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Network neighborhood for query Sequence : BCAR1_HUMAN

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BCAR1_HUMAN
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BCAR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	554	Target Neighborhood Hits	554	Shared Neighborhood Hits	554
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0 (rank : 2)	NC score	0.956575 (rank : 2)
Query Neighborhood Hits	554	Target Neighborhood Hits	438	Shared Neighborhood Hits	362
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_MOUSE
θ value	3.39372e-140 (rank : 3)	NC score	0.863761 (rank : 3)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	166
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
θ value	5.41814e-138 (rank : 4)	NC score	0.860937 (rank : 4)
Query Neighborhood Hits	554	Target Neighborhood Hits	259	Shared Neighborhood Hits	178
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

EFS_HUMAN
θ value	1.52067e-31 (rank : 5)	NC score	0.726437 (rank : 6)
Query Neighborhood Hits	554	Target Neighborhood Hits	348	Shared Neighborhood Hits	211
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	5.40856e-29 (rank : 6)	NC score	0.719967 (rank : 7)
Query Neighborhood Hits	554	Target Neighborhood Hits	389	Shared Neighborhood Hits	231
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CT032_HUMAN
θ value	2.27234e-27 (rank : 7)	NC score	0.762174 (rank : 5)
Query Neighborhood Hits	554	Target Neighborhood Hits	235	Shared Neighborhood Hits	156
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

IASPP_MOUSE
θ value	1.53129e-07 (rank : 8)	NC score	0.370331 (rank : 33)
Query Neighborhood Hits	554	Target Neighborhood Hits	1024	Shared Neighborhood Hits	324
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PPIP1_HUMAN
θ value	4.45536e-07 (rank : 9)	NC score	0.432120 (rank : 14)
Query Neighborhood Hits	554	Target Neighborhood Hits	389	Shared Neighborhood Hits	175
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

IASPP_HUMAN
θ value	5.81887e-07 (rank : 10)	NC score	0.355697 (rank : 41)
Query Neighborhood Hits	554	Target Neighborhood Hits	688	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CD2AP_MOUSE
θ value	9.92553e-07 (rank : 11)	NC score	0.481584 (rank : 8)
Query Neighborhood Hits	554	Target Neighborhood Hits	336	Shared Neighborhood Hits	188
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
θ value	1.29631e-06 (rank : 12)	NC score	0.464245 (rank : 11)
Query Neighborhood Hits	554	Target Neighborhood Hits	332	Shared Neighborhood Hits	177
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

PPIP1_MOUSE
θ value	2.88788e-06 (rank : 13)	NC score	0.428747 (rank : 15)
Query Neighborhood Hits	554	Target Neighborhood Hits	377	Shared Neighborhood Hits	170
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ASPP1_HUMAN
θ value	3.77169e-06 (rank : 14)	NC score	0.295951 (rank : 76)
Query Neighborhood Hits	554	Target Neighborhood Hits	956	Shared Neighborhood Hits	213
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ITSN1_MOUSE
θ value	6.43352e-06 (rank : 15)	NC score	0.280471 (rank : 83)
Query Neighborhood Hits	554	Target Neighborhood Hits	1669	Shared Neighborhood Hits	245
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SH3K1_HUMAN
θ value	6.43352e-06 (rank : 16)	NC score	0.461250 (rank : 12)
Query Neighborhood Hits	554	Target Neighborhood Hits	341	Shared Neighborhood Hits	171
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PEX13_MOUSE
θ value	8.40245e-06 (rank : 17)	NC score	0.426211 (rank : 16)
Query Neighborhood Hits	554	Target Neighborhood Hits	126	Shared Neighborhood Hits	109
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ASPP1_MOUSE
θ value	1.09739e-05 (rank : 18)	NC score	0.318428 (rank : 63)
Query Neighborhood Hits	554	Target Neighborhood Hits	1244	Shared Neighborhood Hits	300
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ARHG7_HUMAN
θ value	1.87187e-05 (rank : 19)	NC score	0.358142 (rank : 40)
Query Neighborhood Hits	554	Target Neighborhood Hits	347	Shared Neighborhood Hits	167
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

HCLS1_HUMAN
θ value	1.87187e-05 (rank : 20)	NC score	0.465190 (rank : 9)
Query Neighborhood Hits	554	Target Neighborhood Hits	358	Shared Neighborhood Hits	220
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MYO1F_HUMAN
θ value	1.87187e-05 (rank : 21)	NC score	0.194475 (rank : 124)
Query Neighborhood Hits	554	Target Neighborhood Hits	275	Shared Neighborhood Hits	170
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	1.87187e-05 (rank : 22)	NC score	0.193208 (rank : 125)
Query Neighborhood Hits	554	Target Neighborhood Hits	262	Shared Neighborhood Hits	162
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PEX13_HUMAN
θ value	2.44474e-05 (rank : 23)	NC score	0.423531 (rank : 17)
Query Neighborhood Hits	554	Target Neighborhood Hits	128	Shared Neighborhood Hits	110
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

M3KL4_HUMAN
θ value	3.19293e-05 (rank : 24)	NC score	0.129321 (rank : 219)
Query Neighborhood Hits	554	Target Neighborhood Hits	1087	Shared Neighborhood Hits	174
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CD2AP_HUMAN
θ value	4.1701e-05 (rank : 25)	NC score	0.464818 (rank : 10)
Query Neighborhood Hits	554	Target Neighborhood Hits	315	Shared Neighborhood Hits	180
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ITSN1_HUMAN
θ value	5.44631e-05 (rank : 26)	NC score	0.280642 (rank : 82)
Query Neighborhood Hits	554	Target Neighborhood Hits	1757	Shared Neighborhood Hits	266
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
θ value	0.000121331 (rank : 27)	NC score	0.281427 (rank : 81)
Query Neighborhood Hits	554	Target Neighborhood Hits	1173	Shared Neighborhood Hits	194
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SF3A2_MOUSE
θ value	0.000121331 (rank : 28)	NC score	0.179422 (rank : 140)
Query Neighborhood Hits	554	Target Neighborhood Hits	247	Shared Neighborhood Hits	84
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

M3K9_HUMAN
θ value	0.000158464 (rank : 29)	NC score	0.114773 (rank : 247)
Query Neighborhood Hits	554	Target Neighborhood Hits	1123	Shared Neighborhood Hits	194
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRC8_HUMAN
θ value	0.000158464 (rank : 30)	NC score	0.402873 (rank : 19)
Query Neighborhood Hits	554	Target Neighborhood Hits	269	Shared Neighborhood Hits	165
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

MYO1E_HUMAN
θ value	0.00020696 (rank : 31)	NC score	0.180018 (rank : 137)
Query Neighborhood Hits	554	Target Neighborhood Hits	293	Shared Neighborhood Hits	170
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SPTA2_HUMAN
θ value	0.00020696 (rank : 32)	NC score	0.182720 (rank : 135)
Query Neighborhood Hits	554	Target Neighborhood Hits	888	Shared Neighborhood Hits	171
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

VAV_HUMAN
θ value	0.00020696 (rank : 33)	NC score	0.304448 (rank : 72)
Query Neighborhood Hits	554	Target Neighborhood Hits	452	Shared Neighborhood Hits	168
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ASPP2_HUMAN
θ value	0.000270298 (rank : 34)	NC score	0.247851 (rank : 101)
Query Neighborhood Hits	554	Target Neighborhood Hits	1156	Shared Neighborhood Hits	218
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

GRB2_HUMAN
θ value	0.000270298 (rank : 35)	NC score	0.371430 (rank : 31)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	175
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.000270298 (rank : 36)	NC score	0.371066 (rank : 32)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	175
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

M3K11_HUMAN
θ value	0.000270298 (rank : 37)	NC score	0.125297 (rank : 226)
Query Neighborhood Hits	554	Target Neighborhood Hits	1136	Shared Neighborhood Hits	210
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MUC2_HUMAN
θ value	0.000270298 (rank : 38)	NC score	0.094146 (rank : 311)
Query Neighborhood Hits	554	Target Neighborhood Hits	906	Shared Neighborhood Hits	111
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SH3G2_MOUSE
θ value	0.000270298 (rank : 39)	NC score	0.397953 (rank : 20)
Query Neighborhood Hits	554	Target Neighborhood Hits	319	Shared Neighborhood Hits	166
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SRC8_MOUSE
θ value	0.000270298 (rank : 40)	NC score	0.403415 (rank : 18)
Query Neighborhood Hits	554	Target Neighborhood Hits	292	Shared Neighborhood Hits	169
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

VAV_MOUSE
θ value	0.000270298 (rank : 41)	NC score	0.303092 (rank : 73)
Query Neighborhood Hits	554	Target Neighborhood Hits	430	Shared Neighborhood Hits	167
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

AHI1_HUMAN
θ value	0.00035302 (rank : 42)	NC score	0.289683 (rank : 80)
Query Neighborhood Hits	554	Target Neighborhood Hits	537	Shared Neighborhood Hits	169
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG7_MOUSE
θ value	0.00035302 (rank : 43)	NC score	0.350203 (rank : 47)
Query Neighborhood Hits	554	Target Neighborhood Hits	396	Shared Neighborhood Hits	169
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP2_MOUSE
θ value	0.00035302 (rank : 44)	NC score	0.379513 (rank : 27)
Query Neighborhood Hits	554	Target Neighborhood Hits	297	Shared Neighborhood Hits	178
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

HCLS1_MOUSE
θ value	0.00035302 (rank : 45)	NC score	0.440587 (rank : 13)
Query Neighborhood Hits	554	Target Neighborhood Hits	329	Shared Neighborhood Hits	201
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ITSN2_MOUSE
θ value	0.00035302 (rank : 46)	NC score	0.266563 (rank : 86)
Query Neighborhood Hits	554	Target Neighborhood Hits	1371	Shared Neighborhood Hits	199
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SH3G2_HUMAN
θ value	0.000461057 (rank : 47)	NC score	0.390188 (rank : 24)
Query Neighborhood Hits	554	Target Neighborhood Hits	324	Shared Neighborhood Hits	163
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

NCK1_HUMAN
θ value	0.000602161 (rank : 48)	NC score	0.371623 (rank : 30)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	172
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PTN23_MOUSE
θ value	0.000602161 (rank : 49)	NC score	0.081045 (rank : 365)
Query Neighborhood Hits	554	Target Neighborhood Hits	726	Shared Neighborhood Hits	140
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

GSCR1_HUMAN
θ value	0.000786445 (rank : 50)	NC score	0.166441 (rank : 155)
Query Neighborhood Hits	554	Target Neighborhood Hits	674	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MBD6_HUMAN
θ value	0.00102713 (rank : 51)	NC score	0.150952 (rank : 174)
Query Neighborhood Hits	554	Target Neighborhood Hits	349	Shared Neighborhood Hits	82
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

SH3G1_MOUSE
θ value	0.00102713 (rank : 52)	NC score	0.378406 (rank : 28)
Query Neighborhood Hits	554	Target Neighborhood Hits	291	Shared Neighborhood Hits	161
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CD2L7_HUMAN
θ value	0.00134147 (rank : 53)	NC score	0.034489 (rank : 697)
Query Neighborhood Hits	554	Target Neighborhood Hits	1275	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

GRAP2_HUMAN
θ value	0.00134147 (rank : 54)	NC score	0.368135 (rank : 37)
Query Neighborhood Hits	554	Target Neighborhood Hits	304	Shared Neighborhood Hits	180
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SF3A2_HUMAN
θ value	0.00134147 (rank : 55)	NC score	0.178625 (rank : 142)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	87
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

NCK2_HUMAN
θ value	0.00175202 (rank : 56)	NC score	0.358592 (rank : 39)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	173
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RGS3_MOUSE
θ value	0.00175202 (rank : 57)	NC score	0.193000 (rank : 126)
Query Neighborhood Hits	554	Target Neighborhood Hits	1621	Shared Neighborhood Hits	306
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BAT2_HUMAN
θ value	0.00228821 (rank : 58)	NC score	0.178938 (rank : 141)
Query Neighborhood Hits	554	Target Neighborhood Hits	931	Shared Neighborhood Hits	197
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

DOK1_HUMAN
θ value	0.00228821 (rank : 59)	NC score	0.080864 (rank : 366)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

TITIN_HUMAN
θ value	0.00228821 (rank : 60)	NC score	0.034920 (rank : 695)
Query Neighborhood Hits	554	Target Neighborhood Hits	2923	Shared Neighborhood Hits	188
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

M3K10_HUMAN
θ value	0.00298849 (rank : 61)	NC score	0.100519 (rank : 283)
Query Neighborhood Hits	554	Target Neighborhood Hits	1071	Shared Neighborhood Hits	163
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MGR1_HUMAN
θ value	0.00298849 (rank : 62)	NC score	0.041503 (rank : 679)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0	Gene names	GRM1, GPRC1A, MGLUR1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

SPTA1_HUMAN
θ value	0.00298849 (rank : 63)	NC score	0.162253 (rank : 161)
Query Neighborhood Hits	554	Target Neighborhood Hits	748	Shared Neighborhood Hits	167
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TCGAP_HUMAN
θ value	0.00298849 (rank : 64)	NC score	0.248133 (rank : 100)
Query Neighborhood Hits	554	Target Neighborhood Hits	872	Shared Neighborhood Hits	300
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ABI2_HUMAN
θ value	0.00390308 (rank : 65)	NC score	0.389557 (rank : 25)
Query Neighborhood Hits	554	Target Neighborhood Hits	350	Shared Neighborhood Hits	187
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.00390308 (rank : 66)	NC score	0.382878 (rank : 26)
Query Neighborhood Hits	554	Target Neighborhood Hits	266	Shared Neighborhood Hits	167
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARHG9_HUMAN
θ value	0.00390308 (rank : 67)	NC score	0.261421 (rank : 92)
Query Neighborhood Hits	554	Target Neighborhood Hits	235	Shared Neighborhood Hits	145
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

BAT2_MOUSE
θ value	0.00390308 (rank : 68)	NC score	0.169529 (rank : 153)
Query Neighborhood Hits	554	Target Neighborhood Hits	947	Shared Neighborhood Hits	212
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

DNMBP_HUMAN
θ value	0.00390308 (rank : 69)	NC score	0.350250 (rank : 46)
Query Neighborhood Hits	554	Target Neighborhood Hits	413	Shared Neighborhood Hits	181
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP_MOUSE
θ value	0.00390308 (rank : 70)	NC score	0.355198 (rank : 43)
Query Neighborhood Hits	554	Target Neighborhood Hits	309	Shared Neighborhood Hits	177
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

LDB3_MOUSE
θ value	0.00390308 (rank : 71)	NC score	0.070639 (rank : 435)
Query Neighborhood Hits	554	Target Neighborhood Hits	510	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

RERE_HUMAN
θ value	0.00390308 (rank : 72)	NC score	0.153088 (rank : 170)
Query Neighborhood Hits	554	Target Neighborhood Hits	779	Shared Neighborhood Hits	151
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RUSC1_HUMAN
θ value	0.00390308 (rank : 73)	NC score	0.295475 (rank : 77)
Query Neighborhood Hits	554	Target Neighborhood Hits	226	Shared Neighborhood Hits	144
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

VINEX_MOUSE
θ value	0.00390308 (rank : 74)	NC score	0.397618 (rank : 21)
Query Neighborhood Hits	554	Target Neighborhood Hits	286	Shared Neighborhood Hits	173
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YLPM1_HUMAN
θ value	0.00390308 (rank : 75)	NC score	0.149675 (rank : 175)
Query Neighborhood Hits	554	Target Neighborhood Hits	670	Shared Neighborhood Hits	148
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

DDEF2_HUMAN
θ value	0.00509761 (rank : 76)	NC score	0.185634 (rank : 133)
Query Neighborhood Hits	554	Target Neighborhood Hits	599	Shared Neighborhood Hits	175
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.00509761 (rank : 77)	NC score	0.191227 (rank : 129)
Query Neighborhood Hits	554	Target Neighborhood Hits	625	Shared Neighborhood Hits	179
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RAPH1_HUMAN
θ value	0.00509761 (rank : 78)	NC score	0.149128 (rank : 176)
Query Neighborhood Hits	554	Target Neighborhood Hits	593	Shared Neighborhood Hits	142
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SHAN1_HUMAN
θ value	0.00509761 (rank : 79)	NC score	0.141535 (rank : 191)
Query Neighborhood Hits	554	Target Neighborhood Hits	1041	Shared Neighborhood Hits	218
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SPT5H_HUMAN
θ value	0.00509761 (rank : 80)	NC score	0.186015 (rank : 132)
Query Neighborhood Hits	554	Target Neighborhood Hits	436	Shared Neighborhood Hits	147
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	0.00509761 (rank : 81)	NC score	0.185598 (rank : 134)
Query Neighborhood Hits	554	Target Neighborhood Hits	437	Shared Neighborhood Hits	146
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

LDB3_HUMAN
θ value	0.00665767 (rank : 82)	NC score	0.063858 (rank : 495)
Query Neighborhood Hits	554	Target Neighborhood Hits	497	Shared Neighborhood Hits	77
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PHC2_HUMAN
θ value	0.00665767 (rank : 83)	NC score	0.126262 (rank : 224)
Query Neighborhood Hits	554	Target Neighborhood Hits	388	Shared Neighborhood Hits	137
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

ARHG9_MOUSE
θ value	0.00869519 (rank : 84)	NC score	0.259257 (rank : 96)
Query Neighborhood Hits	554	Target Neighborhood Hits	234	Shared Neighborhood Hits	145
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

GRAP_HUMAN
θ value	0.00869519 (rank : 85)	NC score	0.348759 (rank : 48)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	181
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NPHP1_MOUSE
θ value	0.00869519 (rank : 86)	NC score	0.317291 (rank : 65)
Query Neighborhood Hits	554	Target Neighborhood Hits	267	Shared Neighborhood Hits	151
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_MOUSE
θ value	0.00869519 (rank : 87)	NC score	0.298388 (rank : 75)
Query Neighborhood Hits	554	Target Neighborhood Hits	467	Shared Neighborhood Hits	173
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SFPQ_HUMAN
θ value	0.00869519 (rank : 88)	NC score	0.114845 (rank : 246)
Query Neighborhood Hits	554	Target Neighborhood Hits	986	Shared Neighborhood Hits	137
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SH3G3_HUMAN
θ value	0.00869519 (rank : 89)	NC score	0.373774 (rank : 29)
Query Neighborhood Hits	554	Target Neighborhood Hits	222	Shared Neighborhood Hits	155
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

TCGAP_MOUSE
θ value	0.00869519 (rank : 90)	NC score	0.188088 (rank : 130)
Query Neighborhood Hits	554	Target Neighborhood Hits	409	Shared Neighborhood Hits	162
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	0.00869519 (rank : 91)	NC score	0.390302 (rank : 23)
Query Neighborhood Hits	554	Target Neighborhood Hits	270	Shared Neighborhood Hits	165
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

WBS14_MOUSE
θ value	0.00869519 (rank : 92)	NC score	0.072733 (rank : 413)
Query Neighborhood Hits	554	Target Neighborhood Hits	171	Shared Neighborhood Hits	42
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

ARI1B_HUMAN
θ value	0.0113563 (rank : 93)	NC score	0.137894 (rank : 199)
Query Neighborhood Hits	554	Target Neighborhood Hits	567	Shared Neighborhood Hits	151
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

DNMBP_MOUSE
θ value	0.0113563 (rank : 94)	NC score	0.340574 (rank : 53)
Query Neighborhood Hits	554	Target Neighborhood Hits	435	Shared Neighborhood Hits	192
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

OSTF1_HUMAN
θ value	0.0113563 (rank : 95)	NC score	0.299247 (rank : 74)
Query Neighborhood Hits	554	Target Neighborhood Hits	466	Shared Neighborhood Hits	172
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

RERE_MOUSE
θ value	0.0113563 (rank : 96)	NC score	0.162254 (rank : 160)
Query Neighborhood Hits	554	Target Neighborhood Hits	785	Shared Neighborhood Hits	155
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RNC_HUMAN
θ value	0.0113563 (rank : 97)	NC score	0.116510 (rank : 242)
Query Neighborhood Hits	554	Target Neighborhood Hits	176	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

BRD4_MOUSE
θ value	0.0148317 (rank : 98)	NC score	0.107613 (rank : 266)
Query Neighborhood Hits	554	Target Neighborhood Hits	845	Shared Neighborhood Hits	129
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CRKL_HUMAN
θ value	0.0148317 (rank : 99)	NC score	0.330931 (rank : 57)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	174
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GAK2_HUMAN
θ value	0.0148317 (rank : 100)	NC score	0.143128 (rank : 185)
Query Neighborhood Hits	554	Target Neighborhood Hits	406	Shared Neighborhood Hits	162
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

OGFR_HUMAN
θ value	0.0148317 (rank : 101)	NC score	0.191557 (rank : 128)
Query Neighborhood Hits	554	Target Neighborhood Hits	1582	Shared Neighborhood Hits	292
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SRBS1_HUMAN
θ value	0.0148317 (rank : 102)	NC score	0.360721 (rank : 38)
Query Neighborhood Hits	554	Target Neighborhood Hits	396	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

WASL_HUMAN
θ value	0.0148317 (rank : 103)	NC score	0.134469 (rank : 208)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	90
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASL_MOUSE
θ value	0.0148317 (rank : 104)	NC score	0.139633 (rank : 192)
Query Neighborhood Hits	554	Target Neighborhood Hits	339	Shared Neighborhood Hits	89
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ZIMP7_MOUSE
θ value	0.0148317 (rank : 105)	NC score	0.121518 (rank : 231)
Query Neighborhood Hits	554	Target Neighborhood Hits	566	Shared Neighborhood Hits	167
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

AHI1_MOUSE
θ value	0.0193708 (rank : 106)	NC score	0.278289 (rank : 84)
Query Neighborhood Hits	554	Target Neighborhood Hits	496	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

BRD4_HUMAN
θ value	0.0193708 (rank : 107)	NC score	0.110092 (rank : 261)
Query Neighborhood Hits	554	Target Neighborhood Hits	851	Shared Neighborhood Hits	138
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CSKI1_MOUSE
θ value	0.0193708 (rank : 108)	NC score	0.103717 (rank : 273)
Query Neighborhood Hits	554	Target Neighborhood Hits	1031	Shared Neighborhood Hits	231
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

GAK11_HUMAN
θ value	0.0193708 (rank : 109)	NC score	0.143588 (rank : 184)
Query Neighborhood Hits	554	Target Neighborhood Hits	409	Shared Neighborhood Hits	164
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
θ value	0.0193708 (rank : 110)	NC score	0.136882 (rank : 201)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	151
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	0.0193708 (rank : 111)	NC score	0.143730 (rank : 183)
Query Neighborhood Hits	554	Target Neighborhood Hits	415	Shared Neighborhood Hits	164
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HGS_HUMAN
θ value	0.0193708 (rank : 112)	NC score	0.097019 (rank : 303)
Query Neighborhood Hits	554	Target Neighborhood Hits	517	Shared Neighborhood Hits	103
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

SF01_HUMAN
θ value	0.0193708 (rank : 113)	NC score	0.130634 (rank : 214)
Query Neighborhood Hits	554	Target Neighborhood Hits	287	Shared Neighborhood Hits	88
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SFPQ_MOUSE
θ value	0.0193708 (rank : 114)	NC score	0.118487 (rank : 239)
Query Neighborhood Hits	554	Target Neighborhood Hits	958	Shared Neighborhood Hits	131
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

EPS8_MOUSE
θ value	0.0252991 (rank : 115)	NC score	0.196865 (rank : 118)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	115
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

GAK5_HUMAN
θ value	0.0252991 (rank : 116)	NC score	0.144966 (rank : 180)
Query Neighborhood Hits	554	Target Neighborhood Hits	429	Shared Neighborhood Hits	164
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK6_HUMAN
θ value	0.0252991 (rank : 117)	NC score	0.141835 (rank : 188)
Query Neighborhood Hits	554	Target Neighborhood Hits	392	Shared Neighborhood Hits	160
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

LOXL1_MOUSE
θ value	0.0252991 (rank : 118)	NC score	0.051552 (rank : 641)
Query Neighborhood Hits	554	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

MLL2_HUMAN
θ value	0.0252991 (rank : 119)	NC score	0.138109 (rank : 198)
Query Neighborhood Hits	554	Target Neighborhood Hits	1788	Shared Neighborhood Hits	240
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_HUMAN
θ value	0.0252991 (rank : 120)	NC score	0.170293 (rank : 150)
Query Neighborhood Hits	554	Target Neighborhood Hits	1644	Shared Neighborhood Hits	281
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MYST3_MOUSE
θ value	0.0252991 (rank : 121)	NC score	0.071875 (rank : 423)
Query Neighborhood Hits	554	Target Neighborhood Hits	688	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

NPHP1_HUMAN
θ value	0.0252991 (rank : 122)	NC score	0.289943 (rank : 79)
Query Neighborhood Hits	554	Target Neighborhood Hits	288	Shared Neighborhood Hits	143
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PRP1_HUMAN
θ value	0.0252991 (rank : 123)	NC score	0.146699 (rank : 178)
Query Neighborhood Hits	554	Target Neighborhood Hits	385	Shared Neighborhood Hits	97
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

SON_HUMAN
θ value	0.0252991 (rank : 124)	NC score	0.204806 (rank : 115)
Query Neighborhood Hits	554	Target Neighborhood Hits	1568	Shared Neighborhood Hits	290
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SRBS1_MOUSE
θ value	0.0252991 (rank : 125)	NC score	0.368951 (rank : 34)
Query Neighborhood Hits	554	Target Neighborhood Hits	409	Shared Neighborhood Hits	187
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

WASIP_HUMAN
θ value	0.0252991 (rank : 126)	NC score	0.171837 (rank : 148)
Query Neighborhood Hits	554	Target Neighborhood Hits	458	Shared Neighborhood Hits	112
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

ATN1_HUMAN
θ value	0.0330416 (rank : 127)	NC score	0.166854 (rank : 154)
Query Neighborhood Hits	554	Target Neighborhood Hits	676	Shared Neighborhood Hits	131
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

CCNK_MOUSE
θ value	0.0330416 (rank : 128)	NC score	0.110282 (rank : 259)
Query Neighborhood Hits	554	Target Neighborhood Hits	350	Shared Neighborhood Hits	93
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

EPS8_HUMAN
θ value	0.0330416 (rank : 129)	NC score	0.192138 (rank : 127)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	109
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

FUBP2_HUMAN
θ value	0.0330416 (rank : 130)	NC score	0.046793 (rank : 663)
Query Neighborhood Hits	554	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q92945, O00301, Q9UNT5, Q9UQH5	Gene names	KHSRP, FUBP2
Domain Architecture
Description	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75).

MUC5B_HUMAN
θ value	0.0330416 (rank : 131)	NC score	0.070425 (rank : 439)
Query Neighborhood Hits	554	Target Neighborhood Hits	1020	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NOXO1_MOUSE
θ value	0.0330416 (rank : 132)	NC score	0.269074 (rank : 85)
Query Neighborhood Hits	554	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PACN2_HUMAN
θ value	0.0330416 (rank : 133)	NC score	0.333171 (rank : 56)
Query Neighborhood Hits	554	Target Neighborhood Hits	339	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PRP2_MOUSE
θ value	0.0330416 (rank : 134)	NC score	0.180161 (rank : 136)
Query Neighborhood Hits	554	Target Neighborhood Hits	347	Shared Neighborhood Hits	97
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SH3G1_HUMAN
θ value	0.0330416 (rank : 135)	NC score	0.352334 (rank : 44)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	158
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CK056_MOUSE
θ value	0.0431538 (rank : 136)	NC score	0.062603 (rank : 505)
Query Neighborhood Hits	554	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	Q3U2I3, Q3TWF5, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55	Gene names	Kiaa1759
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf56 homolog.

FMN1A_MOUSE
θ value	0.0431538 (rank : 137)	NC score	0.110643 (rank : 258)
Query Neighborhood Hits	554	Target Neighborhood Hits	423	Shared Neighborhood Hits	96
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	0.0431538 (rank : 138)	NC score	0.108808 (rank : 265)
Query Neighborhood Hits	554	Target Neighborhood Hits	447	Shared Neighborhood Hits	94
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

HCK_HUMAN
θ value	0.0431538 (rank : 139)	NC score	0.093180 (rank : 316)
Query Neighborhood Hits	554	Target Neighborhood Hits	1035	Shared Neighborhood Hits	170
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MYST3_HUMAN
θ value	0.0431538 (rank : 140)	NC score	0.074286 (rank : 400)
Query Neighborhood Hits	554	Target Neighborhood Hits	772	Shared Neighborhood Hits	88
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

PO6F2_MOUSE
θ value	0.0431538 (rank : 141)	NC score	0.069067 (rank : 450)
Query Neighborhood Hits	554	Target Neighborhood Hits	639	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

RUSC1_MOUSE
θ value	0.0431538 (rank : 142)	NC score	0.261603 (rank : 91)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SAPS1_HUMAN
θ value	0.0431538 (rank : 143)	NC score	0.136679 (rank : 202)
Query Neighborhood Hits	554	Target Neighborhood Hits	704	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SF01_MOUSE
θ value	0.0431538 (rank : 144)	NC score	0.119243 (rank : 238)
Query Neighborhood Hits	554	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SH3G3_MOUSE
θ value	0.0431538 (rank : 145)	NC score	0.368607 (rank : 35)
Query Neighborhood Hits	554	Target Neighborhood Hits	236	Shared Neighborhood Hits	160
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STAM1_HUMAN
θ value	0.0431538 (rank : 146)	NC score	0.341815 (rank : 50)
Query Neighborhood Hits	554	Target Neighborhood Hits	271	Shared Neighborhood Hits	176
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.0431538 (rank : 147)	NC score	0.341711 (rank : 51)
Query Neighborhood Hits	554	Target Neighborhood Hits	273	Shared Neighborhood Hits	179
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SYN1_HUMAN
θ value	0.0431538 (rank : 148)	NC score	0.109502 (rank : 263)
Query Neighborhood Hits	554	Target Neighborhood Hits	419	Shared Neighborhood Hits	103
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

ABI1_MOUSE
θ value	0.0563607 (rank : 149)	NC score	0.351008 (rank : 45)
Query Neighborhood Hits	554	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CSKI1_HUMAN
θ value	0.0563607 (rank : 150)	NC score	0.097176 (rank : 302)
Query Neighborhood Hits	554	Target Neighborhood Hits	997	Shared Neighborhood Hits	201
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ES8L2_HUMAN
θ value	0.0563607 (rank : 151)	NC score	0.198991 (rank : 117)
Query Neighborhood Hits	554	Target Neighborhood Hits	193	Shared Neighborhood Hits	134
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

PACN2_MOUSE
θ value	0.0563607 (rank : 152)	NC score	0.330043 (rank : 58)
Query Neighborhood Hits	554	Target Neighborhood Hits	382	Shared Neighborhood Hits	168
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	0.0563607 (rank : 153)	NC score	0.312725 (rank : 70)
Query Neighborhood Hits	554	Target Neighborhood Hits	385	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.0563607 (rank : 154)	NC score	0.315654 (rank : 68)
Query Neighborhood Hits	554	Target Neighborhood Hits	380	Shared Neighborhood Hits	153
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

STAC_HUMAN
θ value	0.0563607 (rank : 155)	NC score	0.340924 (rank : 52)
Query Neighborhood Hits	554	Target Neighborhood Hits	276	Shared Neighborhood Hits	160
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM2_MOUSE
θ value	0.0563607 (rank : 156)	NC score	0.340050 (rank : 54)
Query Neighborhood Hits	554	Target Neighborhood Hits	285	Shared Neighborhood Hits	177
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TAF4_HUMAN
θ value	0.0563607 (rank : 157)	NC score	0.139144 (rank : 193)
Query Neighborhood Hits	554	Target Neighborhood Hits	687	Shared Neighborhood Hits	129
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

WASIP_MOUSE
θ value	0.0563607 (rank : 158)	NC score	0.172792 (rank : 146)
Query Neighborhood Hits	554	Target Neighborhood Hits	392	Shared Neighborhood Hits	111
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ARHG6_HUMAN
θ value	0.0736092 (rank : 159)	NC score	0.315685 (rank : 67)
Query Neighborhood Hits	554	Target Neighborhood Hits	376	Shared Neighborhood Hits	162
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.0736092 (rank : 160)	NC score	0.321992 (rank : 62)
Query Neighborhood Hits	554	Target Neighborhood Hits	394	Shared Neighborhood Hits	163
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ATX2L_MOUSE
θ value	0.0736092 (rank : 161)	NC score	0.110136 (rank : 260)
Query Neighborhood Hits	554	Target Neighborhood Hits	401	Shared Neighborhood Hits	116
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

DDEF1_MOUSE
θ value	0.0736092 (rank : 162)	NC score	0.194504 (rank : 123)
Query Neighborhood Hits	554	Target Neighborhood Hits	592	Shared Neighborhood Hits	197
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GAK7_HUMAN
θ value	0.0736092 (rank : 163)	NC score	0.104754 (rank : 269)
Query Neighborhood Hits	554	Target Neighborhood Hits	90	Shared Neighborhood Hits	42
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

GAK8_HUMAN
θ value	0.0736092 (rank : 164)	NC score	0.105099 (rank : 268)
Query Neighborhood Hits	554	Target Neighborhood Hits	145	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GNAS1_MOUSE
θ value	0.0736092 (rank : 165)	NC score	0.068434 (rank : 456)
Query Neighborhood Hits	554	Target Neighborhood Hits	651	Shared Neighborhood Hits	162
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HNRPG_MOUSE
θ value	0.0736092 (rank : 166)	NC score	0.032812 (rank : 703)
Query Neighborhood Hits	554	Target Neighborhood Hits	223	Shared Neighborhood Hits	17
SwissProt Accessions	O35479	Gene names	Rbmx, Hnrnpg, Hnrpg, Rbmxp1, Rbmxrt
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome).

IRX5_HUMAN
θ value	0.0736092 (rank : 167)	NC score	0.035060 (rank : 694)
Query Neighborhood Hits	554	Target Neighborhood Hits	362	Shared Neighborhood Hits	48
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

NCF1_HUMAN
θ value	0.0736092 (rank : 168)	NC score	0.368229 (rank : 36)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	143
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PCLO_MOUSE
θ value	0.0736092 (rank : 169)	NC score	0.146478 (rank : 179)
Query Neighborhood Hits	554	Target Neighborhood Hits	2275	Shared Neighborhood Hits	317
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RHG04_HUMAN
θ value	0.0736092 (rank : 170)	NC score	0.219279 (rank : 111)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

S23IP_HUMAN
θ value	0.0736092 (rank : 171)	NC score	0.073941 (rank : 403)
Query Neighborhood Hits	554	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

SMCA4_HUMAN
θ value	0.0736092 (rank : 172)	NC score	0.039848 (rank : 682)
Query Neighborhood Hits	554	Target Neighborhood Hits	597	Shared Neighborhood Hits	86
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SNX18_MOUSE
θ value	0.0736092 (rank : 173)	NC score	0.250542 (rank : 97)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SOX13_HUMAN
θ value	0.0736092 (rank : 174)	NC score	0.098397 (rank : 297)
Query Neighborhood Hits	554	Target Neighborhood Hits	464	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SP7_MOUSE
θ value	0.0736092 (rank : 175)	NC score	0.001233 (rank : 812)
Query Neighborhood Hits	554	Target Neighborhood Hits	756	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VI67, Q8C5R3, Q8C6A7	Gene names	Sp7, Osx
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix) (C22).

ABI1_HUMAN
θ value	0.0961366 (rank : 176)	NC score	0.338951 (rank : 55)
Query Neighborhood Hits	554	Target Neighborhood Hits	257	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CO3A1_HUMAN
θ value	0.0961366 (rank : 177)	NC score	0.031704 (rank : 714)
Query Neighborhood Hits	554	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CRKL_MOUSE
θ value	0.0961366 (rank : 178)	NC score	0.310392 (rank : 71)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	167
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

HGS_MOUSE
θ value	0.0961366 (rank : 179)	NC score	0.102003 (rank : 279)
Query Neighborhood Hits	554	Target Neighborhood Hits	589	Shared Neighborhood Hits	125
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

K1688_MOUSE
θ value	0.0961366 (rank : 180)	NC score	0.072710 (rank : 414)
Query Neighborhood Hits	554	Target Neighborhood Hits	188	Shared Neighborhood Hits	56
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

LYN_HUMAN
θ value	0.0961366 (rank : 181)	NC score	0.082053 (rank : 358)
Query Neighborhood Hits	554	Target Neighborhood Hits	1022	Shared Neighborhood Hits	157
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MEGF9_HUMAN
θ value	0.0961366 (rank : 182)	NC score	0.025194 (rank : 743)
Query Neighborhood Hits	554	Target Neighborhood Hits	557	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

NCF1_MOUSE
θ value	0.0961366 (rank : 183)	NC score	0.355216 (rank : 42)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	150
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NEBL_HUMAN
θ value	0.0961366 (rank : 184)	NC score	0.261358 (rank : 94)
Query Neighborhood Hits	554	Target Neighborhood Hits	457	Shared Neighborhood Hits	149
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PACN1_HUMAN
θ value	0.0961366 (rank : 185)	NC score	0.324834 (rank : 61)
Query Neighborhood Hits	554	Target Neighborhood Hits	320	Shared Neighborhood Hits	160
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.0961366 (rank : 186)	NC score	0.326759 (rank : 59)
Query Neighborhood Hits	554	Target Neighborhood Hits	283	Shared Neighborhood Hits	158
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RCOR2_MOUSE
θ value	0.0961366 (rank : 187)	NC score	0.063100 (rank : 501)
Query Neighborhood Hits	554	Target Neighborhood Hits	107	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C796, Q9JMK4	Gene names	Rcor2
Domain Architecture	No domain graphic available
Description	REST corepressor 2 (M-CoREST).

RGS3_HUMAN
θ value	0.0961366 (rank : 188)	NC score	0.144895 (rank : 181)
Query Neighborhood Hits	554	Target Neighborhood Hits	1375	Shared Neighborhood Hits	259
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SNX18_HUMAN
θ value	0.0961366 (rank : 189)	NC score	0.240194 (rank : 105)
Query Neighborhood Hits	554	Target Neighborhood Hits	207	Shared Neighborhood Hits	126
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

TLN1_HUMAN
θ value	0.0961366 (rank : 190)	NC score	0.030609 (rank : 722)
Query Neighborhood Hits	554	Target Neighborhood Hits	218	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

ARI1A_HUMAN
θ value	0.125558 (rank : 191)	NC score	0.163404 (rank : 158)
Query Neighborhood Hits	554	Target Neighborhood Hits	787	Shared Neighborhood Hits	191
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

DIAP1_HUMAN
θ value	0.125558 (rank : 192)	NC score	0.074311 (rank : 399)
Query Neighborhood Hits	554	Target Neighborhood Hits	784	Shared Neighborhood Hits	94
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

DLG5_HUMAN
θ value	0.125558 (rank : 193)	NC score	0.056112 (rank : 577)
Query Neighborhood Hits	554	Target Neighborhood Hits	1088	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

FMN2_HUMAN
θ value	0.125558 (rank : 194)	NC score	0.112400 (rank : 252)
Query Neighborhood Hits	554	Target Neighborhood Hits	484	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

GAK10_HUMAN
θ value	0.125558 (rank : 195)	NC score	0.128832 (rank : 220)
Query Neighborhood Hits	554	Target Neighborhood Hits	289	Shared Neighborhood Hits	122
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

LYN_MOUSE
θ value	0.125558 (rank : 196)	NC score	0.081375 (rank : 363)
Query Neighborhood Hits	554	Target Neighborhood Hits	1023	Shared Neighborhood Hits	158
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MCF2L_MOUSE
θ value	0.125558 (rank : 197)	NC score	0.122416 (rank : 230)
Query Neighborhood Hits	554	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

NCF4_MOUSE
θ value	0.125558 (rank : 198)	NC score	0.346620 (rank : 49)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	137
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

RCOR2_HUMAN
θ value	0.125558 (rank : 199)	NC score	0.062404 (rank : 509)
Query Neighborhood Hits	554	Target Neighborhood Hits	114	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZ40, Q96FP3	Gene names	RCOR2
Domain Architecture	No domain graphic available
Description	REST corepressor 2.

S23IP_MOUSE
θ value	0.125558 (rank : 200)	NC score	0.120065 (rank : 236)
Query Neighborhood Hits	554	Target Neighborhood Hits	363	Shared Neighborhood Hits	125
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

SPEG_MOUSE
θ value	0.125558 (rank : 201)	NC score	0.043961 (rank : 668)
Query Neighborhood Hits	554	Target Neighborhood Hits	1959	Shared Neighborhood Hits	222
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CPSF6_HUMAN
θ value	0.163984 (rank : 202)	NC score	0.136217 (rank : 204)
Query Neighborhood Hits	554	Target Neighborhood Hits	359	Shared Neighborhood Hits	94
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	0.163984 (rank : 203)	NC score	0.136296 (rank : 203)
Query Neighborhood Hits	554	Target Neighborhood Hits	356	Shared Neighborhood Hits	94
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

EGR2_MOUSE
θ value	0.163984 (rank : 204)	NC score	-0.000053 (rank : 816)
Query Neighborhood Hits	554	Target Neighborhood Hits	745	Shared Neighborhood Hits	25
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

ENAH_MOUSE
θ value	0.163984 (rank : 205)	NC score	0.110999 (rank : 256)
Query Neighborhood Hits	554	Target Neighborhood Hits	919	Shared Neighborhood Hits	134
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

MKL1_MOUSE
θ value	0.163984 (rank : 206)	NC score	0.126132 (rank : 225)
Query Neighborhood Hits	554	Target Neighborhood Hits	667	Shared Neighborhood Hits	180
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

RHG26_HUMAN
θ value	0.163984 (rank : 207)	NC score	0.176418 (rank : 143)
Query Neighborhood Hits	554	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SON_MOUSE
θ value	0.163984 (rank : 208)	NC score	0.135003 (rank : 206)
Query Neighborhood Hits	554	Target Neighborhood Hits	957	Shared Neighborhood Hits	188
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

TAF6_MOUSE
θ value	0.163984 (rank : 209)	NC score	0.060962 (rank : 523)
Query Neighborhood Hits	554	Target Neighborhood Hits	110	Shared Neighborhood Hits	30
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

TENS4_MOUSE
θ value	0.163984 (rank : 210)	NC score	0.068768 (rank : 454)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

ATX2L_HUMAN
θ value	0.21417 (rank : 211)	NC score	0.111870 (rank : 254)
Query Neighborhood Hits	554	Target Neighborhood Hits	443	Shared Neighborhood Hits	130
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

DAZP1_HUMAN
θ value	0.21417 (rank : 212)	NC score	0.033386 (rank : 702)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	51
SwissProt Accessions	Q96EP5, Q96MJ3, Q9NRR9	Gene names	DAZAP1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

EP300_HUMAN
θ value	0.21417 (rank : 213)	NC score	0.127140 (rank : 221)
Query Neighborhood Hits	554	Target Neighborhood Hits	821	Shared Neighborhood Hits	171
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

ES8L2_MOUSE
θ value	0.21417 (rank : 214)	NC score	0.186166 (rank : 131)
Query Neighborhood Hits	554	Target Neighborhood Hits	169	Shared Neighborhood Hits	120
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FMN2_MOUSE
θ value	0.21417 (rank : 215)	NC score	0.101632 (rank : 281)
Query Neighborhood Hits	554	Target Neighborhood Hits	349	Shared Neighborhood Hits	103
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

PCLO_HUMAN
θ value	0.21417 (rank : 216)	NC score	0.138858 (rank : 194)
Query Neighborhood Hits	554	Target Neighborhood Hits	2046	Shared Neighborhood Hits	276
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PRR12_HUMAN
θ value	0.21417 (rank : 217)	NC score	0.141626 (rank : 190)
Query Neighborhood Hits	554	Target Neighborhood Hits	460	Shared Neighborhood Hits	112
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SPTA1_MOUSE
θ value	0.21417 (rank : 218)	NC score	0.153479 (rank : 169)
Query Neighborhood Hits	554	Target Neighborhood Hits	675	Shared Neighborhood Hits	155
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA3_MOUSE
θ value	0.21417 (rank : 219)	NC score	0.102501 (rank : 278)
Query Neighborhood Hits	554	Target Neighborhood Hits	74	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

STAC_MOUSE
θ value	0.21417 (rank : 220)	NC score	0.325523 (rank : 60)
Query Neighborhood Hits	554	Target Neighborhood Hits	268	Shared Neighborhood Hits	158
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TLN1_MOUSE
θ value	0.21417 (rank : 221)	NC score	0.029260 (rank : 725)
Query Neighborhood Hits	554	Target Neighborhood Hits	213	Shared Neighborhood Hits	12
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TRI66_HUMAN
θ value	0.21417 (rank : 222)	NC score	0.072519 (rank : 417)
Query Neighborhood Hits	554	Target Neighborhood Hits	479	Shared Neighborhood Hits	90
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

WASF3_HUMAN
θ value	0.21417 (rank : 223)	NC score	0.101709 (rank : 280)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

WASF3_MOUSE
θ value	0.21417 (rank : 224)	NC score	0.088324 (rank : 333)
Query Neighborhood Hits	554	Target Neighborhood Hits	188	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

ARHG4_HUMAN
θ value	0.279714 (rank : 225)	NC score	0.243372 (rank : 104)
Query Neighborhood Hits	554	Target Neighborhood Hits	242	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CRK_MOUSE
θ value	0.279714 (rank : 226)	NC score	0.315262 (rank : 69)
Query Neighborhood Hits	554	Target Neighborhood Hits	314	Shared Neighborhood Hits	175
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

HCK_MOUSE
θ value	0.279714 (rank : 227)	NC score	0.089320 (rank : 325)
Query Neighborhood Hits	554	Target Neighborhood Hits	1029	Shared Neighborhood Hits	168
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

K0310_HUMAN
θ value	0.279714 (rank : 228)	NC score	0.102755 (rank : 276)
Query Neighborhood Hits	554	Target Neighborhood Hits	420	Shared Neighborhood Hits	114
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MAGE1_HUMAN
θ value	0.279714 (rank : 229)	NC score	0.154330 (rank : 167)
Query Neighborhood Hits	554	Target Neighborhood Hits	1389	Shared Neighborhood Hits	267
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

RIMB2_MOUSE
θ value	0.279714 (rank : 230)	NC score	0.215437 (rank : 112)
Query Neighborhood Hits	554	Target Neighborhood Hits	246	Shared Neighborhood Hits	104
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

STAM2_HUMAN
θ value	0.279714 (rank : 231)	NC score	0.317187 (rank : 66)
Query Neighborhood Hits	554	Target Neighborhood Hits	288	Shared Neighborhood Hits	176
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

TTBK1_HUMAN
θ value	0.279714 (rank : 232)	NC score	0.038412 (rank : 685)
Query Neighborhood Hits	554	Target Neighborhood Hits	1058	Shared Neighborhood Hits	86
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

ANXA7_HUMAN
θ value	0.365318 (rank : 233)	NC score	0.028172 (rank : 732)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	41
SwissProt Accessions	P20073	Gene names	ANXA7, ANX7, SNX
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

BLK_HUMAN
θ value	0.365318 (rank : 234)	NC score	0.077110 (rank : 382)
Query Neighborhood Hits	554	Target Neighborhood Hits	994	Shared Neighborhood Hits	142
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CD44_MOUSE
θ value	0.365318 (rank : 235)	NC score	0.034349 (rank : 698)
Query Neighborhood Hits	554	Target Neighborhood Hits	64	Shared Neighborhood Hits	12
SwissProt Accessions	P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8	Gene names	Cd44, Ly-24
Domain Architecture
Description	CD44 antigen precursor (Phagocytic glycoprotein 1) (PGP-1) (HUTCH-I) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen Ly-24).

CN032_HUMAN
θ value	0.365318 (rank : 236)	NC score	0.115295 (rank : 244)
Query Neighborhood Hits	554	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

ES8L3_MOUSE
θ value	0.365318 (rank : 237)	NC score	0.219518 (rank : 110)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	128
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HRX_HUMAN
θ value	0.365318 (rank : 238)	NC score	0.072459 (rank : 419)
Query Neighborhood Hits	554	Target Neighborhood Hits	825	Shared Neighborhood Hits	94
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IF4G1_MOUSE
θ value	0.365318 (rank : 239)	NC score	0.082563 (rank : 356)
Query Neighborhood Hits	554	Target Neighborhood Hits	534	Shared Neighborhood Hits	140
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

K1802_MOUSE
θ value	0.365318 (rank : 240)	NC score	0.132181 (rank : 211)
Query Neighborhood Hits	554	Target Neighborhood Hits	1596	Shared Neighborhood Hits	250
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MGR1_MOUSE
θ value	0.365318 (rank : 241)	NC score	0.032286 (rank : 707)
Query Neighborhood Hits	554	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	P97772, Q6AXG4, Q9EPV6	Gene names	Grm1, Gprc1a, Mglur1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

MK07_MOUSE
θ value	0.365318 (rank : 242)	NC score	0.024151 (rank : 745)
Query Neighborhood Hits	554	Target Neighborhood Hits	1054	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MLL3_MOUSE
θ value	0.365318 (rank : 243)	NC score	0.151709 (rank : 173)
Query Neighborhood Hits	554	Target Neighborhood Hits	1399	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MUC7_HUMAN
θ value	0.365318 (rank : 244)	NC score	0.122907 (rank : 229)
Query Neighborhood Hits	554	Target Neighborhood Hits	538	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCF2_HUMAN
θ value	0.365318 (rank : 245)	NC score	0.396532 (rank : 22)
Query Neighborhood Hits	554	Target Neighborhood Hits	229	Shared Neighborhood Hits	149
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NEBU_HUMAN
θ value	0.365318 (rank : 246)	NC score	0.227418 (rank : 108)
Query Neighborhood Hits	554	Target Neighborhood Hits	420	Shared Neighborhood Hits	151
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PCD15_MOUSE
θ value	0.365318 (rank : 247)	NC score	0.012374 (rank : 779)
Query Neighborhood Hits	554	Target Neighborhood Hits	262	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PJ1	Gene names	Pcdh15
Domain Architecture
Description	Protocadherin-15 precursor.

PRB4S_HUMAN
θ value	0.365318 (rank : 248)	NC score	0.141959 (rank : 186)
Query Neighborhood Hits	554	Target Neighborhood Hits	330	Shared Neighborhood Hits	91
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PTN23_HUMAN
θ value	0.365318 (rank : 249)	NC score	0.062232 (rank : 511)
Query Neighborhood Hits	554	Target Neighborhood Hits	646	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RIMB2_HUMAN
θ value	0.365318 (rank : 250)	NC score	0.223962 (rank : 109)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	116
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

VAV3_HUMAN
θ value	0.365318 (rank : 251)	NC score	0.238401 (rank : 106)
Query Neighborhood Hits	554	Target Neighborhood Hits	398	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

WBP2_MOUSE
θ value	0.365318 (rank : 252)	NC score	0.070629 (rank : 436)
Query Neighborhood Hits	554	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	P97765	Gene names	Wbp2
Domain Architecture
Description	WW domain-binding protein 2 (WBP-2).

WDR33_HUMAN
θ value	0.365318 (rank : 253)	NC score	0.046061 (rank : 665)
Query Neighborhood Hits	554	Target Neighborhood Hits	638	Shared Neighborhood Hits	93
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

BSN_MOUSE
θ value	0.47712 (rank : 254)	NC score	0.158292 (rank : 163)
Query Neighborhood Hits	554	Target Neighborhood Hits	2057	Shared Neighborhood Hits	292
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

DACH1_HUMAN
θ value	0.47712 (rank : 255)	NC score	0.032791 (rank : 704)
Query Neighborhood Hits	554	Target Neighborhood Hits	214	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

EP400_MOUSE
θ value	0.47712 (rank : 256)	NC score	0.065812 (rank : 476)
Query Neighborhood Hits	554	Target Neighborhood Hits	592	Shared Neighborhood Hits	128
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

EPN1_HUMAN
θ value	0.47712 (rank : 257)	NC score	0.060758 (rank : 524)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

ERF_HUMAN
θ value	0.47712 (rank : 258)	NC score	0.031799 (rank : 711)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

FA47B_HUMAN
θ value	0.47712 (rank : 259)	NC score	0.166231 (rank : 156)
Query Neighborhood Hits	554	Target Neighborhood Hits	431	Shared Neighborhood Hits	158
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

LPP_MOUSE
θ value	0.47712 (rank : 260)	NC score	0.047973 (rank : 658)
Query Neighborhood Hits	554	Target Neighborhood Hits	247	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

MACF1_MOUSE
θ value	0.47712 (rank : 261)	NC score	0.022888 (rank : 750)
Query Neighborhood Hits	554	Target Neighborhood Hits	1313	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

NCOA6_HUMAN
θ value	0.47712 (rank : 262)	NC score	0.194771 (rank : 122)
Query Neighborhood Hits	554	Target Neighborhood Hits	1202	Shared Neighborhood Hits	280
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

OBF1_HUMAN
θ value	0.47712 (rank : 263)	NC score	0.109552 (rank : 262)
Query Neighborhood Hits	554	Target Neighborhood Hits	203	Shared Neighborhood Hits	103
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

PTK6_HUMAN
θ value	0.47712 (rank : 264)	NC score	0.073828 (rank : 405)
Query Neighborhood Hits	554	Target Neighborhood Hits	1020	Shared Neighborhood Hits	156
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

R3HD1_HUMAN
θ value	0.47712 (rank : 265)	NC score	0.077778 (rank : 379)
Query Neighborhood Hits	554	Target Neighborhood Hits	203	Shared Neighborhood Hits	63
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

RFX1_MOUSE
θ value	0.47712 (rank : 266)	NC score	0.042133 (rank : 675)
Query Neighborhood Hits	554	Target Neighborhood Hits	181	Shared Neighborhood Hits	50
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

SOX13_MOUSE
θ value	0.47712 (rank : 267)	NC score	0.085082 (rank : 346)
Query Neighborhood Hits	554	Target Neighborhood Hits	495	Shared Neighborhood Hits	128
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

TAF6_HUMAN
θ value	0.47712 (rank : 268)	NC score	0.056025 (rank : 579)
Query Neighborhood Hits	554	Target Neighborhood Hits	127	Shared Neighborhood Hits	29
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

ZN598_MOUSE
θ value	0.47712 (rank : 269)	NC score	0.041828 (rank : 677)
Query Neighborhood Hits	554	Target Neighborhood Hits	255	Shared Neighborhood Hits	25
SwissProt Accessions	Q80YR4, Q6KAT0, Q8R3S1	Gene names	Znf598, Zfp598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

BTK_HUMAN
θ value	0.62314 (rank : 270)	NC score	0.093861 (rank : 314)
Query Neighborhood Hits	554	Target Neighborhood Hits	1026	Shared Neighborhood Hits	173
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DAZL_MOUSE
θ value	0.62314 (rank : 271)	NC score	0.024326 (rank : 744)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q64368	Gene names	Dazl, Dazl1, Dazla
Domain Architecture
Description	Deleted in azoospermia-like (DAZ-like autosomal) (Deleted in azoospermia-like 1).

EMIL2_HUMAN
θ value	0.62314 (rank : 272)	NC score	0.019963 (rank : 756)
Query Neighborhood Hits	554	Target Neighborhood Hits	573	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

FGR_HUMAN
θ value	0.62314 (rank : 273)	NC score	0.098495 (rank : 296)
Query Neighborhood Hits	554	Target Neighborhood Hits	1067	Shared Neighborhood Hits	169
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HNRPG_HUMAN
θ value	0.62314 (rank : 274)	NC score	0.026930 (rank : 737)
Query Neighborhood Hits	554	Target Neighborhood Hits	245	Shared Neighborhood Hits	20
SwissProt Accessions	P38159, Q5JQ67, Q969R3	Gene names	RBMX, HNRPG, RBMXP1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome) (Glycoprotein p43).

ITF2_HUMAN
θ value	0.62314 (rank : 275)	NC score	0.034190 (rank : 699)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

MYBPH_HUMAN
θ value	0.62314 (rank : 276)	NC score	0.028779 (rank : 728)
Query Neighborhood Hits	554	Target Neighborhood Hits	256	Shared Neighborhood Hits	15
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

NCOA6_MOUSE
θ value	0.62314 (rank : 277)	NC score	0.171966 (rank : 147)
Query Neighborhood Hits	554	Target Neighborhood Hits	1076	Shared Neighborhood Hits	263
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RCOR3_MOUSE
θ value	0.62314 (rank : 278)	NC score	0.055258 (rank : 587)
Query Neighborhood Hits	554	Target Neighborhood Hits	110	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PGA0	Gene names	Rcor3
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

RIMB1_MOUSE
θ value	0.62314 (rank : 279)	NC score	0.134730 (rank : 207)
Query Neighborhood Hits	554	Target Neighborhood Hits	1376	Shared Neighborhood Hits	208
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUSC2_HUMAN
θ value	0.62314 (rank : 280)	NC score	0.147120 (rank : 177)
Query Neighborhood Hits	554	Target Neighborhood Hits	205	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SAM68_HUMAN
θ value	0.62314 (rank : 281)	NC score	0.042873 (rank : 673)
Query Neighborhood Hits	554	Target Neighborhood Hits	68	Shared Neighborhood Hits	16
SwissProt Accessions	Q07666, Q6PJX7, Q8NB97, Q99760	Gene names	KHDRBS1, SAM68
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

TXND2_HUMAN
θ value	0.62314 (rank : 282)	NC score	0.098005 (rank : 299)
Query Neighborhood Hits	554	Target Neighborhood Hits	793	Shared Neighborhood Hits	111
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

VAV3_MOUSE
θ value	0.62314 (rank : 283)	NC score	0.231734 (rank : 107)
Query Neighborhood Hits	554	Target Neighborhood Hits	404	Shared Neighborhood Hits	168
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

WBP2_HUMAN
θ value	0.62314 (rank : 284)	NC score	0.074231 (rank : 401)
Query Neighborhood Hits	554	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q969T9, O95638	Gene names	WBP2
Domain Architecture
Description	WW domain-binding protein 2 (WBP-2).

WNK4_HUMAN
θ value	0.62314 (rank : 285)	NC score	0.028604 (rank : 729)
Query Neighborhood Hits	554	Target Neighborhood Hits	1043	Shared Neighborhood Hits	89
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ACK1_MOUSE
θ value	0.813845 (rank : 286)	NC score	0.055026 (rank : 594)
Query Neighborhood Hits	554	Target Neighborhood Hits	1080	Shared Neighborhood Hits	174
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ANX11_MOUSE
θ value	0.813845 (rank : 287)	NC score	0.035191 (rank : 693)
Query Neighborhood Hits	554	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

CBP_HUMAN
θ value	0.813845 (rank : 288)	NC score	0.130087 (rank : 218)
Query Neighborhood Hits	554	Target Neighborhood Hits	941	Shared Neighborhood Hits	200
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	0.813845 (rank : 289)	NC score	0.138438 (rank : 196)
Query Neighborhood Hits	554	Target Neighborhood Hits	1051	Shared Neighborhood Hits	220
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DEK_MOUSE
θ value	0.813845 (rank : 290)	NC score	0.025716 (rank : 742)
Query Neighborhood Hits	554	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TNV0, Q80VC5, Q8BZV6	Gene names	Dek
Domain Architecture	No domain graphic available
Description	Protein DEK.

GAK1_HUMAN
θ value	0.813845 (rank : 291)	NC score	0.114998 (rank : 245)
Query Neighborhood Hits	554	Target Neighborhood Hits	268	Shared Neighborhood Hits	114
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PDLI7_HUMAN
θ value	0.813845 (rank : 292)	NC score	0.062145 (rank : 513)
Query Neighborhood Hits	554	Target Neighborhood Hits	547	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PLS1_MOUSE
θ value	0.813845 (rank : 293)	NC score	0.041202 (rank : 681)
Query Neighborhood Hits	554	Target Neighborhood Hits	58	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JJ00, O54730, O54731, Q9D1F8	Gene names	Plscr1, Tra1b, Tras1
Domain Architecture
Description	Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Transplantability-associated protein 1) (TRA1) (NOR1).

PO6F2_HUMAN
θ value	0.813845 (rank : 294)	NC score	0.054113 (rank : 605)
Query Neighborhood Hits	554	Target Neighborhood Hits	618	Shared Neighborhood Hits	96
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

RPB1_HUMAN
θ value	0.813845 (rank : 295)	NC score	0.070764 (rank : 434)
Query Neighborhood Hits	554	Target Neighborhood Hits	362	Shared Neighborhood Hits	69
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	0.813845 (rank : 296)	NC score	0.071092 (rank : 429)
Query Neighborhood Hits	554	Target Neighborhood Hits	363	Shared Neighborhood Hits	69
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SC24D_HUMAN
θ value	0.813845 (rank : 297)	NC score	0.070946 (rank : 432)
Query Neighborhood Hits	554	Target Neighborhood Hits	173	Shared Neighborhood Hits	55
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

SRC_HUMAN
θ value	0.813845 (rank : 298)	NC score	0.099306 (rank : 291)
Query Neighborhood Hits	554	Target Neighborhood Hits	1058	Shared Neighborhood Hits	179
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SSBP3_HUMAN
θ value	0.813845 (rank : 299)	NC score	0.056335 (rank : 570)
Query Neighborhood Hits	554	Target Neighborhood Hits	132	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BWW4, Q9BTM0, Q9BWW3	Gene names	SSBP3, SSDP, SSDP1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein).

SSBP3_MOUSE
θ value	0.813845 (rank : 300)	NC score	0.056335 (rank : 571)
Query Neighborhood Hits	554	Target Neighborhood Hits	132	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D032, Q99LC6, Q9EQP3	Gene names	Ssbp3, Last, Ssdp1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein) (Lck-associated signal transducer).

WASF1_MOUSE
θ value	0.813845 (rank : 301)	NC score	0.103664 (rank : 274)
Query Neighborhood Hits	554	Target Neighborhood Hits	261	Shared Neighborhood Hits	79
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

YES_HUMAN
θ value	0.813845 (rank : 302)	NC score	0.098929 (rank : 295)
Query Neighborhood Hits	554	Target Neighborhood Hits	1059	Shared Neighborhood Hits	171
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.813845 (rank : 303)	NC score	0.099552 (rank : 288)
Query Neighborhood Hits	554	Target Neighborhood Hits	1052	Shared Neighborhood Hits	171
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YLPM1_MOUSE
θ value	0.813845 (rank : 304)	NC score	0.126789 (rank : 223)
Query Neighborhood Hits	554	Target Neighborhood Hits	505	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ALMS1_HUMAN
θ value	1.06291 (rank : 305)	NC score	0.052799 (rank : 621)
Query Neighborhood Hits	554	Target Neighborhood Hits	356	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

CN092_MOUSE
θ value	1.06291 (rank : 306)	NC score	0.048297 (rank : 657)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

ENAM_MOUSE
θ value	1.06291 (rank : 307)	NC score	0.075796 (rank : 390)
Query Neighborhood Hits	554	Target Neighborhood Hits	229	Shared Neighborhood Hits	62
SwissProt Accessions	O55196	Gene names	Enam
Domain Architecture	No domain graphic available
Description	Enamelin precursor.

EPN1_MOUSE
θ value	1.06291 (rank : 308)	NC score	0.058494 (rank : 546)
Query Neighborhood Hits	554	Target Neighborhood Hits	240	Shared Neighborhood Hits	72
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

F113A_HUMAN
θ value	1.06291 (rank : 309)	NC score	0.031350 (rank : 717)
Query Neighborhood Hits	554	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1Q7, Q5JUA5, Q5JUA6, Q6PK19, Q86WF5, Q96CG7, Q9H1Q6, Q9H6D1	Gene names	FAM113A, C20orf81
Domain Architecture	No domain graphic available
Description	Protein FAM113A (Sarcoma antigen NY-SAR-23).

FGD1_HUMAN
θ value	1.06291 (rank : 310)	NC score	0.080493 (rank : 368)
Query Neighborhood Hits	554	Target Neighborhood Hits	367	Shared Neighborhood Hits	90
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FRK_HUMAN
θ value	1.06291 (rank : 311)	NC score	0.083333 (rank : 353)
Query Neighborhood Hits	554	Target Neighborhood Hits	1058	Shared Neighborhood Hits	173
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HTF4_MOUSE
θ value	1.06291 (rank : 312)	NC score	0.034695 (rank : 696)
Query Neighborhood Hits	554	Target Neighborhood Hits	153	Shared Neighborhood Hits	20
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

IRS2_MOUSE
θ value	1.06291 (rank : 313)	NC score	0.042721 (rank : 674)
Query Neighborhood Hits	554	Target Neighborhood Hits	248	Shared Neighborhood Hits	51
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

MKL1_HUMAN
θ value	1.06291 (rank : 314)	NC score	0.048394 (rank : 655)
Query Neighborhood Hits	554	Target Neighborhood Hits	232	Shared Neighborhood Hits	44
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

MUCDL_HUMAN
θ value	1.06291 (rank : 315)	NC score	0.113126 (rank : 249)
Query Neighborhood Hits	554	Target Neighborhood Hits	777	Shared Neighborhood Hits	181
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

PELP1_HUMAN
θ value	1.06291 (rank : 316)	NC score	0.071239 (rank : 427)
Query Neighborhood Hits	554	Target Neighborhood Hits	596	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PELP1_MOUSE
θ value	1.06291 (rank : 317)	NC score	0.119579 (rank : 237)
Query Neighborhood Hits	554	Target Neighborhood Hits	709	Shared Neighborhood Hits	153
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PGCB_HUMAN
θ value	1.06291 (rank : 318)	NC score	0.011587 (rank : 781)
Query Neighborhood Hits	554	Target Neighborhood Hits	478	Shared Neighborhood Hits	32
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

RIMB1_HUMAN
θ value	1.06291 (rank : 319)	NC score	0.155672 (rank : 166)
Query Neighborhood Hits	554	Target Neighborhood Hits	1479	Shared Neighborhood Hits	219
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRGP2_MOUSE
θ value	1.06291 (rank : 320)	NC score	0.171263 (rank : 149)
Query Neighborhood Hits	554	Target Neighborhood Hits	324	Shared Neighborhood Hits	146
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SYP2L_MOUSE
θ value	1.06291 (rank : 321)	NC score	0.053704 (rank : 612)
Query Neighborhood Hits	554	Target Neighborhood Hits	289	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

VAV2_HUMAN
θ value	1.06291 (rank : 322)	NC score	0.249099 (rank : 99)
Query Neighborhood Hits	554	Target Neighborhood Hits	453	Shared Neighborhood Hits	168
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	1.06291 (rank : 323)	NC score	0.249502 (rank : 98)
Query Neighborhood Hits	554	Target Neighborhood Hits	456	Shared Neighborhood Hits	171
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

WASF2_MOUSE
θ value	1.06291 (rank : 324)	NC score	0.118302 (rank : 240)
Query Neighborhood Hits	554	Target Neighborhood Hits	315	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WHRN_MOUSE
θ value	1.06291 (rank : 325)	NC score	0.043718 (rank : 669)
Query Neighborhood Hits	554	Target Neighborhood Hits	412	Shared Neighborhood Hits	82
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

CSKI2_HUMAN
θ value	1.38821 (rank : 326)	NC score	0.065154 (rank : 483)
Query Neighborhood Hits	554	Target Neighborhood Hits	747	Shared Neighborhood Hits	118
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DAZP1_MOUSE
θ value	1.38821 (rank : 327)	NC score	0.030792 (rank : 721)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JII5	Gene names	Dazap1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

DYN2_MOUSE
θ value	1.38821 (rank : 328)	NC score	0.016756 (rank : 765)
Query Neighborhood Hits	554	Target Neighborhood Hits	104	Shared Neighborhood Hits	19
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

ERF_MOUSE
θ value	1.38821 (rank : 329)	NC score	0.027093 (rank : 736)
Query Neighborhood Hits	554	Target Neighborhood Hits	160	Shared Neighborhood Hits	37
SwissProt Accessions	P70459	Gene names	Erf
Domain Architecture
Description	ETS domain-containing transcription factor ERF.

ESX1L_HUMAN
θ value	1.38821 (rank : 330)	NC score	0.026858 (rank : 738)
Query Neighborhood Hits	554	Target Neighborhood Hits	498	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

FYN_HUMAN
θ value	1.38821 (rank : 331)	NC score	0.097781 (rank : 300)
Query Neighborhood Hits	554	Target Neighborhood Hits	1078	Shared Neighborhood Hits	175
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	1.38821 (rank : 332)	NC score	0.099725 (rank : 286)
Query Neighborhood Hits	554	Target Neighborhood Hits	1073	Shared Neighborhood Hits	175
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

NFRKB_MOUSE
θ value	1.38821 (rank : 333)	NC score	0.086432 (rank : 340)
Query Neighborhood Hits	554	Target Neighborhood Hits	393	Shared Neighborhood Hits	100
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

RBM16_HUMAN
θ value	1.38821 (rank : 334)	NC score	0.052687 (rank : 624)
Query Neighborhood Hits	554	Target Neighborhood Hits	300	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

RUSC2_MOUSE
θ value	1.38821 (rank : 335)	NC score	0.138472 (rank : 195)
Query Neighborhood Hits	554	Target Neighborhood Hits	305	Shared Neighborhood Hits	114
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SAPS1_MOUSE
θ value	1.38821 (rank : 336)	NC score	0.038763 (rank : 684)
Query Neighborhood Hits	554	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

SIN3A_MOUSE
θ value	1.38821 (rank : 337)	NC score	0.043657 (rank : 670)
Query Neighborhood Hits	554	Target Neighborhood Hits	169	Shared Neighborhood Hits	41
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SMAD5_MOUSE
θ value	1.38821 (rank : 338)	NC score	0.014016 (rank : 771)
Query Neighborhood Hits	554	Target Neighborhood Hits	74	Shared Neighborhood Hits	22
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

SYN1_MOUSE
θ value	1.38821 (rank : 339)	NC score	0.099455 (rank : 289)
Query Neighborhood Hits	554	Target Neighborhood Hits	363	Shared Neighborhood Hits	92
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

UBQL4_HUMAN
θ value	1.38821 (rank : 340)	NC score	0.020864 (rank : 754)
Query Neighborhood Hits	554	Target Neighborhood Hits	117	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NRR5, Q9BR98, Q9UHX4	Gene names	UBQLN4, C1orf6, UBIN
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

ZN687_HUMAN
θ value	1.38821 (rank : 341)	NC score	0.036212 (rank : 691)
Query Neighborhood Hits	554	Target Neighborhood Hits	1244	Shared Neighborhood Hits	182
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ZYX_HUMAN
θ value	1.38821 (rank : 342)	NC score	0.063335 (rank : 498)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

AAK1_HUMAN
θ value	1.81305 (rank : 343)	NC score	0.046315 (rank : 664)
Query Neighborhood Hits	554	Target Neighborhood Hits	1077	Shared Neighborhood Hits	150
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ANM2_HUMAN
θ value	1.81305 (rank : 344)	NC score	0.169979 (rank : 151)
Query Neighborhood Hits	554	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	1.81305 (rank : 345)	NC score	0.163140 (rank : 159)
Query Neighborhood Hits	554	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

AP2A_MOUSE
θ value	1.81305 (rank : 346)	NC score	0.019067 (rank : 759)
Query Neighborhood Hits	554	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	P34056, Q60740, Q60741, Q60742, Q60743, Q62067, Q62068, Q62069, Q91VX0, Q9CRY4	Gene names	Tfap2a, Ap2tf, Tcfap2a
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (Activator protein 2) (AP-2).

ATBF1_MOUSE
θ value	1.81305 (rank : 347)	NC score	0.028055 (rank : 733)
Query Neighborhood Hits	554	Target Neighborhood Hits	1841	Shared Neighborhood Hits	133
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BTK_MOUSE
θ value	1.81305 (rank : 348)	NC score	0.086512 (rank : 338)
Query Neighborhood Hits	554	Target Neighborhood Hits	1017	Shared Neighborhood Hits	165
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CRTC1_HUMAN
θ value	1.81305 (rank : 349)	NC score	0.093385 (rank : 315)
Query Neighborhood Hits	554	Target Neighborhood Hits	319	Shared Neighborhood Hits	108
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

CSKI2_MOUSE
θ value	1.81305 (rank : 350)	NC score	0.072423 (rank : 420)
Query Neighborhood Hits	554	Target Neighborhood Hits	812	Shared Neighborhood Hits	152
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

FMNL_MOUSE
θ value	1.81305 (rank : 351)	NC score	0.072949 (rank : 410)
Query Neighborhood Hits	554	Target Neighborhood Hits	428	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

ITF2_MOUSE
θ value	1.81305 (rank : 352)	NC score	0.030914 (rank : 720)
Query Neighborhood Hits	554	Target Neighborhood Hits	154	Shared Neighborhood Hits	11
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

LASP1_HUMAN
θ value	1.81305 (rank : 353)	NC score	0.264243 (rank : 88)
Query Neighborhood Hits	554	Target Neighborhood Hits	293	Shared Neighborhood Hits	148
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	1.81305 (rank : 354)	NC score	0.261381 (rank : 93)
Query Neighborhood Hits	554	Target Neighborhood Hits	297	Shared Neighborhood Hits	146
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MATK_HUMAN
θ value	1.81305 (rank : 355)	NC score	0.052075 (rank : 633)
Query Neighborhood Hits	554	Target Neighborhood Hits	954	Shared Neighborhood Hits	86
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	1.81305 (rank : 356)	NC score	0.051302 (rank : 642)
Query Neighborhood Hits	554	Target Neighborhood Hits	952	Shared Neighborhood Hits	90
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MLL4_HUMAN
θ value	1.81305 (rank : 357)	NC score	0.090773 (rank : 319)
Query Neighborhood Hits	554	Target Neighborhood Hits	722	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MNT_HUMAN
θ value	1.81305 (rank : 358)	NC score	0.103933 (rank : 272)
Query Neighborhood Hits	554	Target Neighborhood Hits	496	Shared Neighborhood Hits	128
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYO15_MOUSE
θ value	1.81305 (rank : 359)	NC score	0.060628 (rank : 525)
Query Neighborhood Hits	554	Target Neighborhood Hits	467	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NACAM_MOUSE
θ value	1.81305 (rank : 360)	NC score	0.180014 (rank : 138)
Query Neighborhood Hits	554	Target Neighborhood Hits	1866	Shared Neighborhood Hits	296
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCF4_HUMAN
θ value	1.81305 (rank : 361)	NC score	0.317700 (rank : 64)
Query Neighborhood Hits	554	Target Neighborhood Hits	161	Shared Neighborhood Hits	124
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NOXO1_HUMAN
θ value	1.81305 (rank : 362)	NC score	0.203946 (rank : 116)
Query Neighborhood Hits	554	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PDC6I_MOUSE
θ value	1.81305 (rank : 363)	NC score	0.068197 (rank : 457)
Query Neighborhood Hits	554	Target Neighborhood Hits	275	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

PLS3_MOUSE
θ value	1.81305 (rank : 364)	NC score	0.031777 (rank : 713)
Query Neighborhood Hits	554	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIZ9	Gene names	Plscr3
Domain Architecture
Description	Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3).

REXO1_HUMAN
θ value	1.81305 (rank : 365)	NC score	0.032463 (rank : 705)
Query Neighborhood Hits	554	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

RTP3_MOUSE
θ value	1.81305 (rank : 366)	NC score	0.089223 (rank : 326)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	111
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SET1A_HUMAN
θ value	1.81305 (rank : 367)	NC score	0.080472 (rank : 369)
Query Neighborhood Hits	554	Target Neighborhood Hits	690	Shared Neighborhood Hits	99
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SHC1_HUMAN
θ value	1.81305 (rank : 368)	NC score	0.067623 (rank : 464)
Query Neighborhood Hits	554	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

TEAD2_MOUSE
θ value	1.81305 (rank : 369)	NC score	0.012878 (rank : 777)
Query Neighborhood Hits	554	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P48301, Q62297	Gene names	Tead2, Etdf, Etf, Tef4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) (Embryonic TEA domain-containing factor) (ETF) (ETEF-1).

WASF1_HUMAN
θ value	1.81305 (rank : 370)	NC score	0.099832 (rank : 284)
Query Neighborhood Hits	554	Target Neighborhood Hits	260	Shared Neighborhood Hits	79
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF2_HUMAN
θ value	1.81305 (rank : 371)	NC score	0.111403 (rank : 255)
Query Neighborhood Hits	554	Target Neighborhood Hits	280	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

ACK1_HUMAN
θ value	2.36792 (rank : 372)	NC score	0.057133 (rank : 559)
Query Neighborhood Hits	554	Target Neighborhood Hits	1140	Shared Neighborhood Hits	188
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ANTR1_MOUSE
θ value	2.36792 (rank : 373)	NC score	0.055184 (rank : 590)
Query Neighborhood Hits	554	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

AP2A_HUMAN
θ value	2.36792 (rank : 374)	NC score	0.017744 (rank : 764)
Query Neighborhood Hits	554	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P05549, Q13777	Gene names	TFAP2A, AP2TF, TFAP2
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (AP-2 transcription factor) (Activator protein 2) (AP-2).

CK024_HUMAN
θ value	2.36792 (rank : 375)	NC score	0.124492 (rank : 228)
Query Neighborhood Hits	554	Target Neighborhood Hits	408	Shared Neighborhood Hits	135
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CN032_MOUSE
θ value	2.36792 (rank : 376)	NC score	0.112444 (rank : 251)
Query Neighborhood Hits	554	Target Neighborhood Hits	233	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

CN092_HUMAN
θ value	2.36792 (rank : 377)	NC score	0.033963 (rank : 701)
Query Neighborhood Hits	554	Target Neighborhood Hits	143	Shared Neighborhood Hits	29
SwissProt Accessions	O94842	Gene names	C14orf92, KIAA0737
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

DIAP1_MOUSE
θ value	2.36792 (rank : 378)	NC score	0.060970 (rank : 522)
Query Neighborhood Hits	554	Target Neighborhood Hits	839	Shared Neighborhood Hits	88
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

FOXJ2_HUMAN
θ value	2.36792 (rank : 379)	NC score	0.028384 (rank : 730)
Query Neighborhood Hits	554	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

FOXJ3_HUMAN
θ value	2.36792 (rank : 380)	NC score	0.009810 (rank : 788)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

FRS3_MOUSE
θ value	2.36792 (rank : 381)	NC score	0.036935 (rank : 690)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	44
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

HDGF_HUMAN
θ value	2.36792 (rank : 382)	NC score	0.020437 (rank : 755)
Query Neighborhood Hits	554	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	P51858, Q5SZ09	Gene names	HDGF, HMG1L2
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF) (High-mobility group protein 1- like 2) (HMG-1L2).

IGHD_HUMAN
θ value	2.36792 (rank : 383)	NC score	0.011582 (rank : 782)
Query Neighborhood Hits	554	Target Neighborhood Hits	194	Shared Neighborhood Hits	11
SwissProt Accessions	P01880	Gene names	IGHD
Domain Architecture	No domain graphic available
Description	Ig delta chain C region.

KCNN3_HUMAN
θ value	2.36792 (rank : 384)	NC score	0.018626 (rank : 760)
Query Neighborhood Hits	554	Target Neighborhood Hits	216	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

LCP2_HUMAN
θ value	2.36792 (rank : 385)	NC score	0.161428 (rank : 162)
Query Neighborhood Hits	554	Target Neighborhood Hits	531	Shared Neighborhood Hits	184
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PER1_HUMAN
θ value	2.36792 (rank : 386)	NC score	0.037147 (rank : 689)
Query Neighborhood Hits	554	Target Neighborhood Hits	215	Shared Neighborhood Hits	46
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PHLA1_HUMAN
θ value	2.36792 (rank : 387)	NC score	0.054034 (rank : 607)
Query Neighborhood Hits	554	Target Neighborhood Hits	121	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

PHLA1_MOUSE
θ value	2.36792 (rank : 388)	NC score	0.048992 (rank : 654)
Query Neighborhood Hits	554	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	Q62392, Q3TY48, Q3UG87	Gene names	Phlda1, Tdag51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Proline- and glutamine-rich protein) (PQR protein).

PRRT3_HUMAN
θ value	2.36792 (rank : 389)	NC score	0.205341 (rank : 113)
Query Neighborhood Hits	554	Target Neighborhood Hits	998	Shared Neighborhood Hits	254
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RFX1_HUMAN
θ value	2.36792 (rank : 390)	NC score	0.058940 (rank : 537)
Query Neighborhood Hits	554	Target Neighborhood Hits	256	Shared Neighborhood Hits	84
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SRC_MOUSE
θ value	2.36792 (rank : 391)	NC score	0.085526 (rank : 343)
Query Neighborhood Hits	554	Target Neighborhood Hits	1033	Shared Neighborhood Hits	168
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP2_HUMAN
θ value	2.36792 (rank : 392)	NC score	0.165919 (rank : 157)
Query Neighborhood Hits	554	Target Neighborhood Hits	331	Shared Neighborhood Hits	145
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

WIRE_HUMAN
θ value	2.36792 (rank : 393)	NC score	0.120331 (rank : 234)
Query Neighborhood Hits	554	Target Neighborhood Hits	329	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ZO2_MOUSE
θ value	2.36792 (rank : 394)	NC score	0.023373 (rank : 747)
Query Neighborhood Hits	554	Target Neighborhood Hits	296	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

AB1IP_MOUSE
θ value	3.0926 (rank : 395)	NC score	0.055343 (rank : 584)
Query Neighborhood Hits	554	Target Neighborhood Hits	181	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

BLNK_MOUSE
θ value	3.0926 (rank : 396)	NC score	0.088347 (rank : 332)
Query Neighborhood Hits	554	Target Neighborhood Hits	296	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CO4A4_HUMAN
θ value	3.0926 (rank : 397)	NC score	0.028357 (rank : 731)
Query Neighborhood Hits	554	Target Neighborhood Hits	440	Shared Neighborhood Hits	78
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

CPSF7_HUMAN
θ value	3.0926 (rank : 398)	NC score	0.055282 (rank : 586)
Query Neighborhood Hits	554	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N684, Q7Z3H9, Q9H025, Q9H9V1	Gene names	CPSF7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Pre-mRNA cleavage factor Im 59 kDa subunit).

CPSF7_MOUSE
θ value	3.0926 (rank : 399)	NC score	0.055338 (rank : 585)
Query Neighborhood Hits	554	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BTV2, Q3TNF1, Q8BKE7, Q8CFS8	Gene names	Cpsf7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7.

FGR_MOUSE
θ value	3.0926 (rank : 400)	NC score	0.094256 (rank : 310)
Query Neighborhood Hits	554	Target Neighborhood Hits	1069	Shared Neighborhood Hits	171
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FIGN_MOUSE
θ value	3.0926 (rank : 401)	NC score	0.012629 (rank : 778)
Query Neighborhood Hits	554	Target Neighborhood Hits	165	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

FMNL_HUMAN
θ value	3.0926 (rank : 402)	NC score	0.093970 (rank : 312)
Query Neighborhood Hits	554	Target Neighborhood Hits	529	Shared Neighborhood Hits	106
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GGN_MOUSE
θ value	3.0926 (rank : 403)	NC score	0.090360 (rank : 321)
Query Neighborhood Hits	554	Target Neighborhood Hits	311	Shared Neighborhood Hits	73
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

HTF4_HUMAN
θ value	3.0926 (rank : 404)	NC score	0.031797 (rank : 712)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

INP4B_HUMAN
θ value	3.0926 (rank : 405)	NC score	0.011437 (rank : 783)
Query Neighborhood Hits	554	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	O15327, Q6IN59, Q6PJB4	Gene names	INPP4B
Domain Architecture	No domain graphic available
Description	Type II inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II).

K0460_HUMAN
θ value	3.0926 (rank : 406)	NC score	0.042920 (rank : 672)
Query Neighborhood Hits	554	Target Neighborhood Hits	357	Shared Neighborhood Hits	51
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

K0460_MOUSE
θ value	3.0926 (rank : 407)	NC score	0.050449 (rank : 647)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	61
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

NALP1_HUMAN
θ value	3.0926 (rank : 408)	NC score	0.007615 (rank : 794)
Query Neighborhood Hits	554	Target Neighborhood Hits	138	Shared Neighborhood Hits	18
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NFRKB_HUMAN
θ value	3.0926 (rank : 409)	NC score	0.056186 (rank : 574)
Query Neighborhood Hits	554	Target Neighborhood Hits	211	Shared Neighborhood Hits	50
SwissProt Accessions	Q6P4R8, Q12869, Q15312, Q9H048	Gene names	NFRKB
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

NR4A3_MOUSE
θ value	3.0926 (rank : 410)	NC score	0.004864 (rank : 802)
Query Neighborhood Hits	554	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

OST4_HUMAN
θ value	3.0926 (rank : 411)	NC score	0.013918 (rank : 772)
Query Neighborhood Hits	554	Target Neighborhood Hits	95	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y661, Q5QI42, Q8NDC2	Gene names	HS3ST4, 3OST4
Domain Architecture	No domain graphic available
Description	Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4).

PLCG1_HUMAN
θ value	3.0926 (rank : 412)	NC score	0.196722 (rank : 119)
Query Neighborhood Hits	554	Target Neighborhood Hits	293	Shared Neighborhood Hits	144
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	3.0926 (rank : 413)	NC score	0.204830 (rank : 114)
Query Neighborhood Hits	554	Target Neighborhood Hits	314	Shared Neighborhood Hits	149
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PTK6_MOUSE
θ value	3.0926 (rank : 414)	NC score	0.072634 (rank : 415)
Query Neighborhood Hits	554	Target Neighborhood Hits	1026	Shared Neighborhood Hits	152
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

R3HD2_MOUSE
θ value	3.0926 (rank : 415)	NC score	0.130118 (rank : 217)
Query Neighborhood Hits	554	Target Neighborhood Hits	397	Shared Neighborhood Hits	135
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RBM12_MOUSE
θ value	3.0926 (rank : 416)	NC score	0.056898 (rank : 562)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

RCOR3_HUMAN
θ value	3.0926 (rank : 417)	NC score	0.048330 (rank : 656)
Query Neighborhood Hits	554	Target Neighborhood Hits	161	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P2K3, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83	Gene names	RCOR3, KIAA1343
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

S3TC1_HUMAN
θ value	3.0926 (rank : 418)	NC score	0.049159 (rank : 653)
Query Neighborhood Hits	554	Target Neighborhood Hits	78	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

SF04_HUMAN
θ value	3.0926 (rank : 419)	NC score	0.035711 (rank : 692)
Query Neighborhood Hits	554	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWZ8, O60378, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3	Gene names	SF4
Domain Architecture	No domain graphic available
Description	Splicing factor 4 (RNA-binding protein RBP).

SF3A1_MOUSE
θ value	3.0926 (rank : 420)	NC score	0.071018 (rank : 430)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

SHLB1_MOUSE
θ value	3.0926 (rank : 421)	NC score	0.157913 (rank : 164)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SIN3A_HUMAN
θ value	3.0926 (rank : 422)	NC score	0.042041 (rank : 676)
Query Neighborhood Hits	554	Target Neighborhood Hits	180	Shared Neighborhood Hits	51
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

TARSH_HUMAN
θ value	3.0926 (rank : 423)	NC score	0.152257 (rank : 172)
Query Neighborhood Hits	554	Target Neighborhood Hits	768	Shared Neighborhood Hits	201
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TRIP6_HUMAN
θ value	3.0926 (rank : 424)	NC score	0.032020 (rank : 708)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	36
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

UBP2L_MOUSE
θ value	3.0926 (rank : 425)	NC score	0.031939 (rank : 709)
Query Neighborhood Hits	554	Target Neighborhood Hits	173	Shared Neighborhood Hits	31
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

VASP_HUMAN
θ value	3.0926 (rank : 426)	NC score	0.061329 (rank : 517)
Query Neighborhood Hits	554	Target Neighborhood Hits	201	Shared Neighborhood Hits	56
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

WASF4_HUMAN
θ value	3.0926 (rank : 427)	NC score	0.107548 (rank : 267)
Query Neighborhood Hits	554	Target Neighborhood Hits	282	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

X3CL1_HUMAN
θ value	3.0926 (rank : 428)	NC score	0.041445 (rank : 680)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	27
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

ZIM10_HUMAN
θ value	3.0926 (rank : 429)	NC score	0.112226 (rank : 253)
Query Neighborhood Hits	554	Target Neighborhood Hits	577	Shared Neighborhood Hits	181
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZN598_HUMAN
θ value	3.0926 (rank : 430)	NC score	0.047572 (rank : 659)
Query Neighborhood Hits	554	Target Neighborhood Hits	339	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

BSN_HUMAN
θ value	4.03905 (rank : 431)	NC score	0.110724 (rank : 257)
Query Neighborhood Hits	554	Target Neighborhood Hits	1537	Shared Neighborhood Hits	208
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BTBD7_MOUSE
θ value	4.03905 (rank : 432)	NC score	0.023368 (rank : 748)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

CIC_HUMAN
θ value	4.03905 (rank : 433)	NC score	0.115759 (rank : 243)
Query Neighborhood Hits	554	Target Neighborhood Hits	992	Shared Neighborhood Hits	219
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO039_HUMAN
θ value	4.03905 (rank : 434)	NC score	0.061149 (rank : 519)
Query Neighborhood Hits	554	Target Neighborhood Hits	264	Shared Neighborhood Hits	76
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CRK_HUMAN
θ value	4.03905 (rank : 435)	NC score	0.294253 (rank : 78)
Query Neighborhood Hits	554	Target Neighborhood Hits	308	Shared Neighborhood Hits	172
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CS007_MOUSE
θ value	4.03905 (rank : 436)	NC score	0.055240 (rank : 589)
Query Neighborhood Hits	554	Target Neighborhood Hits	464	Shared Neighborhood Hits	89
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DDX27_HUMAN
θ value	4.03905 (rank : 437)	NC score	0.001975 (rank : 810)
Query Neighborhood Hits	554	Target Neighborhood Hits	197	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_MOUSE
θ value	4.03905 (rank : 438)	NC score	0.002120 (rank : 809)
Query Neighborhood Hits	554	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DYR1B_HUMAN
θ value	4.03905 (rank : 439)	NC score	0.015219 (rank : 769)
Query Neighborhood Hits	554	Target Neighborhood Hits	831	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

ENAH_HUMAN
θ value	4.03905 (rank : 440)	NC score	0.059238 (rank : 535)
Query Neighborhood Hits	554	Target Neighborhood Hits	784	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ETV5_MOUSE
θ value	4.03905 (rank : 441)	NC score	0.047019 (rank : 662)
Query Neighborhood Hits	554	Target Neighborhood Hits	328	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

FNBP2_HUMAN
θ value	4.03905 (rank : 442)	NC score	0.154162 (rank : 168)
Query Neighborhood Hits	554	Target Neighborhood Hits	432	Shared Neighborhood Hits	161
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FYV1_HUMAN
θ value	4.03905 (rank : 443)	NC score	0.015750 (rank : 768)
Query Neighborhood Hits	554	Target Neighborhood Hits	217	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

HDGF_MOUSE
θ value	4.03905 (rank : 444)	NC score	0.018174 (rank : 763)
Query Neighborhood Hits	554	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	P51859, Q8BPG7, Q9CYA4, Q9JK87	Gene names	Hdgf, Tdrm1
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF).

KCNC3_HUMAN
θ value	4.03905 (rank : 445)	NC score	0.010788 (rank : 784)
Query Neighborhood Hits	554	Target Neighborhood Hits	256	Shared Neighborhood Hits	47
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

LITAF_HUMAN
θ value	4.03905 (rank : 446)	NC score	0.021458 (rank : 752)
Query Neighborhood Hits	554	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q99732, Q9C0L6	Gene names	LITAF, PIG7, SIMPLE
Domain Architecture	No domain graphic available
Description	Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS- induced TNF-alpha factor) (p53-induced protein 7) (Small integral membrane protein of lysosome/late endosome).

MISS_MOUSE
θ value	4.03905 (rank : 447)	NC score	0.169590 (rank : 152)
Query Neighborhood Hits	554	Target Neighborhood Hits	444	Shared Neighborhood Hits	175
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

NBR1_MOUSE
θ value	4.03905 (rank : 448)	NC score	0.018174 (rank : 762)
Query Neighborhood Hits	554	Target Neighborhood Hits	116	Shared Neighborhood Hits	15
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

PAX9_MOUSE
θ value	4.03905 (rank : 449)	NC score	0.014405 (rank : 770)
Query Neighborhood Hits	554	Target Neighborhood Hits	67	Shared Neighborhood Hits	15
SwissProt Accessions	P47242	Gene names	Pax9, Pax-9
Domain Architecture
Description	Paired box protein Pax-9.

PDCD7_HUMAN
θ value	4.03905 (rank : 450)	NC score	0.045769 (rank : 666)
Query Neighborhood Hits	554	Target Neighborhood Hits	255	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

PER1_MOUSE
θ value	4.03905 (rank : 451)	NC score	0.037542 (rank : 687)
Query Neighborhood Hits	554	Target Neighborhood Hits	235	Shared Neighborhood Hits	59
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PKD2_MOUSE
θ value	4.03905 (rank : 452)	NC score	0.007351 (rank : 796)
Query Neighborhood Hits	554	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

SF3A1_HUMAN
θ value	4.03905 (rank : 453)	NC score	0.063985 (rank : 494)
Query Neighborhood Hits	554	Target Neighborhood Hits	199	Shared Neighborhood Hits	55
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SHLB1_HUMAN
θ value	4.03905 (rank : 454)	NC score	0.152548 (rank : 171)
Query Neighborhood Hits	554	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SOX7_HUMAN
θ value	4.03905 (rank : 455)	NC score	0.016614 (rank : 767)
Query Neighborhood Hits	554	Target Neighborhood Hits	140	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BT81	Gene names	SOX7
Domain Architecture
Description	Transcription factor SOX-7.

SP7_HUMAN
θ value	4.03905 (rank : 456)	NC score	-0.003197 (rank : 818)
Query Neighborhood Hits	554	Target Neighborhood Hits	734	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDD2	Gene names	SP7, OSX
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix).

SPN90_HUMAN
θ value	4.03905 (rank : 457)	NC score	0.137300 (rank : 200)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SRRM1_HUMAN
θ value	4.03905 (rank : 458)	NC score	0.088760 (rank : 329)
Query Neighborhood Hits	554	Target Neighborhood Hits	690	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

WIRE_MOUSE
θ value	4.03905 (rank : 459)	NC score	0.112693 (rank : 250)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	88
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

WNK2_HUMAN
θ value	4.03905 (rank : 460)	NC score	0.049307 (rank : 652)
Query Neighborhood Hits	554	Target Neighborhood Hits	1407	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZN653_MOUSE
θ value	4.03905 (rank : 461)	NC score	-0.007611 (rank : 819)
Query Neighborhood Hits	554	Target Neighborhood Hits	744	Shared Neighborhood Hits	14
SwissProt Accessions	Q6YND2, Q8BHT8, Q8CI02	Gene names	Znf653, Zfp653, Zip67
Domain Architecture	No domain graphic available
Description	Zinc finger protein 653 (67 kDa zinc finger protein) (Zinc finger protein Zip67).

ATBF1_HUMAN
θ value	5.27518 (rank : 462)	NC score	0.016647 (rank : 766)
Query Neighborhood Hits	554	Target Neighborhood Hits	1547	Shared Neighborhood Hits	95
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CCDC9_HUMAN
θ value	5.27518 (rank : 463)	NC score	0.023335 (rank : 749)
Query Neighborhood Hits	554	Target Neighborhood Hits	175	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

CENG1_HUMAN
θ value	5.27518 (rank : 464)	NC score	0.023554 (rank : 746)
Query Neighborhood Hits	554	Target Neighborhood Hits	544	Shared Neighborhood Hits	36
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	5.27518 (rank : 465)	NC score	0.026719 (rank : 739)
Query Neighborhood Hits	554	Target Neighborhood Hits	531	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CO3A1_MOUSE
θ value	5.27518 (rank : 466)	NC score	0.027320 (rank : 734)
Query Neighborhood Hits	554	Target Neighborhood Hits	466	Shared Neighborhood Hits	59
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CT075_HUMAN
θ value	5.27518 (rank : 467)	NC score	0.008007 (rank : 793)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

DVL1L_HUMAN
θ value	5.27518 (rank : 468)	NC score	0.008029 (rank : 792)
Query Neighborhood Hits	554	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

KI13B_HUMAN
θ value	5.27518 (rank : 469)	NC score	0.008686 (rank : 791)
Query Neighborhood Hits	554	Target Neighborhood Hits	492	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

LR37A_HUMAN
θ value	5.27518 (rank : 470)	NC score	0.075541 (rank : 393)
Query Neighborhood Hits	554	Target Neighborhood Hits	720	Shared Neighborhood Hits	135
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

NFAT5_MOUSE
θ value	5.27518 (rank : 471)	NC score	0.019770 (rank : 757)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

NR4A1_MOUSE
θ value	5.27518 (rank : 472)	NC score	0.001176 (rank : 813)
Query Neighborhood Hits	554	Target Neighborhood Hits	128	Shared Neighborhood Hits	6
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

PLCG2_HUMAN
θ value	5.27518 (rank : 473)	NC score	0.195310 (rank : 121)
Query Neighborhood Hits	554	Target Neighborhood Hits	280	Shared Neighborhood Hits	145
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SAM68_MOUSE
θ value	5.27518 (rank : 474)	NC score	0.031442 (rank : 715)
Query Neighborhood Hits	554	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q60749, Q3U8T3, Q60735, Q99M33	Gene names	Khdrbs1
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

SOX17_MOUSE
θ value	5.27518 (rank : 475)	NC score	0.031170 (rank : 718)
Query Neighborhood Hits	554	Target Neighborhood Hits	223	Shared Neighborhood Hits	60
SwissProt Accessions	Q61473, Q61472, Q62248	Gene names	Sox17, Sox-17
Domain Architecture
Description	Transcription factor SOX-17.

SSH2_MOUSE
θ value	5.27518 (rank : 476)	NC score	0.004493 (rank : 804)
Query Neighborhood Hits	554	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

ZEP2_MOUSE
θ value	5.27518 (rank : 477)	NC score	0.006708 (rank : 797)
Query Neighborhood Hits	554	Target Neighborhood Hits	964	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

AAK1_MOUSE
θ value	6.88961 (rank : 478)	NC score	0.031352 (rank : 716)
Query Neighborhood Hits	554	Target Neighborhood Hits	1051	Shared Neighborhood Hits	132
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ACRO_HUMAN
θ value	6.88961 (rank : 479)	NC score	0.004203 (rank : 805)
Query Neighborhood Hits	554	Target Neighborhood Hits	291	Shared Neighborhood Hits	51
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

BCL9_HUMAN
θ value	6.88961 (rank : 480)	NC score	0.174308 (rank : 145)
Query Neighborhood Hits	554	Target Neighborhood Hits	1008	Shared Neighborhood Hits	267
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CCNK_HUMAN
θ value	6.88961 (rank : 481)	NC score	0.032439 (rank : 706)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	27
SwissProt Accessions	O75909, Q96B63, Q9NNY9	Gene names	CCNK, CPR4
Domain Architecture
Description	Cyclin-K.

CTTB2_HUMAN
θ value	6.88961 (rank : 482)	NC score	0.029713 (rank : 724)
Query Neighborhood Hits	554	Target Neighborhood Hits	1061	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

DSCAM_HUMAN
θ value	6.88961 (rank : 483)	NC score	0.001622 (rank : 811)
Query Neighborhood Hits	554	Target Neighborhood Hits	524	Shared Neighborhood Hits	11
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

ECM1_HUMAN
θ value	6.88961 (rank : 484)	NC score	0.058818 (rank : 540)
Query Neighborhood Hits	554	Target Neighborhood Hits	182	Shared Neighborhood Hits	73
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

EP15_MOUSE
θ value	6.88961 (rank : 485)	NC score	0.037244 (rank : 688)
Query Neighborhood Hits	554	Target Neighborhood Hits	820	Shared Neighborhood Hits	38
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FIGN_HUMAN
θ value	6.88961 (rank : 486)	NC score	0.013467 (rank : 775)
Query Neighborhood Hits	554	Target Neighborhood Hits	176	Shared Neighborhood Hits	30
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

FOXN4_HUMAN
θ value	6.88961 (rank : 487)	NC score	0.027174 (rank : 735)
Query Neighborhood Hits	554	Target Neighborhood Hits	248	Shared Neighborhood Hits	75
SwissProt Accessions	Q96NZ1, Q6ZMR4, Q96NZ0	Gene names	FOXN4
Domain Architecture	No domain graphic available
Description	Forkhead box protein N4.

GAB1_MOUSE
θ value	6.88961 (rank : 488)	NC score	0.066903 (rank : 468)
Query Neighborhood Hits	554	Target Neighborhood Hits	233	Shared Neighborhood Hits	74
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

HNRL1_MOUSE
θ value	6.88961 (rank : 489)	NC score	0.029727 (rank : 723)
Query Neighborhood Hits	554	Target Neighborhood Hits	200	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

IPF1_HUMAN
θ value	6.88961 (rank : 490)	NC score	-0.001341 (rank : 817)
Query Neighborhood Hits	554	Target Neighborhood Hits	330	Shared Neighborhood Hits	12
SwissProt Accessions	P52945, O60594	Gene names	IPF1, PDX1
Domain Architecture
Description	Insulin promoter factor 1 (IPF-1) (Pancreas/duodenum homeobox 1) (PDX- 1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) (Insulin upstream factor 1) (IUF-1) (Glucose- sensitive factor) (GSF).

ITK_HUMAN
θ value	6.88961 (rank : 491)	NC score	0.061426 (rank : 516)
Query Neighborhood Hits	554	Target Neighborhood Hits	1016	Shared Neighborhood Hits	138
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

K1024_MOUSE
θ value	6.88961 (rank : 492)	NC score	0.009757 (rank : 790)
Query Neighborhood Hits	554	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3V7, Q69ZS9	Gene names	Kiaa1024
Domain Architecture
Description	UPF0258 protein KIAA1024 (Protein DD1).

LOXL1_HUMAN
θ value	6.88961 (rank : 493)	NC score	0.020978 (rank : 753)
Query Neighborhood Hits	554	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

LPP_HUMAN
θ value	6.88961 (rank : 494)	NC score	0.138223 (rank : 197)
Query Neighborhood Hits	554	Target Neighborhood Hits	775	Shared Neighborhood Hits	240
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MAML1_MOUSE
θ value	6.88961 (rank : 495)	NC score	0.054093 (rank : 606)
Query Neighborhood Hits	554	Target Neighborhood Hits	279	Shared Neighborhood Hits	75
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MYRIP_HUMAN
θ value	6.88961 (rank : 496)	NC score	0.013537 (rank : 774)
Query Neighborhood Hits	554	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NOTC1_HUMAN
θ value	6.88961 (rank : 497)	NC score	0.004559 (rank : 803)
Query Neighborhood Hits	554	Target Neighborhood Hits	906	Shared Neighborhood Hits	36
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PARP9_HUMAN
θ value	6.88961 (rank : 498)	NC score	0.006371 (rank : 798)
Query Neighborhood Hits	554	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IXQ6, Q8TCP3, Q9BZL8, Q9BZL9	Gene names	PARP9, BAL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 9 (EC 2.4.2.30) (PARP-9) (B aggressive lymphoma protein).

PAX9_HUMAN
θ value	6.88961 (rank : 499)	NC score	0.012907 (rank : 776)
Query Neighborhood Hits	554	Target Neighborhood Hits	92	Shared Neighborhood Hits	22
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

PCQAP_MOUSE
θ value	6.88961 (rank : 500)	NC score	0.072244 (rank : 422)
Query Neighborhood Hits	554	Target Neighborhood Hits	506	Shared Neighborhood Hits	86
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PEX19_HUMAN
θ value	6.88961 (rank : 501)	NC score	0.013731 (rank : 773)
Query Neighborhood Hits	554	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P40855, Q8NI97	Gene names	PEX19, HK33, PXF
Domain Architecture
Description	Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) (33 kDa housekeeping protein).

RC3H1_HUMAN
θ value	6.88961 (rank : 502)	NC score	0.053226 (rank : 618)
Query Neighborhood Hits	554	Target Neighborhood Hits	433	Shared Neighborhood Hits	114
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RN165_HUMAN
θ value	6.88961 (rank : 503)	NC score	0.007579 (rank : 795)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

RX_HUMAN
θ value	6.88961 (rank : 504)	NC score	0.003746 (rank : 806)
Query Neighborhood Hits	554	Target Neighborhood Hits	423	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y2V3	Gene names	RAX, RX
Domain Architecture
Description	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein).

SMOO_HUMAN
θ value	6.88961 (rank : 505)	NC score	0.043361 (rank : 671)
Query Neighborhood Hits	554	Target Neighborhood Hits	391	Shared Neighborhood Hits	67
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SPEG_HUMAN
θ value	6.88961 (rank : 506)	NC score	0.034126 (rank : 700)
Query Neighborhood Hits	554	Target Neighborhood Hits	1762	Shared Neighborhood Hits	188
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPN90_MOUSE
θ value	6.88961 (rank : 507)	NC score	0.118029 (rank : 241)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRGP1_HUMAN
θ value	6.88961 (rank : 508)	NC score	0.156295 (rank : 165)
Query Neighborhood Hits	554	Target Neighborhood Hits	390	Shared Neighborhood Hits	143
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TAU_HUMAN
θ value	6.88961 (rank : 509)	NC score	0.053536 (rank : 614)
Query Neighborhood Hits	554	Target Neighborhood Hits	448	Shared Neighborhood Hits	97
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TOPRS_MOUSE
θ value	6.88961 (rank : 510)	NC score	0.006272 (rank : 799)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	7
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TRI66_MOUSE
θ value	6.88961 (rank : 511)	NC score	0.059731 (rank : 530)
Query Neighborhood Hits	554	Target Neighborhood Hits	491	Shared Neighborhood Hits	97
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

WBP11_HUMAN
θ value	6.88961 (rank : 512)	NC score	0.099191 (rank : 293)
Query Neighborhood Hits	554	Target Neighborhood Hits	354	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

ZO1_HUMAN
θ value	6.88961 (rank : 513)	NC score	0.039832 (rank : 683)
Query Neighborhood Hits	554	Target Neighborhood Hits	474	Shared Neighborhood Hits	94
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	6.88961 (rank : 514)	NC score	0.031914 (rank : 710)
Query Neighborhood Hits	554	Target Neighborhood Hits	453	Shared Neighborhood Hits	73
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZYX_MOUSE
θ value	6.88961 (rank : 515)	NC score	0.058127 (rank : 550)
Query Neighborhood Hits	554	Target Neighborhood Hits	347	Shared Neighborhood Hits	67
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

AB1IP_HUMAN
θ value	8.99809 (rank : 516)	NC score	0.061002 (rank : 521)
Query Neighborhood Hits	554	Target Neighborhood Hits	213	Shared Neighborhood Hits	59
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

ABL1_HUMAN
θ value	8.99809 (rank : 517)	NC score	0.065997 (rank : 474)
Query Neighborhood Hits	554	Target Neighborhood Hits	1220	Shared Neighborhood Hits	156
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	8.99809 (rank : 518)	NC score	0.066665 (rank : 470)
Query Neighborhood Hits	554	Target Neighborhood Hits	1178	Shared Neighborhood Hits	161
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ANTR1_HUMAN
θ value	8.99809 (rank : 519)	NC score	0.045374 (rank : 667)
Query Neighborhood Hits	554	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H6X2, Q96P02, Q9NVP3	Gene names	ANTXR1, ATR, TEM8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

APXL_HUMAN
θ value	8.99809 (rank : 520)	NC score	0.047473 (rank : 660)
Query Neighborhood Hits	554	Target Neighborhood Hits	553	Shared Neighborhood Hits	77
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ATRIP_MOUSE
θ value	8.99809 (rank : 521)	NC score	0.009976 (rank : 786)
Query Neighborhood Hits	554	Target Neighborhood Hits	248	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BMG1	Gene names	Atrip
Domain Architecture	No domain graphic available
Description	ATR-interacting protein (ATM and Rad3-related-interacting protein).

CAC1A_MOUSE
θ value	8.99809 (rank : 522)	NC score	0.009758 (rank : 789)
Query Neighborhood Hits	554	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CIC_MOUSE
θ value	8.99809 (rank : 523)	NC score	0.076241 (rank : 387)
Query Neighborhood Hits	554	Target Neighborhood Hits	742	Shared Neighborhood Hits	162
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DBNL_HUMAN
θ value	8.99809 (rank : 524)	NC score	0.263689 (rank : 89)
Query Neighborhood Hits	554	Target Neighborhood Hits	244	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	8.99809 (rank : 525)	NC score	0.264347 (rank : 87)
Query Neighborhood Hits	554	Target Neighborhood Hits	306	Shared Neighborhood Hits	152
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DOK1_MOUSE
θ value	8.99809 (rank : 526)	NC score	0.050053 (rank : 651)
Query Neighborhood Hits	554	Target Neighborhood Hits	82	Shared Neighborhood Hits	30
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

DREB_HUMAN
θ value	8.99809 (rank : 527)	NC score	0.031132 (rank : 719)
Query Neighborhood Hits	554	Target Neighborhood Hits	450	Shared Neighborhood Hits	43
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

EP400_HUMAN
θ value	8.99809 (rank : 528)	NC score	0.047439 (rank : 661)
Query Neighborhood Hits	554	Target Neighborhood Hits	556	Shared Neighborhood Hits	106
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

FOXN1_HUMAN
θ value	8.99809 (rank : 529)	NC score	0.038369 (rank : 686)
Query Neighborhood Hits	554	Target Neighborhood Hits	377	Shared Neighborhood Hits	109
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

GAK3_HUMAN
θ value	8.99809 (rank : 530)	NC score	0.096167 (rank : 308)
Query Neighborhood Hits	554	Target Neighborhood Hits	182	Shared Neighborhood Hits	73
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GP153_MOUSE
θ value	8.99809 (rank : 531)	NC score	0.003702 (rank : 807)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K0Z9, Q80T37, Q8CFK0	Gene names	Gpr153, Pgr1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

GR65_HUMAN
θ value	8.99809 (rank : 532)	NC score	0.028849 (rank : 727)
Query Neighborhood Hits	554	Target Neighborhood Hits	148	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

HCN4_HUMAN
θ value	8.99809 (rank : 533)	NC score	0.018233 (rank : 761)
Query Neighborhood Hits	554	Target Neighborhood Hits	303	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

IL2RB_MOUSE
θ value	8.99809 (rank : 534)	NC score	0.019585 (rank : 758)
Query Neighborhood Hits	554	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	P16297, Q3TZT2	Gene names	Il2rb
Domain Architecture
Description	Interleukin-2 receptor beta chain precursor (IL-2 receptor) (P70-75) (High affinity IL-2 receptor subunit beta) (CD122 antigen).

K0355_HUMAN
θ value	8.99809 (rank : 535)	NC score	0.026156 (rank : 741)
Query Neighborhood Hits	554	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	O15063	Gene names	KIAA0355
Domain Architecture	No domain graphic available
Description	Protein KIAA0355.

KCNN3_MOUSE
θ value	8.99809 (rank : 536)	NC score	0.012147 (rank : 780)
Query Neighborhood Hits	554	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

LAMA4_MOUSE
θ value	8.99809 (rank : 537)	NC score	0.000994 (rank : 815)
Query Neighborhood Hits	554	Target Neighborhood Hits	584	Shared Neighborhood Hits	11
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

PDC6I_HUMAN
θ value	8.99809 (rank : 538)	NC score	0.074074 (rank : 402)
Query Neighborhood Hits	554	Target Neighborhood Hits	278	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

PDZD2_HUMAN
θ value	8.99809 (rank : 539)	NC score	0.054788 (rank : 596)
Query Neighborhood Hits	554	Target Neighborhood Hits	772	Shared Neighborhood Hits	128
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PHC2_MOUSE
θ value	8.99809 (rank : 540)	NC score	0.041633 (rank : 678)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

PRG4_HUMAN
θ value	8.99809 (rank : 541)	NC score	0.070815 (rank : 433)
Query Neighborhood Hits	554	Target Neighborhood Hits	764	Shared Neighborhood Hits	113
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRR8_HUMAN
θ value	8.99809 (rank : 542)	NC score	0.062936 (rank : 502)
Query Neighborhood Hits	554	Target Neighborhood Hits	217	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

PTPR2_HUMAN
θ value	8.99809 (rank : 543)	NC score	0.006198 (rank : 800)
Query Neighborhood Hits	554	Target Neighborhood Hits	103	Shared Neighborhood Hits	6
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

RBP2_HUMAN
θ value	8.99809 (rank : 544)	NC score	0.009912 (rank : 787)
Query Neighborhood Hits	554	Target Neighborhood Hits	249	Shared Neighborhood Hits	33
SwissProt Accessions	P49792, Q13074, Q15280, Q53TE2, Q59FH7	Gene names	RANBP2, NUP358
Domain Architecture
Description	Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270).

SC24B_HUMAN
θ value	8.99809 (rank : 545)	NC score	0.029153 (rank : 726)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	30
SwissProt Accessions	O95487	Gene names	SEC24B
Domain Architecture
Description	Protein transport protein Sec24B (SEC24-related protein B).

SELV_HUMAN
θ value	8.99809 (rank : 546)	NC score	0.057634 (rank : 554)
Query Neighborhood Hits	554	Target Neighborhood Hits	118	Shared Neighborhood Hits	37
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

SI1L2_MOUSE
θ value	8.99809 (rank : 547)	NC score	0.005185 (rank : 801)
Query Neighborhood Hits	554	Target Neighborhood Hits	124	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

ST18_HUMAN
θ value	8.99809 (rank : 548)	NC score	0.002286 (rank : 808)
Query Neighborhood Hits	554	Target Neighborhood Hits	252	Shared Neighborhood Hits	6
SwissProt Accessions	O60284	Gene names	ST18, KIAA0535, ZNF387
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18 (Zinc finger protein 387).

TEAD2_HUMAN
θ value	8.99809 (rank : 549)	NC score	0.010061 (rank : 785)
Query Neighborhood Hits	554	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q15562, Q96IG3	Gene names	TEAD2, TEF4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2).

TXK_HUMAN
θ value	8.99809 (rank : 550)	NC score	0.062518 (rank : 506)
Query Neighborhood Hits	554	Target Neighborhood Hits	971	Shared Neighborhood Hits	131
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	8.99809 (rank : 551)	NC score	0.067640 (rank : 463)
Query Neighborhood Hits	554	Target Neighborhood Hits	980	Shared Neighborhood Hits	140
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WWP1_MOUSE
θ value	8.99809 (rank : 552)	NC score	0.001107 (rank : 814)
Query Neighborhood Hits	554	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

YAP1_HUMAN
θ value	8.99809 (rank : 553)	NC score	0.026217 (rank : 740)
Query Neighborhood Hits	554	Target Neighborhood Hits	173	Shared Neighborhood Hits	46
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ZDHC8_HUMAN
θ value	8.99809 (rank : 554)	NC score	0.022392 (rank : 751)
Query Neighborhood Hits	554	Target Neighborhood Hits	234	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

3BP1_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.059300 (rank : 534)
Query Neighborhood Hits	554	Target Neighborhood Hits	376	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

3BP2_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.053211 (rank : 619)
Query Neighborhood Hits	554	Target Neighborhood Hits	296	Shared Neighborhood Hits	103
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.260071 (rank : 95)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	162
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.262917 (rank : 90)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	158
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL2_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.059480 (rank : 533)
Query Neighborhood Hits	554	Target Neighborhood Hits	1045	Shared Neighborhood Hits	129
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ALEX_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.088314 (rank : 334)
Query Neighborhood Hits	554	Target Neighborhood Hits	361	Shared Neighborhood Hits	106
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ALEX_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.052490 (rank : 626)
Query Neighborhood Hits	554	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

AMPH_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.109399 (rank : 264)
Query Neighborhood Hits	554	Target Neighborhood Hits	455	Shared Neighborhood Hits	132
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.093913 (rank : 313)
Query Neighborhood Hits	554	Target Neighborhood Hits	291	Shared Neighborhood Hits	92
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANK2_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.064144 (rank : 493)
Query Neighborhood Hits	554	Target Neighborhood Hits	1615	Shared Neighborhood Hits	210
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

APS_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.056676 (rank : 565)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.058723 (rank : 541)
Query Neighborhood Hits	554	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.058842 (rank : 539)
Query Neighborhood Hits	554	Target Neighborhood Hits	266	Shared Neighborhood Hits	65
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG3_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.079137 (rank : 372)
Query Neighborhood Hits	554	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.078771 (rank : 374)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.179991 (rank : 139)
Query Neighborhood Hits	554	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.101412 (rank : 282)
Query Neighborhood Hits	554	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.072483 (rank : 418)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.075853 (rank : 389)
Query Neighborhood Hits	554	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.065265 (rank : 481)
Query Neighborhood Hits	554	Target Neighborhood Hits	187	Shared Neighborhood Hits	29
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.070961 (rank : 431)
Query Neighborhood Hits	554	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.062448 (rank : 507)
Query Neighborhood Hits	554	Target Neighborhood Hits	375	Shared Neighborhood Hits	46
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.062419 (rank : 508)
Query Neighborhood Hits	554	Target Neighborhood Hits	351	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.061479 (rank : 515)
Query Neighborhood Hits	554	Target Neighborhood Hits	344	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.068652 (rank : 455)
Query Neighborhood Hits	554	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.073218 (rank : 408)
Query Neighborhood Hits	554	Target Neighborhood Hits	129	Shared Neighborhood Hits	42
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.084714 (rank : 348)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	53
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ATX1_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.055789 (rank : 580)
Query Neighborhood Hits	554	Target Neighborhood Hits	264	Shared Neighborhood Hits	85
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

ATX2_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.062150 (rank : 512)
Query Neighborhood Hits	554	Target Neighborhood Hits	375	Shared Neighborhood Hits	82
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

ATX2_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.085254 (rank : 345)
Query Neighborhood Hits	554	Target Neighborhood Hits	445	Shared Neighborhood Hits	127
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

ATX7_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.064611 (rank : 487)
Query Neighborhood Hits	554	Target Neighborhood Hits	351	Shared Neighborhood Hits	115
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

ATX7_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.061279 (rank : 518)
Query Neighborhood Hits	554	Target Neighborhood Hits	328	Shared Neighborhood Hits	116
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

AUTS2_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.064250 (rank : 491)
Query Neighborhood Hits	554	Target Neighborhood Hits	342	Shared Neighborhood Hits	86
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

BAG3_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.098012 (rank : 298)
Query Neighborhood Hits	554	Target Neighborhood Hits	513	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BAIP2_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.052774 (rank : 622)
Query Neighborhood Hits	554	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.053650 (rank : 613)
Query Neighborhood Hits	554	Target Neighborhood Hits	185	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAT3_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.067863 (rank : 460)
Query Neighborhood Hits	554	Target Neighborhood Hits	490	Shared Neighborhood Hits	123
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAT3_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.067217 (rank : 467)
Query Neighborhood Hits	554	Target Neighborhood Hits	518	Shared Neighborhood Hits	129
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

BAZ2A_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.055375 (rank : 583)
Query Neighborhood Hits	554	Target Neighborhood Hits	780	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BAZ2A_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.072736 (rank : 412)
Query Neighborhood Hits	554	Target Neighborhood Hits	744	Shared Neighborhood Hits	158
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BCL9_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.133190 (rank : 210)
Query Neighborhood Hits	554	Target Neighborhood Hits	770	Shared Neighborhood Hits	208
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BCR_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.056567 (rank : 567)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	40
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.069256 (rank : 447)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.058325 (rank : 547)
Query Neighborhood Hits	554	Target Neighborhood Hits	197	Shared Neighborhood Hits	60
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.102644 (rank : 277)
Query Neighborhood Hits	554	Target Neighborhood Hits	335	Shared Neighborhood Hits	123
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.086591 (rank : 337)
Query Neighborhood Hits	554	Target Neighborhood Hits	283	Shared Neighborhood Hits	102
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.070627 (rank : 437)
Query Neighborhood Hits	554	Target Neighborhood Hits	992	Shared Neighborhood Hits	133
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.058592 (rank : 545)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CABIN_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.065046 (rank : 484)
Query Neighborhood Hits	554	Target Neighborhood Hits	490	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CD248_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.069088 (rank : 449)
Query Neighborhood Hits	554	Target Neighborhood Hits	679	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD2_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.124598 (rank : 227)
Query Neighborhood Hits	554	Target Neighborhood Hits	504	Shared Neighborhood Hits	169
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CECR2_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.090763 (rank : 320)
Query Neighborhood Hits	554	Target Neighborhood Hits	543	Shared Neighborhood Hits	146
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CEL_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.132112 (rank : 212)
Query Neighborhood Hits	554	Target Neighborhood Hits	896	Shared Neighborhood Hits	228
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CG1_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.051742 (rank : 640)
Query Neighborhood Hits	554	Target Neighborhood Hits	222	Shared Neighborhood Hits	69
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CIKS_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.062759 (rank : 504)
Query Neighborhood Hits	554	Target Neighborhood Hits	60	Shared Neighborhood Hits	18
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CIP4_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.089135 (rank : 328)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	75
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CIZ1_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.074828 (rank : 397)
Query Neighborhood Hits	554	Target Neighborhood Hits	359	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

CJ078_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.080121 (rank : 370)
Query Neighborhood Hits	554	Target Neighborhood Hits	559	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CJ108_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.066755 (rank : 469)
Query Neighborhood Hits	554	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

CK024_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.057317 (rank : 557)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	64
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

CN155_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.081533 (rank : 362)
Query Neighborhood Hits	554	Target Neighborhood Hits	385	Shared Neighborhood Hits	74
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CO002_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.065490 (rank : 479)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CO039_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.097675 (rank : 301)
Query Neighborhood Hits	554	Target Neighborhood Hits	445	Shared Neighborhood Hits	140
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CRSP2_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.096453 (rank : 306)
Query Neighborhood Hits	554	Target Neighborhood Hits	380	Shared Neighborhood Hits	127
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CRTC1_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.052233 (rank : 629)
Query Neighborhood Hits	554	Target Neighborhood Hits	230	Shared Neighborhood Hits	64
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

CS016_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.081373 (rank : 364)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	78
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

CSF1_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.068782 (rank : 453)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

CSK_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.067732 (rank : 461)
Query Neighborhood Hits	554	Target Neighborhood Hits	1009	Shared Neighborhood Hits	136
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.067651 (rank : 462)
Query Neighborhood Hits	554	Target Neighborhood Hits	1009	Shared Neighborhood Hits	136
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CTDP1_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.052908 (rank : 620)
Query Neighborhood Hits	554	Target Neighborhood Hits	416	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DAB1_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.059911 (rank : 529)
Query Neighborhood Hits	554	Target Neighborhood Hits	219	Shared Neighborhood Hits	85
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

DAPP1_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.060383 (rank : 526)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.060075 (rank : 527)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DIDO1_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.089508 (rank : 324)
Query Neighborhood Hits	554	Target Neighborhood Hits	960	Shared Neighborhood Hits	166
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DMRTD_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.065890 (rank : 475)
Query Neighborhood Hits	554	Target Neighborhood Hits	216	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

DOCK1_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.086494 (rank : 339)
Query Neighborhood Hits	554	Target Neighborhood Hits	191	Shared Neighborhood Hits	106
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOK2_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.066153 (rank : 473)
Query Neighborhood Hits	554	Target Neighborhood Hits	244	Shared Neighborhood Hits	92
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

DOT1L_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.050708 (rank : 646)
Query Neighborhood Hits	554	Target Neighborhood Hits	660	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

ECT2_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.059925 (rank : 528)
Query Neighborhood Hits	554	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.062112 (rank : 514)
Query Neighborhood Hits	554	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.054487 (rank : 597)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	91
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.051897 (rank : 635)
Query Neighborhood Hits	554	Target Neighborhood Hits	221	Shared Neighborhood Hits	86
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EMSY_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.050207 (rank : 650)
Query Neighborhood Hits	554	Target Neighborhood Hits	294	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

ENAM_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.056114 (rank : 576)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

EPN3_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.057190 (rank : 558)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	89
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

ES8L1_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.144634 (rank : 182)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.141672 (rank : 189)
Query Neighborhood Hits	554	Target Neighborhood Hits	143	Shared Neighborhood Hits	90
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L3_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.175529 (rank : 144)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FA47A_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.121318 (rank : 232)
Query Neighborhood Hits	554	Target Neighborhood Hits	451	Shared Neighborhood Hits	138
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FGD1_MOUSE
θ value	θ > 10 (rank : 644)	NC score	0.071842 (rank : 424)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	99
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.055148 (rank : 592)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 646)	NC score	0.052603 (rank : 625)
Query Neighborhood Hits	554	Target Neighborhood Hits	163	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 647)	NC score	0.054364 (rank : 600)
Query Neighborhood Hits	554	Target Neighborhood Hits	249	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.056163 (rank : 575)
Query Neighborhood Hits	554	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.055180 (rank : 591)
Query Neighborhood Hits	554	Target Neighborhood Hits	219	Shared Neighborhood Hits	29
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.055678 (rank : 582)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	34
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FYB_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.073690 (rank : 406)
Query Neighborhood Hits	554	Target Neighborhood Hits	379	Shared Neighborhood Hits	95
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GA2L2_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.084611 (rank : 349)
Query Neighborhood Hits	554	Target Neighborhood Hits	395	Shared Neighborhood Hits	140
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GAB1_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.069612 (rank : 445)
Query Neighborhood Hits	554	Target Neighborhood Hits	279	Shared Neighborhood Hits	97
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAK13_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.067298 (rank : 465)
Query Neighborhood Hits	554	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	P62686	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1p13.3 provirus ancestral Gag polyprotein (Gag polyprotein).

GAK14_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.069482 (rank : 446)
Query Neighborhood Hits	554	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	P62687	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_16p3.3 provirus ancestral Gag polyprotein (Gag polyprotein).

GAK15_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.075029 (rank : 396)
Query Neighborhood Hits	554	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	P62688	Gene names	ERVK4
Domain Architecture	No domain graphic available
Description	HERV-K_3q21.2 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(I) Gag protein).

GAK17_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.075491 (rank : 394)
Query Neighborhood Hits	554	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	P62689	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_11q22.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein].

GAK18_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.086020 (rank : 341)
Query Neighborhood Hits	554	Target Neighborhood Hits	116	Shared Neighborhood Hits	42
SwissProt Accessions	P62690	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.23 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK19_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.072611 (rank : 416)
Query Neighborhood Hits	554	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	P62691	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_4p16.1 provirus ancestral Gag polyprotein (Gag polyprotein).

GAK9_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.075415 (rank : 395)
Query Neighborhood Hits	554	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKH8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q13.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K104 Gag protein) [Contains: Matrix protein].

GGN_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.071777 (rank : 425)
Query Neighborhood Hits	554	Target Neighborhood Hits	269	Shared Neighborhood Hits	78
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GPS2_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.083146 (rank : 354)
Query Neighborhood Hits	554	Target Neighborhood Hits	459	Shared Neighborhood Hits	98
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

GRB10_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.051859 (rank : 638)
Query Neighborhood Hits	554	Target Neighborhood Hits	147	Shared Neighborhood Hits	50
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.054122 (rank : 604)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.063409 (rank : 497)
Query Neighborhood Hits	554	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 666)	NC score	0.064683 (rank : 485)
Query Neighborhood Hits	554	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.053891 (rank : 608)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.058641 (rank : 543)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.062884 (rank : 503)
Query Neighborhood Hits	554	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

IL3B2_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.059505 (rank : 532)
Query Neighborhood Hits	554	Target Neighborhood Hits	372	Shared Neighborhood Hits	128
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

IL3RB_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.050367 (rank : 649)
Query Neighborhood Hits	554	Target Neighborhood Hits	355	Shared Neighborhood Hits	115
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

ITK_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.054256 (rank : 602)
Query Neighborhood Hits	554	Target Neighborhood Hits	985	Shared Neighborhood Hits	122
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

IWS1_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.056440 (rank : 568)
Query Neighborhood Hits	554	Target Neighborhood Hits	1258	Shared Neighborhood Hits	151
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JIP1_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.076778 (rank : 385)
Query Neighborhood Hits	554	Target Neighborhood Hits	271	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.076170 (rank : 388)
Query Neighborhood Hits	554	Target Neighborhood Hits	259	Shared Neighborhood Hits	107
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.065728 (rank : 477)
Query Neighborhood Hits	554	Target Neighborhood Hits	288	Shared Neighborhood Hits	94
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.052283 (rank : 628)
Query Neighborhood Hits	554	Target Neighborhood Hits	144	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JPH2_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.059170 (rank : 536)
Query Neighborhood Hits	554	Target Neighborhood Hits	639	Shared Neighborhood Hits	147
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

K1543_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.066496 (rank : 471)
Query Neighborhood Hits	554	Target Neighborhood Hits	435	Shared Neighborhood Hits	122
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1543_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.070273 (rank : 440)
Query Neighborhood Hits	554	Target Neighborhood Hits	497	Shared Neighborhood Hits	137
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1683_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.057491 (rank : 555)
Query Neighborhood Hits	554	Target Neighborhood Hits	240	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

K1688_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.056383 (rank : 569)
Query Neighborhood Hits	554	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

K1802_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.085293 (rank : 344)
Query Neighborhood Hits	554	Target Neighborhood Hits	1378	Shared Neighborhood Hits	206
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LBC_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.052198 (rank : 630)
Query Neighborhood Hits	554	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.065212 (rank : 482)
Query Neighborhood Hits	554	Target Neighborhood Hits	987	Shared Neighborhood Hits	119
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.064463 (rank : 488)
Query Neighborhood Hits	554	Target Neighborhood Hits	981	Shared Neighborhood Hits	117
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.069705 (rank : 444)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	63
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.053821 (rank : 609)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MAML2_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.053729 (rank : 611)
Query Neighborhood Hits	554	Target Neighborhood Hits	360	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

MAML3_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.053292 (rank : 616)
Query Neighborhood Hits	554	Target Neighborhood Hits	323	Shared Neighborhood Hits	74
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

MAP1A_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.066434 (rank : 472)
Query Neighborhood Hits	554	Target Neighborhood Hits	1626	Shared Neighborhood Hits	206
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MAVS_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.054484 (rank : 598)
Query Neighborhood Hits	554	Target Neighborhood Hits	271	Shared Neighborhood Hits	75
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MBB1A_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.055252 (rank : 588)
Query Neighborhood Hits	554	Target Neighborhood Hits	665	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

MCF2_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.077008 (rank : 383)
Query Neighborhood Hits	554	Target Neighborhood Hits	166	Shared Neighborhood Hits	26
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MDC1_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.133298 (rank : 209)
Query Neighborhood Hits	554	Target Neighborhood Hits	1446	Shared Neighborhood Hits	217
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.130499 (rank : 216)
Query Neighborhood Hits	554	Target Neighborhood Hits	998	Shared Neighborhood Hits	200
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MEF2B_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.052096 (rank : 632)
Query Neighborhood Hits	554	Target Neighborhood Hits	218	Shared Neighborhood Hits	73
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

MEGF9_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.052054 (rank : 634)
Query Neighborhood Hits	554	Target Neighborhood Hits	896	Shared Neighborhood Hits	160
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MILK1_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.072983 (rank : 409)
Query Neighborhood Hits	554	Target Neighborhood Hits	788	Shared Neighborhood Hits	180
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MINT_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.065369 (rank : 480)
Query Neighborhood Hits	554	Target Neighborhood Hits	1291	Shared Neighborhood Hits	160
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MINT_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.092363 (rank : 317)
Query Neighborhood Hits	554	Target Neighborhood Hits	1514	Shared Neighborhood Hits	223
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MNT_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.076749 (rank : 386)
Query Neighborhood Hits	554	Target Neighborhood Hits	432	Shared Neighborhood Hits	87
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MTSS1_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.068082 (rank : 458)
Query Neighborhood Hits	554	Target Neighborhood Hits	504	Shared Neighborhood Hits	120
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

MTSS1_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.095497 (rank : 309)
Query Neighborhood Hits	554	Target Neighborhood Hits	592	Shared Neighborhood Hits	153
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MUC1_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.196361 (rank : 120)
Query Neighborhood Hits	554	Target Neighborhood Hits	975	Shared Neighborhood Hits	231
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MYO15_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.070432 (rank : 438)
Query Neighborhood Hits	554	Target Neighborhood Hits	671	Shared Neighborhood Hits	208
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NCOR2_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.054160 (rank : 603)
Query Neighborhood Hits	554	Target Neighborhood Hits	870	Shared Neighborhood Hits	128
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NFH_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.075767 (rank : 391)
Query Neighborhood Hits	554	Target Neighborhood Hits	2247	Shared Neighborhood Hits	232
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NGEF_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.099809 (rank : 285)
Query Neighborhood Hits	554	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.104634 (rank : 270)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NRX2B_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.069829 (rank : 443)
Query Neighborhood Hits	554	Target Neighborhood Hits	481	Shared Neighborhood Hits	147
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

NU214_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.058241 (rank : 549)
Query Neighborhood Hits	554	Target Neighborhood Hits	657	Shared Neighborhood Hits	107
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

NUMBL_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.084026 (rank : 352)
Query Neighborhood Hits	554	Target Neighborhood Hits	394	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

NUP53_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.050977 (rank : 645)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

OGFR_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.073917 (rank : 404)
Query Neighborhood Hits	554	Target Neighborhood Hits	584	Shared Neighborhood Hits	104
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

P55G_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.053229 (rank : 617)
Query Neighborhood Hits	554	Target Neighborhood Hits	451	Shared Neighborhood Hits	58
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 717)	NC score	0.051825 (rank : 639)
Query Neighborhood Hits	554	Target Neighborhood Hits	401	Shared Neighborhood Hits	55
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 718)	NC score	0.085724 (rank : 342)
Query Neighborhood Hits	554	Target Neighborhood Hits	479	Shared Neighborhood Hits	104
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.089967 (rank : 322)
Query Neighborhood Hits	554	Target Neighborhood Hits	435	Shared Neighborhood Hits	107
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.074735 (rank : 398)
Query Neighborhood Hits	554	Target Neighborhood Hits	543	Shared Neighborhood Hits	91
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.067253 (rank : 466)
Query Neighborhood Hits	554	Target Neighborhood Hits	519	Shared Neighborhood Hits	83
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCQAP_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.081831 (rank : 361)
Query Neighborhood Hits	554	Target Neighborhood Hits	549	Shared Neighborhood Hits	97
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PER2_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.058594 (rank : 544)
Query Neighborhood Hits	554	Target Neighborhood Hits	325	Shared Neighborhood Hits	104
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.069104 (rank : 448)
Query Neighborhood Hits	554	Target Neighborhood Hits	479	Shared Neighborhood Hits	137
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PHLB1_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.056872 (rank : 564)
Query Neighborhood Hits	554	Target Neighborhood Hits	1038	Shared Neighborhood Hits	150
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PI5PA_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.096946 (rank : 304)
Query Neighborhood Hits	554	Target Neighborhood Hits	749	Shared Neighborhood Hits	198
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PKHG1_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.088601 (rank : 330)
Query Neighborhood Hits	554	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.058710 (rank : 542)
Query Neighborhood Hits	554	Target Neighborhood Hits	200	Shared Neighborhood Hits	43
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.071740 (rank : 426)
Query Neighborhood Hits	554	Target Neighborhood Hits	254	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.068988 (rank : 451)
Query Neighborhood Hits	554	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PRB3_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.104170 (rank : 271)
Query Neighborhood Hits	554	Target Neighborhood Hits	318	Shared Neighborhood Hits	77
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PREX1_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.084409 (rank : 350)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP5_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.051002 (rank : 644)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	26
SwissProt Accessions	P04281	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide IB-1.

PRPC_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.070058 (rank : 441)
Query Neighborhood Hits	554	Target Neighborhood Hits	165	Shared Neighborhood Hits	42
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

PRR13_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.078649 (rank : 376)
Query Neighborhood Hits	554	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

PRR13_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.078682 (rank : 375)
Query Neighborhood Hits	554	Target Neighborhood Hits	54	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CQJ5, Q3U3U4	Gene names	Prr13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

PSL1_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.102987 (rank : 275)
Query Neighborhood Hits	554	Target Neighborhood Hits	650	Shared Neighborhood Hits	194
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PYGO2_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.056025 (rank : 578)
Query Neighborhood Hits	554	Target Neighborhood Hits	189	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

RASA1_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.072741 (rank : 411)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	67
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RGNEF_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.057792 (rank : 552)
Query Neighborhood Hits	554	Target Neighborhood Hits	641	Shared Neighborhood Hits	62
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SASH1_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.065726 (rank : 478)
Query Neighborhood Hits	554	Target Neighborhood Hits	292	Shared Neighborhood Hits	103
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.064325 (rank : 489)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	84
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SC24A_MOUSE
θ value	θ > 10 (rank : 743)	NC score	0.087953 (rank : 335)
Query Neighborhood Hits	554	Target Neighborhood Hits	394	Shared Neighborhood Hits	156
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SC24C_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.130630 (rank : 215)
Query Neighborhood Hits	554	Target Neighborhood Hits	662	Shared Neighborhood Hits	201
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SELPL_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.099302 (rank : 292)
Query Neighborhood Hits	554	Target Neighborhood Hits	588	Shared Neighborhood Hits	149
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SEPT9_HUMAN
θ value	θ > 10 (rank : 746)	NC score	0.062305 (rank : 510)
Query Neighborhood Hits	554	Target Neighborhood Hits	706	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SFR15_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.059713 (rank : 531)
Query Neighborhood Hits	554	Target Neighborhood Hits	368	Shared Neighborhood Hits	74
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SH21B_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.063657 (rank : 496)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.064318 (rank : 490)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.058076 (rank : 551)
Query Neighborhood Hits	554	Target Neighborhood Hits	179	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SHAN2_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.135925 (rank : 205)
Query Neighborhood Hits	554	Target Neighborhood Hits	446	Shared Neighborhood Hits	140
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.052431 (rank : 627)
Query Neighborhood Hits	554	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.053519 (rank : 615)
Query Neighborhood Hits	554	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.056889 (rank : 563)
Query Neighborhood Hits	554	Target Neighborhood Hits	180	Shared Neighborhood Hits	61
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.055760 (rank : 581)
Query Neighborhood Hits	554	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.054407 (rank : 599)
Query Neighborhood Hits	554	Target Neighborhood Hits	144	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.054304 (rank : 601)
Query Neighborhood Hits	554	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.058288 (rank : 548)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.056315 (rank : 572)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.051235 (rank : 643)
Query Neighborhood Hits	554	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.053777 (rank : 610)
Query Neighborhood Hits	554	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.055038 (rank : 593)
Query Neighborhood Hits	554	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB2_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.120071 (rank : 235)
Query Neighborhood Hits	554	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.121189 (rank : 233)
Query Neighborhood Hits	554	Target Neighborhood Hits	88	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.087013 (rank : 336)
Query Neighborhood Hits	554	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.084761 (rank : 347)
Query Neighborhood Hits	554	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.099685 (rank : 287)
Query Neighborhood Hits	554	Target Neighborhood Hits	139	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.096861 (rank : 305)
Query Neighborhood Hits	554	Target Neighborhood Hits	136	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.071154 (rank : 428)
Query Neighborhood Hits	554	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.080662 (rank : 367)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SMR3A_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.064677 (rank : 486)
Query Neighborhood Hits	554	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

SNPC4_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.089848 (rank : 323)
Query Neighborhood Hits	554	Target Neighborhood Hits	589	Shared Neighborhood Hits	162
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SNX9_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.141881 (rank : 187)
Query Neighborhood Hits	554	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.130776 (rank : 213)
Query Neighborhood Hits	554	Target Neighborhood Hits	141	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOX30_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.054963 (rank : 595)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	131
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

SPR1A_MOUSE
θ value	θ > 10 (rank : 776)	NC score	0.072340 (rank : 421)
Query Neighborhood Hits	554	Target Neighborhood Hits	343	Shared Neighborhood Hits	120
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SPR1B_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.099145 (rank : 294)
Query Neighborhood Hits	554	Target Neighborhood Hits	395	Shared Neighborhood Hits	135
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SPRR3_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.056599 (rank : 566)
Query Neighborhood Hits	554	Target Neighborhood Hits	102	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

SRBP1_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.051892 (rank : 636)
Query Neighborhood Hits	554	Target Neighborhood Hits	384	Shared Neighborhood Hits	115
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRMS_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.051872 (rank : 637)
Query Neighborhood Hits	554	Target Neighborhood Hits	946	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.057727 (rank : 553)
Query Neighborhood Hits	554	Target Neighborhood Hits	964	Shared Neighborhood Hits	110
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRRM1_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.114315 (rank : 248)
Query Neighborhood Hits	554	Target Neighborhood Hits	966	Shared Neighborhood Hits	177
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.067984 (rank : 459)
Query Neighborhood Hits	554	Target Neighborhood Hits	1296	Shared Neighborhood Hits	164
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
θ value	θ > 10 (rank : 784)	NC score	0.089197 (rank : 327)
Query Neighborhood Hits	554	Target Neighborhood Hits	1470	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SSBP4_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.126814 (rank : 222)
Query Neighborhood Hits	554	Target Neighborhood Hits	753	Shared Neighborhood Hits	206
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC3_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.245260 (rank : 103)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	140
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.246007 (rank : 102)
Query Neighborhood Hits	554	Target Neighborhood Hits	232	Shared Neighborhood Hits	140
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STS1_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.077269 (rank : 380)
Query Neighborhood Hits	554	Target Neighborhood Hits	106	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 789)	NC score	0.077251 (rank : 381)
Query Neighborhood Hits	554	Target Neighborhood Hits	104	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.099374 (rank : 290)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	72
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SYNJ1_MOUSE
θ value	θ > 10 (rank : 791)	NC score	0.056255 (rank : 573)
Query Neighborhood Hits	554	Target Neighborhood Hits	516	Shared Neighborhood Hits	137
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SYNPO_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.061082 (rank : 520)
Query Neighborhood Hits	554	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

SYP2L_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.057364 (rank : 556)
Query Neighborhood Hits	554	Target Neighborhood Hits	400	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

T22D4_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.081980 (rank : 359)
Query Neighborhood Hits	554	Target Neighborhood Hits	403	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TAB3_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.058906 (rank : 538)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

TAB3_MOUSE
θ value	θ > 10 (rank : 796)	NC score	0.088517 (rank : 331)
Query Neighborhood Hits	554	Target Neighborhood Hits	273	Shared Neighborhood Hits	87
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

TARA_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.079965 (rank : 371)
Query Neighborhood Hits	554	Target Neighborhood Hits	1626	Shared Neighborhood Hits	203
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TAU_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.052185 (rank : 631)
Query Neighborhood Hits	554	Target Neighborhood Hits	502	Shared Neighborhood Hits	100
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TEC_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.064183 (rank : 492)
Query Neighborhood Hits	554	Target Neighborhood Hits	1006	Shared Neighborhood Hits	143
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.063155 (rank : 500)
Query Neighborhood Hits	554	Target Neighborhood Hits	1006	Shared Neighborhood Hits	142
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TENS1_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.052741 (rank : 623)
Query Neighborhood Hits	554	Target Neighborhood Hits	400	Shared Neighborhood Hits	107
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TENS4_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.056930 (rank : 560)
Query Neighborhood Hits	554	Target Neighborhood Hits	214	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TGON2_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.063302 (rank : 499)
Query Neighborhood Hits	554	Target Neighborhood Hits	1037	Shared Neighborhood Hits	134
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TIAM1_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.082956 (rank : 355)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.082126 (rank : 357)
Query Neighborhood Hits	554	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TM108_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.069891 (rank : 442)
Query Neighborhood Hits	554	Target Neighborhood Hits	336	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TP53B_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.056901 (rank : 561)
Query Neighborhood Hits	554	Target Neighborhood Hits	644	Shared Neighborhood Hits	101
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TPO_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.096237 (rank : 307)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	103
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

TROAP_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.078031 (rank : 378)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

TULP4_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.081832 (rank : 360)
Query Neighborhood Hits	554	Target Neighborhood Hits	426	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

WASP_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.078839 (rank : 373)
Query Neighborhood Hits	554	Target Neighborhood Hits	195	Shared Neighborhood Hits	63
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

WASP_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.078476 (rank : 377)
Query Neighborhood Hits	554	Target Neighborhood Hits	223	Shared Neighborhood Hits	62
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

WBP11_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.090810 (rank : 318)
Query Neighborhood Hits	554	Target Neighborhood Hits	362	Shared Neighborhood Hits	79
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

WBS14_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.075573 (rank : 392)
Query Neighborhood Hits	554	Target Neighborhood Hits	273	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

ZIM10_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.073565 (rank : 407)
Query Neighborhood Hits	554	Target Neighborhood Hits	430	Shared Neighborhood Hits	129
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZIMP7_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.050446 (rank : 648)
Query Neighborhood Hits	554	Target Neighborhood Hits	290	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZN207_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.068814 (rank : 452)
Query Neighborhood Hits	554	Target Neighborhood Hits	326	Shared Neighborhood Hits	58
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

ZN385_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.076855 (rank : 384)
Query Neighborhood Hits	554	Target Neighborhood Hits	614	Shared Neighborhood Hits	143
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZN645_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.084352 (rank : 351)
Query Neighborhood Hits	554	Target Neighborhood Hits	265	Shared Neighborhood Hits	97
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

Hits sorted by NC score

BCAR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	554	Target Neighborhood Hits	554	Shared Neighborhood Hits	554
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
NC score	0.956575 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	554	Target Neighborhood Hits	438	Shared Neighborhood Hits	362
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_MOUSE
NC score	0.863761 (rank : 3)	θ value	3.39372e-140 (rank : 3)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	166
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.860937 (rank : 4)	θ value	5.41814e-138 (rank : 4)
Query Neighborhood Hits	554	Target Neighborhood Hits	259	Shared Neighborhood Hits	178
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CT032_HUMAN
NC score	0.762174 (rank : 5)	θ value	2.27234e-27 (rank : 7)
Query Neighborhood Hits	554	Target Neighborhood Hits	235	Shared Neighborhood Hits	156
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

EFS_HUMAN
NC score	0.726437 (rank : 6)	θ value	1.52067e-31 (rank : 5)
Query Neighborhood Hits	554	Target Neighborhood Hits	348	Shared Neighborhood Hits	211
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
NC score	0.719967 (rank : 7)	θ value	5.40856e-29 (rank : 6)
Query Neighborhood Hits	554	Target Neighborhood Hits	389	Shared Neighborhood Hits	231
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CD2AP_MOUSE
NC score	0.481584 (rank : 8)	θ value	9.92553e-07 (rank : 11)
Query Neighborhood Hits	554	Target Neighborhood Hits	336	Shared Neighborhood Hits	188
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

HCLS1_HUMAN
NC score	0.465190 (rank : 9)	θ value	1.87187e-05 (rank : 20)
Query Neighborhood Hits	554	Target Neighborhood Hits	358	Shared Neighborhood Hits	220
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

CD2AP_HUMAN
NC score	0.464818 (rank : 10)	θ value	4.1701e-05 (rank : 25)
Query Neighborhood Hits	554	Target Neighborhood Hits	315	Shared Neighborhood Hits	180
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.464245 (rank : 11)	θ value	1.29631e-06 (rank : 12)
Query Neighborhood Hits	554	Target Neighborhood Hits	332	Shared Neighborhood Hits	177
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.461250 (rank : 12)	θ value	6.43352e-06 (rank : 16)
Query Neighborhood Hits	554	Target Neighborhood Hits	341	Shared Neighborhood Hits	171
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

HCLS1_MOUSE
NC score	0.440587 (rank : 13)	θ value	0.00035302 (rank : 45)
Query Neighborhood Hits	554	Target Neighborhood Hits	329	Shared Neighborhood Hits	201
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PPIP1_HUMAN
NC score	0.432120 (rank : 14)	θ value	4.45536e-07 (rank : 9)
Query Neighborhood Hits	554	Target Neighborhood Hits	389	Shared Neighborhood Hits	175
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.428747 (rank : 15)	θ value	2.88788e-06 (rank : 13)
Query Neighborhood Hits	554	Target Neighborhood Hits	377	Shared Neighborhood Hits	170
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PEX13_MOUSE
NC score	0.426211 (rank : 16)	θ value	8.40245e-06 (rank : 17)
Query Neighborhood Hits	554	Target Neighborhood Hits	126	Shared Neighborhood Hits	109
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_HUMAN
NC score	0.423531 (rank : 17)	θ value	2.44474e-05 (rank : 23)
Query Neighborhood Hits	554	Target Neighborhood Hits	128	Shared Neighborhood Hits	110
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SRC8_MOUSE
NC score	0.403415 (rank : 18)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	554	Target Neighborhood Hits	292	Shared Neighborhood Hits	169
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.402873 (rank : 19)	θ value	0.000158464 (rank : 30)
Query Neighborhood Hits	554	Target Neighborhood Hits	269	Shared Neighborhood Hits	165
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SH3G2_MOUSE
NC score	0.397953 (rank : 20)	θ value	0.000270298 (rank : 39)
Query Neighborhood Hits	554	Target Neighborhood Hits	319	Shared Neighborhood Hits	166
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

VINEX_MOUSE
NC score	0.397618 (rank : 21)	θ value	0.00390308 (rank : 74)
Query Neighborhood Hits	554	Target Neighborhood Hits	286	Shared Neighborhood Hits	173
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCF2_HUMAN
NC score	0.396532 (rank : 22)	θ value	0.365318 (rank : 245)
Query Neighborhood Hits	554	Target Neighborhood Hits	229	Shared Neighborhood Hits	149
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_HUMAN
NC score	0.390302 (rank : 23)	θ value	0.00869519 (rank : 91)
Query Neighborhood Hits	554	Target Neighborhood Hits	270	Shared Neighborhood Hits	165
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3G2_HUMAN
NC score	0.390188 (rank : 24)	θ value	0.000461057 (rank : 47)
Query Neighborhood Hits	554	Target Neighborhood Hits	324	Shared Neighborhood Hits	163
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

ABI2_HUMAN
NC score	0.389557 (rank : 25)	θ value	0.00390308 (rank : 65)
Query Neighborhood Hits	554	Target Neighborhood Hits	350	Shared Neighborhood Hits	187
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.382878 (rank : 26)	θ value	0.00390308 (rank : 66)
Query Neighborhood Hits	554	Target Neighborhood Hits	266	Shared Neighborhood Hits	167
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

GRAP2_MOUSE
NC score	0.379513 (rank : 27)	θ value	0.00035302 (rank : 44)
Query Neighborhood Hits	554	Target Neighborhood Hits	297	Shared Neighborhood Hits	178
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3G1_MOUSE
NC score	0.378406 (rank : 28)	θ value	0.00102713 (rank : 52)
Query Neighborhood Hits	554	Target Neighborhood Hits	291	Shared Neighborhood Hits	161
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
NC score	0.373774 (rank : 29)	θ value	0.00869519 (rank : 89)
Query Neighborhood Hits	554	Target Neighborhood Hits	222	Shared Neighborhood Hits	155
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

NCK1_HUMAN
NC score	0.371623 (rank : 30)	θ value	0.000602161 (rank : 48)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	172
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRB2_HUMAN
NC score	0.371430 (rank : 31)	θ value	0.000270298 (rank : 35)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	175
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.371066 (rank : 32)	θ value	0.000270298 (rank : 36)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	175
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

IASPP_MOUSE
NC score	0.370331 (rank : 33)	θ value	1.53129e-07 (rank : 8)
Query Neighborhood Hits	554	Target Neighborhood Hits	1024	Shared Neighborhood Hits	324
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRBS1_MOUSE
NC score	0.368951 (rank : 34)	θ value	0.0252991 (rank : 125)
Query Neighborhood Hits	554	Target Neighborhood Hits	409	Shared Neighborhood Hits	187
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G3_MOUSE
NC score	0.368607 (rank : 35)	θ value	0.0431538 (rank : 145)
Query Neighborhood Hits	554	Target Neighborhood Hits	236	Shared Neighborhood Hits	160
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NCF1_HUMAN
NC score	0.368229 (rank : 36)	θ value	0.0736092 (rank : 168)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	143
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

GRAP2_HUMAN
NC score	0.368135 (rank : 37)	θ value	0.00134147 (rank : 54)
Query Neighborhood Hits	554	Target Neighborhood Hits	304	Shared Neighborhood Hits	180
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SRBS1_HUMAN
NC score	0.360721 (rank : 38)	θ value	0.0148317 (rank : 102)
Query Neighborhood Hits	554	Target Neighborhood Hits	396	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCK2_HUMAN
NC score	0.358592 (rank : 39)	θ value	0.00175202 (rank : 56)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	173
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG7_HUMAN
NC score	0.358142 (rank : 40)	θ value	1.87187e-05 (rank : 19)
Query Neighborhood Hits	554	Target Neighborhood Hits	347	Shared Neighborhood Hits	167
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

IASPP_HUMAN
NC score	0.355697 (rank : 41)	θ value	5.81887e-07 (rank : 10)
Query Neighborhood Hits	554	Target Neighborhood Hits	688	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NCF1_MOUSE
NC score	0.355216 (rank : 42)	θ value	0.0961366 (rank : 183)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	150
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

GRAP_MOUSE
NC score	0.355198 (rank : 43)	θ value	0.00390308 (rank : 70)
Query Neighborhood Hits	554	Target Neighborhood Hits	309	Shared Neighborhood Hits	177
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SH3G1_HUMAN
NC score	0.352334 (rank : 44)	θ value	0.0330416 (rank : 135)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	158
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI1_MOUSE
NC score	0.351008 (rank : 45)	θ value	0.0563607 (rank : 149)
Query Neighborhood Hits	554	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

DNMBP_HUMAN
NC score	0.350250 (rank : 46)	θ value	0.00390308 (rank : 69)
Query Neighborhood Hits	554	Target Neighborhood Hits	413	Shared Neighborhood Hits	181
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
NC score	0.350203 (rank : 47)	θ value	0.00035302 (rank : 43)
Query Neighborhood Hits	554	Target Neighborhood Hits	396	Shared Neighborhood Hits	169
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP_HUMAN
NC score	0.348759 (rank : 48)	θ value	0.00869519 (rank : 85)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	181
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCF4_MOUSE
NC score	0.346620 (rank : 49)	θ value	0.125558 (rank : 198)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	137
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_HUMAN
NC score	0.341815 (rank : 50)	θ value	0.0431538 (rank : 146)
Query Neighborhood Hits	554	Target Neighborhood Hits	271	Shared Neighborhood Hits	176
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.341711 (rank : 51)	θ value	0.0431538 (rank : 147)
Query Neighborhood Hits	554	Target Neighborhood Hits	273	Shared Neighborhood Hits	179
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
NC score	0.340924 (rank : 52)	θ value	0.0563607 (rank : 155)
Query Neighborhood Hits	554	Target Neighborhood Hits	276	Shared Neighborhood Hits	160
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DNMBP_MOUSE
NC score	0.340574 (rank : 53)	θ value	0.0113563 (rank : 94)
Query Neighborhood Hits	554	Target Neighborhood Hits	435	Shared Neighborhood Hits	192
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAM2_MOUSE
NC score	0.340050 (rank : 54)	θ value	0.0563607 (rank : 156)
Query Neighborhood Hits	554	Target Neighborhood Hits	285	Shared Neighborhood Hits	177
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABI1_HUMAN
NC score	0.338951 (rank : 55)	θ value	0.0961366 (rank : 176)
Query Neighborhood Hits	554	Target Neighborhood Hits	257	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PACN2_HUMAN
NC score	0.333171 (rank : 56)	θ value	0.0330416 (rank : 133)
Query Neighborhood Hits	554	Target Neighborhood Hits	339	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CRKL_HUMAN
NC score	0.330931 (rank : 57)	θ value	0.0148317 (rank : 99)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	174
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

PACN2_MOUSE
NC score	0.330043 (rank : 58)	θ value	0.0563607 (rank : 152)
Query Neighborhood Hits	554	Target Neighborhood Hits	382	Shared Neighborhood Hits	168
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.326759 (rank : 59)	θ value	0.0961366 (rank : 186)
Query Neighborhood Hits	554	Target Neighborhood Hits	283	Shared Neighborhood Hits	158
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAC_MOUSE
NC score	0.325523 (rank : 60)	θ value	0.21417 (rank : 220)
Query Neighborhood Hits	554	Target Neighborhood Hits	268	Shared Neighborhood Hits	158
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PACN1_HUMAN
NC score	0.324834 (rank : 61)	θ value	0.0961366 (rank : 185)
Query Neighborhood Hits	554	Target Neighborhood Hits	320	Shared Neighborhood Hits	160
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ARHG6_MOUSE
NC score	0.321992 (rank : 62)	θ value	0.0736092 (rank : 160)
Query Neighborhood Hits	554	Target Neighborhood Hits	394	Shared Neighborhood Hits	163
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ASPP1_MOUSE
NC score	0.318428 (rank : 63)	θ value	1.09739e-05 (rank : 18)
Query Neighborhood Hits	554	Target Neighborhood Hits	1244	Shared Neighborhood Hits	300
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NCF4_HUMAN
NC score	0.317700 (rank : 64)	θ value	1.81305 (rank : 361)
Query Neighborhood Hits	554	Target Neighborhood Hits	161	Shared Neighborhood Hits	124
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NPHP1_MOUSE
NC score	0.317291 (rank : 65)	θ value	0.00869519 (rank : 86)
Query Neighborhood Hits	554	Target Neighborhood Hits	267	Shared Neighborhood Hits	151
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAM2_HUMAN
NC score	0.317187 (rank : 66)	θ value	0.279714 (rank : 231)
Query Neighborhood Hits	554	Target Neighborhood Hits	288	Shared Neighborhood Hits	176
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ARHG6_HUMAN
NC score	0.315685 (rank : 67)	θ value	0.0736092 (rank : 159)
Query Neighborhood Hits	554	Target Neighborhood Hits	376	Shared Neighborhood Hits	162
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PACN3_MOUSE
NC score	0.315654 (rank : 68)	θ value	0.0563607 (rank : 154)
Query Neighborhood Hits	554	Target Neighborhood Hits	380	Shared Neighborhood Hits	153
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CRK_MOUSE
NC score	0.315262 (rank : 69)	θ value	0.279714 (rank : 226)
Query Neighborhood Hits	554	Target Neighborhood Hits	314	Shared Neighborhood Hits	175
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PACN3_HUMAN
NC score	0.312725 (rank : 70)	θ value	0.0563607 (rank : 153)
Query Neighborhood Hits	554	Target Neighborhood Hits	385	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

CRKL_MOUSE
NC score	0.310392 (rank : 71)	θ value	0.0961366 (rank : 178)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	167
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

VAV_HUMAN
NC score	0.304448 (rank : 72)	θ value	0.00020696 (rank : 33)
Query Neighborhood Hits	554	Target Neighborhood Hits	452	Shared Neighborhood Hits	168
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.303092 (rank : 73)	θ value	0.000270298 (rank : 41)
Query Neighborhood Hits	554	Target Neighborhood Hits	430	Shared Neighborhood Hits	167
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

OSTF1_HUMAN
NC score	0.299247 (rank : 74)	θ value	0.0113563 (rank : 95)
Query Neighborhood Hits	554	Target Neighborhood Hits	466	Shared Neighborhood Hits	172
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.298388 (rank : 75)	θ value	0.00869519 (rank : 87)
Query Neighborhood Hits	554	Target Neighborhood Hits	467	Shared Neighborhood Hits	173
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ASPP1_HUMAN
NC score	0.295951 (rank : 76)	θ value	3.77169e-06 (rank : 14)
Query Neighborhood Hits	554	Target Neighborhood Hits	956	Shared Neighborhood Hits	213
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

RUSC1_HUMAN
NC score	0.295475 (rank : 77)	θ value	0.00390308 (rank : 73)
Query Neighborhood Hits	554	Target Neighborhood Hits	226	Shared Neighborhood Hits	144
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

CRK_HUMAN
NC score	0.294253 (rank : 78)	θ value	4.03905 (rank : 435)
Query Neighborhood Hits	554	Target Neighborhood Hits	308	Shared Neighborhood Hits	172
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NPHP1_HUMAN
NC score	0.289943 (rank : 79)	θ value	0.0252991 (rank : 122)
Query Neighborhood Hits	554	Target Neighborhood Hits	288	Shared Neighborhood Hits	143
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

AHI1_HUMAN
NC score	0.289683 (rank : 80)	θ value	0.00035302 (rank : 42)
Query Neighborhood Hits	554	Target Neighborhood Hits	537	Shared Neighborhood Hits	169
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ITSN2_HUMAN
NC score	0.281427 (rank : 81)	θ value	0.000121331 (rank : 27)
Query Neighborhood Hits	554	Target Neighborhood Hits	1173	Shared Neighborhood Hits	194
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_HUMAN
NC score	0.280642 (rank : 82)	θ value	5.44631e-05 (rank : 26)
Query Neighborhood Hits	554	Target Neighborhood Hits	1757	Shared Neighborhood Hits	266
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.280471 (rank : 83)	θ value	6.43352e-06 (rank : 15)
Query Neighborhood Hits	554	Target Neighborhood Hits	1669	Shared Neighborhood Hits	245
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

AHI1_MOUSE
NC score	0.278289 (rank : 84)	θ value	0.0193708 (rank : 106)
Query Neighborhood Hits	554	Target Neighborhood Hits	496	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NOXO1_MOUSE
NC score	0.269074 (rank : 85)	θ value	0.0330416 (rank : 132)
Query Neighborhood Hits	554	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ITSN2_MOUSE
NC score	0.266563 (rank : 86)	θ value	0.00035302 (rank : 46)
Query Neighborhood Hits	554	Target Neighborhood Hits	1371	Shared Neighborhood Hits	199
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DBNL_MOUSE
NC score	0.264347 (rank : 87)	θ value	8.99809 (rank : 525)
Query Neighborhood Hits	554	Target Neighborhood Hits	306	Shared Neighborhood Hits	152
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

LASP1_HUMAN
NC score	0.264243 (rank : 88)	θ value	1.81305 (rank : 353)
Query Neighborhood Hits	554	Target Neighborhood Hits	293	Shared Neighborhood Hits	148
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

DBNL_HUMAN
NC score	0.263689 (rank : 89)	θ value	8.99809 (rank : 524)
Query Neighborhood Hits	554	Target Neighborhood Hits	244	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ABI3_MOUSE
NC score	0.262917 (rank : 90)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	158
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

RUSC1_MOUSE
NC score	0.261603 (rank : 91)	θ value	0.0431538 (rank : 142)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ARHG9_HUMAN
NC score	0.261421 (rank : 92)	θ value	0.00390308 (rank : 67)
Query Neighborhood Hits	554	Target Neighborhood Hits	235	Shared Neighborhood Hits	145
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

LASP1_MOUSE
NC score	0.261381 (rank : 93)	θ value	1.81305 (rank : 354)
Query Neighborhood Hits	554	Target Neighborhood Hits	297	Shared Neighborhood Hits	146
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NEBL_HUMAN
NC score	0.261358 (rank : 94)	θ value	0.0961366 (rank : 184)
Query Neighborhood Hits	554	Target Neighborhood Hits	457	Shared Neighborhood Hits	149
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ABI3_HUMAN
NC score	0.260071 (rank : 95)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	162
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG9_MOUSE
NC score	0.259257 (rank : 96)	θ value	0.00869519 (rank : 84)
Query Neighborhood Hits	554	Target Neighborhood Hits	234	Shared Neighborhood Hits	145
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

SNX18_MOUSE
NC score	0.250542 (rank : 97)	θ value	0.0736092 (rank : 173)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV2_MOUSE
NC score	0.249502 (rank : 98)	θ value	1.06291 (rank : 323)
Query Neighborhood Hits	554	Target Neighborhood Hits	456	Shared Neighborhood Hits	171
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.249099 (rank : 99)	θ value	1.06291 (rank : 322)
Query Neighborhood Hits	554	Target Neighborhood Hits	453	Shared Neighborhood Hits	168
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

TCGAP_HUMAN
NC score	0.248133 (rank : 100)	θ value	0.00298849 (rank : 64)
Query Neighborhood Hits	554	Target Neighborhood Hits	872	Shared Neighborhood Hits	300
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ASPP2_HUMAN
NC score	0.247851 (rank : 101)	θ value	0.000270298 (rank : 34)
Query Neighborhood Hits	554	Target Neighborhood Hits	1156	Shared Neighborhood Hits	218
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

STAC3_MOUSE
NC score	0.246007 (rank : 102)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	554	Target Neighborhood Hits	232	Shared Neighborhood Hits	140
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.245260 (rank : 103)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	140
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG4_HUMAN
NC score	0.243372 (rank : 104)	θ value	0.279714 (rank : 225)
Query Neighborhood Hits	554	Target Neighborhood Hits	242	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SNX18_HUMAN
NC score	0.240194 (rank : 105)	θ value	0.0961366 (rank : 189)
Query Neighborhood Hits	554	Target Neighborhood Hits	207	Shared Neighborhood Hits	126
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV3_HUMAN
NC score	0.238401 (rank : 106)	θ value	0.365318 (rank : 251)
Query Neighborhood Hits	554	Target Neighborhood Hits	398	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.231734 (rank : 107)	θ value	0.62314 (rank : 283)
Query Neighborhood Hits	554	Target Neighborhood Hits	404	Shared Neighborhood Hits	168
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

NEBU_HUMAN
NC score	0.227418 (rank : 108)	θ value	0.365318 (rank : 246)
Query Neighborhood Hits	554	Target Neighborhood Hits	420	Shared Neighborhood Hits	151
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RIMB2_HUMAN
NC score	0.223962 (rank : 109)	θ value	0.365318 (rank : 250)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	116
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ES8L3_MOUSE
NC score	0.219518 (rank : 110)	θ value	0.365318 (rank : 237)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	128
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RHG04_HUMAN
NC score	0.219279 (rank : 111)	θ value	0.0736092 (rank : 170)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB2_MOUSE
NC score	0.215437 (rank : 112)	θ value	0.279714 (rank : 230)
Query Neighborhood Hits	554	Target Neighborhood Hits	246	Shared Neighborhood Hits	104
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PRRT3_HUMAN
NC score	0.205341 (rank : 113)	θ value	2.36792 (rank : 389)
Query Neighborhood Hits	554	Target Neighborhood Hits	998	Shared Neighborhood Hits	254
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PLCG1_MOUSE
NC score	0.204830 (rank : 114)	θ value	3.0926 (rank : 413)
Query Neighborhood Hits	554	Target Neighborhood Hits	314	Shared Neighborhood Hits	149
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SON_HUMAN
NC score	0.204806 (rank : 115)	θ value	0.0252991 (rank : 124)
Query Neighborhood Hits	554	Target Neighborhood Hits	1568	Shared Neighborhood Hits	290
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NOXO1_HUMAN
NC score	0.203946 (rank : 116)	θ value	1.81305 (rank : 362)
Query Neighborhood Hits	554	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ES8L2_HUMAN
NC score	0.198991 (rank : 117)	θ value	0.0563607 (rank : 151)
Query Neighborhood Hits	554	Target Neighborhood Hits	193	Shared Neighborhood Hits	134
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_MOUSE
NC score	0.196865 (rank : 118)	θ value	0.0252991 (rank : 115)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	115
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

PLCG1_HUMAN
NC score	0.196722 (rank : 119)	θ value	3.0926 (rank : 412)
Query Neighborhood Hits	554	Target Neighborhood Hits	293	Shared Neighborhood Hits	144
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MUC1_HUMAN
NC score	0.196361 (rank : 120)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	554	Target Neighborhood Hits	975	Shared Neighborhood Hits	231
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PLCG2_HUMAN
NC score	0.195310 (rank : 121)	θ value	5.27518 (rank : 473)
Query Neighborhood Hits	554	Target Neighborhood Hits	280	Shared Neighborhood Hits	145
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NCOA6_HUMAN
NC score	0.194771 (rank : 122)	θ value	0.47712 (rank : 262)
Query Neighborhood Hits	554	Target Neighborhood Hits	1202	Shared Neighborhood Hits	280
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

DDEF1_MOUSE
NC score	0.194504 (rank : 123)	θ value	0.0736092 (rank : 162)
Query Neighborhood Hits	554	Target Neighborhood Hits	592	Shared Neighborhood Hits	197
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO1F_HUMAN
NC score	0.194475 (rank : 124)	θ value	1.87187e-05 (rank : 21)
Query Neighborhood Hits	554	Target Neighborhood Hits	275	Shared Neighborhood Hits	170
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.193208 (rank : 125)	θ value	1.87187e-05 (rank : 22)
Query Neighborhood Hits	554	Target Neighborhood Hits	262	Shared Neighborhood Hits	162
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

RGS3_MOUSE
NC score	0.193000 (rank : 126)	θ value	0.00175202 (rank : 57)
Query Neighborhood Hits	554	Target Neighborhood Hits	1621	Shared Neighborhood Hits	306
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

EPS8_HUMAN
NC score	0.192138 (rank : 127)	θ value	0.0330416 (rank : 129)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	109
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

OGFR_HUMAN
NC score	0.191557 (rank : 128)	θ value	0.0148317 (rank : 101)
Query Neighborhood Hits	554	Target Neighborhood Hits	1582	Shared Neighborhood Hits	292
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

DDEF2_MOUSE
NC score	0.191227 (rank : 129)	θ value	0.00509761 (rank : 77)
Query Neighborhood Hits	554	Target Neighborhood Hits	625	Shared Neighborhood Hits	179
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TCGAP_MOUSE
NC score	0.188088 (rank : 130)	θ value	0.00869519 (rank : 90)
Query Neighborhood Hits	554	Target Neighborhood Hits	409	Shared Neighborhood Hits	162
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ES8L2_MOUSE
NC score	0.186166 (rank : 131)	θ value	0.21417 (rank : 214)
Query Neighborhood Hits	554	Target Neighborhood Hits	169	Shared Neighborhood Hits	120
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SPT5H_HUMAN
NC score	0.186015 (rank : 132)	θ value	0.00509761 (rank : 80)
Query Neighborhood Hits	554	Target Neighborhood Hits	436	Shared Neighborhood Hits	147
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

DDEF2_HUMAN
NC score	0.185634 (rank : 133)	θ value	0.00509761 (rank : 76)
Query Neighborhood Hits	554	Target Neighborhood Hits	599	Shared Neighborhood Hits	175
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SPT5H_MOUSE
NC score	0.185598 (rank : 134)	θ value	0.00509761 (rank : 81)
Query Neighborhood Hits	554	Target Neighborhood Hits	437	Shared Neighborhood Hits	146
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SPTA2_HUMAN
NC score	0.182720 (rank : 135)	θ value	0.00020696 (rank : 32)
Query Neighborhood Hits	554	Target Neighborhood Hits	888	Shared Neighborhood Hits	171
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PRP2_MOUSE
NC score	0.180161 (rank : 136)	θ value	0.0330416 (rank : 134)
Query Neighborhood Hits	554	Target Neighborhood Hits	347	Shared Neighborhood Hits	97
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

MYO1E_HUMAN
NC score	0.180018 (rank : 137)	θ value	0.00020696 (rank : 31)
Query Neighborhood Hits	554	Target Neighborhood Hits	293	Shared Neighborhood Hits	170
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NACAM_MOUSE
NC score	0.180014 (rank : 138)	θ value	1.81305 (rank : 360)
Query Neighborhood Hits	554	Target Neighborhood Hits	1866	Shared Neighborhood Hits	296
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ARHG4_MOUSE
NC score	0.179991 (rank : 139)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	554	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SF3A2_MOUSE
NC score	0.179422 (rank : 140)	θ value	0.000121331 (rank : 28)
Query Neighborhood Hits	554	Target Neighborhood Hits	247	Shared Neighborhood Hits	84
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

BAT2_HUMAN
NC score	0.178938 (rank : 141)	θ value	0.00228821 (rank : 58)
Query Neighborhood Hits	554	Target Neighborhood Hits	931	Shared Neighborhood Hits	197
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SF3A2_HUMAN
NC score	0.178625 (rank : 142)	θ value	0.00134147 (rank : 55)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	87
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

RHG26_HUMAN
NC score	0.176418 (rank : 143)	θ value	0.163984 (rank : 207)
Query Neighborhood Hits	554	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L3_HUMAN
NC score	0.175529 (rank : 144)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

BCL9_HUMAN
NC score	0.174308 (rank : 145)	θ value	6.88961 (rank : 480)
Query Neighborhood Hits	554	Target Neighborhood Hits	1008	Shared Neighborhood Hits	267
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

WASIP_MOUSE
NC score	0.172792 (rank : 146)	θ value	0.0563607 (rank : 158)
Query Neighborhood Hits	554	Target Neighborhood Hits	392	Shared Neighborhood Hits	111
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

NCOA6_MOUSE
NC score	0.171966 (rank : 147)	θ value	0.62314 (rank : 277)
Query Neighborhood Hits	554	Target Neighborhood Hits	1076	Shared Neighborhood Hits	263
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

WASIP_HUMAN
NC score	0.171837 (rank : 148)	θ value	0.0252991 (rank : 126)
Query Neighborhood Hits	554	Target Neighborhood Hits	458	Shared Neighborhood Hits	112
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SRGP2_MOUSE
NC score	0.171263 (rank : 149)	θ value	1.06291 (rank : 320)
Query Neighborhood Hits	554	Target Neighborhood Hits	324	Shared Neighborhood Hits	146
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

MLL3_HUMAN
NC score	0.170293 (rank : 150)	θ value	0.0252991 (rank : 120)
Query Neighborhood Hits	554	Target Neighborhood Hits	1644	Shared Neighborhood Hits	281
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ANM2_HUMAN
NC score	0.169979 (rank : 151)	θ value	1.81305 (rank : 344)
Query Neighborhood Hits	554	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MISS_MOUSE
NC score	0.169590 (rank : 152)	θ value	4.03905 (rank : 447)
Query Neighborhood Hits	554	Target Neighborhood Hits	444	Shared Neighborhood Hits	175
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

BAT2_MOUSE
NC score	0.169529 (rank : 153)	θ value	0.00390308 (rank : 68)
Query Neighborhood Hits	554	Target Neighborhood Hits	947	Shared Neighborhood Hits	212
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

ATN1_HUMAN
NC score	0.166854 (rank : 154)	θ value	0.0330416 (rank : 127)
Query Neighborhood Hits	554	Target Neighborhood Hits	676	Shared Neighborhood Hits	131
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

GSCR1_HUMAN
NC score	0.166441 (rank : 155)	θ value	0.000786445 (rank : 50)
Query Neighborhood Hits	554	Target Neighborhood Hits	674	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

FA47B_HUMAN
NC score	0.166231 (rank : 156)	θ value	0.47712 (rank : 259)
Query Neighborhood Hits	554	Target Neighborhood Hits	431	Shared Neighborhood Hits	158
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

SRGP2_HUMAN
NC score	0.165919 (rank : 157)	θ value	2.36792 (rank : 392)
Query Neighborhood Hits	554	Target Neighborhood Hits	331	Shared Neighborhood Hits	145
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ARI1A_HUMAN
NC score	0.163404 (rank : 158)	θ value	0.125558 (rank : 191)
Query Neighborhood Hits	554	Target Neighborhood Hits	787	Shared Neighborhood Hits	191
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

ANM2_MOUSE
NC score	0.163140 (rank : 159)	θ value	1.81305 (rank : 345)
Query Neighborhood Hits	554	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RERE_MOUSE
NC score	0.162254 (rank : 160)	θ value	0.0113563 (rank : 96)
Query Neighborhood Hits	554	Target Neighborhood Hits	785	Shared Neighborhood Hits	155
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SPTA1_HUMAN
NC score	0.162253 (rank : 161)	θ value	0.00298849 (rank : 63)
Query Neighborhood Hits	554	Target Neighborhood Hits	748	Shared Neighborhood Hits	167
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

LCP2_HUMAN
NC score	0.161428 (rank : 162)	θ value	2.36792 (rank : 385)
Query Neighborhood Hits	554	Target Neighborhood Hits	531	Shared Neighborhood Hits	184
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BSN_MOUSE
NC score	0.158292 (rank : 163)	θ value	0.47712 (rank : 254)
Query Neighborhood Hits	554	Target Neighborhood Hits	2057	Shared Neighborhood Hits	292
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

SHLB1_MOUSE
NC score	0.157913 (rank : 164)	θ value	3.0926 (rank : 421)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SRGP1_HUMAN
NC score	0.156295 (rank : 165)	θ value	6.88961 (rank : 508)
Query Neighborhood Hits	554	Target Neighborhood Hits	390	Shared Neighborhood Hits	143
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RIMB1_HUMAN
NC score	0.155672 (rank : 166)	θ value	1.06291 (rank : 319)
Query Neighborhood Hits	554	Target Neighborhood Hits	1479	Shared Neighborhood Hits	219
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MAGE1_HUMAN
NC score	0.154330 (rank : 167)	θ value	0.279714 (rank : 229)
Query Neighborhood Hits	554	Target Neighborhood Hits	1389	Shared Neighborhood Hits	267
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

FNBP2_HUMAN
NC score	0.154162 (rank : 168)	θ value	4.03905 (rank : 442)
Query Neighborhood Hits	554	Target Neighborhood Hits	432	Shared Neighborhood Hits	161
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SPTA1_MOUSE
NC score	0.153479 (rank : 169)	θ value	0.21417 (rank : 218)
Query Neighborhood Hits	554	Target Neighborhood Hits	675	Shared Neighborhood Hits	155
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RERE_HUMAN
NC score	0.153088 (rank : 170)	θ value	0.00390308 (rank : 72)
Query Neighborhood Hits	554	Target Neighborhood Hits	779	Shared Neighborhood Hits	151
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SHLB1_HUMAN
NC score	0.152548 (rank : 171)	θ value	4.03905 (rank : 454)
Query Neighborhood Hits	554	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

TARSH_HUMAN
NC score	0.152257 (rank : 172)	θ value	3.0926 (rank : 423)
Query Neighborhood Hits	554	Target Neighborhood Hits	768	Shared Neighborhood Hits	201
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

MLL3_MOUSE
NC score	0.151709 (rank : 173)	θ value	0.365318 (rank : 243)
Query Neighborhood Hits	554	Target Neighborhood Hits	1399	Shared Neighborhood Hits	239
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MBD6_HUMAN
NC score	0.150952 (rank : 174)	θ value	0.00102713 (rank : 51)
Query Neighborhood Hits	554	Target Neighborhood Hits	349	Shared Neighborhood Hits	82
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

YLPM1_HUMAN
NC score	0.149675 (rank : 175)	θ value	0.00390308 (rank : 75)
Query Neighborhood Hits	554	Target Neighborhood Hits	670	Shared Neighborhood Hits	148
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

RAPH1_HUMAN
NC score	0.149128 (rank : 176)	θ value	0.00509761 (rank : 78)
Query Neighborhood Hits	554	Target Neighborhood Hits	593	Shared Neighborhood Hits	142
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RUSC2_HUMAN
NC score	0.147120 (rank : 177)	θ value	0.62314 (rank : 280)
Query Neighborhood Hits	554	Target Neighborhood Hits	205	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

PRP1_HUMAN
NC score	0.146699 (rank : 178)	θ value	0.0252991 (rank : 123)
Query Neighborhood Hits	554	Target Neighborhood Hits	385	Shared Neighborhood Hits	97
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PCLO_MOUSE
NC score	0.146478 (rank : 179)	θ value	0.0736092 (rank : 169)
Query Neighborhood Hits	554	Target Neighborhood Hits	2275	Shared Neighborhood Hits	317
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

GAK5_HUMAN
NC score	0.144966 (rank : 180)	θ value	0.0252991 (rank : 116)
Query Neighborhood Hits	554	Target Neighborhood Hits	429	Shared Neighborhood Hits	164
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

RGS3_HUMAN
NC score	0.144895 (rank : 181)	θ value	0.0961366 (rank : 188)
Query Neighborhood Hits	554	Target Neighborhood Hits	1375	Shared Neighborhood Hits	259
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ES8L1_HUMAN
NC score	0.144634 (rank : 182)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

GAK4_HUMAN
NC score	0.143730 (rank : 183)	θ value	0.0193708 (rank : 111)
Query Neighborhood Hits	554	Target Neighborhood Hits	415	Shared Neighborhood Hits	164
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.143588 (rank : 184)	θ value	0.0193708 (rank : 109)
Query Neighborhood Hits	554	Target Neighborhood Hits	409	Shared Neighborhood Hits	164
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
NC score	0.143128 (rank : 185)	θ value	0.0148317 (rank : 100)
Query Neighborhood Hits	554	Target Neighborhood Hits	406	Shared Neighborhood Hits	162
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PRB4S_HUMAN
NC score	0.141959 (rank : 186)	θ value	0.365318 (rank : 248)
Query Neighborhood Hits	554	Target Neighborhood Hits	330	Shared Neighborhood Hits	91
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SNX9_HUMAN
NC score	0.141881 (rank : 187)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	554	Target Neighborhood Hits	148	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

GAK6_HUMAN
NC score	0.141835 (rank : 188)	θ value	0.0252991 (rank : 117)
Query Neighborhood Hits	554	Target Neighborhood Hits	392	Shared Neighborhood Hits	160
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ES8L1_MOUSE
NC score	0.141672 (rank : 189)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	554	Target Neighborhood Hits	143	Shared Neighborhood Hits	90
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

PRR12_HUMAN
NC score	0.141626 (rank : 190)	θ value	0.21417 (rank : 217)
Query Neighborhood Hits	554	Target Neighborhood Hits	460	Shared Neighborhood Hits	112
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SHAN1_HUMAN
NC score	0.141535 (rank : 191)	θ value	0.00509761 (rank : 79)
Query Neighborhood Hits	554	Target Neighborhood Hits	1041	Shared Neighborhood Hits	218
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

WASL_MOUSE
NC score	0.139633 (rank : 192)	θ value	0.0148317 (rank : 104)
Query Neighborhood Hits	554	Target Neighborhood Hits	339	Shared Neighborhood Hits	89
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

TAF4_HUMAN
NC score	0.139144 (rank : 193)	θ value	0.0563607 (rank : 157)
Query Neighborhood Hits	554	Target Neighborhood Hits	687	Shared Neighborhood Hits	129
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

PCLO_HUMAN
NC score	0.138858 (rank : 194)	θ value	0.21417 (rank : 216)
Query Neighborhood Hits	554	Target Neighborhood Hits	2046	Shared Neighborhood Hits	276
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RUSC2_MOUSE
NC score	0.138472 (rank : 195)	θ value	1.38821 (rank : 335)
Query Neighborhood Hits	554	Target Neighborhood Hits	305	Shared Neighborhood Hits	114
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CBP_MOUSE
NC score	0.138438 (rank : 196)	θ value	0.813845 (rank : 289)
Query Neighborhood Hits	554	Target Neighborhood Hits	1051	Shared Neighborhood Hits	220
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

LPP_HUMAN
NC score	0.138223 (rank : 197)	θ value	6.88961 (rank : 494)
Query Neighborhood Hits	554	Target Neighborhood Hits	775	Shared Neighborhood Hits	240
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MLL2_HUMAN
NC score	0.138109 (rank : 198)	θ value	0.0252991 (rank : 119)
Query Neighborhood Hits	554	Target Neighborhood Hits	1788	Shared Neighborhood Hits	240
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ARI1B_HUMAN
NC score	0.137894 (rank : 199)	θ value	0.0113563 (rank : 93)
Query Neighborhood Hits	554	Target Neighborhood Hits	567	Shared Neighborhood Hits	151
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

SPN90_HUMAN
NC score	0.137300 (rank : 200)	θ value	4.03905 (rank : 457)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

GAK12_HUMAN
NC score	0.136882 (rank : 201)	θ value	0.0193708 (rank : 110)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	151
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

SAPS1_HUMAN
NC score	0.136679 (rank : 202)	θ value	0.0431538 (rank : 143)
Query Neighborhood Hits	554	Target Neighborhood Hits	704	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CPSF6_MOUSE
NC score	0.136296 (rank : 203)	θ value	0.163984 (rank : 203)
Query Neighborhood Hits	554	Target Neighborhood Hits	356	Shared Neighborhood Hits	94
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CPSF6_HUMAN
NC score	0.136217 (rank : 204)	θ value	0.163984 (rank : 202)
Query Neighborhood Hits	554	Target Neighborhood Hits	359	Shared Neighborhood Hits	94
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

SHAN2_MOUSE
NC score	0.135925 (rank : 205)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	554	Target Neighborhood Hits	446	Shared Neighborhood Hits	140
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SON_MOUSE
NC score	0.135003 (rank : 206)	θ value	0.163984 (rank : 208)
Query Neighborhood Hits	554	Target Neighborhood Hits	957	Shared Neighborhood Hits	188
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

RIMB1_MOUSE
NC score	0.134730 (rank : 207)	θ value	0.62314 (rank : 279)
Query Neighborhood Hits	554	Target Neighborhood Hits	1376	Shared Neighborhood Hits	208
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

WASL_HUMAN
NC score	0.134469 (rank : 208)	θ value	0.0148317 (rank : 103)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	90
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

MDC1_HUMAN
NC score	0.133298 (rank : 209)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	554	Target Neighborhood Hits	1446	Shared Neighborhood Hits	217
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

BCL9_MOUSE
NC score	0.133190 (rank : 210)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	554	Target Neighborhood Hits	770	Shared Neighborhood Hits	208
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

K1802_MOUSE
NC score	0.132181 (rank : 211)	θ value	0.365318 (rank : 240)
Query Neighborhood Hits	554	Target Neighborhood Hits	1596	Shared Neighborhood Hits	250
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CEL_HUMAN
NC score	0.132112 (rank : 212)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	554	Target Neighborhood Hits	896	Shared Neighborhood Hits	228
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SNX9_MOUSE
NC score	0.130776 (rank : 213)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	554	Target Neighborhood Hits	141	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SF01_HUMAN
NC score	0.130634 (rank : 214)	θ value	0.0193708 (rank : 113)
Query Neighborhood Hits	554	Target Neighborhood Hits	287	Shared Neighborhood Hits	88
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SC24C_HUMAN
NC score	0.130630 (rank : 215)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	554	Target Neighborhood Hits	662	Shared Neighborhood Hits	201
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

MDC1_MOUSE
NC score	0.130499 (rank : 216)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	554	Target Neighborhood Hits	998	Shared Neighborhood Hits	200
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

R3HD2_MOUSE
NC score	0.130118 (rank : 217)	θ value	3.0926 (rank : 415)
Query Neighborhood Hits	554	Target Neighborhood Hits	397	Shared Neighborhood Hits	135
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

CBP_HUMAN
NC score	0.130087 (rank : 218)	θ value	0.813845 (rank : 288)
Query Neighborhood Hits	554	Target Neighborhood Hits	941	Shared Neighborhood Hits	200
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

M3KL4_HUMAN
NC score	0.129321 (rank : 219)	θ value	3.19293e-05 (rank : 24)
Query Neighborhood Hits	554	Target Neighborhood Hits	1087	Shared Neighborhood Hits	174
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

GAK10_HUMAN
NC score	0.128832 (rank : 220)	θ value	0.125558 (rank : 195)
Query Neighborhood Hits	554	Target Neighborhood Hits	289	Shared Neighborhood Hits	122
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

EP300_HUMAN
NC score	0.127140 (rank : 221)	θ value	0.21417 (rank : 213)
Query Neighborhood Hits	554	Target Neighborhood Hits	821	Shared Neighborhood Hits	171
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

SSBP4_HUMAN
NC score	0.126814 (rank : 222)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	554	Target Neighborhood Hits	753	Shared Neighborhood Hits	206
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

YLPM1_MOUSE
NC score	0.126789 (rank : 223)	θ value	0.813845 (rank : 304)
Query Neighborhood Hits	554	Target Neighborhood Hits	505	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

PHC2_HUMAN
NC score	0.126262 (rank : 224)	θ value	0.00665767 (rank : 83)
Query Neighborhood Hits	554	Target Neighborhood Hits	388	Shared Neighborhood Hits	137
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

MKL1_MOUSE
NC score	0.126132 (rank : 225)	θ value	0.163984 (rank : 206)
Query Neighborhood Hits	554	Target Neighborhood Hits	667	Shared Neighborhood Hits	180
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

M3K11_HUMAN
NC score	0.125297 (rank : 226)	θ value	0.000270298 (rank : 37)
Query Neighborhood Hits	554	Target Neighborhood Hits	1136	Shared Neighborhood Hits	210
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

CD2_HUMAN
NC score	0.124598 (rank : 227)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	554	Target Neighborhood Hits	504	Shared Neighborhood Hits	169
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CK024_HUMAN
NC score	0.124492 (rank : 228)	θ value	2.36792 (rank : 375)
Query Neighborhood Hits	554	Target Neighborhood Hits	408	Shared Neighborhood Hits	135
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

MUC7_HUMAN
NC score	0.122907 (rank : 229)	θ value	0.365318 (rank : 244)
Query Neighborhood Hits	554	Target Neighborhood Hits	538	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MCF2L_MOUSE
NC score	0.122416 (rank : 230)	θ value	0.125558 (rank : 197)
Query Neighborhood Hits	554	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ZIMP7_MOUSE
NC score	0.121518 (rank : 231)	θ value	0.0148317 (rank : 105)
Query Neighborhood Hits	554	Target Neighborhood Hits	566	Shared Neighborhood Hits	167
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

FA47A_HUMAN
NC score	0.121318 (rank : 232)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	554	Target Neighborhood Hits	451	Shared Neighborhood Hits	138
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

SHLB2_MOUSE
NC score	0.121189 (rank : 233)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	554	Target Neighborhood Hits	88	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

WIRE_HUMAN
NC score	0.120331 (rank : 234)	θ value	2.36792 (rank : 393)
Query Neighborhood Hits	554	Target Neighborhood Hits	329	Shared Neighborhood Hits	89
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

SHLB2_HUMAN
NC score	0.120071 (rank : 235)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	554	Target Neighborhood Hits	86	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

S23IP_MOUSE
NC score	0.120065 (rank : 236)	θ value	0.125558 (rank : 200)
Query Neighborhood Hits	554	Target Neighborhood Hits	363	Shared Neighborhood Hits	125
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

PELP1_MOUSE
NC score	0.119579 (rank : 237)	θ value	1.06291 (rank : 317)
Query Neighborhood Hits	554	Target Neighborhood Hits	709	Shared Neighborhood Hits	153
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

SF01_MOUSE
NC score	0.119243 (rank : 238)	θ value	0.0431538 (rank : 144)
Query Neighborhood Hits	554	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SFPQ_MOUSE
NC score	0.118487 (rank : 239)	θ value	0.0193708 (rank : 114)
Query Neighborhood Hits	554	Target Neighborhood Hits	958	Shared Neighborhood Hits	131
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

WASF2_MOUSE
NC score	0.118302 (rank : 240)	θ value	1.06291 (rank : 324)
Query Neighborhood Hits	554	Target Neighborhood Hits	315	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

SPN90_MOUSE
NC score	0.118029 (rank : 241)	θ value	6.88961 (rank : 507)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RNC_HUMAN
NC score	0.116510 (rank : 242)	θ value	0.0113563 (rank : 97)
Query Neighborhood Hits	554	Target Neighborhood Hits	176	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

CIC_HUMAN
NC score	0.115759 (rank : 243)	θ value	4.03905 (rank : 433)
Query Neighborhood Hits	554	Target Neighborhood Hits	992	Shared Neighborhood Hits	219
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CN032_HUMAN
NC score	0.115295 (rank : 244)	θ value	0.365318 (rank : 236)
Query Neighborhood Hits	554	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

GAK1_HUMAN
NC score	0.114998 (rank : 245)	θ value	0.813845 (rank : 291)
Query Neighborhood Hits	554	Target Neighborhood Hits	268	Shared Neighborhood Hits	114
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

SFPQ_HUMAN
NC score	0.114845 (rank : 246)	θ value	0.00869519 (rank : 88)
Query Neighborhood Hits	554	Target Neighborhood Hits	986	Shared Neighborhood Hits	137
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

M3K9_HUMAN
NC score	0.114773 (rank : 247)	θ value	0.000158464 (rank : 29)
Query Neighborhood Hits	554	Target Neighborhood Hits	1123	Shared Neighborhood Hits	194
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRRM1_MOUSE
NC score	0.114315 (rank : 248)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	554	Target Neighborhood Hits	966	Shared Neighborhood Hits	177
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

MUCDL_HUMAN
NC score	0.113126 (rank : 249)	θ value	1.06291 (rank : 315)
Query Neighborhood Hits	554	Target Neighborhood Hits	777	Shared Neighborhood Hits	181
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

WIRE_MOUSE
NC score	0.112693 (rank : 250)	θ value	4.03905 (rank : 459)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	88
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

CN032_MOUSE
NC score	0.112444 (rank : 251)	θ value	2.36792 (rank : 376)
Query Neighborhood Hits	554	Target Neighborhood Hits	233	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

FMN2_HUMAN
NC score	0.112400 (rank : 252)	θ value	0.125558 (rank : 194)
Query Neighborhood Hits	554	Target Neighborhood Hits	484	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

ZIM10_HUMAN
NC score	0.112226 (rank : 253)	θ value	3.0926 (rank : 429)
Query Neighborhood Hits	554	Target Neighborhood Hits	577	Shared Neighborhood Hits	181
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ATX2L_HUMAN
NC score	0.111870 (rank : 254)	θ value	0.21417 (rank : 211)
Query Neighborhood Hits	554	Target Neighborhood Hits	443	Shared Neighborhood Hits	130
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

WASF2_HUMAN
NC score	0.111403 (rank : 255)	θ value	1.81305 (rank : 371)
Query Neighborhood Hits	554	Target Neighborhood Hits	280	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

ENAH_MOUSE
NC score	0.110999 (rank : 256)	θ value	0.163984 (rank : 205)
Query Neighborhood Hits	554	Target Neighborhood Hits	919	Shared Neighborhood Hits	134
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

BSN_HUMAN
NC score	0.110724 (rank : 257)	θ value	4.03905 (rank : 431)
Query Neighborhood Hits	554	Target Neighborhood Hits	1537	Shared Neighborhood Hits	208
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

FMN1A_MOUSE
NC score	0.110643 (rank : 258)	θ value	0.0431538 (rank : 137)
Query Neighborhood Hits	554	Target Neighborhood Hits	423	Shared Neighborhood Hits	96
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

CCNK_MOUSE
NC score	0.110282 (rank : 259)	θ value	0.0330416 (rank : 128)
Query Neighborhood Hits	554	Target Neighborhood Hits	350	Shared Neighborhood Hits	93
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

ATX2L_MOUSE
NC score	0.110136 (rank : 260)	θ value	0.0736092 (rank : 161)
Query Neighborhood Hits	554	Target Neighborhood Hits	401	Shared Neighborhood Hits	116
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

BRD4_HUMAN
NC score	0.110092 (rank : 261)	θ value	0.0193708 (rank : 107)
Query Neighborhood Hits	554	Target Neighborhood Hits	851	Shared Neighborhood Hits	138
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

OBF1_HUMAN
NC score	0.109552 (rank : 262)	θ value	0.47712 (rank : 263)
Query Neighborhood Hits	554	Target Neighborhood Hits	203	Shared Neighborhood Hits	103
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

SYN1_HUMAN
NC score	0.109502 (rank : 263)	θ value	0.0431538 (rank : 148)
Query Neighborhood Hits	554	Target Neighborhood Hits	419	Shared Neighborhood Hits	103
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

AMPH_HUMAN
NC score	0.109399 (rank : 264)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	554	Target Neighborhood Hits	455	Shared Neighborhood Hits	132
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

FMN1B_MOUSE
NC score	0.108808 (rank : 265)	θ value	0.0431538 (rank : 138)
Query Neighborhood Hits	554	Target Neighborhood Hits	447	Shared Neighborhood Hits	94
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

BRD4_MOUSE
NC score	0.107613 (rank : 266)	θ value	0.0148317 (rank : 98)
Query Neighborhood Hits	554	Target Neighborhood Hits	845	Shared Neighborhood Hits	129
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

WASF4_HUMAN
NC score	0.107548 (rank : 267)	θ value	3.0926 (rank : 427)
Query Neighborhood Hits	554	Target Neighborhood Hits	282	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

GAK8_HUMAN
NC score	0.105099 (rank : 268)	θ value	0.0736092 (rank : 164)
Query Neighborhood Hits	554	Target Neighborhood Hits	145	Shared Neighborhood Hits	68
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK7_HUMAN
NC score	0.104754 (rank : 269)	θ value	0.0736092 (rank : 163)
Query Neighborhood Hits	554	Target Neighborhood Hits	90	Shared Neighborhood Hits	42
SwissProt Accessions	Q96PI4, Q9QC08	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q23.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K18 Gag protein) (HERV-K110 Gag protein) (HERV-K(C1a) Gag protein) [Contains: Matrix protein].

NGEF_MOUSE
NC score	0.104634 (rank : 270)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PRB3_HUMAN
NC score	0.104170 (rank : 271)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	554	Target Neighborhood Hits	318	Shared Neighborhood Hits	77
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

MNT_HUMAN
NC score	0.103933 (rank : 272)	θ value	1.81305 (rank : 358)
Query Neighborhood Hits	554	Target Neighborhood Hits	496	Shared Neighborhood Hits	128
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

CSKI1_MOUSE
NC score	0.103717 (rank : 273)	θ value	0.0193708 (rank : 108)
Query Neighborhood Hits	554	Target Neighborhood Hits	1031	Shared Neighborhood Hits	231
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

WASF1_MOUSE
NC score	0.103664 (rank : 274)	θ value	0.813845 (rank : 301)
Query Neighborhood Hits	554	Target Neighborhood Hits	261	Shared Neighborhood Hits	79
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

PSL1_HUMAN
NC score	0.102987 (rank : 275)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	554	Target Neighborhood Hits	650	Shared Neighborhood Hits	194
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

K0310_HUMAN
NC score	0.102755 (rank : 276)	θ value	0.279714 (rank : 228)
Query Neighborhood Hits	554	Target Neighborhood Hits	420	Shared Neighborhood Hits	114
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

BIN1_HUMAN
NC score	0.102644 (rank : 277)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	554	Target Neighborhood Hits	335	Shared Neighborhood Hits	123
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SPTA3_MOUSE
NC score	0.102501 (rank : 278)	θ value	0.21417 (rank : 219)
Query Neighborhood Hits	554	Target Neighborhood Hits	74	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

HGS_MOUSE
NC score	0.102003 (rank : 279)	θ value	0.0961366 (rank : 179)
Query Neighborhood Hits	554	Target Neighborhood Hits	589	Shared Neighborhood Hits	125
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

WASF3_HUMAN
NC score	0.101709 (rank : 280)	θ value	0.21417 (rank : 223)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

FMN2_MOUSE
NC score	0.101632 (rank : 281)	θ value	0.21417 (rank : 215)
Query Neighborhood Hits	554	Target Neighborhood Hits	349	Shared Neighborhood Hits	103
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

ARHG5_HUMAN
NC score	0.101412 (rank : 282)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	554	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

M3K10_HUMAN
NC score	0.100519 (rank : 283)	θ value	0.00298849 (rank : 61)
Query Neighborhood Hits	554	Target Neighborhood Hits	1071	Shared Neighborhood Hits	163
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

WASF1_HUMAN
NC score	0.099832 (rank : 284)	θ value	1.81305 (rank : 370)
Query Neighborhood Hits	554	Target Neighborhood Hits	260	Shared Neighborhood Hits	79
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

NGEF_HUMAN
NC score	0.099809 (rank : 285)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	554	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FYN_MOUSE
NC score	0.099725 (rank : 286)	θ value	1.38821 (rank : 332)
Query Neighborhood Hits	554	Target Neighborhood Hits	1073	Shared Neighborhood Hits	175
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SLAP2_HUMAN
NC score	0.099685 (rank : 287)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	554	Target Neighborhood Hits	139	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

YES_MOUSE
NC score	0.099552 (rank : 288)	θ value	0.813845 (rank : 303)
Query Neighborhood Hits	554	Target Neighborhood Hits	1052	Shared Neighborhood Hits	171
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SYN1_MOUSE
NC score	0.099455 (rank : 289)	θ value	1.38821 (rank : 339)
Query Neighborhood Hits	554	Target Neighborhood Hits	363	Shared Neighborhood Hits	92
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

STS2_HUMAN
NC score	0.099374 (rank : 290)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	72
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SRC_HUMAN
NC score	0.099306 (rank : 291)	θ value	0.813845 (rank : 298)
Query Neighborhood Hits	554	Target Neighborhood Hits	1058	Shared Neighborhood Hits	179
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SELPL_MOUSE
NC score	0.099302 (rank : 292)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	554	Target Neighborhood Hits	588	Shared Neighborhood Hits	149
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

WBP11_HUMAN
NC score	0.099191 (rank : 293)	θ value	6.88961 (rank : 512)
Query Neighborhood Hits	554	Target Neighborhood Hits	354	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

SPR1B_MOUSE
NC score	0.099145 (rank : 294)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	554	Target Neighborhood Hits	395	Shared Neighborhood Hits	135
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

YES_HUMAN
NC score	0.098929 (rank : 295)	θ value	0.813845 (rank : 302)
Query Neighborhood Hits	554	Target Neighborhood Hits	1059	Shared Neighborhood Hits	171
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_HUMAN
NC score	0.098495 (rank : 296)	θ value	0.62314 (rank : 273)
Query Neighborhood Hits	554	Target Neighborhood Hits	1067	Shared Neighborhood Hits	169
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SOX13_HUMAN
NC score	0.098397 (rank : 297)	θ value	0.0736092 (rank : 174)
Query Neighborhood Hits	554	Target Neighborhood Hits	464	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

BAG3_MOUSE
NC score	0.098012 (rank : 298)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	554	Target Neighborhood Hits	513	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

TXND2_HUMAN
NC score	0.098005 (rank : 299)	θ value	0.62314 (rank : 282)
Query Neighborhood Hits	554	Target Neighborhood Hits	793	Shared Neighborhood Hits	111
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

FYN_HUMAN
NC score	0.097781 (rank : 300)	θ value	1.38821 (rank : 331)
Query Neighborhood Hits	554	Target Neighborhood Hits	1078	Shared Neighborhood Hits	175
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

CO039_MOUSE
NC score	0.097675 (rank : 301)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	554	Target Neighborhood Hits	445	Shared Neighborhood Hits	140
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CSKI1_HUMAN
NC score	0.097176 (rank : 302)	θ value	0.0563607 (rank : 150)
Query Neighborhood Hits	554	Target Neighborhood Hits	997	Shared Neighborhood Hits	201
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

HGS_HUMAN
NC score	0.097019 (rank : 303)	θ value	0.0193708 (rank : 112)
Query Neighborhood Hits	554	Target Neighborhood Hits	517	Shared Neighborhood Hits	103
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

PI5PA_HUMAN
NC score	0.096946 (rank : 304)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	554	Target Neighborhood Hits	749	Shared Neighborhood Hits	198
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SLAP2_MOUSE
NC score	0.096861 (rank : 305)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	554	Target Neighborhood Hits	136	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

CRSP2_HUMAN
NC score	0.096453 (rank : 306)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	554	Target Neighborhood Hits	380	Shared Neighborhood Hits	127
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

TPO_MOUSE
NC score	0.096237 (rank : 307)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	103
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

GAK3_HUMAN
NC score	0.096167 (rank : 308)	θ value	8.99809 (rank : 530)
Query Neighborhood Hits	554	Target Neighborhood Hits	182	Shared Neighborhood Hits	73
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MTSS1_MOUSE
NC score	0.095497 (rank : 309)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	554	Target Neighborhood Hits	592	Shared Neighborhood Hits	153
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

FGR_MOUSE
NC score	0.094256 (rank : 310)	θ value	3.0926 (rank : 400)
Query Neighborhood Hits	554	Target Neighborhood Hits	1069	Shared Neighborhood Hits	171
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MUC2_HUMAN
NC score	0.094146 (rank : 311)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	554	Target Neighborhood Hits	906	Shared Neighborhood Hits	111
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

FMNL_HUMAN
NC score	0.093970 (rank : 312)	θ value	3.0926 (rank : 402)
Query Neighborhood Hits	554	Target Neighborhood Hits	529	Shared Neighborhood Hits	106
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

AMPH_MOUSE
NC score	0.093913 (rank : 313)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	554	Target Neighborhood Hits	291	Shared Neighborhood Hits	92
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BTK_HUMAN
NC score	0.093861 (rank : 314)	θ value	0.62314 (rank : 270)
Query Neighborhood Hits	554	Target Neighborhood Hits	1026	Shared Neighborhood Hits	173
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CRTC1_HUMAN
NC score	0.093385 (rank : 315)	θ value	1.81305 (rank : 349)
Query Neighborhood Hits	554	Target Neighborhood Hits	319	Shared Neighborhood Hits	108
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

HCK_HUMAN
NC score	0.093180 (rank : 316)	θ value	0.0431538 (rank : 139)
Query Neighborhood Hits	554	Target Neighborhood Hits	1035	Shared Neighborhood Hits	170
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MINT_MOUSE
NC score	0.092363 (rank : 317)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	554	Target Neighborhood Hits	1514	Shared Neighborhood Hits	223
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

WBP11_MOUSE
NC score	0.090810 (rank : 318)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	554	Target Neighborhood Hits	362	Shared Neighborhood Hits	79
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

MLL4_HUMAN
NC score	0.090773 (rank : 319)	θ value	1.81305 (rank : 357)
Query Neighborhood Hits	554	Target Neighborhood Hits	722	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

CECR2_HUMAN
NC score	0.090763 (rank : 320)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	554	Target Neighborhood Hits	543	Shared Neighborhood Hits	146
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

GGN_MOUSE
NC score	0.090360 (rank : 321)	θ value	3.0926 (rank : 403)
Query Neighborhood Hits	554	Target Neighborhood Hits	311	Shared Neighborhood Hits	73
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

P85A_MOUSE
NC score	0.089967 (rank : 322)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	554	Target Neighborhood Hits	435	Shared Neighborhood Hits	107
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNPC4_HUMAN
NC score	0.089848 (rank : 323)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	554	Target Neighborhood Hits	589	Shared Neighborhood Hits	162
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

DIDO1_HUMAN
NC score	0.089508 (rank : 324)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	554	Target Neighborhood Hits	960	Shared Neighborhood Hits	166
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

HCK_MOUSE
NC score	0.089320 (rank : 325)	θ value	0.279714 (rank : 227)
Query Neighborhood Hits	554	Target Neighborhood Hits	1029	Shared Neighborhood Hits	168
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

RTP3_MOUSE
NC score	0.089223 (rank : 326)	θ value	1.81305 (rank : 366)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	111
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SRRM2_MOUSE
NC score	0.089197 (rank : 327)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	554	Target Neighborhood Hits	1470	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CIP4_HUMAN
NC score	0.089135 (rank : 328)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	75
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SRRM1_HUMAN
NC score	0.088760 (rank : 329)	θ value	4.03905 (rank : 458)
Query Neighborhood Hits	554	Target Neighborhood Hits	690	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

PKHG1_HUMAN
NC score	0.088601 (rank : 330)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	554	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

TAB3_MOUSE
NC score	0.088517 (rank : 331)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	554	Target Neighborhood Hits	273	Shared Neighborhood Hits	87
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

BLNK_MOUSE
NC score	0.088347 (rank : 332)	θ value	3.0926 (rank : 396)
Query Neighborhood Hits	554	Target Neighborhood Hits	296	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

WASF3_MOUSE
NC score	0.088324 (rank : 333)	θ value	0.21417 (rank : 224)
Query Neighborhood Hits	554	Target Neighborhood Hits	188	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

ALEX_HUMAN
NC score	0.088314 (rank : 334)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	554	Target Neighborhood Hits	361	Shared Neighborhood Hits	106
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

SC24A_MOUSE
NC score	0.087953 (rank : 335)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	554	Target Neighborhood Hits	394	Shared Neighborhood Hits	156
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SLAP1_HUMAN
NC score	0.087013 (rank : 336)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	554	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BIN1_MOUSE
NC score	0.086591 (rank : 337)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	554	Target Neighborhood Hits	283	Shared Neighborhood Hits	102
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BTK_MOUSE
NC score	0.086512 (rank : 338)	θ value	1.81305 (rank : 348)
Query Neighborhood Hits	554	Target Neighborhood Hits	1017	Shared Neighborhood Hits	165
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

DOCK1_HUMAN
NC score	0.086494 (rank : 339)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	554	Target Neighborhood Hits	191	Shared Neighborhood Hits	106
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

NFRKB_MOUSE
NC score	0.086432 (rank : 340)	θ value	1.38821 (rank : 333)
Query Neighborhood Hits	554	Target Neighborhood Hits	393	Shared Neighborhood Hits	100
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

GAK18_HUMAN
NC score	0.086020 (rank : 341)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	554	Target Neighborhood Hits	116	Shared Neighborhood Hits	42
SwissProt Accessions	P62690	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.23 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

P85A_HUMAN
NC score	0.085724 (rank : 342)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	554	Target Neighborhood Hits	479	Shared Neighborhood Hits	104
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SRC_MOUSE
NC score	0.085526 (rank : 343)	θ value	2.36792 (rank : 391)
Query Neighborhood Hits	554	Target Neighborhood Hits	1033	Shared Neighborhood Hits	168
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

K1802_HUMAN
NC score	0.085293 (rank : 344)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	554	Target Neighborhood Hits	1378	Shared Neighborhood Hits	206
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

ATX2_MOUSE
NC score	0.085254 (rank : 345)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	554	Target Neighborhood Hits	445	Shared Neighborhood Hits	127
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

SOX13_MOUSE
NC score	0.085082 (rank : 346)	θ value	0.47712 (rank : 267)
Query Neighborhood Hits	554	Target Neighborhood Hits	495	Shared Neighborhood Hits	128
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SLAP1_MOUSE
NC score	0.084761 (rank : 347)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	554	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

ARHGG_MOUSE
NC score	0.084714 (rank : 348)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	53
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

GA2L2_MOUSE
NC score	0.084611 (rank : 349)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	554	Target Neighborhood Hits	395	Shared Neighborhood Hits	140
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

PREX1_HUMAN
NC score	0.084409 (rank : 350)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ZN645_HUMAN
NC score	0.084352 (rank : 351)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	554	Target Neighborhood Hits	265	Shared Neighborhood Hits	97
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

NUMBL_HUMAN
NC score	0.084026 (rank : 352)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	554	Target Neighborhood Hits	394	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

FRK_HUMAN
NC score	0.083333 (rank : 353)	θ value	1.06291 (rank : 311)
Query Neighborhood Hits	554	Target Neighborhood Hits	1058	Shared Neighborhood Hits	173
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GPS2_HUMAN
NC score	0.083146 (rank : 354)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	554	Target Neighborhood Hits	459	Shared Neighborhood Hits	98
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

TIAM1_HUMAN
NC score	0.082956 (rank : 355)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

IF4G1_MOUSE
NC score	0.082563 (rank : 356)	θ value	0.365318 (rank : 239)
Query Neighborhood Hits	554	Target Neighborhood Hits	534	Shared Neighborhood Hits	140
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

TIAM1_MOUSE
NC score	0.082126 (rank : 357)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	554	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

LYN_HUMAN
NC score	0.082053 (rank : 358)	θ value	0.0961366 (rank : 181)
Query Neighborhood Hits	554	Target Neighborhood Hits	1022	Shared Neighborhood Hits	157
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

T22D4_HUMAN
NC score	0.081980 (rank : 359)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	554	Target Neighborhood Hits	403	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TULP4_HUMAN
NC score	0.081832 (rank : 360)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	554	Target Neighborhood Hits	426	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

PCQAP_HUMAN
NC score	0.081831 (rank : 361)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	554	Target Neighborhood Hits	549	Shared Neighborhood Hits	97
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

CN155_HUMAN
NC score	0.081533 (rank : 362)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	554	Target Neighborhood Hits	385	Shared Neighborhood Hits	74
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

LYN_MOUSE
NC score	0.081375 (rank : 363)	θ value	0.125558 (rank : 196)
Query Neighborhood Hits	554	Target Neighborhood Hits	1023	Shared Neighborhood Hits	158
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CS016_HUMAN
NC score	0.081373 (rank : 364)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	554	Target Neighborhood Hits	310	Shared Neighborhood Hits	78
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

PTN23_MOUSE
NC score	0.081045 (rank : 365)	θ value	0.000602161 (rank : 49)
Query Neighborhood Hits	554	Target Neighborhood Hits	726	Shared Neighborhood Hits	140
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

DOK1_HUMAN
NC score	0.080864 (rank : 366)	θ value	0.00228821 (rank : 59)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

SLY_MOUSE
NC score	0.080662 (rank : 367)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

FGD1_HUMAN
NC score	0.080493 (rank : 368)	θ value	1.06291 (rank : 310)
Query Neighborhood Hits	554	Target Neighborhood Hits	367	Shared Neighborhood Hits	90
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SET1A_HUMAN
NC score	0.080472 (rank : 369)	θ value	1.81305 (rank : 367)
Query Neighborhood Hits	554	Target Neighborhood Hits	690	Shared Neighborhood Hits	99
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

CJ078_MOUSE
NC score	0.080121 (rank : 370)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	554	Target Neighborhood Hits	559	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

TARA_HUMAN
NC score	0.079965 (rank : 371)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	554	Target Neighborhood Hits	1626	Shared Neighborhood Hits	203
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ARHG3_HUMAN
NC score	0.079137 (rank : 372)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	554	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

WASP_HUMAN
NC score	0.078839 (rank : 373)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	554	Target Neighborhood Hits	195	Shared Neighborhood Hits	63
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

ARHG3_MOUSE
NC score	0.078771 (rank : 374)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

PRR13_MOUSE
NC score	0.078682 (rank : 375)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	554	Target Neighborhood Hits	54	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CQJ5, Q3U3U4	Gene names	Prr13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

PRR13_HUMAN
NC score	0.078649 (rank : 376)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	554	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

WASP_MOUSE
NC score	0.078476 (rank : 377)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	554	Target Neighborhood Hits	223	Shared Neighborhood Hits	62
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

TROAP_HUMAN
NC score	0.078031 (rank : 378)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

R3HD1_HUMAN
NC score	0.077778 (rank : 379)	θ value	0.47712 (rank : 265)
Query Neighborhood Hits	554	Target Neighborhood Hits	203	Shared Neighborhood Hits	63
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

STS1_HUMAN
NC score	0.077269 (rank : 380)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	554	Target Neighborhood Hits	106	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.077251 (rank : 381)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	554	Target Neighborhood Hits	104	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BLK_HUMAN
NC score	0.077110 (rank : 382)	θ value	0.365318 (rank : 234)
Query Neighborhood Hits	554	Target Neighborhood Hits	994	Shared Neighborhood Hits	142
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MCF2_HUMAN
NC score	0.077008 (rank : 383)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	554	Target Neighborhood Hits	166	Shared Neighborhood Hits	26
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ZN385_HUMAN
NC score	0.076855 (rank : 384)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	554	Target Neighborhood Hits	614	Shared Neighborhood Hits	143
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

JIP1_HUMAN
NC score	0.076778 (rank : 385)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	554	Target Neighborhood Hits	271	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MNT_MOUSE
NC score	0.076749 (rank : 386)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	554	Target Neighborhood Hits	432	Shared Neighborhood Hits	87
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

CIC_MOUSE
NC score	0.076241 (rank : 387)	θ value	8.99809 (rank : 523)
Query Neighborhood Hits	554	Target Neighborhood Hits	742	Shared Neighborhood Hits	162
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

JIP1_MOUSE
NC score	0.076170 (rank : 388)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	554	Target Neighborhood Hits	259	Shared Neighborhood Hits	107
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARHG8_MOUSE
NC score	0.075853 (rank : 389)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	554	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ENAM_MOUSE
NC score	0.075796 (rank : 390)	θ value	1.06291 (rank : 307)
Query Neighborhood Hits	554	Target Neighborhood Hits	229	Shared Neighborhood Hits	62
SwissProt Accessions	O55196	Gene names	Enam
Domain Architecture	No domain graphic available
Description	Enamelin precursor.

NFH_MOUSE
NC score	0.075767 (rank : 391)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	554	Target Neighborhood Hits	2247	Shared Neighborhood Hits	232
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

WBS14_HUMAN
NC score	0.075573 (rank : 392)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	554	Target Neighborhood Hits	273	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

LR37A_HUMAN
NC score	0.075541 (rank : 393)	θ value	5.27518 (rank : 470)
Query Neighborhood Hits	554	Target Neighborhood Hits	720	Shared Neighborhood Hits	135
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

GAK17_HUMAN
NC score	0.075491 (rank : 394)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	554	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	P62689	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_11q22.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein].

GAK9_HUMAN
NC score	0.075415 (rank : 395)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	554	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKH8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q13.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K104 Gag protein) [Contains: Matrix protein].

GAK15_HUMAN
NC score	0.075029 (rank : 396)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	554	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	P62688	Gene names	ERVK4
Domain Architecture	No domain graphic available
Description	HERV-K_3q21.2 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(I) Gag protein).

CIZ1_HUMAN
NC score	0.074828 (rank : 397)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	554	Target Neighborhood Hits	359	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

P85B_HUMAN
NC score	0.074735 (rank : 398)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	554	Target Neighborhood Hits	543	Shared Neighborhood Hits	91
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DIAP1_HUMAN
NC score	0.074311 (rank : 399)	θ value	0.125558 (rank : 192)
Query Neighborhood Hits	554	Target Neighborhood Hits	784	Shared Neighborhood Hits	94
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

MYST3_HUMAN
NC score	0.074286 (rank : 400)	θ value	0.0431538 (rank : 140)
Query Neighborhood Hits	554	Target Neighborhood Hits	772	Shared Neighborhood Hits	88
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

WBP2_HUMAN
NC score	0.074231 (rank : 401)	θ value	0.62314 (rank : 284)
Query Neighborhood Hits	554	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q969T9, O95638	Gene names	WBP2
Domain Architecture
Description	WW domain-binding protein 2 (WBP-2).

PDC6I_HUMAN
NC score	0.074074 (rank : 402)	θ value	8.99809 (rank : 538)
Query Neighborhood Hits	554	Target Neighborhood Hits	278	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

S23IP_HUMAN
NC score	0.073941 (rank : 403)	θ value	0.0736092 (rank : 171)
Query Neighborhood Hits	554	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

OGFR_MOUSE
NC score	0.073917 (rank : 404)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	554	Target Neighborhood Hits	584	Shared Neighborhood Hits	104
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PTK6_HUMAN
NC score	0.073828 (rank : 405)	θ value	0.47712 (rank : 264)
Query Neighborhood Hits	554	Target Neighborhood Hits	1020	Shared Neighborhood Hits	156
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

FYB_HUMAN
NC score	0.073690 (rank : 406)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	554	Target Neighborhood Hits	379	Shared Neighborhood Hits	95
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

ZIM10_MOUSE
NC score	0.073565 (rank : 407)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	554	Target Neighborhood Hits	430	Shared Neighborhood Hits	129
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ARHGG_HUMAN
NC score	0.073218 (rank : 408)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	554	Target Neighborhood Hits	129	Shared Neighborhood Hits	42
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MILK1_MOUSE
NC score	0.072983 (rank : 409)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	554	Target Neighborhood Hits	788	Shared Neighborhood Hits	180
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

FMNL_MOUSE
NC score	0.072949 (rank : 410)	θ value	1.81305 (rank : 351)
Query Neighborhood Hits	554	Target Neighborhood Hits	428	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

RASA1_HUMAN
NC score	0.072741 (rank : 411)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	67
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

BAZ2A_MOUSE
NC score	0.072736 (rank : 412)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	554	Target Neighborhood Hits	744	Shared Neighborhood Hits	158
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

WBS14_MOUSE
NC score	0.072733 (rank : 413)	θ value	0.00869519 (rank : 92)
Query Neighborhood Hits	554	Target Neighborhood Hits	171	Shared Neighborhood Hits	42
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

K1688_MOUSE
NC score	0.072710 (rank : 414)	θ value	0.0961366 (rank : 180)
Query Neighborhood Hits	554	Target Neighborhood Hits	188	Shared Neighborhood Hits	56
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

PTK6_MOUSE
NC score	0.072634 (rank : 415)	θ value	3.0926 (rank : 414)
Query Neighborhood Hits	554	Target Neighborhood Hits	1026	Shared Neighborhood Hits	152
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

GAK19_HUMAN
NC score	0.072611 (rank : 416)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	554	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	P62691	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_4p16.1 provirus ancestral Gag polyprotein (Gag polyprotein).

TRI66_HUMAN
NC score	0.072519 (rank : 417)	θ value	0.21417 (rank : 222)
Query Neighborhood Hits	554	Target Neighborhood Hits	479	Shared Neighborhood Hits	90
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ARHG8_HUMAN
NC score	0.072483 (rank : 418)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

HRX_HUMAN
NC score	0.072459 (rank : 419)	θ value	0.365318 (rank : 238)
Query Neighborhood Hits	554	Target Neighborhood Hits	825	Shared Neighborhood Hits	94
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

CSKI2_MOUSE
NC score	0.072423 (rank : 420)	θ value	1.81305 (rank : 350)
Query Neighborhood Hits	554	Target Neighborhood Hits	812	Shared Neighborhood Hits	152
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

SPR1A_MOUSE
NC score	0.072340 (rank : 421)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	554	Target Neighborhood Hits	343	Shared Neighborhood Hits	120
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

PCQAP_MOUSE
NC score	0.072244 (rank : 422)	θ value	6.88961 (rank : 500)
Query Neighborhood Hits	554	Target Neighborhood Hits	506	Shared Neighborhood Hits	86
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

MYST3_MOUSE
NC score	0.071875 (rank : 423)	θ value	0.0252991 (rank : 121)
Query Neighborhood Hits	554	Target Neighborhood Hits	688	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

FGD1_MOUSE
NC score	0.071842 (rank : 424)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	99
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GGN_HUMAN
NC score	0.071777 (rank : 425)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	554	Target Neighborhood Hits	269	Shared Neighborhood Hits	78
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

PPIP2_HUMAN
NC score	0.071740 (rank : 426)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	554	Target Neighborhood Hits	254	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PELP1_HUMAN
NC score	0.071239 (rank : 427)	θ value	1.06291 (rank : 316)
Query Neighborhood Hits	554	Target Neighborhood Hits	596	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

SLY_HUMAN
NC score	0.071154 (rank : 428)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	554	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

RPB1_MOUSE
NC score	0.071092 (rank : 429)	θ value	0.813845 (rank : 296)
Query Neighborhood Hits	554	Target Neighborhood Hits	363	Shared Neighborhood Hits	69
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SF3A1_MOUSE
NC score	0.071018 (rank : 430)	θ value	3.0926 (rank : 420)
Query Neighborhood Hits	554	Target Neighborhood Hits	198	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

ARHGA_MOUSE
NC score	0.070961 (rank : 431)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	554	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SC24D_HUMAN
NC score	0.070946 (rank : 432)	θ value	0.813845 (rank : 297)
Query Neighborhood Hits	554	Target Neighborhood Hits	173	Shared Neighborhood Hits	55
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

PRG4_HUMAN
NC score	0.070815 (rank : 433)	θ value	8.99809 (rank : 541)
Query Neighborhood Hits	554	Target Neighborhood Hits	764	Shared Neighborhood Hits	113
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RPB1_HUMAN
NC score	0.070764 (rank : 434)	θ value	0.813845 (rank : 295)
Query Neighborhood Hits	554	Target Neighborhood Hits	362	Shared Neighborhood Hits	69
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

LDB3_MOUSE
NC score	0.070639 (rank : 435)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	554	Target Neighborhood Hits	510	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

WBP2_MOUSE
NC score	0.070629 (rank : 436)	θ value	0.365318 (rank : 252)
Query Neighborhood Hits	554	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	P97765	Gene names	Wbp2
Domain Architecture
Description	WW domain-binding protein 2 (WBP-2).

BLK_MOUSE
NC score	0.070627 (rank : 437)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	554	Target Neighborhood Hits	992	Shared Neighborhood Hits	133
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MYO15_HUMAN
NC score	0.070432 (rank : 438)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	554	Target Neighborhood Hits	671	Shared Neighborhood Hits	208
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MUC5B_HUMAN
NC score	0.070425 (rank : 439)	θ value	0.0330416 (rank : 131)
Query Neighborhood Hits	554	Target Neighborhood Hits	1020	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

K1543_MOUSE
NC score	0.070273 (rank : 440)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	554	Target Neighborhood Hits	497	Shared Neighborhood Hits	137
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

PRPC_HUMAN
NC score	0.070058 (rank : 441)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	554	Target Neighborhood Hits	165	Shared Neighborhood Hits	42
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

TM108_MOUSE
NC score	0.069891 (rank : 442)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	554	Target Neighborhood Hits	336	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

NRX2B_HUMAN
NC score	0.069829 (rank : 443)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	554	Target Neighborhood Hits	481	Shared Neighborhood Hits	147
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

LCP2_MOUSE
NC score	0.069705 (rank : 444)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	63
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

GAB1_HUMAN
NC score	0.069612 (rank : 445)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	554	Target Neighborhood Hits	279	Shared Neighborhood Hits	97
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAK14_HUMAN
NC score	0.069482 (rank : 446)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	554	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	P62687	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_16p3.3 provirus ancestral Gag polyprotein (Gag polyprotein).

BI2L1_HUMAN
NC score	0.069256 (rank : 447)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PER3_HUMAN
NC score	0.069104 (rank : 448)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	554	Target Neighborhood Hits	479	Shared Neighborhood Hits	137
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

CD248_HUMAN
NC score	0.069088 (rank : 449)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	554	Target Neighborhood Hits	679	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

PO6F2_MOUSE
NC score	0.069067 (rank : 450)	θ value	0.0431538 (rank : 141)
Query Neighborhood Hits	554	Target Neighborhood Hits	639	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PPIP2_MOUSE
NC score	0.068988 (rank : 451)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	554	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

ZN207_HUMAN
NC score	0.068814 (rank : 452)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	554	Target Neighborhood Hits	326	Shared Neighborhood Hits	58
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

CSF1_HUMAN
NC score	0.068782 (rank : 453)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	554	Target Neighborhood Hits	258	Shared Neighborhood Hits	76
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

TENS4_MOUSE
NC score	0.068768 (rank : 454)	θ value	0.163984 (rank : 210)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

ARHGF_HUMAN
NC score	0.068652 (rank : 455)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	554	Target Neighborhood Hits	214	Shared Neighborhood Hits	55
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

GNAS1_MOUSE
NC score	0.068434 (rank : 456)	θ value	0.0736092 (rank : 165)
Query Neighborhood Hits	554	Target Neighborhood Hits	651	Shared Neighborhood Hits	162
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

PDC6I_MOUSE
NC score	0.068197 (rank : 457)	θ value	1.81305 (rank : 363)
Query Neighborhood Hits	554	Target Neighborhood Hits	275	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

MTSS1_HUMAN
NC score	0.068082 (rank : 458)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	554	Target Neighborhood Hits	504	Shared Neighborhood Hits	120
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

SRRM2_HUMAN
NC score	0.067984 (rank : 459)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	554	Target Neighborhood Hits	1296	Shared Neighborhood Hits	164
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

BAT3_HUMAN
NC score	0.067863 (rank : 460)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	554	Target Neighborhood Hits	490	Shared Neighborhood Hits	123
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CSK_HUMAN
NC score	0.067732 (rank : 461)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	554	Target Neighborhood Hits	1009	Shared Neighborhood Hits	136
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.067651 (rank : 462)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	554	Target Neighborhood Hits	1009	Shared Neighborhood Hits	136
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

TXK_MOUSE
NC score	0.067640 (rank : 463)	θ value	8.99809 (rank : 551)
Query Neighborhood Hits	554	Target Neighborhood Hits	980	Shared Neighborhood Hits	140
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SHC1_HUMAN
NC score	0.067623 (rank : 464)	θ value	1.81305 (rank : 368)
Query Neighborhood Hits	554	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GAK13_HUMAN
NC score	0.067298 (rank : 465)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	554	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	P62686	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1p13.3 provirus ancestral Gag polyprotein (Gag polyprotein).

P85B_MOUSE
NC score	0.067253 (rank : 466)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	554	Target Neighborhood Hits	519	Shared Neighborhood Hits	83
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

BAT3_MOUSE
NC score	0.067217 (rank : 467)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	554	Target Neighborhood Hits	518	Shared Neighborhood Hits	129
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

GAB1_MOUSE
NC score	0.066903 (rank : 468)	θ value	6.88961 (rank : 488)
Query Neighborhood Hits	554	Target Neighborhood Hits	233	Shared Neighborhood Hits	74
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CJ108_HUMAN
NC score	0.066755 (rank : 469)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	554	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

ABL1_MOUSE
NC score	0.066665 (rank : 470)	θ value	8.99809 (rank : 518)
Query Neighborhood Hits	554	Target Neighborhood Hits	1178	Shared Neighborhood Hits	161
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

K1543_HUMAN
NC score	0.066496 (rank : 471)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	554	Target Neighborhood Hits	435	Shared Neighborhood Hits	122
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MAP1A_HUMAN
NC score	0.066434 (rank : 472)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	554	Target Neighborhood Hits	1626	Shared Neighborhood Hits	206
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

DOK2_MOUSE
NC score	0.066153 (rank : 473)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	554	Target Neighborhood Hits	244	Shared Neighborhood Hits	92
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

ABL1_HUMAN
NC score	0.065997 (rank : 474)	θ value	8.99809 (rank : 517)
Query Neighborhood Hits	554	Target Neighborhood Hits	1220	Shared Neighborhood Hits	156
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

DMRTD_HUMAN
NC score	0.065890 (rank : 475)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	554	Target Neighborhood Hits	216	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

EP400_MOUSE
NC score	0.065812 (rank : 476)	θ value	0.47712 (rank : 256)
Query Neighborhood Hits	554	Target Neighborhood Hits	592	Shared Neighborhood Hits	128
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

JIP2_HUMAN
NC score	0.065728 (rank : 477)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	554	Target Neighborhood Hits	288	Shared Neighborhood Hits	94
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SASH1_HUMAN
NC score	0.065726 (rank : 478)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	554	Target Neighborhood Hits	292	Shared Neighborhood Hits	103
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

CO002_HUMAN
NC score	0.065490 (rank : 479)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

MINT_HUMAN
NC score	0.065369 (rank : 480)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	554	Target Neighborhood Hits	1291	Shared Neighborhood Hits	160
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ARHGA_HUMAN
NC score	0.065265 (rank : 481)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	554	Target Neighborhood Hits	187	Shared Neighborhood Hits	29
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

LCK_HUMAN
NC score	0.065212 (rank : 482)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	554	Target Neighborhood Hits	987	Shared Neighborhood Hits	119
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

CSKI2_HUMAN
NC score	0.065154 (rank : 483)	θ value	1.38821 (rank : 326)
Query Neighborhood Hits	554	Target Neighborhood Hits	747	Shared Neighborhood Hits	118
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CABIN_HUMAN
NC score	0.065046 (rank : 484)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	554	Target Neighborhood Hits	490	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

GRB14_MOUSE
NC score	0.064683 (rank : 485)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	554	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SMR3A_HUMAN
NC score	0.064677 (rank : 486)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	554	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

ATX7_HUMAN
NC score	0.064611 (rank : 487)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	554	Target Neighborhood Hits	351	Shared Neighborhood Hits	115
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

LCK_MOUSE
NC score	0.064463 (rank : 488)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	554	Target Neighborhood Hits	981	Shared Neighborhood Hits	117
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SASH1_MOUSE
NC score	0.064325 (rank : 489)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	84
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21B_MOUSE
NC score	0.064318 (rank : 490)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

AUTS2_HUMAN
NC score	0.064250 (rank : 491)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	554	Target Neighborhood Hits	342	Shared Neighborhood Hits	86
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

TEC_HUMAN
NC score	0.064183 (rank : 492)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	554	Target Neighborhood Hits	1006	Shared Neighborhood Hits	143
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ANK2_HUMAN
NC score	0.064144 (rank : 493)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	554	Target Neighborhood Hits	1615	Shared Neighborhood Hits	210
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

SF3A1_HUMAN
NC score	0.063985 (rank : 494)	θ value	4.03905 (rank : 453)
Query Neighborhood Hits	554	Target Neighborhood Hits	199	Shared Neighborhood Hits	55
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

LDB3_HUMAN
NC score	0.063858 (rank : 495)	θ value	0.00665767 (rank : 82)
Query Neighborhood Hits	554	Target Neighborhood Hits	497	Shared Neighborhood Hits	77
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

SH21B_HUMAN
NC score	0.063657 (rank : 496)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

GRB14_HUMAN
NC score	0.063409 (rank : 497)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	554	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ZYX_HUMAN
NC score	0.063335 (rank : 498)	θ value	1.38821 (rank : 342)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

TGON2_HUMAN
NC score	0.063302 (rank : 499)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	554	Target Neighborhood Hits	1037	Shared Neighborhood Hits	134
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TEC_MOUSE
NC score	0.063155 (rank : 500)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	554	Target Neighborhood Hits	1006	Shared Neighborhood Hits	142
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RCOR2_MOUSE
NC score	0.063100 (rank : 501)	θ value	0.0961366 (rank : 187)
Query Neighborhood Hits	554	Target Neighborhood Hits	107	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C796, Q9JMK4	Gene names	Rcor2
Domain Architecture	No domain graphic available
Description	REST corepressor 2 (M-CoREST).

PRR8_HUMAN
NC score	0.062936 (rank : 502)	θ value	8.99809 (rank : 542)
Query Neighborhood Hits	554	Target Neighborhood Hits	217	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

HAPIP_HUMAN
NC score	0.062884 (rank : 503)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	554	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

CIKS_HUMAN
NC score	0.062759 (rank : 504)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	554	Target Neighborhood Hits	60	Shared Neighborhood Hits	18
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CK056_MOUSE
NC score	0.062603 (rank : 505)	θ value	0.0431538 (rank : 136)
Query Neighborhood Hits	554	Target Neighborhood Hits	42	Shared Neighborhood Hits	18
SwissProt Accessions	Q3U2I3, Q3TWF5, Q6P543, Q80T93, Q811J6, Q8BI34, Q8VE55	Gene names	Kiaa1759
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf56 homolog.

TXK_HUMAN
NC score	0.062518 (rank : 506)	θ value	8.99809 (rank : 550)
Query Neighborhood Hits	554	Target Neighborhood Hits	971	Shared Neighborhood Hits	131
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ARHGB_HUMAN
NC score	0.062448 (rank : 507)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	554	Target Neighborhood Hits	375	Shared Neighborhood Hits	46
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.062419 (rank : 508)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	554	Target Neighborhood Hits	351	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RCOR2_HUMAN
NC score	0.062404 (rank : 509)	θ value	0.125558 (rank : 199)
Query Neighborhood Hits	554	Target Neighborhood Hits	114	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IZ40, Q96FP3	Gene names	RCOR2
Domain Architecture	No domain graphic available
Description	REST corepressor 2.

SEPT9_HUMAN
NC score	0.062305 (rank : 510)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	554	Target Neighborhood Hits	706	Shared Neighborhood Hits	176
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

PTN23_HUMAN
NC score	0.062232 (rank : 511)	θ value	0.365318 (rank : 249)
Query Neighborhood Hits	554	Target Neighborhood Hits	646	Shared Neighborhood Hits	109
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

ATX2_HUMAN
NC score	0.062150 (rank : 512)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	554	Target Neighborhood Hits	375	Shared Neighborhood Hits	82
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

PDLI7_HUMAN
NC score	0.062145 (rank : 513)	θ value	0.813845 (rank : 292)
Query Neighborhood Hits	554	Target Neighborhood Hits	547	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

ECT2_MOUSE
NC score	0.062112 (rank : 514)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	554	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGC_MOUSE
NC score	0.061479 (rank : 515)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	554	Target Neighborhood Hits	344	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITK_HUMAN
NC score	0.061426 (rank : 516)	θ value	6.88961 (rank : 491)
Query Neighborhood Hits	554	Target Neighborhood Hits	1016	Shared Neighborhood Hits	138
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

VASP_HUMAN
NC score	0.061329 (rank : 517)	θ value	3.0926 (rank : 426)
Query Neighborhood Hits	554	Target Neighborhood Hits	201	Shared Neighborhood Hits	56
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

ATX7_MOUSE
NC score	0.061279 (rank : 518)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	554	Target Neighborhood Hits	328	Shared Neighborhood Hits	116
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

CO039_HUMAN
NC score	0.061149 (rank : 519)	θ value	4.03905 (rank : 434)
Query Neighborhood Hits	554	Target Neighborhood Hits	264	Shared Neighborhood Hits	76
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

SYNPO_MOUSE
NC score	0.061082 (rank : 520)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	554	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

AB1IP_HUMAN
NC score	0.061002 (rank : 521)	θ value	8.99809 (rank : 516)
Query Neighborhood Hits	554	Target Neighborhood Hits	213	Shared Neighborhood Hits	59
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

DIAP1_MOUSE
NC score	0.060970 (rank : 522)	θ value	2.36792 (rank : 378)
Query Neighborhood Hits	554	Target Neighborhood Hits	839	Shared Neighborhood Hits	88
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

TAF6_MOUSE
NC score	0.060962 (rank : 523)	θ value	0.163984 (rank : 209)
Query Neighborhood Hits	554	Target Neighborhood Hits	110	Shared Neighborhood Hits	30
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

EPN1_HUMAN
NC score	0.060758 (rank : 524)	θ value	0.47712 (rank : 257)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

MYO15_MOUSE
NC score	0.060628 (rank : 525)	θ value	1.81305 (rank : 359)
Query Neighborhood Hits	554	Target Neighborhood Hits	467	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

DAPP1_HUMAN
NC score	0.060383 (rank : 526)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.060075 (rank : 527)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	554	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ECT2_HUMAN
NC score	0.059925 (rank : 528)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	554	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

DAB1_HUMAN
NC score	0.059911 (rank : 529)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	554	Target Neighborhood Hits	219	Shared Neighborhood Hits	85
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

TRI66_MOUSE
NC score	0.059731 (rank : 530)	θ value	6.88961 (rank : 511)
Query Neighborhood Hits	554	Target Neighborhood Hits	491	Shared Neighborhood Hits	97
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

SFR15_HUMAN
NC score	0.059713 (rank : 531)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	554	Target Neighborhood Hits	368	Shared Neighborhood Hits	74
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

IL3B2_MOUSE
NC score	0.059505 (rank : 532)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	554	Target Neighborhood Hits	372	Shared Neighborhood Hits	128
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

ABL2_HUMAN
NC score	0.059480 (rank : 533)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	554	Target Neighborhood Hits	1045	Shared Neighborhood Hits	129
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

3BP1_HUMAN
NC score	0.059300 (rank : 534)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	554	Target Neighborhood Hits	376	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ENAH_HUMAN
NC score	0.059238 (rank : 535)	θ value	4.03905 (rank : 440)
Query Neighborhood Hits	554	Target Neighborhood Hits	784	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

JPH2_HUMAN
NC score	0.059170 (rank : 536)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	554	Target Neighborhood Hits	639	Shared Neighborhood Hits	147
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

RFX1_HUMAN
NC score	0.058940 (rank : 537)	θ value	2.36792 (rank : 390)
Query Neighborhood Hits	554	Target Neighborhood Hits	256	Shared Neighborhood Hits	84
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

TAB3_HUMAN
NC score	0.058906 (rank : 538)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

ARHG1_MOUSE
NC score	0.058842 (rank : 539)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	554	Target Neighborhood Hits	266	Shared Neighborhood Hits	65
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ECM1_HUMAN
NC score	0.058818 (rank : 540)	θ value	6.88961 (rank : 484)
Query Neighborhood Hits	554	Target Neighborhood Hits	182	Shared Neighborhood Hits	73
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

ARHG1_HUMAN
NC score	0.058723 (rank : 541)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	554	Target Neighborhood Hits	176	Shared Neighborhood Hits	32
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

PKHG4_HUMAN
NC score	0.058710 (rank : 542)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	554	Target Neighborhood Hits	200	Shared Neighborhood Hits	43
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

GRB7_MOUSE
NC score	0.058641 (rank : 543)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	554	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

PER2_MOUSE
NC score	0.058594 (rank : 544)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	554	Target Neighborhood Hits	325	Shared Neighborhood Hits	104
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

BLNK_HUMAN
NC score	0.058592 (rank : 545)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

EPN1_MOUSE
NC score	0.058494 (rank : 546)	θ value	1.06291 (rank : 308)
Query Neighborhood Hits	554	Target Neighborhood Hits	240	Shared Neighborhood Hits	72
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

BI2L1_MOUSE
NC score	0.058325 (rank : 547)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	554	Target Neighborhood Hits	197	Shared Neighborhood Hits	60
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SHC3_MOUSE
NC score	0.058288 (rank : 548)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

NU214_HUMAN
NC score	0.058241 (rank : 549)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	554	Target Neighborhood Hits	657	Shared Neighborhood Hits	107
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

ZYX_MOUSE
NC score	0.058127 (rank : 550)	θ value	6.88961 (rank : 515)
Query Neighborhood Hits	554	Target Neighborhood Hits	347	Shared Neighborhood Hits	67
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

SH22A_MOUSE
NC score	0.058076 (rank : 551)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	554	Target Neighborhood Hits	179	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

RGNEF_MOUSE
NC score	0.057792 (rank : 552)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	554	Target Neighborhood Hits	641	Shared Neighborhood Hits	62
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SRMS_MOUSE
NC score	0.057727 (rank : 553)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	554	Target Neighborhood Hits	964	Shared Neighborhood Hits	110
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SELV_HUMAN
NC score	0.057634 (rank : 554)	θ value	8.99809 (rank : 546)
Query Neighborhood Hits	554	Target Neighborhood Hits	118	Shared Neighborhood Hits	37
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

K1683_HUMAN
NC score	0.057491 (rank : 555)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	554	Target Neighborhood Hits	240	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

SYP2L_HUMAN
NC score	0.057364 (rank : 556)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	554	Target Neighborhood Hits	400	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

CK024_MOUSE
NC score	0.057317 (rank : 557)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	554	Target Neighborhood Hits	307	Shared Neighborhood Hits	64
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

EPN3_MOUSE
NC score	0.057190 (rank : 558)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	554	Target Neighborhood Hits	312	Shared Neighborhood Hits	89
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

ACK1_HUMAN
NC score	0.057133 (rank : 559)	θ value	2.36792 (rank : 372)
Query Neighborhood Hits	554	Target Neighborhood Hits	1140	Shared Neighborhood Hits	188
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

TENS4_HUMAN
NC score	0.056930 (rank : 560)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	554	Target Neighborhood Hits	214	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TP53B_MOUSE
NC score	0.056901 (rank : 561)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	554	Target Neighborhood Hits	644	Shared Neighborhood Hits	101
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

RBM12_MOUSE
NC score	0.056898 (rank : 562)	θ value	3.0926 (rank : 416)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

SHC1_MOUSE
NC score	0.056889 (rank : 563)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	554	Target Neighborhood Hits	180	Shared Neighborhood Hits	61
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

PHLB1_HUMAN
NC score	0.056872 (rank : 564)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	554	Target Neighborhood Hits	1038	Shared Neighborhood Hits	150
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

APS_HUMAN
NC score	0.056676 (rank : 565)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SPRR3_HUMAN
NC score	0.056599 (rank : 566)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	554	Target Neighborhood Hits	102	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

BCR_HUMAN
NC score	0.056567 (rank : 567)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	40
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

IWS1_MOUSE
NC score	0.056440 (rank : 568)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	554	Target Neighborhood Hits	1258	Shared Neighborhood Hits	151
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K1688_HUMAN
NC score	0.056383 (rank : 569)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	554	Target Neighborhood Hits	217	Shared Neighborhood Hits	61
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

SSBP3_HUMAN
NC score	0.056335 (rank : 570)	θ value	0.813845 (rank : 299)
Query Neighborhood Hits	554	Target Neighborhood Hits	132	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BWW4, Q9BTM0, Q9BWW3	Gene names	SSBP3, SSDP, SSDP1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein).

SSBP3_MOUSE
NC score	0.056335 (rank : 571)	θ value	0.813845 (rank : 300)
Query Neighborhood Hits	554	Target Neighborhood Hits	132	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D032, Q99LC6, Q9EQP3	Gene names	Ssbp3, Last, Ssdp1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein) (Lck-associated signal transducer).

SHD_HUMAN
NC score	0.056315 (rank : 572)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	64
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SYNJ1_MOUSE
NC score	0.056255 (rank : 573)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	554	Target Neighborhood Hits	516	Shared Neighborhood Hits	137
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

NFRKB_HUMAN
NC score	0.056186 (rank : 574)	θ value	3.0926 (rank : 409)
Query Neighborhood Hits	554	Target Neighborhood Hits	211	Shared Neighborhood Hits	50
SwissProt Accessions	Q6P4R8, Q12869, Q15312, Q9H048	Gene names	NFRKB
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

FGD3_MOUSE
NC score	0.056163 (rank : 575)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	554	Target Neighborhood Hits	257	Shared Neighborhood Hits	31
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ENAM_HUMAN
NC score	0.056114 (rank : 576)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

DLG5_HUMAN
NC score	0.056112 (rank : 577)	θ value	0.125558 (rank : 193)
Query Neighborhood Hits	554	Target Neighborhood Hits	1088	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

PYGO2_HUMAN
NC score	0.056025 (rank : 578)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	554	Target Neighborhood Hits	189	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

TAF6_HUMAN
NC score	0.056025 (rank : 579)	θ value	0.47712 (rank : 268)
Query Neighborhood Hits	554	Target Neighborhood Hits	127	Shared Neighborhood Hits	29
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

ATX1_MOUSE
NC score	0.055789 (rank : 580)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	554	Target Neighborhood Hits	264	Shared Neighborhood Hits	85
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

SHC2_HUMAN
NC score	0.055760 (rank : 581)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	554	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

FGD4_MOUSE
NC score	0.055678 (rank : 582)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	554	Target Neighborhood Hits	227	Shared Neighborhood Hits	34
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

BAZ2A_HUMAN
NC score	0.055375 (rank : 583)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	554	Target Neighborhood Hits	780	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

AB1IP_MOUSE
NC score	0.055343 (rank : 584)	θ value	3.0926 (rank : 395)
Query Neighborhood Hits	554	Target Neighborhood Hits	181	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CPSF7_MOUSE
NC score	0.055338 (rank : 585)	θ value	3.0926 (rank : 399)
Query Neighborhood Hits	554	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BTV2, Q3TNF1, Q8BKE7, Q8CFS8	Gene names	Cpsf7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7.

CPSF7_HUMAN
NC score	0.055282 (rank : 586)	θ value	3.0926 (rank : 398)
Query Neighborhood Hits	554	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N684, Q7Z3H9, Q9H025, Q9H9V1	Gene names	CPSF7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Pre-mRNA cleavage factor Im 59 kDa subunit).

RCOR3_MOUSE
NC score	0.055258 (rank : 587)	θ value	0.62314 (rank : 278)
Query Neighborhood Hits	554	Target Neighborhood Hits	110	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PGA0	Gene names	Rcor3
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

MBB1A_HUMAN
NC score	0.055252 (rank : 588)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	554	Target Neighborhood Hits	665	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

CS007_MOUSE
NC score	0.055240 (rank : 589)	θ value	4.03905 (rank : 436)
Query Neighborhood Hits	554	Target Neighborhood Hits	464	Shared Neighborhood Hits	89
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

ANTR1_MOUSE
NC score	0.055184 (rank : 590)	θ value	2.36792 (rank : 373)
Query Neighborhood Hits	554	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

FGD4_HUMAN
NC score	0.055180 (rank : 591)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	554	Target Neighborhood Hits	219	Shared Neighborhood Hits	29
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_HUMAN
NC score	0.055148 (rank : 592)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

SHE_MOUSE
NC score	0.055038 (rank : 593)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	554	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ACK1_MOUSE
NC score	0.055026 (rank : 594)	θ value	0.813845 (rank : 286)
Query Neighborhood Hits	554	Target Neighborhood Hits	1080	Shared Neighborhood Hits	174
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

SOX30_MOUSE
NC score	0.054963 (rank : 595)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	131
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

PDZD2_HUMAN
NC score	0.054788 (rank : 596)	θ value	8.99809 (rank : 539)
Query Neighborhood Hits	554	Target Neighborhood Hits	772	Shared Neighborhood Hits	128
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

EM55_HUMAN
NC score	0.054487 (rank : 597)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	91
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MAVS_HUMAN
NC score	0.054484 (rank : 598)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	554	Target Neighborhood Hits	271	Shared Neighborhood Hits	75
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

SHC2_MOUSE
NC score	0.054407 (rank : 599)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	554	Target Neighborhood Hits	144	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

FGD3_HUMAN
NC score	0.054364 (rank : 600)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	554	Target Neighborhood Hits	249	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

SHC3_HUMAN
NC score	0.054304 (rank : 601)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	554	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ITK_MOUSE
NC score	0.054256 (rank : 602)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	554	Target Neighborhood Hits	985	Shared Neighborhood Hits	122
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

NCOR2_HUMAN
NC score	0.054160 (rank : 603)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	554	Target Neighborhood Hits	870	Shared Neighborhood Hits	128
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

GRB10_MOUSE
NC score	0.054122 (rank : 604)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

PO6F2_HUMAN
NC score	0.054113 (rank : 605)	θ value	0.813845 (rank : 294)
Query Neighborhood Hits	554	Target Neighborhood Hits	618	Shared Neighborhood Hits	96
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

MAML1_MOUSE
NC score	0.054093 (rank : 606)	θ value	6.88961 (rank : 495)
Query Neighborhood Hits	554	Target Neighborhood Hits	279	Shared Neighborhood Hits	75
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

PHLA1_HUMAN
NC score	0.054034 (rank : 607)	θ value	2.36792 (rank : 387)
Query Neighborhood Hits	554	Target Neighborhood Hits	121	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

GRB7_HUMAN
NC score	0.053891 (rank : 608)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

LNK_HUMAN
NC score	0.053821 (rank : 609)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHE_HUMAN
NC score	0.053777 (rank : 610)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	554	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MAML2_HUMAN
NC score	0.053729 (rank : 611)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	554	Target Neighborhood Hits	360	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

SYP2L_MOUSE
NC score	0.053704 (rank : 612)	θ value	1.06291 (rank : 321)
Query Neighborhood Hits	554	Target Neighborhood Hits	289	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

BAIP2_MOUSE
NC score	0.053650 (rank : 613)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	554	Target Neighborhood Hits	185	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

TAU_HUMAN
NC score	0.053536 (rank : 614)	θ value	6.88961 (rank : 509)
Query Neighborhood Hits	554	Target Neighborhood Hits	448	Shared Neighborhood Hits	97
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

SHB_MOUSE
NC score	0.053519 (rank : 615)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	554	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

MAML3_HUMAN
NC score	0.053292 (rank : 616)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	554	Target Neighborhood Hits	323	Shared Neighborhood Hits	74
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

P55G_HUMAN
NC score	0.053229 (rank : 617)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	554	Target Neighborhood Hits	451	Shared Neighborhood Hits	58
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

RC3H1_HUMAN
NC score	0.053226 (rank : 618)	θ value	6.88961 (rank : 502)
Query Neighborhood Hits	554	Target Neighborhood Hits	433	Shared Neighborhood Hits	114
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

3BP2_HUMAN
NC score	0.053211 (rank : 619)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	554	Target Neighborhood Hits	296	Shared Neighborhood Hits	103
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CTDP1_HUMAN
NC score	0.052908 (rank : 620)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	554	Target Neighborhood Hits	416	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

ALMS1_HUMAN
NC score	0.052799 (rank : 621)	θ value	1.06291 (rank : 305)
Query Neighborhood Hits	554	Target Neighborhood Hits	356	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

BAIP2_HUMAN
NC score	0.052774 (rank : 622)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	554	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

TENS1_HUMAN
NC score	0.052741 (rank : 623)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	554	Target Neighborhood Hits	400	Shared Neighborhood Hits	107
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

RBM16_HUMAN
NC score	0.052687 (rank : 624)	θ value	1.38821 (rank : 334)
Query Neighborhood Hits	554	Target Neighborhood Hits	300	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

FGD2_MOUSE
NC score	0.052603 (rank : 625)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	554	Target Neighborhood Hits	163	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ALEX_MOUSE
NC score	0.052490 (rank : 626)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	554	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

SHB_HUMAN
NC score	0.052431 (rank : 627)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	554	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

JIP2_MOUSE
NC score	0.052283 (rank : 628)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	554	Target Neighborhood Hits	144	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

CRTC1_MOUSE
NC score	0.052233 (rank : 629)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	554	Target Neighborhood Hits	230	Shared Neighborhood Hits	64
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

LBC_HUMAN
NC score	0.052198 (rank : 630)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	554	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

TAU_MOUSE
NC score	0.052185 (rank : 631)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	554	Target Neighborhood Hits	502	Shared Neighborhood Hits	100
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

MEF2B_MOUSE
NC score	0.052096 (rank : 632)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	554	Target Neighborhood Hits	218	Shared Neighborhood Hits	73
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

MATK_HUMAN
NC score	0.052075 (rank : 633)	θ value	1.81305 (rank : 355)
Query Neighborhood Hits	554	Target Neighborhood Hits	954	Shared Neighborhood Hits	86
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MEGF9_MOUSE
NC score	0.052054 (rank : 634)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	554	Target Neighborhood Hits	896	Shared Neighborhood Hits	160
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

EM55_MOUSE
NC score	0.051897 (rank : 635)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	554	Target Neighborhood Hits	221	Shared Neighborhood Hits	86
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SRBP1_MOUSE
NC score	0.051892 (rank : 636)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	554	Target Neighborhood Hits	384	Shared Neighborhood Hits	115
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRMS_HUMAN
NC score	0.051872 (rank : 637)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	554	Target Neighborhood Hits	946	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

GRB10_HUMAN
NC score	0.051859 (rank : 638)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	554	Target Neighborhood Hits	147	Shared Neighborhood Hits	50
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

P55G_MOUSE
NC score	0.051825 (rank : 639)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	554	Target Neighborhood Hits	401	Shared Neighborhood Hits	55
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CG1_HUMAN
NC score	0.051742 (rank : 640)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	554	Target Neighborhood Hits	222	Shared Neighborhood Hits	69
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

LOXL1_MOUSE
NC score	0.051552 (rank : 641)	θ value	0.0252991 (rank : 118)
Query Neighborhood Hits	554	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

MATK_MOUSE
NC score	0.051302 (rank : 642)	θ value	1.81305 (rank : 356)
Query Neighborhood Hits	554	Target Neighborhood Hits	952	Shared Neighborhood Hits	90
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SHD_MOUSE
NC score	0.051235 (rank : 643)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	554	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

PRP5_HUMAN
NC score	0.051002 (rank : 644)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	26
SwissProt Accessions	P04281	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide IB-1.

NUP53_HUMAN
NC score	0.050977 (rank : 645)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

DOT1L_HUMAN
NC score	0.050708 (rank : 646)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	554	Target Neighborhood Hits	660	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

K0460_MOUSE
NC score	0.050449 (rank : 647)	θ value	3.0926 (rank : 407)
Query Neighborhood Hits	554	Target Neighborhood Hits	374	Shared Neighborhood Hits	61
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

ZIMP7_HUMAN
NC score	0.050446 (rank : 648)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	554	Target Neighborhood Hits	290	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

IL3RB_MOUSE
NC score	0.050367 (rank : 649)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	554	Target Neighborhood Hits	355	Shared Neighborhood Hits	115
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

EMSY_MOUSE
NC score	0.050207 (rank : 650)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	554	Target Neighborhood Hits	294	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

DOK1_MOUSE
NC score	0.050053 (rank : 651)	θ value	8.99809 (rank : 526)
Query Neighborhood Hits	554	Target Neighborhood Hits	82	Shared Neighborhood Hits	30
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

WNK2_HUMAN
NC score	0.049307 (rank : 652)	θ value	4.03905 (rank : 460)
Query Neighborhood Hits	554	Target Neighborhood Hits	1407	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

S3TC1_HUMAN
NC score	0.049159 (rank : 653)	θ value	3.0926 (rank : 418)
Query Neighborhood Hits	554	Target Neighborhood Hits	78	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

PHLA1_MOUSE
NC score	0.048992 (rank : 654)	θ value	2.36792 (rank : 388)
Query Neighborhood Hits	554	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	Q62392, Q3TY48, Q3UG87	Gene names	Phlda1, Tdag51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Proline- and glutamine-rich protein) (PQR protein).

MKL1_HUMAN
NC score	0.048394 (rank : 655)	θ value	1.06291 (rank : 314)
Query Neighborhood Hits	554	Target Neighborhood Hits	232	Shared Neighborhood Hits	44
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

RCOR3_HUMAN
NC score	0.048330 (rank : 656)	θ value	3.0926 (rank : 417)
Query Neighborhood Hits	554	Target Neighborhood Hits	161	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P2K3, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83	Gene names	RCOR3, KIAA1343
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

CN092_MOUSE
NC score	0.048297 (rank : 657)	θ value	1.06291 (rank : 306)
Query Neighborhood Hits	554	Target Neighborhood Hits	206	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

LPP_MOUSE
NC score	0.047973 (rank : 658)	θ value	0.47712 (rank : 260)
Query Neighborhood Hits	554	Target Neighborhood Hits	247	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BFW7, Q5U407, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101	Gene names	Lpp
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner homolog.

ZN598_HUMAN
NC score	0.047572 (rank : 659)	θ value	3.0926 (rank : 430)
Query Neighborhood Hits	554	Target Neighborhood Hits	339	Shared Neighborhood Hits	48
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

APXL_HUMAN
NC score	0.047473 (rank : 660)	θ value	8.99809 (rank : 520)
Query Neighborhood Hits	554	Target Neighborhood Hits	553	Shared Neighborhood Hits	77
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

EP400_HUMAN
NC score	0.047439 (rank : 661)	θ value	8.99809 (rank : 528)
Query Neighborhood Hits	554	Target Neighborhood Hits	556	Shared Neighborhood Hits	106
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

ETV5_MOUSE
NC score	0.047019 (rank : 662)	θ value	4.03905 (rank : 441)
Query Neighborhood Hits	554	Target Neighborhood Hits	328	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

FUBP2_HUMAN
NC score	0.046793 (rank : 663)	θ value	0.0330416 (rank : 130)
Query Neighborhood Hits	554	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q92945, O00301, Q9UNT5, Q9UQH5	Gene names	KHSRP, FUBP2
Domain Architecture
Description	Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (p75).

AAK1_HUMAN
NC score	0.046315 (rank : 664)	θ value	1.81305 (rank : 343)
Query Neighborhood Hits	554	Target Neighborhood Hits	1077	Shared Neighborhood Hits	150
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

WDR33_HUMAN
NC score	0.046061 (rank : 665)	θ value	0.365318 (rank : 253)
Query Neighborhood Hits	554	Target Neighborhood Hits	638	Shared Neighborhood Hits	93
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

PDCD7_HUMAN
NC score	0.045769 (rank : 666)	θ value	4.03905 (rank : 450)
Query Neighborhood Hits	554	Target Neighborhood Hits	255	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N8D1, Q96AK8, Q9Y6D7	Gene names	PDCD7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18) (HES18).

ANTR1_HUMAN
NC score	0.045374 (rank : 667)	θ value	8.99809 (rank : 519)
Query Neighborhood Hits	554	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H6X2, Q96P02, Q9NVP3	Gene names	ANTXR1, ATR, TEM8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

SPEG_MOUSE
NC score	0.043961 (rank : 668)	θ value	0.125558 (rank : 201)
Query Neighborhood Hits	554	Target Neighborhood Hits	1959	Shared Neighborhood Hits	222
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WHRN_MOUSE
NC score	0.043718 (rank : 669)	θ value	1.06291 (rank : 325)
Query Neighborhood Hits	554	Target Neighborhood Hits	412	Shared Neighborhood Hits	82
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

SIN3A_MOUSE
NC score	0.043657 (rank : 670)	θ value	1.38821 (rank : 337)
Query Neighborhood Hits	554	Target Neighborhood Hits	169	Shared Neighborhood Hits	41
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SMOO_HUMAN
NC score	0.043361 (rank : 671)	θ value	6.88961 (rank : 505)
Query Neighborhood Hits	554	Target Neighborhood Hits	391	Shared Neighborhood Hits	67
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

K0460_HUMAN
NC score	0.042920 (rank : 672)	θ value	3.0926 (rank : 406)
Query Neighborhood Hits	554	Target Neighborhood Hits	357	Shared Neighborhood Hits	51
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

SAM68_HUMAN
NC score	0.042873 (rank : 673)	θ value	0.62314 (rank : 281)
Query Neighborhood Hits	554	Target Neighborhood Hits	68	Shared Neighborhood Hits	16
SwissProt Accessions	Q07666, Q6PJX7, Q8NB97, Q99760	Gene names	KHDRBS1, SAM68
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

IRS2_MOUSE
NC score	0.042721 (rank : 674)	θ value	1.06291 (rank : 313)
Query Neighborhood Hits	554	Target Neighborhood Hits	248	Shared Neighborhood Hits	51
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

RFX1_MOUSE
NC score	0.042133 (rank : 675)	θ value	0.47712 (rank : 266)
Query Neighborhood Hits	554	Target Neighborhood Hits	181	Shared Neighborhood Hits	50
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

SIN3A_HUMAN
NC score	0.042041 (rank : 676)	θ value	3.0926 (rank : 422)
Query Neighborhood Hits	554	Target Neighborhood Hits	180	Shared Neighborhood Hits	51
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

ZN598_MOUSE
NC score	0.041828 (rank : 677)	θ value	0.47712 (rank : 269)
Query Neighborhood Hits	554	Target Neighborhood Hits	255	Shared Neighborhood Hits	25
SwissProt Accessions	Q80YR4, Q6KAT0, Q8R3S1	Gene names	Znf598, Zfp598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

PHC2_MOUSE
NC score	0.041633 (rank : 678)	θ value	8.99809 (rank : 540)
Query Neighborhood Hits	554	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

MGR1_HUMAN
NC score	0.041503 (rank : 679)	θ value	0.00298849 (rank : 62)
Query Neighborhood Hits	554	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q13255, Q13256, Q14757, Q14758, Q5VTF7, Q5VTF8, Q9NU10, Q9UGS9, Q9UGT0	Gene names	GRM1, GPRC1A, MGLUR1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

X3CL1_HUMAN
NC score	0.041445 (rank : 680)	θ value	3.0926 (rank : 428)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	27
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

PLS1_MOUSE
NC score	0.041202 (rank : 681)	θ value	0.813845 (rank : 293)
Query Neighborhood Hits	554	Target Neighborhood Hits	58	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JJ00, O54730, O54731, Q9D1F8	Gene names	Plscr1, Tra1b, Tras1
Domain Architecture
Description	Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Transplantability-associated protein 1) (TRA1) (NOR1).

SMCA4_HUMAN
NC score	0.039848 (rank : 682)	θ value	0.0736092 (rank : 172)
Query Neighborhood Hits	554	Target Neighborhood Hits	597	Shared Neighborhood Hits	86
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

ZO1_HUMAN
NC score	0.039832 (rank : 683)	θ value	6.88961 (rank : 513)
Query Neighborhood Hits	554	Target Neighborhood Hits	474	Shared Neighborhood Hits	94
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SAPS1_MOUSE
NC score	0.038763 (rank : 684)	θ value	1.38821 (rank : 336)
Query Neighborhood Hits	554	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

TTBK1_HUMAN
NC score	0.038412 (rank : 685)	θ value	0.279714 (rank : 232)
Query Neighborhood Hits	554	Target Neighborhood Hits	1058	Shared Neighborhood Hits	86
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

FOXN1_HUMAN
NC score	0.038369 (rank : 686)	θ value	8.99809 (rank : 529)
Query Neighborhood Hits	554	Target Neighborhood Hits	377	Shared Neighborhood Hits	109
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

PER1_MOUSE
NC score	0.037542 (rank : 687)	θ value	4.03905 (rank : 451)
Query Neighborhood Hits	554	Target Neighborhood Hits	235	Shared Neighborhood Hits	59
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

EP15_MOUSE
NC score	0.037244 (rank : 688)	θ value	6.88961 (rank : 485)
Query Neighborhood Hits	554	Target Neighborhood Hits	820	Shared Neighborhood Hits	38
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

PER1_HUMAN
NC score	0.037147 (rank : 689)	θ value	2.36792 (rank : 386)
Query Neighborhood Hits	554	Target Neighborhood Hits	215	Shared Neighborhood Hits	46
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

FRS3_MOUSE
NC score	0.036935 (rank : 690)	θ value	2.36792 (rank : 381)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	44
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

ZN687_HUMAN
NC score	0.036212 (rank : 691)	θ value	1.38821 (rank : 341)
Query Neighborhood Hits	554	Target Neighborhood Hits	1244	Shared Neighborhood Hits	182
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

SF04_HUMAN
NC score	0.035711 (rank : 692)	θ value	3.0926 (rank : 419)
Query Neighborhood Hits	554	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWZ8, O60378, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3	Gene names	SF4
Domain Architecture	No domain graphic available
Description	Splicing factor 4 (RNA-binding protein RBP).

ANX11_MOUSE
NC score	0.035191 (rank : 693)	θ value	0.813845 (rank : 287)
Query Neighborhood Hits	554	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

IRX5_HUMAN
NC score	0.035060 (rank : 694)	θ value	0.0736092 (rank : 167)
Query Neighborhood Hits	554	Target Neighborhood Hits	362	Shared Neighborhood Hits	48
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

TITIN_HUMAN
NC score	0.034920 (rank : 695)	θ value	0.00228821 (rank : 60)
Query Neighborhood Hits	554	Target Neighborhood Hits	2923	Shared Neighborhood Hits	188
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

HTF4_MOUSE
NC score	0.034695 (rank : 696)	θ value	1.06291 (rank : 312)
Query Neighborhood Hits	554	Target Neighborhood Hits	153	Shared Neighborhood Hits	20
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

CD2L7_HUMAN
NC score	0.034489 (rank : 697)	θ value	0.00134147 (rank : 53)
Query Neighborhood Hits	554	Target Neighborhood Hits	1275	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD44_MOUSE
NC score	0.034349 (rank : 698)	θ value	0.365318 (rank : 235)
Query Neighborhood Hits	554	Target Neighborhood Hits	64	Shared Neighborhood Hits	12
SwissProt Accessions	P15379, Q05732, Q61395, Q62060, Q62061, Q62062, Q62063, Q62408, Q62409, Q64296, Q99J14, Q9QYX8	Gene names	Cd44, Ly-24
Domain Architecture
Description	CD44 antigen precursor (Phagocytic glycoprotein 1) (PGP-1) (HUTCH-I) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen Ly-24).

ITF2_HUMAN
NC score	0.034190 (rank : 699)	θ value	0.62314 (rank : 275)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

SPEG_HUMAN
NC score	0.034126 (rank : 700)	θ value	6.88961 (rank : 506)
Query Neighborhood Hits	554	Target Neighborhood Hits	1762	Shared Neighborhood Hits	188
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CN092_HUMAN
NC score	0.033963 (rank : 701)	θ value	2.36792 (rank : 377)
Query Neighborhood Hits	554	Target Neighborhood Hits	143	Shared Neighborhood Hits	29
SwissProt Accessions	O94842	Gene names	C14orf92, KIAA0737
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

DAZP1_HUMAN
NC score	0.033386 (rank : 702)	θ value	0.21417 (rank : 212)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	51
SwissProt Accessions	Q96EP5, Q96MJ3, Q9NRR9	Gene names	DAZAP1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

HNRPG_MOUSE
NC score	0.032812 (rank : 703)	θ value	0.0736092 (rank : 166)
Query Neighborhood Hits	554	Target Neighborhood Hits	223	Shared Neighborhood Hits	17
SwissProt Accessions	O35479	Gene names	Rbmx, Hnrnpg, Hnrpg, Rbmxp1, Rbmxrt
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome).

DACH1_HUMAN
NC score	0.032791 (rank : 704)	θ value	0.47712 (rank : 255)
Query Neighborhood Hits	554	Target Neighborhood Hits	214	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

REXO1_HUMAN
NC score	0.032463 (rank : 705)	θ value	1.81305 (rank : 365)
Query Neighborhood Hits	554	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

CCNK_HUMAN
NC score	0.032439 (rank : 706)	θ value	6.88961 (rank : 481)
Query Neighborhood Hits	554	Target Neighborhood Hits	101	Shared Neighborhood Hits	27
SwissProt Accessions	O75909, Q96B63, Q9NNY9	Gene names	CCNK, CPR4
Domain Architecture
Description	Cyclin-K.

MGR1_MOUSE
NC score	0.032286 (rank : 707)	θ value	0.365318 (rank : 241)
Query Neighborhood Hits	554	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	P97772, Q6AXG4, Q9EPV6	Gene names	Grm1, Gprc1a, Mglur1
Domain Architecture
Description	Metabotropic glutamate receptor 1 precursor (mGluR1).

TRIP6_HUMAN
NC score	0.032020 (rank : 708)	θ value	3.0926 (rank : 424)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	36
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

UBP2L_MOUSE
NC score	0.031939 (rank : 709)	θ value	3.0926 (rank : 425)
Query Neighborhood Hits	554	Target Neighborhood Hits	173	Shared Neighborhood Hits	31
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

ZO1_MOUSE
NC score	0.031914 (rank : 710)	θ value	6.88961 (rank : 514)
Query Neighborhood Hits	554	Target Neighborhood Hits	453	Shared Neighborhood Hits	73
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ERF_HUMAN
NC score	0.031799 (rank : 711)	θ value	0.47712 (rank : 258)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

HTF4_HUMAN
NC score	0.031797 (rank : 712)	θ value	3.0926 (rank : 404)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	18
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

PLS3_MOUSE
NC score	0.031777 (rank : 713)	θ value	1.81305 (rank : 364)
Query Neighborhood Hits	554	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JIZ9	Gene names	Plscr3
Domain Architecture
Description	Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3).

CO3A1_HUMAN
NC score	0.031704 (rank : 714)	θ value	0.0961366 (rank : 177)
Query Neighborhood Hits	554	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

SAM68_MOUSE
NC score	0.031442 (rank : 715)	θ value	5.27518 (rank : 474)
Query Neighborhood Hits	554	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q60749, Q3U8T3, Q60735, Q99M33	Gene names	Khdrbs1
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

AAK1_MOUSE
NC score	0.031352 (rank : 716)	θ value	6.88961 (rank : 478)
Query Neighborhood Hits	554	Target Neighborhood Hits	1051	Shared Neighborhood Hits	132
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

F113A_HUMAN
NC score	0.031350 (rank : 717)	θ value	1.06291 (rank : 309)
Query Neighborhood Hits	554	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1Q7, Q5JUA5, Q5JUA6, Q6PK19, Q86WF5, Q96CG7, Q9H1Q6, Q9H6D1	Gene names	FAM113A, C20orf81
Domain Architecture	No domain graphic available
Description	Protein FAM113A (Sarcoma antigen NY-SAR-23).

SOX17_MOUSE
NC score	0.031170 (rank : 718)	θ value	5.27518 (rank : 475)
Query Neighborhood Hits	554	Target Neighborhood Hits	223	Shared Neighborhood Hits	60
SwissProt Accessions	Q61473, Q61472, Q62248	Gene names	Sox17, Sox-17
Domain Architecture
Description	Transcription factor SOX-17.

DREB_HUMAN
NC score	0.031132 (rank : 719)	θ value	8.99809 (rank : 527)
Query Neighborhood Hits	554	Target Neighborhood Hits	450	Shared Neighborhood Hits	43
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ITF2_MOUSE
NC score	0.030914 (rank : 720)	θ value	1.81305 (rank : 352)
Query Neighborhood Hits	554	Target Neighborhood Hits	154	Shared Neighborhood Hits	11
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

DAZP1_MOUSE
NC score	0.030792 (rank : 721)	θ value	1.38821 (rank : 327)
Query Neighborhood Hits	554	Target Neighborhood Hits	313	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JII5	Gene names	Dazap1
Domain Architecture
Description	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1).

TLN1_HUMAN
NC score	0.030609 (rank : 722)	θ value	0.0961366 (rank : 190)
Query Neighborhood Hits	554	Target Neighborhood Hits	218	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

HNRL1_MOUSE
NC score	0.029727 (rank : 723)	θ value	6.88961 (rank : 489)
Query Neighborhood Hits	554	Target Neighborhood Hits	200	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

CTTB2_HUMAN
NC score	0.029713 (rank : 724)	θ value	6.88961 (rank : 482)
Query Neighborhood Hits	554	Target Neighborhood Hits	1061	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

TLN1_MOUSE
NC score	0.029260 (rank : 725)	θ value	0.21417 (rank : 221)
Query Neighborhood Hits	554	Target Neighborhood Hits	213	Shared Neighborhood Hits	12
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

SC24B_HUMAN
NC score	0.029153 (rank : 726)	θ value	8.99809 (rank : 545)
Query Neighborhood Hits	554	Target Neighborhood Hits	108	Shared Neighborhood Hits	30
SwissProt Accessions	O95487	Gene names	SEC24B
Domain Architecture
Description	Protein transport protein Sec24B (SEC24-related protein B).

GR65_HUMAN
NC score	0.028849 (rank : 727)	θ value	8.99809 (rank : 532)
Query Neighborhood Hits	554	Target Neighborhood Hits	148	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

MYBPH_HUMAN
NC score	0.028779 (rank : 728)	θ value	0.62314 (rank : 276)
Query Neighborhood Hits	554	Target Neighborhood Hits	256	Shared Neighborhood Hits	15
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

WNK4_HUMAN
NC score	0.028604 (rank : 729)	θ value	0.62314 (rank : 285)
Query Neighborhood Hits	554	Target Neighborhood Hits	1043	Shared Neighborhood Hits	89
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

FOXJ2_HUMAN
NC score	0.028384 (rank : 730)	θ value	2.36792 (rank : 379)
Query Neighborhood Hits	554	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

CO4A4_HUMAN
NC score	0.028357 (rank : 731)	θ value	3.0926 (rank : 397)
Query Neighborhood Hits	554	Target Neighborhood Hits	440	Shared Neighborhood Hits	78
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

ANXA7_HUMAN
NC score	0.028172 (rank : 732)	θ value	0.365318 (rank : 233)
Query Neighborhood Hits	554	Target Neighborhood Hits	168	Shared Neighborhood Hits	41
SwissProt Accessions	P20073	Gene names	ANXA7, ANX7, SNX
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

ATBF1_MOUSE
NC score	0.028055 (rank : 733)	θ value	1.81305 (rank : 347)
Query Neighborhood Hits	554	Target Neighborhood Hits	1841	Shared Neighborhood Hits	133
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CO3A1_MOUSE
NC score	0.027320 (rank : 734)	θ value	5.27518 (rank : 466)
Query Neighborhood Hits	554	Target Neighborhood Hits	466	Shared Neighborhood Hits	59
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

FOXN4_HUMAN
NC score	0.027174 (rank : 735)	θ value	6.88961 (rank : 487)
Query Neighborhood Hits	554	Target Neighborhood Hits	248	Shared Neighborhood Hits	75
SwissProt Accessions	Q96NZ1, Q6ZMR4, Q96NZ0	Gene names	FOXN4
Domain Architecture	No domain graphic available
Description	Forkhead box protein N4.

ERF_MOUSE
NC score	0.027093 (rank : 736)	θ value	1.38821 (rank : 329)
Query Neighborhood Hits	554	Target Neighborhood Hits	160	Shared Neighborhood Hits	37
SwissProt Accessions	P70459	Gene names	Erf
Domain Architecture
Description	ETS domain-containing transcription factor ERF.

HNRPG_HUMAN
NC score	0.026930 (rank : 737)	θ value	0.62314 (rank : 274)
Query Neighborhood Hits	554	Target Neighborhood Hits	245	Shared Neighborhood Hits	20
SwissProt Accessions	P38159, Q5JQ67, Q969R3	Gene names	RBMX, HNRPG, RBMXP1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA-binding motif protein, X chromosome) (Glycoprotein p43).

ESX1L_HUMAN
NC score	0.026858 (rank : 738)	θ value	1.38821 (rank : 330)
Query Neighborhood Hits	554	Target Neighborhood Hits	498	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

CENG1_MOUSE
NC score	0.026719 (rank : 739)	θ value	5.27518 (rank : 465)
Query Neighborhood Hits	554	Target Neighborhood Hits	531	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

YAP1_HUMAN
NC score	0.026217 (rank : 740)	θ value	8.99809 (rank : 553)
Query Neighborhood Hits	554	Target Neighborhood Hits	173	Shared Neighborhood Hits	46
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

K0355_HUMAN
NC score	0.026156 (rank : 741)	θ value	8.99809 (rank : 535)
Query Neighborhood Hits	554	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	O15063	Gene names	KIAA0355
Domain Architecture	No domain graphic available
Description	Protein KIAA0355.

DEK_MOUSE
NC score	0.025716 (rank : 742)	θ value	0.813845 (rank : 290)
Query Neighborhood Hits	554	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TNV0, Q80VC5, Q8BZV6	Gene names	Dek
Domain Architecture	No domain graphic available
Description	Protein DEK.

MEGF9_HUMAN
NC score	0.025194 (rank : 743)	θ value	0.0961366 (rank : 182)
Query Neighborhood Hits	554	Target Neighborhood Hits	557	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

DAZL_MOUSE
NC score	0.024326 (rank : 744)	θ value	0.62314 (rank : 271)
Query Neighborhood Hits	554	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q64368	Gene names	Dazl, Dazl1, Dazla
Domain Architecture
Description	Deleted in azoospermia-like (DAZ-like autosomal) (Deleted in azoospermia-like 1).

MK07_MOUSE
NC score	0.024151 (rank : 745)	θ value	0.365318 (rank : 242)
Query Neighborhood Hits	554	Target Neighborhood Hits	1054	Shared Neighborhood Hits	101
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

CENG1_HUMAN
NC score	0.023554 (rank : 746)	θ value	5.27518 (rank : 464)
Query Neighborhood Hits	554	Target Neighborhood Hits	544	Shared Neighborhood Hits	36
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

ZO2_MOUSE
NC score	0.023373 (rank : 747)	θ value	2.36792 (rank : 394)
Query Neighborhood Hits	554	Target Neighborhood Hits	296	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

BTBD7_MOUSE
NC score	0.023368 (rank : 748)	θ value	4.03905 (rank : 432)
Query Neighborhood Hits	554	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

CCDC9_HUMAN
NC score	0.023335 (rank : 749)	θ value	5.27518 (rank : 463)
Query Neighborhood Hits	554	Target Neighborhood Hits	175	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

MACF1_MOUSE
NC score	0.022888 (rank : 750)	θ value	0.47712 (rank : 261)
Query Neighborhood Hits	554	Target Neighborhood Hits	1313	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

ZDHC8_HUMAN
NC score	0.022392 (rank : 751)	θ value	8.99809 (rank : 554)
Query Neighborhood Hits	554	Target Neighborhood Hits	234	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

LITAF_HUMAN
NC score	0.021458 (rank : 752)	θ value	4.03905 (rank : 446)
Query Neighborhood Hits	554	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q99732, Q9C0L6	Gene names	LITAF, PIG7, SIMPLE
Domain Architecture	No domain graphic available
Description	Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS- induced TNF-alpha factor) (p53-induced protein 7) (Small integral membrane protein of lysosome/late endosome).

LOXL1_HUMAN
NC score	0.020978 (rank : 753)	θ value	6.88961 (rank : 493)
Query Neighborhood Hits	554	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

UBQL4_HUMAN
NC score	0.020864 (rank : 754)	θ value	1.38821 (rank : 340)
Query Neighborhood Hits	554	Target Neighborhood Hits	117	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NRR5, Q9BR98, Q9UHX4	Gene names	UBQLN4, C1orf6, UBIN
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

HDGF_HUMAN
NC score	0.020437 (rank : 755)	θ value	2.36792 (rank : 382)
Query Neighborhood Hits	554	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	P51858, Q5SZ09	Gene names	HDGF, HMG1L2
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF) (High-mobility group protein 1- like 2) (HMG-1L2).

EMIL2_HUMAN
NC score	0.019963 (rank : 756)	θ value	0.62314 (rank : 272)
Query Neighborhood Hits	554	Target Neighborhood Hits	573	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

NFAT5_MOUSE
NC score	0.019770 (rank : 757)	θ value	5.27518 (rank : 471)
Query Neighborhood Hits	554	Target Neighborhood Hits	162	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

IL2RB_MOUSE
NC score	0.019585 (rank : 758)	θ value	8.99809 (rank : 534)
Query Neighborhood Hits	554	Target Neighborhood Hits	51	Shared Neighborhood Hits	5
SwissProt Accessions	P16297, Q3TZT2	Gene names	Il2rb
Domain Architecture
Description	Interleukin-2 receptor beta chain precursor (IL-2 receptor) (P70-75) (High affinity IL-2 receptor subunit beta) (CD122 antigen).

AP2A_MOUSE
NC score	0.019067 (rank : 759)	θ value	1.81305 (rank : 346)
Query Neighborhood Hits	554	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	P34056, Q60740, Q60741, Q60742, Q60743, Q62067, Q62068, Q62069, Q91VX0, Q9CRY4	Gene names	Tfap2a, Ap2tf, Tcfap2a
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (Activator protein 2) (AP-2).

KCNN3_HUMAN
NC score	0.018626 (rank : 760)	θ value	2.36792 (rank : 384)
Query Neighborhood Hits	554	Target Neighborhood Hits	216	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

HCN4_HUMAN
NC score	0.018233 (rank : 761)	θ value	8.99809 (rank : 533)
Query Neighborhood Hits	554	Target Neighborhood Hits	303	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

NBR1_MOUSE
NC score	0.018174 (rank : 762)	θ value	4.03905 (rank : 448)
Query Neighborhood Hits	554	Target Neighborhood Hits	116	Shared Neighborhood Hits	15
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

HDGF_MOUSE
NC score	0.018174 (rank : 763)	θ value	4.03905 (rank : 444)
Query Neighborhood Hits	554	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	P51859, Q8BPG7, Q9CYA4, Q9JK87	Gene names	Hdgf, Tdrm1
Domain Architecture
Description	Hepatoma-derived growth factor (HDGF).

AP2A_HUMAN
NC score	0.017744 (rank : 764)	θ value	2.36792 (rank : 374)
Query Neighborhood Hits	554	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P05549, Q13777	Gene names	TFAP2A, AP2TF, TFAP2
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (AP-2 transcription factor) (Activator protein 2) (AP-2).

DYN2_MOUSE
NC score	0.016756 (rank : 765)	θ value	1.38821 (rank : 328)
Query Neighborhood Hits	554	Target Neighborhood Hits	104	Shared Neighborhood Hits	19
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

ATBF1_HUMAN
NC score	0.016647 (rank : 766)	θ value	5.27518 (rank : 462)
Query Neighborhood Hits	554	Target Neighborhood Hits	1547	Shared Neighborhood Hits	95
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

SOX7_HUMAN
NC score	0.016614 (rank : 767)	θ value	4.03905 (rank : 455)
Query Neighborhood Hits	554	Target Neighborhood Hits	140	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BT81	Gene names	SOX7
Domain Architecture
Description	Transcription factor SOX-7.

FYV1_HUMAN
NC score	0.015750 (rank : 768)	θ value	4.03905 (rank : 443)
Query Neighborhood Hits	554	Target Neighborhood Hits	217	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

DYR1B_HUMAN
NC score	0.015219 (rank : 769)	θ value	4.03905 (rank : 439)
Query Neighborhood Hits	554	Target Neighborhood Hits	831	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

PAX9_MOUSE
NC score	0.014405 (rank : 770)	θ value	4.03905 (rank : 449)
Query Neighborhood Hits	554	Target Neighborhood Hits	67	Shared Neighborhood Hits	15
SwissProt Accessions	P47242	Gene names	Pax9, Pax-9
Domain Architecture
Description	Paired box protein Pax-9.

SMAD5_MOUSE
NC score	0.014016 (rank : 771)	θ value	1.38821 (rank : 338)
Query Neighborhood Hits	554	Target Neighborhood Hits	74	Shared Neighborhood Hits	22
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

OST4_HUMAN
NC score	0.013918 (rank : 772)	θ value	3.0926 (rank : 411)
Query Neighborhood Hits	554	Target Neighborhood Hits	95	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y661, Q5QI42, Q8NDC2	Gene names	HS3ST4, 3OST4
Domain Architecture	No domain graphic available
Description	Heparan sulfate glucosamine 3-O-sulfotransferase 4 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4) (Heparan sulfate 3-O-sulfotransferase 4) (h3-OST-4).

PEX19_HUMAN
NC score	0.013731 (rank : 773)	θ value	6.88961 (rank : 501)
Query Neighborhood Hits	554	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	P40855, Q8NI97	Gene names	PEX19, HK33, PXF
Domain Architecture
Description	Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) (33 kDa housekeeping protein).

MYRIP_HUMAN
NC score	0.013537 (rank : 774)	θ value	6.88961 (rank : 496)
Query Neighborhood Hits	554	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

FIGN_HUMAN
NC score	0.013467 (rank : 775)	θ value	6.88961 (rank : 486)
Query Neighborhood Hits	554	Target Neighborhood Hits	176	Shared Neighborhood Hits	30
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

PAX9_HUMAN
NC score	0.012907 (rank : 776)	θ value	6.88961 (rank : 499)
Query Neighborhood Hits	554	Target Neighborhood Hits	92	Shared Neighborhood Hits	22
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

TEAD2_MOUSE
NC score	0.012878 (rank : 777)	θ value	1.81305 (rank : 369)
Query Neighborhood Hits	554	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P48301, Q62297	Gene names	Tead2, Etdf, Etf, Tef4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) (Embryonic TEA domain-containing factor) (ETF) (ETEF-1).

FIGN_MOUSE
NC score	0.012629 (rank : 778)	θ value	3.0926 (rank : 401)
Query Neighborhood Hits	554	Target Neighborhood Hits	165	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

PCD15_MOUSE
NC score	0.012374 (rank : 779)	θ value	0.365318 (rank : 247)
Query Neighborhood Hits	554	Target Neighborhood Hits	262	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PJ1	Gene names	Pcdh15
Domain Architecture
Description	Protocadherin-15 precursor.

KCNN3_MOUSE
NC score	0.012147 (rank : 780)	θ value	8.99809 (rank : 536)
Query Neighborhood Hits	554	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

PGCB_HUMAN
NC score	0.011587 (rank : 781)	θ value	1.06291 (rank : 318)
Query Neighborhood Hits	554	Target Neighborhood Hits	478	Shared Neighborhood Hits	32
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

IGHD_HUMAN
NC score	0.011582 (rank : 782)	θ value	2.36792 (rank : 383)
Query Neighborhood Hits	554	Target Neighborhood Hits	194	Shared Neighborhood Hits	11
SwissProt Accessions	P01880	Gene names	IGHD
Domain Architecture	No domain graphic available
Description	Ig delta chain C region.

INP4B_HUMAN
NC score	0.011437 (rank : 783)	θ value	3.0926 (rank : 405)
Query Neighborhood Hits	554	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	O15327, Q6IN59, Q6PJB4	Gene names	INPP4B
Domain Architecture	No domain graphic available
Description	Type II inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type II).

KCNC3_HUMAN
NC score	0.010788 (rank : 784)	θ value	4.03905 (rank : 445)
Query Neighborhood Hits	554	Target Neighborhood Hits	256	Shared Neighborhood Hits	47
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TEAD2_HUMAN
NC score	0.010061 (rank : 785)	θ value	8.99809 (rank : 549)
Query Neighborhood Hits	554	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q15562, Q96IG3	Gene names	TEAD2, TEF4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2).

ATRIP_MOUSE
NC score	0.009976 (rank : 786)	θ value	8.99809 (rank : 521)
Query Neighborhood Hits	554	Target Neighborhood Hits	248	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BMG1	Gene names	Atrip
Domain Architecture	No domain graphic available
Description	ATR-interacting protein (ATM and Rad3-related-interacting protein).

RBP2_HUMAN
NC score	0.009912 (rank : 787)	θ value	8.99809 (rank : 544)
Query Neighborhood Hits	554	Target Neighborhood Hits	249	Shared Neighborhood Hits	33
SwissProt Accessions	P49792, Q13074, Q15280, Q53TE2, Q59FH7	Gene names	RANBP2, NUP358
Domain Architecture
Description	Ran-binding protein 2 (RanBP2) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (358 kDa nucleoporin) (P270).

FOXJ3_HUMAN
NC score	0.009810 (rank : 788)	θ value	2.36792 (rank : 380)
Query Neighborhood Hits	554	Target Neighborhood Hits	177	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

CAC1A_MOUSE
NC score	0.009758 (rank : 789)	θ value	8.99809 (rank : 522)
Query Neighborhood Hits	554	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

K1024_MOUSE
NC score	0.009757 (rank : 790)	θ value	6.88961 (rank : 492)
Query Neighborhood Hits	554	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3V7, Q69ZS9	Gene names	Kiaa1024
Domain Architecture
Description	UPF0258 protein KIAA1024 (Protein DD1).

KI13B_HUMAN
NC score	0.008686 (rank : 791)	θ value	5.27518 (rank : 469)
Query Neighborhood Hits	554	Target Neighborhood Hits	492	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

DVL1L_HUMAN
NC score	0.008029 (rank : 792)	θ value	5.27518 (rank : 468)
Query Neighborhood Hits	554	Target Neighborhood Hits	146	Shared Neighborhood Hits	13
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

CT075_HUMAN
NC score	0.008007 (rank : 793)	θ value	5.27518 (rank : 467)
Query Neighborhood Hits	554	Target Neighborhood Hits	387	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

NALP1_HUMAN
NC score	0.007615 (rank : 794)	θ value	3.0926 (rank : 408)
Query Neighborhood Hits	554	Target Neighborhood Hits	138	Shared Neighborhood Hits	18
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

RN165_HUMAN
NC score	0.007579 (rank : 795)	θ value	6.88961 (rank : 503)
Query Neighborhood Hits	554	Target Neighborhood Hits	151	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

PKD2_MOUSE
NC score	0.007351 (rank : 796)	θ value	4.03905 (rank : 452)
Query Neighborhood Hits	554	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

ZEP2_MOUSE
NC score	0.006708 (rank : 797)	θ value	5.27518 (rank : 477)
Query Neighborhood Hits	554	Target Neighborhood Hits	964	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

PARP9_HUMAN
NC score	0.006371 (rank : 798)	θ value	6.88961 (rank : 498)
Query Neighborhood Hits	554	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IXQ6, Q8TCP3, Q9BZL8, Q9BZL9	Gene names	PARP9, BAL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 9 (EC 2.4.2.30) (PARP-9) (B aggressive lymphoma protein).

TOPRS_MOUSE
NC score	0.006272 (rank : 799)	θ value	6.88961 (rank : 510)
Query Neighborhood Hits	554	Target Neighborhood Hits	263	Shared Neighborhood Hits	7
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

PTPR2_HUMAN
NC score	0.006198 (rank : 800)	θ value	8.99809 (rank : 543)
Query Neighborhood Hits	554	Target Neighborhood Hits	103	Shared Neighborhood Hits	6
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

SI1L2_MOUSE
NC score	0.005185 (rank : 801)	θ value	8.99809 (rank : 547)
Query Neighborhood Hits	554	Target Neighborhood Hits	124	Shared Neighborhood Hits	8
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

NR4A3_MOUSE
NC score	0.004864 (rank : 802)	θ value	3.0926 (rank : 410)
Query Neighborhood Hits	554	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NOTC1_HUMAN
NC score	0.004559 (rank : 803)	θ value	6.88961 (rank : 497)
Query Neighborhood Hits	554	Target Neighborhood Hits	906	Shared Neighborhood Hits	36
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

SSH2_MOUSE
NC score	0.004493 (rank : 804)	θ value	5.27518 (rank : 476)
Query Neighborhood Hits	554	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

ACRO_HUMAN
NC score	0.004203 (rank : 805)	θ value	6.88961 (rank : 479)
Query Neighborhood Hits	554	Target Neighborhood Hits	291	Shared Neighborhood Hits	51
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

RX_HUMAN
NC score	0.003746 (rank : 806)	θ value	6.88961 (rank : 504)
Query Neighborhood Hits	554	Target Neighborhood Hits	423	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y2V3	Gene names	RAX, RX
Domain Architecture
Description	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein).

GP153_MOUSE
NC score	0.003702 (rank : 807)	θ value	8.99809 (rank : 531)
Query Neighborhood Hits	554	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K0Z9, Q80T37, Q8CFK0	Gene names	Gpr153, Pgr1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

ST18_HUMAN
NC score	0.002286 (rank : 808)	θ value	8.99809 (rank : 548)
Query Neighborhood Hits	554	Target Neighborhood Hits	252	Shared Neighborhood Hits	6
SwissProt Accessions	O60284	Gene names	ST18, KIAA0535, ZNF387
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18 (Zinc finger protein 387).

DDX27_MOUSE
NC score	0.002120 (rank : 809)	θ value	4.03905 (rank : 438)
Query Neighborhood Hits	554	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_HUMAN
NC score	0.001975 (rank : 810)	θ value	4.03905 (rank : 437)
Query Neighborhood Hits	554	Target Neighborhood Hits	197	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DSCAM_HUMAN
NC score	0.001622 (rank : 811)	θ value	6.88961 (rank : 483)
Query Neighborhood Hits	554	Target Neighborhood Hits	524	Shared Neighborhood Hits	11
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

SP7_MOUSE
NC score	0.001233 (rank : 812)	θ value	0.0736092 (rank : 175)
Query Neighborhood Hits	554	Target Neighborhood Hits	756	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VI67, Q8C5R3, Q8C6A7	Gene names	Sp7, Osx
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix) (C22).

NR4A1_MOUSE
NC score	0.001176 (rank : 813)	θ value	5.27518 (rank : 472)
Query Neighborhood Hits	554	Target Neighborhood Hits	128	Shared Neighborhood Hits	6
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

WWP1_MOUSE
NC score	0.001107 (rank : 814)	θ value	8.99809 (rank : 552)
Query Neighborhood Hits	554	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

LAMA4_MOUSE
NC score	0.000994 (rank : 815)	θ value	8.99809 (rank : 537)
Query Neighborhood Hits	554	Target Neighborhood Hits	584	Shared Neighborhood Hits	11
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

EGR2_MOUSE
NC score	-0.000053 (rank : 816)	θ value	0.163984 (rank : 204)
Query Neighborhood Hits	554	Target Neighborhood Hits	745	Shared Neighborhood Hits	25
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

IPF1_HUMAN
NC score	-0.001341 (rank : 817)	θ value	6.88961 (rank : 490)
Query Neighborhood Hits	554	Target Neighborhood Hits	330	Shared Neighborhood Hits	12
SwissProt Accessions	P52945, O60594	Gene names	IPF1, PDX1
Domain Architecture
Description	Insulin promoter factor 1 (IPF-1) (Pancreas/duodenum homeobox 1) (PDX- 1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) (Insulin upstream factor 1) (IUF-1) (Glucose- sensitive factor) (GSF).

SP7_HUMAN
NC score	-0.003197 (rank : 818)	θ value	4.03905 (rank : 456)
Query Neighborhood Hits	554	Target Neighborhood Hits	734	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDD2	Gene names	SP7, OSX
Domain Architecture	No domain graphic available
Description	Transcription factor Sp7 (Zinc finger protein osterix).

ZN653_MOUSE
NC score	-0.007611 (rank : 819)	θ value	4.03905 (rank : 461)
Query Neighborhood Hits	554	Target Neighborhood Hits	744	Shared Neighborhood Hits	14
SwissProt Accessions	Q6YND2, Q8BHT8, Q8CI02	Gene names	Znf653, Zfp653, Zip67
Domain Architecture	No domain graphic available
Description	Zinc finger protein 653 (67 kDa zinc finger protein) (Zinc finger protein Zip67).