)	NC score	0.191870 (rank : 183)
Query Neighborhood Hits	479	Target Neighborhood Hits	1006	Shared Neighborhood Hits	155
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SOCS7_MOUSE
θ value	1.09739e-05 (rank : 69)	NC score	0.413855 (rank : 30)
Query Neighborhood Hits	479	Target Neighborhood Hits	154	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SHB_HUMAN
θ value	1.43324e-05 (rank : 70)	NC score	0.394052 (rank : 49)
Query Neighborhood Hits	479	Target Neighborhood Hits	141	Shared Neighborhood Hits	112
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	1.43324e-05 (rank : 71)	NC score	0.393736 (rank : 50)
Query Neighborhood Hits	479	Target Neighborhood Hits	137	Shared Neighborhood Hits	111
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CISH_HUMAN
θ value	1.87187e-05 (rank : 72)	NC score	0.419786 (rank : 25)
Query Neighborhood Hits	479	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	1.87187e-05 (rank : 73)	NC score	0.415558 (rank : 27)
Query Neighborhood Hits	479	Target Neighborhood Hits	94	Shared Neighborhood Hits	82
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

FGR_HUMAN
θ value	1.87187e-05 (rank : 74)	NC score	0.222287 (rank : 136)
Query Neighborhood Hits	479	Target Neighborhood Hits	1067	Shared Neighborhood Hits	190
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ITSN1_HUMAN
θ value	1.87187e-05 (rank : 75)	NC score	0.240920 (rank : 125)
Query Neighborhood Hits	479	Target Neighborhood Hits	1757	Shared Neighborhood Hits	330
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

TEC_MOUSE
θ value	1.87187e-05 (rank : 76)	NC score	0.187433 (rank : 195)
Query Neighborhood Hits	479	Target Neighborhood Hits	1006	Shared Neighborhood Hits	152
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FER_HUMAN
θ value	2.44474e-05 (rank : 77)	NC score	0.190840 (rank : 186)
Query Neighborhood Hits	479	Target Neighborhood Hits	1278	Shared Neighborhood Hits	259
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGR_MOUSE
θ value	2.44474e-05 (rank : 78)	NC score	0.225684 (rank : 134)
Query Neighborhood Hits	479	Target Neighborhood Hits	1069	Shared Neighborhood Hits	193
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RHG26_HUMAN
θ value	2.44474e-05 (rank : 79)	NC score	0.413842 (rank : 31)
Query Neighborhood Hits	479	Target Neighborhood Hits	281	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SHC3_HUMAN
θ value	2.44474e-05 (rank : 80)	NC score	0.349281 (rank : 86)
Query Neighborhood Hits	479	Target Neighborhood Hits	155	Shared Neighborhood Hits	101
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

TAGAP_HUMAN
θ value	2.44474e-05 (rank : 81)	NC score	0.333822 (rank : 91)
Query Neighborhood Hits	479	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

3BP1_HUMAN
θ value	3.19293e-05 (rank : 82)	NC score	0.373968 (rank : 71)
Query Neighborhood Hits	479	Target Neighborhood Hits	376	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

DESP_HUMAN
θ value	3.19293e-05 (rank : 83)	NC score	0.163004 (rank : 227)
Query Neighborhood Hits	479	Target Neighborhood Hits	1470	Shared Neighborhood Hits	247
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

HCK_HUMAN
θ value	3.19293e-05 (rank : 84)	NC score	0.199091 (rank : 173)
Query Neighborhood Hits	479	Target Neighborhood Hits	1035	Shared Neighborhood Hits	172
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

I5P2_HUMAN
θ value	3.19293e-05 (rank : 85)	NC score	0.203187 (rank : 163)
Query Neighborhood Hits	479	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

SHC3_MOUSE
θ value	4.1701e-05 (rank : 86)	NC score	0.351511 (rank : 83)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	107
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

FRK_HUMAN
θ value	5.44631e-05 (rank : 87)	NC score	0.200310 (rank : 168)
Query Neighborhood Hits	479	Target Neighborhood Hits	1058	Shared Neighborhood Hits	177
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

RGAP1_HUMAN
θ value	5.44631e-05 (rank : 88)	NC score	0.405583 (rank : 39)
Query Neighborhood Hits	479	Target Neighborhood Hits	189	Shared Neighborhood Hits	102
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

SHE_MOUSE
θ value	7.1131e-05 (rank : 89)	NC score	0.410216 (rank : 35)
Query Neighborhood Hits	479	Target Neighborhood Hits	169	Shared Neighborhood Hits	119
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

FYN_MOUSE
θ value	9.29e-05 (rank : 90)	NC score	0.213215 (rank : 144)
Query Neighborhood Hits	479	Target Neighborhood Hits	1073	Shared Neighborhood Hits	186
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ITSN1_MOUSE
θ value	9.29e-05 (rank : 91)	NC score	0.238087 (rank : 126)
Query Neighborhood Hits	479	Target Neighborhood Hits	1669	Shared Neighborhood Hits	318
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SHE_HUMAN
θ value	9.29e-05 (rank : 92)	NC score	0.410510 (rank : 34)
Query Neighborhood Hits	479	Target Neighborhood Hits	164	Shared Neighborhood Hits	112
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

FYN_HUMAN
θ value	0.000121331 (rank : 93)	NC score	0.210855 (rank : 146)
Query Neighborhood Hits	479	Target Neighborhood Hits	1078	Shared Neighborhood Hits	190
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

KSYK_HUMAN
θ value	0.000121331 (rank : 94)	NC score	0.166404 (rank : 223)
Query Neighborhood Hits	479	Target Neighborhood Hits	901	Shared Neighborhood Hits	117
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SHC2_HUMAN
θ value	0.000121331 (rank : 95)	NC score	0.285629 (rank : 102)
Query Neighborhood Hits	479	Target Neighborhood Hits	170	Shared Neighborhood Hits	111
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	0.000121331 (rank : 96)	NC score	0.289027 (rank : 100)
Query Neighborhood Hits	479	Target Neighborhood Hits	144	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHD_MOUSE
θ value	0.000121331 (rank : 97)	NC score	0.391146 (rank : 53)
Query Neighborhood Hits	479	Target Neighborhood Hits	137	Shared Neighborhood Hits	108
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SOCS3_HUMAN
θ value	0.000121331 (rank : 98)	NC score	0.366975 (rank : 75)
Query Neighborhood Hits	479	Target Neighborhood Hits	77	Shared Neighborhood Hits	65
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	0.000121331 (rank : 99)	NC score	0.364301 (rank : 80)
Query Neighborhood Hits	479	Target Neighborhood Hits	72	Shared Neighborhood Hits	65
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

HCK_MOUSE
θ value	0.000158464 (rank : 100)	NC score	0.200117 (rank : 170)
Query Neighborhood Hits	479	Target Neighborhood Hits	1029	Shared Neighborhood Hits	168
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KSYK_MOUSE
θ value	0.000158464 (rank : 101)	NC score	0.166772 (rank : 222)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	119
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NCK2_HUMAN
θ value	0.000158464 (rank : 102)	NC score	0.440637 (rank : 15)
Query Neighborhood Hits	479	Target Neighborhood Hits	310	Shared Neighborhood Hits	182
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRB2_HUMAN
θ value	0.00020696 (rank : 103)	NC score	0.436918 (rank : 18)
Query Neighborhood Hits	479	Target Neighborhood Hits	310	Shared Neighborhood Hits	168
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00020696 (rank : 104)	NC score	0.437456 (rank : 17)
Query Neighborhood Hits	479	Target Neighborhood Hits	312	Shared Neighborhood Hits	170
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

OCRL_HUMAN
θ value	0.00020696 (rank : 105)	NC score	0.199835 (rank : 171)
Query Neighborhood Hits	479	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

TAGAP_MOUSE
θ value	0.00020696 (rank : 106)	NC score	0.332496 (rank : 92)
Query Neighborhood Hits	479	Target Neighborhood Hits	83	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TXK_MOUSE
θ value	0.00020696 (rank : 107)	NC score	0.188621 (rank : 191)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	168
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CEND3_MOUSE
θ value	0.000270298 (rank : 108)	NC score	0.281422 (rank : 103)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CRKL_HUMAN
θ value	0.000270298 (rank : 109)	NC score	0.415533 (rank : 28)
Query Neighborhood Hits	479	Target Neighborhood Hits	313	Shared Neighborhood Hits	171
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

LYN_MOUSE
θ value	0.000270298 (rank : 110)	NC score	0.189890 (rank : 189)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	163
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CRKL_MOUSE
θ value	0.00035302 (rank : 111)	NC score	0.414264 (rank : 29)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	169
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ITK_HUMAN
θ value	0.00035302 (rank : 112)	NC score	0.184470 (rank : 202)
Query Neighborhood Hits	479	Target Neighborhood Hits	1016	Shared Neighborhood Hits	150
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

CRK_HUMAN
θ value	0.000461057 (rank : 113)	NC score	0.405663 (rank : 38)
Query Neighborhood Hits	479	Target Neighborhood Hits	308	Shared Neighborhood Hits	171
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.000461057 (rank : 114)	NC score	0.403484 (rank : 41)
Query Neighborhood Hits	479	Target Neighborhood Hits	314	Shared Neighborhood Hits	171
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ITK_MOUSE
θ value	0.000602161 (rank : 115)	NC score	0.181018 (rank : 206)
Query Neighborhood Hits	479	Target Neighborhood Hits	985	Shared Neighborhood Hits	142
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LYN_HUMAN
θ value	0.000602161 (rank : 116)	NC score	0.188201 (rank : 192)
Query Neighborhood Hits	479	Target Neighborhood Hits	1022	Shared Neighborhood Hits	163
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYO7A_MOUSE
θ value	0.000602161 (rank : 117)	NC score	0.086301 (rank : 839)
Query Neighborhood Hits	479	Target Neighborhood Hits	235	Shared Neighborhood Hits	63
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

RHG01_HUMAN
θ value	0.000602161 (rank : 118)	NC score	0.351444 (rank : 84)
Query Neighborhood Hits	479	Target Neighborhood Hits	75	Shared Neighborhood Hits	58
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG06_HUMAN
θ value	0.000602161 (rank : 119)	NC score	0.350449 (rank : 85)
Query Neighborhood Hits	479	Target Neighborhood Hits	114	Shared Neighborhood Hits	61
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SHC1_MOUSE
θ value	0.000602161 (rank : 120)	NC score	0.303459 (rank : 98)
Query Neighborhood Hits	479	Target Neighborhood Hits	180	Shared Neighborhood Hits	112
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SLAP2_MOUSE
θ value	0.000602161 (rank : 121)	NC score	0.400213 (rank : 42)
Query Neighborhood Hits	479	Target Neighborhood Hits	136	Shared Neighborhood Hits	110
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

YES_HUMAN
θ value	0.000602161 (rank : 122)	NC score	0.208698 (rank : 153)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	172
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.000602161 (rank : 123)	NC score	0.209211 (rank : 152)
Query Neighborhood Hits	479	Target Neighborhood Hits	1052	Shared Neighborhood Hits	173
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

3BP1_MOUSE
θ value	0.000786445 (rank : 124)	NC score	0.368990 (rank : 73)
Query Neighborhood Hits	479	Target Neighborhood Hits	238	Shared Neighborhood Hits	71
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CP135_MOUSE
θ value	0.000786445 (rank : 125)	NC score	0.152516 (rank : 263)
Query Neighborhood Hits	479	Target Neighborhood Hits	1278	Shared Neighborhood Hits	241
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

PHLB2_MOUSE
θ value	0.00102713 (rank : 126)	NC score	0.129853 (rank : 366)
Query Neighborhood Hits	479	Target Neighborhood Hits	1016	Shared Neighborhood Hits	205
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RHG18_HUMAN
θ value	0.00102713 (rank : 127)	NC score	0.319128 (rank : 94)
Query Neighborhood Hits	479	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

SLAP1_MOUSE
θ value	0.00102713 (rank : 128)	NC score	0.380645 (rank : 63)
Query Neighborhood Hits	479	Target Neighborhood Hits	117	Shared Neighborhood Hits	92
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

PPIP1_MOUSE
θ value	0.00175202 (rank : 129)	NC score	0.252816 (rank : 118)
Query Neighborhood Hits	479	Target Neighborhood Hits	377	Shared Neighborhood Hits	177
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTN6_MOUSE
θ value	0.00175202 (rank : 130)	NC score	0.184495 (rank : 201)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	118
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	0.00175202 (rank : 131)	NC score	0.337364 (rank : 90)
Query Neighborhood Hits	479	Target Neighborhood Hits	258	Shared Neighborhood Hits	129
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG06_MOUSE
θ value	0.00175202 (rank : 132)	NC score	0.346551 (rank : 87)
Query Neighborhood Hits	479	Target Neighborhood Hits	105	Shared Neighborhood Hits	59
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SOCS1_MOUSE
θ value	0.00175202 (rank : 133)	NC score	0.357507 (rank : 82)
Query Neighborhood Hits	479	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SRC_HUMAN
θ value	0.00175202 (rank : 134)	NC score	0.209383 (rank : 151)
Query Neighborhood Hits	479	Target Neighborhood Hits	1058	Shared Neighborhood Hits	183
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.00175202 (rank : 135)	NC score	0.205084 (rank : 159)
Query Neighborhood Hits	479	Target Neighborhood Hits	1033	Shared Neighborhood Hits	179
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

MYH3_HUMAN
θ value	0.00228821 (rank : 136)	NC score	0.135355 (rank : 319)
Query Neighborhood Hits	479	Target Neighborhood Hits	1660	Shared Neighborhood Hits	258
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

NEBL_HUMAN
θ value	0.00228821 (rank : 137)	NC score	0.219127 (rank : 138)
Query Neighborhood Hits	479	Target Neighborhood Hits	457	Shared Neighborhood Hits	185
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PPIP1_HUMAN
θ value	0.00228821 (rank : 138)	NC score	0.265324 (rank : 110)
Query Neighborhood Hits	479	Target Neighborhood Hits	389	Shared Neighborhood Hits	185
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SLAP1_HUMAN
θ value	0.00298849 (rank : 139)	NC score	0.372595 (rank : 72)
Query Neighborhood Hits	479	Target Neighborhood Hits	113	Shared Neighborhood Hits	93
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SRGP1_HUMAN
θ value	0.00298849 (rank : 140)	NC score	0.379861 (rank : 65)
Query Neighborhood Hits	479	Target Neighborhood Hits	390	Shared Neighborhood Hits	194
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

CEND3_HUMAN
θ value	0.00390308 (rank : 141)	NC score	0.273397 (rank : 106)
Query Neighborhood Hits	479	Target Neighborhood Hits	275	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

GRAP2_MOUSE
θ value	0.00390308 (rank : 142)	NC score	0.395408 (rank : 48)
Query Neighborhood Hits	479	Target Neighborhood Hits	297	Shared Neighborhood Hits	157
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_MOUSE
θ value	0.00390308 (rank : 143)	NC score	0.421225 (rank : 22)
Query Neighborhood Hits	479	Target Neighborhood Hits	309	Shared Neighborhood Hits	160
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

KMHN1_HUMAN
θ value	0.00390308 (rank : 144)	NC score	0.152503 (rank : 264)
Query Neighborhood Hits	479	Target Neighborhood Hits	950	Shared Neighborhood Hits	213
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

SHD_HUMAN
θ value	0.00390308 (rank : 145)	NC score	0.346097 (rank : 88)
Query Neighborhood Hits	479	Target Neighborhood Hits	204	Shared Neighborhood Hits	106
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

BI2L1_MOUSE
θ value	0.00509761 (rank : 146)	NC score	0.108200 (rank : 535)
Query Neighborhood Hits	479	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

LCK_HUMAN
θ value	0.00509761 (rank : 147)	NC score	0.187746 (rank : 193)
Query Neighborhood Hits	479	Target Neighborhood Hits	987	Shared Neighborhood Hits	147
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

RHG04_HUMAN
θ value	0.00509761 (rank : 148)	NC score	0.397834 (rank : 45)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	160
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SM1L2_MOUSE
θ value	0.00509761 (rank : 149)	NC score	0.152481 (rank : 265)
Query Neighborhood Hits	479	Target Neighborhood Hits	918	Shared Neighborhood Hits	221
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SOCS1_HUMAN
θ value	0.00509761 (rank : 150)	NC score	0.344937 (rank : 89)
Query Neighborhood Hits	479	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS5_HUMAN
θ value	0.00509761 (rank : 151)	NC score	0.263039 (rank : 112)
Query Neighborhood Hits	479	Target Neighborhood Hits	91	Shared Neighborhood Hits	72
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	0.00509761 (rank : 152)	NC score	0.262166 (rank : 113)
Query Neighborhood Hits	479	Target Neighborhood Hits	93	Shared Neighborhood Hits	71
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SRGP2_HUMAN
θ value	0.00509761 (rank : 153)	NC score	0.386707 (rank : 56)
Query Neighborhood Hits	479	Target Neighborhood Hits	331	Shared Neighborhood Hits	174
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

TUFT1_MOUSE
θ value	0.00665767 (rank : 154)	NC score	0.129284 (rank : 372)
Query Neighborhood Hits	479	Target Neighborhood Hits	732	Shared Neighborhood Hits	184
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

CTRO_HUMAN
θ value	0.00869519 (rank : 155)	NC score	0.117365 (rank : 454)
Query Neighborhood Hits	479	Target Neighborhood Hits	2092	Shared Neighborhood Hits	283
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

HOOK3_HUMAN
θ value	0.00869519 (rank : 156)	NC score	0.145697 (rank : 286)
Query Neighborhood Hits	479	Target Neighborhood Hits	1070	Shared Neighborhood Hits	234
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

LASP1_HUMAN
θ value	0.00869519 (rank : 157)	NC score	0.187548 (rank : 194)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	102
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00869519 (rank : 158)	NC score	0.185850 (rank : 196)
Query Neighborhood Hits	479	Target Neighborhood Hits	297	Shared Neighborhood Hits	100
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PTN11_HUMAN
θ value	0.00869519 (rank : 159)	NC score	0.204845 (rank : 161)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	121
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.00869519 (rank : 160)	NC score	0.204862 (rank : 160)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	121
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

SH3K1_HUMAN
θ value	0.00869519 (rank : 161)	NC score	0.204005 (rank : 162)
Query Neighborhood Hits	479	Target Neighborhood Hits	341	Shared Neighborhood Hits	127
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CTRO_MOUSE
θ value	0.0113563 (rank : 162)	NC score	0.119534 (rank : 438)
Query Neighborhood Hits	479	Target Neighborhood Hits	2344	Shared Neighborhood Hits	295
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

HOOK3_MOUSE
θ value	0.0113563 (rank : 163)	NC score	0.143482 (rank : 298)
Query Neighborhood Hits	479	Target Neighborhood Hits	1007	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

LCK_MOUSE
θ value	0.0113563 (rank : 164)	NC score	0.184985 (rank : 198)
Query Neighborhood Hits	479	Target Neighborhood Hits	981	Shared Neighborhood Hits	149
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SH24A_MOUSE
θ value	0.0113563 (rank : 165)	NC score	0.268854 (rank : 108)
Query Neighborhood Hits	479	Target Neighborhood Hits	326	Shared Neighborhood Hits	126
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

BPA1_MOUSE
θ value	0.0148317 (rank : 166)	NC score	0.110019 (rank : 515)
Query Neighborhood Hits	479	Target Neighborhood Hits	1477	Shared Neighborhood Hits	228
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

FNBP2_HUMAN
θ value	0.0148317 (rank : 167)	NC score	0.385932 (rank : 58)
Query Neighborhood Hits	479	Target Neighborhood Hits	432	Shared Neighborhood Hits	210
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRAP2_HUMAN
θ value	0.0148317 (rank : 168)	NC score	0.391317 (rank : 52)
Query Neighborhood Hits	479	Target Neighborhood Hits	304	Shared Neighborhood Hits	157
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PACN1_MOUSE
θ value	0.0148317 (rank : 169)	NC score	0.202224 (rank : 164)
Query Neighborhood Hits	479	Target Neighborhood Hits	283	Shared Neighborhood Hits	139
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

TACC2_HUMAN
θ value	0.0148317 (rank : 170)	NC score	0.144949 (rank : 289)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	178
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

CK5P2_HUMAN
θ value	0.0193708 (rank : 171)	NC score	0.150038 (rank : 273)
Query Neighborhood Hits	479	Target Neighborhood Hits	1433	Shared Neighborhood Hits	242
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

RAD50_MOUSE
θ value	0.0193708 (rank : 172)	NC score	0.144380 (rank : 294)
Query Neighborhood Hits	479	Target Neighborhood Hits	1366	Shared Neighborhood Hits	235
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RHG07_MOUSE
θ value	0.0193708 (rank : 173)	NC score	0.274475 (rank : 105)
Query Neighborhood Hits	479	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

SLAP2_HUMAN
θ value	0.0193708 (rank : 174)	NC score	0.377984 (rank : 67)
Query Neighborhood Hits	479	Target Neighborhood Hits	139	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRAP_HUMAN
θ value	0.0252991 (rank : 175)	NC score	0.413240 (rank : 33)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	158
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

MYO7A_HUMAN
θ value	0.0252991 (rank : 176)	NC score	0.080179 (rank : 898)
Query Neighborhood Hits	479	Target Neighborhood Hits	209	Shared Neighborhood Hits	56
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

SRBS1_HUMAN
θ value	0.0252991 (rank : 177)	NC score	0.250003 (rank : 120)
Query Neighborhood Hits	479	Target Neighborhood Hits	396	Shared Neighborhood Hits	127
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAR8_HUMAN
θ value	0.0252991 (rank : 178)	NC score	0.253519 (rank : 117)
Query Neighborhood Hits	479	Target Neighborhood Hits	216	Shared Neighborhood Hits	63
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

ZAP70_MOUSE
θ value	0.0252991 (rank : 179)	NC score	0.155420 (rank : 250)
Query Neighborhood Hits	479	Target Neighborhood Hits	905	Shared Neighborhood Hits	119
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BLNK_HUMAN
θ value	0.0330416 (rank : 180)	NC score	0.214345 (rank : 143)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

HMMR_MOUSE
θ value	0.0330416 (rank : 181)	NC score	0.167530 (rank : 220)
Query Neighborhood Hits	479	Target Neighborhood Hits	1178	Shared Neighborhood Hits	240
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

MYH8_HUMAN
θ value	0.0330416 (rank : 182)	NC score	0.130071 (rank : 364)
Query Neighborhood Hits	479	Target Neighborhood Hits	1610	Shared Neighborhood Hits	259
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PACN1_HUMAN
θ value	0.0330416 (rank : 183)	NC score	0.206191 (rank : 156)
Query Neighborhood Hits	479	Target Neighborhood Hits	320	Shared Neighborhood Hits	162
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAR8_MOUSE
θ value	0.0330416 (rank : 184)	NC score	0.255984 (rank : 114)
Query Neighborhood Hits	479	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STK10_MOUSE
θ value	0.0330416 (rank : 185)	NC score	0.099645 (rank : 653)
Query Neighborhood Hits	479	Target Neighborhood Hits	2132	Shared Neighborhood Hits	257
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

VINEX_HUMAN
θ value	0.0330416 (rank : 186)	NC score	0.248098 (rank : 122)
Query Neighborhood Hits	479	Target Neighborhood Hits	270	Shared Neighborhood Hits	118
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	0.0330416 (rank : 187)	NC score	0.249467 (rank : 121)
Query Neighborhood Hits	479	Target Neighborhood Hits	286	Shared Neighborhood Hits	117
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZAP70_HUMAN
θ value	0.0330416 (rank : 188)	NC score	0.152988 (rank : 260)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	117
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SNX18_MOUSE
θ value	0.0431538 (rank : 189)	NC score	0.131435 (rank : 354)
Query Neighborhood Hits	479	Target Neighborhood Hits	198	Shared Neighborhood Hits	77
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SRGP2_MOUSE
θ value	0.0431538 (rank : 190)	NC score	0.381723 (rank : 61)
Query Neighborhood Hits	479	Target Neighborhood Hits	324	Shared Neighborhood Hits	176
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CI093_HUMAN
θ value	0.0563607 (rank : 191)	NC score	0.162511 (rank : 229)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	241
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

GOGA4_MOUSE
θ value	0.0563607 (rank : 192)	NC score	0.153050 (rank : 259)
Query Neighborhood Hits	479	Target Neighborhood Hits	1939	Shared Neighborhood Hits	258
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HSH2D_MOUSE
θ value	0.0563607 (rank : 193)	NC score	0.288017 (rank : 101)
Query Neighborhood Hits	479	Target Neighborhood Hits	124	Shared Neighborhood Hits	91
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

RHG07_HUMAN
θ value	0.0563607 (rank : 194)	NC score	0.269657 (rank : 107)
Query Neighborhood Hits	479	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

SOCS4_HUMAN
θ value	0.0563607 (rank : 195)	NC score	0.235306 (rank : 129)
Query Neighborhood Hits	479	Target Neighborhood Hits	69	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
θ value	0.0563607 (rank : 196)	NC score	0.236141 (rank : 127)
Query Neighborhood Hits	479	Target Neighborhood Hits	69	Shared Neighborhood Hits	55
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SRBS1_MOUSE
θ value	0.0563607 (rank : 197)	NC score	0.243960 (rank : 124)
Query Neighborhood Hits	479	Target Neighborhood Hits	409	Shared Neighborhood Hits	126
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CENPE_HUMAN
θ value	0.0736092 (rank : 198)	NC score	0.131919 (rank : 348)
Query Neighborhood Hits	479	Target Neighborhood Hits	2060	Shared Neighborhood Hits	270
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CI039_HUMAN
θ value	0.0736092 (rank : 199)	NC score	0.160139 (rank : 235)
Query Neighborhood Hits	479	Target Neighborhood Hits	1171	Shared Neighborhood Hits	220
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CN145_MOUSE
θ value	0.0736092 (rank : 200)	NC score	0.157635 (rank : 241)
Query Neighborhood Hits	479	Target Neighborhood Hits	916	Shared Neighborhood Hits	212
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

INCE_MOUSE
θ value	0.0736092 (rank : 201)	NC score	0.159657 (rank : 236)
Query Neighborhood Hits	479	Target Neighborhood Hits	903	Shared Neighborhood Hits	188
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

S6OS1_MOUSE
θ value	0.0736092 (rank : 202)	NC score	0.095578 (rank : 722)
Query Neighborhood Hits	479	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CTN5, Q9D5F5, Q9D5Y9	Gene names	Six6os1
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

SPTA1_MOUSE
θ value	0.0736092 (rank : 203)	NC score	0.148234 (rank : 278)
Query Neighborhood Hits	479	Target Neighborhood Hits	675	Shared Neighborhood Hits	246
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

BICD1_MOUSE
θ value	0.0961366 (rank : 204)	NC score	0.151731 (rank : 268)
Query Neighborhood Hits	479	Target Neighborhood Hits	837	Shared Neighborhood Hits	212
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CENPF_HUMAN
θ value	0.0961366 (rank : 205)	NC score	0.150512 (rank : 271)
Query Neighborhood Hits	479	Target Neighborhood Hits	1932	Shared Neighborhood Hits	270
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CN145_HUMAN
θ value	0.0961366 (rank : 206)	NC score	0.155730 (rank : 247)
Query Neighborhood Hits	479	Target Neighborhood Hits	1196	Shared Neighborhood Hits	241
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

MRCKB_MOUSE
θ value	0.0961366 (rank : 207)	NC score	0.113212 (rank : 485)
Query Neighborhood Hits	479	Target Neighborhood Hits	2180	Shared Neighborhood Hits	295
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MYH13_HUMAN
θ value	0.0961366 (rank : 208)	NC score	0.131140 (rank : 357)
Query Neighborhood Hits	479	Target Neighborhood Hits	1504	Shared Neighborhood Hits	248
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

SNX18_HUMAN
θ value	0.0961366 (rank : 209)	NC score	0.129461 (rank : 370)
Query Neighborhood Hits	479	Target Neighborhood Hits	207	Shared Neighborhood Hits	80
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

AHI1_MOUSE
θ value	0.125558 (rank : 210)	NC score	0.151866 (rank : 266)
Query Neighborhood Hits	479	Target Neighborhood Hits	496	Shared Neighborhood Hits	110
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AMRP_HUMAN
θ value	0.125558 (rank : 211)	NC score	0.090682 (rank : 784)
Query Neighborhood Hits	479	Target Neighborhood Hits	126	Shared Neighborhood Hits	55
SwissProt Accessions	P30533	Gene names	LRPAP1, A2MRAP
Domain Architecture
Description	Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2- MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP).

CP135_HUMAN
θ value	0.125558 (rank : 212)	NC score	0.150206 (rank : 272)
Query Neighborhood Hits	479	Target Neighborhood Hits	1290	Shared Neighborhood Hits	240
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CR034_MOUSE
θ value	0.125558 (rank : 213)	NC score	0.130376 (rank : 362)
Query Neighborhood Hits	479	Target Neighborhood Hits	643	Shared Neighborhood Hits	191
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

DZIP1_MOUSE
θ value	0.125558 (rank : 214)	NC score	0.159592 (rank : 237)
Query Neighborhood Hits	479	Target Neighborhood Hits	530	Shared Neighborhood Hits	124
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

GBP2_MOUSE
θ value	0.125558 (rank : 215)	NC score	0.069104 (rank : 1029)
Query Neighborhood Hits	479	Target Neighborhood Hits	323	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Z0E6, Q8CIC6, Q921N2, Q9R1I0	Gene names	Gbp2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (mGBP2) (mGBP-2).

SM1L2_HUMAN
θ value	0.125558 (rank : 216)	NC score	0.145121 (rank : 288)
Query Neighborhood Hits	479	Target Neighborhood Hits	1019	Shared Neighborhood Hits	219
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

BLK_HUMAN
θ value	0.163984 (rank : 217)	NC score	0.181575 (rank : 205)
Query Neighborhood Hits	479	Target Neighborhood Hits	994	Shared Neighborhood Hits	158
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DZIP1_HUMAN
θ value	0.163984 (rank : 218)	NC score	0.157782 (rank : 240)
Query Neighborhood Hits	479	Target Neighborhood Hits	675	Shared Neighborhood Hits	118
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

GCC2_HUMAN
θ value	0.163984 (rank : 219)	NC score	0.143789 (rank : 296)
Query Neighborhood Hits	479	Target Neighborhood Hits	1558	Shared Neighborhood Hits	252
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GOGB1_HUMAN
θ value	0.163984 (rank : 220)	NC score	0.154986 (rank : 252)
Query Neighborhood Hits	479	Target Neighborhood Hits	2297	Shared Neighborhood Hits	279
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

LCP2_HUMAN
θ value	0.163984 (rank : 221)	NC score	0.185811 (rank : 197)
Query Neighborhood Hits	479	Target Neighborhood Hits	531	Shared Neighborhood Hits	81
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PLCB1_MOUSE
θ value	0.163984 (rank : 222)	NC score	0.118744 (rank : 445)
Query Neighborhood Hits	479	Target Neighborhood Hits	531	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PTN6_HUMAN
θ value	0.163984 (rank : 223)	NC score	0.171310 (rank : 217)
Query Neighborhood Hits	479	Target Neighborhood Hits	234	Shared Neighborhood Hits	114
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

RBP24_HUMAN
θ value	0.163984 (rank : 224)	NC score	0.143408 (rank : 299)
Query Neighborhood Hits	479	Target Neighborhood Hits	1559	Shared Neighborhood Hits	254
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RUFY2_HUMAN
θ value	0.163984 (rank : 225)	NC score	0.113543 (rank : 483)
Query Neighborhood Hits	479	Target Neighborhood Hits	1208	Shared Neighborhood Hits	215
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

STAT1_MOUSE
θ value	0.163984 (rank : 226)	NC score	0.061057 (rank : 1135)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	P42225	Gene names	Stat1
Domain Architecture
Description	Signal transducer and activator of transcription 1.

AHI1_HUMAN
θ value	0.21417 (rank : 227)	NC score	0.155240 (rank : 251)
Query Neighborhood Hits	479	Target Neighborhood Hits	537	Shared Neighborhood Hits	123
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG5_HUMAN
θ value	0.21417 (rank : 228)	NC score	0.087684 (rank : 824)
Query Neighborhood Hits	479	Target Neighborhood Hits	172	Shared Neighborhood Hits	62
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

BLK_MOUSE
θ value	0.21417 (rank : 229)	NC score	0.184668 (rank : 200)
Query Neighborhood Hits	479	Target Neighborhood Hits	992	Shared Neighborhood Hits	162
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_MOUSE
θ value	0.21417 (rank : 230)	NC score	0.219173 (rank : 137)
Query Neighborhood Hits	479	Target Neighborhood Hits	296	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

ERC2_HUMAN
θ value	0.21417 (rank : 231)	NC score	0.153492 (rank : 258)
Query Neighborhood Hits	479	Target Neighborhood Hits	1156	Shared Neighborhood Hits	229
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	0.21417 (rank : 232)	NC score	0.153833 (rank : 255)
Query Neighborhood Hits	479	Target Neighborhood Hits	1166	Shared Neighborhood Hits	230
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ITSN2_MOUSE
θ value	0.21417 (rank : 233)	NC score	0.235898 (rank : 128)
Query Neighborhood Hits	479	Target Neighborhood Hits	1371	Shared Neighborhood Hits	312
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SNX23_HUMAN
θ value	0.21417 (rank : 234)	NC score	0.100122 (rank : 645)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	213
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

TEX9_HUMAN
θ value	0.21417 (rank : 235)	NC score	0.147976 (rank : 279)
Query Neighborhood Hits	479	Target Neighborhood Hits	541	Shared Neighborhood Hits	169
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

3BP2_MOUSE
θ value	0.279714 (rank : 236)	NC score	0.117296 (rank : 456)
Query Neighborhood Hits	479	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

BICD2_HUMAN
θ value	0.279714 (rank : 237)	NC score	0.131147 (rank : 356)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	198
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	0.279714 (rank : 238)	NC score	0.125052 (rank : 402)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	198
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

GOGA1_MOUSE
θ value	0.279714 (rank : 239)	NC score	0.133627 (rank : 330)
Query Neighborhood Hits	479	Target Neighborhood Hits	994	Shared Neighborhood Hits	223
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

KGP2_HUMAN
θ value	0.279714 (rank : 240)	NC score	0.052708 (rank : 1324)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	107
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KINH_HUMAN
θ value	0.279714 (rank : 241)	NC score	0.107167 (rank : 545)
Query Neighborhood Hits	479	Target Neighborhood Hits	1231	Shared Neighborhood Hits	233
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

LCP2_MOUSE
θ value	0.279714 (rank : 242)	NC score	0.234819 (rank : 130)
Query Neighborhood Hits	479	Target Neighborhood Hits	177	Shared Neighborhood Hits	72
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PACN3_HUMAN
θ value	0.279714 (rank : 243)	NC score	0.192779 (rank : 181)
Query Neighborhood Hits	479	Target Neighborhood Hits	385	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PIBF1_HUMAN
θ value	0.279714 (rank : 244)	NC score	0.136131 (rank : 316)
Query Neighborhood Hits	479	Target Neighborhood Hits	1041	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

RB6I2_HUMAN
θ value	0.279714 (rank : 245)	NC score	0.146737 (rank : 281)
Query Neighborhood Hits	479	Target Neighborhood Hits	1584	Shared Neighborhood Hits	244
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

SH24A_HUMAN
θ value	0.279714 (rank : 246)	NC score	0.254235 (rank : 116)
Query Neighborhood Hits	479	Target Neighborhood Hits	455	Shared Neighborhood Hits	183
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SYGP1_HUMAN
θ value	0.279714 (rank : 247)	NC score	0.075283 (rank : 950)
Query Neighborhood Hits	479	Target Neighborhood Hits	589	Shared Neighborhood Hits	152
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

UACA_MOUSE
θ value	0.279714 (rank : 248)	NC score	0.118627 (rank : 449)
Query Neighborhood Hits	479	Target Neighborhood Hits	1620	Shared Neighborhood Hits	239
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

ABI2_HUMAN
θ value	0.365318 (rank : 249)	NC score	0.175883 (rank : 214)
Query Neighborhood Hits	479	Target Neighborhood Hits	350	Shared Neighborhood Hits	105
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.365318 (rank : 250)	NC score	0.177239 (rank : 212)
Query Neighborhood Hits	479	Target Neighborhood Hits	266	Shared Neighborhood Hits	103
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ADIP_HUMAN
θ value	0.365318 (rank : 251)	NC score	0.122361 (rank : 421)
Query Neighborhood Hits	479	Target Neighborhood Hits	470	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

AKAP9_HUMAN
θ value	0.365318 (rank : 252)	NC score	0.154984 (rank : 253)
Query Neighborhood Hits	479	Target Neighborhood Hits	1710	Shared Neighborhood Hits	251
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BCAR3_MOUSE
θ value	0.365318 (rank : 253)	NC score	0.177886 (rank : 211)
Query Neighborhood Hits	479	Target Neighborhood Hits	127	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

DNMBP_HUMAN
θ value	0.365318 (rank : 254)	NC score	0.198632 (rank : 174)
Query Neighborhood Hits	479	Target Neighborhood Hits	413	Shared Neighborhood Hits	151
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ERCC6_HUMAN
θ value	0.365318 (rank : 255)	NC score	0.019518 (rank : 1447)
Query Neighborhood Hits	479	Target Neighborhood Hits	247	Shared Neighborhood Hits	41
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

ITSN2_HUMAN
θ value	0.365318 (rank : 256)	NC score	0.229233 (rank : 133)
Query Neighborhood Hits	479	Target Neighborhood Hits	1173	Shared Neighborhood Hits	289
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MYH10_HUMAN
θ value	0.365318 (rank : 257)	NC score	0.127727 (rank : 380)
Query Neighborhood Hits	479	Target Neighborhood Hits	1620	Shared Neighborhood Hits	249
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NAF1_MOUSE
θ value	0.365318 (rank : 258)	NC score	0.124412 (rank : 409)
Query Neighborhood Hits	479	Target Neighborhood Hits	852	Shared Neighborhood Hits	184
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

PACN3_MOUSE
θ value	0.365318 (rank : 259)	NC score	0.194285 (rank : 177)
Query Neighborhood Hits	479	Target Neighborhood Hits	380	Shared Neighborhood Hits	158
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

TACC2_MOUSE
θ value	0.365318 (rank : 260)	NC score	0.137470 (rank : 312)
Query Neighborhood Hits	479	Target Neighborhood Hits	774	Shared Neighborhood Hits	165
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

UACA_HUMAN
θ value	0.365318 (rank : 261)	NC score	0.112393 (rank : 491)
Query Neighborhood Hits	479	Target Neighborhood Hits	1622	Shared Neighborhood Hits	236
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

BICD1_HUMAN
θ value	0.47712 (rank : 262)	NC score	0.142164 (rank : 302)
Query Neighborhood Hits	479	Target Neighborhood Hits	844	Shared Neighborhood Hits	212
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CK5P2_MOUSE
θ value	0.47712 (rank : 263)	NC score	0.146915 (rank : 280)
Query Neighborhood Hits	479	Target Neighborhood Hits	1151	Shared Neighborhood Hits	223
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

DNMBP_MOUSE
θ value	0.47712 (rank : 264)	NC score	0.190456 (rank : 188)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	142
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LTBP2_MOUSE
θ value	0.47712 (rank : 265)	NC score	0.002301 (rank : 1457)
Query Neighborhood Hits	479	Target Neighborhood Hits	617	Shared Neighborhood Hits	7
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MAP9_HUMAN
θ value	0.47712 (rank : 266)	NC score	0.106007 (rank : 564)
Query Neighborhood Hits	479	Target Neighborhood Hits	518	Shared Neighborhood Hits	133
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

RB6I2_MOUSE
θ value	0.47712 (rank : 267)	NC score	0.144540 (rank : 293)
Query Neighborhood Hits	479	Target Neighborhood Hits	1433	Shared Neighborhood Hits	234
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

ROCK2_MOUSE
θ value	0.47712 (rank : 268)	NC score	0.106551 (rank : 558)
Query Neighborhood Hits	479	Target Neighborhood Hits	2072	Shared Neighborhood Hits	279
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SAS6_MOUSE
θ value	0.47712 (rank : 269)	NC score	0.146443 (rank : 284)
Query Neighborhood Hits	479	Target Neighborhood Hits	931	Shared Neighborhood Hits	208
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SSNA1_MOUSE
θ value	0.47712 (rank : 270)	NC score	0.091432 (rank : 772)
Query Neighborhood Hits	479	Target Neighborhood Hits	182	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JJ94	Gene names	Ssna1
Domain Architecture	No domain graphic available
Description	Sjoegren syndrome nuclear autoantigen 1 homolog.

STAT1_HUMAN
θ value	0.47712 (rank : 271)	NC score	0.058916 (rank : 1171)
Query Neighborhood Hits	479	Target Neighborhood Hits	128	Shared Neighborhood Hits	59
SwissProt Accessions	P42224	Gene names	STAT1
Domain Architecture
Description	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84).

TPR_HUMAN
θ value	0.47712 (rank : 272)	NC score	0.134856 (rank : 322)
Query Neighborhood Hits	479	Target Neighborhood Hits	1921	Shared Neighborhood Hits	254
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TRHY_HUMAN
θ value	0.47712 (rank : 273)	NC score	0.150545 (rank : 270)
Query Neighborhood Hits	479	Target Neighborhood Hits	1385	Shared Neighborhood Hits	239
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

BPAEA_MOUSE
θ value	0.62314 (rank : 274)	NC score	0.133541 (rank : 333)
Query Neighborhood Hits	479	Target Neighborhood Hits	1480	Shared Neighborhood Hits	243
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CCD45_HUMAN
θ value	0.62314 (rank : 275)	NC score	0.104377 (rank : 585)
Query Neighborhood Hits	479	Target Neighborhood Hits	525	Shared Neighborhood Hits	141
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CD2AP_HUMAN
θ value	0.62314 (rank : 276)	NC score	0.206535 (rank : 154)
Query Neighborhood Hits	479	Target Neighborhood Hits	315	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	0.62314 (rank : 277)	NC score	0.199582 (rank : 172)
Query Neighborhood Hits	479	Target Neighborhood Hits	336	Shared Neighborhood Hits	123
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CIP4_HUMAN
θ value	0.62314 (rank : 278)	NC score	0.184332 (rank : 203)
Query Neighborhood Hits	479	Target Neighborhood Hits	374	Shared Neighborhood Hits	145
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CT2NL_HUMAN
θ value	0.62314 (rank : 279)	NC score	0.116889 (rank : 462)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	204
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

EVPL_HUMAN
θ value	0.62314 (rank : 280)	NC score	0.126496 (rank : 391)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	209
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

K0555_HUMAN
θ value	0.62314 (rank : 281)	NC score	0.138515 (rank : 308)
Query Neighborhood Hits	479	Target Neighborhood Hits	880	Shared Neighborhood Hits	198
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

REST_HUMAN
θ value	0.62314 (rank : 282)	NC score	0.129199 (rank : 373)
Query Neighborhood Hits	479	Target Neighborhood Hits	1605	Shared Neighborhood Hits	236
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SH22A_HUMAN
θ value	0.62314 (rank : 283)	NC score	0.246124 (rank : 123)
Query Neighborhood Hits	479	Target Neighborhood Hits	144	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SPG3A_MOUSE
θ value	0.62314 (rank : 284)	NC score	0.030175 (rank : 1441)
Query Neighborhood Hits	479	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BH66, Q8BJH5	Gene names	Spg3a, Gbp3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3).

SSNA1_HUMAN
θ value	0.62314 (rank : 285)	NC score	0.086445 (rank : 838)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	62
SwissProt Accessions	O43805, Q6FG70, Q9BVW8	Gene names	SSNA1, NA14
Domain Architecture
Description	Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa).

STS2_HUMAN
θ value	0.62314 (rank : 286)	NC score	0.098111 (rank : 677)
Query Neighborhood Hits	479	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ZN291_HUMAN
θ value	0.62314 (rank : 287)	NC score	0.136647 (rank : 314)
Query Neighborhood Hits	479	Target Neighborhood Hits	647	Shared Neighborhood Hits	174
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

BCAR3_HUMAN
θ value	0.813845 (rank : 288)	NC score	0.180662 (rank : 209)
Query Neighborhood Hits	479	Target Neighborhood Hits	129	Shared Neighborhood Hits	81
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

CASP_MOUSE
θ value	0.813845 (rank : 289)	NC score	0.125469 (rank : 397)
Query Neighborhood Hits	479	Target Neighborhood Hits	1152	Shared Neighborhood Hits	224
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_MOUSE
θ value	0.813845 (rank : 290)	NC score	0.123474 (rank : 414)
Query Neighborhood Hits	479	Target Neighborhood Hits	1620	Shared Neighborhood Hits	226
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

GCF_HUMAN
θ value	0.813845 (rank : 291)	NC score	0.043805 (rank : 1432)
Query Neighborhood Hits	479	Target Neighborhood Hits	107	Shared Neighborhood Hits	42
SwissProt Accessions	P16383, O95032	Gene names	TCF9, C2orf3
Domain Architecture	No domain graphic available
Description	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9).

GOGA4_HUMAN
θ value	0.813845 (rank : 292)	NC score	0.153778 (rank : 256)
Query Neighborhood Hits	479	Target Neighborhood Hits	2034	Shared Neighborhood Hits	268
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GP73_HUMAN
θ value	0.813845 (rank : 293)	NC score	0.089220 (rank : 803)
Query Neighborhood Hits	479	Target Neighborhood Hits	309	Shared Neighborhood Hits	108
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

IF3A_MOUSE
θ value	0.813845 (rank : 294)	NC score	0.160914 (rank : 233)
Query Neighborhood Hits	479	Target Neighborhood Hits	871	Shared Neighborhood Hits	201
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

LAMA4_MOUSE
θ value	0.813845 (rank : 295)	NC score	0.047027 (rank : 1428)
Query Neighborhood Hits	479	Target Neighborhood Hits	584	Shared Neighborhood Hits	117
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

MYH11_MOUSE
θ value	0.813845 (rank : 296)	NC score	0.131975 (rank : 346)
Query Neighborhood Hits	479	Target Neighborhood Hits	1777	Shared Neighborhood Hits	257
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NEBU_HUMAN
θ value	0.813845 (rank : 297)	NC score	0.145255 (rank : 287)
Query Neighborhood Hits	479	Target Neighborhood Hits	420	Shared Neighborhood Hits	148
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

S6OS1_HUMAN
θ value	0.813845 (rank : 298)	NC score	0.099958 (rank : 649)
Query Neighborhood Hits	479	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N1H7	Gene names	SIX6OS1, C14orf39
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

SMC2_HUMAN
θ value	0.813845 (rank : 299)	NC score	0.131212 (rank : 355)
Query Neighborhood Hits	479	Target Neighborhood Hits	1405	Shared Neighborhood Hits	233
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

TACC3_MOUSE
θ value	0.813845 (rank : 300)	NC score	0.109632 (rank : 524)
Query Neighborhood Hits	479	Target Neighborhood Hits	607	Shared Neighborhood Hits	157
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

3BP2_HUMAN
θ value	1.06291 (rank : 301)	NC score	0.098933 (rank : 665)
Query Neighborhood Hits	479	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ADIP_MOUSE
θ value	1.06291 (rank : 302)	NC score	0.111009 (rank : 501)
Query Neighborhood Hits	479	Target Neighborhood Hits	415	Shared Neighborhood Hits	139
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

CE290_HUMAN
θ value	1.06291 (rank : 303)	NC score	0.148946 (rank : 276)
Query Neighborhood Hits	479	Target Neighborhood Hits	1553	Shared Neighborhood Hits	247
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CKAP4_MOUSE
θ value	1.06291 (rank : 304)	NC score	0.124687 (rank : 406)
Query Neighborhood Hits	479	Target Neighborhood Hits	596	Shared Neighborhood Hits	165
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CTGE5_HUMAN
θ value	1.06291 (rank : 305)	NC score	0.117067 (rank : 460)
Query Neighborhood Hits	479	Target Neighborhood Hits	800	Shared Neighborhood Hits	210
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

DBNL_HUMAN
θ value	1.06291 (rank : 306)	NC score	0.150699 (rank : 269)
Query Neighborhood Hits	479	Target Neighborhood Hits	244	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

GOGA5_HUMAN
θ value	1.06291 (rank : 307)	NC score	0.116904 (rank : 461)
Query Neighborhood Hits	479	Target Neighborhood Hits	1168	Shared Neighborhood Hits	212
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

HSH2D_HUMAN
θ value	1.06291 (rank : 308)	NC score	0.299228 (rank : 99)
Query Neighborhood Hits	479	Target Neighborhood Hits	159	Shared Neighborhood Hits	112
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IF3A_HUMAN
θ value	1.06291 (rank : 309)	NC score	0.160768 (rank : 234)
Query Neighborhood Hits	479	Target Neighborhood Hits	875	Shared Neighborhood Hits	200
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

KINH_MOUSE
θ value	1.06291 (rank : 310)	NC score	0.102275 (rank : 610)
Query Neighborhood Hits	479	Target Neighborhood Hits	1082	Shared Neighborhood Hits	226
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

NAF1_HUMAN
θ value	1.06291 (rank : 311)	NC score	0.120472 (rank : 433)
Query Neighborhood Hits	479	Target Neighborhood Hits	937	Shared Neighborhood Hits	192
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

PACN2_HUMAN
θ value	1.06291 (rank : 312)	NC score	0.193249 (rank : 179)
Query Neighborhood Hits	479	Target Neighborhood Hits	339	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	1.06291 (rank : 313)	NC score	0.191370 (rank : 185)
Query Neighborhood Hits	479	Target Neighborhood Hits	382	Shared Neighborhood Hits	164
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PEX13_HUMAN
θ value	1.06291 (rank : 314)	NC score	0.131113 (rank : 358)
Query Neighborhood Hits	479	Target Neighborhood Hits	128	Shared Neighborhood Hits	70
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

POF1B_MOUSE
θ value	1.06291 (rank : 315)	NC score	0.110956 (rank : 503)
Query Neighborhood Hits	479	Target Neighborhood Hits	530	Shared Neighborhood Hits	168
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

RADI_HUMAN
θ value	1.06291 (rank : 316)	NC score	0.109906 (rank : 520)
Query Neighborhood Hits	479	Target Neighborhood Hits	741	Shared Neighborhood Hits	187
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

TENS1_HUMAN
θ value	1.06291 (rank : 317)	NC score	0.105188 (rank : 572)
Query Neighborhood Hits	479	Target Neighborhood Hits	400	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

ANR26_MOUSE
θ value	1.38821 (rank : 318)	NC score	0.107298 (rank : 543)
Query Neighborhood Hits	479	Target Neighborhood Hits	1554	Shared Neighborhood Hits	232
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CCD39_MOUSE
θ value	1.38821 (rank : 319)	NC score	0.132930 (rank : 337)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	219
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CT2NL_MOUSE
θ value	1.38821 (rank : 320)	NC score	0.109767 (rank : 522)
Query Neighborhood Hits	479	Target Neighborhood Hits	902	Shared Neighborhood Hits	183
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GOGA1_HUMAN
θ value	1.38821 (rank : 321)	NC score	0.134487 (rank : 327)
Query Neighborhood Hits	479	Target Neighborhood Hits	1222	Shared Neighborhood Hits	237
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MRCKA_HUMAN
θ value	1.38821 (rank : 322)	NC score	0.113839 (rank : 480)
Query Neighborhood Hits	479	Target Neighborhood Hits	1999	Shared Neighborhood Hits	288
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

POF1B_HUMAN
θ value	1.38821 (rank : 323)	NC score	0.107156 (rank : 546)
Query Neighborhood Hits	479	Target Neighborhood Hits	494	Shared Neighborhood Hits	160
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

SH3K1_MOUSE
θ value	1.38821 (rank : 324)	NC score	0.190612 (rank : 187)
Query Neighborhood Hits	479	Target Neighborhood Hits	332	Shared Neighborhood Hits	128
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SMC3_HUMAN
θ value	1.38821 (rank : 325)	NC score	0.149440 (rank : 275)
Query Neighborhood Hits	479	Target Neighborhood Hits	1186	Shared Neighborhood Hits	224
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	1.38821 (rank : 326)	NC score	0.149736 (rank : 274)
Query Neighborhood Hits	479	Target Neighborhood Hits	1187	Shared Neighborhood Hits	224
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

STA5A_HUMAN
θ value	1.38821 (rank : 327)	NC score	0.060995 (rank : 1137)
Query Neighborhood Hits	479	Target Neighborhood Hits	140	Shared Neighborhood Hits	64
SwissProt Accessions	P42229	Gene names	STAT5A, STAT5
Domain Architecture
Description	Signal transducer and activator of transcription 5A.

STA5A_MOUSE
θ value	1.38821 (rank : 328)	NC score	0.059567 (rank : 1160)
Query Neighborhood Hits	479	Target Neighborhood Hits	128	Shared Neighborhood Hits	60
SwissProt Accessions	P42230	Gene names	Stat5a, Mgf, Mpf
Domain Architecture
Description	Signal transducer and activator of transcription 5A (Mammary gland factor).

SYCP1_HUMAN
θ value	1.38821 (rank : 329)	NC score	0.137612 (rank : 311)
Query Neighborhood Hits	479	Target Neighborhood Hits	1313	Shared Neighborhood Hits	239
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TACC3_HUMAN
θ value	1.38821 (rank : 330)	NC score	0.139575 (rank : 306)
Query Neighborhood Hits	479	Target Neighborhood Hits	779	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ABI1_MOUSE
θ value	1.81305 (rank : 331)	NC score	0.161849 (rank : 232)
Query Neighborhood Hits	479	Target Neighborhood Hits	246	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CASP_HUMAN
θ value	1.81305 (rank : 332)	NC score	0.131912 (rank : 349)
Query Neighborhood Hits	479	Target Neighborhood Hits	1131	Shared Neighborhood Hits	220
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD38_HUMAN
θ value	1.81305 (rank : 333)	NC score	0.075780 (rank : 945)
Query Neighborhood Hits	479	Target Neighborhood Hits	287	Shared Neighborhood Hits	104
SwissProt Accessions	Q502W7, Q8N835	Gene names	CCDC38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

CEP70_MOUSE
θ value	1.81305 (rank : 334)	NC score	0.100669 (rank : 631)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	159
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

CING_MOUSE
θ value	1.81305 (rank : 335)	NC score	0.129112 (rank : 374)
Query Neighborhood Hits	479	Target Neighborhood Hits	1432	Shared Neighborhood Hits	242
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CIP1_HUMAN
θ value	1.81305 (rank : 336)	NC score	0.043687 (rank : 1433)
Query Neighborhood Hits	479	Target Neighborhood Hits	83	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NPC3	Gene names	CCNB1IP1, C14orf18, HEI10
Domain Architecture	No domain graphic available
Description	Cyclin-B1-interacting protein 1 (EC 6.3.2.-) (Human enhancer of invasion 10) (E3 ubiquitin-protein ligase HEI10).

CUTL1_HUMAN
θ value	1.81305 (rank : 337)	NC score	0.117715 (rank : 452)
Query Neighborhood Hits	479	Target Neighborhood Hits	1574	Shared Neighborhood Hits	217
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

DBNL_MOUSE
θ value	1.81305 (rank : 338)	NC score	0.143637 (rank : 297)
Query Neighborhood Hits	479	Target Neighborhood Hits	306	Shared Neighborhood Hits	110
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

IFT74_MOUSE
θ value	1.81305 (rank : 339)	NC score	0.130410 (rank : 360)
Query Neighborhood Hits	479	Target Neighborhood Hits	939	Shared Neighborhood Hits	224
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

K0460_MOUSE
θ value	1.81305 (rank : 340)	NC score	0.032027 (rank : 1439)
Query Neighborhood Hits	479	Target Neighborhood Hits	374	Shared Neighborhood Hits	52
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

LAMA4_HUMAN
θ value	1.81305 (rank : 341)	NC score	0.055500 (rank : 1239)
Query Neighborhood Hits	479	Target Neighborhood Hits	708	Shared Neighborhood Hits	138
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

M3K7_HUMAN
θ value	1.81305 (rank : 342)	NC score	0.082696 (rank : 870)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	80
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	1.81305 (rank : 343)	NC score	0.082751 (rank : 869)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	81
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MYH7_HUMAN
θ value	1.81305 (rank : 344)	NC score	0.120947 (rank : 429)
Query Neighborhood Hits	479	Target Neighborhood Hits	1559	Shared Neighborhood Hits	249
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

PLCB1_HUMAN
θ value	1.81305 (rank : 345)	NC score	0.109704 (rank : 523)
Query Neighborhood Hits	479	Target Neighborhood Hits	614	Shared Neighborhood Hits	170
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

RFIP3_HUMAN
θ value	1.81305 (rank : 346)	NC score	0.124030 (rank : 410)
Query Neighborhood Hits	479	Target Neighborhood Hits	1055	Shared Neighborhood Hits	206
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

SPG3A_HUMAN
θ value	1.81305 (rank : 347)	NC score	0.026684 (rank : 1443)
Query Neighborhood Hits	479	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXF7, O95890, Q96FK0	Gene names	SPG3A, GBP3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3) (Brain-specific GTP-binding protein).

TAXB1_MOUSE
θ value	1.81305 (rank : 348)	NC score	0.120624 (rank : 430)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	205
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

TENS4_MOUSE
θ value	1.81305 (rank : 349)	NC score	0.158956 (rank : 238)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

BRPF3_HUMAN
θ value	2.36792 (rank : 350)	NC score	0.005386 (rank : 1454)
Query Neighborhood Hits	479	Target Neighborhood Hits	217	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

CCD38_MOUSE
θ value	2.36792 (rank : 351)	NC score	0.061849 (rank : 1117)
Query Neighborhood Hits	479	Target Neighborhood Hits	165	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CDN8, Q8CDD6, Q8CDE1	Gene names	Ccdc38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

CCD45_MOUSE
θ value	2.36792 (rank : 352)	NC score	0.097818 (rank : 683)
Query Neighborhood Hits	479	Target Neighborhood Hits	663	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CEP63_HUMAN
θ value	2.36792 (rank : 353)	NC score	0.127057 (rank : 388)
Query Neighborhood Hits	479	Target Neighborhood Hits	1005	Shared Neighborhood Hits	213
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CTGE4_HUMAN
θ value	2.36792 (rank : 354)	NC score	0.081985 (rank : 880)
Query Neighborhood Hits	479	Target Neighborhood Hits	393	Shared Neighborhood Hits	137
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

FES_HUMAN
θ value	2.36792 (rank : 355)	NC score	0.135916 (rank : 317)
Query Neighborhood Hits	479	Target Neighborhood Hits	978	Shared Neighborhood Hits	135
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

HC127_HUMAN
θ value	2.36792 (rank : 356)	NC score	0.093977 (rank : 743)
Query Neighborhood Hits	479	Target Neighborhood Hits	292	Shared Neighborhood Hits	118
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
θ value	2.36792 (rank : 357)	NC score	0.093977 (rank : 744)
Query Neighborhood Hits	479	Target Neighborhood Hits	292	Shared Neighborhood Hits	118
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

HMMR_HUMAN
θ value	2.36792 (rank : 358)	NC score	0.142898 (rank : 300)
Query Neighborhood Hits	479	Target Neighborhood Hits	1082	Shared Neighborhood Hits	220
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

JIP1_HUMAN
θ value	2.36792 (rank : 359)	NC score	0.056036 (rank : 1230)
Query Neighborhood Hits	479	Target Neighborhood Hits	271	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	2.36792 (rank : 360)	NC score	0.056060 (rank : 1229)
Query Neighborhood Hits	479	Target Neighborhood Hits	259	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	2.36792 (rank : 361)	NC score	0.061404 (rank : 1128)
Query Neighborhood Hits	479	Target Neighborhood Hits	288	Shared Neighborhood Hits	43
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	2.36792 (rank : 362)	NC score	0.062437 (rank : 1104)
Query Neighborhood Hits	479	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K1C14_MOUSE
θ value	2.36792 (rank : 363)	NC score	0.049874 (rank : 1424)
Query Neighborhood Hits	479	Target Neighborhood Hits	501	Shared Neighborhood Hits	154
SwissProt Accessions	Q61781, Q91VQ4	Gene names	Krt14, Krt1-14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

K2C5_MOUSE
θ value	2.36792 (rank : 364)	NC score	0.048787 (rank : 1426)
Query Neighborhood Hits	479	Target Neighborhood Hits	505	Shared Neighborhood Hits	154
SwissProt Accessions	Q922U2, Q920F2	Gene names	Krt5, Krt2-5
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5).

K2C6A_HUMAN
θ value	2.36792 (rank : 365)	NC score	0.052877 (rank : 1319)
Query Neighborhood Hits	479	Target Neighborhood Hits	505	Shared Neighborhood Hits	151
SwissProt Accessions	P02538, Q6NT67, Q96CL4	Gene names	KRT6A, K6A
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin).

K2C6B_HUMAN
θ value	2.36792 (rank : 366)	NC score	0.055277 (rank : 1243)
Query Neighborhood Hits	479	Target Neighborhood Hits	526	Shared Neighborhood Hits	157
SwissProt Accessions	P04259, P48669	Gene names	KRT6B, K6B
Domain Architecture
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin).

K2C6C_HUMAN
θ value	2.36792 (rank : 367)	NC score	0.053018 (rank : 1314)
Query Neighborhood Hits	479	Target Neighborhood Hits	503	Shared Neighborhood Hits	151
SwissProt Accessions	P48666	Gene names	KRT6C
Domain Architecture
Description	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK 6C) (K6c keratin).

K2C6E_HUMAN
θ value	2.36792 (rank : 368)	NC score	0.055174 (rank : 1248)
Query Neighborhood Hits	479	Target Neighborhood Hits	516	Shared Neighborhood Hits	153
SwissProt Accessions	P48668, Q7RTN9	Gene names	KRT6E
Domain Architecture
Description	Keratin, type II cytoskeletal 6E (Cytokeratin-6E) (CK 6E) (K6e keratin) (Keratin K6h).

KI21A_MOUSE
θ value	2.36792 (rank : 369)	NC score	0.073093 (rank : 976)
Query Neighborhood Hits	479	Target Neighborhood Hits	1317	Shared Neighborhood Hits	204
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

NUF2_HUMAN
θ value	2.36792 (rank : 370)	NC score	0.106247 (rank : 562)
Query Neighborhood Hits	479	Target Neighborhood Hits	661	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

ROCK1_MOUSE
θ value	2.36792 (rank : 371)	NC score	0.109065 (rank : 529)
Query Neighborhood Hits	479	Target Neighborhood Hits	2126	Shared Neighborhood Hits	288
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

U2AFL_HUMAN
θ value	2.36792 (rank : 372)	NC score	0.064417 (rank : 1079)
Query Neighborhood Hits	479	Target Neighborhood Hits	503	Shared Neighborhood Hits	138
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

ABI1_HUMAN
θ value	3.0926 (rank : 373)	NC score	0.152844 (rank : 262)
Query Neighborhood Hits	479	Target Neighborhood Hits	257	Shared Neighborhood Hits	99
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

AZI1_HUMAN
θ value	3.0926 (rank : 374)	NC score	0.129340 (rank : 371)
Query Neighborhood Hits	479	Target Neighborhood Hits	1000	Shared Neighborhood Hits	209
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CARD9_HUMAN
θ value	3.0926 (rank : 375)	NC score	0.111063 (rank : 500)
Query Neighborhood Hits	479	Target Neighborhood Hits	602	Shared Neighborhood Hits	172
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CCD46_HUMAN
θ value	3.0926 (rank : 376)	NC score	0.132321 (rank : 341)
Query Neighborhood Hits	479	Target Neighborhood Hits	1430	Shared Neighborhood Hits	249
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CTGE6_HUMAN
θ value	3.0926 (rank : 377)	NC score	0.110379 (rank : 512)
Query Neighborhood Hits	479	Target Neighborhood Hits	650	Shared Neighborhood Hits	183
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

FCER2_MOUSE
θ value	3.0926 (rank : 378)	NC score	0.033682 (rank : 1438)
Query Neighborhood Hits	479	Target Neighborhood Hits	392	Shared Neighborhood Hits	97
SwissProt Accessions	P20693, Q61556, Q61557	Gene names	Fcer2, Fcer2a
Domain Architecture
Description	Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IGE receptor) (Fc-epsilon-RII) (CD23 antigen).

FES_MOUSE
θ value	3.0926 (rank : 379)	NC score	0.129525 (rank : 369)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	138
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FYCO1_MOUSE
θ value	3.0926 (rank : 380)	NC score	0.121512 (rank : 426)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	210
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GAS8_MOUSE
θ value	3.0926 (rank : 381)	NC score	0.119543 (rank : 437)
Query Neighborhood Hits	479	Target Neighborhood Hits	622	Shared Neighborhood Hits	182
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

MAP1A_HUMAN
θ value	3.0926 (rank : 382)	NC score	0.089163 (rank : 805)
Query Neighborhood Hits	479	Target Neighborhood Hits	1626	Shared Neighborhood Hits	204
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MOES_MOUSE
θ value	3.0926 (rank : 383)	NC score	0.103839 (rank : 593)
Query Neighborhood Hits	479	Target Neighborhood Hits	923	Shared Neighborhood Hits	208
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MRCKB_HUMAN
θ value	3.0926 (rank : 384)	NC score	0.108533 (rank : 531)
Query Neighborhood Hits	479	Target Neighborhood Hits	2239	Shared Neighborhood Hits	290
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MY18A_HUMAN
θ value	3.0926 (rank : 385)	NC score	0.133576 (rank : 332)
Query Neighborhood Hits	479	Target Neighborhood Hits	1929	Shared Neighborhood Hits	270
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NFM_MOUSE
θ value	3.0926 (rank : 386)	NC score	0.072838 (rank : 981)
Query Neighborhood Hits	479	Target Neighborhood Hits	1159	Shared Neighborhood Hits	212
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

ROCK2_HUMAN
θ value	3.0926 (rank : 387)	NC score	0.102804 (rank : 601)
Query Neighborhood Hits	479	Target Neighborhood Hits	2073	Shared Neighborhood Hits	278
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SH3G1_HUMAN
θ value	3.0926 (rank : 388)	NC score	0.143926 (rank : 295)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	140
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STA5B_HUMAN
θ value	3.0926 (rank : 389)	NC score	0.056807 (rank : 1208)
Query Neighborhood Hits	479	Target Neighborhood Hits	103	Shared Neighborhood Hits	57
SwissProt Accessions	P51692, Q8WWS8	Gene names	STAT5B
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

STA5B_MOUSE
θ value	3.0926 (rank : 390)	NC score	0.057320 (rank : 1200)
Query Neighborhood Hits	479	Target Neighborhood Hits	124	Shared Neighborhood Hits	62
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

TBC14_MOUSE
θ value	3.0926 (rank : 391)	NC score	0.011215 (rank : 1453)
Query Neighborhood Hits	479	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CGA2, Q8CHA5	Gene names	Tbc1d14, D5Ertd110e, Kiaa1322
Domain Architecture
Description	TBC1 domain family member 14.

TENS4_HUMAN
θ value	3.0926 (rank : 392)	NC score	0.146660 (rank : 282)
Query Neighborhood Hits	479	Target Neighborhood Hits	214	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TTC19_HUMAN
θ value	3.0926 (rank : 393)	NC score	0.022314 (rank : 1445)
Query Neighborhood Hits	479	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q6DKK2, Q7L3U8, Q9NXB2	Gene names	TTC19
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 19 (TPR repeat protein 19).

CAR14_HUMAN
θ value	4.03905 (rank : 394)	NC score	0.110867 (rank : 506)
Query Neighborhood Hits	479	Target Neighborhood Hits	449	Shared Neighborhood Hits	147
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CCD42_HUMAN
θ value	4.03905 (rank : 395)	NC score	0.081735 (rank : 881)
Query Neighborhood Hits	479	Target Neighborhood Hits	406	Shared Neighborhood Hits	137
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CP250_MOUSE
θ value	4.03905 (rank : 396)	NC score	0.133459 (rank : 335)
Query Neighborhood Hits	479	Target Neighborhood Hits	1583	Shared Neighborhood Hits	241
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CTGE5_MOUSE
θ value	4.03905 (rank : 397)	NC score	0.124776 (rank : 403)
Query Neighborhood Hits	479	Target Neighborhood Hits	928	Shared Neighborhood Hits	213
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

EEA1_HUMAN
θ value	4.03905 (rank : 398)	NC score	0.136975 (rank : 313)
Query Neighborhood Hits	479	Target Neighborhood Hits	1796	Shared Neighborhood Hits	260
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EFS_MOUSE
θ value	4.03905 (rank : 399)	NC score	0.112824 (rank : 488)
Query Neighborhood Hits	479	Target Neighborhood Hits	389	Shared Neighborhood Hits	95
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

HOOK1_MOUSE
θ value	4.03905 (rank : 400)	NC score	0.131991 (rank : 345)
Query Neighborhood Hits	479	Target Neighborhood Hits	910	Shared Neighborhood Hits	217
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

K1C14_HUMAN
θ value	4.03905 (rank : 401)	NC score	0.045629 (rank : 1430)
Query Neighborhood Hits	479	Target Neighborhood Hits	491	Shared Neighborhood Hits	148
SwissProt Accessions	P02533, Q14715, Q53XY3, Q9BUE3, Q9UBN2, Q9UBN3, Q9UCY4	Gene names	KRT14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

K2C5_HUMAN
θ value	4.03905 (rank : 402)	NC score	0.050395 (rank : 1408)
Query Neighborhood Hits	479	Target Neighborhood Hits	506	Shared Neighborhood Hits	153
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

LRRF2_HUMAN
θ value	4.03905 (rank : 403)	NC score	0.115882 (rank : 465)
Query Neighborhood Hits	479	Target Neighborhood Hits	791	Shared Neighborhood Hits	192
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

MACF1_HUMAN
θ value	4.03905 (rank : 404)	NC score	0.100965 (rank : 626)
Query Neighborhood Hits	479	Target Neighborhood Hits	1341	Shared Neighborhood Hits	227
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	4.03905 (rank : 405)	NC score	0.096609 (rank : 706)
Query Neighborhood Hits	479	Target Neighborhood Hits	1321	Shared Neighborhood Hits	216
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

RADI_MOUSE
θ value	4.03905 (rank : 406)	NC score	0.102270 (rank : 611)
Query Neighborhood Hits	479	Target Neighborhood Hits	773	Shared Neighborhood Hits	194
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

REN3B_HUMAN
θ value	4.03905 (rank : 407)	NC score	0.100198 (rank : 642)
Query Neighborhood Hits	479	Target Neighborhood Hits	412	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

STK10_HUMAN
θ value	4.03905 (rank : 408)	NC score	0.092881 (rank : 756)
Query Neighborhood Hits	479	Target Neighborhood Hits	1921	Shared Neighborhood Hits	237
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TEKT1_HUMAN
θ value	4.03905 (rank : 409)	NC score	0.072991 (rank : 978)
Query Neighborhood Hits	479	Target Neighborhood Hits	289	Shared Neighborhood Hits	111
SwissProt Accessions	Q969V4	Gene names	TEKT1
Domain Architecture
Description	Tektin-1.

TRIPB_HUMAN
θ value	4.03905 (rank : 410)	NC score	0.134517 (rank : 326)
Query Neighborhood Hits	479	Target Neighborhood Hits	1587	Shared Neighborhood Hits	258
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

U2AFM_HUMAN
θ value	4.03905 (rank : 411)	NC score	0.071183 (rank : 999)
Query Neighborhood Hits	479	Target Neighborhood Hits	577	Shared Neighborhood Hits	143
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

XE7_HUMAN
θ value	4.03905 (rank : 412)	NC score	0.134380 (rank : 328)
Query Neighborhood Hits	479	Target Neighborhood Hits	738	Shared Neighborhood Hits	178
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

AMRP_MOUSE
θ value	5.27518 (rank : 413)	NC score	0.066028 (rank : 1061)
Query Neighborhood Hits	479	Target Neighborhood Hits	173	Shared Neighborhood Hits	79
SwissProt Accessions	P55302	Gene names	Lrpap1
Domain Architecture
Description	Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2- MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin-binding protein 44) (HBP-44).

ANR12_HUMAN
θ value	5.27518 (rank : 414)	NC score	0.069131 (rank : 1028)
Query Neighborhood Hits	479	Target Neighborhood Hits	1081	Shared Neighborhood Hits	172
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

BRE1A_MOUSE
θ value	5.27518 (rank : 415)	NC score	0.115805 (rank : 466)
Query Neighborhood Hits	479	Target Neighborhood Hits	1025	Shared Neighborhood Hits	212
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CCD91_MOUSE
θ value	5.27518 (rank : 416)	NC score	0.106780 (rank : 551)
Query Neighborhood Hits	479	Target Neighborhood Hits	699	Shared Neighborhood Hits	171
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CEP55_MOUSE
θ value	5.27518 (rank : 417)	NC score	0.126029 (rank : 393)
Query Neighborhood Hits	479	Target Neighborhood Hits	693	Shared Neighborhood Hits	193
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CTGE2_HUMAN
θ value	5.27518 (rank : 418)	NC score	0.104618 (rank : 582)
Query Neighborhood Hits	479	Target Neighborhood Hits	594	Shared Neighborhood Hits	173
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

EP15R_MOUSE
θ value	5.27518 (rank : 419)	NC score	0.115221 (rank : 468)
Query Neighborhood Hits	479	Target Neighborhood Hits	1135	Shared Neighborhood Hits	206
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

KCY_MOUSE
θ value	5.27518 (rank : 420)	NC score	0.030073 (rank : 1442)
Query Neighborhood Hits	479	Target Neighborhood Hits	25	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DBP5	Gene names	Cmpk, Cmk, Uck, Umk, Umpk
Domain Architecture
Description	UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase).

MOES_HUMAN
θ value	5.27518 (rank : 421)	NC score	0.107761 (rank : 538)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	211
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYH11_HUMAN
θ value	5.27518 (rank : 422)	NC score	0.128203 (rank : 378)
Query Neighborhood Hits	479	Target Neighborhood Hits	1806	Shared Neighborhood Hits	257
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NCF2_HUMAN
θ value	5.27518 (rank : 423)	NC score	0.181895 (rank : 204)
Query Neighborhood Hits	479	Target Neighborhood Hits	229	Shared Neighborhood Hits	102
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NIN_HUMAN
θ value	5.27518 (rank : 424)	NC score	0.121091 (rank : 428)
Query Neighborhood Hits	479	Target Neighborhood Hits	1416	Shared Neighborhood Hits	232
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

RBCC1_MOUSE
θ value	5.27518 (rank : 425)	NC score	0.133336 (rank : 336)
Query Neighborhood Hits	479	Target Neighborhood Hits	1048	Shared Neighborhood Hits	221
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

STAT2_MOUSE
θ value	5.27518 (rank : 426)	NC score	0.041951 (rank : 1435)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

SYNE1_HUMAN
θ value	5.27518 (rank : 427)	NC score	0.101942 (rank : 614)
Query Neighborhood Hits	479	Target Neighborhood Hits	1484	Shared Neighborhood Hits	226
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TAOK1_HUMAN
θ value	5.27518 (rank : 428)	NC score	0.088510 (rank : 812)
Query Neighborhood Hits	479	Target Neighborhood Hits	1734	Shared Neighborhood Hits	234
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	5.27518 (rank : 429)	NC score	0.088015 (rank : 821)
Query Neighborhood Hits	479	Target Neighborhood Hits	1720	Shared Neighborhood Hits	231
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TEKT1_MOUSE
θ value	5.27518 (rank : 430)	NC score	0.080940 (rank : 887)
Query Neighborhood Hits	479	Target Neighborhood Hits	399	Shared Neighborhood Hits	133
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

ARHG2_MOUSE
θ value	6.88961 (rank : 431)	NC score	0.044483 (rank : 1431)
Query Neighborhood Hits	479	Target Neighborhood Hits	120	Shared Neighborhood Hits	23
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

DMD_MOUSE
θ value	6.88961 (rank : 432)	NC score	0.095091 (rank : 732)
Query Neighborhood Hits	479	Target Neighborhood Hits	1111	Shared Neighborhood Hits	215
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

ENAH_MOUSE
θ value	6.88961 (rank : 433)	NC score	0.064900 (rank : 1074)
Query Neighborhood Hits	479	Target Neighborhood Hits	919	Shared Neighborhood Hits	137
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

K1C16_HUMAN
θ value	6.88961 (rank : 434)	NC score	0.040786 (rank : 1436)
Query Neighborhood Hits	479	Target Neighborhood Hits	440	Shared Neighborhood Hits	134
SwissProt Accessions	P08779, P30654, Q16402, Q9UBG8	Gene names	KRT16, KRT16A
Domain Architecture
Description	Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16).

K1C16_MOUSE
θ value	6.88961 (rank : 435)	NC score	0.042487 (rank : 1434)
Query Neighborhood Hits	479	Target Neighborhood Hits	444	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z2K1	Gene names	Krt16, Krt1-16
Domain Architecture
Description	Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16).

KMHN1_MOUSE
θ value	6.88961 (rank : 436)	NC score	0.122483 (rank : 419)
Query Neighborhood Hits	479	Target Neighborhood Hits	949	Shared Neighborhood Hits	206
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

LIPA2_MOUSE
θ value	6.88961 (rank : 437)	NC score	0.105056 (rank : 576)
Query Neighborhood Hits	479	Target Neighborhood Hits	1282	Shared Neighborhood Hits	232
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

MYH1_HUMAN
θ value	6.88961 (rank : 438)	NC score	0.125339 (rank : 398)
Query Neighborhood Hits	479	Target Neighborhood Hits	1478	Shared Neighborhood Hits	251
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH4_MOUSE
θ value	6.88961 (rank : 439)	NC score	0.129071 (rank : 376)
Query Neighborhood Hits	479	Target Neighborhood Hits	1476	Shared Neighborhood Hits	248
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH9_MOUSE
θ value	6.88961 (rank : 440)	NC score	0.128216 (rank : 377)
Query Neighborhood Hits	479	Target Neighborhood Hits	1829	Shared Neighborhood Hits	256
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NCOR1_HUMAN
θ value	6.88961 (rank : 441)	NC score	0.031218 (rank : 1440)
Query Neighborhood Hits	479	Target Neighborhood Hits	577	Shared Neighborhood Hits	72
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

NCOR1_MOUSE
θ value	6.88961 (rank : 442)	NC score	0.026171 (rank : 1444)
Query Neighborhood Hits	479	Target Neighborhood Hits	521	Shared Neighborhood Hits	61
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

PEX13_MOUSE
θ value	6.88961 (rank : 443)	NC score	0.120606 (rank : 431)
Query Neighborhood Hits	479	Target Neighborhood Hits	126	Shared Neighborhood Hits	75
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

REST_MOUSE
θ value	6.88961 (rank : 444)	NC score	0.128141 (rank : 379)
Query Neighborhood Hits	479	Target Neighborhood Hits	1506	Shared Neighborhood Hits	242
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SH3G3_MOUSE
θ value	6.88961 (rank : 445)	NC score	0.141799 (rank : 303)
Query Neighborhood Hits	479	Target Neighborhood Hits	236	Shared Neighborhood Hits	112
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STA13_HUMAN
θ value	6.88961 (rank : 446)	NC score	0.229887 (rank : 132)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

TPM1_HUMAN
θ value	6.88961 (rank : 447)	NC score	0.104341 (rank : 586)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	193
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TTC19_MOUSE
θ value	6.88961 (rank : 448)	NC score	0.014090 (rank : 1450)
Query Neighborhood Hits	479	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CC21	Gene names	Ttc19
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 19 (TPR repeat protein 19).

TUFT1_HUMAN
θ value	6.88961 (rank : 449)	NC score	0.104716 (rank : 580)
Query Neighborhood Hits	479	Target Neighborhood Hits	686	Shared Neighborhood Hits	173
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

ACTN3_HUMAN
θ value	8.99809 (rank : 450)	NC score	0.017082 (rank : 1448)
Query Neighborhood Hits	479	Target Neighborhood Hits	272	Shared Neighborhood Hits	60
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

AR13B_HUMAN
θ value	8.99809 (rank : 451)	NC score	0.014841 (rank : 1449)
Query Neighborhood Hits	479	Target Neighborhood Hits	528	Shared Neighborhood Hits	82
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

CASL_MOUSE
θ value	8.99809 (rank : 452)	NC score	0.076692 (rank : 938)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	84
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CCD41_MOUSE
θ value	8.99809 (rank : 453)	NC score	0.124720 (rank : 404)
Query Neighborhood Hits	479	Target Neighborhood Hits	1399	Shared Neighborhood Hits	232
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CCNL2_MOUSE
θ value	8.99809 (rank : 454)	NC score	0.005326 (rank : 1455)
Query Neighborhood Hits	479	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJA7, Q5XK66, Q60995, Q8C136, Q8CIJ8, Q99L73, Q9QXH5	Gene names	Ccnl2, Ania6b
Domain Architecture	No domain graphic available
Description	Cyclin-L2 (Cyclin Ania-6b) (Paneth cell-enhanced expression protein) (PCEE).

CN094_HUMAN
θ value	8.99809 (rank : 455)	NC score	0.049265 (rank : 1425)
Query Neighborhood Hits	479	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H6D7, Q86T15, Q86T16, Q86U43, Q9NX59	Gene names	C14orf94
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf94.

CTTB2_HUMAN
θ value	8.99809 (rank : 456)	NC score	0.053315 (rank : 1303)
Query Neighborhood Hits	479	Target Neighborhood Hits	1061	Shared Neighborhood Hits	183
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

GOGA3_MOUSE
θ value	8.99809 (rank : 457)	NC score	0.132262 (rank : 342)
Query Neighborhood Hits	479	Target Neighborhood Hits	1437	Shared Neighborhood Hits	235
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GRB7_MOUSE
θ value	8.99809 (rank : 458)	NC score	0.189760 (rank : 190)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

IFT74_HUMAN
θ value	8.99809 (rank : 459)	NC score	0.126394 (rank : 392)
Query Neighborhood Hits	479	Target Neighborhood Hits	949	Shared Neighborhood Hits	209
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

K2C1_HUMAN
θ value	8.99809 (rank : 460)	NC score	0.057779 (rank : 1193)
Query Neighborhood Hits	479	Target Neighborhood Hits	624	Shared Neighborhood Hits	165
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

K2C6A_MOUSE
θ value	8.99809 (rank : 461)	NC score	0.046602 (rank : 1429)
Query Neighborhood Hits	479	Target Neighborhood Hits	481	Shared Neighborhood Hits	147
SwissProt Accessions	P50446, Q9Z332	Gene names	Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin) (Keratin-6 alpha) (mK6-alpha).

KIF3A_HUMAN
θ value	8.99809 (rank : 462)	NC score	0.061075 (rank : 1133)
Query Neighborhood Hits	479	Target Neighborhood Hits	704	Shared Neighborhood Hits	173
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3B_MOUSE
θ value	8.99809 (rank : 463)	NC score	0.062447 (rank : 1103)
Query Neighborhood Hits	479	Target Neighborhood Hits	533	Shared Neighborhood Hits	164
SwissProt Accessions	Q61771	Gene names	Kif3b
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B).

MCM3A_HUMAN
θ value	8.99809 (rank : 464)	NC score	0.013199 (rank : 1451)
Query Neighborhood Hits	479	Target Neighborhood Hits	86	Shared Neighborhood Hits	13
SwissProt Accessions	O60318, Q9UMT4	Gene names	MCM3AP, GANP, KIAA0572, MAP80
Domain Architecture
Description	80 kDa MCM3-associated protein (GANP protein).

MCM3A_MOUSE
θ value	8.99809 (rank : 465)	NC score	0.011677 (rank : 1452)
Query Neighborhood Hits	479	Target Neighborhood Hits	79	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WUU9	Gene names	Mcm3ap, Ganp, Map80
Domain Architecture
Description	80 kDa MCM3-associated protein (GANP protein).

MY18A_MOUSE
θ value	8.99809 (rank : 466)	NC score	0.130337 (rank : 363)
Query Neighborhood Hits	479	Target Neighborhood Hits	1989	Shared Neighborhood Hits	266
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH2_HUMAN
θ value	8.99809 (rank : 467)	NC score	0.122877 (rank : 417)
Query Neighborhood Hits	479	Target Neighborhood Hits	1491	Shared Neighborhood Hits	247
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH9_HUMAN
θ value	8.99809 (rank : 468)	NC score	0.129563 (rank : 368)
Query Neighborhood Hits	479	Target Neighborhood Hits	1762	Shared Neighborhood Hits	260
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

OCLN_HUMAN
θ value	8.99809 (rank : 469)	NC score	0.019764 (rank : 1446)
Query Neighborhood Hits	479	Target Neighborhood Hits	131	Shared Neighborhood Hits	46
SwissProt Accessions	Q16625, Q8N6K1	Gene names	OCLN
Domain Architecture
Description	Occludin.

OPTN_MOUSE
θ value	8.99809 (rank : 470)	NC score	0.111941 (rank : 496)
Query Neighborhood Hits	479	Target Neighborhood Hits	1120	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

RUFY3_HUMAN
θ value	8.99809 (rank : 471)	NC score	0.094211 (rank : 740)
Query Neighborhood Hits	479	Target Neighborhood Hits	594	Shared Neighborhood Hits	174
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SMC4_HUMAN
θ value	8.99809 (rank : 472)	NC score	0.119811 (rank : 436)
Query Neighborhood Hits	479	Target Neighborhood Hits	937	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

STAT2_HUMAN
θ value	8.99809 (rank : 473)	NC score	0.037279 (rank : 1437)
Query Neighborhood Hits	479	Target Neighborhood Hits	99	Shared Neighborhood Hits	35
SwissProt Accessions	P52630, Q16430, Q16431	Gene names	STAT2
Domain Architecture
Description	Signal transducer and activator of transcription 2 (p113).

STS1_MOUSE
θ value	8.99809 (rank : 474)	NC score	0.072706 (rank : 984)
Query Neighborhood Hits	479	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SYP2L_HUMAN
θ value	8.99809 (rank : 475)	NC score	0.002396 (rank : 1456)
Query Neighborhood Hits	479	Target Neighborhood Hits	400	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TEX9_MOUSE
θ value	8.99809 (rank : 476)	NC score	0.130393 (rank : 361)
Query Neighborhood Hits	479	Target Neighborhood Hits	581	Shared Neighborhood Hits	173
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TMCO3_MOUSE
θ value	8.99809 (rank : 477)	NC score	0.048632 (rank : 1427)
Query Neighborhood Hits	479	Target Neighborhood Hits	241	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BH01, Q3UFX1, Q7TMT5, Q8BGL4, Q8R303	Gene names	Tmco3
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor.

TS101_HUMAN
θ value	8.99809 (rank : 478)	NC score	0.064087 (rank : 1084)
Query Neighborhood Hits	479	Target Neighborhood Hits	359	Shared Neighborhood Hits	122
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

TS101_MOUSE
θ value	8.99809 (rank : 479)	NC score	0.054048 (rank : 1288)
Query Neighborhood Hits	479	Target Neighborhood Hits	312	Shared Neighborhood Hits	103
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

3BP5_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.068844 (rank : 1032)
Query Neighborhood Hits	479	Target Neighborhood Hits	375	Shared Neighborhood Hits	120
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

3BP5_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.066594 (rank : 1052)
Query Neighborhood Hits	479	Target Neighborhood Hits	346	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

A20A1_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.053276 (rank : 1308)
Query Neighborhood Hits	479	Target Neighborhood Hits	698	Shared Neighborhood Hits	145
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A2_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.051384 (rank : 1366)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	146
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A3_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.052948 (rank : 1316)
Query Neighborhood Hits	479	Target Neighborhood Hits	692	Shared Neighborhood Hits	149
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.056442 (rank : 1219)
Query Neighborhood Hits	479	Target Neighborhood Hits	710	Shared Neighborhood Hits	152
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

AAPK1_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.051081 (rank : 1384)
Query Neighborhood Hits	479	Target Neighborhood Hits	842	Shared Neighborhood Hits	59
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.050938 (rank : 1391)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	59
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.050583 (rank : 1401)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	58
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.101205 (rank : 620)
Query Neighborhood Hits	479	Target Neighborhood Hits	1243	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.104133 (rank : 589)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI3_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.136382 (rank : 315)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.135130 (rank : 320)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ACINU_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.051360 (rank : 1369)
Query Neighborhood Hits	479	Target Neighborhood Hits	712	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ACK1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.110109 (rank : 514)
Query Neighborhood Hits	479	Target Neighborhood Hits	1140	Shared Neighborhood Hits	88
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.110881 (rank : 505)
Query Neighborhood Hits	479	Target Neighborhood Hits	1080	Shared Neighborhood Hits	87
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.069735 (rank : 1020)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	58
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.069766 (rank : 1018)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	58
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.069800 (rank : 1017)
Query Neighborhood Hits	479	Target Neighborhood Hits	709	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.069520 (rank : 1025)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.070392 (rank : 1008)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	58
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.070830 (rank : 1004)
Query Neighborhood Hits	479	Target Neighborhood Hits	739	Shared Neighborhood Hits	58
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.066730 (rank : 1046)
Query Neighborhood Hits	479	Target Neighborhood Hits	760	Shared Neighborhood Hits	58
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.067075 (rank : 1044)
Query Neighborhood Hits	479	Target Neighborhood Hits	768	Shared Neighborhood Hits	58
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AL2S2_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.050988 (rank : 1387)
Query Neighborhood Hits	479	Target Neighborhood Hits	727	Shared Neighborhood Hits	56
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.053284 (rank : 1307)
Query Neighborhood Hits	479	Target Neighborhood Hits	709	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.052609 (rank : 1326)
Query Neighborhood Hits	479	Target Neighborhood Hits	831	Shared Neighborhood Hits	58
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

AL2SB_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.097832 (rank : 682)
Query Neighborhood Hits	479	Target Neighborhood Hits	294	Shared Neighborhood Hits	127
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

ALK_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.107226 (rank : 544)
Query Neighborhood Hits	479	Target Neighborhood Hits	795	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.107935 (rank : 537)
Query Neighborhood Hits	479	Target Neighborhood Hits	811	Shared Neighborhood Hits	60
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.062980 (rank : 1100)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	58
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMOL1_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.066721 (rank : 1047)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	131
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

AMOL1_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.059620 (rank : 1156)
Query Neighborhood Hits	479	Target Neighborhood Hits	445	Shared Neighborhood Hits	118
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

AMOL2_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.084347 (rank : 862)
Query Neighborhood Hits	479	Target Neighborhood Hits	603	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

AMOL2_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.085384 (rank : 848)
Query Neighborhood Hits	479	Target Neighborhood Hits	591	Shared Neighborhood Hits	162
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

AMOT_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.074932 (rank : 954)
Query Neighborhood Hits	479	Target Neighborhood Hits	712	Shared Neighborhood Hits	155
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

AN30A_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.076964 (rank : 935)
Query Neighborhood Hits	479	Target Neighborhood Hits	1119	Shared Neighborhood Hits	177
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANKK1_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.064190 (rank : 1083)
Query Neighborhood Hits	479	Target Neighborhood Hits	1075	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.065099 (rank : 1073)
Query Neighborhood Hits	479	Target Neighborhood Hits	1072	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANM2_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.105801 (rank : 566)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	85
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.101148 (rank : 624)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRA_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.086733 (rank : 834)
Query Neighborhood Hits	479	Target Neighborhood Hits	612	Shared Neighborhood Hits	56
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.086832 (rank : 833)
Query Neighborhood Hits	479	Target Neighborhood Hits	600	Shared Neighborhood Hits	57
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.087834 (rank : 823)
Query Neighborhood Hits	479	Target Neighborhood Hits	646	Shared Neighborhood Hits	62
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.088275 (rank : 817)
Query Neighborhood Hits	479	Target Neighborhood Hits	607	Shared Neighborhood Hits	62
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANR18_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.079348 (rank : 908)
Query Neighborhood Hits	479	Target Neighborhood Hits	1106	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR26_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.104937 (rank : 577)
Query Neighborhood Hits	479	Target Neighborhood Hits	1614	Shared Neighborhood Hits	235
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APOA4_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.062365 (rank : 1107)
Query Neighborhood Hits	479	Target Neighborhood Hits	399	Shared Neighborhood Hits	112
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APOA4_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.072787 (rank : 983)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	125
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APOE_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.054922 (rank : 1260)
Query Neighborhood Hits	479	Target Neighborhood Hits	319	Shared Neighborhood Hits	104
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

APS_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.211752 (rank : 145)
Query Neighborhood Hits	479	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.168739 (rank : 219)
Query Neighborhood Hits	479	Target Neighborhood Hits	134	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARAF_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.088445 (rank : 813)
Query Neighborhood Hits	479	Target Neighborhood Hits	924	Shared Neighborhood Hits	69
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.088927 (rank : 808)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	68
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG1_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.056009 (rank : 1231)
Query Neighborhood Hits	479	Target Neighborhood Hits	176	Shared Neighborhood Hits	25
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.052819 (rank : 1321)
Query Neighborhood Hits	479	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG3_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.064312 (rank : 1080)
Query Neighborhood Hits	479	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.063443 (rank : 1093)
Query Neighborhood Hits	479	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.121673 (rank : 425)
Query Neighborhood Hits	479	Target Neighborhood Hits	242	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.090811 (rank : 782)
Query Neighborhood Hits	479	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.153534 (rank : 257)
Query Neighborhood Hits	479	Target Neighborhood Hits	376	Shared Neighborhood Hits	145
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.151753 (rank : 267)
Query Neighborhood Hits	479	Target Neighborhood Hits	394	Shared Neighborhood Hits	162
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.154587 (rank : 254)
Query Neighborhood Hits	479	Target Neighborhood Hits	347	Shared Neighborhood Hits	130
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.161920 (rank : 231)
Query Neighborhood Hits	479	Target Neighborhood Hits	396	Shared Neighborhood Hits	156
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.062105 (rank : 1113)
Query Neighborhood Hits	479	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.059576 (rank : 1158)
Query Neighborhood Hits	479	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.106666 (rank : 554)
Query Neighborhood Hits	479	Target Neighborhood Hits	235	Shared Neighborhood Hits	92
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.106615 (rank : 555)
Query Neighborhood Hits	479	Target Neighborhood Hits	234	Shared Neighborhood Hits	92
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.065415 (rank : 1070)
Query Neighborhood Hits	479	Target Neighborhood Hits	187	Shared Neighborhood Hits	41
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.064435 (rank : 1078)
Query Neighborhood Hits	479	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.063531 (rank : 1091)
Query Neighborhood Hits	479	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.068340 (rank : 1034)
Query Neighborhood Hits	479	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.102784 (rank : 602)
Query Neighborhood Hits	479	Target Neighborhood Hits	956	Shared Neighborhood Hits	214
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.097161 (rank : 697)
Query Neighborhood Hits	479	Target Neighborhood Hits	1244	Shared Neighborhood Hits	216
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.098701 (rank : 669)
Query Neighborhood Hits	479	Target Neighborhood Hits	1156	Shared Neighborhood Hits	233
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AVR2A_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.055182 (rank : 1247)
Query Neighborhood Hits	479	Target Neighborhood Hits	767	Shared Neighborhood Hits	58
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.055183 (rank : 1246)
Query Neighborhood Hits	479	Target Neighborhood Hits	767	Shared Neighborhood Hits	58
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.054951 (rank : 1257)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	59
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.055054 (rank : 1253)
Query Neighborhood Hits	479	Target Neighborhood Hits	749	Shared Neighborhood Hits	59
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AZI1_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.131701 (rank : 351)
Query Neighborhood Hits	479	Target Neighborhood Hits	990	Shared Neighborhood Hits	213
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BAIP2_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.072694 (rank : 985)
Query Neighborhood Hits	479	Target Neighborhood Hits	192	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.066341 (rank : 1055)
Query Neighborhood Hits	479	Target Neighborhood Hits	185	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAP29_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.056556 (rank : 1213)
Query Neighborhood Hits	479	Target Neighborhood Hits	362	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UHQ4, O95003	Gene names	BCAP29, BAP29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

BCAR1_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.085724 (rank : 845)
Query Neighborhood Hits	479	Target Neighborhood Hits	554	Shared Neighborhood Hits	104
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.091956 (rank : 766)
Query Neighborhood Hits	479	Target Neighborhood Hits	438	Shared Neighborhood Hits	100
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCN1_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.069424 (rank : 1026)
Query Neighborhood Hits	479	Target Neighborhood Hits	395	Shared Neighborhood Hits	137
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

BCN1_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.064285 (rank : 1081)
Query Neighborhood Hits	479	Target Neighborhood Hits	367	Shared Neighborhood Hits	125
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

BEGIN_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.051876 (rank : 1343)
Query Neighborhood Hits	479	Target Neighborhood Hits	454	Shared Neighborhood Hits	125
SwissProt Accessions	Q9BUH8, Q9NPU3, Q9P282	Gene names	BEGAIN, KIAA1446
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

BFSP1_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.068940 (rank : 1031)
Query Neighborhood Hits	479	Target Neighborhood Hits	508	Shared Neighborhood Hits	151
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

BI2L1_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.066455 (rank : 1054)
Query Neighborhood Hits	479	Target Neighborhood Hits	156	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BMPR2_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.061067 (rank : 1134)
Query Neighborhood Hits	479	Target Neighborhood Hits	736	Shared Neighborhood Hits	61
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.061036 (rank : 1136)
Query Neighborhood Hits	479	Target Neighborhood Hits	738	Shared Neighborhood Hits	62
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.076853 (rank : 937)
Query Neighborhood Hits	479	Target Neighborhood Hits	759	Shared Neighborhood Hits	58
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.076974 (rank : 934)
Query Neighborhood Hits	479	Target Neighborhood Hits	758	Shared Neighborhood Hits	58
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.080937 (rank : 888)
Query Neighborhood Hits	479	Target Neighborhood Hits	760	Shared Neighborhood Hits	60
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.080816 (rank : 890)
Query Neighborhood Hits	479	Target Neighborhood Hits	758	Shared Neighborhood Hits	60
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BPAEA_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.103611 (rank : 594)
Query Neighborhood Hits	479	Target Neighborhood Hits	1369	Shared Neighborhood Hits	228
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRAF1_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.089283 (rank : 801)
Query Neighborhood Hits	479	Target Neighborhood Hits	883	Shared Neighborhood Hits	70
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRAP_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.069889 (rank : 1015)
Query Neighborhood Hits	479	Target Neighborhood Hits	560	Shared Neighborhood Hits	138
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BRE1A_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.109561 (rank : 525)
Query Neighborhood Hits	479	Target Neighborhood Hits	1071	Shared Neighborhood Hits	213
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1B_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.091132 (rank : 776)
Query Neighborhood Hits	479	Target Neighborhood Hits	1040	Shared Neighborhood Hits	182
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.091243 (rank : 775)
Query Neighborhood Hits	479	Target Neighborhood Hits	970	Shared Neighborhood Hits	179
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

BRSK1_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.052014 (rank : 1336)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.053358 (rank : 1300)
Query Neighborhood Hits	479	Target Neighborhood Hits	897	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

C102B_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.120311 (rank : 434)
Query Neighborhood Hits	479	Target Neighborhood Hits	542	Shared Neighborhood Hits	179
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

CA065_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.088992 (rank : 807)
Query Neighborhood Hits	479	Target Neighborhood Hits	469	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CAF1A_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.107370 (rank : 542)
Query Neighborhood Hits	479	Target Neighborhood Hits	750	Shared Neighborhood Hits	165
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CAF1A_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.119273 (rank : 443)
Query Neighborhood Hits	479	Target Neighborhood Hits	736	Shared Neighborhood Hits	172
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CALD1_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.122487 (rank : 418)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	197
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CAR10_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.073736 (rank : 968)
Query Neighborhood Hits	479	Target Neighborhood Hits	569	Shared Neighborhood Hits	156
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CAR10_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.063841 (rank : 1089)
Query Neighborhood Hits	479	Target Neighborhood Hits	407	Shared Neighborhood Hits	134
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

CAR11_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.113851 (rank : 479)
Query Neighborhood Hits	479	Target Neighborhood Hits	690	Shared Neighborhood Hits	186
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.083543 (rank : 865)
Query Neighborhood Hits	479	Target Neighborhood Hits	526	Shared Neighborhood Hits	149
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

CASC5_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.055583 (rank : 1237)
Query Neighborhood Hits	479	Target Neighborhood Hits	376	Shared Neighborhood Hits	127
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

CASL_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.073562 (rank : 971)
Query Neighborhood Hits	479	Target Neighborhood Hits	259	Shared Neighborhood Hits	86
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CCAR1_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.052410 (rank : 1330)
Query Neighborhood Hits	479	Target Neighborhood Hits	444	Shared Neighborhood Hits	123
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

CCD11_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.120564 (rank : 432)
Query Neighborhood Hits	479	Target Neighborhood Hits	822	Shared Neighborhood Hits	190
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD11_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.110653 (rank : 507)
Query Neighborhood Hits	479	Target Neighborhood Hits	498	Shared Neighborhood Hits	152
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD13_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.112885 (rank : 487)
Query Neighborhood Hits	479	Target Neighborhood Hits	721	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD19_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.123532 (rank : 413)
Query Neighborhood Hits	479	Target Neighborhood Hits	639	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD21_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.110603 (rank : 508)
Query Neighborhood Hits	479	Target Neighborhood Hits	1228	Shared Neighborhood Hits	218
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.109450 (rank : 526)
Query Neighborhood Hits	479	Target Neighborhood Hits	1135	Shared Neighborhood Hits	211
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD22_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.056544 (rank : 1214)
Query Neighborhood Hits	479	Target Neighborhood Hits	242	Shared Neighborhood Hits	97
SwissProt Accessions	O60826	Gene names	CCDC22, CXorf37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CCD22_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.064845 (rank : 1076)
Query Neighborhood Hits	479	Target Neighborhood Hits	268	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CCD27_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.093439 (rank : 752)
Query Neighborhood Hits	479	Target Neighborhood Hits	594	Shared Neighborhood Hits	161
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD27_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.099413 (rank : 659)
Query Neighborhood Hits	479	Target Neighborhood Hits	461	Shared Neighborhood Hits	153
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD37_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.051013 (rank : 1386)
Query Neighborhood Hits	479	Target Neighborhood Hits	248	Shared Neighborhood Hits	94
SwissProt Accessions	Q494V2, Q494V1, Q494V4, Q8N838	Gene names	CCDC37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

CCD37_MOUSE
θ value	θ > 10 (rank : 607)	NC score	0.051994 (rank : 1338)
Query Neighborhood Hits	479	Target Neighborhood Hits	199	Shared Neighborhood Hits	76
SwissProt Accessions	Q80VN0, Q6AXD6	Gene names	Ccdc37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

CCD39_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.125772 (rank : 395)
Query Neighborhood Hits	479	Target Neighborhood Hits	868	Shared Neighborhood Hits	208
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD41_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.114352 (rank : 477)
Query Neighborhood Hits	479	Target Neighborhood Hits	1139	Shared Neighborhood Hits	206
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD42_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.069724 (rank : 1021)
Query Neighborhood Hits	479	Target Neighborhood Hits	284	Shared Neighborhood Hits	115
SwissProt Accessions	Q5SV66, Q8BNY1	Gene names	Ccdc42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CCD46_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.127270 (rank : 386)
Query Neighborhood Hits	479	Target Neighborhood Hits	1405	Shared Neighborhood Hits	248
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CCD62_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.117353 (rank : 455)
Query Neighborhood Hits	479	Target Neighborhood Hits	631	Shared Neighborhood Hits	185
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CCD91_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.108988 (rank : 530)
Query Neighborhood Hits	479	Target Neighborhood Hits	868	Shared Neighborhood Hits	193
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CCD93_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.084559 (rank : 858)
Query Neighborhood Hits	479	Target Neighborhood Hits	600	Shared Neighborhood Hits	153
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD93_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.070786 (rank : 1005)
Query Neighborhood Hits	479	Target Neighborhood Hits	362	Shared Neighborhood Hits	121
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD96_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.092677 (rank : 758)
Query Neighborhood Hits	479	Target Neighborhood Hits	595	Shared Neighborhood Hits	151
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCD96_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.095559 (rank : 726)
Query Neighborhood Hits	479	Target Neighborhood Hits	704	Shared Neighborhood Hits	167
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCDC6_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.110441 (rank : 510)
Query Neighborhood Hits	479	Target Neighborhood Hits	723	Shared Neighborhood Hits	178
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCDC7_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.089729 (rank : 793)
Query Neighborhood Hits	479	Target Neighborhood Hits	253	Shared Neighborhood Hits	99
SwissProt Accessions	Q96M83, Q8IVQ0, Q8NEQ0	Gene names	CCDC7
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 7.

CCHCR_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.119466 (rank : 439)
Query Neighborhood Hits	479	Target Neighborhood Hits	717	Shared Neighborhood Hits	176
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CCHCR_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.123402 (rank : 415)
Query Neighborhood Hits	479	Target Neighborhood Hits	932	Shared Neighborhood Hits	191
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CD2L1_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.057169 (rank : 1202)
Query Neighborhood Hits	479	Target Neighborhood Hits	1467	Shared Neighborhood Hits	169
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.057553 (rank : 1195)
Query Neighborhood Hits	479	Target Neighborhood Hits	1463	Shared Neighborhood Hits	173
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.054960 (rank : 1256)
Query Neighborhood Hits	479	Target Neighborhood Hits	1439	Shared Neighborhood Hits	162
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L5_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.051886 (rank : 1341)
Query Neighborhood Hits	479	Target Neighborhood Hits	987	Shared Neighborhood Hits	63
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.051823 (rank : 1347)
Query Neighborhood Hits	479	Target Neighborhood Hits	1011	Shared Neighborhood Hits	62
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.052846 (rank : 1320)
Query Neighborhood Hits	479	Target Neighborhood Hits	1275	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDC37_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.065586 (rank : 1066)
Query Neighborhood Hits	479	Target Neighborhood Hits	506	Shared Neighborhood Hits	124
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CDC37_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.057360 (rank : 1198)
Query Neighborhood Hits	479	Target Neighborhood Hits	359	Shared Neighborhood Hits	119
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CDR2_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.080690 (rank : 891)
Query Neighborhood Hits	479	Target Neighborhood Hits	404	Shared Neighborhood Hits	137
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

CDR2_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.094510 (rank : 737)
Query Neighborhood Hits	479	Target Neighborhood Hits	482	Shared Neighborhood Hits	150
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CE152_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.127513 (rank : 382)
Query Neighborhood Hits	479	Target Neighborhood Hits	976	Shared Neighborhood Hits	207
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CENPH_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.074635 (rank : 959)
Query Neighborhood Hits	479	Target Neighborhood Hits	335	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

CENPH_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.060464 (rank : 1144)
Query Neighborhood Hits	479	Target Neighborhood Hits	195	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

CENPJ_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.099832 (rank : 651)
Query Neighborhood Hits	479	Target Neighborhood Hits	721	Shared Neighborhood Hits	170
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CENPK_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.055791 (rank : 1233)
Query Neighborhood Hits	479	Target Neighborhood Hits	273	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BS16, Q9H4L0	Gene names	CENPK, ICEN37
Domain Architecture	No domain graphic available
Description	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33).

CENPU_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.051580 (rank : 1358)
Query Neighborhood Hits	479	Target Neighborhood Hits	289	Shared Neighborhood Hits	90
SwissProt Accessions	Q71F23, Q32Q71, Q9H5G1	Gene names	MLF1IP, CENPU, ICEN24, KLIP1
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (CENP-U(50)) (CENP-50) (Interphase centromere complex protein 24) (MLF1-interacting protein) (KSHV latent nuclear antigen-interacting protein 1).

CEP35_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.077461 (rank : 930)
Query Neighborhood Hits	479	Target Neighborhood Hits	811	Shared Neighborhood Hits	172
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CEP55_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.113272 (rank : 484)
Query Neighborhood Hits	479	Target Neighborhood Hits	504	Shared Neighborhood Hits	163
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

CEP57_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.094366 (rank : 738)
Query Neighborhood Hits	479	Target Neighborhood Hits	576	Shared Neighborhood Hits	185
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

CEP57_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.090820 (rank : 781)
Query Neighborhood Hits	479	Target Neighborhood Hits	580	Shared Neighborhood Hits	177
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CEP70_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.100027 (rank : 648)
Query Neighborhood Hits	479	Target Neighborhood Hits	432	Shared Neighborhood Hits	154
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

CEP72_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.050629 (rank : 1399)
Query Neighborhood Hits	479	Target Neighborhood Hits	381	Shared Neighborhood Hits	106
SwissProt Accessions	Q9D3R3, Q8BM53, Q9D0B7	Gene names	Cep72
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.119372 (rank : 440)
Query Neighborhood Hits	479	Target Neighborhood Hits	1270	Shared Neighborhood Hits	227
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CF152_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.097999 (rank : 680)
Query Neighborhood Hits	479	Target Neighborhood Hits	704	Shared Neighborhood Hits	185
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CF152_MOUSE
θ value	θ > 10 (rank : 646)	NC score	0.089939 (rank : 792)
Query Neighborhood Hits	479	Target Neighborhood Hits	597	Shared Neighborhood Hits	160
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CF182_HUMAN
θ value	θ > 10 (rank : 647)	NC score	0.085518 (rank : 847)
Query Neighborhood Hits	479	Target Neighborhood Hits	474	Shared Neighborhood Hits	156
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

CF182_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.091991 (rank : 765)
Query Neighborhood Hits	479	Target Neighborhood Hits	551	Shared Neighborhood Hits	169
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CI096_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.063394 (rank : 1094)
Query Neighborhood Hits	479	Target Neighborhood Hits	821	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CING_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.140156 (rank : 304)
Query Neighborhood Hits	479	Target Neighborhood Hits	1275	Shared Neighborhood Hits	232
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CJ068_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.066070 (rank : 1059)
Query Neighborhood Hits	479	Target Neighborhood Hits	316	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

CJ118_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.138774 (rank : 307)
Query Neighborhood Hits	479	Target Neighborhood Hits	937	Shared Neighborhood Hits	213
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

CJ118_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.132185 (rank : 343)
Query Neighborhood Hits	479	Target Neighborhood Hits	1132	Shared Neighborhood Hits	218
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CKAP4_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.107080 (rank : 547)
Query Neighborhood Hits	479	Target Neighborhood Hits	592	Shared Neighborhood Hits	162
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CLC4F_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.075038 (rank : 952)
Query Neighborhood Hits	479	Target Neighborhood Hits	513	Shared Neighborhood Hits	130
SwissProt Accessions	Q8N1N0	Gene names	CLEC4F, CLECSF13
Domain Architecture	No domain graphic available
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13).

CLC4F_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.058877 (rank : 1172)
Query Neighborhood Hits	479	Target Neighborhood Hits	572	Shared Neighborhood Hits	135
SwissProt Accessions	P70194, Q8BLZ8	Gene names	Clec4f, Clecsf13, Kclr
Domain Architecture
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor).

CLUA1_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.061671 (rank : 1121)
Query Neighborhood Hits	479	Target Neighborhood Hits	261	Shared Neighborhood Hits	108
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CM007_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.054563 (rank : 1270)
Query Neighborhood Hits	479	Target Neighborhood Hits	422	Shared Neighborhood Hits	108
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

CNTRB_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.097220 (rank : 694)
Query Neighborhood Hits	479	Target Neighborhood Hits	690	Shared Neighborhood Hits	173
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CNTRB_MOUSE
θ value	θ > 10 (rank : 660)	NC score	0.096746 (rank : 701)
Query Neighborhood Hits	479	Target Neighborhood Hits	1029	Shared Neighborhood Hits	193
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

COVA1_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.081215 (rank : 885)
Query Neighborhood Hits	479	Target Neighborhood Hits	416	Shared Neighborhood Hits	134
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

COVA1_MOUSE
θ value	θ > 10 (rank : 662)	NC score	0.073397 (rank : 973)
Query Neighborhood Hits	479	Target Neighborhood Hits	335	Shared Neighborhood Hits	103
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

CP250_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.133534 (rank : 334)
Query Neighborhood Hits	479	Target Neighborhood Hits	1805	Shared Neighborhood Hits	255
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CR034_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.122437 (rank : 420)
Query Neighborhood Hits	479	Target Neighborhood Hits	538	Shared Neighborhood Hits	179
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

CRCM_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.093874 (rank : 748)
Query Neighborhood Hits	479	Target Neighborhood Hits	520	Shared Neighborhood Hits	164
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

CROCC_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.122326 (rank : 422)
Query Neighborhood Hits	479	Target Neighborhood Hits	1409	Shared Neighborhood Hits	234
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CROCC_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.117504 (rank : 453)
Query Neighborhood Hits	479	Target Neighborhood Hits	1460	Shared Neighborhood Hits	231
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CROP_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.059052 (rank : 1168)
Query Neighborhood Hits	479	Target Neighborhood Hits	402	Shared Neighborhood Hits	107
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

CROP_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.056533 (rank : 1215)
Query Neighborhood Hits	479	Target Neighborhood Hits	403	Shared Neighborhood Hits	106
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

CSF1R_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.099498 (rank : 657)
Query Neighborhood Hits	479	Target Neighborhood Hits	943	Shared Neighborhood Hits	58
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.096672 (rank : 704)
Query Neighborhood Hits	479	Target Neighborhood Hits	983	Shared Neighborhood Hits	58
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CT032_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.089683 (rank : 794)
Query Neighborhood Hits	479	Target Neighborhood Hits	235	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CT096_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.086188 (rank : 840)
Query Neighborhood Hits	479	Target Neighborhood Hits	438	Shared Neighborhood Hits	132
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

CU013_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.079071 (rank : 912)
Query Neighborhood Hits	479	Target Neighborhood Hits	405	Shared Neighborhood Hits	124
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

CUTL2_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.056616 (rank : 1212)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	134
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CYLC1_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.056451 (rank : 1218)
Query Neighborhood Hits	479	Target Neighborhood Hits	408	Shared Neighborhood Hits	75
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

CYLN2_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.110537 (rank : 509)
Query Neighborhood Hits	479	Target Neighborhood Hits	1004	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CYLN2_MOUSE
θ value	θ > 10 (rank : 678)	NC score	0.114844 (rank : 472)
Query Neighborhood Hits	479	Target Neighborhood Hits	1002	Shared Neighborhood Hits	212
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

CYTSA_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.123190 (rank : 416)
Query Neighborhood Hits	479	Target Neighborhood Hits	1138	Shared Neighborhood Hits	224
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.121296 (rank : 427)
Query Neighborhood Hits	479	Target Neighborhood Hits	1104	Shared Neighborhood Hits	222
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DAPK3_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.050172 (rank : 1423)
Query Neighborhood Hits	479	Target Neighborhood Hits	945	Shared Neighborhood Hits	105
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DDEF1_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.075642 (rank : 946)
Query Neighborhood Hits	479	Target Neighborhood Hits	592	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.077777 (rank : 924)
Query Neighborhood Hits	479	Target Neighborhood Hits	599	Shared Neighborhood Hits	116
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 684)	NC score	0.075069 (rank : 951)
Query Neighborhood Hits	479	Target Neighborhood Hits	625	Shared Neighborhood Hits	108
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDR1_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.102693 (rank : 605)
Query Neighborhood Hits	479	Target Neighborhood Hits	819	Shared Neighborhood Hits	60
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.102757 (rank : 604)
Query Neighborhood Hits	479	Target Neighborhood Hits	818	Shared Neighborhood Hits	60
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.099163 (rank : 661)
Query Neighborhood Hits	479	Target Neighborhood Hits	818	Shared Neighborhood Hits	60
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.098769 (rank : 666)
Query Neighborhood Hits	479	Target Neighborhood Hits	813	Shared Neighborhood Hits	58
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DIAP1_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.052678 (rank : 1325)
Query Neighborhood Hits	479	Target Neighborhood Hits	839	Shared Neighborhood Hits	162
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

DLG5_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.091781 (rank : 767)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	211
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DMD_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.087293 (rank : 826)
Query Neighborhood Hits	479	Target Neighborhood Hits	1135	Shared Neighborhood Hits	207
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DOCK1_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.052442 (rank : 1329)
Query Neighborhood Hits	479	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DREB_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.071719 (rank : 994)
Query Neighborhood Hits	479	Target Neighborhood Hits	450	Shared Neighborhood Hits	116
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DREB_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.085544 (rank : 846)
Query Neighborhood Hits	479	Target Neighborhood Hits	446	Shared Neighborhood Hits	112
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DUET_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.056433 (rank : 1220)
Query Neighborhood Hits	479	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYHC_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.060793 (rank : 1139)
Query Neighborhood Hits	479	Target Neighborhood Hits	733	Shared Neighborhood Hits	170
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.060928 (rank : 1138)
Query Neighborhood Hits	479	Target Neighborhood Hits	729	Shared Neighborhood Hits	172
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYNA_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.105579 (rank : 569)
Query Neighborhood Hits	479	Target Neighborhood Hits	1194	Shared Neighborhood Hits	212
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.105073 (rank : 574)
Query Neighborhood Hits	479	Target Neighborhood Hits	1084	Shared Neighborhood Hits	205
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

E2AK1_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.052011 (rank : 1337)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.053086 (rank : 1312)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	63
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.056870 (rank : 1207)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	60
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.051652 (rank : 1354)
Query Neighborhood Hits	479	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.051191 (rank : 1382)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ECT2_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.066705 (rank : 1048)
Query Neighborhood Hits	479	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.068072 (rank : 1036)
Query Neighborhood Hits	479	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EEA1_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.126825 (rank : 389)
Query Neighborhood Hits	479	Target Neighborhood Hits	1637	Shared Neighborhood Hits	241
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.094688 (rank : 736)
Query Neighborhood Hits	479	Target Neighborhood Hits	348	Shared Neighborhood Hits	93
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EGFR_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.099157 (rank : 662)
Query Neighborhood Hits	479	Target Neighborhood Hits	939	Shared Neighborhood Hits	60
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.099155 (rank : 663)
Query Neighborhood Hits	479	Target Neighborhood Hits	927	Shared Neighborhood Hits	60
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ENAH_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.077591 (rank : 925)
Query Neighborhood Hits	479	Target Neighborhood Hits	784	Shared Neighborhood Hits	154
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

EP15R_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.104393 (rank : 584)
Query Neighborhood Hits	479	Target Neighborhood Hits	1083	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.114786 (rank : 473)
Query Neighborhood Hits	479	Target Neighborhood Hits	1021	Shared Neighborhood Hits	218
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.098492 (rank : 671)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	186
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPHA1_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.099178 (rank : 660)
Query Neighborhood Hits	479	Target Neighborhood Hits	997	Shared Neighborhood Hits	64
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.100103 (rank : 646)
Query Neighborhood Hits	479	Target Neighborhood Hits	958	Shared Neighborhood Hits	63
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.097172 (rank : 696)
Query Neighborhood Hits	479	Target Neighborhood Hits	1021	Shared Neighborhood Hits	63
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.097377 (rank : 692)
Query Neighborhood Hits	479	Target Neighborhood Hits	1020	Shared Neighborhood Hits	63
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.093833 (rank : 749)
Query Neighborhood Hits	479	Target Neighborhood Hits	1005	Shared Neighborhood Hits	59
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.094283 (rank : 739)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	62
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.096693 (rank : 702)
Query Neighborhood Hits	479	Target Neighborhood Hits	975	Shared Neighborhood Hits	63
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.096409 (rank : 710)
Query Neighborhood Hits	479	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.095256 (rank : 730)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	63
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.098747 (rank : 667)
Query Neighborhood Hits	479	Target Neighborhood Hits	950	Shared Neighborhood Hits	61
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.100389 (rank : 637)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.100170 (rank : 644)
Query Neighborhood Hits	479	Target Neighborhood Hits	946	Shared Neighborhood Hits	62
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.094060 (rank : 741)
Query Neighborhood Hits	479	Target Neighborhood Hits	1053	Shared Neighborhood Hits	63
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.093955 (rank : 745)
Query Neighborhood Hits	479	Target Neighborhood Hits	1025	Shared Neighborhood Hits	63
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.096803 (rank : 699)
Query Neighborhood Hits	479	Target Neighborhood Hits	956	Shared Neighborhood Hits	64
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.097175 (rank : 695)
Query Neighborhood Hits	479	Target Neighborhood Hits	969	Shared Neighborhood Hits	65
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.103115 (rank : 600)
Query Neighborhood Hits	479	Target Neighborhood Hits	960	Shared Neighborhood Hits	61
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.094904 (rank : 734)
Query Neighborhood Hits	479	Target Neighborhood Hits	988	Shared Neighborhood Hits	62
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.095891 (rank : 719)
Query Neighborhood Hits	479	Target Neighborhood Hits	983	Shared Neighborhood Hits	63
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.095853 (rank : 720)
Query Neighborhood Hits	479	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.095560 (rank : 724)
Query Neighborhood Hits	479	Target Neighborhood Hits	996	Shared Neighborhood Hits	63
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.095561 (rank : 723)
Query Neighborhood Hits	479	Target Neighborhood Hits	996	Shared Neighborhood Hits	62
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.095980 (rank : 718)
Query Neighborhood Hits	479	Target Neighborhood Hits	1056	Shared Neighborhood Hits	63
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.095383 (rank : 728)
Query Neighborhood Hits	479	Target Neighborhood Hits	1013	Shared Neighborhood Hits	63
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.101720 (rank : 615)
Query Neighborhood Hits	479	Target Neighborhood Hits	912	Shared Neighborhood Hits	61
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.101157 (rank : 623)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	61
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPS8_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.073760 (rank : 967)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.078113 (rank : 921)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERBB2_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.101391 (rank : 617)
Query Neighborhood Hits	479	Target Neighborhood Hits	1073	Shared Neighborhood Hits	63
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.101350 (rank : 618)
Query Neighborhood Hits	479	Target Neighborhood Hits	918	Shared Neighborhood Hits	59
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.102403 (rank : 606)
Query Neighborhood Hits	479	Target Neighborhood Hits	918	Shared Neighborhood Hits	60
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.102147 (rank : 612)
Query Neighborhood Hits	479	Target Neighborhood Hits	898	Shared Neighborhood Hits	59
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.101214 (rank : 619)
Query Neighborhood Hits	479	Target Neighborhood Hits	910	Shared Neighborhood Hits	60
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.084199 (rank : 864)
Query Neighborhood Hits	479	Target Neighborhood Hits	162	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.077196 (rank : 933)
Query Neighborhood Hits	479	Target Neighborhood Hits	143	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.095233 (rank : 731)
Query Neighborhood Hits	479	Target Neighborhood Hits	193	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.095762 (rank : 721)
Query Neighborhood Hits	479	Target Neighborhood Hits	169	Shared Neighborhood Hits	83
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.110134 (rank : 513)
Query Neighborhood Hits	479	Target Neighborhood Hits	206	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.104666 (rank : 581)
Query Neighborhood Hits	479	Target Neighborhood Hits	168	Shared Neighborhood Hits	85
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EVPL_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.118708 (rank : 447)
Query Neighborhood Hits	479	Target Neighborhood Hits	952	Shared Neighborhood Hits	214
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

EZRI_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.081500 (rank : 884)
Query Neighborhood Hits	479	Target Neighborhood Hits	663	Shared Neighborhood Hits	177
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.082064 (rank : 879)
Query Neighborhood Hits	479	Target Neighborhood Hits	693	Shared Neighborhood Hits	194
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FA50A_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.052550 (rank : 1327)
Query Neighborhood Hits	479	Target Neighborhood Hits	264	Shared Neighborhood Hits	100
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

FA50A_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.058781 (rank : 1175)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	111
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

FAK1_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.100552 (rank : 636)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.100624 (rank : 632)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	60
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.104786 (rank : 579)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	65
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.104573 (rank : 583)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FGD3_MOUSE
θ value	θ > 10 (rank : 763)	NC score	0.050557 (rank : 1404)
Query Neighborhood Hits	479	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.050266 (rank : 1415)
Query Neighborhood Hits	479	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.051221 (rank : 1378)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGFR1_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.089606 (rank : 797)
Query Neighborhood Hits	479	Target Neighborhood Hits	1069	Shared Neighborhood Hits	58
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.089621 (rank : 796)
Query Neighborhood Hits	479	Target Neighborhood Hits	1068	Shared Neighborhood Hits	58
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.090598 (rank : 787)
Query Neighborhood Hits	479	Target Neighborhood Hits	1062	Shared Neighborhood Hits	58
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.091030 (rank : 777)
Query Neighborhood Hits	479	Target Neighborhood Hits	1062	Shared Neighborhood Hits	58
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.091017 (rank : 778)
Query Neighborhood Hits	479	Target Neighborhood Hits	1042	Shared Neighborhood Hits	58
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.090283 (rank : 790)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	58
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.092398 (rank : 761)
Query Neighborhood Hits	479	Target Neighborhood Hits	1037	Shared Neighborhood Hits	58
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 773)	NC score	0.093990 (rank : 742)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	55
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLIP1_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.127429 (rank : 384)
Query Neighborhood Hits	479	Target Neighborhood Hits	1405	Shared Neighborhood Hits	237
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.127467 (rank : 383)
Query Neighborhood Hits	479	Target Neighborhood Hits	1176	Shared Neighborhood Hits	212
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLT3_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.101185 (rank : 621)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	60
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.101589 (rank : 616)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	58
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FYCO1_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.119330 (rank : 441)
Query Neighborhood Hits	479	Target Neighborhood Hits	1149	Shared Neighborhood Hits	215
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

GAS7_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.060570 (rank : 1141)
Query Neighborhood Hits	479	Target Neighborhood Hits	258	Shared Neighborhood Hits	89
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.059612 (rank : 1157)
Query Neighborhood Hits	479	Target Neighborhood Hits	259	Shared Neighborhood Hits	90
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS8_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.114514 (rank : 475)
Query Neighborhood Hits	479	Target Neighborhood Hits	819	Shared Neighborhood Hits	190
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GBP1_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.061084 (rank : 1132)
Query Neighborhood Hits	479	Target Neighborhood Hits	339	Shared Neighborhood Hits	119
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

GBP2_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.063089 (rank : 1097)
Query Neighborhood Hits	479	Target Neighborhood Hits	349	Shared Neighborhood Hits	122
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

GBP4_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.080248 (rank : 895)
Query Neighborhood Hits	479	Target Neighborhood Hits	484	Shared Neighborhood Hits	154
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

GCC1_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.106463 (rank : 560)
Query Neighborhood Hits	479	Target Neighborhood Hits	887	Shared Neighborhood Hits	199
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCC1_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.106714 (rank : 552)
Query Neighborhood Hits	479	Target Neighborhood Hits	777	Shared Neighborhood Hits	191
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCC2_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.132125 (rank : 344)
Query Neighborhood Hits	479	Target Neighborhood Hits	1619	Shared Neighborhood Hits	251
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GCP60_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.066070 (rank : 1060)
Query Neighborhood Hits	479	Target Neighborhood Hits	419	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

GCP60_MOUSE
θ value	θ > 10 (rank : 789)	NC score	0.050554 (rank : 1405)
Query Neighborhood Hits	479	Target Neighborhood Hits	395	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

GFAP_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.059697 (rank : 1154)
Query Neighborhood Hits	479	Target Neighborhood Hits	723	Shared Neighborhood Hits	188
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

GFAP_MOUSE
θ value	θ > 10 (rank : 791)	NC score	0.057793 (rank : 1192)
Query Neighborhood Hits	479	Target Neighborhood Hits	725	Shared Neighborhood Hits	191
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

GLE1_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.054727 (rank : 1264)
Query Neighborhood Hits	479	Target Neighborhood Hits	445	Shared Neighborhood Hits	114
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

GLE1_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.063464 (rank : 1092)
Query Neighborhood Hits	479	Target Neighborhood Hits	504	Shared Neighborhood Hits	125
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

GNRP_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.064866 (rank : 1075)
Query Neighborhood Hits	479	Target Neighborhood Hits	239	Shared Neighborhood Hits	61
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.061808 (rank : 1119)
Query Neighborhood Hits	479	Target Neighborhood Hits	191	Shared Neighborhood Hits	32
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GOG8A_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.100854 (rank : 627)
Query Neighborhood Hits	479	Target Neighborhood Hits	635	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

GOGA2_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.113664 (rank : 481)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	192
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA2_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.125960 (rank : 394)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	214
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GOGA3_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.119326 (rank : 442)
Query Neighborhood Hits	479	Target Neighborhood Hits	1317	Shared Neighborhood Hits	229
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA5_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.112517 (rank : 490)
Query Neighborhood Hits	479	Target Neighborhood Hits	1434	Shared Neighborhood Hits	235
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GOGA6_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.140080 (rank : 305)
Query Neighborhood Hits	479	Target Neighborhood Hits	1007	Shared Neighborhood Hits	220
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GP73_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.065641 (rank : 1065)
Query Neighborhood Hits	479	Target Neighborhood Hits	506	Shared Neighborhood Hits	118
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

GRAP1_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.132548 (rank : 340)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	208
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

GRAP1_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.131970 (rank : 347)
Query Neighborhood Hits	479	Target Neighborhood Hits	1234	Shared Neighborhood Hits	224
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GRB10_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.148360 (rank : 277)
Query Neighborhood Hits	479	Target Neighborhood Hits	147	Shared Neighborhood Hits	93
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.144921 (rank : 290)
Query Neighborhood Hits	479	Target Neighborhood Hits	156	Shared Neighborhood Hits	94
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.191935 (rank : 182)
Query Neighborhood Hits	479	Target Neighborhood Hits	137	Shared Neighborhood Hits	96
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.197720 (rank : 175)
Query Neighborhood Hits	479	Target Neighborhood Hits	149	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.172703 (rank : 216)
Query Neighborhood Hits	479	Target Neighborhood Hits	156	Shared Neighborhood Hits	98
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRP3_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.073422 (rank : 972)
Query Neighborhood Hits	479	Target Neighborhood Hits	131	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GUC2C_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.087973 (rank : 822)
Query Neighborhood Hits	479	Target Neighborhood Hits	624	Shared Neighborhood Hits	51
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.077849 (rank : 923)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	56
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.077465 (rank : 929)
Query Neighborhood Hits	479	Target Neighborhood Hits	692	Shared Neighborhood Hits	54
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.091254 (rank : 774)
Query Neighborhood Hits	479	Target Neighborhood Hits	740	Shared Neighborhood Hits	60
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.077308 (rank : 931)
Query Neighborhood Hits	479	Target Neighborhood Hits	644	Shared Neighborhood Hits	48
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HAP1_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.107629 (rank : 539)
Query Neighborhood Hits	479	Target Neighborhood Hits	606	Shared Neighborhood Hits	158
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

HAP1_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.057969 (rank : 1188)
Query Neighborhood Hits	479	Target Neighborhood Hits	388	Shared Neighborhood Hits	108
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

HAPIP_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.056495 (rank : 1216)
Query Neighborhood Hits	479	Target Neighborhood Hits	350	Shared Neighborhood Hits	115
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCLS1_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.157296 (rank : 243)
Query Neighborhood Hits	479	Target Neighborhood Hits	358	Shared Neighborhood Hits	104
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.162662 (rank : 228)
Query Neighborhood Hits	479	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HIP1R_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.096363 (rank : 712)
Query Neighborhood Hits	479	Target Neighborhood Hits	809	Shared Neighborhood Hits	198
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

HIP1R_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.103521 (rank : 595)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	201
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

HIP1_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.094810 (rank : 735)
Query Neighborhood Hits	479	Target Neighborhood Hits	1016	Shared Neighborhood Hits	214
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HOME1_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.092849 (rank : 757)
Query Neighborhood Hits	479	Target Neighborhood Hits	564	Shared Neighborhood Hits	158
SwissProt Accessions	Q86YM7, O96003, Q86YM5	Gene names	HOMER1, SYN47
Domain Architecture
Description	Homer protein homolog 1.

HOME1_MOUSE
θ value	θ > 10 (rank : 825)	NC score	0.090866 (rank : 780)
Query Neighborhood Hits	479	Target Neighborhood Hits	630	Shared Neighborhood Hits	167
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

HOME2_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.105064 (rank : 575)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NSB8, O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7	Gene names	HOMER2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin).

HOME2_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.109926 (rank : 518)
Query Neighborhood Hits	479	Target Neighborhood Hits	882	Shared Neighborhood Hits	193
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

HOOK1_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.124453 (rank : 408)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	217
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

HOOK2_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.106298 (rank : 561)
Query Neighborhood Hits	479	Target Neighborhood Hits	714	Shared Neighborhood Hits	177
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

HOOK2_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.115143 (rank : 471)
Query Neighborhood Hits	479	Target Neighborhood Hits	736	Shared Neighborhood Hits	188
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

IASPP_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.088246 (rank : 818)
Query Neighborhood Hits	479	Target Neighborhood Hits	688	Shared Neighborhood Hits	101
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.082104 (rank : 878)
Query Neighborhood Hits	479	Target Neighborhood Hits	1024	Shared Neighborhood Hits	117
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ICK_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.054219 (rank : 1282)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 834)	NC score	0.054373 (rank : 1276)
Query Neighborhood Hits	479	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IDLC_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.053125 (rank : 1311)
Query Neighborhood Hits	479	Target Neighborhood Hits	348	Shared Neighborhood Hits	107
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

IF2P_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.090611 (rank : 786)
Query Neighborhood Hits	479	Target Neighborhood Hits	889	Shared Neighborhood Hits	161
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IFT81_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.114117 (rank : 478)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	200
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IFT81_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.112336 (rank : 492)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	191
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IGF1R_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.101033 (rank : 625)
Query Neighborhood Hits	479	Target Neighborhood Hits	977	Shared Neighborhood Hits	60
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.101168 (rank : 622)
Query Neighborhood Hits	479	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IKKA_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.055194 (rank : 1245)
Query Neighborhood Hits	479	Target Neighborhood Hits	863	Shared Neighborhood Hits	63
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.055114 (rank : 1251)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	68
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.057110 (rank : 1203)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	110
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.055570 (rank : 1238)
Query Neighborhood Hits	479	Target Neighborhood Hits	984	Shared Neighborhood Hits	110
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.050949 (rank : 1389)
Query Neighborhood Hits	479	Target Neighborhood Hits	837	Shared Neighborhood Hits	66
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.052729 (rank : 1323)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ILK1_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.085970 (rank : 843)
Query Neighborhood Hits	479	Target Neighborhood Hits	857	Shared Neighborhood Hits	62
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.085178 (rank : 851)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	62
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.086897 (rank : 831)
Query Neighborhood Hits	479	Target Neighborhood Hits	858	Shared Neighborhood Hits	62
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

IMMT_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.078199 (rank : 919)
Query Neighborhood Hits	479	Target Neighborhood Hits	494	Shared Neighborhood Hits	148
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

IMMT_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.058045 (rank : 1185)
Query Neighborhood Hits	479	Target Neighborhood Hits	326	Shared Neighborhood Hits	114
SwissProt Accessions	Q8CAQ8, Q66JS4, Q7TNE2, Q8C7V1, Q8CCI0, Q8CDA8, Q9D9F6	Gene names	Immt
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin).

INCE_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.133586 (rank : 331)
Query Neighborhood Hits	479	Target Neighborhood Hits	978	Shared Neighborhood Hits	201
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INSRR_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.100173 (rank : 643)
Query Neighborhood Hits	479	Target Neighborhood Hits	950	Shared Neighborhood Hits	59
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.100241 (rank : 641)
Query Neighborhood Hits	479	Target Neighborhood Hits	961	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.098741 (rank : 668)
Query Neighborhood Hits	479	Target Neighborhood Hits	963	Shared Neighborhood Hits	58
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.098323 (rank : 673)
Query Neighborhood Hits	479	Target Neighborhood Hits	968	Shared Neighborhood Hits	59
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INVO_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.106912 (rank : 550)
Query Neighborhood Hits	479	Target Neighborhood Hits	636	Shared Neighborhood Hits	153
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

INVO_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.067682 (rank : 1039)
Query Neighborhood Hits	479	Target Neighborhood Hits	474	Shared Neighborhood Hits	106
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

IRAK1_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.074798 (rank : 957)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.079672 (rank : 902)
Query Neighborhood Hits	479	Target Neighborhood Hits	784	Shared Neighborhood Hits	59
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.067113 (rank : 1043)
Query Neighborhood Hits	479	Target Neighborhood Hits	714	Shared Neighborhood Hits	51
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.077587 (rank : 926)
Query Neighborhood Hits	479	Target Neighborhood Hits	644	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.080193 (rank : 896)
Query Neighborhood Hits	479	Target Neighborhood Hits	628	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.074732 (rank : 958)
Query Neighborhood Hits	479	Target Neighborhood Hits	816	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 865)	NC score	0.072340 (rank : 988)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

JAK1_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.090800 (rank : 783)
Query Neighborhood Hits	479	Target Neighborhood Hits	858	Shared Neighborhood Hits	64
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.091254 (rank : 773)
Query Neighborhood Hits	479	Target Neighborhood Hits	854	Shared Neighborhood Hits	65
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.086649 (rank : 836)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	63
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 869)	NC score	0.087109 (rank : 828)
Query Neighborhood Hits	479	Target Neighborhood Hits	839	Shared Neighborhood Hits	63
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.089467 (rank : 799)
Query Neighborhood Hits	479	Target Neighborhood Hits	827	Shared Neighborhood Hits	58
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 871)	NC score	0.086595 (rank : 837)
Query Neighborhood Hits	479	Target Neighborhood Hits	821	Shared Neighborhood Hits	58
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JIP3_HUMAN
θ value	θ > 10 (rank : 872)	NC score	0.061844 (rank : 1118)
Query Neighborhood Hits	479	Target Neighborhood Hits	1039	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

JIP3_MOUSE
θ value	θ > 10 (rank : 873)	NC score	0.059937 (rank : 1152)
Query Neighborhood Hits	479	Target Neighborhood Hits	759	Shared Neighborhood Hits	175
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

K0494_HUMAN
θ value	θ > 10 (rank : 874)	NC score	0.057954 (rank : 1189)
Query Neighborhood Hits	479	Target Neighborhood Hits	230	Shared Neighborhood Hits	81
SwissProt Accessions	O75071	Gene names	KIAA0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

K0494_MOUSE
θ value	θ > 10 (rank : 875)	NC score	0.055238 (rank : 1244)
Query Neighborhood Hits	479	Target Neighborhood Hits	241	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BGQ6, Q3TQN6, Q8BJV7, Q8C0R1	Gene names	Kiaa0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

K0552_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.076002 (rank : 943)
Query Neighborhood Hits	479	Target Neighborhood Hits	442	Shared Neighborhood Hits	133
SwissProt Accessions	O60299	Gene names	KIAA0552
Domain Architecture
Description	Protein KIAA0552.

K0999_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.051206 (rank : 1381)
Query Neighborhood Hits	479	Target Neighborhood Hits	899	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.051367 (rank : 1367)
Query Neighborhood Hits	479	Target Neighborhood Hits	931	Shared Neighborhood Hits	63
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K1688_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.209671 (rank : 150)
Query Neighborhood Hits	479	Target Neighborhood Hits	217	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

K1688_MOUSE
θ value	θ > 10 (rank : 880)	NC score	0.216979 (rank : 141)
Query Neighborhood Hits	479	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K2C4_MOUSE
θ value	θ > 10 (rank : 881)	NC score	0.050275 (rank : 1414)
Query Neighborhood Hits	479	Target Neighborhood Hits	521	Shared Neighborhood Hits	161
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

K2C8_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.052257 (rank : 1332)
Query Neighborhood Hits	479	Target Neighborhood Hits	593	Shared Neighborhood Hits	167
SwissProt Accessions	P05787, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q96J60	Gene names	KRT8, CYK8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8).

K2C8_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.051717 (rank : 1351)
Query Neighborhood Hits	479	Target Neighborhood Hits	576	Shared Neighborhood Hits	159
SwissProt Accessions	P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519	Gene names	Krt8, Krt2-8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Cytokeratin endo A).

KC1D_HUMAN
θ value	θ > 10 (rank : 884)	NC score	0.053303 (rank : 1305)
Query Neighborhood Hits	479	Target Neighborhood Hits	737	Shared Neighborhood Hits	57
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 885)	NC score	0.053298 (rank : 1306)
Query Neighborhood Hits	479	Target Neighborhood Hits	737	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 886)	NC score	0.051415 (rank : 1364)
Query Neighborhood Hits	479	Target Neighborhood Hits	732	Shared Neighborhood Hits	56
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 887)	NC score	0.051420 (rank : 1363)
Query Neighborhood Hits	479	Target Neighborhood Hits	728	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KI21A_HUMAN
θ value	θ > 10 (rank : 888)	NC score	0.074621 (rank : 960)
Query Neighborhood Hits	479	Target Neighborhood Hits	1543	Shared Neighborhood Hits	226
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

KI21B_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.057999 (rank : 1187)
Query Neighborhood Hits	479	Target Neighborhood Hits	1017	Shared Neighborhood Hits	193
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

KI21B_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.058749 (rank : 1176)
Query Neighborhood Hits	479	Target Neighborhood Hits	997	Shared Neighborhood Hits	195
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

KIF11_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.061376 (rank : 1130)
Query Neighborhood Hits	479	Target Neighborhood Hits	583	Shared Neighborhood Hits	166
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

KIF14_HUMAN
θ value	θ > 10 (rank : 892)	NC score	0.051313 (rank : 1374)
Query Neighborhood Hits	479	Target Neighborhood Hits	732	Shared Neighborhood Hits	171
SwissProt Accessions	Q15058	Gene names	KIF14, KIAA0042
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF14.

KIF23_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.058562 (rank : 1178)
Query Neighborhood Hits	479	Target Neighborhood Hits	618	Shared Neighborhood Hits	163
SwissProt Accessions	Q02241	Gene names	KIF23, KNSL5, MKLP1
Domain Architecture
Description	Kinesin-like protein KIF23 (Mitotic kinesin-like protein 1) (Kinesin- like protein 5).

KIF3A_MOUSE
θ value	θ > 10 (rank : 894)	NC score	0.057028 (rank : 1204)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	170
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3B_HUMAN
θ value	θ > 10 (rank : 895)	NC score	0.058818 (rank : 1173)
Query Neighborhood Hits	479	Target Neighborhood Hits	540	Shared Neighborhood Hits	161
SwissProt Accessions	O15066	Gene names	KIF3B, KIAA0359
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) (HH0048).

KIF4A_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.088889 (rank : 809)
Query Neighborhood Hits	479	Target Neighborhood Hits	1159	Shared Neighborhood Hits	205
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF4A_MOUSE
θ value	θ > 10 (rank : 897)	NC score	0.080345 (rank : 894)
Query Neighborhood Hits	479	Target Neighborhood Hits	1033	Shared Neighborhood Hits	203
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF5A_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.084437 (rank : 861)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	205
SwissProt Accessions	Q12840, Q4LE26	Gene names	KIF5A, NKHC1
Domain Architecture
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

KIF5A_MOUSE
θ value	θ > 10 (rank : 899)	NC score	0.076319 (rank : 940)
Query Neighborhood Hits	479	Target Neighborhood Hits	859	Shared Neighborhood Hits	204
SwissProt Accessions	P33175, Q5DTP1, Q6PDY7, Q9Z2F9	Gene names	Kif5a, Kiaa4086, Kif5, Nkhc1
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

KIF5C_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.088729 (rank : 810)
Query Neighborhood Hits	479	Target Neighborhood Hits	974	Shared Neighborhood Hits	221
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIF5C_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.090620 (rank : 785)
Query Neighborhood Hits	479	Target Neighborhood Hits	1040	Shared Neighborhood Hits	228
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIFC1_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.061576 (rank : 1123)
Query Neighborhood Hits	479	Target Neighborhood Hits	545	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BW19, O60887, Q14834, Q9UQP7	Gene names	KIFC1, HSET, KNSL2
Domain Architecture
Description	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET).

KIFC3_HUMAN
θ value	θ > 10 (rank : 903)	NC score	0.053681 (rank : 1293)
Query Neighborhood Hits	479	Target Neighborhood Hits	619	Shared Neighborhood Hits	172
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KIFC3_MOUSE
θ value	θ > 10 (rank : 904)	NC score	0.057999 (rank : 1186)
Query Neighborhood Hits	479	Target Neighborhood Hits	571	Shared Neighborhood Hits	158
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KIT_HUMAN
θ value	θ > 10 (rank : 905)	NC score	0.097255 (rank : 693)
Query Neighborhood Hits	479	Target Neighborhood Hits	953	Shared Neighborhood Hits	58
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 906)	NC score	0.098280 (rank : 674)
Query Neighborhood Hits	479	Target Neighborhood Hits	949	Shared Neighborhood Hits	59
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KNTC2_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.106592 (rank : 556)
Query Neighborhood Hits	479	Target Neighborhood Hits	673	Shared Neighborhood Hits	185
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

KNTC2_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.104855 (rank : 578)
Query Neighborhood Hits	479	Target Neighborhood Hits	692	Shared Neighborhood Hits	187
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

KPCA_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.064035 (rank : 1085)
Query Neighborhood Hits	479	Target Neighborhood Hits	1070	Shared Neighborhood Hits	84
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.063980 (rank : 1088)
Query Neighborhood Hits	479	Target Neighborhood Hits	1067	Shared Neighborhood Hits	84
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.065862 (rank : 1064)
Query Neighborhood Hits	479	Target Neighborhood Hits	1121	Shared Neighborhood Hits	80
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.066151 (rank : 1057)
Query Neighborhood Hits	479	Target Neighborhood Hits	1117	Shared Neighborhood Hits	80
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD1_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.059567 (rank : 1159)
Query Neighborhood Hits	479	Target Neighborhood Hits	901	Shared Neighborhood Hits	75
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_MOUSE
θ value	θ > 10 (rank : 914)	NC score	0.058800 (rank : 1174)
Query Neighborhood Hits	479	Target Neighborhood Hits	891	Shared Neighborhood Hits	75
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD2_HUMAN
θ value	θ > 10 (rank : 915)	NC score	0.060161 (rank : 1147)
Query Neighborhood Hits	479	Target Neighborhood Hits	910	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD3_HUMAN
θ value	θ > 10 (rank : 916)	NC score	0.060433 (rank : 1145)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	75
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
θ value	θ > 10 (rank : 917)	NC score	0.060001 (rank : 1150)
Query Neighborhood Hits	479	Target Neighborhood Hits	901	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCD_HUMAN
θ value	θ > 10 (rank : 918)	NC score	0.065955 (rank : 1063)
Query Neighborhood Hits	479	Target Neighborhood Hits	900	Shared Neighborhood Hits	75
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 919)	NC score	0.065368 (rank : 1072)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	75
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCE_HUMAN
θ value	θ > 10 (rank : 920)	NC score	0.059758 (rank : 1153)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	73
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_MOUSE
θ value	θ > 10 (rank : 921)	NC score	0.060092 (rank : 1149)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	73
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCG_HUMAN
θ value	θ > 10 (rank : 922)	NC score	0.060130 (rank : 1148)
Query Neighborhood Hits	479	Target Neighborhood Hits	1126	Shared Neighborhood Hits	81
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	θ > 10 (rank : 923)	NC score	0.060238 (rank : 1146)
Query Neighborhood Hits	479	Target Neighborhood Hits	1123	Shared Neighborhood Hits	81
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCI_HUMAN
θ value	θ > 10 (rank : 924)	NC score	0.051914 (rank : 1339)
Query Neighborhood Hits	479	Target Neighborhood Hits	885	Shared Neighborhood Hits	75
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	θ > 10 (rank : 925)	NC score	0.051786 (rank : 1348)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	75
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCL_HUMAN
θ value	θ > 10 (rank : 926)	NC score	0.054876 (rank : 1261)
Query Neighborhood Hits	479	Target Neighborhood Hits	887	Shared Neighborhood Hits	73
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_MOUSE
θ value	θ > 10 (rank : 927)	NC score	0.055324 (rank : 1242)
Query Neighborhood Hits	479	Target Neighborhood Hits	891	Shared Neighborhood Hits	73
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_HUMAN
θ value	θ > 10 (rank : 928)	NC score	0.064021 (rank : 1087)
Query Neighborhood Hits	479	Target Neighborhood Hits	897	Shared Neighborhood Hits	74
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 929)	NC score	0.063022 (rank : 1099)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	74
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCZ_HUMAN
θ value	θ > 10 (rank : 930)	NC score	0.050948 (rank : 1390)
Query Neighborhood Hits	479	Target Neighborhood Hits	884	Shared Neighborhood Hits	75
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	θ > 10 (rank : 931)	NC score	0.050361 (rank : 1409)
Query Neighborhood Hits	479	Target Neighborhood Hits	882	Shared Neighborhood Hits	73
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KSR1_HUMAN
θ value	θ > 10 (rank : 932)	NC score	0.082567 (rank : 872)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	68
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 933)	NC score	0.082254 (rank : 875)
Query Neighborhood Hits	479	Target Neighborhood Hits	870	Shared Neighborhood Hits	66
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 934)	NC score	0.084342 (rank : 863)
Query Neighborhood Hits	479	Target Neighborhood Hits	920	Shared Neighborhood Hits	69
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KTN1_HUMAN
θ value	θ > 10 (rank : 935)	NC score	0.125279 (rank : 401)
Query Neighborhood Hits	479	Target Neighborhood Hits	1197	Shared Neighborhood Hits	227
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

KTN1_MOUSE
θ value	θ > 10 (rank : 936)	NC score	0.123902 (rank : 411)
Query Neighborhood Hits	479	Target Neighborhood Hits	1324	Shared Neighborhood Hits	221
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LAMA2_MOUSE
θ value	θ > 10 (rank : 937)	NC score	0.051310 (rank : 1375)
Query Neighborhood Hits	479	Target Neighborhood Hits	1198	Shared Neighborhood Hits	170
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA3_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.053329 (rank : 1302)
Query Neighborhood Hits	479	Target Neighborhood Hits	760	Shared Neighborhood Hits	143
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

LAMB1_HUMAN
θ value	θ > 10 (rank : 939)	NC score	0.051213 (rank : 1379)
Query Neighborhood Hits	479	Target Neighborhood Hits	1018	Shared Neighborhood Hits	180
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LBN_HUMAN
θ value	θ > 10 (rank : 940)	NC score	0.061505 (rank : 1125)
Query Neighborhood Hits	479	Target Neighborhood Hits	308	Shared Neighborhood Hits	113
SwissProt Accessions	Q86UK5, Q86YT3, Q86YT4, Q8NG49	Gene names	EVC2, LBN
Domain Architecture	No domain graphic available
Description	Limbin.

LBN_MOUSE
θ value	θ > 10 (rank : 941)	NC score	0.055094 (rank : 1252)
Query Neighborhood Hits	479	Target Neighborhood Hits	310	Shared Neighborhood Hits	113
SwissProt Accessions	Q8K1G2, Q8BRF3	Gene names	Evc2, Lbn
Domain Architecture	No domain graphic available
Description	Limbin.

LETM1_HUMAN
θ value	θ > 10 (rank : 942)	NC score	0.069679 (rank : 1022)
Query Neighborhood Hits	479	Target Neighborhood Hits	338	Shared Neighborhood Hits	116
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

LETM1_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.059484 (rank : 1161)
Query Neighborhood Hits	479	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

LIMK1_HUMAN
θ value	θ > 10 (rank : 944)	NC score	0.072790 (rank : 982)
Query Neighborhood Hits	479	Target Neighborhood Hits	1005	Shared Neighborhood Hits	62
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 945)	NC score	0.072965 (rank : 979)
Query Neighborhood Hits	479	Target Neighborhood Hits	1008	Shared Neighborhood Hits	63
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 946)	NC score	0.070187 (rank : 1012)
Query Neighborhood Hits	479	Target Neighborhood Hits	986	Shared Neighborhood Hits	64
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 947)	NC score	0.070252 (rank : 1011)
Query Neighborhood Hits	479	Target Neighborhood Hits	998	Shared Neighborhood Hits	64
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIPA1_HUMAN
θ value	θ > 10 (rank : 948)	NC score	0.103863 (rank : 592)
Query Neighborhood Hits	479	Target Neighborhood Hits	1294	Shared Neighborhood Hits	231
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

LIPA2_HUMAN
θ value	θ > 10 (rank : 949)	NC score	0.102133 (rank : 613)
Query Neighborhood Hits	479	Target Neighborhood Hits	1044	Shared Neighborhood Hits	215
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA3_HUMAN
θ value	θ > 10 (rank : 950)	NC score	0.089250 (rank : 802)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	189
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPA3_MOUSE
θ value	θ > 10 (rank : 951)	NC score	0.074582 (rank : 961)
Query Neighborhood Hits	479	Target Neighborhood Hits	636	Shared Neighborhood Hits	163
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPB1_HUMAN
θ value	θ > 10 (rank : 952)	NC score	0.087500 (rank : 825)
Query Neighborhood Hits	479	Target Neighborhood Hits	640	Shared Neighborhood Hits	180
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

LIPB1_MOUSE
θ value	θ > 10 (rank : 953)	NC score	0.078371 (rank : 918)
Query Neighborhood Hits	479	Target Neighborhood Hits	727	Shared Neighborhood Hits	175
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

LIPB2_HUMAN
θ value	θ > 10 (rank : 954)	NC score	0.079092 (rank : 911)
Query Neighborhood Hits	479	Target Neighborhood Hits	599	Shared Neighborhood Hits	168
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

LIPB2_MOUSE
θ value	θ > 10 (rank : 955)	NC score	0.074426 (rank : 963)
Query Neighborhood Hits	479	Target Neighborhood Hits	570	Shared Neighborhood Hits	159
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

LMNA_HUMAN
θ value	θ > 10 (rank : 956)	NC score	0.070296 (rank : 1010)
Query Neighborhood Hits	479	Target Neighborhood Hits	653	Shared Neighborhood Hits	179
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

LMNA_MOUSE
θ value	θ > 10 (rank : 957)	NC score	0.072195 (rank : 990)
Query Neighborhood Hits	479	Target Neighborhood Hits	661	Shared Neighborhood Hits	182
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

LMNB1_HUMAN
θ value	θ > 10 (rank : 958)	NC score	0.073675 (rank : 970)
Query Neighborhood Hits	479	Target Neighborhood Hits	714	Shared Neighborhood Hits	188
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

LMNB1_MOUSE
θ value	θ > 10 (rank : 959)	NC score	0.073111 (rank : 975)
Query Neighborhood Hits	479	Target Neighborhood Hits	719	Shared Neighborhood Hits	186
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

LMNB2_HUMAN
θ value	θ > 10 (rank : 960)	NC score	0.069858 (rank : 1016)
Query Neighborhood Hits	479	Target Neighborhood Hits	723	Shared Neighborhood Hits	184
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

LMNB2_MOUSE
θ value	θ > 10 (rank : 961)	NC score	0.066618 (rank : 1051)
Query Neighborhood Hits	479	Target Neighborhood Hits	674	Shared Neighborhood Hits	182
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

LMO7_HUMAN
θ value	θ > 10 (rank : 962)	NC score	0.059410 (rank : 1163)
Query Neighborhood Hits	479	Target Neighborhood Hits	507	Shared Neighborhood Hits	100
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LNK_HUMAN
θ value	θ > 10 (rank : 963)	NC score	0.217785 (rank : 140)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 964)	NC score	0.214630 (rank : 142)
Query Neighborhood Hits	479	Target Neighborhood Hits	132	Shared Neighborhood Hits	94
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC45_HUMAN
θ value	θ > 10 (rank : 965)	NC score	0.114694 (rank : 474)
Query Neighborhood Hits	479	Target Neighborhood Hits	933	Shared Neighborhood Hits	200
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_MOUSE
θ value	θ > 10 (rank : 966)	NC score	0.106556 (rank : 557)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	202
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRRF1_HUMAN
θ value	θ > 10 (rank : 967)	NC score	0.063628 (rank : 1090)
Query Neighborhood Hits	479	Target Neighborhood Hits	625	Shared Neighborhood Hits	136
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LRRF2_MOUSE
θ value	θ > 10 (rank : 968)	NC score	0.100346 (rank : 639)
Query Neighborhood Hits	479	Target Neighborhood Hits	556	Shared Neighborhood Hits	167
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 969)	NC score	0.061136 (rank : 1131)
Query Neighborhood Hits	479	Target Neighborhood Hits	1237	Shared Neighborhood Hits	58
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 970)	NC score	0.061564 (rank : 1124)
Query Neighborhood Hits	479	Target Neighborhood Hits	1267	Shared Neighborhood Hits	58
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 971)	NC score	0.060583 (rank : 1140)
Query Neighborhood Hits	479	Target Neighborhood Hits	1382	Shared Neighborhood Hits	63
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 972)	NC score	0.059987 (rank : 1151)
Query Neighborhood Hits	479	Target Neighborhood Hits	1359	Shared Neighborhood Hits	64
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRSM1_HUMAN
θ value	θ > 10 (rank : 973)	NC score	0.066560 (rank : 1053)
Query Neighborhood Hits	479	Target Neighborhood Hits	1078	Shared Neighborhood Hits	182
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LRSM1_MOUSE
θ value	θ > 10 (rank : 974)	NC score	0.057511 (rank : 1197)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	153
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

LTK_HUMAN
θ value	θ > 10 (rank : 975)	NC score	0.108291 (rank : 534)
Query Neighborhood Hits	479	Target Neighborhood Hits	774	Shared Neighborhood Hits	58
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 976)	NC score	0.108178 (rank : 536)
Query Neighborhood Hits	479	Target Neighborhood Hits	770	Shared Neighborhood Hits	60
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LUZP1_HUMAN
θ value	θ > 10 (rank : 977)	NC score	0.115285 (rank : 467)
Query Neighborhood Hits	479	Target Neighborhood Hits	739	Shared Neighborhood Hits	192
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

LUZP1_MOUSE
θ value	θ > 10 (rank : 978)	NC score	0.111817 (rank : 497)
Query Neighborhood Hits	479	Target Neighborhood Hits	940	Shared Neighborhood Hits	203
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

LZTS1_HUMAN
θ value	θ > 10 (rank : 979)	NC score	0.085970 (rank : 844)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS1_MOUSE
θ value	θ > 10 (rank : 980)	NC score	0.089104 (rank : 806)
Query Neighborhood Hits	479	Target Neighborhood Hits	540	Shared Neighborhood Hits	154
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS2_HUMAN
θ value	θ > 10 (rank : 981)	NC score	0.078517 (rank : 916)
Query Neighborhood Hits	479	Target Neighborhood Hits	427	Shared Neighborhood Hits	137
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

LZTS2_MOUSE
θ value	θ > 10 (rank : 982)	NC score	0.072457 (rank : 987)
Query Neighborhood Hits	479	Target Neighborhood Hits	423	Shared Neighborhood Hits	132
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

M3K10_HUMAN
θ value	θ > 10 (rank : 983)	NC score	0.105687 (rank : 567)
Query Neighborhood Hits	479	Target Neighborhood Hits	1071	Shared Neighborhood Hits	150
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 984)	NC score	0.109911 (rank : 519)
Query Neighborhood Hits	479	Target Neighborhood Hits	1136	Shared Neighborhood Hits	139
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 985)	NC score	0.078526 (rank : 915)
Query Neighborhood Hits	479	Target Neighborhood Hits	940	Shared Neighborhood Hits	66
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 986)	NC score	0.078495 (rank : 917)
Query Neighborhood Hits	479	Target Neighborhood Hits	957	Shared Neighborhood Hits	67
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 987)	NC score	0.078942 (rank : 913)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	64
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 988)	NC score	0.051510 (rank : 1361)
Query Neighborhood Hits	479	Target Neighborhood Hits	914	Shared Neighborhood Hits	69
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K2_HUMAN
θ value	θ > 10 (rank : 989)	NC score	0.050314 (rank : 1411)
Query Neighborhood Hits	479	Target Neighborhood Hits	849	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 990)	NC score	0.051507 (rank : 1362)
Query Neighborhood Hits	479	Target Neighborhood Hits	885	Shared Neighborhood Hits	61
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 991)	NC score	0.051352 (rank : 1370)
Query Neighborhood Hits	479	Target Neighborhood Hits	876	Shared Neighborhood Hits	61
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K9_HUMAN
θ value	θ > 10 (rank : 992)	NC score	0.109117 (rank : 528)
Query Neighborhood Hits	479	Target Neighborhood Hits	1123	Shared Neighborhood Hits	163
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 993)	NC score	0.114409 (rank : 476)
Query Neighborhood Hits	479	Target Neighborhood Hits	1087	Shared Neighborhood Hits	171
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_MOUSE
θ value	θ > 10 (rank : 994)	NC score	0.050696 (rank : 1396)
Query Neighborhood Hits	479	Target Neighborhood Hits	858	Shared Neighborhood Hits	58
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K4_HUMAN
θ value	θ > 10 (rank : 995)	NC score	0.074916 (rank : 955)
Query Neighborhood Hits	479	Target Neighborhood Hits	1589	Shared Neighborhood Hits	224
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 996)	NC score	0.079258 (rank : 909)
Query Neighborhood Hits	479	Target Neighborhood Hits	1560	Shared Neighborhood Hits	214
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MACF1_MOUSE
θ value	θ > 10 (rank : 997)	NC score	0.096107 (rank : 715)
Query Neighborhood Hits	479	Target Neighborhood Hits	1313	Shared Neighborhood Hits	217
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACOI_HUMAN
θ value	θ > 10 (rank : 998)	NC score	0.096670 (rank : 705)
Query Neighborhood Hits	479	Target Neighborhood Hits	650	Shared Neighborhood Hits	173
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACOI_MOUSE
θ value	θ > 10 (rank : 999)	NC score	0.100573 (rank : 634)
Query Neighborhood Hits	479	Target Neighborhood Hits	620	Shared Neighborhood Hits	173
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MAK_HUMAN
θ value	θ > 10 (rank : 1000)	NC score	0.053561 (rank : 1299)
Query Neighborhood Hits	479	Target Neighborhood Hits	857	Shared Neighborhood Hits	60
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 1001)	NC score	0.054310 (rank : 1280)
Query Neighborhood Hits	479	Target Neighborhood Hits	873	Shared Neighborhood Hits	59
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAP1B_MOUSE
θ value	θ > 10 (rank : 1002)	NC score	0.058272 (rank : 1181)
Query Neighborhood Hits	479	Target Neighborhood Hits	977	Shared Neighborhood Hits	135
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MAP9_MOUSE
θ value	θ > 10 (rank : 1003)	NC score	0.073203 (rank : 974)
Query Neighborhood Hits	479	Target Neighborhood Hits	529	Shared Neighborhood Hits	127
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MARK1_HUMAN
θ value	θ > 10 (rank : 1004)	NC score	0.051323 (rank : 1373)
Query Neighborhood Hits	479	Target Neighborhood Hits	887	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 1005)	NC score	0.051583 (rank : 1357)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 1006)	NC score	0.051663 (rank : 1353)
Query Neighborhood Hits	479	Target Neighborhood Hits	1056	Shared Neighborhood Hits	69
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 1007)	NC score	0.050828 (rank : 1393)
Query Neighborhood Hits	479	Target Neighborhood Hits	1018	Shared Neighborhood Hits	64
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 1008)	NC score	0.051833 (rank : 1346)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 1009)	NC score	0.051721 (rank : 1349)
Query Neighborhood Hits	479	Target Neighborhood Hits	919	Shared Neighborhood Hits	59
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 1010)	NC score	0.052137 (rank : 1335)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	60
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 1011)	NC score	0.052148 (rank : 1334)
Query Neighborhood Hits	479	Target Neighborhood Hits	898	Shared Neighborhood Hits	60
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MASTL_HUMAN
θ value	θ > 10 (rank : 1012)	NC score	0.050494 (rank : 1407)
Query Neighborhood Hits	479	Target Neighborhood Hits	894	Shared Neighborhood Hits	59
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	θ > 10 (rank : 1013)	NC score	0.051717 (rank : 1350)
Query Neighborhood Hits	479	Target Neighborhood Hits	862	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MCF2L_MOUSE
θ value	θ > 10 (rank : 1014)	NC score	0.075807 (rank : 944)
Query Neighborhood Hits	479	Target Neighborhood Hits	255	Shared Neighborhood Hits	78
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 1015)	NC score	0.054662 (rank : 1268)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MD1L1_HUMAN
θ value	θ > 10 (rank : 1016)	NC score	0.117140 (rank : 458)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	210
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MD1L1_MOUSE
θ value	θ > 10 (rank : 1017)	NC score	0.118728 (rank : 446)
Query Neighborhood Hits	479	Target Neighborhood Hits	1001	Shared Neighborhood Hits	215
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MERL_HUMAN
θ value	θ > 10 (rank : 1018)	NC score	0.068962 (rank : 1030)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	157
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 1019)	NC score	0.068804 (rank : 1033)
Query Neighborhood Hits	479	Target Neighborhood Hits	524	Shared Neighborhood Hits	156
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MERTK_HUMAN
θ value	θ > 10 (rank : 1020)	NC score	0.100590 (rank : 633)
Query Neighborhood Hits	479	Target Neighborhood Hits	988	Shared Neighborhood Hits	58
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 1021)	NC score	0.100095 (rank : 647)
Query Neighborhood Hits	479	Target Neighborhood Hits	974	Shared Neighborhood Hits	58
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 1022)	NC score	0.097406 (rank : 691)
Query Neighborhood Hits	479	Target Neighborhood Hits	831	Shared Neighborhood Hits	58
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 1023)	NC score	0.098009 (rank : 679)
Query Neighborhood Hits	479	Target Neighborhood Hits	844	Shared Neighborhood Hits	58
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MFAP1_HUMAN
θ value	θ > 10 (rank : 1024)	NC score	0.067145 (rank : 1042)
Query Neighborhood Hits	479	Target Neighborhood Hits	321	Shared Neighborhood Hits	96
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

MFAP1_MOUSE
θ value	θ > 10 (rank : 1025)	NC score	0.085307 (rank : 849)
Query Neighborhood Hits	479	Target Neighborhood Hits	353	Shared Neighborhood Hits	111
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

MINK1_HUMAN
θ value	θ > 10 (rank : 1026)	NC score	0.066136 (rank : 1058)
Query Neighborhood Hits	479	Target Neighborhood Hits	1477	Shared Neighborhood Hits	190
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 1027)	NC score	0.066001 (rank : 1062)
Query Neighborhood Hits	479	Target Neighborhood Hits	1451	Shared Neighborhood Hits	188
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MIPO1_HUMAN
θ value	θ > 10 (rank : 1028)	NC score	0.100568 (rank : 635)
Query Neighborhood Hits	479	Target Neighborhood Hits	486	Shared Neighborhood Hits	156
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

MLKL_HUMAN
θ value	θ > 10 (rank : 1029)	NC score	0.091778 (rank : 768)
Query Neighborhood Hits	479	Target Neighborhood Hits	600	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 1030)	NC score	0.088392 (rank : 814)
Query Neighborhood Hits	479	Target Neighborhood Hits	707	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 1031)	NC score	0.084489 (rank : 860)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 1032)	NC score	0.084554 (rank : 859)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MMRN1_HUMAN
θ value	θ > 10 (rank : 1033)	NC score	0.079600 (rank : 904)
Query Neighborhood Hits	479	Target Neighborhood Hits	636	Shared Neighborhood Hits	134
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

MMRN2_HUMAN
θ value	θ > 10 (rank : 1034)	NC score	0.061742 (rank : 1120)
Query Neighborhood Hits	479	Target Neighborhood Hits	400	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H8L6, Q6P2N2	Gene names	MMRN2, EMILIN3
Domain Architecture
Description	Multimerin-2 precursor (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit).

MORC3_HUMAN
θ value	θ > 10 (rank : 1035)	NC score	0.071927 (rank : 993)
Query Neighborhood Hits	479	Target Neighborhood Hits	489	Shared Neighborhood Hits	146
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

MOS_HUMAN
θ value	θ > 10 (rank : 1036)	NC score	0.080498 (rank : 892)
Query Neighborhood Hits	479	Target Neighborhood Hits	829	Shared Neighborhood Hits	58
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 1037)	NC score	0.080408 (rank : 893)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	58
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 1038)	NC score	0.055013 (rank : 1255)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 1039)	NC score	0.055141 (rank : 1249)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 1040)	NC score	0.056807 (rank : 1209)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	59
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 1041)	NC score	0.056939 (rank : 1205)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	58
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 1042)	NC score	0.053657 (rank : 1294)
Query Neighborhood Hits	479	Target Neighborhood Hits	825	Shared Neighborhood Hits	58
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 1043)	NC score	0.054189 (rank : 1284)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 1044)	NC score	0.054608 (rank : 1269)
Query Neighborhood Hits	479	Target Neighborhood Hits	832	Shared Neighborhood Hits	58
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 1045)	NC score	0.054504 (rank : 1272)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	58
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 1046)	NC score	0.054059 (rank : 1286)
Query Neighborhood Hits	479	Target Neighborhood Hits	837	Shared Neighborhood Hits	60
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 1047)	NC score	0.055972 (rank : 1232)
Query Neighborhood Hits	479	Target Neighborhood Hits	840	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 1048)	NC score	0.053968 (rank : 1290)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	58
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 1049)	NC score	0.054046 (rank : 1289)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	58
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 1050)	NC score	0.056362 (rank : 1221)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	58
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MPP9_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.092407 (rank : 760)
Query Neighborhood Hits	479	Target Neighborhood Hits	529	Shared Neighborhood Hits	153
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

MRCKG_HUMAN
θ value	θ > 10 (rank : 1052)	NC score	0.076389 (rank : 939)
Query Neighborhood Hits	479	Target Neighborhood Hits	1519	Shared Neighborhood Hits	225
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
θ value	θ > 10 (rank : 1053)	NC score	0.072568 (rank : 986)
Query Neighborhood Hits	479	Target Neighborhood Hits	1466	Shared Neighborhood Hits	217
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRIP_HUMAN
θ value	θ > 10 (rank : 1054)	NC score	0.097940 (rank : 681)
Query Neighborhood Hits	479	Target Neighborhood Hits	578	Shared Neighborhood Hits	160
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

MRIP_MOUSE
θ value	θ > 10 (rank : 1055)	NC score	0.096387 (rank : 711)
Query Neighborhood Hits	479	Target Neighborhood Hits	569	Shared Neighborhood Hits	166
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MST4_HUMAN
θ value	θ > 10 (rank : 1056)	NC score	0.059128 (rank : 1166)
Query Neighborhood Hits	479	Target Neighborhood Hits	852	Shared Neighborhood Hits	58
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 1057)	NC score	0.059009 (rank : 1169)
Query Neighborhood Hits	479	Target Neighborhood Hits	860	Shared Neighborhood Hits	58
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUSK_HUMAN
θ value	θ > 10 (rank : 1058)	NC score	0.091503 (rank : 771)
Query Neighborhood Hits	479	Target Neighborhood Hits	1074	Shared Neighborhood Hits	58
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 1059)	NC score	0.091740 (rank : 769)
Query Neighborhood Hits	479	Target Neighborhood Hits	1057	Shared Neighborhood Hits	58
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MY18B_HUMAN
θ value	θ > 10 (rank : 1060)	NC score	0.109989 (rank : 516)
Query Neighborhood Hits	479	Target Neighborhood Hits	1299	Shared Neighborhood Hits	209
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYH10_MOUSE
θ value	θ > 10 (rank : 1061)	NC score	0.126677 (rank : 390)
Query Neighborhood Hits	479	Target Neighborhood Hits	1612	Shared Neighborhood Hits	246
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH14_HUMAN
θ value	θ > 10 (rank : 1062)	NC score	0.109396 (rank : 527)
Query Neighborhood Hits	479	Target Neighborhood Hits	995	Shared Neighborhood Hits	211
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH14_MOUSE
θ value	θ > 10 (rank : 1063)	NC score	0.115210 (rank : 469)
Query Neighborhood Hits	479	Target Neighborhood Hits	1225	Shared Neighborhood Hits	230
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH1_MOUSE
θ value	θ > 10 (rank : 1064)	NC score	0.129641 (rank : 367)
Query Neighborhood Hits	479	Target Neighborhood Hits	1461	Shared Neighborhood Hits	248
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH4_HUMAN
θ value	θ > 10 (rank : 1065)	NC score	0.127075 (rank : 387)
Query Neighborhood Hits	479	Target Neighborhood Hits	1377	Shared Neighborhood Hits	246
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH6_HUMAN
θ value	θ > 10 (rank : 1066)	NC score	0.120185 (rank : 435)
Query Neighborhood Hits	479	Target Neighborhood Hits	1426	Shared Neighborhood Hits	244
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_MOUSE
θ value	θ > 10 (rank : 1067)	NC score	0.119114 (rank : 444)
Query Neighborhood Hits	479	Target Neighborhood Hits	1501	Shared Neighborhood Hits	244
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH8_MOUSE
θ value	θ > 10 (rank : 1068)	NC score	0.127308 (rank : 385)
Query Neighborhood Hits	479	Target Neighborhood Hits	1600	Shared Neighborhood Hits	254
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYLK2_HUMAN
θ value	θ > 10 (rank : 1069)	NC score	0.057342 (rank : 1199)
Query Neighborhood Hits	479	Target Neighborhood Hits	920	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYO10_HUMAN
θ value	θ > 10 (rank : 1070)	NC score	0.107548 (rank : 540)
Query Neighborhood Hits	479	Target Neighborhood Hits	920	Shared Neighborhood Hits	202
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO15_HUMAN
θ value	θ > 10 (rank : 1071)	NC score	0.052274 (rank : 1331)
Query Neighborhood Hits	479	Target Neighborhood Hits	671	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO15_MOUSE
θ value	θ > 10 (rank : 1072)	NC score	0.053608 (rank : 1297)
Query Neighborhood Hits	479	Target Neighborhood Hits	467	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO1A_HUMAN
θ value	θ > 10 (rank : 1073)	NC score	0.050510 (rank : 1406)
Query Neighborhood Hits	479	Target Neighborhood Hits	67	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

MYO1B_HUMAN
θ value	θ > 10 (rank : 1074)	NC score	0.050265 (rank : 1416)
Query Neighborhood Hits	479	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	O43795, O43794, Q7Z6L5	Gene names	MYO1B
Domain Architecture	No domain graphic available
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

MYO1B_MOUSE
θ value	θ > 10 (rank : 1075)	NC score	0.050283 (rank : 1413)
Query Neighborhood Hits	479	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

MYO1C_HUMAN
θ value	θ > 10 (rank : 1076)	NC score	0.050226 (rank : 1420)
Query Neighborhood Hits	479	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

MYO1C_MOUSE
θ value	θ > 10 (rank : 1077)	NC score	0.050256 (rank : 1418)
Query Neighborhood Hits	479	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

MYO1D_HUMAN
θ value	θ > 10 (rank : 1078)	NC score	0.050242 (rank : 1419)
Query Neighborhood Hits	479	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	O94832, Q8NHP9	Gene names	MYO1D, KIAA0727
Domain Architecture
Description	Myosin Id.

MYO1D_MOUSE
θ value	θ > 10 (rank : 1079)	NC score	0.050187 (rank : 1422)
Query Neighborhood Hits	479	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SYD0, Q5SSK7, Q8BWY5	Gene names	Myo1d
Domain Architecture	No domain graphic available
Description	Myosin Id.

MYO1E_HUMAN
θ value	θ > 10 (rank : 1080)	NC score	0.112099 (rank : 494)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	119
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 1081)	NC score	0.116306 (rank : 464)
Query Neighborhood Hits	479	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 1082)	NC score	0.117134 (rank : 459)
Query Neighborhood Hits	479	Target Neighborhood Hits	262	Shared Neighborhood Hits	123
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO3A_HUMAN
θ value	θ > 10 (rank : 1083)	NC score	0.075297 (rank : 949)
Query Neighborhood Hits	479	Target Neighborhood Hits	1033	Shared Neighborhood Hits	107
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 1084)	NC score	0.071253 (rank : 996)
Query Neighborhood Hits	479	Target Neighborhood Hits	902	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
θ value	θ > 10 (rank : 1085)	NC score	0.066257 (rank : 1056)
Query Neighborhood Hits	479	Target Neighborhood Hits	923	Shared Neighborhood Hits	76
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

MYO5A_HUMAN
θ value	θ > 10 (rank : 1086)	NC score	0.106964 (rank : 549)
Query Neighborhood Hits	479	Target Neighborhood Hits	1092	Shared Neighborhood Hits	208
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5A_MOUSE
θ value	θ > 10 (rank : 1087)	NC score	0.103914 (rank : 591)
Query Neighborhood Hits	479	Target Neighborhood Hits	1117	Shared Neighborhood Hits	217
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5B_HUMAN
θ value	θ > 10 (rank : 1088)	NC score	0.099910 (rank : 650)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	206
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO5C_HUMAN
θ value	θ > 10 (rank : 1089)	NC score	0.112716 (rank : 489)
Query Neighborhood Hits	479	Target Neighborhood Hits	1206	Shared Neighborhood Hits	228
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 1090)	NC score	0.093041 (rank : 755)
Query Neighborhood Hits	479	Target Neighborhood Hits	727	Shared Neighborhood Hits	182
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO6_MOUSE
θ value	θ > 10 (rank : 1091)	NC score	0.084937 (rank : 854)
Query Neighborhood Hits	479	Target Neighborhood Hits	586	Shared Neighborhood Hits	164
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

NCF1_HUMAN
θ value	θ > 10 (rank : 1092)	NC score	0.142895 (rank : 301)
Query Neighborhood Hits	479	Target Neighborhood Hits	198	Shared Neighborhood Hits	87
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 1093)	NC score	0.144548 (rank : 292)
Query Neighborhood Hits	479	Target Neighborhood Hits	198	Shared Neighborhood Hits	92
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 1094)	NC score	0.106548 (rank : 559)
Query Neighborhood Hits	479	Target Neighborhood Hits	161	Shared Neighborhood Hits	74
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 1095)	NC score	0.125509 (rank : 396)
Query Neighborhood Hits	479	Target Neighborhood Hits	177	Shared Neighborhood Hits	84
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 1096)	NC score	0.381220 (rank : 62)
Query Neighborhood Hits	479	Target Neighborhood Hits	312	Shared Neighborhood Hits	175
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NDE1_HUMAN
θ value	θ > 10 (rank : 1097)	NC score	0.096025 (rank : 717)
Query Neighborhood Hits	479	Target Neighborhood Hits	823	Shared Neighborhood Hits	200
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

NDE1_MOUSE
θ value	θ > 10 (rank : 1098)	NC score	0.086708 (rank : 835)
Query Neighborhood Hits	479	Target Neighborhood Hits	602	Shared Neighborhood Hits	177
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

NDEL1_HUMAN
θ value	θ > 10 (rank : 1099)	NC score	0.077484 (rank : 928)
Query Neighborhood Hits	479	Target Neighborhood Hits	415	Shared Neighborhood Hits	140
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

NDEL1_MOUSE
θ value	θ > 10 (rank : 1100)	NC score	0.076948 (rank : 936)
Query Neighborhood Hits	479	Target Neighborhood Hits	420	Shared Neighborhood Hits	140
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

NEB1_HUMAN
θ value	θ > 10 (rank : 1101)	NC score	0.056318 (rank : 1225)
Query Neighborhood Hits	479	Target Neighborhood Hits	829	Shared Neighborhood Hits	149
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NEB2_HUMAN
θ value	θ > 10 (rank : 1102)	NC score	0.063352 (rank : 1095)
Query Neighborhood Hits	479	Target Neighborhood Hits	883	Shared Neighborhood Hits	167
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 1103)	NC score	0.065442 (rank : 1069)
Query Neighborhood Hits	479	Target Neighborhood Hits	889	Shared Neighborhood Hits	169
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEK11_HUMAN
θ value	θ > 10 (rank : 1104)	NC score	0.065513 (rank : 1067)
Query Neighborhood Hits	479	Target Neighborhood Hits	1043	Shared Neighborhood Hits	118
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 1105)	NC score	0.062432 (rank : 1106)
Query Neighborhood Hits	479	Target Neighborhood Hits	875	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 1106)	NC score	0.056317 (rank : 1226)
Query Neighborhood Hits	479	Target Neighborhood Hits	1129	Shared Neighborhood Hits	123
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 1107)	NC score	0.057950 (rank : 1190)
Query Neighborhood Hits	479	Target Neighborhood Hits	1311	Shared Neighborhood Hits	143
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 1108)	NC score	0.055610 (rank : 1236)
Query Neighborhood Hits	479	Target Neighborhood Hits	908	Shared Neighborhood Hits	91
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 1109)	NC score	0.053339 (rank : 1301)
Query Neighborhood Hits	479	Target Neighborhood Hits	876	Shared Neighborhood Hits	73
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 1110)	NC score	0.055025 (rank : 1254)
Query Neighborhood Hits	479	Target Neighborhood Hits	865	Shared Neighborhood Hits	62
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 1111)	NC score	0.053927 (rank : 1291)
Query Neighborhood Hits	479	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 1112)	NC score	0.054938 (rank : 1258)
Query Neighborhood Hits	479	Target Neighborhood Hits	883	Shared Neighborhood Hits	61
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 1113)	NC score	0.055334 (rank : 1241)
Query Neighborhood Hits	479	Target Neighborhood Hits	899	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 1114)	NC score	0.056688 (rank : 1211)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 1115)	NC score	0.056936 (rank : 1206)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 1116)	NC score	0.056351 (rank : 1223)
Query Neighborhood Hits	479	Target Neighborhood Hits	846	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 1117)	NC score	0.056309 (rank : 1227)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 1118)	NC score	0.050570 (rank : 1402)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 1119)	NC score	0.050302 (rank : 1412)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEMO_HUMAN
θ value	θ > 10 (rank : 1120)	NC score	0.099632 (rank : 654)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NEMO_MOUSE
θ value	θ > 10 (rank : 1121)	NC score	0.103493 (rank : 596)
Query Neighborhood Hits	479	Target Neighborhood Hits	658	Shared Neighborhood Hits	178
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NEST_HUMAN
θ value	θ > 10 (rank : 1122)	NC score	0.078699 (rank : 914)
Query Neighborhood Hits	479	Target Neighborhood Hits	1305	Shared Neighborhood Hits	181
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NFM_HUMAN
θ value	θ > 10 (rank : 1123)	NC score	0.070853 (rank : 1003)
Query Neighborhood Hits	479	Target Neighborhood Hits	1328	Shared Neighborhood Hits	209
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NGAP_HUMAN
θ value	θ > 10 (rank : 1124)	NC score	0.056353 (rank : 1222)
Query Neighborhood Hits	479	Target Neighborhood Hits	517	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

NGEF_HUMAN
θ value	θ > 10 (rank : 1125)	NC score	0.080082 (rank : 899)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 1126)	NC score	0.083014 (rank : 867)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NIM1_HUMAN
θ value	θ > 10 (rank : 1127)	NC score	0.051515 (rank : 1359)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 1128)	NC score	0.051289 (rank : 1376)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIN_MOUSE
θ value	θ > 10 (rank : 1129)	NC score	0.118321 (rank : 451)
Query Neighborhood Hits	479	Target Neighborhood Hits	1376	Shared Neighborhood Hits	233
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

NOP14_HUMAN
θ value	θ > 10 (rank : 1130)	NC score	0.054245 (rank : 1281)
Query Neighborhood Hits	479	Target Neighborhood Hits	573	Shared Neighborhood Hits	121
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

NOXO1_HUMAN
θ value	θ > 10 (rank : 1131)	NC score	0.058933 (rank : 1170)
Query Neighborhood Hits	479	Target Neighborhood Hits	100	Shared Neighborhood Hits	42
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 1132)	NC score	0.079550 (rank : 905)
Query Neighborhood Hits	479	Target Neighborhood Hits	114	Shared Neighborhood Hits	57
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 1133)	NC score	0.177098 (rank : 213)
Query Neighborhood Hits	479	Target Neighborhood Hits	288	Shared Neighborhood Hits	126
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1134)	NC score	0.192842 (rank : 180)
Query Neighborhood Hits	479	Target Neighborhood Hits	267	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NTBP1_MOUSE
θ value	θ > 10 (rank : 1135)	NC score	0.057712 (rank : 1194)
Query Neighborhood Hits	479	Target Neighborhood Hits	528	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

NTRK1_HUMAN
θ value	θ > 10 (rank : 1136)	NC score	0.100689 (rank : 629)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	58
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 1137)	NC score	0.093911 (rank : 746)
Query Neighborhood Hits	479	Target Neighborhood Hits	1081	Shared Neighborhood Hits	58
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 1138)	NC score	0.093906 (rank : 747)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	58
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 1139)	NC score	0.097692 (rank : 686)
Query Neighborhood Hits	479	Target Neighborhood Hits	1115	Shared Neighborhood Hits	58
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NUAK1_HUMAN
θ value	θ > 10 (rank : 1140)	NC score	0.052245 (rank : 1333)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 1141)	NC score	0.052899 (rank : 1318)
Query Neighborhood Hits	479	Target Neighborhood Hits	881	Shared Neighborhood Hits	64
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 1142)	NC score	0.051054 (rank : 1385)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUCB1_MOUSE
θ value	θ > 10 (rank : 1143)	NC score	0.050558 (rank : 1403)
Query Neighborhood Hits	479	Target Neighborhood Hits	414	Shared Neighborhood Hits	116
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

NUCB2_HUMAN
θ value	θ > 10 (rank : 1144)	NC score	0.062364 (rank : 1108)
Query Neighborhood Hits	479	Target Neighborhood Hits	321	Shared Neighborhood Hits	121
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

NUCB2_MOUSE
θ value	θ > 10 (rank : 1145)	NC score	0.068041 (rank : 1037)
Query Neighborhood Hits	479	Target Neighborhood Hits	459	Shared Neighborhood Hits	134
SwissProt Accessions	P81117	Gene names	Nucb2, Nefa
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA).

NUF2_MOUSE
θ value	θ > 10 (rank : 1146)	NC score	0.108361 (rank : 533)
Query Neighborhood Hits	479	Target Neighborhood Hits	585	Shared Neighborhood Hits	168
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

NUMA1_HUMAN
θ value	θ > 10 (rank : 1147)	NC score	0.135474 (rank : 318)
Query Neighborhood Hits	479	Target Neighborhood Hits	1523	Shared Neighborhood Hits	246
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

NUP88_HUMAN
θ value	θ > 10 (rank : 1148)	NC score	0.055775 (rank : 1235)
Query Neighborhood Hits	479	Target Neighborhood Hits	354	Shared Neighborhood Hits	118
SwissProt Accessions	Q99567, Q9BWE5	Gene names	NUP88
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup88 (Nucleoporin Nup88) (88 kDa nuclear pore complex protein).

OFD1_HUMAN
θ value	θ > 10 (rank : 1149)	NC score	0.134724 (rank : 325)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	188
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

OLR1_MOUSE
θ value	θ > 10 (rank : 1150)	NC score	0.070638 (rank : 1006)
Query Neighborhood Hits	479	Target Neighborhood Hits	596	Shared Neighborhood Hits	149
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

OPTN_HUMAN
θ value	θ > 10 (rank : 1151)	NC score	0.105896 (rank : 565)
Query Neighborhood Hits	479	Target Neighborhood Hits	827	Shared Neighborhood Hits	185
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

OSTF1_HUMAN
θ value	θ > 10 (rank : 1152)	NC score	0.145771 (rank : 285)
Query Neighborhood Hits	479	Target Neighborhood Hits	466	Shared Neighborhood Hits	111
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 1153)	NC score	0.138209 (rank : 309)
Query Neighborhood Hits	479	Target Neighborhood Hits	467	Shared Neighborhood Hits	112
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OXSR1_HUMAN
θ value	θ > 10 (rank : 1154)	NC score	0.061412 (rank : 1127)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	58
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 1155)	NC score	0.061583 (rank : 1122)
Query Neighborhood Hits	479	Target Neighborhood Hits	865	Shared Neighborhood Hits	60
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAWR_HUMAN
θ value	θ > 10 (rank : 1156)	NC score	0.054700 (rank : 1265)
Query Neighborhood Hits	479	Target Neighborhood Hits	252	Shared Neighborhood Hits	79
SwissProt Accessions	Q96IZ0, O75796, Q6FHY9, Q8N700	Gene names	PAWR, PAR4
Domain Architecture	No domain graphic available
Description	PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4).

PCNT_HUMAN
θ value	θ > 10 (rank : 1157)	NC score	0.123589 (rank : 412)
Query Neighborhood Hits	479	Target Neighborhood Hits	1551	Shared Neighborhood Hits	245
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PCNT_MOUSE
θ value	θ > 10 (rank : 1158)	NC score	0.113118 (rank : 486)
Query Neighborhood Hits	479	Target Neighborhood Hits	1207	Shared Neighborhood Hits	216
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PEPL_HUMAN
θ value	θ > 10 (rank : 1159)	NC score	0.125282 (rank : 400)
Query Neighborhood Hits	479	Target Neighborhood Hits	1141	Shared Neighborhood Hits	223
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PEPL_MOUSE
θ value	θ > 10 (rank : 1160)	NC score	0.118663 (rank : 448)
Query Neighborhood Hits	479	Target Neighborhood Hits	1105	Shared Neighborhood Hits	227
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PGFRA_HUMAN
θ value	θ > 10 (rank : 1161)	NC score	0.097458 (rank : 689)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	60
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 1162)	NC score	0.097539 (rank : 687)
Query Neighborhood Hits	479	Target Neighborhood Hits	975	Shared Neighborhood Hits	58
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 1163)	NC score	0.098046 (rank : 678)
Query Neighborhood Hits	479	Target Neighborhood Hits	962	Shared Neighborhood Hits	58
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 1164)	NC score	0.098149 (rank : 676)
Query Neighborhood Hits	479	Target Neighborhood Hits	960	Shared Neighborhood Hits	59
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PHLB1_HUMAN
θ value	θ > 10 (rank : 1165)	NC score	0.088299 (rank : 816)
Query Neighborhood Hits	479	Target Neighborhood Hits	1038	Shared Neighborhood Hits	188
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB1_MOUSE
θ value	θ > 10 (rank : 1166)	NC score	0.074442 (rank : 962)
Query Neighborhood Hits	479	Target Neighborhood Hits	678	Shared Neighborhood Hits	140
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB2_HUMAN
θ value	θ > 10 (rank : 1167)	NC score	0.112280 (rank : 493)
Query Neighborhood Hits	479	Target Neighborhood Hits	964	Shared Neighborhood Hits	204
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB3_HUMAN
θ value	θ > 10 (rank : 1168)	NC score	0.068020 (rank : 1038)
Query Neighborhood Hits	479	Target Neighborhood Hits	304	Shared Neighborhood Hits	100
SwissProt Accessions	Q6NSJ2, Q8N7Z4	Gene names	PHLDB3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 3.

PININ_HUMAN
θ value	θ > 10 (rank : 1169)	NC score	0.087262 (rank : 827)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PININ_MOUSE
θ value	θ > 10 (rank : 1170)	NC score	0.080184 (rank : 897)
Query Neighborhood Hits	479	Target Neighborhood Hits	777	Shared Neighborhood Hits	153
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PKHA1_HUMAN
θ value	θ > 10 (rank : 1171)	NC score	0.051254 (rank : 1377)
Query Neighborhood Hits	479	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHG1_HUMAN
θ value	θ > 10 (rank : 1172)	NC score	0.066810 (rank : 1045)
Query Neighborhood Hits	479	Target Neighborhood Hits	174	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKN1_MOUSE
θ value	θ > 10 (rank : 1173)	NC score	0.050642 (rank : 1398)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	73
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 1174)	NC score	0.051878 (rank : 1342)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	86
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 1175)	NC score	0.051669 (rank : 1352)
Query Neighborhood Hits	479	Target Neighborhood Hits	899	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PLCB2_HUMAN
θ value	θ > 10 (rank : 1176)	NC score	0.091574 (rank : 770)
Query Neighborhood Hits	479	Target Neighborhood Hits	608	Shared Neighborhood Hits	163
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB3_HUMAN
θ value	θ > 10 (rank : 1177)	NC score	0.065393 (rank : 1071)
Query Neighborhood Hits	479	Target Neighborhood Hits	445	Shared Neighborhood Hits	112
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB3_MOUSE
θ value	θ > 10 (rank : 1178)	NC score	0.072116 (rank : 992)
Query Neighborhood Hits	479	Target Neighborhood Hits	344	Shared Neighborhood Hits	118
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PLCB4_HUMAN
θ value	θ > 10 (rank : 1179)	NC score	0.100694 (rank : 628)
Query Neighborhood Hits	479	Target Neighborhood Hits	658	Shared Neighborhood Hits	172
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLEC1_HUMAN
θ value	θ > 10 (rank : 1180)	NC score	0.111950 (rank : 495)
Query Neighborhood Hits	479	Target Neighborhood Hits	1326	Shared Neighborhood Hits	230
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

PLVAP_HUMAN
θ value	θ > 10 (rank : 1181)	NC score	0.069969 (rank : 1014)
Query Neighborhood Hits	479	Target Neighborhood Hits	397	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

PLVAP_MOUSE
θ value	θ > 10 (rank : 1182)	NC score	0.051608 (rank : 1356)
Query Neighborhood Hits	479	Target Neighborhood Hits	210	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

PPIP2_HUMAN
θ value	θ > 10 (rank : 1183)	NC score	0.082598 (rank : 871)
Query Neighborhood Hits	479	Target Neighborhood Hits	254	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 1184)	NC score	0.086913 (rank : 830)
Query Neighborhood Hits	479	Target Neighborhood Hits	308	Shared Neighborhood Hits	110
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PRC1_HUMAN
θ value	θ > 10 (rank : 1185)	NC score	0.058585 (rank : 1177)
Query Neighborhood Hits	479	Target Neighborhood Hits	328	Shared Neighborhood Hits	115
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

PRC1_MOUSE
θ value	θ > 10 (rank : 1186)	NC score	0.065496 (rank : 1068)
Query Neighborhood Hits	479	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

PREX1_HUMAN
θ value	θ > 10 (rank : 1187)	NC score	0.064034 (rank : 1086)
Query Neighborhood Hits	479	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP4B_HUMAN
θ value	θ > 10 (rank : 1188)	NC score	0.051327 (rank : 1372)
Query Neighborhood Hits	479	Target Neighborhood Hits	1030	Shared Neighborhood Hits	97
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 1189)	NC score	0.051118 (rank : 1383)
Query Neighborhood Hits	479	Target Neighborhood Hits	1040	Shared Neighborhood Hits	96
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 1190)	NC score	0.088234 (rank : 819)
Query Neighborhood Hits	479	Target Neighborhood Hits	1103	Shared Neighborhood Hits	59
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

RABE1_HUMAN
θ value	θ > 10 (rank : 1191)	NC score	0.125288 (rank : 399)
Query Neighborhood Hits	479	Target Neighborhood Hits	1104	Shared Neighborhood Hits	224
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	θ > 10 (rank : 1192)	NC score	0.121899 (rank : 424)
Query Neighborhood Hits	479	Target Neighborhood Hits	1105	Shared Neighborhood Hits	226
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RABE2_HUMAN
θ value	θ > 10 (rank : 1193)	NC score	0.079906 (rank : 900)
Query Neighborhood Hits	479	Target Neighborhood Hits	545	Shared Neighborhood Hits	153
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RABE2_MOUSE
θ value	θ > 10 (rank : 1194)	NC score	0.105341 (rank : 571)
Query Neighborhood Hits	479	Target Neighborhood Hits	598	Shared Neighborhood Hits	173
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RAD50_HUMAN
θ value	θ > 10 (rank : 1195)	NC score	0.131487 (rank : 352)
Query Neighborhood Hits	479	Target Neighborhood Hits	1317	Shared Neighborhood Hits	241
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAF1_HUMAN
θ value	θ > 10 (rank : 1196)	NC score	0.089200 (rank : 804)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	69
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 1197)	NC score	0.088651 (rank : 811)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	69
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAI14_HUMAN
θ value	θ > 10 (rank : 1198)	NC score	0.079379 (rank : 907)
Query Neighborhood Hits	479	Target Neighborhood Hits	1367	Shared Neighborhood Hits	211
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RAI14_MOUSE
θ value	θ > 10 (rank : 1199)	NC score	0.079496 (rank : 906)
Query Neighborhood Hits	479	Target Neighborhood Hits	1505	Shared Neighborhood Hits	217
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RASF8_HUMAN
θ value	θ > 10 (rank : 1200)	NC score	0.118557 (rank : 450)
Query Neighborhood Hits	479	Target Neighborhood Hits	469	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

RASF8_MOUSE
θ value	θ > 10 (rank : 1201)	NC score	0.102780 (rank : 603)
Query Neighborhood Hits	479	Target Neighborhood Hits	391	Shared Neighborhood Hits	140
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

RBBP8_HUMAN
θ value	θ > 10 (rank : 1202)	NC score	0.084613 (rank : 857)
Query Neighborhood Hits	479	Target Neighborhood Hits	476	Shared Neighborhood Hits	134
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

RBCC1_HUMAN
θ value	θ > 10 (rank : 1203)	NC score	0.127616 (rank : 381)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	214
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

RBM25_HUMAN
θ value	θ > 10 (rank : 1204)	NC score	0.093150 (rank : 754)
Query Neighborhood Hits	479	Target Neighborhood Hits	682	Shared Neighborhood Hits	150
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

RENT2_HUMAN
θ value	θ > 10 (rank : 1205)	NC score	0.069679 (rank : 1023)
Query Neighborhood Hits	479	Target Neighborhood Hits	618	Shared Neighborhood Hits	139
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RET_HUMAN
θ value	θ > 10 (rank : 1206)	NC score	0.097703 (rank : 685)
Query Neighborhood Hits	479	Target Neighborhood Hits	873	Shared Neighborhood Hits	58
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 1207)	NC score	0.096988 (rank : 698)
Query Neighborhood Hits	479	Target Neighborhood Hits	884	Shared Neighborhood Hits	58
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RFIP4_HUMAN
θ value	θ > 10 (rank : 1208)	NC score	0.103222 (rank : 598)
Query Neighborhood Hits	479	Target Neighborhood Hits	785	Shared Neighborhood Hits	191
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RFIP4_MOUSE
θ value	θ > 10 (rank : 1209)	NC score	0.096747 (rank : 700)
Query Neighborhood Hits	479	Target Neighborhood Hits	708	Shared Neighborhood Hits	185
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RGNEF_MOUSE
θ value	θ > 10 (rank : 1210)	NC score	0.077241 (rank : 932)
Query Neighborhood Hits	479	Target Neighborhood Hits	641	Shared Neighborhood Hits	136
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG18_MOUSE
θ value	θ > 10 (rank : 1211)	NC score	0.313309 (rank : 97)
Query Neighborhood Hits	479	Target Neighborhood Hits	110	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RILP_MOUSE
θ value	θ > 10 (rank : 1212)	NC score	0.054817 (rank : 1262)
Query Neighborhood Hits	479	Target Neighborhood Hits	257	Shared Neighborhood Hits	87
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RIMB1_HUMAN
θ value	θ > 10 (rank : 1213)	NC score	0.129097 (rank : 375)
Query Neighborhood Hits	479	Target Neighborhood Hits	1479	Shared Neighborhood Hits	264
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 1214)	NC score	0.131456 (rank : 353)
Query Neighborhood Hits	479	Target Neighborhood Hits	1376	Shared Neighborhood Hits	271
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 1215)	NC score	0.075010 (rank : 953)
Query Neighborhood Hits	479	Target Neighborhood Hits	263	Shared Neighborhood Hits	69
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 1216)	NC score	0.081543 (rank : 883)
Query Neighborhood Hits	479	Target Neighborhood Hits	246	Shared Neighborhood Hits	82
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIPK1_HUMAN
θ value	θ > 10 (rank : 1217)	NC score	0.081668 (rank : 882)
Query Neighborhood Hits	479	Target Neighborhood Hits	891	Shared Neighborhood Hits	59
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 1218)	NC score	0.082971 (rank : 868)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 1219)	NC score	0.079625 (rank : 903)
Query Neighborhood Hits	479	Target Neighborhood Hits	774	Shared Neighborhood Hits	58
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 1220)	NC score	0.081046 (rank : 886)
Query Neighborhood Hits	479	Target Neighborhood Hits	776	Shared Neighborhood Hits	58
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 1221)	NC score	0.077862 (rank : 922)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 1222)	NC score	0.078145 (rank : 920)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 1223)	NC score	0.063038 (rank : 1098)
Query Neighborhood Hits	479	Target Neighborhood Hits	1094	Shared Neighborhood Hits	65
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 1224)	NC score	0.072249 (rank : 989)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	64
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 1225)	NC score	0.073008 (rank : 977)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	70
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RNF8_HUMAN
θ value	θ > 10 (rank : 1226)	NC score	0.054335 (rank : 1279)
Query Neighborhood Hits	479	Target Neighborhood Hits	622	Shared Neighborhood Hits	137
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

ROCK1_HUMAN
θ value	θ > 10 (rank : 1227)	NC score	0.103430 (rank : 597)
Query Neighborhood Hits	479	Target Neighborhood Hits	2000	Shared Neighborhood Hits	281
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

RON_HUMAN
θ value	θ > 10 (rank : 1228)	NC score	0.098405 (rank : 672)
Query Neighborhood Hits	479	Target Neighborhood Hits	842	Shared Neighborhood Hits	59
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 1229)	NC score	0.099736 (rank : 652)
Query Neighborhood Hits	479	Target Neighborhood Hits	836	Shared Neighborhood Hits	58
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 1230)	NC score	0.095049 (rank : 733)
Query Neighborhood Hits	479	Target Neighborhood Hits	1018	Shared Neighborhood Hits	58
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 1231)	NC score	0.095472 (rank : 727)
Query Neighborhood Hits	479	Target Neighborhood Hits	1025	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 1232)	NC score	0.095560 (rank : 725)
Query Neighborhood Hits	479	Target Neighborhood Hits	1014	Shared Neighborhood Hits	58
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 1233)	NC score	0.097769 (rank : 684)
Query Neighborhood Hits	479	Target Neighborhood Hits	1000	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 1234)	NC score	0.106198 (rank : 563)
Query Neighborhood Hits	479	Target Neighborhood Hits	907	Shared Neighborhood Hits	58
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RPGR1_HUMAN
θ value	θ > 10 (rank : 1235)	NC score	0.093472 (rank : 751)
Query Neighborhood Hits	479	Target Neighborhood Hits	578	Shared Neighborhood Hits	159
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RPGR1_MOUSE
θ value	θ > 10 (rank : 1236)	NC score	0.067232 (rank : 1041)
Query Neighborhood Hits	479	Target Neighborhood Hits	713	Shared Neighborhood Hits	154
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RRBP1_HUMAN
θ value	θ > 10 (rank : 1237)	NC score	0.103210 (rank : 599)
Query Neighborhood Hits	479	Target Neighborhood Hits	1306	Shared Neighborhood Hits	212
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RRBP1_MOUSE
θ value	θ > 10 (rank : 1238)	NC score	0.097529 (rank : 688)
Query Neighborhood Hits	479	Target Neighborhood Hits	1650	Shared Neighborhood Hits	224
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

RUFY1_HUMAN
θ value	θ > 10 (rank : 1239)	NC score	0.096590 (rank : 707)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	191
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 1240)	NC score	0.093336 (rank : 753)
Query Neighborhood Hits	479	Target Neighborhood Hits	765	Shared Neighborhood Hits	177
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_MOUSE
θ value	θ > 10 (rank : 1241)	NC score	0.099493 (rank : 658)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	199
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY3_MOUSE
θ value	θ > 10 (rank : 1242)	NC score	0.088387 (rank : 815)
Query Neighborhood Hits	479	Target Neighborhood Hits	579	Shared Neighborhood Hits	172
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUSC1_HUMAN
θ value	θ > 10 (rank : 1243)	NC score	0.090523 (rank : 789)
Query Neighborhood Hits	479	Target Neighborhood Hits	226	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	θ > 10 (rank : 1244)	NC score	0.076228 (rank : 941)
Query Neighborhood Hits	479	Target Neighborhood Hits	206	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RYK_HUMAN
θ value	θ > 10 (rank : 1245)	NC score	0.107423 (rank : 541)
Query Neighborhood Hits	479	Target Neighborhood Hits	701	Shared Neighborhood Hits	51
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 1246)	NC score	0.106677 (rank : 553)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	52
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SAFB2_HUMAN
θ value	θ > 10 (rank : 1247)	NC score	0.077524 (rank : 927)
Query Neighborhood Hits	479	Target Neighborhood Hits	720	Shared Neighborhood Hits	139
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

SAFB2_MOUSE
θ value	θ > 10 (rank : 1248)	NC score	0.072134 (rank : 991)
Query Neighborhood Hits	479	Target Neighborhood Hits	581	Shared Neighborhood Hits	129
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

SAS6_HUMAN
θ value	θ > 10 (rank : 1249)	NC score	0.124579 (rank : 407)
Query Neighborhood Hits	479	Target Neighborhood Hits	791	Shared Neighborhood Hits	194
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

SBK1_HUMAN
θ value	θ > 10 (rank : 1250)	NC score	0.054689 (rank : 1266)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 1251)	NC score	0.054751 (rank : 1263)
Query Neighborhood Hits	479	Target Neighborhood Hits	824	Shared Neighborhood Hits	58
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SDCG8_HUMAN
θ value	θ > 10 (rank : 1252)	NC score	0.110995 (rank : 502)
Query Neighborhood Hits	479	Target Neighborhood Hits	1002	Shared Neighborhood Hits	198
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SDCG8_MOUSE
θ value	θ > 10 (rank : 1253)	NC score	0.111439 (rank : 498)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	204
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SDPR_HUMAN
θ value	θ > 10 (rank : 1254)	NC score	0.050263 (rank : 1417)
Query Neighborhood Hits	479	Target Neighborhood Hits	337	Shared Neighborhood Hits	79
SwissProt Accessions	O95810	Gene names	SDPR
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein) (PS-p68).

SDPR_MOUSE
θ value	θ > 10 (rank : 1255)	NC score	0.060537 (rank : 1142)
Query Neighborhood Hits	479	Target Neighborhood Hits	485	Shared Neighborhood Hits	106
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

SEC20_MOUSE
θ value	θ > 10 (rank : 1256)	NC score	0.062326 (rank : 1110)
Query Neighborhood Hits	479	Target Neighborhood Hits	323	Shared Neighborhood Hits	116
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

SH21A_HUMAN
θ value	θ > 10 (rank : 1257)	NC score	0.205144 (rank : 158)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	69
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1258)	NC score	0.209796 (rank : 149)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	69
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1259)	NC score	0.219030 (rank : 139)
Query Neighborhood Hits	479	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1260)	NC score	0.234219 (rank : 131)
Query Neighborhood Hits	479	Target Neighborhood Hits	101	Shared Neighborhood Hits	80
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_MOUSE
θ value	θ > 10 (rank : 1261)	NC score	0.205638 (rank : 157)
Query Neighborhood Hits	479	Target Neighborhood Hits	179	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 1262)	NC score	0.157318 (rank : 242)
Query Neighborhood Hits	479	Target Neighborhood Hits	149	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH2D3_HUMAN
θ value	θ > 10 (rank : 1263)	NC score	0.158638 (rank : 239)
Query Neighborhood Hits	479	Target Neighborhood Hits	188	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 1264)	NC score	0.162248 (rank : 230)
Query Neighborhood Hits	479	Target Neighborhood Hits	174	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G1_MOUSE
θ value	θ > 10 (rank : 1265)	NC score	0.134832 (rank : 323)
Query Neighborhood Hits	479	Target Neighborhood Hits	291	Shared Neighborhood Hits	139
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 1266)	NC score	0.144914 (rank : 291)
Query Neighborhood Hits	479	Target Neighborhood Hits	324	Shared Neighborhood Hits	143
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 1267)	NC score	0.135093 (rank : 321)
Query Neighborhood Hits	479	Target Neighborhood Hits	319	Shared Neighborhood Hits	135
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 1268)	NC score	0.131738 (rank : 350)
Query Neighborhood Hits	479	Target Neighborhood Hits	222	Shared Neighborhood Hits	109
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 1269)	NC score	0.061450 (rank : 1126)
Query Neighborhood Hits	479	Target Neighborhood Hits	446	Shared Neighborhood Hits	72
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHC1_HUMAN
θ value	θ > 10 (rank : 1270)	NC score	0.265734 (rank : 109)
Query Neighborhood Hits	479	Target Neighborhood Hits	170	Shared Neighborhood Hits	110
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 1271)	NC score	0.051513 (rank : 1360)
Query Neighborhood Hits	479	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 1272)	NC score	0.053140 (rank : 1310)
Query Neighborhood Hits	479	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SKIL_HUMAN
θ value	θ > 10 (rank : 1273)	NC score	0.074358 (rank : 964)
Query Neighborhood Hits	479	Target Neighborhood Hits	460	Shared Neighborhood Hits	147
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SKIL_MOUSE
θ value	θ > 10 (rank : 1274)	NC score	0.084805 (rank : 856)
Query Neighborhood Hits	479	Target Neighborhood Hits	719	Shared Neighborhood Hits	170
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SKI_HUMAN
θ value	θ > 10 (rank : 1275)	NC score	0.058091 (rank : 1184)
Query Neighborhood Hits	479	Target Neighborhood Hits	423	Shared Neighborhood Hits	124
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

SKI_MOUSE
θ value	θ > 10 (rank : 1276)	NC score	0.059481 (rank : 1162)
Query Neighborhood Hits	479	Target Neighborhood Hits	423	Shared Neighborhood Hits	125
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

SLK_HUMAN
θ value	θ > 10 (rank : 1277)	NC score	0.082354 (rank : 874)
Query Neighborhood Hits	479	Target Neighborhood Hits	1775	Shared Neighborhood Hits	247
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 1278)	NC score	0.082140 (rank : 877)
Query Neighborhood Hits	479	Target Neighborhood Hits	1798	Shared Neighborhood Hits	244
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SMC1A_HUMAN
θ value	θ > 10 (rank : 1279)	NC score	0.134758 (rank : 324)
Query Neighborhood Hits	479	Target Neighborhood Hits	1346	Shared Neighborhood Hits	236
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	θ > 10 (rank : 1280)	NC score	0.132857 (rank : 338)
Query Neighborhood Hits	479	Target Neighborhood Hits	1384	Shared Neighborhood Hits	240
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SMC2_MOUSE
θ value	θ > 10 (rank : 1281)	NC score	0.134128 (rank : 329)
Query Neighborhood Hits	479	Target Neighborhood Hits	1131	Shared Neighborhood Hits	226
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SMC4_MOUSE
θ value	θ > 10 (rank : 1282)	NC score	0.113615 (rank : 482)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	201
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SN1L1_HUMAN
θ value	θ > 10 (rank : 1283)	NC score	0.051364 (rank : 1368)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	59
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 1284)	NC score	0.051892 (rank : 1340)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	60
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 1285)	NC score	0.054468 (rank : 1274)
Query Neighborhood Hits	479	Target Neighborhood Hits	964	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 1286)	NC score	0.054538 (rank : 1271)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNX9_HUMAN
θ value	θ > 10 (rank : 1287)	NC score	0.073767 (rank : 966)
Query Neighborhood Hits	479	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 1288)	NC score	0.071209 (rank : 997)
Query Neighborhood Hits	479	Target Neighborhood Hits	141	Shared Neighborhood Hits	56
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPAG5_HUMAN
θ value	θ > 10 (rank : 1289)	NC score	0.100358 (rank : 638)
Query Neighborhood Hits	479	Target Neighborhood Hits	625	Shared Neighborhood Hits	161
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

SPAG5_MOUSE
θ value	θ > 10 (rank : 1290)	NC score	0.104157 (rank : 588)
Query Neighborhood Hits	479	Target Neighborhood Hits	612	Shared Neighborhood Hits	165
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SPC24_HUMAN
θ value	θ > 10 (rank : 1291)	NC score	0.064285 (rank : 1082)
Query Neighborhood Hits	479	Target Neighborhood Hits	324	Shared Neighborhood Hits	109
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

SPC25_HUMAN
θ value	θ > 10 (rank : 1292)	NC score	0.056472 (rank : 1217)
Query Neighborhood Hits	479	Target Neighborhood Hits	273	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

SPC25_MOUSE
θ value	θ > 10 (rank : 1293)	NC score	0.052938 (rank : 1317)
Query Neighborhood Hits	479	Target Neighborhood Hits	241	Shared Neighborhood Hits	93
SwissProt Accessions	Q3UA16, Q9D021, Q9D1K6	Gene names	Spbc25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25.

SPN90_HUMAN
θ value	θ > 10 (rank : 1294)	NC score	0.122223 (rank : 423)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 1295)	NC score	0.111317 (rank : 499)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA1_HUMAN
θ value	θ > 10 (rank : 1296)	NC score	0.138068 (rank : 310)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	259
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 1297)	NC score	0.146624 (rank : 283)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	263
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTB1_HUMAN
θ value	θ > 10 (rank : 1298)	NC score	0.050360 (rank : 1410)
Query Neighborhood Hits	479	Target Neighborhood Hits	541	Shared Neighborhood Hits	137
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB1_MOUSE
θ value	θ > 10 (rank : 1299)	NC score	0.054462 (rank : 1275)
Query Neighborhood Hits	479	Target Neighborhood Hits	543	Shared Neighborhood Hits	153
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB2_HUMAN
θ value	θ > 10 (rank : 1300)	NC score	0.075395 (rank : 948)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	173
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	θ > 10 (rank : 1301)	NC score	0.076105 (rank : 942)
Query Neighborhood Hits	479	Target Neighborhood Hits	770	Shared Neighborhood Hits	173
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN5_HUMAN
θ value	θ > 10 (rank : 1302)	NC score	0.056752 (rank : 1210)
Query Neighborhood Hits	479	Target Neighborhood Hits	674	Shared Neighborhood Hits	163
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SRC8_HUMAN
θ value	θ > 10 (rank : 1303)	NC score	0.155773 (rank : 246)
Query Neighborhood Hits	479	Target Neighborhood Hits	269	Shared Neighborhood Hits	114
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 1304)	NC score	0.152876 (rank : 261)
Query Neighborhood Hits	479	Target Neighborhood Hits	292	Shared Neighborhood Hits	114
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRMS_HUMAN
θ value	θ > 10 (rank : 1305)	NC score	0.170906 (rank : 218)
Query Neighborhood Hits	479	Target Neighborhood Hits	946	Shared Neighborhood Hits	134
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 1306)	NC score	0.165364 (rank : 224)
Query Neighborhood Hits	479	Target Neighborhood Hits	964	Shared Neighborhood Hits	152
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STA13_MOUSE
θ value	θ > 10 (rank : 1307)	NC score	0.223616 (rank : 135)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	55
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 1308)	NC score	0.164500 (rank : 225)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	103
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1309)	NC score	0.164177 (rank : 226)
Query Neighborhood Hits	479	Target Neighborhood Hits	232	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1310)	NC score	0.167395 (rank : 221)
Query Neighborhood Hits	479	Target Neighborhood Hits	276	Shared Neighborhood Hits	114
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1311)	NC score	0.173002 (rank : 215)
Query Neighborhood Hits	479	Target Neighborhood Hits	268	Shared Neighborhood Hits	112
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 1312)	NC score	0.156985 (rank : 244)
Query Neighborhood Hits	479	Target Neighborhood Hits	271	Shared Neighborhood Hits	106
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 1313)	NC score	0.155695 (rank : 248)
Query Neighborhood Hits	479	Target Neighborhood Hits	273	Shared Neighborhood Hits	103
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 1314)	NC score	0.155618 (rank : 249)
Query Neighborhood Hits	479	Target Neighborhood Hits	288	Shared Neighborhood Hits	115
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 1315)	NC score	0.156032 (rank : 245)
Query Neighborhood Hits	479	Target Neighborhood Hits	285	Shared Neighborhood Hits	110
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STIM1_HUMAN
θ value	θ > 10 (rank : 1316)	NC score	0.070992 (rank : 1002)
Query Neighborhood Hits	479	Target Neighborhood Hits	665	Shared Neighborhood Hits	162
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM1_MOUSE
θ value	θ > 10 (rank : 1317)	NC score	0.070102 (rank : 1013)
Query Neighborhood Hits	479	Target Neighborhood Hits	660	Shared Neighborhood Hits	161
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STK16_HUMAN
θ value	θ > 10 (rank : 1318)	NC score	0.058435 (rank : 1179)
Query Neighborhood Hits	479	Target Neighborhood Hits	824	Shared Neighborhood Hits	58
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 1319)	NC score	0.059095 (rank : 1167)
Query Neighborhood Hits	479	Target Neighborhood Hits	824	Shared Neighborhood Hits	58
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 1320)	NC score	0.059227 (rank : 1165)
Query Neighborhood Hits	479	Target Neighborhood Hits	853	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 1321)	NC score	0.059623 (rank : 1155)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	58
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 1322)	NC score	0.057849 (rank : 1191)
Query Neighborhood Hits	479	Target Neighborhood Hits	853	Shared Neighborhood Hits	58
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 1323)	NC score	0.058132 (rank : 1183)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK39_HUMAN
θ value	θ > 10 (rank : 1324)	NC score	0.062194 (rank : 1111)
Query Neighborhood Hits	479	Target Neighborhood Hits	882	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 1325)	NC score	0.062093 (rank : 1114)
Query Neighborhood Hits	479	Target Neighborhood Hits	915	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 1326)	NC score	0.054483 (rank : 1273)
Query Neighborhood Hits	479	Target Neighborhood Hits	861	Shared Neighborhood Hits	62
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 1327)	NC score	0.054365 (rank : 1277)
Query Neighborhood Hits	479	Target Neighborhood Hits	869	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 1328)	NC score	0.054136 (rank : 1285)
Query Neighborhood Hits	479	Target Neighborhood Hits	870	Shared Neighborhood Hits	61
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 1329)	NC score	0.054053 (rank : 1287)
Query Neighborhood Hits	479	Target Neighborhood Hits	873	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STS1_HUMAN
θ value	θ > 10 (rank : 1330)	NC score	0.069750 (rank : 1019)
Query Neighborhood Hits	479	Target Neighborhood Hits	106	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STXB4_HUMAN
θ value	θ > 10 (rank : 1331)	NC score	0.062779 (rank : 1102)
Query Neighborhood Hits	479	Target Neighborhood Hits	616	Shared Neighborhood Hits	143
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 1332)	NC score	0.058420 (rank : 1180)
Query Neighborhood Hits	479	Target Neighborhood Hits	629	Shared Neighborhood Hits	150
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STYK1_HUMAN
θ value	θ > 10 (rank : 1333)	NC score	0.110426 (rank : 511)
Query Neighborhood Hits	479	Target Neighborhood Hits	786	Shared Neighborhood Hits	58
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 1334)	NC score	0.109791 (rank : 521)
Query Neighborhood Hits	479	Target Neighborhood Hits	779	Shared Neighborhood Hits	58
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SURF6_MOUSE
θ value	θ > 10 (rank : 1335)	NC score	0.054931 (rank : 1259)
Query Neighborhood Hits	479	Target Neighborhood Hits	195	Shared Neighborhood Hits	71
SwissProt Accessions	P70279, Q8BPI4, Q8BRL7, Q8R0Q7	Gene names	Surf6, Surf-6
Domain Architecture
Description	Surfeit locus protein 6.

SWP70_HUMAN
θ value	θ > 10 (rank : 1336)	NC score	0.117212 (rank : 457)
Query Neighborhood Hits	479	Target Neighborhood Hits	973	Shared Neighborhood Hits	211
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 1337)	NC score	0.116561 (rank : 463)
Query Neighborhood Hits	479	Target Neighborhood Hits	1097	Shared Neighborhood Hits	217
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_MOUSE
θ value	θ > 10 (rank : 1338)	NC score	0.130879 (rank : 359)
Query Neighborhood Hits	479	Target Neighborhood Hits	1456	Shared Neighborhood Hits	238
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE2_HUMAN
θ value	θ > 10 (rank : 1339)	NC score	0.096514 (rank : 708)
Query Neighborhood Hits	479	Target Neighborhood Hits	1323	Shared Neighborhood Hits	222
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

T3JAM_HUMAN
θ value	θ > 10 (rank : 1340)	NC score	0.093499 (rank : 750)
Query Neighborhood Hits	479	Target Neighborhood Hits	533	Shared Neighborhood Hits	144
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

T3JAM_MOUSE
θ value	θ > 10 (rank : 1341)	NC score	0.096195 (rank : 714)
Query Neighborhood Hits	479	Target Neighborhood Hits	535	Shared Neighborhood Hits	164
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TACC1_HUMAN
θ value	θ > 10 (rank : 1342)	NC score	0.107037 (rank : 548)
Query Neighborhood Hits	479	Target Neighborhood Hits	597	Shared Neighborhood Hits	159
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TACC1_MOUSE
θ value	θ > 10 (rank : 1343)	NC score	0.104227 (rank : 587)
Query Neighborhood Hits	479	Target Neighborhood Hits	667	Shared Neighborhood Hits	161
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TAF7_HUMAN
θ value	θ > 10 (rank : 1344)	NC score	0.056343 (rank : 1224)
Query Neighborhood Hits	479	Target Neighborhood Hits	222	Shared Neighborhood Hits	92
SwissProt Accessions	Q15545, Q13036	Gene names	TAF7, TAF2F, TAFII55
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

TAOK2_HUMAN
θ value	θ > 10 (rank : 1345)	NC score	0.068152 (rank : 1035)
Query Neighborhood Hits	479	Target Neighborhood Hits	1172	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 1346)	NC score	0.079242 (rank : 910)
Query Neighborhood Hits	479	Target Neighborhood Hits	1373	Shared Neighborhood Hits	195
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 1347)	NC score	0.082222 (rank : 876)
Query Neighborhood Hits	479	Target Neighborhood Hits	1494	Shared Neighborhood Hits	216
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 1348)	NC score	0.079778 (rank : 901)
Query Neighborhood Hits	479	Target Neighborhood Hits	1458	Shared Neighborhood Hits	212
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TARA_HUMAN
θ value	θ > 10 (rank : 1349)	NC score	0.053305 (rank : 1304)
Query Neighborhood Hits	479	Target Neighborhood Hits	1626	Shared Neighborhood Hits	175
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARA_MOUSE
θ value	θ > 10 (rank : 1350)	NC score	0.069673 (rank : 1024)
Query Neighborhood Hits	479	Target Neighborhood Hits	1133	Shared Neighborhood Hits	171
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TAXB1_HUMAN
θ value	θ > 10 (rank : 1351)	NC score	0.129930 (rank : 365)
Query Neighborhood Hits	479	Target Neighborhood Hits	829	Shared Neighborhood Hits	199
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TBK1_HUMAN
θ value	θ > 10 (rank : 1352)	NC score	0.054360 (rank : 1278)
Query Neighborhood Hits	479	Target Neighborhood Hits	861	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 1353)	NC score	0.055780 (rank : 1234)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TCRG1_HUMAN
θ value	θ > 10 (rank : 1354)	NC score	0.085191 (rank : 850)
Query Neighborhood Hits	479	Target Neighborhood Hits	929	Shared Neighborhood Hits	160
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 1355)	NC score	0.085121 (rank : 852)
Query Neighborhood Hits	479	Target Neighborhood Hits	947	Shared Neighborhood Hits	161
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TEKT2_MOUSE
θ value	θ > 10 (rank : 1356)	NC score	0.051615 (rank : 1355)
Query Neighborhood Hits	479	Target Neighborhood Hits	199	Shared Neighborhood Hits	91
SwissProt Accessions	Q922G7, Q9WVR0	Gene names	Tekt2
Domain Architecture
Description	Tektin-2 (Testicular tektin) (Tektin-t).

TESK1_HUMAN
θ value	θ > 10 (rank : 1357)	NC score	0.070363 (rank : 1009)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	61
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 1358)	NC score	0.070530 (rank : 1007)
Query Neighborhood Hits	479	Target Neighborhood Hits	862	Shared Neighborhood Hits	59
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 1359)	NC score	0.074014 (rank : 965)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 1360)	NC score	0.072965 (rank : 980)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 1361)	NC score	0.100670 (rank : 630)
Query Neighborhood Hits	479	Target Neighborhood Hits	1103	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1362)	NC score	0.110887 (rank : 504)
Query Neighborhood Hits	479	Target Neighborhood Hits	1333	Shared Neighborhood Hits	159
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 1363)	NC score	0.071107 (rank : 1000)
Query Neighborhood Hits	479	Target Neighborhood Hits	755	Shared Neighborhood Hits	58
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 1364)	NC score	0.071014 (rank : 1001)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	58
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 1365)	NC score	0.051841 (rank : 1344)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	58
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 1366)	NC score	0.051835 (rank : 1345)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	58
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TIAM1_HUMAN
θ value	θ > 10 (rank : 1367)	NC score	0.062346 (rank : 1109)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	29
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 1368)	NC score	0.062434 (rank : 1105)
Query Neighborhood Hits	479	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE1_HUMAN
θ value	θ > 10 (rank : 1369)	NC score	0.092663 (rank : 759)
Query Neighborhood Hits	479	Target Neighborhood Hits	1241	Shared Neighborhood Hits	61
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 1370)	NC score	0.092366 (rank : 762)
Query Neighborhood Hits	479	Target Neighborhood Hits	1266	Shared Neighborhood Hits	61
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 1371)	NC score	0.092355 (rank : 763)
Query Neighborhood Hits	479	Target Neighborhood Hits	1192	Shared Neighborhood Hits	61
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 1372)	NC score	0.092241 (rank : 764)
Query Neighborhood Hits	479	Target Neighborhood Hits	1204	Shared Neighborhood Hits	61
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TLK1_HUMAN
θ value	θ > 10 (rank : 1373)	NC score	0.050795 (rank : 1394)
Query Neighborhood Hits	479	Target Neighborhood Hits	967	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 1374)	NC score	0.050936 (rank : 1392)
Query Neighborhood Hits	479	Target Neighborhood Hits	947	Shared Neighborhood Hits	121
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 1375)	NC score	0.056211 (rank : 1228)
Query Neighborhood Hits	479	Target Neighborhood Hits	1044	Shared Neighborhood Hits	138
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 1376)	NC score	0.060520 (rank : 1143)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	165
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TMF1_HUMAN
θ value	θ > 10 (rank : 1377)	NC score	0.124700 (rank : 405)
Query Neighborhood Hits	479	Target Neighborhood Hits	987	Shared Neighborhood Hits	216
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TNI3K_HUMAN
θ value	θ > 10 (rank : 1378)	NC score	0.071196 (rank : 998)
Query Neighborhood Hits	479	Target Neighborhood Hits	1084	Shared Neighborhood Hits	63
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 1379)	NC score	0.071572 (rank : 995)
Query Neighborhood Hits	479	Target Neighborhood Hits	1079	Shared Neighborhood Hits	63
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 1380)	NC score	0.074835 (rank : 956)
Query Neighborhood Hits	479	Target Neighborhood Hits	1570	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNIP3_HUMAN
θ value	θ > 10 (rank : 1381)	NC score	0.132695 (rank : 339)
Query Neighborhood Hits	479	Target Neighborhood Hits	511	Shared Neighborhood Hits	163
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

TNK1_HUMAN
θ value	θ > 10 (rank : 1382)	NC score	0.102330 (rank : 607)
Query Neighborhood Hits	479	Target Neighborhood Hits	815	Shared Neighborhood Hits	62
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1383)	NC score	0.102315 (rank : 608)
Query Neighborhood Hits	479	Target Neighborhood Hits	806	Shared Neighborhood Hits	66
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TNNT2_HUMAN
θ value	θ > 10 (rank : 1384)	NC score	0.086146 (rank : 841)
Query Neighborhood Hits	479	Target Neighborhood Hits	433	Shared Neighborhood Hits	132
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TNNT2_MOUSE
θ value	θ > 10 (rank : 1385)	NC score	0.061399 (rank : 1129)
Query Neighborhood Hits	479	Target Neighborhood Hits	395	Shared Neighborhood Hits	130
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TNNT3_HUMAN
θ value	θ > 10 (rank : 1386)	NC score	0.063140 (rank : 1096)
Query Neighborhood Hits	479	Target Neighborhood Hits	327	Shared Neighborhood Hits	114
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

TNNT3_MOUSE
θ value	θ > 10 (rank : 1387)	NC score	0.057512 (rank : 1196)
Query Neighborhood Hits	479	Target Neighborhood Hits	317	Shared Neighborhood Hits	103
SwissProt Accessions	Q9QZ47, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46	Gene names	Tnnt3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT).

TOPK_HUMAN
θ value	θ > 10 (rank : 1388)	NC score	0.069187 (rank : 1027)
Query Neighborhood Hits	479	Target Neighborhood Hits	605	Shared Neighborhood Hits	49
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1389)	NC score	0.067328 (rank : 1040)
Query Neighborhood Hits	479	Target Neighborhood Hits	618	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TPM1_MOUSE
θ value	θ > 10 (rank : 1390)	NC score	0.104101 (rank : 590)
Query Neighborhood Hits	479	Target Neighborhood Hits	729	Shared Neighborhood Hits	195
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM2_HUMAN
θ value	θ > 10 (rank : 1391)	NC score	0.108476 (rank : 532)
Query Neighborhood Hits	479	Target Neighborhood Hits	677	Shared Neighborhood Hits	189
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_MOUSE
θ value	θ > 10 (rank : 1392)	NC score	0.105631 (rank : 568)
Query Neighborhood Hits	479	Target Neighborhood Hits	676	Shared Neighborhood Hits	190
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM3_HUMAN
θ value	θ > 10 (rank : 1393)	NC score	0.105089 (rank : 573)
Query Neighborhood Hits	479	Target Neighborhood Hits	689	Shared Neighborhood Hits	184
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
θ value	θ > 10 (rank : 1394)	NC score	0.105387 (rank : 570)
Query Neighborhood Hits	479	Target Neighborhood Hits	676	Shared Neighborhood Hits	183
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

TPM4_HUMAN
θ value	θ > 10 (rank : 1395)	NC score	0.098943 (rank : 664)
Query Neighborhood Hits	479	Target Neighborhood Hits	525	Shared Neighborhood Hits	160
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

TPM4_MOUSE
θ value	θ > 10 (rank : 1396)	NC score	0.099527 (rank : 655)
Query Neighborhood Hits	479	Target Neighborhood Hits	703	Shared Neighborhood Hits	185
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

TRAIP_HUMAN
θ value	θ > 10 (rank : 1397)	NC score	0.090202 (rank : 791)
Query Neighborhood Hits	479	Target Neighborhood Hits	780	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRAIP_MOUSE
θ value	θ > 10 (rank : 1398)	NC score	0.090595 (rank : 788)
Query Neighborhood Hits	479	Target Neighborhood Hits	745	Shared Neighborhood Hits	171
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TRAK1_HUMAN
θ value	θ > 10 (rank : 1399)	NC score	0.096084 (rank : 716)
Query Neighborhood Hits	479	Target Neighborhood Hits	660	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

TRAK2_HUMAN
θ value	θ > 10 (rank : 1400)	NC score	0.090880 (rank : 779)
Query Neighborhood Hits	479	Target Neighborhood Hits	476	Shared Neighborhood Hits	150
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

TRDN_HUMAN
θ value	θ > 10 (rank : 1401)	NC score	0.058235 (rank : 1182)
Query Neighborhood Hits	479	Target Neighborhood Hits	542	Shared Neighborhood Hits	103
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

TRIO_HUMAN
θ value	θ > 10 (rank : 1402)	NC score	0.075526 (rank : 947)
Query Neighborhood Hits	479	Target Neighborhood Hits	1580	Shared Neighborhood Hits	198
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSC1_HUMAN
θ value	θ > 10 (rank : 1403)	NC score	0.102283 (rank : 609)
Query Neighborhood Hits	479	Target Neighborhood Hits	765	Shared Neighborhood Hits	176
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

TSSK1_MOUSE
θ value	θ > 10 (rank : 1404)	NC score	0.052542 (rank : 1328)
Query Neighborhood Hits	479	Target Neighborhood Hits	835	Shared Neighborhood Hits	60
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 1405)	NC score	0.050683 (rank : 1397)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK4_HUMAN
θ value	θ > 10 (rank : 1406)	NC score	0.054198 (rank : 1283)
Query Neighborhood Hits	479	Target Neighborhood Hits	836	Shared Neighborhood Hits	58
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 1407)	NC score	0.053179 (rank : 1309)
Query Neighborhood Hits	479	Target Neighborhood Hits	840	Shared Neighborhood Hits	58
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TTBK1_HUMAN
θ value	θ > 10 (rank : 1408)	NC score	0.062162 (rank : 1112)
Query Neighborhood Hits	479	Target Neighborhood Hits	1058	Shared Neighborhood Hits	72
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 1409)	NC score	0.050771 (rank : 1395)
Query Neighborhood Hits	479	Target Neighborhood Hits	822	Shared Neighborhood Hits	59
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 1410)	NC score	0.051402 (rank : 1365)
Query Neighborhood Hits	479	Target Neighborhood Hits	811	Shared Neighborhood Hits	59
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTC3_HUMAN
θ value	θ > 10 (rank : 1411)	NC score	0.082391 (rank : 873)
Query Neighborhood Hits	479	Target Neighborhood Hits	664	Shared Neighborhood Hits	164
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

TTK_HUMAN
θ value	θ > 10 (rank : 1412)	NC score	0.050971 (rank : 1388)
Query Neighborhood Hits	479	Target Neighborhood Hits	816	Shared Neighborhood Hits	60
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TXLNA_HUMAN
θ value	θ > 10 (rank : 1413)	NC score	0.095292 (rank : 729)
Query Neighborhood Hits	479	Target Neighborhood Hits	982	Shared Neighborhood Hits	187
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNA_MOUSE
θ value	θ > 10 (rank : 1414)	NC score	0.100304 (rank : 640)
Query Neighborhood Hits	479	Target Neighborhood Hits	846	Shared Neighborhood Hits	197
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNB_HUMAN
θ value	θ > 10 (rank : 1415)	NC score	0.098185 (rank : 675)
Query Neighborhood Hits	479	Target Neighborhood Hits	912	Shared Neighborhood Hits	175
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

TXLNB_MOUSE
θ value	θ > 10 (rank : 1416)	NC score	0.097425 (rank : 690)
Query Neighborhood Hits	479	Target Neighborhood Hits	640	Shared Neighborhood Hits	169
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

TXLNG_HUMAN
θ value	θ > 10 (rank : 1417)	NC score	0.109984 (rank : 517)
Query Neighborhood Hits	479	Target Neighborhood Hits	568	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

TXLNG_MOUSE
θ value	θ > 10 (rank : 1418)	NC score	0.115174 (rank : 470)
Query Neighborhood Hits	479	Target Neighborhood Hits	552	Shared Neighborhood Hits	175
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

TYK2_HUMAN
θ value	θ > 10 (rank : 1419)	NC score	0.088116 (rank : 820)
Query Neighborhood Hits	479	Target Neighborhood Hits	841	Shared Neighborhood Hits	58
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1420)	NC score	0.089509 (rank : 798)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 1421)	NC score	0.096204 (rank : 713)
Query Neighborhood Hits	479	Target Neighborhood Hits	995	Shared Neighborhood Hits	58
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 1422)	NC score	0.096475 (rank : 709)
Query Neighborhood Hits	479	Target Neighborhood Hits	1007	Shared Neighborhood Hits	58
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

U2AFM_MOUSE
θ value	θ > 10 (rank : 1423)	NC score	0.062083 (rank : 1115)
Query Neighborhood Hits	479	Target Neighborhood Hits	543	Shared Neighborhood Hits	140
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

UFO_HUMAN
θ value	θ > 10 (rank : 1424)	NC score	0.099510 (rank : 656)
Query Neighborhood Hits	479	Target Neighborhood Hits	981	Shared Neighborhood Hits	61
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 1425)	NC score	0.098499 (rank : 670)
Query Neighborhood Hits	479	Target Neighborhood Hits	988	Shared Neighborhood Hits	59
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ULK1_HUMAN
θ value	θ > 10 (rank : 1426)	NC score	0.053565 (rank : 1298)
Query Neighborhood Hits	479	Target Neighborhood Hits	1121	Shared Neighborhood Hits	67
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 1427)	NC score	0.055428 (rank : 1240)
Query Neighborhood Hits	479	Target Neighborhood Hits	1214	Shared Neighborhood Hits	77
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 1428)	NC score	0.053645 (rank : 1296)
Query Neighborhood Hits	479	Target Neighborhood Hits	979	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 1429)	NC score	0.053869 (rank : 1292)
Query Neighborhood Hits	479	Target Neighborhood Hits	943	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 1430)	NC score	0.051340 (rank : 1371)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	58
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 1431)	NC score	0.050223 (rank : 1421)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	62
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

UN13A_HUMAN
θ value	θ > 10 (rank : 1432)	NC score	0.051210 (rank : 1380)
Query Neighborhood Hits	479	Target Neighborhood Hits	285	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UTRO_HUMAN
θ value	θ > 10 (rank : 1433)	NC score	0.083465 (rank : 866)
Query Neighborhood Hits	479	Target Neighborhood Hits	960	Shared Neighborhood Hits	197
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

VDP_HUMAN
θ value	θ > 10 (rank : 1434)	NC score	0.096693 (rank : 703)
Query Neighborhood Hits	479	Target Neighborhood Hits	645	Shared Neighborhood Hits	166
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

VDP_MOUSE
θ value	θ > 10 (rank : 1435)	NC score	0.086015 (rank : 842)
Query Neighborhood Hits	479	Target Neighborhood Hits	469	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

VGFR1_HUMAN
θ value	θ > 10 (rank : 1436)	NC score	0.084993 (rank : 853)
Query Neighborhood Hits	479	Target Neighborhood Hits	1109	Shared Neighborhood Hits	58
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 1437)	NC score	0.084817 (rank : 855)
Query Neighborhood Hits	479	Target Neighborhood Hits	1118	Shared Neighborhood Hits	58
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 1438)	NC score	0.086870 (rank : 832)
Query Neighborhood Hits	479	Target Neighborhood Hits	1103	Shared Neighborhood Hits	58
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 1439)	NC score	0.086938 (rank : 829)
Query Neighborhood Hits	479	Target Neighborhood Hits	1089	Shared Neighborhood Hits	58
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 1440)	NC score	0.089360 (rank : 800)
Query Neighborhood Hits	479	Target Neighborhood Hits	1037	Shared Neighborhood Hits	58
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 1441)	NC score	0.089637 (rank : 795)
Query Neighborhood Hits	479	Target Neighborhood Hits	1056	Shared Neighborhood Hits	58
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VIME_HUMAN
θ value	θ > 10 (rank : 1442)	NC score	0.064479 (rank : 1077)
Query Neighborhood Hits	479	Target Neighborhood Hits	706	Shared Neighborhood Hits	197
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

VIME_MOUSE
θ value	θ > 10 (rank : 1443)	NC score	0.066652 (rank : 1049)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	198
SwissProt Accessions	P20152, O08704, Q8CCH1	Gene names	Vim
Domain Architecture
Description	Vimentin.

WDR67_HUMAN
θ value	θ > 10 (rank : 1444)	NC score	0.073720 (rank : 969)
Query Neighborhood Hits	479	Target Neighborhood Hits	782	Shared Neighborhood Hits	156
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

WDR67_MOUSE
θ value	θ > 10 (rank : 1445)	NC score	0.054687 (rank : 1267)
Query Neighborhood Hits	479	Target Neighborhood Hits	476	Shared Neighborhood Hits	119
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

WNK1_HUMAN
θ value	θ > 10 (rank : 1446)	NC score	0.053003 (rank : 1315)
Query Neighborhood Hits	479	Target Neighborhood Hits	1158	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 1447)	NC score	0.052782 (rank : 1322)
Query Neighborhood Hits	479	Target Neighborhood Hits	1179	Shared Neighborhood Hits	72
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 1448)	NC score	0.055141 (rank : 1250)
Query Neighborhood Hits	479	Target Neighborhood Hits	1407	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 1449)	NC score	0.053647 (rank : 1295)
Query Neighborhood Hits	479	Target Neighborhood Hits	948	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WTAP_HUMAN
θ value	θ > 10 (rank : 1450)	NC score	0.053050 (rank : 1313)
Query Neighborhood Hits	479	Target Neighborhood Hits	262	Shared Neighborhood Hits	92
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

WTAP_MOUSE
θ value	θ > 10 (rank : 1451)	NC score	0.050614 (rank : 1400)
Query Neighborhood Hits	479	Target Neighborhood Hits	250	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ER69	Gene names	Wtap
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

YO11_MOUSE
θ value	θ > 10 (rank : 1452)	NC score	0.059376 (rank : 1164)
Query Neighborhood Hits	479	Target Neighborhood Hits	272	Shared Neighborhood Hits	91
SwissProt Accessions	P11260	Gene names
Domain Architecture
Description	Hypothetical protein ORF-1137.

YSK4_HUMAN
θ value	θ > 10 (rank : 1453)	NC score	0.057244 (rank : 1201)
Query Neighborhood Hits	479	Target Neighborhood Hits	921	Shared Neighborhood Hits	64
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZC313_HUMAN
θ value	θ > 10 (rank : 1454)	NC score	0.062821 (rank : 1101)
Query Neighborhood Hits	479	Target Neighborhood Hits	772	Shared Neighborhood Hits	123
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZRF1_HUMAN
θ value	θ > 10 (rank : 1455)	NC score	0.061904 (rank : 1116)
Query Neighborhood Hits	479	Target Neighborhood Hits	457	Shared Neighborhood Hits	116
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

ZRF1_MOUSE
θ value	θ > 10 (rank : 1456)	NC score	0.066640 (rank : 1050)
Query Neighborhood Hits	479	Target Neighborhood Hits	414	Shared Neighborhood Hits	116
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

ZWINT_MOUSE
θ value	θ > 10 (rank : 1457)	NC score	0.080854 (rank : 889)
Query Neighborhood Hits	479	Target Neighborhood Hits	497	Shared Neighborhood Hits	147
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

Hits sorted by NC score

P85A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	479	Target Neighborhood Hits	479	Shared Neighborhood Hits	479
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.991345 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	408
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
NC score	0.870841 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	479	Target Neighborhood Hits	543	Shared Neighborhood Hits	302
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
NC score	0.865028 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	479	Target Neighborhood Hits	519	Shared Neighborhood Hits	304
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_HUMAN
NC score	0.854723 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	479	Target Neighborhood Hits	451	Shared Neighborhood Hits	268
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.854341 (rank : 6)	θ value	0 (rank : 2)
Query Neighborhood Hits	479	Target Neighborhood Hits	401	Shared Neighborhood Hits	249
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CHIN_MOUSE
NC score	0.501236 (rank : 7)	θ value	2.0648e-12 (rank : 8)
Query Neighborhood Hits	479	Target Neighborhood Hits	229	Shared Neighborhood Hits	147
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.489112 (rank : 8)	θ value	3.52202e-12 (rank : 11)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	138
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.483749 (rank : 9)	θ value	4.59992e-12 (rank : 12)
Query Neighborhood Hits	479	Target Neighborhood Hits	220	Shared Neighborhood Hits	132
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

DAPP1_MOUSE
NC score	0.472613 (rank : 10)	θ value	2.36244e-08 (rank : 22)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SOCS2_MOUSE
NC score	0.468081 (rank : 11)	θ value	1.38499e-08 (rank : 19)
Query Neighborhood Hits	479	Target Neighborhood Hits	94	Shared Neighborhood Hits	82
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS2_HUMAN
NC score	0.461192 (rank : 12)	θ value	2.36244e-08 (rank : 23)
Query Neighborhood Hits	479	Target Neighborhood Hits	104	Shared Neighborhood Hits	82
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

DAPP1_HUMAN
NC score	0.455929 (rank : 13)	θ value	2.21117e-06 (rank : 53)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RHG09_HUMAN
NC score	0.442862 (rank : 14)	θ value	1.133e-10 (rank : 13)
Query Neighborhood Hits	479	Target Neighborhood Hits	186	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

NCK2_HUMAN
NC score	0.440637 (rank : 15)	θ value	0.000158464 (rank : 102)
Query Neighborhood Hits	479	Target Neighborhood Hits	310	Shared Neighborhood Hits	182
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GMIP_HUMAN
NC score	0.438566 (rank : 16)	θ value	9.59137e-10 (rank : 14)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRB2_MOUSE
NC score	0.437456 (rank : 17)	θ value	0.00020696 (rank : 104)
Query Neighborhood Hits	479	Target Neighborhood Hits	312	Shared Neighborhood Hits	170
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.436918 (rank : 18)	θ value	0.00020696 (rank : 103)
Query Neighborhood Hits	479	Target Neighborhood Hits	310	Shared Neighborhood Hits	168
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GMIP_MOUSE
NC score	0.436661 (rank : 19)	θ value	1.25267e-09 (rank : 16)
Query Neighborhood Hits	479	Target Neighborhood Hits	202	Shared Neighborhood Hits	81
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SOCS6_MOUSE
NC score	0.432129 (rank : 20)	θ value	1.99992e-07 (rank : 36)
Query Neighborhood Hits	479	Target Neighborhood Hits	146	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_HUMAN
NC score	0.431614 (rank : 21)	θ value	1.99992e-07 (rank : 35)
Query Neighborhood Hits	479	Target Neighborhood Hits	126	Shared Neighborhood Hits	84
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

GRAP_MOUSE
NC score	0.421225 (rank : 22)	θ value	0.00390308 (rank : 143)
Query Neighborhood Hits	479	Target Neighborhood Hits	309	Shared Neighborhood Hits	160
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

TCGAP_MOUSE
NC score	0.420728 (rank : 23)	θ value	8.11959e-09 (rank : 18)
Query Neighborhood Hits	479	Target Neighborhood Hits	409	Shared Neighborhood Hits	115
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG12_HUMAN
NC score	0.420703 (rank : 24)	θ value	6.87365e-08 (rank : 27)
Query Neighborhood Hits	479	Target Neighborhood Hits	190	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CISH_HUMAN
NC score	0.419786 (rank : 25)	θ value	1.87187e-05 (rank : 72)
Query Neighborhood Hits	479	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

RHG12_MOUSE
NC score	0.419763 (rank : 26)	θ value	6.87365e-08 (rank : 28)
Query Neighborhood Hits	479	Target Neighborhood Hits	204	Shared Neighborhood Hits	94
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CISH_MOUSE
NC score	0.415558 (rank : 27)	θ value	1.87187e-05 (rank : 73)
Query Neighborhood Hits	479	Target Neighborhood Hits	94	Shared Neighborhood Hits	82
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CRKL_HUMAN
NC score	0.415533 (rank : 28)	θ value	0.000270298 (rank : 109)
Query Neighborhood Hits	479	Target Neighborhood Hits	313	Shared Neighborhood Hits	171
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.414264 (rank : 29)	θ value	0.00035302 (rank : 111)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	169
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SOCS7_MOUSE
NC score	0.413855 (rank : 30)	θ value	1.09739e-05 (rank : 69)
Query Neighborhood Hits	479	Target Neighborhood Hits	154	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

RHG26_HUMAN
NC score	0.413842 (rank : 31)	θ value	2.44474e-05 (rank : 79)
Query Neighborhood Hits	479	Target Neighborhood Hits	281	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CHIO_MOUSE
NC score	0.413778 (rank : 32)	θ value	2.0648e-12 (rank : 9)
Query Neighborhood Hits	479	Target Neighborhood Hits	130	Shared Neighborhood Hits	67
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GRAP_HUMAN
NC score	0.413240 (rank : 33)	θ value	0.0252991 (rank : 175)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	158
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SHE_HUMAN
NC score	0.410510 (rank : 34)	θ value	9.29e-05 (rank : 92)
Query Neighborhood Hits	479	Target Neighborhood Hits	164	Shared Neighborhood Hits	112
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
NC score	0.410216 (rank : 35)	θ value	7.1131e-05 (rank : 89)
Query Neighborhood Hits	479	Target Neighborhood Hits	169	Shared Neighborhood Hits	119
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

VAV3_MOUSE
NC score	0.409881 (rank : 36)	θ value	9.59137e-10 (rank : 15)
Query Neighborhood Hits	479	Target Neighborhood Hits	404	Shared Neighborhood Hits	175
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PLCG2_HUMAN
NC score	0.407178 (rank : 37)	θ value	1.53129e-07 (rank : 33)
Query Neighborhood Hits	479	Target Neighborhood Hits	280	Shared Neighborhood Hits	160
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

CRK_HUMAN
NC score	0.405663 (rank : 38)	θ value	0.000461057 (rank : 113)
Query Neighborhood Hits	479	Target Neighborhood Hits	308	Shared Neighborhood Hits	171
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

RGAP1_HUMAN
NC score	0.405583 (rank : 39)	θ value	5.44631e-05 (rank : 88)
Query Neighborhood Hits	479	Target Neighborhood Hits	189	Shared Neighborhood Hits	102
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

VAV3_HUMAN
NC score	0.405253 (rank : 40)	θ value	1.38499e-08 (rank : 20)
Query Neighborhood Hits	479	Target Neighborhood Hits	398	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CRK_MOUSE
NC score	0.403484 (rank : 41)	θ value	0.000461057 (rank : 114)
Query Neighborhood Hits	479	Target Neighborhood Hits	314	Shared Neighborhood Hits	171
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SLAP2_MOUSE
NC score	0.400213 (rank : 42)	θ value	0.000602161 (rank : 121)
Query Neighborhood Hits	479	Target Neighborhood Hits	136	Shared Neighborhood Hits	110
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ABR_HUMAN
NC score	0.398611 (rank : 43)	θ value	5.26297e-08 (rank : 26)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

PLCG1_HUMAN
NC score	0.398125 (rank : 44)	θ value	2.88788e-06 (rank : 57)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	173
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RHG04_HUMAN
NC score	0.397834 (rank : 45)	θ value	0.00509761 (rank : 148)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	160
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PLCG1_MOUSE
NC score	0.397076 (rank : 46)	θ value	2.88788e-06 (rank : 58)
Query Neighborhood Hits	479	Target Neighborhood Hits	314	Shared Neighborhood Hits	176
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RGAP1_MOUSE
NC score	0.395640 (rank : 47)	θ value	2.21117e-06 (rank : 54)
Query Neighborhood Hits	479	Target Neighborhood Hits	185	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

GRAP2_MOUSE
NC score	0.395408 (rank : 48)	θ value	0.00390308 (rank : 142)
Query Neighborhood Hits	479	Target Neighborhood Hits	297	Shared Neighborhood Hits	157
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SHB_HUMAN
NC score	0.394052 (rank : 49)	θ value	1.43324e-05 (rank : 70)
Query Neighborhood Hits	479	Target Neighborhood Hits	141	Shared Neighborhood Hits	112
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
NC score	0.393736 (rank : 50)	θ value	1.43324e-05 (rank : 71)
Query Neighborhood Hits	479	Target Neighborhood Hits	137	Shared Neighborhood Hits	111
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

RHG25_MOUSE
NC score	0.391975 (rank : 51)	θ value	4.0297e-08 (rank : 25)
Query Neighborhood Hits	479	Target Neighborhood Hits	492	Shared Neighborhood Hits	168
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

GRAP2_HUMAN
NC score	0.391317 (rank : 52)	θ value	0.0148317 (rank : 168)
Query Neighborhood Hits	479	Target Neighborhood Hits	304	Shared Neighborhood Hits	157
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SHD_MOUSE
NC score	0.391146 (rank : 53)	θ value	0.000121331 (rank : 97)
Query Neighborhood Hits	479	Target Neighborhood Hits	137	Shared Neighborhood Hits	108
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

GRLF1_HUMAN
NC score	0.388942 (rank : 54)	θ value	2.13673e-09 (rank : 17)
Query Neighborhood Hits	479	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RHG25_HUMAN
NC score	0.388882 (rank : 55)	θ value	1.17247e-07 (rank : 32)
Query Neighborhood Hits	479	Target Neighborhood Hits	550	Shared Neighborhood Hits	199
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SRGP2_HUMAN
NC score	0.386707 (rank : 56)	θ value	0.00509761 (rank : 153)
Query Neighborhood Hits	479	Target Neighborhood Hits	331	Shared Neighborhood Hits	174
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RBP1_HUMAN
NC score	0.386603 (rank : 57)	θ value	3.41135e-07 (rank : 38)
Query Neighborhood Hits	479	Target Neighborhood Hits	521	Shared Neighborhood Hits	198
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

FNBP2_HUMAN
NC score	0.385932 (rank : 58)	θ value	0.0148317 (rank : 167)
Query Neighborhood Hits	479	Target Neighborhood Hits	432	Shared Neighborhood Hits	210
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RBP1_MOUSE
NC score	0.383267 (rank : 59)	θ value	6.43352e-06 (rank : 65)
Query Neighborhood Hits	479	Target Neighborhood Hits	493	Shared Neighborhood Hits	185
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG05_MOUSE
NC score	0.382709 (rank : 60)	θ value	3.41135e-07 (rank : 39)
Query Neighborhood Hits	479	Target Neighborhood Hits	165	Shared Neighborhood Hits	82
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

SRGP2_MOUSE
NC score	0.381723 (rank : 61)	θ value	0.0431538 (rank : 190)
Query Neighborhood Hits	479	Target Neighborhood Hits	324	Shared Neighborhood Hits	176
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

NCK1_HUMAN
NC score	0.381220 (rank : 62)	θ value	θ > 10 (rank : 1096)
Query Neighborhood Hits	479	Target Neighborhood Hits	312	Shared Neighborhood Hits	175
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SLAP1_MOUSE
NC score	0.380645 (rank : 63)	θ value	0.00102713 (rank : 128)
Query Neighborhood Hits	479	Target Neighborhood Hits	117	Shared Neighborhood Hits	92
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

VAV2_HUMAN
NC score	0.379911 (rank : 64)	θ value	5.81887e-07 (rank : 44)
Query Neighborhood Hits	479	Target Neighborhood Hits	453	Shared Neighborhood Hits	189
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SRGP1_HUMAN
NC score	0.379861 (rank : 65)	θ value	0.00298849 (rank : 140)
Query Neighborhood Hits	479	Target Neighborhood Hits	390	Shared Neighborhood Hits	194
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RHG05_HUMAN
NC score	0.379721 (rank : 66)	θ value	8.97725e-08 (rank : 29)
Query Neighborhood Hits	479	Target Neighborhood Hits	158	Shared Neighborhood Hits	77
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

SLAP2_HUMAN
NC score	0.377984 (rank : 67)	θ value	0.0193708 (rank : 174)
Query Neighborhood Hits	479	Target Neighborhood Hits	139	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

VAV_HUMAN
NC score	0.377540 (rank : 68)	θ value	8.97725e-08 (rank : 30)
Query Neighborhood Hits	479	Target Neighborhood Hits	452	Shared Neighborhood Hits	182
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_MOUSE
NC score	0.377017 (rank : 69)	θ value	1.29631e-06 (rank : 50)
Query Neighborhood Hits	479	Target Neighborhood Hits	456	Shared Neighborhood Hits	182
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

BCR_HUMAN
NC score	0.375376 (rank : 70)	θ value	1.80886e-08 (rank : 21)
Query Neighborhood Hits	479	Target Neighborhood Hits	204	Shared Neighborhood Hits	73
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

3BP1_HUMAN
NC score	0.373968 (rank : 71)	θ value	3.19293e-05 (rank : 82)
Query Neighborhood Hits	479	Target Neighborhood Hits	376	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

SLAP1_HUMAN
NC score	0.372595 (rank : 72)	θ value	0.00298849 (rank : 139)
Query Neighborhood Hits	479	Target Neighborhood Hits	113	Shared Neighborhood Hits	93
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

3BP1_MOUSE
NC score	0.368990 (rank : 73)	θ value	0.000786445 (rank : 124)
Query Neighborhood Hits	479	Target Neighborhood Hits	238	Shared Neighborhood Hits	71
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCGAP_HUMAN
NC score	0.368231 (rank : 74)	θ value	3.08544e-08 (rank : 24)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	123
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SOCS3_HUMAN
NC score	0.366975 (rank : 75)	θ value	0.000121331 (rank : 98)
Query Neighborhood Hits	479	Target Neighborhood Hits	77	Shared Neighborhood Hits	65
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

VAV_MOUSE
NC score	0.366288 (rank : 76)	θ value	3.41135e-07 (rank : 40)
Query Neighborhood Hits	479	Target Neighborhood Hits	430	Shared Neighborhood Hits	173
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

OPHN1_HUMAN
NC score	0.366182 (rank : 77)	θ value	6.43352e-06 (rank : 63)
Query Neighborhood Hits	479	Target Neighborhood Hits	161	Shared Neighborhood Hits	84
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG08_MOUSE
NC score	0.365595 (rank : 78)	θ value	1.29631e-06 (rank : 48)
Query Neighborhood Hits	479	Target Neighborhood Hits	73	Shared Neighborhood Hits	58
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

OPHN1_MOUSE
NC score	0.364619 (rank : 79)	θ value	6.43352e-06 (rank : 64)
Query Neighborhood Hits	479	Target Neighborhood Hits	174	Shared Neighborhood Hits	87
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

SOCS3_MOUSE
NC score	0.364301 (rank : 80)	θ value	0.000121331 (rank : 99)
Query Neighborhood Hits	479	Target Neighborhood Hits	72	Shared Neighborhood Hits	65
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

RHG08_HUMAN
NC score	0.362797 (rank : 81)	θ value	9.92553e-07 (rank : 46)
Query Neighborhood Hits	479	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

SOCS1_MOUSE
NC score	0.357507 (rank : 82)	θ value	0.00175202 (rank : 133)
Query Neighborhood Hits	479	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SHC3_MOUSE
NC score	0.351511 (rank : 83)	θ value	4.1701e-05 (rank : 86)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	107
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

RHG01_HUMAN
NC score	0.351444 (rank : 84)	θ value	0.000602161 (rank : 118)
Query Neighborhood Hits	479	Target Neighborhood Hits	75	Shared Neighborhood Hits	58
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG06_HUMAN
NC score	0.350449 (rank : 85)	θ value	0.000602161 (rank : 119)
Query Neighborhood Hits	479	Target Neighborhood Hits	114	Shared Neighborhood Hits	61
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SHC3_HUMAN
NC score	0.349281 (rank : 86)	θ value	2.44474e-05 (rank : 80)
Query Neighborhood Hits	479	Target Neighborhood Hits	155	Shared Neighborhood Hits	101
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

RHG06_MOUSE
NC score	0.346551 (rank : 87)	θ value	0.00175202 (rank : 132)
Query Neighborhood Hits	479	Target Neighborhood Hits	105	Shared Neighborhood Hits	59
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SHD_HUMAN
NC score	0.346097 (rank : 88)	θ value	0.00390308 (rank : 145)
Query Neighborhood Hits	479	Target Neighborhood Hits	204	Shared Neighborhood Hits	106
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SOCS1_HUMAN
NC score	0.344937 (rank : 89)	θ value	0.00509761 (rank : 150)
Query Neighborhood Hits	479	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

RASA1_HUMAN
NC score	0.337364 (rank : 90)	θ value	0.00175202 (rank : 131)
Query Neighborhood Hits	479	Target Neighborhood Hits	258	Shared Neighborhood Hits	129
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

TAGAP_HUMAN
NC score	0.333822 (rank : 91)	θ value	2.44474e-05 (rank : 81)
Query Neighborhood Hits	479	Target Neighborhood Hits	82	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.332496 (rank : 92)	θ value	0.00020696 (rank : 106)
Query Neighborhood Hits	479	Target Neighborhood Hits	83	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

CE005_HUMAN
NC score	0.323921 (rank : 93)	θ value	8.40245e-06 (rank : 67)
Query Neighborhood Hits	479	Target Neighborhood Hits	213	Shared Neighborhood Hits	114
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

RHG18_HUMAN
NC score	0.319128 (rank : 94)	θ value	0.00102713 (rank : 127)
Query Neighborhood Hits	479	Target Neighborhood Hits	90	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

CE005_MOUSE
NC score	0.318712 (rank : 95)	θ value	3.77169e-06 (rank : 59)
Query Neighborhood Hits	479	Target Neighborhood Hits	238	Shared Neighborhood Hits	99
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CEND2_HUMAN
NC score	0.316971 (rank : 96)	θ value	3.41135e-07 (rank : 37)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RHG18_MOUSE
NC score	0.313309 (rank : 97)	θ value	θ > 10 (rank : 1211)
Query Neighborhood Hits	479	Target Neighborhood Hits	110	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

SHC1_MOUSE
NC score	0.303459 (rank : 98)	θ value	0.000602161 (rank : 120)
Query Neighborhood Hits	479	Target Neighborhood Hits	180	Shared Neighborhood Hits	112
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

HSH2D_HUMAN
NC score	0.299228 (rank : 99)	θ value	1.06291 (rank : 308)
Query Neighborhood Hits	479	Target Neighborhood Hits	159	Shared Neighborhood Hits	112
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHC2_MOUSE
NC score	0.289027 (rank : 100)	θ value	0.000121331 (rank : 96)
Query Neighborhood Hits	479	Target Neighborhood Hits	144	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

HSH2D_MOUSE
NC score	0.288017 (rank : 101)	θ value	0.0563607 (rank : 193)
Query Neighborhood Hits	479	Target Neighborhood Hits	124	Shared Neighborhood Hits	91
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHC2_HUMAN
NC score	0.285629 (rank : 102)	θ value	0.000121331 (rank : 95)
Query Neighborhood Hits	479	Target Neighborhood Hits	170	Shared Neighborhood Hits	111
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

CEND3_MOUSE
NC score	0.281422 (rank : 103)	θ value	0.000270298 (rank : 108)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND1_MOUSE
NC score	0.274647 (rank : 104)	θ value	2.21117e-06 (rank : 51)
Query Neighborhood Hits	479	Target Neighborhood Hits	260	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

RHG07_MOUSE
NC score	0.274475 (rank : 105)	θ value	0.0193708 (rank : 173)
Query Neighborhood Hits	479	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CEND3_HUMAN
NC score	0.273397 (rank : 106)	θ value	0.00390308 (rank : 141)
Query Neighborhood Hits	479	Target Neighborhood Hits	275	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

RHG07_HUMAN
NC score	0.269657 (rank : 107)	θ value	0.0563607 (rank : 194)
Query Neighborhood Hits	479	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

SH24A_MOUSE
NC score	0.268854 (rank : 108)	θ value	0.0113563 (rank : 165)
Query Neighborhood Hits	479	Target Neighborhood Hits	326	Shared Neighborhood Hits	126
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SHC1_HUMAN
NC score	0.265734 (rank : 109)	θ value	θ > 10 (rank : 1270)
Query Neighborhood Hits	479	Target Neighborhood Hits	170	Shared Neighborhood Hits	110
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

PPIP1_HUMAN
NC score	0.265324 (rank : 110)	θ value	0.00228821 (rank : 138)
Query Neighborhood Hits	479	Target Neighborhood Hits	389	Shared Neighborhood Hits	185
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CEND1_HUMAN
NC score	0.264315 (rank : 111)	θ value	6.43352e-06 (rank : 62)
Query Neighborhood Hits	479	Target Neighborhood Hits	284	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SOCS5_HUMAN
NC score	0.263039 (rank : 112)	θ value	0.00509761 (rank : 151)
Query Neighborhood Hits	479	Target Neighborhood Hits	91	Shared Neighborhood Hits	72
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
NC score	0.262166 (rank : 113)	θ value	0.00509761 (rank : 152)
Query Neighborhood Hits	479	Target Neighborhood Hits	93	Shared Neighborhood Hits	71
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

STAR8_MOUSE
NC score	0.255984 (rank : 114)	θ value	0.0330416 (rank : 184)
Query Neighborhood Hits	479	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

MYO9B_MOUSE
NC score	0.254475 (rank : 115)	θ value	2.69671e-12 (rank : 10)
Query Neighborhood Hits	479	Target Neighborhood Hits	311	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SH24A_HUMAN
NC score	0.254235 (rank : 116)	θ value	0.279714 (rank : 246)
Query Neighborhood Hits	479	Target Neighborhood Hits	455	Shared Neighborhood Hits	183
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

STAR8_HUMAN
NC score	0.253519 (rank : 117)	θ value	0.0252991 (rank : 178)
Query Neighborhood Hits	479	Target Neighborhood Hits	216	Shared Neighborhood Hits	63
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

PPIP1_MOUSE
NC score	0.252816 (rank : 118)	θ value	0.00175202 (rank : 129)
Query Neighborhood Hits	479	Target Neighborhood Hits	377	Shared Neighborhood Hits	177
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

MYO9B_HUMAN
NC score	0.252558 (rank : 119)	θ value	1.2105e-12 (rank : 7)
Query Neighborhood Hits	479	Target Neighborhood Hits	641	Shared Neighborhood Hits	111
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SRBS1_HUMAN
NC score	0.250003 (rank : 120)	θ value	0.0252991 (rank : 177)
Query Neighborhood Hits	479	Target Neighborhood Hits	396	Shared Neighborhood Hits	127
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_MOUSE
NC score	0.249467 (rank : 121)	θ value	0.0330416 (rank : 187)
Query Neighborhood Hits	479	Target Neighborhood Hits	286	Shared Neighborhood Hits	117
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.248098 (rank : 122)	θ value	0.0330416 (rank : 186)
Query Neighborhood Hits	479	Target Neighborhood Hits	270	Shared Neighborhood Hits	118
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH22A_HUMAN
NC score	0.246124 (rank : 123)	θ value	0.62314 (rank : 283)
Query Neighborhood Hits	479	Target Neighborhood Hits	144	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SRBS1_MOUSE
NC score	0.243960 (rank : 124)	θ value	0.0563607 (rank : 197)
Query Neighborhood Hits	479	Target Neighborhood Hits	409	Shared Neighborhood Hits	126
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ITSN1_HUMAN
NC score	0.240920 (rank : 125)	θ value	1.87187e-05 (rank : 75)
Query Neighborhood Hits	479	Target Neighborhood Hits	1757	Shared Neighborhood Hits	330
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.238087 (rank : 126)	θ value	9.29e-05 (rank : 91)
Query Neighborhood Hits	479	Target Neighborhood Hits	1669	Shared Neighborhood Hits	318
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SOCS4_MOUSE
NC score	0.236141 (rank : 127)	θ value	0.0563607 (rank : 196)
Query Neighborhood Hits	479	Target Neighborhood Hits	69	Shared Neighborhood Hits	55
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

ITSN2_MOUSE
NC score	0.235898 (rank : 128)	θ value	0.21417 (rank : 233)
Query Neighborhood Hits	479	Target Neighborhood Hits	1371	Shared Neighborhood Hits	312
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SOCS4_HUMAN
NC score	0.235306 (rank : 129)	θ value	0.0563607 (rank : 195)
Query Neighborhood Hits	479	Target Neighborhood Hits	69	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

LCP2_MOUSE
NC score	0.234819 (rank : 130)	θ value	0.279714 (rank : 242)
Query Neighborhood Hits	479	Target Neighborhood Hits	177	Shared Neighborhood Hits	72
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SH21B_MOUSE
NC score	0.234219 (rank : 131)	θ value	θ > 10 (rank : 1260)
Query Neighborhood Hits	479	Target Neighborhood Hits	101	Shared Neighborhood Hits	80
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

STA13_HUMAN
NC score	0.229887 (rank : 132)	θ value	6.88961 (rank : 446)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

ITSN2_HUMAN
NC score	0.229233 (rank : 133)	θ value	0.365318 (rank : 256)
Query Neighborhood Hits	479	Target Neighborhood Hits	1173	Shared Neighborhood Hits	289
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

FGR_MOUSE
NC score	0.225684 (rank : 134)	θ value	2.44474e-05 (rank : 78)
Query Neighborhood Hits	479	Target Neighborhood Hits	1069	Shared Neighborhood Hits	193
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

STA13_MOUSE
NC score	0.223616 (rank : 135)	θ value	θ > 10 (rank : 1307)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	55
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

FGR_HUMAN
NC score	0.222287 (rank : 136)	θ value	1.87187e-05 (rank : 74)
Query Neighborhood Hits	479	Target Neighborhood Hits	1067	Shared Neighborhood Hits	190
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BLNK_MOUSE
NC score	0.219173 (rank : 137)	θ value	0.21417 (rank : 230)
Query Neighborhood Hits	479	Target Neighborhood Hits	296	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

NEBL_HUMAN
NC score	0.219127 (rank : 138)	θ value	0.00228821 (rank : 137)
Query Neighborhood Hits	479	Target Neighborhood Hits	457	Shared Neighborhood Hits	185
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SH21B_HUMAN
NC score	0.219030 (rank : 139)	θ value	θ > 10 (rank : 1259)
Query Neighborhood Hits	479	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

LNK_HUMAN
NC score	0.217785 (rank : 140)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

K1688_MOUSE
NC score	0.216979 (rank : 141)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	479	Target Neighborhood Hits	188	Shared Neighborhood Hits	61
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

LNK_MOUSE
NC score	0.214630 (rank : 142)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	479	Target Neighborhood Hits	132	Shared Neighborhood Hits	94
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

BLNK_HUMAN
NC score	0.214345 (rank : 143)	θ value	0.0330416 (rank : 180)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

FYN_MOUSE
NC score	0.213215 (rank : 144)	θ value	9.29e-05 (rank : 90)
Query Neighborhood Hits	479	Target Neighborhood Hits	1073	Shared Neighborhood Hits	186
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

APS_HUMAN
NC score	0.211752 (rank : 145)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	479	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

FYN_HUMAN
NC score	0.210855 (rank : 146)	θ value	0.000121331 (rank : 93)
Query Neighborhood Hits	479	Target Neighborhood Hits	1078	Shared Neighborhood Hits	190
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

BTK_HUMAN
NC score	0.210315 (rank : 147)	θ value	1.99992e-07 (rank : 34)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	167
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.209832 (rank : 148)	θ value	1.17247e-07 (rank : 31)
Query Neighborhood Hits	479	Target Neighborhood Hits	1017	Shared Neighborhood Hits	163
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SH21A_MOUSE
NC score	0.209796 (rank : 149)	θ value	θ > 10 (rank : 1258)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	69
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

K1688_HUMAN
NC score	0.209671 (rank : 150)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	479	Target Neighborhood Hits	217	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

SRC_HUMAN
NC score	0.209383 (rank : 151)	θ value	0.00175202 (rank : 134)
Query Neighborhood Hits	479	Target Neighborhood Hits	1058	Shared Neighborhood Hits	183
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_MOUSE
NC score	0.209211 (rank : 152)	θ value	0.000602161 (rank : 123)
Query Neighborhood Hits	479	Target Neighborhood Hits	1052	Shared Neighborhood Hits	173
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.208698 (rank : 153)	θ value	0.000602161 (rank : 122)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	172
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CD2AP_HUMAN
NC score	0.206535 (rank : 154)	θ value	0.62314 (rank : 276)
Query Neighborhood Hits	479	Target Neighborhood Hits	315	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ABL2_HUMAN
NC score	0.206197 (rank : 155)	θ value	4.45536e-07 (rank : 41)
Query Neighborhood Hits	479	Target Neighborhood Hits	1045	Shared Neighborhood Hits	160
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

PACN1_HUMAN
NC score	0.206191 (rank : 156)	θ value	0.0330416 (rank : 183)
Query Neighborhood Hits	479	Target Neighborhood Hits	320	Shared Neighborhood Hits	162
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH22A_MOUSE
NC score	0.205638 (rank : 157)	θ value	θ > 10 (rank : 1261)
Query Neighborhood Hits	479	Target Neighborhood Hits	179	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH21A_HUMAN
NC score	0.205144 (rank : 158)	θ value	θ > 10 (rank : 1257)
Query Neighborhood Hits	479	Target Neighborhood Hits	89	Shared Neighborhood Hits	69
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SRC_MOUSE
NC score	0.205084 (rank : 159)	θ value	0.00175202 (rank : 135)
Query Neighborhood Hits	479	Target Neighborhood Hits	1033	Shared Neighborhood Hits	179
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

PTN11_MOUSE
NC score	0.204862 (rank : 160)	θ value	0.00869519 (rank : 160)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	121
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.204845 (rank : 161)	θ value	0.00869519 (rank : 159)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	121
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

SH3K1_HUMAN
NC score	0.204005 (rank : 162)	θ value	0.00869519 (rank : 161)
Query Neighborhood Hits	479	Target Neighborhood Hits	341	Shared Neighborhood Hits	127
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

I5P2_HUMAN
NC score	0.203187 (rank : 163)	θ value	3.19293e-05 (rank : 85)
Query Neighborhood Hits	479	Target Neighborhood Hits	86	Shared Neighborhood Hits	50
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

PACN1_MOUSE
NC score	0.202224 (rank : 164)	θ value	0.0148317 (rank : 169)
Query Neighborhood Hits	479	Target Neighborhood Hits	283	Shared Neighborhood Hits	139
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABL1_HUMAN
NC score	0.201575 (rank : 165)	θ value	2.88788e-06 (rank : 55)
Query Neighborhood Hits	479	Target Neighborhood Hits	1220	Shared Neighborhood Hits	166
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.201117 (rank : 166)	θ value	2.88788e-06 (rank : 56)
Query Neighborhood Hits	479	Target Neighborhood Hits	1178	Shared Neighborhood Hits	166
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSK_HUMAN
NC score	0.200637 (rank : 167)	θ value	2.21117e-06 (rank : 52)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	171
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

FRK_HUMAN
NC score	0.200310 (rank : 168)	θ value	5.44631e-05 (rank : 87)
Query Neighborhood Hits	479	Target Neighborhood Hits	1058	Shared Neighborhood Hits	177
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

CSK_MOUSE
NC score	0.200260 (rank : 169)	θ value	3.77169e-06 (rank : 60)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	171
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

HCK_MOUSE
NC score	0.200117 (rank : 170)	θ value	0.000158464 (rank : 100)
Query Neighborhood Hits	479	Target Neighborhood Hits	1029	Shared Neighborhood Hits	168
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

OCRL_HUMAN
NC score	0.199835 (rank : 171)	θ value	0.00020696 (rank : 105)
Query Neighborhood Hits	479	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

CD2AP_MOUSE
NC score	0.199582 (rank : 172)	θ value	0.62314 (rank : 277)
Query Neighborhood Hits	479	Target Neighborhood Hits	336	Shared Neighborhood Hits	123
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

HCK_HUMAN
NC score	0.199091 (rank : 173)	θ value	3.19293e-05 (rank : 84)
Query Neighborhood Hits	479	Target Neighborhood Hits	1035	Shared Neighborhood Hits	172
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

DNMBP_HUMAN
NC score	0.198632 (rank : 174)	θ value	0.365318 (rank : 254)
Query Neighborhood Hits	479	Target Neighborhood Hits	413	Shared Neighborhood Hits	151
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRB14_MOUSE
NC score	0.197720 (rank : 175)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	479	Target Neighborhood Hits	149	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MATK_MOUSE
NC score	0.194388 (rank : 176)	θ value	5.81887e-07 (rank : 43)
Query Neighborhood Hits	479	Target Neighborhood Hits	952	Shared Neighborhood Hits	140
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PACN3_MOUSE
NC score	0.194285 (rank : 177)	θ value	0.365318 (rank : 259)
Query Neighborhood Hits	479	Target Neighborhood Hits	380	Shared Neighborhood Hits	158
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

MATK_HUMAN
NC score	0.193999 (rank : 178)	θ value	5.81887e-07 (rank : 42)
Query Neighborhood Hits	479	Target Neighborhood Hits	954	Shared Neighborhood Hits	139
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PACN2_HUMAN
NC score	0.193249 (rank : 179)	θ value	1.06291 (rank : 312)
Query Neighborhood Hits	479	Target Neighborhood Hits	339	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NPHP1_MOUSE
NC score	0.192842 (rank : 180)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	479	Target Neighborhood Hits	267	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PACN3_HUMAN
NC score	0.192779 (rank : 181)	θ value	0.279714 (rank : 243)
Query Neighborhood Hits	479	Target Neighborhood Hits	385	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

GRB14_HUMAN
NC score	0.191935 (rank : 182)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	479	Target Neighborhood Hits	137	Shared Neighborhood Hits	96
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

TEC_HUMAN
NC score	0.191870 (rank : 183)	θ value	8.40245e-06 (rank : 68)
Query Neighborhood Hits	479	Target Neighborhood Hits	1006	Shared Neighborhood Hits	155
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.191396 (rank : 184)	θ value	1.29631e-06 (rank : 49)
Query Neighborhood Hits	479	Target Neighborhood Hits	971	Shared Neighborhood Hits	155
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

PACN2_MOUSE
NC score	0.191370 (rank : 185)	θ value	1.06291 (rank : 313)
Query Neighborhood Hits	479	Target Neighborhood Hits	382	Shared Neighborhood Hits	164
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

FER_HUMAN
NC score	0.190840 (rank : 186)	θ value	2.44474e-05 (rank : 77)
Query Neighborhood Hits	479	Target Neighborhood Hits	1278	Shared Neighborhood Hits	259
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SH3K1_MOUSE
NC score	0.190612 (rank : 187)	θ value	1.38821 (rank : 324)
Query Neighborhood Hits	479	Target Neighborhood Hits	332	Shared Neighborhood Hits	128
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

DNMBP_MOUSE
NC score	0.190456 (rank : 188)	θ value	0.47712 (rank : 264)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	142
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LYN_MOUSE
NC score	0.189890 (rank : 189)	θ value	0.000270298 (rank : 110)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	163
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

GRB7_MOUSE
NC score	0.189760 (rank : 190)	θ value	8.99809 (rank : 458)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

TXK_MOUSE
NC score	0.188621 (rank : 191)	θ value	0.00020696 (rank : 107)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	168
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LYN_HUMAN
NC score	0.188201 (rank : 192)	θ value	0.000602161 (rank : 116)
Query Neighborhood Hits	479	Target Neighborhood Hits	1022	Shared Neighborhood Hits	163
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LCK_HUMAN
NC score	0.187746 (rank : 193)	θ value	0.00509761 (rank : 147)
Query Neighborhood Hits	479	Target Neighborhood Hits	987	Shared Neighborhood Hits	147
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LASP1_HUMAN
NC score	0.187548 (rank : 194)	θ value	0.00869519 (rank : 157)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	102
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

TEC_MOUSE
NC score	0.187433 (rank : 195)	θ value	1.87187e-05 (rank : 76)
Query Neighborhood Hits	479	Target Neighborhood Hits	1006	Shared Neighborhood Hits	152
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LASP1_MOUSE
NC score	0.185850 (rank : 196)	θ value	0.00869519 (rank : 158)
Query Neighborhood Hits	479	Target Neighborhood Hits	297	Shared Neighborhood Hits	100
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LCP2_HUMAN
NC score	0.185811 (rank : 197)	θ value	0.163984 (rank : 221)
Query Neighborhood Hits	479	Target Neighborhood Hits	531	Shared Neighborhood Hits	81
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCK_MOUSE
NC score	0.184985 (rank : 198)	θ value	0.0113563 (rank : 164)
Query Neighborhood Hits	479	Target Neighborhood Hits	981	Shared Neighborhood Hits	149
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PTK6_MOUSE
NC score	0.184961 (rank : 199)	θ value	3.77169e-06 (rank : 61)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	159
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

BLK_MOUSE
NC score	0.184668 (rank : 200)	θ value	0.21417 (rank : 229)
Query Neighborhood Hits	479	Target Neighborhood Hits	992	Shared Neighborhood Hits	162
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PTN6_MOUSE
NC score	0.184495 (rank : 201)	θ value	0.00175202 (rank : 130)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	118
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

ITK_HUMAN
NC score	0.184470 (rank : 202)	θ value	0.00035302 (rank : 112)
Query Neighborhood Hits	479	Target Neighborhood Hits	1016	Shared Neighborhood Hits	150
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

CIP4_HUMAN
NC score	0.184332 (rank : 203)	θ value	0.62314 (rank : 278)
Query Neighborhood Hits	479	Target Neighborhood Hits	374	Shared Neighborhood Hits	145
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

NCF2_HUMAN
NC score	0.181895 (rank : 204)	θ value	5.27518 (rank : 423)
Query Neighborhood Hits	479	Target Neighborhood Hits	229	Shared Neighborhood Hits	102
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

BLK_HUMAN
NC score	0.181575 (rank : 205)	θ value	0.163984 (rank : 217)
Query Neighborhood Hits	479	Target Neighborhood Hits	994	Shared Neighborhood Hits	158
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ITK_MOUSE
NC score	0.181018 (rank : 206)	θ value	0.000602161 (rank : 115)
Query Neighborhood Hits	479	Target Neighborhood Hits	985	Shared Neighborhood Hits	142
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

PTK6_HUMAN
NC score	0.180971 (rank : 207)	θ value	9.92553e-07 (rank : 45)
Query Neighborhood Hits	479	Target Neighborhood Hits	1020	Shared Neighborhood Hits	158
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BMX_HUMAN
NC score	0.180802 (rank : 208)	θ value	1.29631e-06 (rank : 47)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	114
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BCAR3_HUMAN
NC score	0.180662 (rank : 209)	θ value	0.813845 (rank : 288)
Query Neighborhood Hits	479	Target Neighborhood Hits	129	Shared Neighborhood Hits	81
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BMX_MOUSE
NC score	0.178766 (rank : 210)	θ value	8.40245e-06 (rank : 66)
Query Neighborhood Hits	479	Target Neighborhood Hits	912	Shared Neighborhood Hits	110
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BCAR3_MOUSE
NC score	0.177886 (rank : 211)	θ value	0.365318 (rank : 253)
Query Neighborhood Hits	479	Target Neighborhood Hits	127	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ABI2_MOUSE
NC score	0.177239 (rank : 212)	θ value	0.365318 (rank : 250)
Query Neighborhood Hits	479	Target Neighborhood Hits	266	Shared Neighborhood Hits	103
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NPHP1_HUMAN
NC score	0.177098 (rank : 213)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	479	Target Neighborhood Hits	288	Shared Neighborhood Hits	126
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ABI2_HUMAN
NC score	0.175883 (rank : 214)	θ value	0.365318 (rank : 249)
Query Neighborhood Hits	479	Target Neighborhood Hits	350	Shared Neighborhood Hits	105
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

STAC_MOUSE
NC score	0.173002 (rank : 215)	θ value	θ > 10 (rank : 1311)
Query Neighborhood Hits	479	Target Neighborhood Hits	268	Shared Neighborhood Hits	112
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB7_HUMAN
NC score	0.172703 (rank : 216)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	479	Target Neighborhood Hits	156	Shared Neighborhood Hits	98
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PTN6_HUMAN
NC score	0.171310 (rank : 217)	θ value	0.163984 (rank : 223)
Query Neighborhood Hits	479	Target Neighborhood Hits	234	Shared Neighborhood Hits	114
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SRMS_HUMAN
NC score	0.170906 (rank : 218)	θ value	θ > 10 (rank : 1305)
Query Neighborhood Hits	479	Target Neighborhood Hits	946	Shared Neighborhood Hits	134
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

APS_MOUSE
NC score	0.168739 (rank : 219)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	479	Target Neighborhood Hits	134	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

HMMR_MOUSE
NC score	0.167530 (rank : 220)	θ value	0.0330416 (rank : 181)
Query Neighborhood Hits	479	Target Neighborhood Hits	1178	Shared Neighborhood Hits	240
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

STAC_HUMAN
NC score	0.167395 (rank : 221)	θ value	θ > 10 (rank : 1310)
Query Neighborhood Hits	479	Target Neighborhood Hits	276	Shared Neighborhood Hits	114
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

KSYK_MOUSE
NC score	0.166772 (rank : 222)	θ value	0.000158464 (rank : 101)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	119
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.166404 (rank : 223)	θ value	0.000121331 (rank : 94)
Query Neighborhood Hits	479	Target Neighborhood Hits	901	Shared Neighborhood Hits	117
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SRMS_MOUSE
NC score	0.165364 (rank : 224)	θ value	θ > 10 (rank : 1306)
Query Neighborhood Hits	479	Target Neighborhood Hits	964	Shared Neighborhood Hits	152
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC3_HUMAN
NC score	0.164500 (rank : 225)	θ value	θ > 10 (rank : 1308)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	103
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.164177 (rank : 226)	θ value	θ > 10 (rank : 1309)
Query Neighborhood Hits	479	Target Neighborhood Hits	232	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DESP_HUMAN
NC score	0.163004 (rank : 227)	θ value	3.19293e-05 (rank : 83)
Query Neighborhood Hits	479	Target Neighborhood Hits	1470	Shared Neighborhood Hits	247
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

HCLS1_MOUSE
NC score	0.162662 (rank : 228)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	479	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CI093_HUMAN
NC score	0.162511 (rank : 229)	θ value	0.0563607 (rank : 191)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	241
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

SH2D3_MOUSE
NC score	0.162248 (rank : 230)	θ value	θ > 10 (rank : 1264)
Query Neighborhood Hits	479	Target Neighborhood Hits	174	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

ARHG7_MOUSE
NC score	0.161920 (rank : 231)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	479	Target Neighborhood Hits	396	Shared Neighborhood Hits	156
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ABI1_MOUSE
NC score	0.161849 (rank : 232)	θ value	1.81305 (rank : 331)
Query Neighborhood Hits	479	Target Neighborhood Hits	246	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

IF3A_MOUSE
NC score	0.160914 (rank : 233)	θ value	0.813845 (rank : 294)
Query Neighborhood Hits	479	Target Neighborhood Hits	871	Shared Neighborhood Hits	201
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IF3A_HUMAN
NC score	0.160768 (rank : 234)	θ value	1.06291 (rank : 309)
Query Neighborhood Hits	479	Target Neighborhood Hits	875	Shared Neighborhood Hits	200
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

CI039_HUMAN
NC score	0.160139 (rank : 235)	θ value	0.0736092 (rank : 199)
Query Neighborhood Hits	479	Target Neighborhood Hits	1171	Shared Neighborhood Hits	220
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

INCE_MOUSE
NC score	0.159657 (rank : 236)	θ value	0.0736092 (rank : 201)
Query Neighborhood Hits	479	Target Neighborhood Hits	903	Shared Neighborhood Hits	188
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

DZIP1_MOUSE
NC score	0.159592 (rank : 237)	θ value	0.125558 (rank : 214)
Query Neighborhood Hits	479	Target Neighborhood Hits	530	Shared Neighborhood Hits	124
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

TENS4_MOUSE
NC score	0.158956 (rank : 238)	θ value	1.81305 (rank : 349)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

SH2D3_HUMAN
NC score	0.158638 (rank : 239)	θ value	θ > 10 (rank : 1263)
Query Neighborhood Hits	479	Target Neighborhood Hits	188	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

DZIP1_HUMAN
NC score	0.157782 (rank : 240)	θ value	0.163984 (rank : 218)
Query Neighborhood Hits	479	Target Neighborhood Hits	675	Shared Neighborhood Hits	118
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

CN145_MOUSE
NC score	0.157635 (rank : 241)	θ value	0.0736092 (rank : 200)
Query Neighborhood Hits	479	Target Neighborhood Hits	916	Shared Neighborhood Hits	212
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

SH23A_HUMAN
NC score	0.157318 (rank : 242)	θ value	θ > 10 (rank : 1262)
Query Neighborhood Hits	479	Target Neighborhood Hits	149	Shared Neighborhood Hits	79
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

HCLS1_HUMAN
NC score	0.157296 (rank : 243)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	479	Target Neighborhood Hits	358	Shared Neighborhood Hits	104
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

STAM1_HUMAN
NC score	0.156985 (rank : 244)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	479	Target Neighborhood Hits	271	Shared Neighborhood Hits	106
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.156032 (rank : 245)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	479	Target Neighborhood Hits	285	Shared Neighborhood Hits	110
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SRC8_HUMAN
NC score	0.155773 (rank : 246)	θ value	θ > 10 (rank : 1303)
Query Neighborhood Hits	479	Target Neighborhood Hits	269	Shared Neighborhood Hits	114
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CN145_HUMAN
NC score	0.155730 (rank : 247)	θ value	0.0961366 (rank : 206)
Query Neighborhood Hits	479	Target Neighborhood Hits	1196	Shared Neighborhood Hits	241
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

STAM1_MOUSE
NC score	0.155695 (rank : 248)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	479	Target Neighborhood Hits	273	Shared Neighborhood Hits	103
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
NC score	0.155618 (rank : 249)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	479	Target Neighborhood Hits	288	Shared Neighborhood Hits	115
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ZAP70_MOUSE
NC score	0.155420 (rank : 250)	θ value	0.0252991 (rank : 179)
Query Neighborhood Hits	479	Target Neighborhood Hits	905	Shared Neighborhood Hits	119
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

AHI1_HUMAN
NC score	0.155240 (rank : 251)	θ value	0.21417 (rank : 227)
Query Neighborhood Hits	479	Target Neighborhood Hits	537	Shared Neighborhood Hits	123
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

GOGB1_HUMAN
NC score	0.154986 (rank : 252)	θ value	0.163984 (rank : 220)
Query Neighborhood Hits	479	Target Neighborhood Hits	2297	Shared Neighborhood Hits	279
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

AKAP9_HUMAN
NC score	0.154984 (rank : 253)	θ value	0.365318 (rank : 252)
Query Neighborhood Hits	479	Target Neighborhood Hits	1710	Shared Neighborhood Hits	251
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ARHG7_HUMAN
NC score	0.154587 (rank : 254)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	479	Target Neighborhood Hits	347	Shared Neighborhood Hits	130
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ERC2_MOUSE
NC score	0.153833 (rank : 255)	θ value	0.21417 (rank : 232)
Query Neighborhood Hits	479	Target Neighborhood Hits	1166	Shared Neighborhood Hits	230
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

GOGA4_HUMAN
NC score	0.153778 (rank : 256)	θ value	0.813845 (rank : 292)
Query Neighborhood Hits	479	Target Neighborhood Hits	2034	Shared Neighborhood Hits	268
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ARHG6_HUMAN
NC score	0.153534 (rank : 257)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	479	Target Neighborhood Hits	376	Shared Neighborhood Hits	145
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ERC2_HUMAN
NC score	0.153492 (rank : 258)	θ value	0.21417 (rank : 231)
Query Neighborhood Hits	479	Target Neighborhood Hits	1156	Shared Neighborhood Hits	229
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

GOGA4_MOUSE
NC score	0.153050 (rank : 259)	θ value	0.0563607 (rank : 192)
Query Neighborhood Hits	479	Target Neighborhood Hits	1939	Shared Neighborhood Hits	258
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ZAP70_HUMAN
NC score	0.152988 (rank : 260)	θ value	0.0330416 (rank : 188)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	117
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SRC8_MOUSE
NC score	0.152876 (rank : 261)	θ value	θ > 10 (rank : 1304)
Query Neighborhood Hits	479	Target Neighborhood Hits	292	Shared Neighborhood Hits	114
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ABI1_HUMAN
NC score	0.152844 (rank : 262)	θ value	3.0926 (rank : 373)
Query Neighborhood Hits	479	Target Neighborhood Hits	257	Shared Neighborhood Hits	99
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CP135_MOUSE
NC score	0.152516 (rank : 263)	θ value	0.000786445 (rank : 125)
Query Neighborhood Hits	479	Target Neighborhood Hits	1278	Shared Neighborhood Hits	241
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

KMHN1_HUMAN
NC score	0.152503 (rank : 264)	θ value	0.00390308 (rank : 144)
Query Neighborhood Hits	479	Target Neighborhood Hits	950	Shared Neighborhood Hits	213
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

SM1L2_MOUSE
NC score	0.152481 (rank : 265)	θ value	0.00509761 (rank : 149)
Query Neighborhood Hits	479	Target Neighborhood Hits	918	Shared Neighborhood Hits	221
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

AHI1_MOUSE
NC score	0.151866 (rank : 266)	θ value	0.125558 (rank : 210)
Query Neighborhood Hits	479	Target Neighborhood Hits	496	Shared Neighborhood Hits	110
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG6_MOUSE
NC score	0.151753 (rank : 267)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	479	Target Neighborhood Hits	394	Shared Neighborhood Hits	162
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

BICD1_MOUSE
NC score	0.151731 (rank : 268)	θ value	0.0961366 (rank : 204)
Query Neighborhood Hits	479	Target Neighborhood Hits	837	Shared Neighborhood Hits	212
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

DBNL_HUMAN
NC score	0.150699 (rank : 269)	θ value	1.06291 (rank : 306)
Query Neighborhood Hits	479	Target Neighborhood Hits	244	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

TRHY_HUMAN
NC score	0.150545 (rank : 270)	θ value	0.47712 (rank : 273)
Query Neighborhood Hits	479	Target Neighborhood Hits	1385	Shared Neighborhood Hits	239
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

CENPF_HUMAN
NC score	0.150512 (rank : 271)	θ value	0.0961366 (rank : 205)
Query Neighborhood Hits	479	Target Neighborhood Hits	1932	Shared Neighborhood Hits	270
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CP135_HUMAN
NC score	0.150206 (rank : 272)	θ value	0.125558 (rank : 212)
Query Neighborhood Hits	479	Target Neighborhood Hits	1290	Shared Neighborhood Hits	240
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CK5P2_HUMAN
NC score	0.150038 (rank : 273)	θ value	0.0193708 (rank : 171)
Query Neighborhood Hits	479	Target Neighborhood Hits	1433	Shared Neighborhood Hits	242
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

SMC3_MOUSE
NC score	0.149736 (rank : 274)	θ value	1.38821 (rank : 326)
Query Neighborhood Hits	479	Target Neighborhood Hits	1187	Shared Neighborhood Hits	224
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.149440 (rank : 275)	θ value	1.38821 (rank : 325)
Query Neighborhood Hits	479	Target Neighborhood Hits	1186	Shared Neighborhood Hits	224
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

CE290_HUMAN
NC score	0.148946 (rank : 276)	θ value	1.06291 (rank : 303)
Query Neighborhood Hits	479	Target Neighborhood Hits	1553	Shared Neighborhood Hits	247
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

GRB10_HUMAN
NC score	0.148360 (rank : 277)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	479	Target Neighborhood Hits	147	Shared Neighborhood Hits	93
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

SPTA1_MOUSE
NC score	0.148234 (rank : 278)	θ value	0.0736092 (rank : 203)
Query Neighborhood Hits	479	Target Neighborhood Hits	675	Shared Neighborhood Hits	246
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TEX9_HUMAN
NC score	0.147976 (rank : 279)	θ value	0.21417 (rank : 235)
Query Neighborhood Hits	479	Target Neighborhood Hits	541	Shared Neighborhood Hits	169
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

CK5P2_MOUSE
NC score	0.146915 (rank : 280)	θ value	0.47712 (rank : 263)
Query Neighborhood Hits	479	Target Neighborhood Hits	1151	Shared Neighborhood Hits	223
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

RB6I2_HUMAN
NC score	0.146737 (rank : 281)	θ value	0.279714 (rank : 245)
Query Neighborhood Hits	479	Target Neighborhood Hits	1584	Shared Neighborhood Hits	244
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

TENS4_HUMAN
NC score	0.146660 (rank : 282)	θ value	3.0926 (rank : 392)
Query Neighborhood Hits	479	Target Neighborhood Hits	214	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

SPTA2_HUMAN
NC score	0.146624 (rank : 283)	θ value	θ > 10 (rank : 1297)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	263
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SAS6_MOUSE
NC score	0.146443 (rank : 284)	θ value	0.47712 (rank : 269)
Query Neighborhood Hits	479	Target Neighborhood Hits	931	Shared Neighborhood Hits	208
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

OSTF1_HUMAN
NC score	0.145771 (rank : 285)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	479	Target Neighborhood Hits	466	Shared Neighborhood Hits	111
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

HOOK3_HUMAN
NC score	0.145697 (rank : 286)	θ value	0.00869519 (rank : 156)
Query Neighborhood Hits	479	Target Neighborhood Hits	1070	Shared Neighborhood Hits	234
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

NEBU_HUMAN
NC score	0.145255 (rank : 287)	θ value	0.813845 (rank : 297)
Query Neighborhood Hits	479	Target Neighborhood Hits	420	Shared Neighborhood Hits	148
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SM1L2_HUMAN
NC score	0.145121 (rank : 288)	θ value	0.125558 (rank : 216)
Query Neighborhood Hits	479	Target Neighborhood Hits	1019	Shared Neighborhood Hits	219
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

TACC2_HUMAN
NC score	0.144949 (rank : 289)	θ value	0.0148317 (rank : 170)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	178
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

GRB10_MOUSE
NC score	0.144921 (rank : 290)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	479	Target Neighborhood Hits	156	Shared Neighborhood Hits	94
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

SH3G2_HUMAN
NC score	0.144914 (rank : 291)	θ value	θ > 10 (rank : 1266)
Query Neighborhood Hits	479	Target Neighborhood Hits	324	Shared Neighborhood Hits	143
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

NCF1_MOUSE
NC score	0.144548 (rank : 292)	θ value	θ > 10 (rank : 1093)
Query Neighborhood Hits	479	Target Neighborhood Hits	198	Shared Neighborhood Hits	92
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

RB6I2_MOUSE
NC score	0.144540 (rank : 293)	θ value	0.47712 (rank : 267)
Query Neighborhood Hits	479	Target Neighborhood Hits	1433	Shared Neighborhood Hits	234
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RAD50_MOUSE
NC score	0.144380 (rank : 294)	θ value	0.0193708 (rank : 172)
Query Neighborhood Hits	479	Target Neighborhood Hits	1366	Shared Neighborhood Hits	235
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

SH3G1_HUMAN
NC score	0.143926 (rank : 295)	θ value	3.0926 (rank : 388)
Query Neighborhood Hits	479	Target Neighborhood Hits	307	Shared Neighborhood Hits	140
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

GCC2_HUMAN
NC score	0.143789 (rank : 296)	θ value	0.163984 (rank : 219)
Query Neighborhood Hits	479	Target Neighborhood Hits	1558	Shared Neighborhood Hits	252
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

DBNL_MOUSE
NC score	0.143637 (rank : 297)	θ value	1.81305 (rank : 338)
Query Neighborhood Hits	479	Target Neighborhood Hits	306	Shared Neighborhood Hits	110
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

HOOK3_MOUSE
NC score	0.143482 (rank : 298)	θ value	0.0113563 (rank : 163)
Query Neighborhood Hits	479	Target Neighborhood Hits	1007	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

RBP24_HUMAN
NC score	0.143408 (rank : 299)	θ value	0.163984 (rank : 224)
Query Neighborhood Hits	479	Target Neighborhood Hits	1559	Shared Neighborhood Hits	254
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

HMMR_HUMAN
NC score	0.142898 (rank : 300)	θ value	2.36792 (rank : 358)
Query Neighborhood Hits	479	Target Neighborhood Hits	1082	Shared Neighborhood Hits	220
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

NCF1_HUMAN
NC score	0.142895 (rank : 301)	θ value	θ > 10 (rank : 1092)
Query Neighborhood Hits	479	Target Neighborhood Hits	198	Shared Neighborhood Hits	87
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

BICD1_HUMAN
NC score	0.142164 (rank : 302)	θ value	0.47712 (rank : 262)
Query Neighborhood Hits	479	Target Neighborhood Hits	844	Shared Neighborhood Hits	212
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

SH3G3_MOUSE
NC score	0.141799 (rank : 303)	θ value	6.88961 (rank : 445)
Query Neighborhood Hits	479	Target Neighborhood Hits	236	Shared Neighborhood Hits	112
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

CING_HUMAN
NC score	0.140156 (rank : 304)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	479	Target Neighborhood Hits	1275	Shared Neighborhood Hits	232
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

GOGA6_HUMAN
NC score	0.140080 (rank : 305)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	479	Target Neighborhood Hits	1007	Shared Neighborhood Hits	220
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

TACC3_HUMAN
NC score	0.139575 (rank : 306)	θ value	1.38821 (rank : 330)
Query Neighborhood Hits	479	Target Neighborhood Hits	779	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

CJ118_HUMAN
NC score	0.138774 (rank : 307)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	479	Target Neighborhood Hits	937	Shared Neighborhood Hits	213
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

K0555_HUMAN
NC score	0.138515 (rank : 308)	θ value	0.62314 (rank : 281)
Query Neighborhood Hits	479	Target Neighborhood Hits	880	Shared Neighborhood Hits	198
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

OSTF1_MOUSE
NC score	0.138209 (rank : 309)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	479	Target Neighborhood Hits	467	Shared Neighborhood Hits	112
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SPTA1_HUMAN
NC score	0.138068 (rank : 310)	θ value	θ > 10 (rank : 1296)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	259
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SYCP1_HUMAN
NC score	0.137612 (rank : 311)	θ value	1.38821 (rank : 329)
Query Neighborhood Hits	479	Target Neighborhood Hits	1313	Shared Neighborhood Hits	239
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TACC2_MOUSE
NC score	0.137470 (rank : 312)	θ value	0.365318 (rank : 260)
Query Neighborhood Hits	479	Target Neighborhood Hits	774	Shared Neighborhood Hits	165
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

EEA1_HUMAN
NC score	0.136975 (rank : 313)	θ value	4.03905 (rank : 398)
Query Neighborhood Hits	479	Target Neighborhood Hits	1796	Shared Neighborhood Hits	260
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ZN291_HUMAN
NC score	0.136647 (rank : 314)	θ value	0.62314 (rank : 287)
Query Neighborhood Hits	479	Target Neighborhood Hits	647	Shared Neighborhood Hits	174
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

ABI3_HUMAN
NC score	0.136382 (rank : 315)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PIBF1_HUMAN
NC score	0.136131 (rank : 316)	θ value	0.279714 (rank : 244)
Query Neighborhood Hits	479	Target Neighborhood Hits	1041	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

FES_HUMAN
NC score	0.135916 (rank : 317)	θ value	2.36792 (rank : 355)
Query Neighborhood Hits	479	Target Neighborhood Hits	978	Shared Neighborhood Hits	135
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

NUMA1_HUMAN
NC score	0.135474 (rank : 318)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	479	Target Neighborhood Hits	1523	Shared Neighborhood Hits	246
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

MYH3_HUMAN
NC score	0.135355 (rank : 319)	θ value	0.00228821 (rank : 136)
Query Neighborhood Hits	479	Target Neighborhood Hits	1660	Shared Neighborhood Hits	258
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

ABI3_MOUSE
NC score	0.135130 (rank : 320)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G2_MOUSE
NC score	0.135093 (rank : 321)	θ value	θ > 10 (rank : 1267)
Query Neighborhood Hits	479	Target Neighborhood Hits	319	Shared Neighborhood Hits	135
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

TPR_HUMAN
NC score	0.134856 (rank : 322)	θ value	0.47712 (rank : 272)
Query Neighborhood Hits	479	Target Neighborhood Hits	1921	Shared Neighborhood Hits	254
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

SH3G1_MOUSE
NC score	0.134832 (rank : 323)	θ value	θ > 10 (rank : 1265)
Query Neighborhood Hits	479	Target Neighborhood Hits	291	Shared Neighborhood Hits	139
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SMC1A_HUMAN
NC score	0.134758 (rank : 324)	θ value	θ > 10 (rank : 1279)
Query Neighborhood Hits	479	Target Neighborhood Hits	1346	Shared Neighborhood Hits	236
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

OFD1_HUMAN
NC score	0.134724 (rank : 325)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	188
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

TRIPB_HUMAN
NC score	0.134517 (rank : 326)	θ value	4.03905 (rank : 410)
Query Neighborhood Hits	479	Target Neighborhood Hits	1587	Shared Neighborhood Hits	258
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

GOGA1_HUMAN
NC score	0.134487 (rank : 327)	θ value	1.38821 (rank : 321)
Query Neighborhood Hits	479	Target Neighborhood Hits	1222	Shared Neighborhood Hits	237
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

XE7_HUMAN
NC score	0.134380 (rank : 328)	θ value	4.03905 (rank : 412)
Query Neighborhood Hits	479	Target Neighborhood Hits	738	Shared Neighborhood Hits	178
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

SMC2_MOUSE
NC score	0.134128 (rank : 329)	θ value	θ > 10 (rank : 1281)
Query Neighborhood Hits	479	Target Neighborhood Hits	1131	Shared Neighborhood Hits	226
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

GOGA1_MOUSE
NC score	0.133627 (rank : 330)	θ value	0.279714 (rank : 239)
Query Neighborhood Hits	479	Target Neighborhood Hits	994	Shared Neighborhood Hits	223
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

INCE_HUMAN
NC score	0.133586 (rank : 331)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	479	Target Neighborhood Hits	978	Shared Neighborhood Hits	201
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

MY18A_HUMAN
NC score	0.133576 (rank : 332)	θ value	3.0926 (rank : 385)
Query Neighborhood Hits	479	Target Neighborhood Hits	1929	Shared Neighborhood Hits	270
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

BPAEA_MOUSE
NC score	0.133541 (rank : 333)	θ value	0.62314 (rank : 274)
Query Neighborhood Hits	479	Target Neighborhood Hits	1480	Shared Neighborhood Hits	243
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CP250_HUMAN
NC score	0.133534 (rank : 334)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	479	Target Neighborhood Hits	1805	Shared Neighborhood Hits	255
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CP250_MOUSE
NC score	0.133459 (rank : 335)	θ value	4.03905 (rank : 396)
Query Neighborhood Hits	479	Target Neighborhood Hits	1583	Shared Neighborhood Hits	241
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

RBCC1_MOUSE
NC score	0.133336 (rank : 336)	θ value	5.27518 (rank : 425)
Query Neighborhood Hits	479	Target Neighborhood Hits	1048	Shared Neighborhood Hits	221
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

CCD39_MOUSE
NC score	0.132930 (rank : 337)	θ value	1.38821 (rank : 319)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	219
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

SMC1A_MOUSE
NC score	0.132857 (rank : 338)	θ value	θ > 10 (rank : 1280)
Query Neighborhood Hits	479	Target Neighborhood Hits	1384	Shared Neighborhood Hits	240
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

TNIP3_HUMAN
NC score	0.132695 (rank : 339)	θ value	θ > 10 (rank : 1381)
Query Neighborhood Hits	479	Target Neighborhood Hits	511	Shared Neighborhood Hits	163
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

GRAP1_HUMAN
NC score	0.132548 (rank : 340)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	208
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

CCD46_HUMAN
NC score	0.132321 (rank : 341)	θ value	3.0926 (rank : 376)
Query Neighborhood Hits	479	Target Neighborhood Hits	1430	Shared Neighborhood Hits	249
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

GOGA3_MOUSE
NC score	0.132262 (rank : 342)	θ value	8.99809 (rank : 457)
Query Neighborhood Hits	479	Target Neighborhood Hits	1437	Shared Neighborhood Hits	235
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

CJ118_MOUSE
NC score	0.132185 (rank : 343)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	479	Target Neighborhood Hits	1132	Shared Neighborhood Hits	218
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

GCC2_MOUSE
NC score	0.132125 (rank : 344)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	479	Target Neighborhood Hits	1619	Shared Neighborhood Hits	251
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

HOOK1_MOUSE
NC score	0.131991 (rank : 345)	θ value	4.03905 (rank : 400)
Query Neighborhood Hits	479	Target Neighborhood Hits	910	Shared Neighborhood Hits	217
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

MYH11_MOUSE
NC score	0.131975 (rank : 346)	θ value	0.813845 (rank : 296)
Query Neighborhood Hits	479	Target Neighborhood Hits	1777	Shared Neighborhood Hits	257
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

GRAP1_MOUSE
NC score	0.131970 (rank : 347)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	479	Target Neighborhood Hits	1234	Shared Neighborhood Hits	224
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

CENPE_HUMAN
NC score	0.131919 (rank : 348)	θ value	0.0736092 (rank : 198)
Query Neighborhood Hits	479	Target Neighborhood Hits	2060	Shared Neighborhood Hits	270
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CASP_HUMAN
NC score	0.131912 (rank : 349)	θ value	1.81305 (rank : 332)
Query Neighborhood Hits	479	Target Neighborhood Hits	1131	Shared Neighborhood Hits	220
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

SH3G3_HUMAN
NC score	0.131738 (rank : 350)	θ value	θ > 10 (rank : 1268)
Query Neighborhood Hits	479	Target Neighborhood Hits	222	Shared Neighborhood Hits	109
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

AZI1_MOUSE
NC score	0.131701 (rank : 351)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	479	Target Neighborhood Hits	990	Shared Neighborhood Hits	213
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

RAD50_HUMAN
NC score	0.131487 (rank : 352)	θ value	θ > 10 (rank : 1195)
Query Neighborhood Hits	479	Target Neighborhood Hits	1317	Shared Neighborhood Hits	241
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RIMB1_MOUSE
NC score	0.131456 (rank : 353)	θ value	θ > 10 (rank : 1214)
Query Neighborhood Hits	479	Target Neighborhood Hits	1376	Shared Neighborhood Hits	271
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNX18_MOUSE
NC score	0.131435 (rank : 354)	θ value	0.0431538 (rank : 189)
Query Neighborhood Hits	479	Target Neighborhood Hits	198	Shared Neighborhood Hits	77
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SMC2_HUMAN
NC score	0.131212 (rank : 355)	θ value	0.813845 (rank : 299)
Query Neighborhood Hits	479	Target Neighborhood Hits	1405	Shared Neighborhood Hits	233
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

BICD2_HUMAN
NC score	0.131147 (rank : 356)	θ value	0.279714 (rank : 237)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	198
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

MYH13_HUMAN
NC score	0.131140 (rank : 357)	θ value	0.0961366 (rank : 208)
Query Neighborhood Hits	479	Target Neighborhood Hits	1504	Shared Neighborhood Hits	248
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PEX13_HUMAN
NC score	0.131113 (rank : 358)	θ value	1.06291 (rank : 314)
Query Neighborhood Hits	479	Target Neighborhood Hits	128	Shared Neighborhood Hits	70
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SYCP1_MOUSE
NC score	0.130879 (rank : 359)	θ value	θ > 10 (rank : 1338)
Query Neighborhood Hits	479	Target Neighborhood Hits	1456	Shared Neighborhood Hits	238
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

IFT74_MOUSE
NC score	0.130410 (rank : 360)	θ value	1.81305 (rank : 339)
Query Neighborhood Hits	479	Target Neighborhood Hits	939	Shared Neighborhood Hits	224
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

TEX9_MOUSE
NC score	0.130393 (rank : 361)	θ value	8.99809 (rank : 476)
Query Neighborhood Hits	479	Target Neighborhood Hits	581	Shared Neighborhood Hits	173
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

CR034_MOUSE
NC score	0.130376 (rank : 362)	θ value	0.125558 (rank : 213)
Query Neighborhood Hits	479	Target Neighborhood Hits	643	Shared Neighborhood Hits	191
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

MY18A_MOUSE
NC score	0.130337 (rank : 363)	θ value	8.99809 (rank : 466)
Query Neighborhood Hits	479	Target Neighborhood Hits	1989	Shared Neighborhood Hits	266
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH8_HUMAN
NC score	0.130071 (rank : 364)	θ value	0.0330416 (rank : 182)
Query Neighborhood Hits	479	Target Neighborhood Hits	1610	Shared Neighborhood Hits	259
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

TAXB1_HUMAN
NC score	0.129930 (rank : 365)	θ value	θ > 10 (rank : 1351)
Query Neighborhood Hits	479	Target Neighborhood Hits	829	Shared Neighborhood Hits	199
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

PHLB2_MOUSE
NC score	0.129853 (rank : 366)	θ value	0.00102713 (rank : 126)
Query Neighborhood Hits	479	Target Neighborhood Hits	1016	Shared Neighborhood Hits	205
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

MYH1_MOUSE
NC score	0.129641 (rank : 367)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	479	Target Neighborhood Hits	1461	Shared Neighborhood Hits	248
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH9_HUMAN
NC score	0.129563 (rank : 368)	θ value	8.99809 (rank : 468)
Query Neighborhood Hits	479	Target Neighborhood Hits	1762	Shared Neighborhood Hits	260
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

FES_MOUSE
NC score	0.129525 (rank : 369)	θ value	3.0926 (rank : 379)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	138
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SNX18_HUMAN
NC score	0.129461 (rank : 370)	θ value	0.0961366 (rank : 209)
Query Neighborhood Hits	479	Target Neighborhood Hits	207	Shared Neighborhood Hits	80
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

AZI1_HUMAN
NC score	0.129340 (rank : 371)	θ value	3.0926 (rank : 374)
Query Neighborhood Hits	479	Target Neighborhood Hits	1000	Shared Neighborhood Hits	209
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

TUFT1_MOUSE
NC score	0.129284 (rank : 372)	θ value	0.00665767 (rank : 154)
Query Neighborhood Hits	479	Target Neighborhood Hits	732	Shared Neighborhood Hits	184
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

REST_HUMAN
NC score	0.129199 (rank : 373)	θ value	0.62314 (rank : 282)
Query Neighborhood Hits	479	Target Neighborhood Hits	1605	Shared Neighborhood Hits	236
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

CING_MOUSE
NC score	0.129112 (rank : 374)	θ value	1.81305 (rank : 335)
Query Neighborhood Hits	479	Target Neighborhood Hits	1432	Shared Neighborhood Hits	242
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

RIMB1_HUMAN
NC score	0.129097 (rank : 375)	θ value	θ > 10 (rank : 1213)
Query Neighborhood Hits	479	Target Neighborhood Hits	1479	Shared Neighborhood Hits	264
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MYH4_MOUSE
NC score	0.129071 (rank : 376)	θ value	6.88961 (rank : 439)
Query Neighborhood Hits	479	Target Neighborhood Hits	1476	Shared Neighborhood Hits	248
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH9_MOUSE
NC score	0.128216 (rank : 377)	θ value	6.88961 (rank : 440)
Query Neighborhood Hits	479	Target Neighborhood Hits	1829	Shared Neighborhood Hits	256
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH11_HUMAN
NC score	0.128203 (rank : 378)	θ value	5.27518 (rank : 422)
Query Neighborhood Hits	479	Target Neighborhood Hits	1806	Shared Neighborhood Hits	257
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

REST_MOUSE
NC score	0.128141 (rank : 379)	θ value	6.88961 (rank : 444)
Query Neighborhood Hits	479	Target Neighborhood Hits	1506	Shared Neighborhood Hits	242
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

MYH10_HUMAN
NC score	0.127727 (rank : 380)	θ value	0.365318 (rank : 257)
Query Neighborhood Hits	479	Target Neighborhood Hits	1620	Shared Neighborhood Hits	249
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RBCC1_HUMAN
NC score	0.127616 (rank : 381)	θ value	θ > 10 (rank : 1203)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	214
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

CE152_HUMAN
NC score	0.127513 (rank : 382)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	479	Target Neighborhood Hits	976	Shared Neighborhood Hits	207
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

FLIP1_MOUSE
NC score	0.127467 (rank : 383)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	479	Target Neighborhood Hits	1176	Shared Neighborhood Hits	212
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_HUMAN
NC score	0.127429 (rank : 384)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	479	Target Neighborhood Hits	1405	Shared Neighborhood Hits	237
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

MYH8_MOUSE
NC score	0.127308 (rank : 385)	θ value	θ > 10 (rank : 1068)
Query Neighborhood Hits	479	Target Neighborhood Hits	1600	Shared Neighborhood Hits	254
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

CCD46_MOUSE
NC score	0.127270 (rank : 386)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	479	Target Neighborhood Hits	1405	Shared Neighborhood Hits	248
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

MYH4_HUMAN
NC score	0.127075 (rank : 387)	θ value	θ > 10 (rank : 1065)
Query Neighborhood Hits	479	Target Neighborhood Hits	1377	Shared Neighborhood Hits	246
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

CEP63_HUMAN
NC score	0.127057 (rank : 388)	θ value	2.36792 (rank : 353)
Query Neighborhood Hits	479	Target Neighborhood Hits	1005	Shared Neighborhood Hits	213
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

EEA1_MOUSE
NC score	0.126825 (rank : 389)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	479	Target Neighborhood Hits	1637	Shared Neighborhood Hits	241
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYH10_MOUSE
NC score	0.126677 (rank : 390)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	479	Target Neighborhood Hits	1612	Shared Neighborhood Hits	246
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

EVPL_HUMAN
NC score	0.126496 (rank : 391)	θ value	0.62314 (rank : 280)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	209
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

IFT74_HUMAN
NC score	0.126394 (rank : 392)	θ value	8.99809 (rank : 459)
Query Neighborhood Hits	479	Target Neighborhood Hits	949	Shared Neighborhood Hits	209
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

CEP55_MOUSE
NC score	0.126029 (rank : 393)	θ value	5.27518 (rank : 417)
Query Neighborhood Hits	479	Target Neighborhood Hits	693	Shared Neighborhood Hits	193
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

GOGA2_MOUSE
NC score	0.125960 (rank : 394)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	214
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

CCD39_HUMAN
NC score	0.125772 (rank : 395)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	479	Target Neighborhood Hits	868	Shared Neighborhood Hits	208
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

NCF4_MOUSE
NC score	0.125509 (rank : 396)	θ value	θ > 10 (rank : 1095)
Query Neighborhood Hits	479	Target Neighborhood Hits	177	Shared Neighborhood Hits	84
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CASP_MOUSE
NC score	0.125469 (rank : 397)	θ value	0.813845 (rank : 289)
Query Neighborhood Hits	479	Target Neighborhood Hits	1152	Shared Neighborhood Hits	224
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

MYH1_HUMAN
NC score	0.125339 (rank : 398)	θ value	6.88961 (rank : 438)
Query Neighborhood Hits	479	Target Neighborhood Hits	1478	Shared Neighborhood Hits	251
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

RABE1_HUMAN
NC score	0.125288 (rank : 399)	θ value	θ > 10 (rank : 1191)
Query Neighborhood Hits	479	Target Neighborhood Hits	1104	Shared Neighborhood Hits	224
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

PEPL_HUMAN
NC score	0.125282 (rank : 400)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	479	Target Neighborhood Hits	1141	Shared Neighborhood Hits	223
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

KTN1_HUMAN
NC score	0.125279 (rank : 401)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	479	Target Neighborhood Hits	1197	Shared Neighborhood Hits	227
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

BICD2_MOUSE
NC score	0.125052 (rank : 402)	θ value	0.279714 (rank : 238)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	198
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CTGE5_MOUSE
NC score	0.124776 (rank : 403)	θ value	4.03905 (rank : 397)
Query Neighborhood Hits	479	Target Neighborhood Hits	928	Shared Neighborhood Hits	213
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

CCD41_MOUSE
NC score	0.124720 (rank : 404)	θ value	8.99809 (rank : 453)
Query Neighborhood Hits	479	Target Neighborhood Hits	1399	Shared Neighborhood Hits	232
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

TMF1_HUMAN
NC score	0.124700 (rank : 405)	θ value	θ > 10 (rank : 1377)
Query Neighborhood Hits	479	Target Neighborhood Hits	987	Shared Neighborhood Hits	216
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

CKAP4_MOUSE
NC score	0.124687 (rank : 406)	θ value	1.06291 (rank : 304)
Query Neighborhood Hits	479	Target Neighborhood Hits	596	Shared Neighborhood Hits	165
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

SAS6_HUMAN
NC score	0.124579 (rank : 407)	θ value	θ > 10 (rank : 1249)
Query Neighborhood Hits	479	Target Neighborhood Hits	791	Shared Neighborhood Hits	194
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

HOOK1_HUMAN
NC score	0.124453 (rank : 408)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	217
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

NAF1_MOUSE
NC score	0.124412 (rank : 409)	θ value	0.365318 (rank : 258)
Query Neighborhood Hits	479	Target Neighborhood Hits	852	Shared Neighborhood Hits	184
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

RFIP3_HUMAN
NC score	0.124030 (rank : 410)	θ value	1.81305 (rank : 346)
Query Neighborhood Hits	479	Target Neighborhood Hits	1055	Shared Neighborhood Hits	206
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

KTN1_MOUSE
NC score	0.123902 (rank : 411)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	479	Target Neighborhood Hits	1324	Shared Neighborhood Hits	221
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

PCNT_HUMAN
NC score	0.123589 (rank : 412)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	479	Target Neighborhood Hits	1551	Shared Neighborhood Hits	245
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

CCD19_HUMAN
NC score	0.123532 (rank : 413)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	479	Target Neighborhood Hits	639	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CUTL1_MOUSE
NC score	0.123474 (rank : 414)	θ value	0.813845 (rank : 290)
Query Neighborhood Hits	479	Target Neighborhood Hits	1620	Shared Neighborhood Hits	226
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CCHCR_MOUSE
NC score	0.123402 (rank : 415)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	479	Target Neighborhood Hits	932	Shared Neighborhood Hits	191
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CYTSA_HUMAN
NC score	0.123190 (rank : 416)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	479	Target Neighborhood Hits	1138	Shared Neighborhood Hits	224
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

MYH2_HUMAN
NC score	0.122877 (rank : 417)	θ value	8.99809 (rank : 467)
Query Neighborhood Hits	479	Target Neighborhood Hits	1491	Shared Neighborhood Hits	247
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

CALD1_HUMAN
NC score	0.122487 (rank : 418)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	197
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

KMHN1_MOUSE
NC score	0.122483 (rank : 419)	θ value	6.88961 (rank : 436)
Query Neighborhood Hits	479	Target Neighborhood Hits	949	Shared Neighborhood Hits	206
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

CR034_HUMAN
NC score	0.122437 (rank : 420)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	479	Target Neighborhood Hits	538	Shared Neighborhood Hits	179
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

ADIP_HUMAN
NC score	0.122361 (rank : 421)	θ value	0.365318 (rank : 251)
Query Neighborhood Hits	479	Target Neighborhood Hits	470	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

CROCC_HUMAN
NC score	0.122326 (rank : 422)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	479	Target Neighborhood Hits	1409	Shared Neighborhood Hits	234
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

SPN90_HUMAN
NC score	0.122223 (rank : 423)	θ value	θ > 10 (rank : 1294)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

RABE1_MOUSE
NC score	0.121899 (rank : 424)	θ value	θ > 10 (rank : 1192)
Query Neighborhood Hits	479	Target Neighborhood Hits	1105	Shared Neighborhood Hits	226
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

ARHG4_HUMAN
NC score	0.121673 (rank : 425)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	479	Target Neighborhood Hits	242	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FYCO1_MOUSE
NC score	0.121512 (rank : 426)	θ value	3.0926 (rank : 380)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	210
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

CYTSA_MOUSE
NC score	0.121296 (rank : 427)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	479	Target Neighborhood Hits	1104	Shared Neighborhood Hits	222
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

NIN_HUMAN
NC score	0.121091 (rank : 428)	θ value	5.27518 (rank : 424)
Query Neighborhood Hits	479	Target Neighborhood Hits	1416	Shared Neighborhood Hits	232
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

MYH7_HUMAN
NC score	0.120947 (rank : 429)	θ value	1.81305 (rank : 344)
Query Neighborhood Hits	479	Target Neighborhood Hits	1559	Shared Neighborhood Hits	249
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

TAXB1_MOUSE
NC score	0.120624 (rank : 430)	θ value	1.81305 (rank : 348)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	205
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

PEX13_MOUSE
NC score	0.120606 (rank : 431)	θ value	6.88961 (rank : 443)
Query Neighborhood Hits	479	Target Neighborhood Hits	126	Shared Neighborhood Hits	75
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CCD11_HUMAN
NC score	0.120564 (rank : 432)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	479	Target Neighborhood Hits	822	Shared Neighborhood Hits	190
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

NAF1_HUMAN
NC score	0.120472 (rank : 433)	θ value	1.06291 (rank : 311)
Query Neighborhood Hits	479	Target Neighborhood Hits	937	Shared Neighborhood Hits	192
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

C102B_HUMAN
NC score	0.120311 (rank : 434)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	479	Target Neighborhood Hits	542	Shared Neighborhood Hits	179
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

MYH6_HUMAN
NC score	0.120185 (rank : 435)	θ value	θ > 10 (rank : 1066)
Query Neighborhood Hits	479	Target Neighborhood Hits	1426	Shared Neighborhood Hits	244
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SMC4_HUMAN
NC score	0.119811 (rank : 436)	θ value	8.99809 (rank : 472)
Query Neighborhood Hits	479	Target Neighborhood Hits	937	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

GAS8_MOUSE
NC score	0.119543 (rank : 437)	θ value	3.0926 (rank : 381)
Query Neighborhood Hits	479	Target Neighborhood Hits	622	Shared Neighborhood Hits	182
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

CTRO_MOUSE
NC score	0.119534 (rank : 438)	θ value	0.0113563 (rank : 162)
Query Neighborhood Hits	479	Target Neighborhood Hits	2344	Shared Neighborhood Hits	295
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CCHCR_HUMAN
NC score	0.119466 (rank : 439)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	479	Target Neighborhood Hits	717	Shared Neighborhood Hits	176
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CF060_HUMAN
NC score	0.119372 (rank : 440)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	479	Target Neighborhood Hits	1270	Shared Neighborhood Hits	227
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

FYCO1_HUMAN
NC score	0.119330 (rank : 441)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	479	Target Neighborhood Hits	1149	Shared Neighborhood Hits	215
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

GOGA3_HUMAN
NC score	0.119326 (rank : 442)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	479	Target Neighborhood Hits	1317	Shared Neighborhood Hits	229
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

CAF1A_MOUSE
NC score	0.119273 (rank : 443)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	479	Target Neighborhood Hits	736	Shared Neighborhood Hits	172
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

MYH6_MOUSE
NC score	0.119114 (rank : 444)	θ value	θ > 10 (rank : 1067)
Query Neighborhood Hits	479	Target Neighborhood Hits	1501	Shared Neighborhood Hits	244
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PLCB1_MOUSE
NC score	0.118744 (rank : 445)	θ value	0.163984 (rank : 222)
Query Neighborhood Hits	479	Target Neighborhood Hits	531	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

MD1L1_MOUSE
NC score	0.118728 (rank : 446)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	479	Target Neighborhood Hits	1001	Shared Neighborhood Hits	215
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

EVPL_MOUSE
NC score	0.118708 (rank : 447)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	479	Target Neighborhood Hits	952	Shared Neighborhood Hits	214
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

PEPL_MOUSE
NC score	0.118663 (rank : 448)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	479	Target Neighborhood Hits	1105	Shared Neighborhood Hits	227
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

UACA_MOUSE
NC score	0.118627 (rank : 449)	θ value	0.279714 (rank : 248)
Query Neighborhood Hits	479	Target Neighborhood Hits	1620	Shared Neighborhood Hits	239
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

RASF8_HUMAN
NC score	0.118557 (rank : 450)	θ value	θ > 10 (rank : 1200)
Query Neighborhood Hits	479	Target Neighborhood Hits	469	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

NIN_MOUSE
NC score	0.118321 (rank : 451)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	479	Target Neighborhood Hits	1376	Shared Neighborhood Hits	233
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

CUTL1_HUMAN
NC score	0.117715 (rank : 452)	θ value	1.81305 (rank : 337)
Query Neighborhood Hits	479	Target Neighborhood Hits	1574	Shared Neighborhood Hits	217
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CROCC_MOUSE
NC score	0.117504 (rank : 453)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	479	Target Neighborhood Hits	1460	Shared Neighborhood Hits	231
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CTRO_HUMAN
NC score	0.117365 (rank : 454)	θ value	0.00869519 (rank : 155)
Query Neighborhood Hits	479	Target Neighborhood Hits	2092	Shared Neighborhood Hits	283
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CCD62_HUMAN
NC score	0.117353 (rank : 455)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	479	Target Neighborhood Hits	631	Shared Neighborhood Hits	185
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

3BP2_MOUSE
NC score	0.117296 (rank : 456)	θ value	0.279714 (rank : 236)
Query Neighborhood Hits	479	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SWP70_HUMAN
NC score	0.117212 (rank : 457)	θ value	θ > 10 (rank : 1336)
Query Neighborhood Hits	479	Target Neighborhood Hits	973	Shared Neighborhood Hits	211
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MD1L1_HUMAN
NC score	0.117140 (rank : 458)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	210
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MYO1F_MOUSE
NC score	0.117134 (rank : 459)	θ value	θ > 10 (rank : 1082)
Query Neighborhood Hits	479	Target Neighborhood Hits	262	Shared Neighborhood Hits	123
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

CTGE5_HUMAN
NC score	0.117067 (rank : 460)	θ value	1.06291 (rank : 305)
Query Neighborhood Hits	479	Target Neighborhood Hits	800	Shared Neighborhood Hits	210
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

GOGA5_HUMAN
NC score	0.116904 (rank : 461)	θ value	1.06291 (rank : 307)
Query Neighborhood Hits	479	Target Neighborhood Hits	1168	Shared Neighborhood Hits	212
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

CT2NL_HUMAN
NC score	0.116889 (rank : 462)	θ value	0.62314 (rank : 279)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	204
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

SWP70_MOUSE
NC score	0.116561 (rank : 463)	θ value	θ > 10 (rank : 1337)
Query Neighborhood Hits	479	Target Neighborhood Hits	1097	Shared Neighborhood Hits	217
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MYO1F_HUMAN
NC score	0.116306 (rank : 464)	θ value	θ > 10 (rank : 1081)
Query Neighborhood Hits	479	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

LRRF2_HUMAN
NC score	0.115882 (rank : 465)	θ value	4.03905 (rank : 403)
Query Neighborhood Hits	479	Target Neighborhood Hits	791	Shared Neighborhood Hits	192
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

BRE1A_MOUSE
NC score	0.115805 (rank : 466)	θ value	5.27518 (rank : 415)
Query Neighborhood Hits	479	Target Neighborhood Hits	1025	Shared Neighborhood Hits	212
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

LUZP1_HUMAN
NC score	0.115285 (rank : 467)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	479	Target Neighborhood Hits	739	Shared Neighborhood Hits	192
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

EP15R_MOUSE
NC score	0.115221 (rank : 468)	θ value	5.27518 (rank : 419)
Query Neighborhood Hits	479	Target Neighborhood Hits	1135	Shared Neighborhood Hits	206
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

MYH14_MOUSE
NC score	0.115210 (rank : 469)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	479	Target Neighborhood Hits	1225	Shared Neighborhood Hits	230
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

TXLNG_MOUSE
NC score	0.115174 (rank : 470)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	479	Target Neighborhood Hits	552	Shared Neighborhood Hits	175
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

HOOK2_MOUSE
NC score	0.115143 (rank : 471)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	479	Target Neighborhood Hits	736	Shared Neighborhood Hits	188
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

CYLN2_MOUSE
NC score	0.114844 (rank : 472)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	479	Target Neighborhood Hits	1002	Shared Neighborhood Hits	212
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

EP15_HUMAN
NC score	0.114786 (rank : 473)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	479	Target Neighborhood Hits	1021	Shared Neighborhood Hits	218
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

LRC45_HUMAN
NC score	0.114694 (rank : 474)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	479	Target Neighborhood Hits	933	Shared Neighborhood Hits	200
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

GAS8_HUMAN
NC score	0.114514 (rank : 475)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	479	Target Neighborhood Hits	819	Shared Neighborhood Hits	190
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

M3KL4_HUMAN
NC score	0.114409 (rank : 476)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	479	Target Neighborhood Hits	1087	Shared Neighborhood Hits	171
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CCD41_HUMAN
NC score	0.114352 (rank : 477)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	479	Target Neighborhood Hits	1139	Shared Neighborhood Hits	206
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

IFT81_HUMAN
NC score	0.114117 (rank : 478)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	200
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CAR11_HUMAN
NC score	0.113851 (rank : 479)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	479	Target Neighborhood Hits	690	Shared Neighborhood Hits	186
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

MRCKA_HUMAN
NC score	0.113839 (rank : 480)	θ value	1.38821 (rank : 322)
Query Neighborhood Hits	479	Target Neighborhood Hits	1999	Shared Neighborhood Hits	288
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

GOGA2_HUMAN
NC score	0.113664 (rank : 481)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	192
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

SMC4_MOUSE
NC score	0.113615 (rank : 482)	θ value	θ > 10 (rank : 1282)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	201
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

RUFY2_HUMAN
NC score	0.113543 (rank : 483)	θ value	0.163984 (rank : 225)
Query Neighborhood Hits	479	Target Neighborhood Hits	1208	Shared Neighborhood Hits	215
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

CEP55_HUMAN
NC score	0.113272 (rank : 484)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	479	Target Neighborhood Hits	504	Shared Neighborhood Hits	163
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

MRCKB_MOUSE
NC score	0.113212 (rank : 485)	θ value	0.0961366 (rank : 207)
Query Neighborhood Hits	479	Target Neighborhood Hits	2180	Shared Neighborhood Hits	295
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PCNT_MOUSE
NC score	0.113118 (rank : 486)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	479	Target Neighborhood Hits	1207	Shared Neighborhood Hits	216
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

CCD13_HUMAN
NC score	0.112885 (rank : 487)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	479	Target Neighborhood Hits	721	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

EFS_MOUSE
NC score	0.112824 (rank : 488)	θ value	4.03905 (rank : 399)
Query Neighborhood Hits	479	Target Neighborhood Hits	389	Shared Neighborhood Hits	95
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MYO5C_HUMAN
NC score	0.112716 (rank : 489)	θ value	θ > 10 (rank : 1089)
Query Neighborhood Hits	479	Target Neighborhood Hits	1206	Shared Neighborhood Hits	228
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

GOGA5_MOUSE
NC score	0.112517 (rank : 490)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	479	Target Neighborhood Hits	1434	Shared Neighborhood Hits	235
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

UACA_HUMAN
NC score	0.112393 (rank : 491)	θ value	0.365318 (rank : 261)
Query Neighborhood Hits	479	Target Neighborhood Hits	1622	Shared Neighborhood Hits	236
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

IFT81_MOUSE
NC score	0.112336 (rank : 492)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	191
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

PHLB2_HUMAN
NC score	0.112280 (rank : 493)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	479	Target Neighborhood Hits	964	Shared Neighborhood Hits	204
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

MYO1E_HUMAN
NC score	0.112099 (rank : 494)	θ value	θ > 10 (rank : 1080)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	119
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PLEC1_HUMAN
NC score	0.111950 (rank : 495)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	479	Target Neighborhood Hits	1326	Shared Neighborhood Hits	230
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

OPTN_MOUSE
NC score	0.111941 (rank : 496)	θ value	8.99809 (rank : 470)
Query Neighborhood Hits	479	Target Neighborhood Hits	1120	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

LUZP1_MOUSE
NC score	0.111817 (rank : 497)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	479	Target Neighborhood Hits	940	Shared Neighborhood Hits	203
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

SDCG8_MOUSE
NC score	0.111439 (rank : 498)	θ value	θ > 10 (rank : 1253)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	204
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SPN90_MOUSE
NC score	0.111317 (rank : 499)	θ value	θ > 10 (rank : 1295)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

CARD9_HUMAN
NC score	0.111063 (rank : 500)	θ value	3.0926 (rank : 375)
Query Neighborhood Hits	479	Target Neighborhood Hits	602	Shared Neighborhood Hits	172
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

ADIP_MOUSE
NC score	0.111009 (rank : 501)	θ value	1.06291 (rank : 302)
Query Neighborhood Hits	479	Target Neighborhood Hits	415	Shared Neighborhood Hits	139
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

SDCG8_HUMAN
NC score	0.110995 (rank : 502)	θ value	θ > 10 (rank : 1252)
Query Neighborhood Hits	479	Target Neighborhood Hits	1002	Shared Neighborhood Hits	198
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

POF1B_MOUSE
NC score	0.110956 (rank : 503)	θ value	1.06291 (rank : 315)
Query Neighborhood Hits	479	Target Neighborhood Hits	530	Shared Neighborhood Hits	168
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

TEX14_MOUSE
NC score	0.110887 (rank : 504)	θ value	θ > 10 (rank : 1362)
Query Neighborhood Hits	479	Target Neighborhood Hits	1333	Shared Neighborhood Hits	159
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ACK1_MOUSE
NC score	0.110881 (rank : 505)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	479	Target Neighborhood Hits	1080	Shared Neighborhood Hits	87
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

CAR14_HUMAN
NC score	0.110867 (rank : 506)	θ value	4.03905 (rank : 394)
Query Neighborhood Hits	479	Target Neighborhood Hits	449	Shared Neighborhood Hits	147
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CCD11_MOUSE
NC score	0.110653 (rank : 507)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	479	Target Neighborhood Hits	498	Shared Neighborhood Hits	152
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD21_HUMAN
NC score	0.110603 (rank : 508)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	479	Target Neighborhood Hits	1228	Shared Neighborhood Hits	218
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CYLN2_HUMAN
NC score	0.110537 (rank : 509)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	479	Target Neighborhood Hits	1004	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CCDC6_HUMAN
NC score	0.110441 (rank : 510)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	479	Target Neighborhood Hits	723	Shared Neighborhood Hits	178
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

STYK1_HUMAN
NC score	0.110426 (rank : 511)	θ value	θ > 10 (rank : 1333)
Query Neighborhood Hits	479	Target Neighborhood Hits	786	Shared Neighborhood Hits	58
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

CTGE6_HUMAN
NC score	0.110379 (rank : 512)	θ value	3.0926 (rank : 377)
Query Neighborhood Hits	479	Target Neighborhood Hits	650	Shared Neighborhood Hits	183
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

ES8L3_HUMAN
NC score	0.110134 (rank : 513)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	479	Target Neighborhood Hits	206	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ACK1_HUMAN
NC score	0.110109 (rank : 514)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	479	Target Neighborhood Hits	1140	Shared Neighborhood Hits	88
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

BPA1_MOUSE
NC score	0.110019 (rank : 515)	θ value	0.0148317 (rank : 166)
Query Neighborhood Hits	479	Target Neighborhood Hits	1477	Shared Neighborhood Hits	228
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MY18B_HUMAN
NC score	0.109989 (rank : 516)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	479	Target Neighborhood Hits	1299	Shared Neighborhood Hits	209
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

TXLNG_HUMAN
NC score	0.109984 (rank : 517)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	479	Target Neighborhood Hits	568	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

HOME2_MOUSE
NC score	0.109926 (rank : 518)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	479	Target Neighborhood Hits	882	Shared Neighborhood Hits	193
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

M3K11_HUMAN
NC score	0.109911 (rank : 519)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	479	Target Neighborhood Hits	1136	Shared Neighborhood Hits	139
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RADI_HUMAN
NC score	0.109906 (rank : 520)	θ value	1.06291 (rank : 316)
Query Neighborhood Hits	479	Target Neighborhood Hits	741	Shared Neighborhood Hits	187
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

STYK1_MOUSE
NC score	0.109791 (rank : 521)	θ value	θ > 10 (rank : 1334)
Query Neighborhood Hits	479	Target Neighborhood Hits	779	Shared Neighborhood Hits	58
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CT2NL_MOUSE
NC score	0.109767 (rank : 522)	θ value	1.38821 (rank : 320)
Query Neighborhood Hits	479	Target Neighborhood Hits	902	Shared Neighborhood Hits	183
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

PLCB1_HUMAN
NC score	0.109704 (rank : 523)	θ value	1.81305 (rank : 345)
Query Neighborhood Hits	479	Target Neighborhood Hits	614	Shared Neighborhood Hits	170
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

TACC3_MOUSE
NC score	0.109632 (rank : 524)	θ value	0.813845 (rank : 300)
Query Neighborhood Hits	479	Target Neighborhood Hits	607	Shared Neighborhood Hits	157
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

BRE1A_HUMAN
NC score	0.109561 (rank : 525)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	479	Target Neighborhood Hits	1071	Shared Neighborhood Hits	213
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

CCD21_MOUSE
NC score	0.109450 (rank : 526)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	479	Target Neighborhood Hits	1135	Shared Neighborhood Hits	211
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

MYH14_HUMAN
NC score	0.109396 (rank : 527)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	479	Target Neighborhood Hits	995	Shared Neighborhood Hits	211
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

M3K9_HUMAN
NC score	0.109117 (rank : 528)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	479	Target Neighborhood Hits	1123	Shared Neighborhood Hits	163
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ROCK1_MOUSE
NC score	0.109065 (rank : 529)	θ value	2.36792 (rank : 371)
Query Neighborhood Hits	479	Target Neighborhood Hits	2126	Shared Neighborhood Hits	288
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CCD91_HUMAN
NC score	0.108988 (rank : 530)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	479	Target Neighborhood Hits	868	Shared Neighborhood Hits	193
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

MRCKB_HUMAN
NC score	0.108533 (rank : 531)	θ value	3.0926 (rank : 384)
Query Neighborhood Hits	479	Target Neighborhood Hits	2239	Shared Neighborhood Hits	290
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TPM2_HUMAN
NC score	0.108476 (rank : 532)	θ value	θ > 10 (rank : 1391)
Query Neighborhood Hits	479	Target Neighborhood Hits	677	Shared Neighborhood Hits	189
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

NUF2_MOUSE
NC score	0.108361 (rank : 533)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	479	Target Neighborhood Hits	585	Shared Neighborhood Hits	168
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

LTK_HUMAN
NC score	0.108291 (rank : 534)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	479	Target Neighborhood Hits	774	Shared Neighborhood Hits	58
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

BI2L1_MOUSE
NC score	0.108200 (rank : 535)	θ value	0.00509761 (rank : 146)
Query Neighborhood Hits	479	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

LTK_MOUSE
NC score	0.108178 (rank : 536)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	479	Target Neighborhood Hits	770	Shared Neighborhood Hits	60
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.107935 (rank : 537)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	479	Target Neighborhood Hits	811	Shared Neighborhood Hits	60
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

MOES_HUMAN
NC score	0.107761 (rank : 538)	θ value	5.27518 (rank : 421)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	211
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

HAP1_HUMAN
NC score	0.107629 (rank : 539)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	479	Target Neighborhood Hits	606	Shared Neighborhood Hits	158
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

MYO10_HUMAN
NC score	0.107548 (rank : 540)	θ value	θ > 10 (rank : 1070)
Query Neighborhood Hits	479	Target Neighborhood Hits	920	Shared Neighborhood Hits	202
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

RYK_HUMAN
NC score	0.107423 (rank : 541)	θ value	θ > 10 (rank : 1245)
Query Neighborhood Hits	479	Target Neighborhood Hits	701	Shared Neighborhood Hits	51
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

CAF1A_HUMAN
NC score	0.107370 (rank : 542)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	479	Target Neighborhood Hits	750	Shared Neighborhood Hits	165
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

ANR26_MOUSE
NC score	0.107298 (rank : 543)	θ value	1.38821 (rank : 318)
Query Neighborhood Hits	479	Target Neighborhood Hits	1554	Shared Neighborhood Hits	232
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ALK_HUMAN
NC score	0.107226 (rank : 544)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	479	Target Neighborhood Hits	795	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

KINH_HUMAN
NC score	0.107167 (rank : 545)	θ value	0.279714 (rank : 241)
Query Neighborhood Hits	479	Target Neighborhood Hits	1231	Shared Neighborhood Hits	233
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

POF1B_HUMAN
NC score	0.107156 (rank : 546)	θ value	1.38821 (rank : 323)
Query Neighborhood Hits	479	Target Neighborhood Hits	494	Shared Neighborhood Hits	160
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

CKAP4_HUMAN
NC score	0.107080 (rank : 547)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	479	Target Neighborhood Hits	592	Shared Neighborhood Hits	162
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

TACC1_HUMAN
NC score	0.107037 (rank : 548)	θ value	θ > 10 (rank : 1342)
Query Neighborhood Hits	479	Target Neighborhood Hits	597	Shared Neighborhood Hits	159
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

MYO5A_HUMAN
NC score	0.106964 (rank : 549)	θ value	θ > 10 (rank : 1086)
Query Neighborhood Hits	479	Target Neighborhood Hits	1092	Shared Neighborhood Hits	208
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

INVO_HUMAN
NC score	0.106912 (rank : 550)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	479	Target Neighborhood Hits	636	Shared Neighborhood Hits	153
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

CCD91_MOUSE
NC score	0.106780 (rank : 551)	θ value	5.27518 (rank : 416)
Query Neighborhood Hits	479	Target Neighborhood Hits	699	Shared Neighborhood Hits	171
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

GCC1_MOUSE
NC score	0.106714 (rank : 552)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	479	Target Neighborhood Hits	777	Shared Neighborhood Hits	191
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

RYK_MOUSE
NC score	0.106677 (rank : 553)	θ value	θ > 10 (rank : 1246)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	52
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ARHG9_HUMAN
NC score	0.106666 (rank : 554)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	479	Target Neighborhood Hits	235	Shared Neighborhood Hits	92
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.106615 (rank : 555)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	479	Target Neighborhood Hits	234	Shared Neighborhood Hits	92
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

KNTC2_HUMAN
NC score	0.106592 (rank : 556)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	479	Target Neighborhood Hits	673	Shared Neighborhood Hits	185
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

LRC45_MOUSE
NC score	0.106556 (rank : 557)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	202
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

ROCK2_MOUSE
NC score	0.106551 (rank : 558)	θ value	0.47712 (rank : 268)
Query Neighborhood Hits	479	Target Neighborhood Hits	2072	Shared Neighborhood Hits	279
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

NCF4_HUMAN
NC score	0.106548 (rank : 559)	θ value	θ > 10 (rank : 1094)
Query Neighborhood Hits	479	Target Neighborhood Hits	161	Shared Neighborhood Hits	74
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GCC1_HUMAN
NC score	0.106463 (rank : 560)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	479	Target Neighborhood Hits	887	Shared Neighborhood Hits	199
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

HOOK2_HUMAN
NC score	0.106298 (rank : 561)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	479	Target Neighborhood Hits	714	Shared Neighborhood Hits	177
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

NUF2_HUMAN
NC score	0.106247 (rank : 562)	θ value	2.36792 (rank : 370)
Query Neighborhood Hits	479	Target Neighborhood Hits	661	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

ROS_HUMAN
NC score	0.106198 (rank : 563)	θ value	θ > 10 (rank : 1234)
Query Neighborhood Hits	479	Target Neighborhood Hits	907	Shared Neighborhood Hits	58
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

MAP9_HUMAN
NC score	0.106007 (rank : 564)	θ value	0.47712 (rank : 266)
Query Neighborhood Hits	479	Target Neighborhood Hits	518	Shared Neighborhood Hits	133
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

OPTN_HUMAN
NC score	0.105896 (rank : 565)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	479	Target Neighborhood Hits	827	Shared Neighborhood Hits	185
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

ANM2_HUMAN
NC score	0.105801 (rank : 566)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	85
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

M3K10_HUMAN
NC score	0.105687 (rank : 567)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	479	Target Neighborhood Hits	1071	Shared Neighborhood Hits	150
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

TPM2_MOUSE
NC score	0.105631 (rank : 568)	θ value	θ > 10 (rank : 1392)
Query Neighborhood Hits	479	Target Neighborhood Hits	676	Shared Neighborhood Hits	190
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

DYNA_HUMAN
NC score	0.105579 (rank : 569)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	479	Target Neighborhood Hits	1194	Shared Neighborhood Hits	212
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

TPM3_MOUSE
NC score	0.105387 (rank : 570)	θ value	θ > 10 (rank : 1394)
Query Neighborhood Hits	479	Target Neighborhood Hits	676	Shared Neighborhood Hits	183
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

RABE2_MOUSE
NC score	0.105341 (rank : 571)	θ value	θ > 10 (rank : 1194)
Query Neighborhood Hits	479	Target Neighborhood Hits	598	Shared Neighborhood Hits	173
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

TENS1_HUMAN
NC score	0.105188 (rank : 572)	θ value	1.06291 (rank : 317)
Query Neighborhood Hits	479	Target Neighborhood Hits	400	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TPM3_HUMAN
NC score	0.105089 (rank : 573)	θ value	θ > 10 (rank : 1393)
Query Neighborhood Hits	479	Target Neighborhood Hits	689	Shared Neighborhood Hits	184
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

DYNA_MOUSE
NC score	0.105073 (rank : 574)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	479	Target Neighborhood Hits	1084	Shared Neighborhood Hits	205
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

HOME2_HUMAN
NC score	0.105064 (rank : 575)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NSB8, O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7	Gene names	HOMER2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin).

LIPA2_MOUSE
NC score	0.105056 (rank : 576)	θ value	6.88961 (rank : 437)
Query Neighborhood Hits	479	Target Neighborhood Hits	1282	Shared Neighborhood Hits	232
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

ANR26_HUMAN
NC score	0.104937 (rank : 577)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	479	Target Neighborhood Hits	1614	Shared Neighborhood Hits	235
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

KNTC2_MOUSE
NC score	0.104855 (rank : 578)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	479	Target Neighborhood Hits	692	Shared Neighborhood Hits	187
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

FAK2_HUMAN
NC score	0.104786 (rank : 579)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	65
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TUFT1_HUMAN
NC score	0.104716 (rank : 580)	θ value	6.88961 (rank : 449)
Query Neighborhood Hits	479	Target Neighborhood Hits	686	Shared Neighborhood Hits	173
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

ES8L3_MOUSE
NC score	0.104666 (rank : 581)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	479	Target Neighborhood Hits	168	Shared Neighborhood Hits	85
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CTGE2_HUMAN
NC score	0.104618 (rank : 582)	θ value	5.27518 (rank : 418)
Query Neighborhood Hits	479	Target Neighborhood Hits	594	Shared Neighborhood Hits	173
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

FAK2_MOUSE
NC score	0.104573 (rank : 583)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EP15R_HUMAN
NC score	0.104393 (rank : 584)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	479	Target Neighborhood Hits	1083	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

CCD45_HUMAN
NC score	0.104377 (rank : 585)	θ value	0.62314 (rank : 275)
Query Neighborhood Hits	479	Target Neighborhood Hits	525	Shared Neighborhood Hits	141
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

TPM1_HUMAN
NC score	0.104341 (rank : 586)	θ value	6.88961 (rank : 447)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	193
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TACC1_MOUSE
NC score	0.104227 (rank : 587)	θ value	θ > 10 (rank : 1343)
Query Neighborhood Hits	479	Target Neighborhood Hits	667	Shared Neighborhood Hits	161
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

SPAG5_MOUSE
NC score	0.104157 (rank : 588)	θ value	θ > 10 (rank : 1290)
Query Neighborhood Hits	479	Target Neighborhood Hits	612	Shared Neighborhood Hits	165
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

AATK_MOUSE
NC score	0.104133 (rank : 589)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

TPM1_MOUSE
NC score	0.104101 (rank : 590)	θ value	θ > 10 (rank : 1390)
Query Neighborhood Hits	479	Target Neighborhood Hits	729	Shared Neighborhood Hits	195
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

MYO5A_MOUSE
NC score	0.103914 (rank : 591)	θ value	θ > 10 (rank : 1087)
Query Neighborhood Hits	479	Target Neighborhood Hits	1117	Shared Neighborhood Hits	217
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

LIPA1_HUMAN
NC score	0.103863 (rank : 592)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	479	Target Neighborhood Hits	1294	Shared Neighborhood Hits	231
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

MOES_MOUSE
NC score	0.103839 (rank : 593)	θ value	3.0926 (rank : 383)
Query Neighborhood Hits	479	Target Neighborhood Hits	923	Shared Neighborhood Hits	208
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

BPAEA_HUMAN
NC score	0.103611 (rank : 594)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	479	Target Neighborhood Hits	1369	Shared Neighborhood Hits	228
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

HIP1R_MOUSE
NC score	0.103521 (rank : 595)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	201
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

NEMO_MOUSE
NC score	0.103493 (rank : 596)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	479	Target Neighborhood Hits	658	Shared Neighborhood Hits	178
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

ROCK1_HUMAN
NC score	0.103430 (rank : 597)	θ value	θ > 10 (rank : 1227)
Query Neighborhood Hits	479	Target Neighborhood Hits	2000	Shared Neighborhood Hits	281
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

RFIP4_HUMAN
NC score	0.103222 (rank : 598)	θ value	θ > 10 (rank : 1208)
Query Neighborhood Hits	479	Target Neighborhood Hits	785	Shared Neighborhood Hits	191
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RRBP1_HUMAN
NC score	0.103210 (rank : 599)	θ value	θ > 10 (rank : 1237)
Query Neighborhood Hits	479	Target Neighborhood Hits	1306	Shared Neighborhood Hits	212
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

EPHAA_HUMAN
NC score	0.103115 (rank : 600)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	479	Target Neighborhood Hits	960	Shared Neighborhood Hits	61
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ROCK2_HUMAN
NC score	0.102804 (rank : 601)	θ value	3.0926 (rank : 387)
Query Neighborhood Hits	479	Target Neighborhood Hits	2073	Shared Neighborhood Hits	278
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ASPP1_HUMAN
NC score	0.102784 (rank : 602)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	479	Target Neighborhood Hits	956	Shared Neighborhood Hits	214
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RASF8_MOUSE
NC score	0.102780 (rank : 603)	θ value	θ > 10 (rank : 1201)
Query Neighborhood Hits	479	Target Neighborhood Hits	391	Shared Neighborhood Hits	140
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

DDR1_MOUSE
NC score	0.102757 (rank : 604)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	479	Target Neighborhood Hits	818	Shared Neighborhood Hits	60
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.102693 (rank : 605)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	479	Target Neighborhood Hits	819	Shared Neighborhood Hits	60
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

ERBB3_HUMAN
NC score	0.102403 (rank : 606)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	479	Target Neighborhood Hits	918	Shared Neighborhood Hits	60
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

TNK1_HUMAN
NC score	0.102330 (rank : 607)	θ value	θ > 10 (rank : 1382)
Query Neighborhood Hits	479	Target Neighborhood Hits	815	Shared Neighborhood Hits	62
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
NC score	0.102315 (rank : 608)	θ value	θ > 10 (rank : 1383)
Query Neighborhood Hits	479	Target Neighborhood Hits	806	Shared Neighborhood Hits	66
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TSC1_HUMAN
NC score	0.102283 (rank : 609)	θ value	θ > 10 (rank : 1403)
Query Neighborhood Hits	479	Target Neighborhood Hits	765	Shared Neighborhood Hits	176
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

KINH_MOUSE
NC score	0.102275 (rank : 610)	θ value	1.06291 (rank : 310)
Query Neighborhood Hits	479	Target Neighborhood Hits	1082	Shared Neighborhood Hits	226
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

RADI_MOUSE
NC score	0.102270 (rank : 611)	θ value	4.03905 (rank : 406)
Query Neighborhood Hits	479	Target Neighborhood Hits	773	Shared Neighborhood Hits	194
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

ERBB3_MOUSE
NC score	0.102147 (rank : 612)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	479	Target Neighborhood Hits	898	Shared Neighborhood Hits	59
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

LIPA2_HUMAN
NC score	0.102133 (rank : 613)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	479	Target Neighborhood Hits	1044	Shared Neighborhood Hits	215
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

SYNE1_HUMAN
NC score	0.101942 (rank : 614)	θ value	5.27518 (rank : 427)
Query Neighborhood Hits	479	Target Neighborhood Hits	1484	Shared Neighborhood Hits	226
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

EPHB6_HUMAN
NC score	0.101720 (rank : 615)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	479	Target Neighborhood Hits	912	Shared Neighborhood Hits	61
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

FLT3_MOUSE
NC score	0.101589 (rank : 616)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	58
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

ERBB2_HUMAN
NC score	0.101391 (rank : 617)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	479	Target Neighborhood Hits	1073	Shared Neighborhood Hits	63
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
NC score	0.101350 (rank : 618)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	479	Target Neighborhood Hits	918	Shared Neighborhood Hits	59
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB4_HUMAN
NC score	0.101214 (rank : 619)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	479	Target Neighborhood Hits	910	Shared Neighborhood Hits	60
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

AATK_HUMAN
NC score	0.101205 (rank : 620)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	479	Target Neighborhood Hits	1243	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

FLT3_HUMAN
NC score	0.101185 (rank : 621)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	60
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

IGF1R_MOUSE
NC score	0.101168 (rank : 622)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	479	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

EPHB6_MOUSE
NC score	0.101157 (rank : 623)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	61
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ANM2_MOUSE
NC score	0.101148 (rank : 624)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

IGF1R_HUMAN
NC score	0.101033 (rank : 625)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	479	Target Neighborhood Hits	977	Shared Neighborhood Hits	60
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MACF1_HUMAN
NC score	0.100965 (rank : 626)	θ value	4.03905 (rank : 404)
Query Neighborhood Hits	479	Target Neighborhood Hits	1341	Shared Neighborhood Hits	227
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

GOG8A_HUMAN
NC score	0.100854 (rank : 627)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	479	Target Neighborhood Hits	635	Shared Neighborhood Hits	175
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

PLCB4_HUMAN
NC score	0.100694 (rank : 628)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	479	Target Neighborhood Hits	658	Shared Neighborhood Hits	172
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

NTRK1_HUMAN
NC score	0.100689 (rank : 629)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	58
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

TEX14_HUMAN
NC score	0.100670 (rank : 630)	θ value	θ > 10 (rank : 1361)
Query Neighborhood Hits	479	Target Neighborhood Hits	1103	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CEP70_MOUSE
NC score	0.100669 (rank : 631)	θ value	1.81305 (rank : 334)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	159
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

FAK1_MOUSE
NC score	0.100624 (rank : 632)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	60
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

MERTK_HUMAN
NC score	0.100590 (rank : 633)	θ value	θ > 10 (rank : 1020)
Query Neighborhood Hits	479	Target Neighborhood Hits	988	Shared Neighborhood Hits	58
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MACOI_MOUSE
NC score	0.100573 (rank : 634)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	479	Target Neighborhood Hits	620	Shared Neighborhood Hits	173
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MIPO1_HUMAN
NC score	0.100568 (rank : 635)	θ value	θ > 10 (rank : 1028)
Query Neighborhood Hits	479	Target Neighborhood Hits	486	Shared Neighborhood Hits	156
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

FAK1_HUMAN
NC score	0.100552 (rank : 636)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

EPHA6_HUMAN
NC score	0.100389 (rank : 637)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	479	Target Neighborhood Hits	959	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

SPAG5_HUMAN
NC score	0.100358 (rank : 638)	θ value	θ > 10 (rank : 1289)
Query Neighborhood Hits	479	Target Neighborhood Hits	625	Shared Neighborhood Hits	161
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

LRRF2_MOUSE
NC score	0.100346 (rank : 639)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	479	Target Neighborhood Hits	556	Shared Neighborhood Hits	167
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

TXLNA_MOUSE
NC score	0.100304 (rank : 640)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	479	Target Neighborhood Hits	846	Shared Neighborhood Hits	197
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

INSRR_MOUSE
NC score	0.100241 (rank : 641)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	479	Target Neighborhood Hits	961	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

REN3B_HUMAN
NC score	0.100198 (rank : 642)	θ value	4.03905 (rank : 407)
Query Neighborhood Hits	479	Target Neighborhood Hits	412	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

INSRR_HUMAN
NC score	0.100173 (rank : 643)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	479	Target Neighborhood Hits	950	Shared Neighborhood Hits	59
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

EPHA6_MOUSE
NC score	0.100170 (rank : 644)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	479	Target Neighborhood Hits	946	Shared Neighborhood Hits	62
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

SNX23_HUMAN
NC score	0.100122 (rank : 645)	θ value	0.21417 (rank : 234)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	213
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

EPHA1_MOUSE
NC score	0.100103 (rank : 646)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	479	Target Neighborhood Hits	958	Shared Neighborhood Hits	63
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

MERTK_MOUSE
NC score	0.100095 (rank : 647)	θ value	θ > 10 (rank : 1021)
Query Neighborhood Hits	479	Target Neighborhood Hits	974	Shared Neighborhood Hits	58
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

CEP70_HUMAN
NC score	0.100027 (rank : 648)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	479	Target Neighborhood Hits	432	Shared Neighborhood Hits	154
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

S6OS1_HUMAN
NC score	0.099958 (rank : 649)	θ value	0.813845 (rank : 298)
Query Neighborhood Hits	479	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N1H7	Gene names	SIX6OS1, C14orf39
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

MYO5B_HUMAN
NC score	0.099910 (rank : 650)	θ value	θ > 10 (rank : 1088)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	206
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

CENPJ_HUMAN
NC score	0.099832 (rank : 651)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	479	Target Neighborhood Hits	721	Shared Neighborhood Hits	170
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

RON_MOUSE
NC score	0.099736 (rank : 652)	θ value	θ > 10 (rank : 1229)
Query Neighborhood Hits	479	Target Neighborhood Hits	836	Shared Neighborhood Hits	58
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

STK10_MOUSE
NC score	0.099645 (rank : 653)	θ value	0.0330416 (rank : 185)
Query Neighborhood Hits	479	Target Neighborhood Hits	2132	Shared Neighborhood Hits	257
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

NEMO_HUMAN
NC score	0.099632 (rank : 654)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	191
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

TPM4_MOUSE
NC score	0.099527 (rank : 655)	θ value	θ > 10 (rank : 1396)
Query Neighborhood Hits	479	Target Neighborhood Hits	703	Shared Neighborhood Hits	185
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

UFO_HUMAN
NC score	0.099510 (rank : 656)	θ value	θ > 10 (rank : 1424)
Query Neighborhood Hits	479	Target Neighborhood Hits	981	Shared Neighborhood Hits	61
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

CSF1R_HUMAN
NC score	0.099498 (rank : 657)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	479	Target Neighborhood Hits	943	Shared Neighborhood Hits	58
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

RUFY2_MOUSE
NC score	0.099493 (rank : 658)	θ value	θ > 10 (rank : 1241)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	199
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

CCD27_MOUSE
NC score	0.099413 (rank : 659)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	479	Target Neighborhood Hits	461	Shared Neighborhood Hits	153
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

EPHA1_HUMAN
NC score	0.099178 (rank : 660)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	479	Target Neighborhood Hits	997	Shared Neighborhood Hits	64
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

DDR2_HUMAN
NC score	0.099163 (rank : 661)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	479	Target Neighborhood Hits	818	Shared Neighborhood Hits	60
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EGFR_HUMAN
NC score	0.099157 (rank : 662)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	479	Target Neighborhood Hits	939	Shared Neighborhood Hits	60
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
NC score	0.099155 (rank : 663)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	479	Target Neighborhood Hits	927	Shared Neighborhood Hits	60
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

TPM4_HUMAN
NC score	0.098943 (rank : 664)	θ value	θ > 10 (rank : 1395)
Query Neighborhood Hits	479	Target Neighborhood Hits	525	Shared Neighborhood Hits	160
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

3BP2_HUMAN
NC score	0.098933 (rank : 665)	θ value	1.06291 (rank : 301)
Query Neighborhood Hits	479	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DDR2_MOUSE
NC score	0.098769 (rank : 666)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	479	Target Neighborhood Hits	813	Shared Neighborhood Hits	58
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA5_MOUSE
NC score	0.098747 (rank : 667)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	479	Target Neighborhood Hits	950	Shared Neighborhood Hits	61
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

INSR_HUMAN
NC score	0.098741 (rank : 668)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	479	Target Neighborhood Hits	963	Shared Neighborhood Hits	58
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ASPP2_HUMAN
NC score	0.098701 (rank : 669)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	479	Target Neighborhood Hits	1156	Shared Neighborhood Hits	233
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

UFO_MOUSE
NC score	0.098499 (rank : 670)	θ value	θ > 10 (rank : 1425)
Query Neighborhood Hits	479	Target Neighborhood Hits	988	Shared Neighborhood Hits	59
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

EP15_MOUSE
NC score	0.098492 (rank : 671)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	186
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

RON_HUMAN
NC score	0.098405 (rank : 672)	θ value	θ > 10 (rank : 1228)
Query Neighborhood Hits	479	Target Neighborhood Hits	842	Shared Neighborhood Hits	59
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

INSR_MOUSE
NC score	0.098323 (rank : 673)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	479	Target Neighborhood Hits	968	Shared Neighborhood Hits	59
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KIT_MOUSE
NC score	0.098280 (rank : 674)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	479	Target Neighborhood Hits	949	Shared Neighborhood Hits	59
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

TXLNB_HUMAN
NC score	0.098185 (rank : 675)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	479	Target Neighborhood Hits	912	Shared Neighborhood Hits	175
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

PGFRB_MOUSE
NC score	0.098149 (rank : 676)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	479	Target Neighborhood Hits	960	Shared Neighborhood Hits	59
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

STS2_HUMAN
NC score	0.098111 (rank : 677)	θ value	0.62314 (rank : 286)
Query Neighborhood Hits	479	Target Neighborhood Hits	108	Shared Neighborhood Hits	51
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

PGFRB_HUMAN
NC score	0.098046 (rank : 678)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	479	Target Neighborhood Hits	962	Shared Neighborhood Hits	58
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

MET_MOUSE
NC score	0.098009 (rank : 679)	θ value	θ > 10 (rank : 1023)
Query Neighborhood Hits	479	Target Neighborhood Hits	844	Shared Neighborhood Hits	58
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

CF152_HUMAN
NC score	0.097999 (rank : 680)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	479	Target Neighborhood Hits	704	Shared Neighborhood Hits	185
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

MRIP_HUMAN
NC score	0.097940 (rank : 681)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	479	Target Neighborhood Hits	578	Shared Neighborhood Hits	160
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

AL2SB_HUMAN
NC score	0.097832 (rank : 682)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	479	Target Neighborhood Hits	294	Shared Neighborhood Hits	127
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

CCD45_MOUSE
NC score	0.097818 (rank : 683)	θ value	2.36792 (rank : 352)
Query Neighborhood Hits	479	Target Neighborhood Hits	663	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

ROR2_MOUSE
NC score	0.097769 (rank : 684)	θ value	θ > 10 (rank : 1233)
Query Neighborhood Hits	479	Target Neighborhood Hits	1000	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

RET_HUMAN
NC score	0.097703 (rank : 685)	θ value	θ > 10 (rank : 1206)
Query Neighborhood Hits	479	Target Neighborhood Hits	873	Shared Neighborhood Hits	58
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

NTRK3_HUMAN
NC score	0.097692 (rank : 686)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	479	Target Neighborhood Hits	1115	Shared Neighborhood Hits	58
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PGFRA_MOUSE
NC score	0.097539 (rank : 687)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	479	Target Neighborhood Hits	975	Shared Neighborhood Hits	58
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

RRBP1_MOUSE
NC score	0.097529 (rank : 688)	θ value	θ > 10 (rank : 1238)
Query Neighborhood Hits	479	Target Neighborhood Hits	1650	Shared Neighborhood Hits	224
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

PGFRA_HUMAN
NC score	0.097458 (rank : 689)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	60
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TXLNB_MOUSE
NC score	0.097425 (rank : 690)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	479	Target Neighborhood Hits	640	Shared Neighborhood Hits	169
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

MET_HUMAN
NC score	0.097406 (rank : 691)	θ value	θ > 10 (rank : 1022)
Query Neighborhood Hits	479	Target Neighborhood Hits	831	Shared Neighborhood Hits	58
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA2_MOUSE
NC score	0.097377 (rank : 692)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	479	Target Neighborhood Hits	1020	Shared Neighborhood Hits	63
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

KIT_HUMAN
NC score	0.097255 (rank : 693)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	479	Target Neighborhood Hits	953	Shared Neighborhood Hits	58
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CNTRB_HUMAN
NC score	0.097220 (rank : 694)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	479	Target Neighborhood Hits	690	Shared Neighborhood Hits	173
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

EPHA8_MOUSE
NC score	0.097175 (rank : 695)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	479	Target Neighborhood Hits	969	Shared Neighborhood Hits	65
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA2_HUMAN
NC score	0.097172 (rank : 696)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	479	Target Neighborhood Hits	1021	Shared Neighborhood Hits	63
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ASPP1_MOUSE
NC score	0.097161 (rank : 697)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	479	Target Neighborhood Hits	1244	Shared Neighborhood Hits	216
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RET_MOUSE
NC score	0.096988 (rank : 698)	θ value	θ > 10 (rank : 1207)
Query Neighborhood Hits	479	Target Neighborhood Hits	884	Shared Neighborhood Hits	58
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EPHA8_HUMAN
NC score	0.096803 (rank : 699)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	479	Target Neighborhood Hits	956	Shared Neighborhood Hits	64
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

RFIP4_MOUSE
NC score	0.096747 (rank : 700)	θ value	θ > 10 (rank : 1209)
Query Neighborhood Hits	479	Target Neighborhood Hits	708	Shared Neighborhood Hits	185
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

CNTRB_MOUSE
NC score	0.096746 (rank : 701)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	479	Target Neighborhood Hits	1029	Shared Neighborhood Hits	193
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

EPHA4_HUMAN
NC score	0.096693 (rank : 702)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	479	Target Neighborhood Hits	975	Shared Neighborhood Hits	63
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

VDP_HUMAN
NC score	0.096693 (rank : 703)	θ value	θ > 10 (rank : 1434)
Query Neighborhood Hits	479	Target Neighborhood Hits	645	Shared Neighborhood Hits	166
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

CSF1R_MOUSE
NC score	0.096672 (rank : 704)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	479	Target Neighborhood Hits	983	Shared Neighborhood Hits	58
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

MACOI_HUMAN
NC score	0.096670 (rank : 705)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	479	Target Neighborhood Hits	650	Shared Neighborhood Hits	173
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACF4_HUMAN
NC score	0.096609 (rank : 706)	θ value	4.03905 (rank : 405)
Query Neighborhood Hits	479	Target Neighborhood Hits	1321	Shared Neighborhood Hits	216
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

RUFY1_HUMAN
NC score	0.096590 (rank : 707)	θ value	θ > 10 (rank : 1239)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	191
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SYNE2_HUMAN
NC score	0.096514 (rank : 708)	θ value	θ > 10 (rank : 1339)
Query Neighborhood Hits	479	Target Neighborhood Hits	1323	Shared Neighborhood Hits	222
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TYRO3_MOUSE
NC score	0.096475 (rank : 709)	θ value	θ > 10 (rank : 1422)
Query Neighborhood Hits	479	Target Neighborhood Hits	1007	Shared Neighborhood Hits	58
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

EPHA4_MOUSE
NC score	0.096409 (rank : 710)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	479	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

MRIP_MOUSE
NC score	0.096387 (rank : 711)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	479	Target Neighborhood Hits	569	Shared Neighborhood Hits	166
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

HIP1R_HUMAN
NC score	0.096363 (rank : 712)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	479	Target Neighborhood Hits	809	Shared Neighborhood Hits	198
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

TYRO3_HUMAN
NC score	0.096204 (rank : 713)	θ value	θ > 10 (rank : 1421)
Query Neighborhood Hits	479	Target Neighborhood Hits	995	Shared Neighborhood Hits	58
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

T3JAM_MOUSE
NC score	0.096195 (rank : 714)	θ value	θ > 10 (rank : 1341)
Query Neighborhood Hits	479	Target Neighborhood Hits	535	Shared Neighborhood Hits	164
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

MACF1_MOUSE
NC score	0.096107 (rank : 715)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	479	Target Neighborhood Hits	1313	Shared Neighborhood Hits	217
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

TRAK1_HUMAN
NC score	0.096084 (rank : 716)	θ value	θ > 10 (rank : 1399)
Query Neighborhood Hits	479	Target Neighborhood Hits	660	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

NDE1_HUMAN
NC score	0.096025 (rank : 717)	θ value	θ > 10 (rank : 1097)
Query Neighborhood Hits	479	Target Neighborhood Hits	823	Shared Neighborhood Hits	200
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

EPHB4_HUMAN
NC score	0.095980 (rank : 718)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	479	Target Neighborhood Hits	1056	Shared Neighborhood Hits	63
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB2_HUMAN
NC score	0.095891 (rank : 719)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	479	Target Neighborhood Hits	983	Shared Neighborhood Hits	63
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
NC score	0.095853 (rank : 720)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	479	Target Neighborhood Hits	982	Shared Neighborhood Hits	63
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

ES8L2_MOUSE
NC score	0.095762 (rank : 721)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	479	Target Neighborhood Hits	169	Shared Neighborhood Hits	83
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

S6OS1_MOUSE
NC score	0.095578 (rank : 722)	θ value	0.0736092 (rank : 202)
Query Neighborhood Hits	479	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q9CTN5, Q9D5F5, Q9D5Y9	Gene names	Six6os1
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

EPHB3_MOUSE
NC score	0.095561 (rank : 723)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	479	Target Neighborhood Hits	996	Shared Neighborhood Hits	62
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB3_HUMAN
NC score	0.095560 (rank : 724)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	479	Target Neighborhood Hits	996	Shared Neighborhood Hits	63
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

ROR2_HUMAN
NC score	0.095560 (rank : 725)	θ value	θ > 10 (rank : 1232)
Query Neighborhood Hits	479	Target Neighborhood Hits	1014	Shared Neighborhood Hits	58
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

CCD96_MOUSE
NC score	0.095559 (rank : 726)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	479	Target Neighborhood Hits	704	Shared Neighborhood Hits	167
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

ROR1_MOUSE
NC score	0.095472 (rank : 727)	θ value	θ > 10 (rank : 1231)
Query Neighborhood Hits	479	Target Neighborhood Hits	1025	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

EPHB4_MOUSE
NC score	0.095383 (rank : 728)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	479	Target Neighborhood Hits	1013	Shared Neighborhood Hits	63
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

TXLNA_HUMAN
NC score	0.095292 (rank : 729)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	479	Target Neighborhood Hits	982	Shared Neighborhood Hits	187
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

EPHA5_HUMAN
NC score	0.095256 (rank : 730)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	63
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

ES8L2_HUMAN
NC score	0.095233 (rank : 731)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	479	Target Neighborhood Hits	193	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

DMD_MOUSE
NC score	0.095091 (rank : 732)	θ value	6.88961 (rank : 432)
Query Neighborhood Hits	479	Target Neighborhood Hits	1111	Shared Neighborhood Hits	215
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

ROR1_HUMAN
NC score	0.095049 (rank : 733)	θ value	θ > 10 (rank : 1230)
Query Neighborhood Hits	479	Target Neighborhood Hits	1018	Shared Neighborhood Hits	58
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

EPHB1_HUMAN
NC score	0.094904 (rank : 734)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	479	Target Neighborhood Hits	988	Shared Neighborhood Hits	62
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

HIP1_HUMAN
NC score	0.094810 (rank : 735)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	479	Target Neighborhood Hits	1016	Shared Neighborhood Hits	214
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

EFS_HUMAN
NC score	0.094688 (rank : 736)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	479	Target Neighborhood Hits	348	Shared Neighborhood Hits	93
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

CDR2_MOUSE
NC score	0.094510 (rank : 737)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	479	Target Neighborhood Hits	482	Shared Neighborhood Hits	150
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CEP57_HUMAN
NC score	0.094366 (rank : 738)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	479	Target Neighborhood Hits	576	Shared Neighborhood Hits	185
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

EPHA3_MOUSE
NC score	0.094283 (rank : 739)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	479	Target Neighborhood Hits	1009	Shared Neighborhood Hits	62
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

RUFY3_HUMAN
NC score	0.094211 (rank : 740)	θ value	8.99809 (rank : 471)
Query Neighborhood Hits	479	Target Neighborhood Hits	594	Shared Neighborhood Hits	174
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

EPHA7_HUMAN
NC score	0.094060 (rank : 741)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	479	Target Neighborhood Hits	1053	Shared Neighborhood Hits	63
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FGFR4_MOUSE
NC score	0.093990 (rank : 742)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	479	Target Neighborhood Hits	1026	Shared Neighborhood Hits	55
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

HC127_HUMAN
NC score	0.093977 (rank : 743)	θ value	2.36792 (rank : 356)
Query Neighborhood Hits	479	Target Neighborhood Hits	292	Shared Neighborhood Hits	118
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
NC score	0.093977 (rank : 744)	θ value	2.36792 (rank : 357)
Query Neighborhood Hits	479	Target Neighborhood Hits	292	Shared Neighborhood Hits	118
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

EPHA7_MOUSE
NC score	0.093955 (rank : 745)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	479	Target Neighborhood Hits	1025	Shared Neighborhood Hits	63
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

NTRK2_HUMAN
NC score	0.093911 (rank : 746)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	479	Target Neighborhood Hits	1081	Shared Neighborhood Hits	58
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.093906 (rank : 747)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	58
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

CRCM_HUMAN
NC score	0.093874 (rank : 748)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	479	Target Neighborhood Hits	520	Shared Neighborhood Hits	164
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

EPHA3_HUMAN
NC score	0.093833 (rank : 749)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	479	Target Neighborhood Hits	1005	Shared Neighborhood Hits	59
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

T3JAM_HUMAN
NC score	0.093499 (rank : 750)	θ value	θ > 10 (rank : 1340)
Query Neighborhood Hits	479	Target Neighborhood Hits	533	Shared Neighborhood Hits	144
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

RPGR1_HUMAN
NC score	0.093472 (rank : 751)	θ value	θ > 10 (rank : 1235)
Query Neighborhood Hits	479	Target Neighborhood Hits	578	Shared Neighborhood Hits	159
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CCD27_HUMAN
NC score	0.093439 (rank : 752)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	479	Target Neighborhood Hits	594	Shared Neighborhood Hits	161
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

RUFY1_MOUSE
NC score	0.093336 (rank : 753)	θ value	θ > 10 (rank : 1240)
Query Neighborhood Hits	479	Target Neighborhood Hits	765	Shared Neighborhood Hits	177
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RBM25_HUMAN
NC score	0.093150 (rank : 754)	θ value	θ > 10 (rank : 1204)
Query Neighborhood Hits	479	Target Neighborhood Hits	682	Shared Neighborhood Hits	150
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

MYO6_HUMAN
NC score	0.093041 (rank : 755)	θ value	θ > 10 (rank : 1090)
Query Neighborhood Hits	479	Target Neighborhood Hits	727	Shared Neighborhood Hits	182
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

STK10_HUMAN
NC score	0.092881 (rank : 756)	θ value	4.03905 (rank : 408)
Query Neighborhood Hits	479	Target Neighborhood Hits	1921	Shared Neighborhood Hits	237
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

HOME1_HUMAN
NC score	0.092849 (rank : 757)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	479	Target Neighborhood Hits	564	Shared Neighborhood Hits	158
SwissProt Accessions	Q86YM7, O96003, Q86YM5	Gene names	HOMER1, SYN47
Domain Architecture
Description	Homer protein homolog 1.

CCD96_HUMAN
NC score	0.092677 (rank : 758)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	479	Target Neighborhood Hits	595	Shared Neighborhood Hits	151
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

TIE1_HUMAN
NC score	0.092663 (rank : 759)	θ value	θ > 10 (rank : 1369)
Query Neighborhood Hits	479	Target Neighborhood Hits	1241	Shared Neighborhood Hits	61
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

MPP9_HUMAN
NC score	0.092407 (rank : 760)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	479	Target Neighborhood Hits	529	Shared Neighborhood Hits	153
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

FGFR4_HUMAN
NC score	0.092398 (rank : 761)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	479	Target Neighborhood Hits	1037	Shared Neighborhood Hits	58
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

TIE1_MOUSE
NC score	0.092366 (rank : 762)	θ value	θ > 10 (rank : 1370)
Query Neighborhood Hits	479	Target Neighborhood Hits	1266	Shared Neighborhood Hits	61
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
NC score	0.092355 (rank : 763)	θ value	θ > 10 (rank : 1371)
Query Neighborhood Hits	479	Target Neighborhood Hits	1192	Shared Neighborhood Hits	61
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
NC score	0.092241 (rank : 764)	θ value	θ > 10 (rank : 1372)
Query Neighborhood Hits	479	Target Neighborhood Hits	1204	Shared Neighborhood Hits	61
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

CF182_MOUSE
NC score	0.091991 (rank : 765)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	479	Target Neighborhood Hits	551	Shared Neighborhood Hits	169
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

BCAR1_MOUSE
NC score	0.091956 (rank : 766)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	479	Target Neighborhood Hits	438	Shared Neighborhood Hits	100
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DLG5_HUMAN
NC score	0.091781 (rank : 767)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	211
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

MLKL_HUMAN
NC score	0.091778 (rank : 768)	θ value	θ > 10 (rank : 1029)
Query Neighborhood Hits	479	Target Neighborhood Hits	600	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MUSK_MOUSE
NC score	0.091740 (rank : 769)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	479	Target Neighborhood Hits	1057	Shared Neighborhood Hits	58
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PLCB2_HUMAN
NC score	0.091574 (rank : 770)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	479	Target Neighborhood Hits	608	Shared Neighborhood Hits	163
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

MUSK_HUMAN
NC score	0.091503 (rank : 771)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	479	Target Neighborhood Hits	1074	Shared Neighborhood Hits	58
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

SSNA1_MOUSE
NC score	0.091432 (rank : 772)	θ value	0.47712 (rank : 270)
Query Neighborhood Hits	479	Target Neighborhood Hits	182	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JJ94	Gene names	Ssna1
Domain Architecture	No domain graphic available
Description	Sjoegren syndrome nuclear autoantigen 1 homolog.

JAK1_MOUSE
NC score	0.091254 (rank : 773)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	479	Target Neighborhood Hits	854	Shared Neighborhood Hits	65
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

GUC2F_HUMAN
NC score	0.091254 (rank : 774)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	479	Target Neighborhood Hits	740	Shared Neighborhood Hits	60
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

BRE1B_MOUSE
NC score	0.091243 (rank : 775)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	479	Target Neighborhood Hits	970	Shared Neighborhood Hits	179
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

BRE1B_HUMAN
NC score	0.091132 (rank : 776)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	479	Target Neighborhood Hits	1040	Shared Neighborhood Hits	182
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

FGFR2_MOUSE
NC score	0.091030 (rank : 777)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	479	Target Neighborhood Hits	1062	Shared Neighborhood Hits	58
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
NC score	0.091017 (rank : 778)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	479	Target Neighborhood Hits	1042	Shared Neighborhood Hits	58
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

TRAK2_HUMAN
NC score	0.090880 (rank : 779)	θ value	θ > 10 (rank : 1400)
Query Neighborhood Hits	479	Target Neighborhood Hits	476	Shared Neighborhood Hits	150
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

HOME1_MOUSE
NC score	0.090866 (rank : 780)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	479	Target Neighborhood Hits	630	Shared Neighborhood Hits	167
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

CEP57_MOUSE
NC score	0.090820 (rank : 781)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	479	Target Neighborhood Hits	580	Shared Neighborhood Hits	177
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

ARHG4_MOUSE
NC score	0.090811 (rank : 782)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	479	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

JAK1_HUMAN
NC score	0.090800 (rank : 783)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	479	Target Neighborhood Hits	858	Shared Neighborhood Hits	64
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

AMRP_HUMAN
NC score	0.090682 (rank : 784)	θ value	0.125558 (rank : 211)
Query Neighborhood Hits	479	Target Neighborhood Hits	126	Shared Neighborhood Hits	55
SwissProt Accessions	P30533	Gene names	LRPAP1, A2MRAP
Domain Architecture
Description	Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2- MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP).

KIF5C_MOUSE
NC score	0.090620 (rank : 785)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	479	Target Neighborhood Hits	1040	Shared Neighborhood Hits	228
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

IF2P_HUMAN
NC score	0.090611 (rank : 786)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	479	Target Neighborhood Hits	889	Shared Neighborhood Hits	161
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

FGFR2_HUMAN
NC score	0.090598 (rank : 787)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	479	Target Neighborhood Hits	1062	Shared Neighborhood Hits	58
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

TRAIP_MOUSE
NC score	0.090595 (rank : 788)	θ value	θ > 10 (rank : 1398)
Query Neighborhood Hits	479	Target Neighborhood Hits	745	Shared Neighborhood Hits	171
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

RUSC1_HUMAN
NC score	0.090523 (rank : 789)	θ value	θ > 10 (rank : 1243)
Query Neighborhood Hits	479	Target Neighborhood Hits	226	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

FGFR3_MOUSE
NC score	0.090283 (rank : 790)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	479	Target Neighborhood Hits	1059	Shared Neighborhood Hits	58
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

TRAIP_HUMAN
NC score	0.090202 (rank : 791)	θ value	θ > 10 (rank : 1397)
Query Neighborhood Hits	479	Target Neighborhood Hits	780	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

CF152_MOUSE
NC score	0.089939 (rank : 792)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	479	Target Neighborhood Hits	597	Shared Neighborhood Hits	160
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CCDC7_HUMAN
NC score	0.089729 (rank : 793)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	479	Target Neighborhood Hits	253	Shared Neighborhood Hits	99
SwissProt Accessions	Q96M83, Q8IVQ0, Q8NEQ0	Gene names	CCDC7
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 7.

CT032_HUMAN
NC score	0.089683 (rank : 794)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	479	Target Neighborhood Hits	235	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

VGFR3_MOUSE
NC score	0.089637 (rank : 795)	θ value	θ > 10 (rank : 1441)
Query Neighborhood Hits	479	Target Neighborhood Hits	1056	Shared Neighborhood Hits	58
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_MOUSE
NC score	0.089621 (rank : 796)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	479	Target Neighborhood Hits	1068	Shared Neighborhood Hits	58
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.089606 (rank : 797)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	479	Target Neighborhood Hits	1069	Shared Neighborhood Hits	58
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

TYK2_MOUSE
NC score	0.089509 (rank : 798)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_HUMAN
NC score	0.089467 (rank : 799)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	479	Target Neighborhood Hits	827	Shared Neighborhood Hits	58
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

VGFR3_HUMAN
NC score	0.089360 (rank : 800)	θ value	θ > 10 (rank : 1440)
Query Neighborhood Hits	479	Target Neighborhood Hits	1037	Shared Neighborhood Hits	58
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

BRAF1_HUMAN
NC score	0.089283 (rank : 801)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	479	Target Neighborhood Hits	883	Shared Neighborhood Hits	70
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

LIPA3_HUMAN
NC score	0.089250 (rank : 802)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	189
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

GP73_HUMAN
NC score	0.089220 (rank : 803)	θ value	0.813845 (rank : 293)
Query Neighborhood Hits	479	Target Neighborhood Hits	309	Shared Neighborhood Hits	108
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

RAF1_HUMAN
NC score	0.089200 (rank : 804)	θ value	θ > 10 (rank : 1196)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	69
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MAP1A_HUMAN
NC score	0.089163 (rank : 805)	θ value	3.0926 (rank : 382)
Query Neighborhood Hits	479	Target Neighborhood Hits	1626	Shared Neighborhood Hits	204
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

LZTS1_MOUSE
NC score	0.089104 (rank : 806)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	479	Target Neighborhood Hits	540	Shared Neighborhood Hits	154
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

CA065_HUMAN
NC score	0.088992 (rank : 807)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	479	Target Neighborhood Hits	469	Shared Neighborhood Hits	128
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

ARAF_MOUSE
NC score	0.088927 (rank : 808)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	68
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

KIF4A_HUMAN
NC score	0.088889 (rank : 809)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	479	Target Neighborhood Hits	1159	Shared Neighborhood Hits	205
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF5C_HUMAN
NC score	0.088729 (rank : 810)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	479	Target Neighborhood Hits	974	Shared Neighborhood Hits	221
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

RAF1_MOUSE
NC score	0.088651 (rank : 811)	θ value	θ > 10 (rank : 1197)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	69
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

TAOK1_HUMAN
NC score	0.088510 (rank : 812)	θ value	5.27518 (rank : 428)
Query Neighborhood Hits	479	Target Neighborhood Hits	1734	Shared Neighborhood Hits	234
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

ARAF_HUMAN
NC score	0.088445 (rank : 813)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	479	Target Neighborhood Hits	924	Shared Neighborhood Hits	69
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

MLKL_MOUSE
NC score	0.088392 (rank : 814)	θ value	θ > 10 (rank : 1030)
Query Neighborhood Hits	479	Target Neighborhood Hits	707	Shared Neighborhood Hits	55
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RUFY3_MOUSE
NC score	0.088387 (rank : 815)	θ value	θ > 10 (rank : 1242)
Query Neighborhood Hits	479	Target Neighborhood Hits	579	Shared Neighborhood Hits	172
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PHLB1_HUMAN
NC score	0.088299 (rank : 816)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	479	Target Neighborhood Hits	1038	Shared Neighborhood Hits	188
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

ANPRB_MOUSE
NC score	0.088275 (rank : 817)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	479	Target Neighborhood Hits	607	Shared Neighborhood Hits	62
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

IASPP_HUMAN
NC score	0.088246 (rank : 818)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	479	Target Neighborhood Hits	688	Shared Neighborhood Hits	101
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PTK7_HUMAN
NC score	0.088234 (rank : 819)	θ value	θ > 10 (rank : 1190)
Query Neighborhood Hits	479	Target Neighborhood Hits	1103	Shared Neighborhood Hits	59
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

TYK2_HUMAN
NC score	0.088116 (rank : 820)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	479	Target Neighborhood Hits	841	Shared Neighborhood Hits	58
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TAOK1_MOUSE
NC score	0.088015 (rank : 821)	θ value	5.27518 (rank : 429)
Query Neighborhood Hits	479	Target Neighborhood Hits	1720	Shared Neighborhood Hits	231
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

GUC2C_HUMAN
NC score	0.087973 (rank : 822)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	479	Target Neighborhood Hits	624	Shared Neighborhood Hits	51
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ANPRB_HUMAN
NC score	0.087834 (rank : 823)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	479	Target Neighborhood Hits	646	Shared Neighborhood Hits	62
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARHG5_HUMAN
NC score	0.087684 (rank : 824)	θ value	0.21417 (rank : 228)
Query Neighborhood Hits	479	Target Neighborhood Hits	172	Shared Neighborhood Hits	62
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

LIPB1_HUMAN
NC score	0.087500 (rank : 825)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	479	Target Neighborhood Hits	640	Shared Neighborhood Hits	180
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

DMD_HUMAN
NC score	0.087293 (rank : 826)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	479	Target Neighborhood Hits	1135	Shared Neighborhood Hits	207
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

PININ_HUMAN
NC score	0.087262 (rank : 827)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

JAK2_MOUSE
NC score	0.087109 (rank : 828)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	479	Target Neighborhood Hits	839	Shared Neighborhood Hits	63
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

VGFR2_MOUSE
NC score	0.086938 (rank : 829)	θ value	θ > 10 (rank : 1439)
Query Neighborhood Hits	479	Target Neighborhood Hits	1089	Shared Neighborhood Hits	58
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

PPIP2_MOUSE
NC score	0.086913 (rank : 830)	θ value	θ > 10 (rank : 1184)
Query Neighborhood Hits	479	Target Neighborhood Hits	308	Shared Neighborhood Hits	110
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

ILK_MOUSE
NC score	0.086897 (rank : 831)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	479	Target Neighborhood Hits	858	Shared Neighborhood Hits	62
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

VGFR2_HUMAN
NC score	0.086870 (rank : 832)	θ value	θ > 10 (rank : 1438)
Query Neighborhood Hits	479	Target Neighborhood Hits	1103	Shared Neighborhood Hits	58
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

ANPRA_MOUSE
NC score	0.086832 (rank : 833)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	479	Target Neighborhood Hits	600	Shared Neighborhood Hits	57
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.086733 (rank : 834)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	479	Target Neighborhood Hits	612	Shared Neighborhood Hits	56
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

NDE1_MOUSE
NC score	0.086708 (rank : 835)	θ value	θ > 10 (rank : 1098)
Query Neighborhood Hits	479	Target Neighborhood Hits	602	Shared Neighborhood Hits	177
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

JAK2_HUMAN
NC score	0.086649 (rank : 836)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	63
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_MOUSE
NC score	0.086595 (rank : 837)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	479	Target Neighborhood Hits	821	Shared Neighborhood Hits	58
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

SSNA1_HUMAN
NC score	0.086445 (rank : 838)	θ value	0.62314 (rank : 285)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	62
SwissProt Accessions	O43805, Q6FG70, Q9BVW8	Gene names	SSNA1, NA14
Domain Architecture
Description	Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa).

MYO7A_MOUSE
NC score	0.086301 (rank : 839)	θ value	0.000602161 (rank : 117)
Query Neighborhood Hits	479	Target Neighborhood Hits	235	Shared Neighborhood Hits	63
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

CT096_HUMAN
NC score	0.086188 (rank : 840)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	479	Target Neighborhood Hits	438	Shared Neighborhood Hits	132
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

TNNT2_HUMAN
NC score	0.086146 (rank : 841)	θ value	θ > 10 (rank : 1384)
Query Neighborhood Hits	479	Target Neighborhood Hits	433	Shared Neighborhood Hits	132
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

VDP_MOUSE
NC score	0.086015 (rank : 842)	θ value	θ > 10 (rank : 1435)
Query Neighborhood Hits	479	Target Neighborhood Hits	469	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

ILK1_HUMAN
NC score	0.085970 (rank : 843)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	479	Target Neighborhood Hits	857	Shared Neighborhood Hits	62
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

LZTS1_HUMAN
NC score	0.085970 (rank : 844)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

BCAR1_HUMAN
NC score	0.085724 (rank : 845)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	479	Target Neighborhood Hits	554	Shared Neighborhood Hits	104
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DREB_MOUSE
NC score	0.085544 (rank : 846)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	479	Target Neighborhood Hits	446	Shared Neighborhood Hits	112
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

CF182_HUMAN
NC score	0.085518 (rank : 847)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	479	Target Neighborhood Hits	474	Shared Neighborhood Hits	156
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

AMOL2_MOUSE
NC score	0.085384 (rank : 848)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	479	Target Neighborhood Hits	591	Shared Neighborhood Hits	162
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

MFAP1_MOUSE
NC score	0.085307 (rank : 849)	θ value	θ > 10 (rank : 1025)
Query Neighborhood Hits	479	Target Neighborhood Hits	353	Shared Neighborhood Hits	111
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

TCRG1_HUMAN
NC score	0.085191 (rank : 850)	θ value	θ > 10 (rank : 1354)
Query Neighborhood Hits	479	Target Neighborhood Hits	929	Shared Neighborhood Hits	160
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

ILK2_HUMAN
NC score	0.085178 (rank : 851)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	62
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

TCRG1_MOUSE
NC score	0.085121 (rank : 852)	θ value	θ > 10 (rank : 1355)
Query Neighborhood Hits	479	Target Neighborhood Hits	947	Shared Neighborhood Hits	161
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

VGFR1_HUMAN
NC score	0.084993 (rank : 853)	θ value	θ > 10 (rank : 1436)
Query Neighborhood Hits	479	Target Neighborhood Hits	1109	Shared Neighborhood Hits	58
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

MYO6_MOUSE
NC score	0.084937 (rank : 854)	θ value	θ > 10 (rank : 1091)
Query Neighborhood Hits	479	Target Neighborhood Hits	586	Shared Neighborhood Hits	164
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

VGFR1_MOUSE
NC score	0.084817 (rank : 855)	θ value	θ > 10 (rank : 1437)
Query Neighborhood Hits	479	Target Neighborhood Hits	1118	Shared Neighborhood Hits	58
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

SKIL_MOUSE
NC score	0.084805 (rank : 856)	θ value	θ > 10 (rank : 1274)
Query Neighborhood Hits	479	Target Neighborhood Hits	719	Shared Neighborhood Hits	170
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

RBBP8_HUMAN
NC score	0.084613 (rank : 857)	θ value	θ > 10 (rank : 1202)
Query Neighborhood Hits	479	Target Neighborhood Hits	476	Shared Neighborhood Hits	134
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

CCD93_HUMAN
NC score	0.084559 (rank : 858)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	479	Target Neighborhood Hits	600	Shared Neighborhood Hits	153
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

MLTK_MOUSE
NC score	0.084554 (rank : 859)	θ value	θ > 10 (rank : 1032)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.084489 (rank : 860)	θ value	θ > 10 (rank : 1031)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

KIF5A_HUMAN
NC score	0.084437 (rank : 861)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	205
SwissProt Accessions	Q12840, Q4LE26	Gene names	KIF5A, NKHC1
Domain Architecture
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

AMOL2_HUMAN
NC score	0.084347 (rank : 862)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	479	Target Neighborhood Hits	603	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

KSR2_HUMAN
NC score	0.084342 (rank : 863)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	479	Target Neighborhood Hits	920	Shared Neighborhood Hits	69
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

ES8L1_HUMAN
NC score	0.084199 (rank : 864)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	479	Target Neighborhood Hits	162	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CAR14_MOUSE
NC score	0.083543 (rank : 865)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	479	Target Neighborhood Hits	526	Shared Neighborhood Hits	149
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

UTRO_HUMAN
NC score	0.083465 (rank : 866)	θ value	θ > 10 (rank : 1433)
Query Neighborhood Hits	479	Target Neighborhood Hits	960	Shared Neighborhood Hits	197
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

NGEF_MOUSE
NC score	0.083014 (rank : 867)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	479	Target Neighborhood Hits	228	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RIPK1_MOUSE
NC score	0.082971 (rank : 868)	θ value	θ > 10 (rank : 1218)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	60
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

M3K7_MOUSE
NC score	0.082751 (rank : 869)	θ value	1.81305 (rank : 343)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	81
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.082696 (rank : 870)	θ value	1.81305 (rank : 342)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	80
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

PPIP2_HUMAN
NC score	0.082598 (rank : 871)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	479	Target Neighborhood Hits	254	Shared Neighborhood Hits	98
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

KSR1_HUMAN
NC score	0.082567 (rank : 872)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	68
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

TTC3_HUMAN
NC score	0.082391 (rank : 873)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	479	Target Neighborhood Hits	664	Shared Neighborhood Hits	164
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

SLK_HUMAN
NC score	0.082354 (rank : 874)	θ value	θ > 10 (rank : 1277)
Query Neighborhood Hits	479	Target Neighborhood Hits	1775	Shared Neighborhood Hits	247
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

KSR1_MOUSE
NC score	0.082254 (rank : 875)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	479	Target Neighborhood Hits	870	Shared Neighborhood Hits	66
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

TAOK3_HUMAN
NC score	0.082222 (rank : 876)	θ value	θ > 10 (rank : 1347)
Query Neighborhood Hits	479	Target Neighborhood Hits	1494	Shared Neighborhood Hits	216
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

SLK_MOUSE
NC score	0.082140 (rank : 877)	θ value	θ > 10 (rank : 1278)
Query Neighborhood Hits	479	Target Neighborhood Hits	1798	Shared Neighborhood Hits	244
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

IASPP_MOUSE
NC score	0.082104 (rank : 878)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	479	Target Neighborhood Hits	1024	Shared Neighborhood Hits	117
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

EZRI_MOUSE
NC score	0.082064 (rank : 879)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	479	Target Neighborhood Hits	693	Shared Neighborhood Hits	194
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

CTGE4_HUMAN
NC score	0.081985 (rank : 880)	θ value	2.36792 (rank : 354)
Query Neighborhood Hits	479	Target Neighborhood Hits	393	Shared Neighborhood Hits	137
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

CCD42_HUMAN
NC score	0.081735 (rank : 881)	θ value	4.03905 (rank : 395)
Query Neighborhood Hits	479	Target Neighborhood Hits	406	Shared Neighborhood Hits	137
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

RIPK1_HUMAN
NC score	0.081668 (rank : 882)	θ value	θ > 10 (rank : 1217)
Query Neighborhood Hits	479	Target Neighborhood Hits	891	Shared Neighborhood Hits	59
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIMB2_MOUSE
NC score	0.081543 (rank : 883)	θ value	θ > 10 (rank : 1216)
Query Neighborhood Hits	479	Target Neighborhood Hits	246	Shared Neighborhood Hits	82
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

EZRI_HUMAN
NC score	0.081500 (rank : 884)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	479	Target Neighborhood Hits	663	Shared Neighborhood Hits	177
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

COVA1_HUMAN
NC score	0.081215 (rank : 885)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	479	Target Neighborhood Hits	416	Shared Neighborhood Hits	134
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

RIPK2_MOUSE
NC score	0.081046 (rank : 886)	θ value	θ > 10 (rank : 1220)
Query Neighborhood Hits	479	Target Neighborhood Hits	776	Shared Neighborhood Hits	58
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

TEKT1_MOUSE
NC score	0.080940 (rank : 887)	θ value	5.27518 (rank : 430)
Query Neighborhood Hits	479	Target Neighborhood Hits	399	Shared Neighborhood Hits	133
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

BMR1B_HUMAN
NC score	0.080937 (rank : 888)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	479	Target Neighborhood Hits	760	Shared Neighborhood Hits	60
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

ZWINT_MOUSE
NC score	0.080854 (rank : 889)	θ value	θ > 10 (rank : 1457)
Query Neighborhood Hits	479	Target Neighborhood Hits	497	Shared Neighborhood Hits	147
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

BMR1B_MOUSE
NC score	0.080816 (rank : 890)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	479	Target Neighborhood Hits	758	Shared Neighborhood Hits	60
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

CDR2_HUMAN
NC score	0.080690 (rank : 891)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	479	Target Neighborhood Hits	404	Shared Neighborhood Hits	137
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

MOS_HUMAN
NC score	0.080498 (rank : 892)	θ value	θ > 10 (rank : 1036)
Query Neighborhood Hits	479	Target Neighborhood Hits	829	Shared Neighborhood Hits	58
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
NC score	0.080408 (rank : 893)	θ value	θ > 10 (rank : 1037)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	58
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

KIF4A_MOUSE
NC score	0.080345 (rank : 894)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	479	Target Neighborhood Hits	1033	Shared Neighborhood Hits	203
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

GBP4_HUMAN
NC score	0.080248 (rank : 895)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	479	Target Neighborhood Hits	484	Shared Neighborhood Hits	154
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

IRAK3_MOUSE
NC score	0.080193 (rank : 896)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	479	Target Neighborhood Hits	628	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

PININ_MOUSE
NC score	0.080184 (rank : 897)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	479	Target Neighborhood Hits	777	Shared Neighborhood Hits	153
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

MYO7A_HUMAN
NC score	0.080179 (rank : 898)	θ value	0.0252991 (rank : 176)
Query Neighborhood Hits	479	Target Neighborhood Hits	209	Shared Neighborhood Hits	56
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

NGEF_HUMAN
NC score	0.080082 (rank : 899)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RABE2_HUMAN
NC score	0.079906 (rank : 900)	θ value	θ > 10 (rank : 1193)
Query Neighborhood Hits	479	Target Neighborhood Hits	545	Shared Neighborhood Hits	153
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

TAOK3_MOUSE
NC score	0.079778 (rank : 901)	θ value	θ > 10 (rank : 1348)
Query Neighborhood Hits	479	Target Neighborhood Hits	1458	Shared Neighborhood Hits	212
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

IRAK1_MOUSE
NC score	0.079672 (rank : 902)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	479	Target Neighborhood Hits	784	Shared Neighborhood Hits	59
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

RIPK2_HUMAN
NC score	0.079625 (rank : 903)	θ value	θ > 10 (rank : 1219)
Query Neighborhood Hits	479	Target Neighborhood Hits	774	Shared Neighborhood Hits	58
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

MMRN1_HUMAN
NC score	0.079600 (rank : 904)	θ value	θ > 10 (rank : 1033)
Query Neighborhood Hits	479	Target Neighborhood Hits	636	Shared Neighborhood Hits	134
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

NOXO1_MOUSE
NC score	0.079550 (rank : 905)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	479	Target Neighborhood Hits	114	Shared Neighborhood Hits	57
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

RAI14_MOUSE
NC score	0.079496 (rank : 906)	θ value	θ > 10 (rank : 1199)
Query Neighborhood Hits	479	Target Neighborhood Hits	1505	Shared Neighborhood Hits	217
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RAI14_HUMAN
NC score	0.079379 (rank : 907)	θ value	θ > 10 (rank : 1198)
Query Neighborhood Hits	479	Target Neighborhood Hits	1367	Shared Neighborhood Hits	211
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

ANR18_HUMAN
NC score	0.079348 (rank : 908)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	479	Target Neighborhood Hits	1106	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

M4K4_MOUSE
NC score	0.079258 (rank : 909)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	479	Target Neighborhood Hits	1560	Shared Neighborhood Hits	214
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TAOK2_MOUSE
NC score	0.079242 (rank : 910)	θ value	θ > 10 (rank : 1346)
Query Neighborhood Hits	479	Target Neighborhood Hits	1373	Shared Neighborhood Hits	195
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

LIPB2_HUMAN
NC score	0.079092 (rank : 911)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	479	Target Neighborhood Hits	599	Shared Neighborhood Hits	168
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

CU013_HUMAN
NC score	0.079071 (rank : 912)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	479	Target Neighborhood Hits	405	Shared Neighborhood Hits	124
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

M3K13_HUMAN
NC score	0.078942 (rank : 913)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	64
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

NEST_HUMAN
NC score	0.078699 (rank : 914)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	479	Target Neighborhood Hits	1305	Shared Neighborhood Hits	181
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

M3K12_HUMAN
NC score	0.078526 (rank : 915)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	479	Target Neighborhood Hits	940	Shared Neighborhood Hits	66
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

LZTS2_HUMAN
NC score	0.078517 (rank : 916)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	479	Target Neighborhood Hits	427	Shared Neighborhood Hits	137
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

M3K12_MOUSE
NC score	0.078495 (rank : 917)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	479	Target Neighborhood Hits	957	Shared Neighborhood Hits	67
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

LIPB1_MOUSE
NC score	0.078371 (rank : 918)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	479	Target Neighborhood Hits	727	Shared Neighborhood Hits	175
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

IMMT_HUMAN
NC score	0.078199 (rank : 919)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	479	Target Neighborhood Hits	494	Shared Neighborhood Hits	148
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

RIPK3_MOUSE
NC score	0.078145 (rank : 920)	θ value	θ > 10 (rank : 1222)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

EPS8_MOUSE
NC score	0.078113 (rank : 921)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	479	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

RIPK3_HUMAN
NC score	0.077862 (rank : 922)	θ value	θ > 10 (rank : 1221)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

GUC2D_HUMAN
NC score	0.077849 (rank : 923)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	56
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

DDEF2_HUMAN
NC score	0.077777 (rank : 924)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	479	Target Neighborhood Hits	599	Shared Neighborhood Hits	116
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ENAH_HUMAN
NC score	0.077591 (rank : 925)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	479	Target Neighborhood Hits	784	Shared Neighborhood Hits	154
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

IRAK3_HUMAN
NC score	0.077587 (rank : 926)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	479	Target Neighborhood Hits	644	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

SAFB2_HUMAN
NC score	0.077524 (rank : 927)	θ value	θ > 10 (rank : 1247)
Query Neighborhood Hits	479	Target Neighborhood Hits	720	Shared Neighborhood Hits	139
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

NDEL1_HUMAN
NC score	0.077484 (rank : 928)	θ value	θ > 10 (rank : 1099)
Query Neighborhood Hits	479	Target Neighborhood Hits	415	Shared Neighborhood Hits	140
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

GUC2E_MOUSE
NC score	0.077465 (rank : 929)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	479	Target Neighborhood Hits	692	Shared Neighborhood Hits	54
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

CEP35_HUMAN
NC score	0.077461 (rank : 930)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	479	Target Neighborhood Hits	811	Shared Neighborhood Hits	172
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

GUC2G_MOUSE
NC score	0.077308 (rank : 931)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	479	Target Neighborhood Hits	644	Shared Neighborhood Hits	48
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

RGNEF_MOUSE
NC score	0.077241 (rank : 932)	θ value	θ > 10 (rank : 1210)
Query Neighborhood Hits	479	Target Neighborhood Hits	641	Shared Neighborhood Hits	136
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ES8L1_MOUSE
NC score	0.077196 (rank : 933)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	479	Target Neighborhood Hits	143	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

BMR1A_MOUSE
NC score	0.076974 (rank : 934)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	479	Target Neighborhood Hits	758	Shared Neighborhood Hits	58
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

AN30A_HUMAN
NC score	0.076964 (rank : 935)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	479	Target Neighborhood Hits	1119	Shared Neighborhood Hits	177
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

NDEL1_MOUSE
NC score	0.076948 (rank : 936)	θ value	θ > 10 (rank : 1100)
Query Neighborhood Hits	479	Target Neighborhood Hits	420	Shared Neighborhood Hits	140
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

BMR1A_HUMAN
NC score	0.076853 (rank : 937)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	479	Target Neighborhood Hits	759	Shared Neighborhood Hits	58
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

CASL_MOUSE
NC score	0.076692 (rank : 938)	θ value	8.99809 (rank : 452)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	84
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

MRCKG_HUMAN
NC score	0.076389 (rank : 939)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	479	Target Neighborhood Hits	1519	Shared Neighborhood Hits	225
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KIF5A_MOUSE
NC score	0.076319 (rank : 940)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	479	Target Neighborhood Hits	859	Shared Neighborhood Hits	204
SwissProt Accessions	P33175, Q5DTP1, Q6PDY7, Q9Z2F9	Gene names	Kif5a, Kiaa4086, Kif5, Nkhc1
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

RUSC1_MOUSE
NC score	0.076228 (rank : 941)	θ value	θ > 10 (rank : 1244)
Query Neighborhood Hits	479	Target Neighborhood Hits	206	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SPTB2_MOUSE
NC score	0.076105 (rank : 942)	θ value	θ > 10 (rank : 1301)
Query Neighborhood Hits	479	Target Neighborhood Hits	770	Shared Neighborhood Hits	173
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

K0552_HUMAN
NC score	0.076002 (rank : 943)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	479	Target Neighborhood Hits	442	Shared Neighborhood Hits	133
SwissProt Accessions	O60299	Gene names	KIAA0552
Domain Architecture
Description	Protein KIAA0552.

MCF2L_MOUSE
NC score	0.075807 (rank : 944)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	479	Target Neighborhood Hits	255	Shared Neighborhood Hits	78
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

CCD38_HUMAN
NC score	0.075780 (rank : 945)	θ value	1.81305 (rank : 333)
Query Neighborhood Hits	479	Target Neighborhood Hits	287	Shared Neighborhood Hits	104
SwissProt Accessions	Q502W7, Q8N835	Gene names	CCDC38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

DDEF1_MOUSE
NC score	0.075642 (rank : 946)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	479	Target Neighborhood Hits	592	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

TRIO_HUMAN
NC score	0.075526 (rank : 947)	θ value	θ > 10 (rank : 1402)
Query Neighborhood Hits	479	Target Neighborhood Hits	1580	Shared Neighborhood Hits	198
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SPTB2_HUMAN
NC score	0.075395 (rank : 948)	θ value	θ > 10 (rank : 1300)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	173
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MYO3A_HUMAN
NC score	0.075297 (rank : 949)	θ value	θ > 10 (rank : 1083)
Query Neighborhood Hits	479	Target Neighborhood Hits	1033	Shared Neighborhood Hits	107
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

SYGP1_HUMAN
NC score	0.075283 (rank : 950)	θ value	0.279714 (rank : 247)
Query Neighborhood Hits	479	Target Neighborhood Hits	589	Shared Neighborhood Hits	152
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

DDEF2_MOUSE
NC score	0.075069 (rank : 951)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	479	Target Neighborhood Hits	625	Shared Neighborhood Hits	108
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CLC4F_HUMAN
NC score	0.075038 (rank : 952)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	479	Target Neighborhood Hits	513	Shared Neighborhood Hits	130
SwissProt Accessions	Q8N1N0	Gene names	CLEC4F, CLECSF13
Domain Architecture	No domain graphic available
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13).

RIMB2_HUMAN
NC score	0.075010 (rank : 953)	θ value	θ > 10 (rank : 1215)
Query Neighborhood Hits	479	Target Neighborhood Hits	263	Shared Neighborhood Hits	69
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

AMOT_HUMAN
NC score	0.074932 (rank : 954)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	479	Target Neighborhood Hits	712	Shared Neighborhood Hits	155
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

M4K4_HUMAN
NC score	0.074916 (rank : 955)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	479	Target Neighborhood Hits	1589	Shared Neighborhood Hits	224
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TNIK_HUMAN
NC score	0.074835 (rank : 956)	θ value	θ > 10 (rank : 1380)
Query Neighborhood Hits	479	Target Neighborhood Hits	1570	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

IRAK1_HUMAN
NC score	0.074798 (rank : 957)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK4_HUMAN
NC score	0.074732 (rank : 958)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	479	Target Neighborhood Hits	816	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

CENPH_HUMAN
NC score	0.074635 (rank : 959)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	479	Target Neighborhood Hits	335	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

KI21A_HUMAN
NC score	0.074621 (rank : 960)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	479	Target Neighborhood Hits	1543	Shared Neighborhood Hits	226
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

LIPA3_MOUSE
NC score	0.074582 (rank : 961)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	479	Target Neighborhood Hits	636	Shared Neighborhood Hits	163
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

PHLB1_MOUSE
NC score	0.074442 (rank : 962)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	479	Target Neighborhood Hits	678	Shared Neighborhood Hits	140
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

LIPB2_MOUSE
NC score	0.074426 (rank : 963)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	479	Target Neighborhood Hits	570	Shared Neighborhood Hits	159
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

SKIL_HUMAN
NC score	0.074358 (rank : 964)	θ value	θ > 10 (rank : 1273)
Query Neighborhood Hits	479	Target Neighborhood Hits	460	Shared Neighborhood Hits	147
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

TESK2_HUMAN
NC score	0.074014 (rank : 965)	θ value	θ > 10 (rank : 1359)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

SNX9_HUMAN
NC score	0.073767 (rank : 966)	θ value	θ > 10 (rank : 1287)
Query Neighborhood Hits	479	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

EPS8_HUMAN
NC score	0.073760 (rank : 967)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

CAR10_HUMAN
NC score	0.073736 (rank : 968)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	479	Target Neighborhood Hits	569	Shared Neighborhood Hits	156
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

WDR67_HUMAN
NC score	0.073720 (rank : 969)	θ value	θ > 10 (rank : 1444)
Query Neighborhood Hits	479	Target Neighborhood Hits	782	Shared Neighborhood Hits	156
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

LMNB1_HUMAN
NC score	0.073675 (rank : 970)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	479	Target Neighborhood Hits	714	Shared Neighborhood Hits	188
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

CASL_HUMAN
NC score	0.073562 (rank : 971)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	479	Target Neighborhood Hits	259	Shared Neighborhood Hits	86
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

GRP3_HUMAN
NC score	0.073422 (rank : 972)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	479	Target Neighborhood Hits	131	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

COVA1_MOUSE
NC score	0.073397 (rank : 973)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	479	Target Neighborhood Hits	335	Shared Neighborhood Hits	103
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

MAP9_MOUSE
NC score	0.073203 (rank : 974)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	479	Target Neighborhood Hits	529	Shared Neighborhood Hits	127
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

LMNB1_MOUSE
NC score	0.073111 (rank : 975)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	479	Target Neighborhood Hits	719	Shared Neighborhood Hits	186
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

KI21A_MOUSE
NC score	0.073093 (rank : 976)	θ value	2.36792 (rank : 369)
Query Neighborhood Hits	479	Target Neighborhood Hits	1317	Shared Neighborhood Hits	204
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

RIPK5_MOUSE
NC score	0.073008 (rank : 977)	θ value	θ > 10 (rank : 1225)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	70
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

TEKT1_HUMAN
NC score	0.072991 (rank : 978)	θ value	4.03905 (rank : 409)
Query Neighborhood Hits	479	Target Neighborhood Hits	289	Shared Neighborhood Hits	111
SwissProt Accessions	Q969V4	Gene names	TEKT1
Domain Architecture
Description	Tektin-1.

LIMK1_MOUSE
NC score	0.072965 (rank : 979)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	479	Target Neighborhood Hits	1008	Shared Neighborhood Hits	63
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

TESK2_MOUSE
NC score	0.072965 (rank : 980)	θ value	θ > 10 (rank : 1360)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

NFM_MOUSE
NC score	0.072838 (rank : 981)	θ value	3.0926 (rank : 386)
Query Neighborhood Hits	479	Target Neighborhood Hits	1159	Shared Neighborhood Hits	212
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

LIMK1_HUMAN
NC score	0.072790 (rank : 982)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	479	Target Neighborhood Hits	1005	Shared Neighborhood Hits	62
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

APOA4_MOUSE
NC score	0.072787 (rank : 983)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	125
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

STS1_MOUSE
NC score	0.072706 (rank : 984)	θ value	8.99809 (rank : 474)
Query Neighborhood Hits	479	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BAIP2_HUMAN
NC score	0.072694 (rank : 985)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	479	Target Neighborhood Hits	192	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

MRCKG_MOUSE
NC score	0.072568 (rank : 986)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	479	Target Neighborhood Hits	1466	Shared Neighborhood Hits	217
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

LZTS2_MOUSE
NC score	0.072457 (rank : 987)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	479	Target Neighborhood Hits	423	Shared Neighborhood Hits	132
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

IRAK4_MOUSE
NC score	0.072340 (rank : 988)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	479	Target Neighborhood Hits	820	Shared Neighborhood Hits	59
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

RIPK5_HUMAN
NC score	0.072249 (rank : 989)	θ value	θ > 10 (rank : 1224)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	64
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

LMNA_MOUSE
NC score	0.072195 (rank : 990)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	479	Target Neighborhood Hits	661	Shared Neighborhood Hits	182
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

SAFB2_MOUSE
NC score	0.072134 (rank : 991)	θ value	θ > 10 (rank : 1248)
Query Neighborhood Hits	479	Target Neighborhood Hits	581	Shared Neighborhood Hits	129
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

PLCB3_MOUSE
NC score	0.072116 (rank : 992)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	479	Target Neighborhood Hits	344	Shared Neighborhood Hits	118
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

MORC3_HUMAN
NC score	0.071927 (rank : 993)	θ value	θ > 10 (rank : 1035)
Query Neighborhood Hits	479	Target Neighborhood Hits	489	Shared Neighborhood Hits	146
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

DREB_HUMAN
NC score	0.071719 (rank : 994)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	479	Target Neighborhood Hits	450	Shared Neighborhood Hits	116
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

TNI3K_MOUSE
NC score	0.071572 (rank : 995)	θ value	θ > 10 (rank : 1379)
Query Neighborhood Hits	479	Target Neighborhood Hits	1079	Shared Neighborhood Hits	63
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

MYO3A_MOUSE
NC score	0.071253 (rank : 996)	θ value	θ > 10 (rank : 1084)
Query Neighborhood Hits	479	Target Neighborhood Hits	902	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

SNX9_MOUSE
NC score	0.071209 (rank : 997)	θ value	θ > 10 (rank : 1288)
Query Neighborhood Hits	479	Target Neighborhood Hits	141	Shared Neighborhood Hits	56
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

TNI3K_HUMAN
NC score	0.071196 (rank : 998)	θ value	θ > 10 (rank : 1378)
Query Neighborhood Hits	479	Target Neighborhood Hits	1084	Shared Neighborhood Hits	63
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

U2AFM_HUMAN
NC score	0.071183 (rank : 999)	θ value	4.03905 (rank : 411)
Query Neighborhood Hits	479	Target Neighborhood Hits	577	Shared Neighborhood Hits	143
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

TGFR1_HUMAN
NC score	0.071107 (rank : 1000)	θ value	θ > 10 (rank : 1363)
Query Neighborhood Hits	479	Target Neighborhood Hits	755	Shared Neighborhood Hits	58
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.071014 (rank : 1001)	θ value	θ > 10 (rank : 1364)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	58
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

STIM1_HUMAN
NC score	0.070992 (rank : 1002)	θ value	θ > 10 (rank : 1316)
Query Neighborhood Hits	479	Target Neighborhood Hits	665	Shared Neighborhood Hits	162
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

NFM_HUMAN
NC score	0.070853 (rank : 1003)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	479	Target Neighborhood Hits	1328	Shared Neighborhood Hits	209
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

ACVL1_MOUSE
NC score	0.070830 (rank : 1004)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	479	Target Neighborhood Hits	739	Shared Neighborhood Hits	58
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

CCD93_MOUSE
NC score	0.070786 (rank : 1005)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	479	Target Neighborhood Hits	362	Shared Neighborhood Hits	121
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

OLR1_MOUSE
NC score	0.070638 (rank : 1006)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	479	Target Neighborhood Hits	596	Shared Neighborhood Hits	149
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

TESK1_MOUSE
NC score	0.070530 (rank : 1007)	θ value	θ > 10 (rank : 1358)
Query Neighborhood Hits	479	Target Neighborhood Hits	862	Shared Neighborhood Hits	59
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

ACVL1_HUMAN
NC score	0.070392 (rank : 1008)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	58
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TESK1_HUMAN
NC score	0.070363 (rank : 1009)	θ value	θ > 10 (rank : 1357)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	61
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

LMNA_HUMAN
NC score	0.070296 (rank : 1010)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	479	Target Neighborhood Hits	653	Shared Neighborhood Hits	179
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

LIMK2_MOUSE
NC score	0.070252 (rank : 1011)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	479	Target Neighborhood Hits	998	Shared Neighborhood Hits	64
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_HUMAN
NC score	0.070187 (rank : 1012)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	479	Target Neighborhood Hits	986	Shared Neighborhood Hits	64
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

STIM1_MOUSE
NC score	0.070102 (rank : 1013)	θ value	θ > 10 (rank : 1317)
Query Neighborhood Hits	479	Target Neighborhood Hits	660	Shared Neighborhood Hits	161
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

PLVAP_HUMAN
NC score	0.069969 (rank : 1014)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	479	Target Neighborhood Hits	397	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

BRAP_HUMAN
NC score	0.069889 (rank : 1015)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	479	Target Neighborhood Hits	560	Shared Neighborhood Hits	138
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

LMNB2_HUMAN
NC score	0.069858 (rank : 1016)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	479	Target Neighborhood Hits	723	Shared Neighborhood Hits	184
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

ACV1C_HUMAN
NC score	0.069800 (rank : 1017)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	479	Target Neighborhood Hits	709	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1B_MOUSE
NC score	0.069766 (rank : 1018)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	58
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

STS1_HUMAN
NC score	0.069750 (rank : 1019)	θ value	θ > 10 (rank : 1330)
Query Neighborhood Hits	479	Target Neighborhood Hits	106	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ACV1B_HUMAN
NC score	0.069735 (rank : 1020)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	479	Target Neighborhood Hits	753	Shared Neighborhood Hits	58
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

CCD42_MOUSE
NC score	0.069724 (rank : 1021)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	479	Target Neighborhood Hits	284	Shared Neighborhood Hits	115
SwissProt Accessions	Q5SV66, Q8BNY1	Gene names	Ccdc42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

LETM1_HUMAN
NC score	0.069679 (rank : 1022)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	479	Target Neighborhood Hits	338	Shared Neighborhood Hits	116
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

RENT2_HUMAN
NC score	0.069679 (rank : 1023)	θ value	θ > 10 (rank : 1205)
Query Neighborhood Hits	479	Target Neighborhood Hits	618	Shared Neighborhood Hits	139
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

TARA_MOUSE
NC score	0.069673 (rank : 1024)	θ value	θ > 10 (rank : 1350)
Query Neighborhood Hits	479	Target Neighborhood Hits	1133	Shared Neighborhood Hits	171
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ACV1C_MOUSE
NC score	0.069520 (rank : 1025)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

BCN1_HUMAN
NC score	0.069424 (rank : 1026)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	479	Target Neighborhood Hits	395	Shared Neighborhood Hits	137
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

TOPK_HUMAN
NC score	0.069187 (rank : 1027)	θ value	θ > 10 (rank : 1388)
Query Neighborhood Hits	479	Target Neighborhood Hits	605	Shared Neighborhood Hits	49
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ANR12_HUMAN
NC score	0.069131 (rank : 1028)	θ value	5.27518 (rank : 414)
Query Neighborhood Hits	479	Target Neighborhood Hits	1081	Shared Neighborhood Hits	172
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

GBP2_MOUSE
NC score	0.069104 (rank : 1029)	θ value	0.125558 (rank : 215)
Query Neighborhood Hits	479	Target Neighborhood Hits	323	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Z0E6, Q8CIC6, Q921N2, Q9R1I0	Gene names	Gbp2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (mGBP2) (mGBP-2).

MERL_HUMAN
NC score	0.068962 (rank : 1030)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	479	Target Neighborhood Hits	532	Shared Neighborhood Hits	157
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

BFSP1_HUMAN
NC score	0.068940 (rank : 1031)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	479	Target Neighborhood Hits	508	Shared Neighborhood Hits	151
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

3BP5_HUMAN
NC score	0.068844 (rank : 1032)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	479	Target Neighborhood Hits	375	Shared Neighborhood Hits	120
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

MERL_MOUSE
NC score	0.068804 (rank : 1033)	θ value	θ > 10 (rank : 1019)
Query Neighborhood Hits	479	Target Neighborhood Hits	524	Shared Neighborhood Hits	156
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

ARHGG_MOUSE
NC score	0.068340 (rank : 1034)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	479	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

TAOK2_HUMAN
NC score	0.068152 (rank : 1035)	θ value	θ > 10 (rank : 1345)
Query Neighborhood Hits	479	Target Neighborhood Hits	1172	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

ECT2_MOUSE
NC score	0.068072 (rank : 1036)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	479	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NUCB2_MOUSE
NC score	0.068041 (rank : 1037)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	479	Target Neighborhood Hits	459	Shared Neighborhood Hits	134
SwissProt Accessions	P81117	Gene names	Nucb2, Nefa
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA).

PHLB3_HUMAN
NC score	0.068020 (rank : 1038)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	479	Target Neighborhood Hits	304	Shared Neighborhood Hits	100
SwissProt Accessions	Q6NSJ2, Q8N7Z4	Gene names	PHLDB3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 3.

INVO_MOUSE
NC score	0.067682 (rank : 1039)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	479	Target Neighborhood Hits	474	Shared Neighborhood Hits	106
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

TOPK_MOUSE
NC score	0.067328 (rank : 1040)	θ value	θ > 10 (rank : 1389)
Query Neighborhood Hits	479	Target Neighborhood Hits	618	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

RPGR1_MOUSE
NC score	0.067232 (rank : 1041)	θ value	θ > 10 (rank : 1236)
Query Neighborhood Hits	479	Target Neighborhood Hits	713	Shared Neighborhood Hits	154
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

MFAP1_HUMAN
NC score	0.067145 (rank : 1042)	θ value	θ > 10 (rank : 1024)
Query Neighborhood Hits	479	Target Neighborhood Hits	321	Shared Neighborhood Hits	96
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

IRAK2_HUMAN
NC score	0.067113 (rank : 1043)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	479	Target Neighborhood Hits	714	Shared Neighborhood Hits	51
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ACVR1_MOUSE
NC score	0.067075 (rank : 1044)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	479	Target Neighborhood Hits	768	Shared Neighborhood Hits	58
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

PKHG1_HUMAN
NC score	0.066810 (rank : 1045)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	479	Target Neighborhood Hits	174	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ACVR1_HUMAN
NC score	0.066730 (rank : 1046)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	479	Target Neighborhood Hits	760	Shared Neighborhood Hits	58
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

AMOL1_HUMAN
NC score	0.066721 (rank : 1047)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	479	Target Neighborhood Hits	435	Shared Neighborhood Hits	131
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

ECT2_HUMAN
NC score	0.066705 (rank : 1048)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	479	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VIME_MOUSE
NC score	0.066652 (rank : 1049)	θ value	θ > 10 (rank : 1443)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	198
SwissProt Accessions	P20152, O08704, Q8CCH1	Gene names	Vim
Domain Architecture
Description	Vimentin.

ZRF1_MOUSE
NC score	0.066640 (rank : 1050)	θ value	θ > 10 (rank : 1456)
Query Neighborhood Hits	479	Target Neighborhood Hits	414	Shared Neighborhood Hits	116
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

LMNB2_MOUSE
NC score	0.066618 (rank : 1051)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	479	Target Neighborhood Hits	674	Shared Neighborhood Hits	182
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

3BP5_MOUSE
NC score	0.066594 (rank : 1052)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	479	Target Neighborhood Hits	346	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

LRSM1_HUMAN
NC score	0.066560 (rank : 1053)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	479	Target Neighborhood Hits	1078	Shared Neighborhood Hits	182
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

BI2L1_HUMAN
NC score	0.066455 (rank : 1054)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	479	Target Neighborhood Hits	156	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BAIP2_MOUSE
NC score	0.066341 (rank : 1055)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	479	Target Neighborhood Hits	185	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

MYO3B_HUMAN
NC score	0.066257 (rank : 1056)	θ value	θ > 10 (rank : 1085)
Query Neighborhood Hits	479	Target Neighborhood Hits	923	Shared Neighborhood Hits	76
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

KPCB_MOUSE
NC score	0.066151 (rank : 1057)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	479	Target Neighborhood Hits	1117	Shared Neighborhood Hits	80
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MINK1_HUMAN
NC score	0.066136 (rank : 1058)	θ value	θ > 10 (rank : 1026)
Query Neighborhood Hits	479	Target Neighborhood Hits	1477	Shared Neighborhood Hits	190
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

CJ068_HUMAN
NC score	0.066070 (rank : 1059)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	479	Target Neighborhood Hits	316	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

GCP60_HUMAN
NC score	0.066070 (rank : 1060)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	479	Target Neighborhood Hits	419	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

AMRP_MOUSE
NC score	0.066028 (rank : 1061)	θ value	5.27518 (rank : 413)
Query Neighborhood Hits	479	Target Neighborhood Hits	173	Shared Neighborhood Hits	79
SwissProt Accessions	P55302	Gene names	Lrpap1
Domain Architecture
Description	Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2- MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin-binding protein 44) (HBP-44).

MINK1_MOUSE
NC score	0.066001 (rank : 1062)	θ value	θ > 10 (rank : 1027)
Query Neighborhood Hits	479	Target Neighborhood Hits	1451	Shared Neighborhood Hits	188
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

KPCD_HUMAN
NC score	0.065955 (rank : 1063)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	479	Target Neighborhood Hits	900	Shared Neighborhood Hits	75
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCB_HUMAN
NC score	0.065862 (rank : 1064)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	479	Target Neighborhood Hits	1121	Shared Neighborhood Hits	80
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

GP73_MOUSE
NC score	0.065641 (rank : 1065)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	479	Target Neighborhood Hits	506	Shared Neighborhood Hits	118
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

CDC37_HUMAN
NC score	0.065586 (rank : 1066)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	479	Target Neighborhood Hits	506	Shared Neighborhood Hits	124
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

NEK11_HUMAN
NC score	0.065513 (rank : 1067)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	479	Target Neighborhood Hits	1043	Shared Neighborhood Hits	118
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PRC1_MOUSE
NC score	0.065496 (rank : 1068)	θ value	θ > 10 (rank : 1186)
Query Neighborhood Hits	479	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

NEB2_MOUSE
NC score	0.065442 (rank : 1069)	θ value	θ > 10 (rank : 1103)
Query Neighborhood Hits	479	Target Neighborhood Hits	889	Shared Neighborhood Hits	169
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

ARHGA_HUMAN
NC score	0.065415 (rank : 1070)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	479	Target Neighborhood Hits	187	Shared Neighborhood Hits	41
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PLCB3_HUMAN
NC score	0.065393 (rank : 1071)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	479	Target Neighborhood Hits	445	Shared Neighborhood Hits	112
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

KPCD_MOUSE
NC score	0.065368 (rank : 1072)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	75
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

ANKK1_MOUSE
NC score	0.065099 (rank : 1073)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	479	Target Neighborhood Hits	1072	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ENAH_MOUSE
NC score	0.064900 (rank : 1074)	θ value	6.88961 (rank : 433)
Query Neighborhood Hits	479	Target Neighborhood Hits	919	Shared Neighborhood Hits	137
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GNRP_HUMAN
NC score	0.064866 (rank : 1075)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	479	Target Neighborhood Hits	239	Shared Neighborhood Hits	61
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CCD22_MOUSE
NC score	0.064845 (rank : 1076)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	479	Target Neighborhood Hits	268	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

VIME_HUMAN
NC score	0.064479 (rank : 1077)	θ value	θ > 10 (rank : 1442)
Query Neighborhood Hits	479	Target Neighborhood Hits	706	Shared Neighborhood Hits	197
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

ARHGA_MOUSE
NC score	0.064435 (rank : 1078)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	479	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

U2AFL_HUMAN
NC score	0.064417 (rank : 1079)	θ value	2.36792 (rank : 372)
Query Neighborhood Hits	479	Target Neighborhood Hits	503	Shared Neighborhood Hits	138
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

ARHG3_HUMAN
NC score	0.064312 (rank : 1080)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	479	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

BCN1_MOUSE
NC score	0.064285 (rank : 1081)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	479	Target Neighborhood Hits	367	Shared Neighborhood Hits	125
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

SPC24_HUMAN
NC score	0.064285 (rank : 1082)	θ value	θ > 10 (rank : 1291)
Query Neighborhood Hits	479	Target Neighborhood Hits	324	Shared Neighborhood Hits	109
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

ANKK1_HUMAN
NC score	0.064190 (rank : 1083)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	479	Target Neighborhood Hits	1075	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

TS101_HUMAN
NC score	0.064087 (rank : 1084)	θ value	8.99809 (rank : 478)
Query Neighborhood Hits	479	Target Neighborhood Hits	359	Shared Neighborhood Hits	122
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

KPCA_HUMAN
NC score	0.064035 (rank : 1085)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	479	Target Neighborhood Hits	1070	Shared Neighborhood Hits	84
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PREX1_HUMAN
NC score	0.064034 (rank : 1086)	θ value	θ > 10 (rank : 1187)
Query Neighborhood Hits	479	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

KPCT_HUMAN
NC score	0.064021 (rank : 1087)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	479	Target Neighborhood Hits	897	Shared Neighborhood Hits	74
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCA_MOUSE
NC score	0.063980 (rank : 1088)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	479	Target Neighborhood Hits	1067	Shared Neighborhood Hits	84
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

CAR10_MOUSE
NC score	0.063841 (rank : 1089)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	479	Target Neighborhood Hits	407	Shared Neighborhood Hits	134
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

LRRF1_HUMAN
NC score	0.063628 (rank : 1090)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	479	Target Neighborhood Hits	625	Shared Neighborhood Hits	136
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

ARHGG_HUMAN
NC score	0.063531 (rank : 1091)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	479	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

GLE1_MOUSE
NC score	0.063464 (rank : 1092)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	479	Target Neighborhood Hits	504	Shared Neighborhood Hits	125
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

ARHG3_MOUSE
NC score	0.063443 (rank : 1093)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	479	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

CI096_HUMAN
NC score	0.063394 (rank : 1094)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	479	Target Neighborhood Hits	821	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

NEB2_HUMAN
NC score	0.063352 (rank : 1095)	θ value	θ > 10 (rank : 1102)
Query Neighborhood Hits	479	Target Neighborhood Hits	883	Shared Neighborhood Hits	167
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

TNNT3_HUMAN
NC score	0.063140 (rank : 1096)	θ value	θ > 10 (rank : 1386)
Query Neighborhood Hits	479	Target Neighborhood Hits	327	Shared Neighborhood Hits	114
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

GBP2_HUMAN
NC score	0.063089 (rank : 1097)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	479	Target Neighborhood Hits	349	Shared Neighborhood Hits	122
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

RIPK4_HUMAN
NC score	0.063038 (rank : 1098)	θ value	θ > 10 (rank : 1223)
Query Neighborhood Hits	479	Target Neighborhood Hits	1094	Shared Neighborhood Hits	65
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

KPCT_MOUSE
NC score	0.063022 (rank : 1099)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	74
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

AMHR2_HUMAN
NC score	0.062980 (rank : 1100)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	58
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ZC313_HUMAN
NC score	0.062821 (rank : 1101)	θ value	θ > 10 (rank : 1454)
Query Neighborhood Hits	479	Target Neighborhood Hits	772	Shared Neighborhood Hits	123
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

STXB4_HUMAN
NC score	0.062779 (rank : 1102)	θ value	θ > 10 (rank : 1331)
Query Neighborhood Hits	479	Target Neighborhood Hits	616	Shared Neighborhood Hits	143
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

KIF3B_MOUSE
NC score	0.062447 (rank : 1103)	θ value	8.99809 (rank : 463)
Query Neighborhood Hits	479	Target Neighborhood Hits	533	Shared Neighborhood Hits	164
SwissProt Accessions	Q61771	Gene names	Kif3b
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B).

JIP2_MOUSE
NC score	0.062437 (rank : 1104)	θ value	2.36792 (rank : 362)
Query Neighborhood Hits	479	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

TIAM1_MOUSE
NC score	0.062434 (rank : 1105)	θ value	θ > 10 (rank : 1368)
Query Neighborhood Hits	479	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

NEK11_MOUSE
NC score	0.062432 (rank : 1106)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	479	Target Neighborhood Hits	875	Shared Neighborhood Hits	66
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

APOA4_HUMAN
NC score	0.062365 (rank : 1107)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	479	Target Neighborhood Hits	399	Shared Neighborhood Hits	112
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

NUCB2_HUMAN
NC score	0.062364 (rank : 1108)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	479	Target Neighborhood Hits	321	Shared Neighborhood Hits	121
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

TIAM1_HUMAN
NC score	0.062346 (rank : 1109)	θ value	θ > 10 (rank : 1367)
Query Neighborhood Hits	479	Target Neighborhood Hits	225	Shared Neighborhood Hits	29
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SEC20_MOUSE
NC score	0.062326 (rank : 1110)	θ value	θ > 10 (rank : 1256)
Query Neighborhood Hits	479	Target Neighborhood Hits	323	Shared Neighborhood Hits	116
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

STK39_HUMAN
NC score	0.062194 (rank : 1111)	θ value	θ > 10 (rank : 1324)
Query Neighborhood Hits	479	Target Neighborhood Hits	882	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

TTBK1_HUMAN
NC score	0.062162 (rank : 1112)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	479	Target Neighborhood Hits	1058	Shared Neighborhood Hits	72
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

ARHG8_HUMAN
NC score	0.062105 (rank : 1113)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	479	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

STK39_MOUSE
NC score	0.062093 (rank : 1114)	θ value	θ > 10 (rank : 1325)
Query Neighborhood Hits	479	Target Neighborhood Hits	915	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

U2AFM_MOUSE
NC score	0.062083 (rank : 1115)	θ value	θ > 10 (rank : 1423)
Query Neighborhood Hits	479	Target Neighborhood Hits	543	Shared Neighborhood Hits	140
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

ZRF1_HUMAN
NC score	0.061904 (rank : 1116)	θ value	θ > 10 (rank : 1455)
Query Neighborhood Hits	479	Target Neighborhood Hits	457	Shared Neighborhood Hits	116
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

CCD38_MOUSE
NC score	0.061849 (rank : 1117)	θ value	2.36792 (rank : 351)
Query Neighborhood Hits	479	Target Neighborhood Hits	165	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CDN8, Q8CDD6, Q8CDE1	Gene names	Ccdc38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

JIP3_HUMAN
NC score	0.061844 (rank : 1118)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	479	Target Neighborhood Hits	1039	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

GNRP_MOUSE
NC score	0.061808 (rank : 1119)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	479	Target Neighborhood Hits	191	Shared Neighborhood Hits	32
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MMRN2_HUMAN
NC score	0.061742 (rank : 1120)	θ value	θ > 10 (rank : 1034)
Query Neighborhood Hits	479	Target Neighborhood Hits	400	Shared Neighborhood Hits	116
SwissProt Accessions	Q9H8L6, Q6P2N2	Gene names	MMRN2, EMILIN3
Domain Architecture
Description	Multimerin-2 precursor (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit).

CLUA1_MOUSE
NC score	0.061671 (rank : 1121)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	479	Target Neighborhood Hits	261	Shared Neighborhood Hits	108
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

OXSR1_MOUSE
NC score	0.061583 (rank : 1122)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	479	Target Neighborhood Hits	865	Shared Neighborhood Hits	60
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

KIFC1_HUMAN
NC score	0.061576 (rank : 1123)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	479	Target Neighborhood Hits	545	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BW19, O60887, Q14834, Q9UQP7	Gene names	KIFC1, HSET, KNSL2
Domain Architecture
Description	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET).

LRRK1_MOUSE
NC score	0.061564 (rank : 1124)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	479	Target Neighborhood Hits	1267	Shared Neighborhood Hits	58
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LBN_HUMAN
NC score	0.061505 (rank : 1125)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	479	Target Neighborhood Hits	308	Shared Neighborhood Hits	113
SwissProt Accessions	Q86UK5, Q86YT3, Q86YT4, Q8NG49	Gene names	EVC2, LBN
Domain Architecture	No domain graphic available
Description	Limbin.

SHAN2_MOUSE
NC score	0.061450 (rank : 1126)	θ value	θ > 10 (rank : 1269)
Query Neighborhood Hits	479	Target Neighborhood Hits	446	Shared Neighborhood Hits	72
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

OXSR1_HUMAN
NC score	0.061412 (rank : 1127)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	58
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

JIP2_HUMAN
NC score	0.061404 (rank : 1128)	θ value	2.36792 (rank : 361)
Query Neighborhood Hits	479	Target Neighborhood Hits	288	Shared Neighborhood Hits	43
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

TNNT2_MOUSE
NC score	0.061399 (rank : 1129)	θ value	θ > 10 (rank : 1385)
Query Neighborhood Hits	479	Target Neighborhood Hits	395	Shared Neighborhood Hits	130
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

KIF11_HUMAN
NC score	0.061376 (rank : 1130)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	479	Target Neighborhood Hits	583	Shared Neighborhood Hits	166
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

LRRK1_HUMAN
NC score	0.061136 (rank : 1131)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	479	Target Neighborhood Hits	1237	Shared Neighborhood Hits	58
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

GBP1_HUMAN
NC score	0.061084 (rank : 1132)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	479	Target Neighborhood Hits	339	Shared Neighborhood Hits	119
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

KIF3A_HUMAN
NC score	0.061075 (rank : 1133)	θ value	8.99809 (rank : 462)
Query Neighborhood Hits	479	Target Neighborhood Hits	704	Shared Neighborhood Hits	173
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

BMPR2_HUMAN
NC score	0.061067 (rank : 1134)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	479	Target Neighborhood Hits	736	Shared Neighborhood Hits	61
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

STAT1_MOUSE
NC score	0.061057 (rank : 1135)	θ value	0.163984 (rank : 226)
Query Neighborhood Hits	479	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	P42225	Gene names	Stat1
Domain Architecture
Description	Signal transducer and activator of transcription 1.

BMPR2_MOUSE
NC score	0.061036 (rank : 1136)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	479	Target Neighborhood Hits	738	Shared Neighborhood Hits	62
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

STA5A_HUMAN
NC score	0.060995 (rank : 1137)	θ value	1.38821 (rank : 327)
Query Neighborhood Hits	479	Target Neighborhood Hits	140	Shared Neighborhood Hits	64
SwissProt Accessions	P42229	Gene names	STAT5A, STAT5
Domain Architecture
Description	Signal transducer and activator of transcription 5A.

DYHC_MOUSE
NC score	0.060928 (rank : 1138)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	479	Target Neighborhood Hits	729	Shared Neighborhood Hits	172
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_HUMAN
NC score	0.060793 (rank : 1139)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	479	Target Neighborhood Hits	733	Shared Neighborhood Hits	170
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

LRRK2_HUMAN
NC score	0.060583 (rank : 1140)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	479	Target Neighborhood Hits	1382	Shared Neighborhood Hits	63
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

GAS7_HUMAN
NC score	0.060570 (rank : 1141)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	479	Target Neighborhood Hits	258	Shared Neighborhood Hits	89
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SDPR_MOUSE
NC score	0.060537 (rank : 1142)	θ value	θ > 10 (rank : 1255)
Query Neighborhood Hits	479	Target Neighborhood Hits	485	Shared Neighborhood Hits	106
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

TLK2_MOUSE
NC score	0.060520 (rank : 1143)	θ value	θ > 10 (rank : 1376)
Query Neighborhood Hits	479	Target Neighborhood Hits	1088	Shared Neighborhood Hits	165
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

CENPH_MOUSE
NC score	0.060464 (rank : 1144)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	479	Target Neighborhood Hits	195	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

KPCD3_HUMAN
NC score	0.060433 (rank : 1145)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	75
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCG_MOUSE
NC score	0.060238 (rank : 1146)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	479	Target Neighborhood Hits	1123	Shared Neighborhood Hits	81
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCD2_HUMAN
NC score	0.060161 (rank : 1147)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	479	Target Neighborhood Hits	910	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCG_HUMAN
NC score	0.060130 (rank : 1148)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	479	Target Neighborhood Hits	1126	Shared Neighborhood Hits	81
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCE_MOUSE
NC score	0.060092 (rank : 1149)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	73
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCD3_MOUSE
NC score	0.060001 (rank : 1150)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	479	Target Neighborhood Hits	901	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

LRRK2_MOUSE
NC score	0.059987 (rank : 1151)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	479	Target Neighborhood Hits	1359	Shared Neighborhood Hits	64
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

JIP3_MOUSE
NC score	0.059937 (rank : 1152)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	479	Target Neighborhood Hits	759	Shared Neighborhood Hits	175
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

KPCE_HUMAN
NC score	0.059758 (rank : 1153)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	73
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

GFAP_HUMAN
NC score	0.059697 (rank : 1154)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	479	Target Neighborhood Hits	723	Shared Neighborhood Hits	188
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

STK24_MOUSE
NC score	0.059623 (rank : 1155)	θ value	θ > 10 (rank : 1321)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	58
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

AMOL1_MOUSE
NC score	0.059620 (rank : 1156)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	479	Target Neighborhood Hits	445	Shared Neighborhood Hits	118
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

GAS7_MOUSE
NC score	0.059612 (rank : 1157)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	479	Target Neighborhood Hits	259	Shared Neighborhood Hits	90
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

ARHG8_MOUSE
NC score	0.059576 (rank : 1158)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	479	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

KPCD1_HUMAN
NC score	0.059567 (rank : 1159)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	479	Target Neighborhood Hits	901	Shared Neighborhood Hits	75
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

STA5A_MOUSE
NC score	0.059567 (rank : 1160)	θ value	1.38821 (rank : 328)
Query Neighborhood Hits	479	Target Neighborhood Hits	128	Shared Neighborhood Hits	60
SwissProt Accessions	P42230	Gene names	Stat5a, Mgf, Mpf
Domain Architecture
Description	Signal transducer and activator of transcription 5A (Mammary gland factor).

LETM1_MOUSE
NC score	0.059484 (rank : 1161)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	479	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

SKI_MOUSE
NC score	0.059481 (rank : 1162)	θ value	θ > 10 (rank : 1276)
Query Neighborhood Hits	479	Target Neighborhood Hits	423	Shared Neighborhood Hits	125
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

LMO7_HUMAN
NC score	0.059410 (rank : 1163)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	479	Target Neighborhood Hits	507	Shared Neighborhood Hits	100
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

YO11_MOUSE
NC score	0.059376 (rank : 1164)	θ value	θ > 10 (rank : 1452)
Query Neighborhood Hits	479	Target Neighborhood Hits	272	Shared Neighborhood Hits	91
SwissProt Accessions	P11260	Gene names
Domain Architecture
Description	Hypothetical protein ORF-1137.

STK24_HUMAN
NC score	0.059227 (rank : 1165)	θ value	θ > 10 (rank : 1320)
Query Neighborhood Hits	479	Target Neighborhood Hits	853	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

MST4_HUMAN
NC score	0.059128 (rank : 1166)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	479	Target Neighborhood Hits	852	Shared Neighborhood Hits	58
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK16_MOUSE
NC score	0.059095 (rank : 1167)	θ value	θ > 10 (rank : 1319)
Query Neighborhood Hits	479	Target Neighborhood Hits	824	Shared Neighborhood Hits	58
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

CROP_HUMAN
NC score	0.059052 (rank : 1168)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	479	Target Neighborhood Hits	402	Shared Neighborhood Hits	107
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

MST4_MOUSE
NC score	0.059009 (rank : 1169)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	479	Target Neighborhood Hits	860	Shared Neighborhood Hits	58
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

NOXO1_HUMAN
NC score	0.058933 (rank : 1170)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	479	Target Neighborhood Hits	100	Shared Neighborhood Hits	42
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

STAT1_HUMAN
NC score	0.058916 (rank : 1171)	θ value	0.47712 (rank : 271)
Query Neighborhood Hits	479	Target Neighborhood Hits	128	Shared Neighborhood Hits	59
SwissProt Accessions	P42224	Gene names	STAT1
Domain Architecture
Description	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84).

CLC4F_MOUSE
NC score	0.058877 (rank : 1172)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	479	Target Neighborhood Hits	572	Shared Neighborhood Hits	135
SwissProt Accessions	P70194, Q8BLZ8	Gene names	Clec4f, Clecsf13, Kclr
Domain Architecture
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor).

KIF3B_HUMAN
NC score	0.058818 (rank : 1173)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	479	Target Neighborhood Hits	540	Shared Neighborhood Hits	161
SwissProt Accessions	O15066	Gene names	KIF3B, KIAA0359
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) (HH0048).

KPCD1_MOUSE
NC score	0.058800 (rank : 1174)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	479	Target Neighborhood Hits	891	Shared Neighborhood Hits	75
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

FA50A_MOUSE
NC score	0.058781 (rank : 1175)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	479	Target Neighborhood Hits	293	Shared Neighborhood Hits	111
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

KI21B_MOUSE
NC score	0.058749 (rank : 1176)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	479	Target Neighborhood Hits	997	Shared Neighborhood Hits	195
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

PRC1_HUMAN
NC score	0.058585 (rank : 1177)	θ value	θ > 10 (rank : 1185)
Query Neighborhood Hits	479	Target Neighborhood Hits	328	Shared Neighborhood Hits	115
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

KIF23_HUMAN
NC score	0.058562 (rank : 1178)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	479	Target Neighborhood Hits	618	Shared Neighborhood Hits	163
SwissProt Accessions	Q02241	Gene names	KIF23, KNSL5, MKLP1
Domain Architecture
Description	Kinesin-like protein KIF23 (Mitotic kinesin-like protein 1) (Kinesin- like protein 5).

STK16_HUMAN
NC score	0.058435 (rank : 1179)	θ value	θ > 10 (rank : 1318)
Query Neighborhood Hits	479	Target Neighborhood Hits	824	Shared Neighborhood Hits	58
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STXB4_MOUSE
NC score	0.058420 (rank : 1180)	θ value	θ > 10 (rank : 1332)
Query Neighborhood Hits	479	Target Neighborhood Hits	629	Shared Neighborhood Hits	150
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MAP1B_MOUSE
NC score	0.058272 (rank : 1181)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	479	Target Neighborhood Hits	977	Shared Neighborhood Hits	135
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

TRDN_HUMAN
NC score	0.058235 (rank : 1182)	θ value	θ > 10 (rank : 1401)
Query Neighborhood Hits	479	Target Neighborhood Hits	542	Shared Neighborhood Hits	103
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

STK25_MOUSE
NC score	0.058132 (rank : 1183)	θ value	θ > 10 (rank : 1323)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

SKI_HUMAN
NC score	0.058091 (rank : 1184)	θ value	θ > 10 (rank : 1275)
Query Neighborhood Hits	479	Target Neighborhood Hits	423	Shared Neighborhood Hits	124
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

IMMT_MOUSE
NC score	0.058045 (rank : 1185)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	479	Target Neighborhood Hits	326	Shared Neighborhood Hits	114
SwissProt Accessions	Q8CAQ8, Q66JS4, Q7TNE2, Q8C7V1, Q8CCI0, Q8CDA8, Q9D9F6	Gene names	Immt
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin).

KIFC3_MOUSE
NC score	0.057999 (rank : 1186)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	479	Target Neighborhood Hits	571	Shared Neighborhood Hits	158
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KI21B_HUMAN
NC score	0.057999 (rank : 1187)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	479	Target Neighborhood Hits	1017	Shared Neighborhood Hits	193
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

HAP1_MOUSE
NC score	0.057969 (rank : 1188)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	479	Target Neighborhood Hits	388	Shared Neighborhood Hits	108
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

K0494_HUMAN
NC score	0.057954 (rank : 1189)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	479	Target Neighborhood Hits	230	Shared Neighborhood Hits	81
SwissProt Accessions	O75071	Gene names	KIAA0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

NEK1_MOUSE
NC score	0.057950 (rank : 1190)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	479	Target Neighborhood Hits	1311	Shared Neighborhood Hits	143
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

STK25_HUMAN
NC score	0.057849 (rank : 1191)	θ value	θ > 10 (rank : 1322)
Query Neighborhood Hits	479	Target Neighborhood Hits	853	Shared Neighborhood Hits	58
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

GFAP_MOUSE
NC score	0.057793 (rank : 1192)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	479	Target Neighborhood Hits	725	Shared Neighborhood Hits	191
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

K2C1_HUMAN
NC score	0.057779 (rank : 1193)	θ value	8.99809 (rank : 460)
Query Neighborhood Hits	479	Target Neighborhood Hits	624	Shared Neighborhood Hits	165
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

NTBP1_MOUSE
NC score	0.057712 (rank : 1194)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	479	Target Neighborhood Hits	528	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

CD2L1_MOUSE
NC score	0.057553 (rank : 1195)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	479	Target Neighborhood Hits	1463	Shared Neighborhood Hits	173
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

TNNT3_MOUSE
NC score	0.057512 (rank : 1196)	θ value	θ > 10 (rank : 1387)
Query Neighborhood Hits	479	Target Neighborhood Hits	317	Shared Neighborhood Hits	103
SwissProt Accessions	Q9QZ47, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46	Gene names	Tnnt3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT).

LRSM1_MOUSE
NC score	0.057511 (rank : 1197)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	153
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

CDC37_MOUSE
NC score	0.057360 (rank : 1198)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	479	Target Neighborhood Hits	359	Shared Neighborhood Hits	119
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

MYLK2_HUMAN
NC score	0.057342 (rank : 1199)	θ value	θ > 10 (rank : 1069)
Query Neighborhood Hits	479	Target Neighborhood Hits	920	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

STA5B_MOUSE
NC score	0.057320 (rank : 1200)	θ value	3.0926 (rank : 390)
Query Neighborhood Hits	479	Target Neighborhood Hits	124	Shared Neighborhood Hits	62
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

YSK4_HUMAN
NC score	0.057244 (rank : 1201)	θ value	θ > 10 (rank : 1453)
Query Neighborhood Hits	479	Target Neighborhood Hits	921	Shared Neighborhood Hits	64
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CD2L1_HUMAN
NC score	0.057169 (rank : 1202)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	479	Target Neighborhood Hits	1467	Shared Neighborhood Hits	169
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

IKKB_HUMAN
NC score	0.057110 (rank : 1203)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	479	Target Neighborhood Hits	980	Shared Neighborhood Hits	110
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KIF3A_MOUSE
NC score	0.057028 (rank : 1204)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	479	Target Neighborhood Hits	715	Shared Neighborhood Hits	170
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

MP2K2_MOUSE
NC score	0.056939 (rank : 1205)	θ value	θ > 10 (rank : 1041)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	58
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

NEK6_MOUSE
NC score	0.056936 (rank : 1206)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

E2AK2_MOUSE
NC score	0.056870 (rank : 1207)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	479	Target Neighborhood Hits	864	Shared Neighborhood Hits	60
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

STA5B_HUMAN
NC score	0.056807 (rank : 1208)	θ value	3.0926 (rank : 389)
Query Neighborhood Hits	479	Target Neighborhood Hits	103	Shared Neighborhood Hits	57
SwissProt Accessions	P51692, Q8WWS8	Gene names	STAT5B
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

MP2K2_HUMAN
NC score	0.056807 (rank : 1209)	θ value	θ > 10 (rank : 1040)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	59
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

SPTN5_HUMAN
NC score	0.056752 (rank : 1210)	θ value	θ > 10 (rank : 1302)
Query Neighborhood Hits	479	Target Neighborhood Hits	674	Shared Neighborhood Hits	163
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

NEK6_HUMAN
NC score	0.056688 (rank : 1211)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

CUTL2_HUMAN
NC score	0.056616 (rank : 1212)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	479	Target Neighborhood Hits	906	Shared Neighborhood Hits	134
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

BAP29_HUMAN
NC score	0.056556 (rank : 1213)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	479	Target Neighborhood Hits	362	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UHQ4, O95003	Gene names	BCAP29, BAP29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

CCD22_HUMAN
NC score	0.056544 (rank : 1214)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	479	Target Neighborhood Hits	242	Shared Neighborhood Hits	97
SwissProt Accessions	O60826	Gene names	CCDC22, CXorf37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CROP_MOUSE
NC score	0.056533 (rank : 1215)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	479	Target Neighborhood Hits	403	Shared Neighborhood Hits	106
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

HAPIP_HUMAN
NC score	0.056495 (rank : 1216)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	479	Target Neighborhood Hits	350	Shared Neighborhood Hits	115
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

SPC25_HUMAN
NC score	0.056472 (rank : 1217)	θ value	θ > 10 (rank : 1292)
Query Neighborhood Hits	479	Target Neighborhood Hits	273	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

CYLC1_HUMAN
NC score	0.056451 (rank : 1218)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	479	Target Neighborhood Hits	408	Shared Neighborhood Hits	75
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

A20A4_HUMAN
NC score	0.056442 (rank : 1219)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	479	Target Neighborhood Hits	710	Shared Neighborhood Hits	152
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

DUET_HUMAN
NC score	0.056433 (rank : 1220)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	479	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MP2K7_HUMAN
NC score	0.056362 (rank : 1221)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	58
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

NGAP_HUMAN
NC score	0.056353 (rank : 1222)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	479	Target Neighborhood Hits	517	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

NEK7_HUMAN
NC score	0.056351 (rank : 1223)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	479	Target Neighborhood Hits	846	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

TAF7_HUMAN
NC score	0.056343 (rank : 1224)	θ value	θ > 10 (rank : 1344)
Query Neighborhood Hits	479	Target Neighborhood Hits	222	Shared Neighborhood Hits	92
SwissProt Accessions	Q15545, Q13036	Gene names	TAF7, TAF2F, TAFII55
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

NEB1_HUMAN
NC score	0.056318 (rank : 1225)	θ value	θ > 10 (rank : 1101)
Query Neighborhood Hits	479	Target Neighborhood Hits	829	Shared Neighborhood Hits	149
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NEK1_HUMAN
NC score	0.056317 (rank : 1226)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	479	Target Neighborhood Hits	1129	Shared Neighborhood Hits	123
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK7_MOUSE
NC score	0.056309 (rank : 1227)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	479	Target Neighborhood Hits	847	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

TLK2_HUMAN
NC score	0.056211 (rank : 1228)	θ value	θ > 10 (rank : 1375)
Query Neighborhood Hits	479	Target Neighborhood Hits	1044	Shared Neighborhood Hits	138
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

JIP1_MOUSE
NC score	0.056060 (rank : 1229)	θ value	2.36792 (rank : 360)
Query Neighborhood Hits	479	Target Neighborhood Hits	259	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_HUMAN
NC score	0.056036 (rank : 1230)	θ value	2.36792 (rank : 359)
Query Neighborhood Hits	479	Target Neighborhood Hits	271	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARHG1_HUMAN
NC score	0.056009 (rank : 1231)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	479	Target Neighborhood Hits	176	Shared Neighborhood Hits	25
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

MP2K5_MOUSE
NC score	0.055972 (rank : 1232)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	479	Target Neighborhood Hits	840	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

CENPK_HUMAN
NC score	0.055791 (rank : 1233)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	479	Target Neighborhood Hits	273	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BS16, Q9H4L0	Gene names	CENPK, ICEN37
Domain Architecture	No domain graphic available
Description	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33).

TBK1_MOUSE
NC score	0.055780 (rank : 1234)	θ value	θ > 10 (rank : 1353)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

NUP88_HUMAN
NC score	0.055775 (rank : 1235)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	479	Target Neighborhood Hits	354	Shared Neighborhood Hits	118
SwissProt Accessions	Q99567, Q9BWE5	Gene names	NUP88
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup88 (Nucleoporin Nup88) (88 kDa nuclear pore complex protein).

NEK2_HUMAN
NC score	0.055610 (rank : 1236)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	479	Target Neighborhood Hits	908	Shared Neighborhood Hits	91
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

CASC5_HUMAN
NC score	0.055583 (rank : 1237)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	479	Target Neighborhood Hits	376	Shared Neighborhood Hits	127
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

IKKB_MOUSE
NC score	0.055570 (rank : 1238)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	479	Target Neighborhood Hits	984	Shared Neighborhood Hits	110
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

LAMA4_HUMAN
NC score	0.055500 (rank : 1239)	θ value	1.81305 (rank : 341)
Query Neighborhood Hits	479	Target Neighborhood Hits	708	Shared Neighborhood Hits	138
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

ULK1_MOUSE
NC score	0.055428 (rank : 1240)	θ value	θ > 10 (rank : 1427)
Query Neighborhood Hits	479	Target Neighborhood Hits	1214	Shared Neighborhood Hits	77
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

NEK4_MOUSE
NC score	0.055334 (rank : 1241)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	479	Target Neighborhood Hits	899	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

KPCL_MOUSE
NC score	0.055324 (rank : 1242)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	479	Target Neighborhood Hits	891	Shared Neighborhood Hits	73
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

K2C6B_HUMAN
NC score	0.055277 (rank : 1243)	θ value	2.36792 (rank : 366)
Query Neighborhood Hits	479	Target Neighborhood Hits	526	Shared Neighborhood Hits	157
SwissProt Accessions	P04259, P48669	Gene names	KRT6B, K6B
Domain Architecture
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin).

K0494_MOUSE
NC score	0.055238 (rank : 1244)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	479	Target Neighborhood Hits	241	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BGQ6, Q3TQN6, Q8BJV7, Q8C0R1	Gene names	Kiaa0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

IKKA_HUMAN
NC score	0.055194 (rank : 1245)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	479	Target Neighborhood Hits	863	Shared Neighborhood Hits	63
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

AVR2A_MOUSE
NC score	0.055183 (rank : 1246)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	479	Target Neighborhood Hits	767	Shared Neighborhood Hits	58
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.055182 (rank : 1247)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	479	Target Neighborhood Hits	767	Shared Neighborhood Hits	58
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

K2C6E_HUMAN
NC score	0.055174 (rank : 1248)	θ value	2.36792 (rank : 368)
Query Neighborhood Hits	479	Target Neighborhood Hits	516	Shared Neighborhood Hits	153
SwissProt Accessions	P48668, Q7RTN9	Gene names	KRT6E
Domain Architecture
Description	Keratin, type II cytoskeletal 6E (Cytokeratin-6E) (CK 6E) (K6e keratin) (Keratin K6h).

MP2K1_MOUSE
NC score	0.055141 (rank : 1249)	θ value	θ > 10 (rank : 1039)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

WNK2_HUMAN
NC score	0.055141 (rank : 1250)	θ value	θ > 10 (rank : 1448)
Query Neighborhood Hits	479	Target Neighborhood Hits	1407	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

IKKA_MOUSE
NC score	0.055114 (rank : 1251)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	68
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

LBN_MOUSE
NC score	0.055094 (rank : 1252)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	479	Target Neighborhood Hits	310	Shared Neighborhood Hits	113
SwissProt Accessions	Q8K1G2, Q8BRF3	Gene names	Evc2, Lbn
Domain Architecture	No domain graphic available
Description	Limbin.

AVR2B_MOUSE
NC score	0.055054 (rank : 1253)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	479	Target Neighborhood Hits	749	Shared Neighborhood Hits	59
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

NEK3_HUMAN
NC score	0.055025 (rank : 1254)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	479	Target Neighborhood Hits	865	Shared Neighborhood Hits	62
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

MP2K1_HUMAN
NC score	0.055013 (rank : 1255)	θ value	θ > 10 (rank : 1038)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

CD2L2_HUMAN
NC score	0.054960 (rank : 1256)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	479	Target Neighborhood Hits	1439	Shared Neighborhood Hits	162
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

AVR2B_HUMAN
NC score	0.054951 (rank : 1257)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	59
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

NEK4_HUMAN
NC score	0.054938 (rank : 1258)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	479	Target Neighborhood Hits	883	Shared Neighborhood Hits	61
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

SURF6_MOUSE
NC score	0.054931 (rank : 1259)	θ value	θ > 10 (rank : 1335)
Query Neighborhood Hits	479	Target Neighborhood Hits	195	Shared Neighborhood Hits	71
SwissProt Accessions	P70279, Q8BPI4, Q8BRL7, Q8R0Q7	Gene names	Surf6, Surf-6
Domain Architecture
Description	Surfeit locus protein 6.

APOE_MOUSE
NC score	0.054922 (rank : 1260)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	479	Target Neighborhood Hits	319	Shared Neighborhood Hits	104
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

KPCL_HUMAN
NC score	0.054876 (rank : 1261)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	479	Target Neighborhood Hits	887	Shared Neighborhood Hits	73
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

RILP_MOUSE
NC score	0.054817 (rank : 1262)	θ value	θ > 10 (rank : 1212)
Query Neighborhood Hits	479	Target Neighborhood Hits	257	Shared Neighborhood Hits	87
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

SBK1_MOUSE
NC score	0.054751 (rank : 1263)	θ value	θ > 10 (rank : 1251)
Query Neighborhood Hits	479	Target Neighborhood Hits	824	Shared Neighborhood Hits	58
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

GLE1_HUMAN
NC score	0.054727 (rank : 1264)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	479	Target Neighborhood Hits	445	Shared Neighborhood Hits	114
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

PAWR_HUMAN
NC score	0.054700 (rank : 1265)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	479	Target Neighborhood Hits	252	Shared Neighborhood Hits	79
SwissProt Accessions	Q96IZ0, O75796, Q6FHY9, Q8N700	Gene names	PAWR, PAR4
Domain Architecture	No domain graphic available
Description	PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4).

SBK1_HUMAN
NC score	0.054689 (rank : 1266)	θ value	θ > 10 (rank : 1250)
Query Neighborhood Hits	479	Target Neighborhood Hits	828	Shared Neighborhood Hits	59
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

WDR67_MOUSE
NC score	0.054687 (rank : 1267)	θ value	θ > 10 (rank : 1445)
Query Neighborhood Hits	479	Target Neighborhood Hits	476	Shared Neighborhood Hits	119
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

MCF2_HUMAN
NC score	0.054662 (rank : 1268)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	479	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MP2K4_HUMAN
NC score	0.054608 (rank : 1269)	θ value	θ > 10 (rank : 1044)
Query Neighborhood Hits	479	Target Neighborhood Hits	832	Shared Neighborhood Hits	58
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

CM007_HUMAN
NC score	0.054563 (rank : 1270)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	479	Target Neighborhood Hits	422	Shared Neighborhood Hits	108
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

SN1L2_MOUSE
NC score	0.054538 (rank : 1271)	θ value	θ > 10 (rank : 1286)
Query Neighborhood Hits	479	Target Neighborhood Hits	944	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MP2K4_MOUSE
NC score	0.054504 (rank : 1272)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	58
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

STK3_HUMAN
NC score	0.054483 (rank : 1273)	θ value	θ > 10 (rank : 1326)
Query Neighborhood Hits	479	Target Neighborhood Hits	861	Shared Neighborhood Hits	62
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

SN1L2_HUMAN
NC score	0.054468 (rank : 1274)	θ value	θ > 10 (rank : 1285)
Query Neighborhood Hits	479	Target Neighborhood Hits	964	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SPTB1_MOUSE
NC score	0.054462 (rank : 1275)	θ value	θ > 10 (rank : 1299)
Query Neighborhood Hits	479	Target Neighborhood Hits	543	Shared Neighborhood Hits	153
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

ICK_MOUSE
NC score	0.054373 (rank : 1276)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	479	Target Neighborhood Hits	860	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

STK3_MOUSE
NC score	0.054365 (rank : 1277)	θ value	θ > 10 (rank : 1327)
Query Neighborhood Hits	479	Target Neighborhood Hits	869	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

TBK1_HUMAN
NC score	0.054360 (rank : 1278)	θ value	θ > 10 (rank : 1352)
Query Neighborhood Hits	479	Target Neighborhood Hits	861	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

RNF8_HUMAN
NC score	0.054335 (rank : 1279)	θ value	θ > 10 (rank : 1226)
Query Neighborhood Hits	479	Target Neighborhood Hits	622	Shared Neighborhood Hits	137
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

MAK_MOUSE
NC score	0.054310 (rank : 1280)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	479	Target Neighborhood Hits	873	Shared Neighborhood Hits	59
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

NOP14_HUMAN
NC score	0.054245 (rank : 1281)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	479	Target Neighborhood Hits	573	Shared Neighborhood Hits	121
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

ICK_HUMAN
NC score	0.054219 (rank : 1282)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	479	Target Neighborhood Hits	867	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

TSSK4_HUMAN
NC score	0.054198 (rank : 1283)	θ value	θ > 10 (rank : 1406)
Query Neighborhood Hits	479	Target Neighborhood Hits	836	Shared Neighborhood Hits	58
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

MP2K3_MOUSE
NC score	0.054189 (rank : 1284)	θ value	θ > 10 (rank : 1043)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

STK4_HUMAN
NC score	0.054136 (rank : 1285)	θ value	θ > 10 (rank : 1328)
Query Neighborhood Hits	479	Target Neighborhood Hits	870	Shared Neighborhood Hits	61
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

MP2K5_HUMAN
NC score	0.054059 (rank : 1286)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	479	Target Neighborhood Hits	837	Shared Neighborhood Hits	60
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

STK4_MOUSE
NC score	0.054053 (rank : 1287)	θ value	θ > 10 (rank : 1329)
Query Neighborhood Hits	479	Target Neighborhood Hits	873	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

TS101_MOUSE
NC score	0.054048 (rank : 1288)	θ value	8.99809 (rank : 479)
Query Neighborhood Hits	479	Target Neighborhood Hits	312	Shared Neighborhood Hits	103
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

MP2K6_MOUSE
NC score	0.054046 (rank : 1289)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	58
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_HUMAN
NC score	0.053968 (rank : 1290)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	58
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NEK3_MOUSE
NC score	0.053927 (rank : 1291)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	479	Target Neighborhood Hits	854	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

ULK2_MOUSE
NC score	0.053869 (rank : 1292)	θ value	θ > 10 (rank : 1429)
Query Neighborhood Hits	479	Target Neighborhood Hits	943	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KIFC3_HUMAN
NC score	0.053681 (rank : 1293)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	479	Target Neighborhood Hits	619	Shared Neighborhood Hits	172
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

MP2K3_HUMAN
NC score	0.053657 (rank : 1294)	θ value	θ > 10 (rank : 1042)
Query Neighborhood Hits	479	Target Neighborhood Hits	825	Shared Neighborhood Hits	58
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

WNK3_HUMAN
NC score	0.053647 (rank : 1295)	θ value	θ > 10 (rank : 1449)
Query Neighborhood Hits	479	Target Neighborhood Hits	948	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

ULK2_HUMAN
NC score	0.053645 (rank : 1296)	θ value	θ > 10 (rank : 1428)
Query Neighborhood Hits	479	Target Neighborhood Hits	979	Shared Neighborhood Hits	61
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

MYO15_MOUSE
NC score	0.053608 (rank : 1297)	θ value	θ > 10 (rank : 1072)
Query Neighborhood Hits	479	Target Neighborhood Hits	467	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ULK1_HUMAN
NC score	0.053565 (rank : 1298)	θ value	θ > 10 (rank : 1426)
Query Neighborhood Hits	479	Target Neighborhood Hits	1121	Shared Neighborhood Hits	67
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

MAK_HUMAN
NC score	0.053561 (rank : 1299)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	479	Target Neighborhood Hits	857	Shared Neighborhood Hits	60
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

BRSK2_HUMAN
NC score	0.053358 (rank : 1300)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	479	Target Neighborhood Hits	897	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

NEK2_MOUSE
NC score	0.053339 (rank : 1301)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	479	Target Neighborhood Hits	876	Shared Neighborhood Hits	73
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

LAMA3_HUMAN
NC score	0.053329 (rank : 1302)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	479	Target Neighborhood Hits	760	Shared Neighborhood Hits	143
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

CTTB2_HUMAN
NC score	0.053315 (rank : 1303)	θ value	8.99809 (rank : 456)
Query Neighborhood Hits	479	Target Neighborhood Hits	1061	Shared Neighborhood Hits	183
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

TARA_HUMAN
NC score	0.053305 (rank : 1304)	θ value	θ > 10 (rank : 1349)
Query Neighborhood Hits	479	Target Neighborhood Hits	1626	Shared Neighborhood Hits	175
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

KC1D_HUMAN
NC score	0.053303 (rank : 1305)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	479	Target Neighborhood Hits	737	Shared Neighborhood Hits	57
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.053298 (rank : 1306)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	479	Target Neighborhood Hits	737	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

AL2S2_MOUSE
NC score	0.053284 (rank : 1307)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	479	Target Neighborhood Hits	709	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

A20A1_HUMAN
NC score	0.053276 (rank : 1308)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	479	Target Neighborhood Hits	698	Shared Neighborhood Hits	145
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

TSSK4_MOUSE
NC score	0.053179 (rank : 1309)	θ value	θ > 10 (rank : 1407)
Query Neighborhood Hits	479	Target Neighborhood Hits	840	Shared Neighborhood Hits	58
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

SHLB2_MOUSE
NC score	0.053140 (rank : 1310)	θ value	θ > 10 (rank : 1272)
Query Neighborhood Hits	479	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

IDLC_HUMAN
NC score	0.053125 (rank : 1311)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	479	Target Neighborhood Hits	348	Shared Neighborhood Hits	107
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

E2AK2_HUMAN
NC score	0.053086 (rank : 1312)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	479	Target Neighborhood Hits	856	Shared Neighborhood Hits	63
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

WTAP_HUMAN
NC score	0.053050 (rank : 1313)	θ value	θ > 10 (rank : 1450)
Query Neighborhood Hits	479	Target Neighborhood Hits	262	Shared Neighborhood Hits	92
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

K2C6C_HUMAN
NC score	0.053018 (rank : 1314)	θ value	2.36792 (rank : 367)
Query Neighborhood Hits	479	Target Neighborhood Hits	503	Shared Neighborhood Hits	151
SwissProt Accessions	P48666	Gene names	KRT6C
Domain Architecture
Description	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK 6C) (K6c keratin).

WNK1_HUMAN
NC score	0.053003 (rank : 1315)	θ value	θ > 10 (rank : 1446)
Query Neighborhood Hits	479	Target Neighborhood Hits	1158	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

A20A3_HUMAN
NC score	0.052948 (rank : 1316)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	479	Target Neighborhood Hits	692	Shared Neighborhood Hits	149
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

SPC25_MOUSE
NC score	0.052938 (rank : 1317)	θ value	θ > 10 (rank : 1293)
Query Neighborhood Hits	479	Target Neighborhood Hits	241	Shared Neighborhood Hits	93
SwissProt Accessions	Q3UA16, Q9D021, Q9D1K6	Gene names	Spbc25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25.

NUAK1_MOUSE
NC score	0.052899 (rank : 1318)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	479	Target Neighborhood Hits	881	Shared Neighborhood Hits	64
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

K2C6A_HUMAN
NC score	0.052877 (rank : 1319)	θ value	2.36792 (rank : 365)
Query Neighborhood Hits	479	Target Neighborhood Hits	505	Shared Neighborhood Hits	151
SwissProt Accessions	P02538, Q6NT67, Q96CL4	Gene names	KRT6A, K6A
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin).

CD2L7_HUMAN
NC score	0.052846 (rank : 1320)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	479	Target Neighborhood Hits	1275	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

ARHG1_MOUSE
NC score	0.052819 (rank : 1321)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	479	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

WNK1_MOUSE
NC score	0.052782 (rank : 1322)	θ value	θ > 10 (rank : 1447)
Query Neighborhood Hits	479	Target Neighborhood Hits	1179	Shared Neighborhood Hits	72
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

IKKE_MOUSE
NC score	0.052729 (rank : 1323)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	479	Target Neighborhood Hits	848	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KGP2_HUMAN
NC score	0.052708 (rank : 1324)	θ value	0.279714 (rank : 240)
Query Neighborhood Hits	479	Target Neighborhood Hits	1023	Shared Neighborhood Hits	107
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

DIAP1_MOUSE
NC score	0.052678 (rank : 1325)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	479	Target Neighborhood Hits	839	Shared Neighborhood Hits	162
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

AL2S7_HUMAN
NC score	0.052609 (rank : 1326)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	479	Target Neighborhood Hits	831	Shared Neighborhood Hits	58
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

FA50A_HUMAN
NC score	0.052550 (rank : 1327)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	479	Target Neighborhood Hits	264	Shared Neighborhood Hits	100
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

TSSK1_MOUSE
NC score	0.052542 (rank : 1328)	θ value	θ > 10 (rank : 1404)
Query Neighborhood Hits	479	Target Neighborhood Hits	835	Shared Neighborhood Hits	60
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

DOCK1_HUMAN
NC score	0.052442 (rank : 1329)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	479	Target Neighborhood Hits	191	Shared Neighborhood Hits	84
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

CCAR1_HUMAN
NC score	0.052410 (rank : 1330)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	479	Target Neighborhood Hits	444	Shared Neighborhood Hits	123
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

MYO15_HUMAN
NC score	0.052274 (rank : 1331)	θ value	θ > 10 (rank : 1071)
Query Neighborhood Hits	479	Target Neighborhood Hits	671	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

K2C8_HUMAN
NC score	0.052257 (rank : 1332)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	479	Target Neighborhood Hits	593	Shared Neighborhood Hits	167
SwissProt Accessions	P05787, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q96J60	Gene names	KRT8, CYK8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8).

NUAK1_HUMAN
NC score	0.052245 (rank : 1333)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	59
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

MARK4_MOUSE
NC score	0.052148 (rank : 1334)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	479	Target Neighborhood Hits	898	Shared Neighborhood Hits	60
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MARK4_HUMAN
NC score	0.052137 (rank : 1335)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	60
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

BRSK1_HUMAN
NC score	0.052014 (rank : 1336)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	479	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

E2AK1_HUMAN
NC score	0.052011 (rank : 1337)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	479	Target Neighborhood Hits	833	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CCD37_MOUSE
NC score	0.051994 (rank : 1338)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	479	Target Neighborhood Hits	199	Shared Neighborhood Hits	76
SwissProt Accessions	Q80VN0, Q6AXD6	Gene names	Ccdc37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

KPCI_HUMAN
NC score	0.051914 (rank : 1339)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	479	Target Neighborhood Hits	885	Shared Neighborhood Hits	75
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

SN1L1_MOUSE
NC score	0.051892 (rank : 1340)	θ value	θ > 10 (rank : 1284)
Query Neighborhood Hits	479	Target Neighborhood Hits	895	Shared Neighborhood Hits	60
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

CD2L5_HUMAN
NC score	0.051886 (rank : 1341)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	479	Target Neighborhood Hits	987	Shared Neighborhood Hits	63
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

PKN2_HUMAN
NC score	0.051878 (rank : 1342)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	479	Target Neighborhood Hits	892	Shared Neighborhood Hits	86
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

BEGIN_HUMAN
NC score	0.051876 (rank : 1343)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	479	Target Neighborhood Hits	454	Shared Neighborhood Hits	125
SwissProt Accessions	Q9BUH8, Q9NPU3, Q9P282	Gene names	BEGAIN, KIAA1446
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

TGFR2_HUMAN
NC score	0.051841 (rank : 1344)	θ value	θ > 10 (rank : 1365)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	58
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
NC score	0.051835 (rank : 1345)	θ value	θ > 10 (rank : 1366)
Query Neighborhood Hits	479	Target Neighborhood Hits	748	Shared Neighborhood Hits	58
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

MARK3_HUMAN
NC score	0.051833 (rank : 1346)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	479	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

CD2L5_MOUSE
NC score	0.051823 (rank : 1347)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	479	Target Neighborhood Hits	1011	Shared Neighborhood Hits	62
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

KPCI_MOUSE
NC score	0.051786 (rank : 1348)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	75
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MARK3_MOUSE
NC score	0.051721 (rank : 1349)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	479	Target Neighborhood Hits	919	Shared Neighborhood Hits	59
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MASTL_MOUSE
NC score	0.051717 (rank : 1350)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	479	Target Neighborhood Hits	862	Shared Neighborhood Hits	60
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

K2C8_MOUSE
NC score	0.051717 (rank : 1351)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	479	Target Neighborhood Hits	576	Shared Neighborhood Hits	159
SwissProt Accessions	P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519	Gene names	Krt8, Krt2-8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Cytokeratin endo A).

PKN2_MOUSE
NC score	0.051669 (rank : 1352)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	479	Target Neighborhood Hits	899	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

MARK2_HUMAN
NC score	0.051663 (rank : 1353)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	479	Target Neighborhood Hits	1056	Shared Neighborhood Hits	69
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

E2AK3_HUMAN
NC score	0.051652 (rank : 1354)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	479	Target Neighborhood Hits	859	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

TEKT2_MOUSE
NC score	0.051615 (rank : 1355)	θ value	θ > 10 (rank : 1356)
Query Neighborhood Hits	479	Target Neighborhood Hits	199	Shared Neighborhood Hits	91
SwissProt Accessions	Q922G7, Q9WVR0	Gene names	Tekt2
Domain Architecture
Description	Tektin-2 (Testicular tektin) (Tektin-t).

PLVAP_MOUSE
NC score	0.051608 (rank : 1356)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	479	Target Neighborhood Hits	210	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

MARK1_MOUSE
NC score	0.051583 (rank : 1357)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	479	Target Neighborhood Hits	886	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

CENPU_HUMAN
NC score	0.051580 (rank : 1358)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	479	Target Neighborhood Hits	289	Shared Neighborhood Hits	90
SwissProt Accessions	Q71F23, Q32Q71, Q9H5G1	Gene names	MLF1IP, CENPU, ICEN24, KLIP1
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (CENP-U(50)) (CENP-50) (Interphase centromere complex protein 24) (MLF1-interacting protein) (KSHV latent nuclear antigen-interacting protein 1).

NIM1_HUMAN
NC score	0.051515 (rank : 1359)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

SHLB2_HUMAN
NC score	0.051513 (rank : 1360)	θ value	θ > 10 (rank : 1271)
Query Neighborhood Hits	479	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

M3K15_HUMAN
NC score	0.051510 (rank : 1361)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	479	Target Neighborhood Hits	914	Shared Neighborhood Hits	69
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K3_HUMAN
NC score	0.051507 (rank : 1362)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	479	Target Neighborhood Hits	885	Shared Neighborhood Hits	61
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

KC1E_MOUSE
NC score	0.051420 (rank : 1363)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	479	Target Neighborhood Hits	728	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_HUMAN
NC score	0.051415 (rank : 1364)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	479	Target Neighborhood Hits	732	Shared Neighborhood Hits	56
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

TTBK2_MOUSE
NC score	0.051402 (rank : 1365)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	479	Target Neighborhood Hits	811	Shared Neighborhood Hits	59
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

A20A2_HUMAN
NC score	0.051384 (rank : 1366)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	479	Target Neighborhood Hits	716	Shared Neighborhood Hits	146
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

K0999_MOUSE
NC score	0.051367 (rank : 1367)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	479	Target Neighborhood Hits	931	Shared Neighborhood Hits	63
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

SN1L1_HUMAN
NC score	0.051364 (rank : 1368)	θ value	θ > 10 (rank : 1283)
Query Neighborhood Hits	479	Target Neighborhood Hits	911	Shared Neighborhood Hits	59
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

ACINU_MOUSE
NC score	0.051360 (rank : 1369)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	479	Target Neighborhood Hits	712	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

M3K3_MOUSE
NC score	0.051352 (rank : 1370)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	479	Target Neighborhood Hits	876	Shared Neighborhood Hits	61
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

ULK3_HUMAN
NC score	0.051340 (rank : 1371)	θ value	θ > 10 (rank : 1430)
Query Neighborhood Hits	479	Target Neighborhood Hits	830	Shared Neighborhood Hits	58
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PRP4B_HUMAN
NC score	0.051327 (rank : 1372)	θ value	θ > 10 (rank : 1188)
Query Neighborhood Hits	479	Target Neighborhood Hits	1030	Shared Neighborhood Hits	97
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

MARK1_HUMAN
NC score	0.051323 (rank : 1373)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	479	Target Neighborhood Hits	887	Shared Neighborhood Hits	59
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

KIF14_HUMAN
NC score	0.051313 (rank : 1374)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	479	Target Neighborhood Hits	732	Shared Neighborhood Hits	171
SwissProt Accessions	Q15058	Gene names	KIF14, KIAA0042
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF14.

LAMA2_MOUSE
NC score	0.051310 (rank : 1375)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	479	Target Neighborhood Hits	1198	Shared Neighborhood Hits	170
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

NIM1_MOUSE
NC score	0.051289 (rank : 1376)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	479	Target Neighborhood Hits	850	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PKHA1_HUMAN
NC score	0.051254 (rank : 1377)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	479	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

FGD4_MOUSE
NC score	0.051221 (rank : 1378)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	479	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

LAMB1_HUMAN
NC score	0.051213 (rank : 1379)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	479	Target Neighborhood Hits	1018	Shared Neighborhood Hits	180
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

UN13A_HUMAN
NC score	0.051210 (rank : 1380)	θ value	θ > 10 (rank : 1432)
Query Neighborhood Hits	479	Target Neighborhood Hits	285	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

K0999_HUMAN
NC score	0.051206 (rank : 1381)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	479	Target Neighborhood Hits	899	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

E2AK3_MOUSE
NC score	0.051191 (rank : 1382)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	479	Target Neighborhood Hits	851	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

PRP4B_MOUSE
NC score	0.051118 (rank : 1383)	θ value	θ > 10 (rank : 1189)
Query Neighborhood Hits	479	Target Neighborhood Hits	1040	Shared Neighborhood Hits	96
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

AAPK1_HUMAN
NC score	0.051081 (rank : 1384)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	479	Target Neighborhood Hits	842	Shared Neighborhood Hits	59
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

NUAK2_HUMAN
NC score	0.051054 (rank : 1385)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	479	Target Neighborhood Hits	874	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

CCD37_HUMAN
NC score	0.051013 (rank : 1386)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	479	Target Neighborhood Hits	248	Shared Neighborhood Hits	94
SwissProt Accessions	Q494V2, Q494V1, Q494V4, Q8N838	Gene names	CCDC37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 37.

AL2S2_HUMAN
NC score	0.050988 (rank : 1387)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	479	Target Neighborhood Hits	727	Shared Neighborhood Hits	56
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

TTK_HUMAN
NC score	0.050971 (rank : 1388)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	479	Target Neighborhood Hits	816	Shared Neighborhood Hits	60
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

IKKE_HUMAN
NC score	0.050949 (rank : 1389)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	479	Target Neighborhood Hits	837	Shared Neighborhood Hits	66
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KPCZ_HUMAN
NC score	0.050948 (rank : 1390)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	479	Target Neighborhood Hits	884	Shared Neighborhood Hits	75
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

AAPK1_MOUSE
NC score	0.050938 (rank : 1391)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	59
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

TLK1_MOUSE
NC score	0.050936 (rank : 1392)	θ value	θ > 10 (rank : 1374)
Query Neighborhood Hits	479	Target Neighborhood Hits	947	Shared Neighborhood Hits	121
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

MARK2_MOUSE
NC score	0.050828 (rank : 1393)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	479	Target Neighborhood Hits	1018	Shared Neighborhood Hits	64
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

TLK1_HUMAN
NC score	0.050795 (rank : 1394)	θ value	θ > 10 (rank : 1373)
Query Neighborhood Hits	479	Target Neighborhood Hits	967	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TTBK2_HUMAN
NC score	0.050771 (rank : 1395)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	479	Target Neighborhood Hits	822	Shared Neighborhood Hits	59
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

M4K1_MOUSE
NC score	0.050696 (rank : 1396)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	479	Target Neighborhood Hits	858	Shared Neighborhood Hits	58
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

TSSK2_HUMAN
NC score	0.050683 (rank : 1397)	θ value	θ > 10 (rank : 1405)
Query Neighborhood Hits	479	Target Neighborhood Hits	826	Shared Neighborhood Hits	58
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

PKN1_MOUSE
NC score	0.050642 (rank : 1398)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	479	Target Neighborhood Hits	888	Shared Neighborhood Hits	73
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

CEP72_MOUSE
NC score	0.050629 (rank : 1399)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	479	Target Neighborhood Hits	381	Shared Neighborhood Hits	106
SwissProt Accessions	Q9D3R3, Q8BM53, Q9D0B7	Gene names	Cep72
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

WTAP_MOUSE
NC score	0.050614 (rank : 1400)	θ value	θ > 10 (rank : 1451)
Query Neighborhood Hits	479	Target Neighborhood Hits	250	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ER69	Gene names	Wtap
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

AAPK2_HUMAN
NC score	0.050583 (rank : 1401)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	479	Target Neighborhood Hits	843	Shared Neighborhood Hits	58
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

NEK8_HUMAN
NC score	0.050570 (rank : 1402)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NUCB1_MOUSE
NC score	0.050558 (rank : 1403)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	479	Target Neighborhood Hits	414	Shared Neighborhood Hits	116
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

FGD3_MOUSE
NC score	0.050557 (rank : 1404)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	479	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

GCP60_MOUSE
NC score	0.050554 (rank : 1405)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	479	Target Neighborhood Hits	395	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

MYO1A_HUMAN
NC score	0.050510 (rank : 1406)	θ value	θ > 10 (rank : 1073)
Query Neighborhood Hits	479	Target Neighborhood Hits	67	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

MASTL_HUMAN
NC score	0.050494 (rank : 1407)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	479	Target Neighborhood Hits	894	Shared Neighborhood Hits	59
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

K2C5_HUMAN
NC score	0.050395 (rank : 1408)	θ value	4.03905 (rank : 402)
Query Neighborhood Hits	479	Target Neighborhood Hits	506	Shared Neighborhood Hits	153
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

KPCZ_MOUSE
NC score	0.050361 (rank : 1409)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	479	Target Neighborhood Hits	882	Shared Neighborhood Hits	73
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

SPTB1_HUMAN
NC score	0.050360 (rank : 1410)	θ value	θ > 10 (rank : 1298)
Query Neighborhood Hits	479	Target Neighborhood Hits	541	Shared Neighborhood Hits	137
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

M3K2_HUMAN
NC score	0.050314 (rank : 1411)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	479	Target Neighborhood Hits	849	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

NEK8_MOUSE
NC score	0.050302 (rank : 1412)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

MYO1B_MOUSE
NC score	0.050283 (rank : 1413)	θ value	θ > 10 (rank : 1075)
Query Neighborhood Hits	479	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

K2C4_MOUSE
NC score	0.050275 (rank : 1414)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	479	Target Neighborhood Hits	521	Shared Neighborhood Hits	161
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

FGD4_HUMAN
NC score	0.050266 (rank : 1415)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	479	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

MYO1B_HUMAN
NC score	0.050265 (rank : 1416)	θ value	θ > 10 (rank : 1074)
Query Neighborhood Hits	479	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	O43795, O43794, Q7Z6L5	Gene names	MYO1B
Domain Architecture	No domain graphic available
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

SDPR_HUMAN
NC score	0.050263 (rank : 1417)	θ value	θ > 10 (rank : 1254)
Query Neighborhood Hits	479	Target Neighborhood Hits	337	Shared Neighborhood Hits	79
SwissProt Accessions	O95810	Gene names	SDPR
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein) (PS-p68).

MYO1C_MOUSE
NC score	0.050256 (rank : 1418)	θ value	θ > 10 (rank : 1077)
Query Neighborhood Hits	479	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

MYO1D_HUMAN
NC score	0.050242 (rank : 1419)	θ value	θ > 10 (rank : 1078)
Query Neighborhood Hits	479	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	O94832, Q8NHP9	Gene names	MYO1D, KIAA0727
Domain Architecture
Description	Myosin Id.

MYO1C_HUMAN
NC score	0.050226 (rank : 1420)	θ value	θ > 10 (rank : 1076)
Query Neighborhood Hits	479	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

ULK3_MOUSE
NC score	0.050223 (rank : 1421)	θ value	θ > 10 (rank : 1431)
Query Neighborhood Hits	479	Target Neighborhood Hits	872	Shared Neighborhood Hits	62
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

MYO1D_MOUSE
NC score	0.050187 (rank : 1422)	θ value	θ > 10 (rank : 1079)
Query Neighborhood Hits	479	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SYD0, Q5SSK7, Q8BWY5	Gene names	Myo1d
Domain Architecture	No domain graphic available
Description	Myosin Id.

DAPK3_HUMAN
NC score	0.050172 (rank : 1423)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	479	Target Neighborhood Hits	945	Shared Neighborhood Hits	105
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

K1C14_MOUSE
NC score	0.049874 (rank : 1424)	θ value	2.36792 (rank : 363)
Query Neighborhood Hits	479	Target Neighborhood Hits	501	Shared Neighborhood Hits	154
SwissProt Accessions	Q61781, Q91VQ4	Gene names	Krt14, Krt1-14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

CN094_HUMAN
NC score	0.049265 (rank : 1425)	θ value	8.99809 (rank : 455)
Query Neighborhood Hits	479	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H6D7, Q86T15, Q86T16, Q86U43, Q9NX59	Gene names	C14orf94
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf94.

K2C5_MOUSE
NC score	0.048787 (rank : 1426)	θ value	2.36792 (rank : 364)
Query Neighborhood Hits	479	Target Neighborhood Hits	505	Shared Neighborhood Hits	154
SwissProt Accessions	Q922U2, Q920F2	Gene names	Krt5, Krt2-5
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5).

TMCO3_MOUSE
NC score	0.048632 (rank : 1427)	θ value	8.99809 (rank : 477)
Query Neighborhood Hits	479	Target Neighborhood Hits	241	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BH01, Q3UFX1, Q7TMT5, Q8BGL4, Q8R303	Gene names	Tmco3
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor.

LAMA4_MOUSE
NC score	0.047027 (rank : 1428)	θ value	0.813845 (rank : 295)
Query Neighborhood Hits	479	Target Neighborhood Hits	584	Shared Neighborhood Hits	117
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

K2C6A_MOUSE
NC score	0.046602 (rank : 1429)	θ value	8.99809 (rank : 461)
Query Neighborhood Hits	479	Target Neighborhood Hits	481	Shared Neighborhood Hits	147
SwissProt Accessions	P50446, Q9Z332	Gene names	Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin) (Keratin-6 alpha) (mK6-alpha).

K1C14_HUMAN
NC score	0.045629 (rank : 1430)	θ value	4.03905 (rank : 401)
Query Neighborhood Hits	479	Target Neighborhood Hits	491	Shared Neighborhood Hits	148
SwissProt Accessions	P02533, Q14715, Q53XY3, Q9BUE3, Q9UBN2, Q9UBN3, Q9UCY4	Gene names	KRT14
Domain Architecture
Description	Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14).

ARHG2_MOUSE
NC score	0.044483 (rank : 1431)	θ value	6.88961 (rank : 431)
Query Neighborhood Hits	479	Target Neighborhood Hits	120	Shared Neighborhood Hits	23
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

GCF_HUMAN
NC score	0.043805 (rank : 1432)	θ value	0.813845 (rank : 291)
Query Neighborhood Hits	479	Target Neighborhood Hits	107	Shared Neighborhood Hits	42
SwissProt Accessions	P16383, O95032	Gene names	TCF9, C2orf3
Domain Architecture	No domain graphic available
Description	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9).

CIP1_HUMAN
NC score	0.043687 (rank : 1433)	θ value	1.81305 (rank : 336)
Query Neighborhood Hits	479	Target Neighborhood Hits	83	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NPC3	Gene names	CCNB1IP1, C14orf18, HEI10
Domain Architecture	No domain graphic available
Description	Cyclin-B1-interacting protein 1 (EC 6.3.2.-) (Human enhancer of invasion 10) (E3 ubiquitin-protein ligase HEI10).

K1C16_MOUSE
NC score	0.042487 (rank : 1434)	θ value	6.88961 (rank : 435)
Query Neighborhood Hits	479	Target Neighborhood Hits	444	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z2K1	Gene names	Krt16, Krt1-16
Domain Architecture
Description	Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16).

STAT2_MOUSE
NC score	0.041951 (rank : 1435)	θ value	5.27518 (rank : 426)
Query Neighborhood Hits	479	Target Neighborhood Hits	175	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

K1C16_HUMAN
NC score	0.040786 (rank : 1436)	θ value	6.88961 (rank : 434)
Query Neighborhood Hits	479	Target Neighborhood Hits	440	Shared Neighborhood Hits	134
SwissProt Accessions	P08779, P30654, Q16402, Q9UBG8	Gene names	KRT16, KRT16A
Domain Architecture
Description	Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16).

STAT2_HUMAN
NC score	0.037279 (rank : 1437)	θ value	8.99809 (rank : 473)
Query Neighborhood Hits	479	Target Neighborhood Hits	99	Shared Neighborhood Hits	35
SwissProt Accessions	P52630, Q16430, Q16431	Gene names	STAT2
Domain Architecture
Description	Signal transducer and activator of transcription 2 (p113).

FCER2_MOUSE
NC score	0.033682 (rank : 1438)	θ value	3.0926 (rank : 378)
Query Neighborhood Hits	479	Target Neighborhood Hits	392	Shared Neighborhood Hits	97
SwissProt Accessions	P20693, Q61556, Q61557	Gene names	Fcer2, Fcer2a
Domain Architecture
Description	Low affinity immunoglobulin epsilon Fc receptor (Lymphocyte IGE receptor) (Fc-epsilon-RII) (CD23 antigen).

K0460_MOUSE
NC score	0.032027 (rank : 1439)	θ value	1.81305 (rank : 340)
Query Neighborhood Hits	479	Target Neighborhood Hits	374	Shared Neighborhood Hits	52
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

NCOR1_HUMAN
NC score	0.031218 (rank : 1440)	θ value	6.88961 (rank : 441)
Query Neighborhood Hits	479	Target Neighborhood Hits	577	Shared Neighborhood Hits	72
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

SPG3A_MOUSE
NC score	0.030175 (rank : 1441)	θ value	0.62314 (rank : 284)
Query Neighborhood Hits	479	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BH66, Q8BJH5	Gene names	Spg3a, Gbp3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3).

KCY_MOUSE
NC score	0.030073 (rank : 1442)	θ value	5.27518 (rank : 420)
Query Neighborhood Hits	479	Target Neighborhood Hits	25	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DBP5	Gene names	Cmpk, Cmk, Uck, Umk, Umpk
Domain Architecture
Description	UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase).

SPG3A_HUMAN
NC score	0.026684 (rank : 1443)	θ value	1.81305 (rank : 347)
Query Neighborhood Hits	479	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXF7, O95890, Q96FK0	Gene names	SPG3A, GBP3
Domain Architecture
Description	Atlastin (GTP-binding protein 3) (Guanine nucleotide-binding protein 3) (GBP-3) (Brain-specific GTP-binding protein).

NCOR1_MOUSE
NC score	0.026171 (rank : 1444)	θ value	6.88961 (rank : 442)
Query Neighborhood Hits	479	Target Neighborhood Hits	521	Shared Neighborhood Hits	61
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

TTC19_HUMAN
NC score	0.022314 (rank : 1445)	θ value	3.0926 (rank : 393)
Query Neighborhood Hits	479	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q6DKK2, Q7L3U8, Q9NXB2	Gene names	TTC19
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 19 (TPR repeat protein 19).

OCLN_HUMAN
NC score	0.019764 (rank : 1446)	θ value	8.99809 (rank : 469)
Query Neighborhood Hits	479	Target Neighborhood Hits	131	Shared Neighborhood Hits	46
SwissProt Accessions	Q16625, Q8N6K1	Gene names	OCLN
Domain Architecture
Description	Occludin.

ERCC6_HUMAN
NC score	0.019518 (rank : 1447)	θ value	0.365318 (rank : 255)
Query Neighborhood Hits	479	Target Neighborhood Hits	247	Shared Neighborhood Hits	41
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

ACTN3_HUMAN
NC score	0.017082 (rank : 1448)	θ value	8.99809 (rank : 450)
Query Neighborhood Hits	479	Target Neighborhood Hits	272	Shared Neighborhood Hits	60
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

AR13B_HUMAN
NC score	0.014841 (rank : 1449)	θ value	8.99809 (rank : 451)
Query Neighborhood Hits	479	Target Neighborhood Hits	528	Shared Neighborhood Hits	82
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

TTC19_MOUSE
NC score	0.014090 (rank : 1450)	θ value	6.88961 (rank : 448)
Query Neighborhood Hits	479	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CC21	Gene names	Ttc19
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 19 (TPR repeat protein 19).

MCM3A_HUMAN
NC score	0.013199 (rank : 1451)	θ value	8.99809 (rank : 464)
Query Neighborhood Hits	479	Target Neighborhood Hits	86	Shared Neighborhood Hits	13
SwissProt Accessions	O60318, Q9UMT4	Gene names	MCM3AP, GANP, KIAA0572, MAP80
Domain Architecture
Description	80 kDa MCM3-associated protein (GANP protein).

MCM3A_MOUSE
NC score	0.011677 (rank : 1452)	θ value	8.99809 (rank : 465)
Query Neighborhood Hits	479	Target Neighborhood Hits	79	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WUU9	Gene names	Mcm3ap, Ganp, Map80
Domain Architecture
Description	80 kDa MCM3-associated protein (GANP protein).

TBC14_MOUSE
NC score	0.011215 (rank : 1453)	θ value	3.0926 (rank : 391)
Query Neighborhood Hits	479	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CGA2, Q8CHA5	Gene names	Tbc1d14, D5Ertd110e, Kiaa1322
Domain Architecture
Description	TBC1 domain family member 14.

BRPF3_HUMAN
NC score	0.005386 (rank : 1454)	θ value	2.36792 (rank : 350)
Query Neighborhood Hits	479	Target Neighborhood Hits	217	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

CCNL2_MOUSE
NC score	0.005326 (rank : 1455)	θ value	8.99809 (rank : 454)
Query Neighborhood Hits	479	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJA7, Q5XK66, Q60995, Q8C136, Q8CIJ8, Q99L73, Q9QXH5	Gene names	Ccnl2, Ania6b
Domain Architecture	No domain graphic available
Description	Cyclin-L2 (Cyclin Ania-6b) (Paneth cell-enhanced expression protein) (PCEE).

SYP2L_HUMAN
NC score	0.002396 (rank : 1456)	θ value	8.99809 (rank : 475)
Query Neighborhood Hits	479	Target Neighborhood Hits	400	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

LTBP2_MOUSE
NC score	0.002301 (rank : 1457)	θ value	0.47712 (rank : 265)
Query Neighborhood Hits	479	Target Neighborhood Hits	617	Shared Neighborhood Hits	7
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).