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Network neighborhood for query Sequence : FGD2_HUMAN

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FGD2_HUMAN
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	151	Target Neighborhood Hits	151	Shared Neighborhood Hits	151
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	0 (rank : 2)	NC score	0.993261 (rank : 2)
Query Neighborhood Hits	151	Target Neighborhood Hits	163	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_HUMAN
θ value	5.36813e-170 (rank : 3)	NC score	0.975492 (rank : 4)
Query Neighborhood Hits	151	Target Neighborhood Hits	219	Shared Neighborhood Hits	127
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	3.47952e-169 (rank : 4)	NC score	0.976478 (rank : 3)
Query Neighborhood Hits	151	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
θ value	1.12192e-159 (rank : 5)	NC score	0.957374 (rank : 6)
Query Neighborhood Hits	151	Target Neighborhood Hits	367	Shared Neighborhood Hits	128
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	3.6091e-158 (rank : 6)	NC score	0.956116 (rank : 7)
Query Neighborhood Hits	151	Target Neighborhood Hits	387	Shared Neighborhood Hits	127
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
θ value	2.06368e-129 (rank : 7)	NC score	0.958998 (rank : 5)
Query Neighborhood Hits	151	Target Neighborhood Hits	249	Shared Neighborhood Hits	115
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	7.10925e-122 (rank : 8)	NC score	0.955435 (rank : 8)
Query Neighborhood Hits	151	Target Neighborhood Hits	257	Shared Neighborhood Hits	126
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD6_HUMAN
θ value	1.11217e-74 (rank : 9)	NC score	0.903855 (rank : 10)
Query Neighborhood Hits	151	Target Neighborhood Hits	237	Shared Neighborhood Hits	115
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	3.95564e-72 (rank : 10)	NC score	0.905543 (rank : 9)
Query Neighborhood Hits	151	Target Neighborhood Hits	282	Shared Neighborhood Hits	115
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_HUMAN
θ value	2.75849e-49 (rank : 11)	NC score	0.829453 (rank : 11)
Query Neighborhood Hits	151	Target Neighborhood Hits	235	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	5.38352e-45 (rank : 12)	NC score	0.819707 (rank : 12)
Query Neighborhood Hits	151	Target Neighborhood Hits	170	Shared Neighborhood Hits	100
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_MOUSE
θ value	1.85889e-29 (rank : 13)	NC score	0.569556 (rank : 36)
Query Neighborhood Hits	151	Target Neighborhood Hits	209	Shared Neighborhood Hits	87
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	1.12775e-26 (rank : 14)	NC score	0.521100 (rank : 49)
Query Neighborhood Hits	151	Target Neighborhood Hits	241	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PREX1_HUMAN
θ value	2.35151e-24 (rank : 15)	NC score	0.733524 (rank : 13)
Query Neighborhood Hits	151	Target Neighborhood Hits	177	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FARP2_HUMAN
θ value	2.59989e-23 (rank : 16)	NC score	0.548710 (rank : 42)
Query Neighborhood Hits	151	Target Neighborhood Hits	240	Shared Neighborhood Hits	82
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG5_HUMAN
θ value	2.13179e-17 (rank : 17)	NC score	0.658310 (rank : 17)
Query Neighborhood Hits	151	Target Neighborhood Hits	172	Shared Neighborhood Hits	71
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG4_HUMAN
θ value	2.7842e-17 (rank : 18)	NC score	0.643692 (rank : 21)
Query Neighborhood Hits	151	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN1_HUMAN
θ value	3.63628e-17 (rank : 19)	NC score	0.399869 (rank : 78)
Query Neighborhood Hits	151	Target Neighborhood Hits	1757	Shared Neighborhood Hits	87
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

PKHF2_MOUSE
θ value	3.63628e-17 (rank : 20)	NC score	0.653246 (rank : 19)
Query Neighborhood Hits	151	Target Neighborhood Hits	77	Shared Neighborhood Hits	63
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
θ value	8.10077e-17 (rank : 21)	NC score	0.653078 (rank : 20)
Query Neighborhood Hits	151	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ITSN1_MOUSE
θ value	1.80466e-16 (rank : 22)	NC score	0.398691 (rank : 79)
Query Neighborhood Hits	151	Target Neighborhood Hits	1669	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DUET_HUMAN
θ value	3.07829e-16 (rank : 23)	NC score	0.223049 (rank : 104)
Query Neighborhood Hits	151	Target Neighborhood Hits	1220	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_MOUSE
θ value	8.95645e-16 (rank : 24)	NC score	0.716632 (rank : 14)
Query Neighborhood Hits	151	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NGEF_MOUSE
θ value	1.99529e-15 (rank : 25)	NC score	0.627051 (rank : 26)
Query Neighborhood Hits	151	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ITSN2_HUMAN
θ value	2.60593e-15 (rank : 26)	NC score	0.429530 (rank : 69)
Query Neighborhood Hits	151	Target Neighborhood Hits	1173	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NGEF_HUMAN
θ value	2.60593e-15 (rank : 27)	NC score	0.639230 (rank : 23)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHF1_HUMAN
θ value	2.60593e-15 (rank : 28)	NC score	0.642134 (rank : 22)
Query Neighborhood Hits	151	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

TRIO_HUMAN
θ value	2.60593e-15 (rank : 29)	NC score	0.215053 (rank : 105)
Query Neighborhood Hits	151	Target Neighborhood Hits	1580	Shared Neighborhood Hits	83
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHF1_MOUSE
θ value	3.40345e-15 (rank : 30)	NC score	0.638950 (rank : 24)
Query Neighborhood Hits	151	Target Neighborhood Hits	80	Shared Neighborhood Hits	58
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ECT2_HUMAN
θ value	7.58209e-15 (rank : 31)	NC score	0.702807 (rank : 15)
Query Neighborhood Hits	151	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ZFY28_HUMAN
θ value	2.20605e-14 (rank : 32)	NC score	0.533203 (rank : 46)
Query Neighborhood Hits	151	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ARHG3_MOUSE
θ value	1.09485e-13 (rank : 33)	NC score	0.563800 (rank : 39)
Query Neighborhood Hits	151	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	1.09485e-13 (rank : 34)	NC score	0.655914 (rank : 18)
Query Neighborhood Hits	151	Target Neighborhood Hits	185	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

GNRP_MOUSE
θ value	1.09485e-13 (rank : 35)	NC score	0.518647 (rank : 50)
Query Neighborhood Hits	151	Target Neighborhood Hits	191	Shared Neighborhood Hits	72
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
θ value	1.86753e-13 (rank : 36)	NC score	0.489449 (rank : 60)
Query Neighborhood Hits	151	Target Neighborhood Hits	239	Shared Neighborhood Hits	70
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
θ value	3.18553e-13 (rank : 37)	NC score	0.425838 (rank : 72)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

VAV_HUMAN
θ value	4.16044e-13 (rank : 38)	NC score	0.441729 (rank : 65)
Query Neighborhood Hits	151	Target Neighborhood Hits	452	Shared Neighborhood Hits	71
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	4.16044e-13 (rank : 39)	NC score	0.448922 (rank : 64)
Query Neighborhood Hits	151	Target Neighborhood Hits	430	Shared Neighborhood Hits	71
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG3_HUMAN
θ value	5.43371e-13 (rank : 40)	NC score	0.562312 (rank : 40)
Query Neighborhood Hits	151	Target Neighborhood Hits	82	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

MCF2L_MOUSE
θ value	5.43371e-13 (rank : 41)	NC score	0.571470 (rank : 35)
Query Neighborhood Hits	151	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG9_HUMAN
θ value	7.09661e-13 (rank : 42)	NC score	0.622880 (rank : 27)
Query Neighborhood Hits	151	Target Neighborhood Hits	235	Shared Neighborhood Hits	73
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ITSN2_MOUSE
θ value	7.09661e-13 (rank : 43)	NC score	0.407133 (rank : 77)
Query Neighborhood Hits	151	Target Neighborhood Hits	1371	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG9_MOUSE
θ value	9.26847e-13 (rank : 44)	NC score	0.621343 (rank : 28)
Query Neighborhood Hits	151	Target Neighborhood Hits	234	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

BCR_HUMAN
θ value	9.26847e-13 (rank : 45)	NC score	0.428753 (rank : 70)
Query Neighborhood Hits	151	Target Neighborhood Hits	204	Shared Neighborhood Hits	63
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

MCF2_HUMAN
θ value	1.58096e-12 (rank : 46)	NC score	0.604956 (rank : 30)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG7_HUMAN
θ value	2.0648e-12 (rank : 47)	NC score	0.490799 (rank : 59)
Query Neighborhood Hits	151	Target Neighborhood Hits	347	Shared Neighborhood Hits	76
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ZFYV9_HUMAN
θ value	2.0648e-12 (rank : 48)	NC score	0.508113 (rank : 54)
Query Neighborhood Hits	151	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

HAPIP_HUMAN
θ value	3.52202e-12 (rank : 49)	NC score	0.538810 (rank : 44)
Query Neighborhood Hits	151	Target Neighborhood Hits	350	Shared Neighborhood Hits	80
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHGA_MOUSE
θ value	4.59992e-12 (rank : 50)	NC score	0.599726 (rank : 32)
Query Neighborhood Hits	151	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PKHG1_HUMAN
θ value	6.00763e-12 (rank : 51)	NC score	0.681396 (rank : 16)
Query Neighborhood Hits	151	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_HUMAN
θ value	1.33837e-11 (rank : 52)	NC score	0.604044 (rank : 31)
Query Neighborhood Hits	151	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGF_HUMAN
θ value	1.74796e-11 (rank : 53)	NC score	0.588295 (rank : 33)
Query Neighborhood Hits	151	Target Neighborhood Hits	214	Shared Neighborhood Hits	66
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG1_MOUSE
θ value	2.98157e-11 (rank : 54)	NC score	0.530007 (rank : 47)
Query Neighborhood Hits	151	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG1_HUMAN
θ value	5.08577e-11 (rank : 55)	NC score	0.554124 (rank : 41)
Query Neighborhood Hits	151	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ZFY16_HUMAN
θ value	5.08577e-11 (rank : 56)	NC score	0.483962 (rank : 61)
Query Neighborhood Hits	151	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	5.08577e-11 (rank : 57)	NC score	0.492522 (rank : 58)
Query Neighborhood Hits	151	Target Neighborhood Hits	108	Shared Neighborhood Hits	50
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ARHG7_MOUSE
θ value	8.67504e-11 (rank : 58)	NC score	0.471850 (rank : 63)
Query Neighborhood Hits	151	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	1.47974e-10 (rank : 59)	NC score	0.546924 (rank : 43)
Query Neighborhood Hits	151	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
θ value	5.62301e-10 (rank : 60)	NC score	0.632093 (rank : 25)
Query Neighborhood Hits	151	Target Neighborhood Hits	129	Shared Neighborhood Hits	69
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

RUFY2_HUMAN
θ value	5.62301e-10 (rank : 61)	NC score	0.236368 (rank : 103)
Query Neighborhood Hits	151	Target Neighborhood Hits	1208	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

LBC_HUMAN
θ value	7.34386e-10 (rank : 62)	NC score	0.536571 (rank : 45)
Query Neighborhood Hits	151	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

RUFY2_MOUSE
θ value	7.34386e-10 (rank : 63)	NC score	0.286872 (rank : 96)
Query Neighborhood Hits	151	Target Neighborhood Hits	820	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

EEA1_HUMAN
θ value	1.63604e-09 (rank : 64)	NC score	0.173832 (rank : 112)
Query Neighborhood Hits	151	Target Neighborhood Hits	1796	Shared Neighborhood Hits	70
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TIAM1_MOUSE
θ value	2.13673e-09 (rank : 65)	NC score	0.571733 (rank : 34)
Query Neighborhood Hits	151	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGC_MOUSE
θ value	2.79066e-09 (rank : 66)	NC score	0.499676 (rank : 57)
Query Neighborhood Hits	151	Target Neighborhood Hits	344	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TIAM1_HUMAN
θ value	3.64472e-09 (rank : 67)	NC score	0.568587 (rank : 37)
Query Neighborhood Hits	151	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

EEA1_MOUSE
θ value	4.76016e-09 (rank : 68)	NC score	0.188565 (rank : 109)
Query Neighborhood Hits	151	Target Neighborhood Hits	1637	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RUFY1_HUMAN
θ value	4.76016e-09 (rank : 69)	NC score	0.279933 (rank : 99)
Query Neighborhood Hits	151	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY3_HUMAN
θ value	6.21693e-09 (rank : 70)	NC score	0.287898 (rank : 95)
Query Neighborhood Hits	151	Target Neighborhood Hits	348	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	6.21693e-09 (rank : 71)	NC score	0.288165 (rank : 94)
Query Neighborhood Hits	151	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

ARHGG_MOUSE
θ value	8.11959e-09 (rank : 72)	NC score	0.613627 (rank : 29)
Query Neighborhood Hits	151	Target Neighborhood Hits	152	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

OBSCN_HUMAN
θ value	8.11959e-09 (rank : 73)	NC score	0.104199 (rank : 124)
Query Neighborhood Hits	151	Target Neighborhood Hits	1931	Shared Neighborhood Hits	60
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ZFY21_HUMAN
θ value	8.11959e-09 (rank : 74)	NC score	0.502744 (rank : 55)
Query Neighborhood Hits	151	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHGC_HUMAN
θ value	1.06045e-08 (rank : 75)	NC score	0.501134 (rank : 56)
Query Neighborhood Hits	151	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_MOUSE
θ value	1.38499e-08 (rank : 76)	NC score	0.567497 (rank : 38)
Query Neighborhood Hits	151	Target Neighborhood Hits	120	Shared Neighborhood Hits	63
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG6_HUMAN
θ value	1.38499e-08 (rank : 77)	NC score	0.414543 (rank : 76)
Query Neighborhood Hits	151	Target Neighborhood Hits	376	Shared Neighborhood Hits	64
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

RUFY1_MOUSE
θ value	1.38499e-08 (rank : 78)	NC score	0.284840 (rank : 97)
Query Neighborhood Hits	151	Target Neighborhood Hits	765	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ZFY21_MOUSE
θ value	1.80886e-08 (rank : 79)	NC score	0.508722 (rank : 53)
Query Neighborhood Hits	151	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHG2_HUMAN
θ value	4.0297e-08 (rank : 80)	NC score	0.514917 (rank : 51)
Query Neighborhood Hits	151	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGB_HUMAN
θ value	4.0297e-08 (rank : 81)	NC score	0.525594 (rank : 48)
Query Neighborhood Hits	151	Target Neighborhood Hits	375	Shared Neighborhood Hits	71
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SOS2_HUMAN
θ value	8.97725e-08 (rank : 82)	NC score	0.307398 (rank : 91)
Query Neighborhood Hits	151	Target Neighborhood Hits	193	Shared Neighborhood Hits	41
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

HGS_HUMAN
θ value	1.53129e-07 (rank : 83)	NC score	0.387440 (rank : 80)
Query Neighborhood Hits	151	Target Neighborhood Hits	517	Shared Neighborhood Hits	56
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ARHG6_MOUSE
θ value	1.99992e-07 (rank : 84)	NC score	0.384627 (rank : 82)
Query Neighborhood Hits	151	Target Neighborhood Hits	394	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

HGS_MOUSE
θ value	1.99992e-07 (rank : 85)	NC score	0.386764 (rank : 81)
Query Neighborhood Hits	151	Target Neighborhood Hits	589	Shared Neighborhood Hits	55
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

PKHG4_HUMAN
θ value	2.61198e-07 (rank : 86)	NC score	0.510695 (rank : 52)
Query Neighborhood Hits	151	Target Neighborhood Hits	200	Shared Neighborhood Hits	58
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RGNEF_MOUSE
θ value	3.41135e-07 (rank : 87)	NC score	0.418295 (rank : 75)
Query Neighborhood Hits	151	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

VAV3_HUMAN
θ value	1.29631e-06 (rank : 88)	NC score	0.425019 (rank : 73)
Query Neighborhood Hits	151	Target Neighborhood Hits	398	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ANFY1_MOUSE
θ value	2.21117e-06 (rank : 89)	NC score	0.186005 (rank : 110)
Query Neighborhood Hits	151	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
θ value	2.88788e-06 (rank : 90)	NC score	0.185829 (rank : 111)
Query Neighborhood Hits	151	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

DNMBP_HUMAN
θ value	2.88788e-06 (rank : 91)	NC score	0.421868 (rank : 74)
Query Neighborhood Hits	151	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV3_MOUSE
θ value	3.77169e-06 (rank : 92)	NC score	0.427410 (rank : 71)
Query Neighborhood Hits	151	Target Neighborhood Hits	404	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FYV1_HUMAN
θ value	4.92598e-06 (rank : 93)	NC score	0.332409 (rank : 87)
Query Neighborhood Hits	151	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	4.92598e-06 (rank : 94)	NC score	0.329832 (rank : 88)
Query Neighborhood Hits	151	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

MTMR3_HUMAN
θ value	4.92598e-06 (rank : 95)	NC score	0.269065 (rank : 101)
Query Neighborhood Hits	151	Target Neighborhood Hits	163	Shared Neighborhood Hits	52
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

VAV2_HUMAN
θ value	8.40245e-06 (rank : 96)	NC score	0.431069 (rank : 68)
Query Neighborhood Hits	151	Target Neighborhood Hits	453	Shared Neighborhood Hits	76
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	1.09739e-05 (rank : 97)	NC score	0.435757 (rank : 67)
Query Neighborhood Hits	151	Target Neighborhood Hits	456	Shared Neighborhood Hits	75
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ZFYV1_HUMAN
θ value	1.09739e-05 (rank : 98)	NC score	0.378255 (rank : 83)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

DNMBP_MOUSE
θ value	1.43324e-05 (rank : 99)	NC score	0.438714 (rank : 66)
Query Neighborhood Hits	151	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SOS1_HUMAN
θ value	1.43324e-05 (rank : 100)	NC score	0.302293 (rank : 92)
Query Neighborhood Hits	151	Target Neighborhood Hits	274	Shared Neighborhood Hits	39
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ZFYV1_MOUSE
θ value	1.43324e-05 (rank : 101)	NC score	0.374588 (rank : 84)
Query Neighborhood Hits	151	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

WDFY1_HUMAN
θ value	3.19293e-05 (rank : 102)	NC score	0.291535 (rank : 93)
Query Neighborhood Hits	151	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

SOS1_MOUSE
θ value	7.1131e-05 (rank : 103)	NC score	0.283721 (rank : 98)
Query Neighborhood Hits	151	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

FYCO1_HUMAN
θ value	0.00020696 (rank : 104)	NC score	0.188778 (rank : 108)
Query Neighborhood Hits	151	Target Neighborhood Hits	1149	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

RBNS5_HUMAN
θ value	0.00020696 (rank : 105)	NC score	0.371517 (rank : 85)
Query Neighborhood Hits	151	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	0.00020696 (rank : 106)	NC score	0.364088 (rank : 86)
Query Neighborhood Hits	151	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

WDFY2_HUMAN
θ value	0.000602161 (rank : 107)	NC score	0.267691 (rank : 102)
Query Neighborhood Hits	151	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.000602161 (rank : 108)	NC score	0.269514 (rank : 100)
Query Neighborhood Hits	151	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FYCO1_MOUSE
θ value	0.00665767 (rank : 109)	NC score	0.173536 (rank : 113)
Query Neighborhood Hits	151	Target Neighborhood Hits	1059	Shared Neighborhood Hits	66
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ALS2_MOUSE
θ value	0.0113563 (rank : 110)	NC score	0.140296 (rank : 116)
Query Neighborhood Hits	151	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

MYRIP_MOUSE
θ value	0.0330416 (rank : 111)	NC score	0.092710 (rank : 133)
Query Neighborhood Hits	151	Target Neighborhood Hits	207	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

ZFY19_HUMAN
θ value	0.0330416 (rank : 112)	NC score	0.326543 (rank : 89)
Query Neighborhood Hits	151	Target Neighborhood Hits	206	Shared Neighborhood Hits	49
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	0.0330416 (rank : 113)	NC score	0.319771 (rank : 90)
Query Neighborhood Hits	151	Target Neighborhood Hits	143	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

MELPH_MOUSE
θ value	0.0431538 (rank : 114)	NC score	0.096262 (rank : 129)
Query Neighborhood Hits	151	Target Neighborhood Hits	112	Shared Neighborhood Hits	17
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

MYRIP_HUMAN
θ value	0.125558 (rank : 115)	NC score	0.076851 (rank : 158)
Query Neighborhood Hits	151	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

ALS2_HUMAN
θ value	0.279714 (rank : 116)	NC score	0.120354 (rank : 118)
Query Neighborhood Hits	151	Target Neighborhood Hits	121	Shared Neighborhood Hits	24
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SYTL4_HUMAN
θ value	0.279714 (rank : 117)	NC score	0.048621 (rank : 254)
Query Neighborhood Hits	151	Target Neighborhood Hits	138	Shared Neighborhood Hits	21
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

CENB5_HUMAN
θ value	0.365318 (rank : 118)	NC score	0.039875 (rank : 257)
Query Neighborhood Hits	151	Target Neighborhood Hits	395	Shared Neighborhood Hits	26
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CYH2_HUMAN
θ value	0.47712 (rank : 119)	NC score	0.055542 (rank : 223)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	26
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.47712 (rank : 120)	NC score	0.055476 (rank : 224)
Query Neighborhood Hits	151	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.074461 (rank : 162)
Query Neighborhood Hits	151	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

DGKK_HUMAN
θ value	0.47712 (rank : 122)	NC score	0.044347 (rank : 256)
Query Neighborhood Hits	151	Target Neighborhood Hits	378	Shared Neighborhood Hits	17
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

MELPH_HUMAN
θ value	0.62314 (rank : 123)	NC score	0.083144 (rank : 147)
Query Neighborhood Hits	151	Target Neighborhood Hits	145	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

GCH1_MOUSE
θ value	1.38821 (rank : 124)	NC score	0.018114 (rank : 263)
Query Neighborhood Hits	151	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q05915	Gene names	Gch1, Gch
Domain Architecture
Description	GTP cyclohydrolase I precursor (EC 3.5.4.16) (GTP-CH-I).

PKHA6_HUMAN
θ value	1.38821 (rank : 125)	NC score	0.150855 (rank : 114)
Query Neighborhood Hits	151	Target Neighborhood Hits	556	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

BARH2_HUMAN
θ value	1.81305 (rank : 126)	NC score	0.000183 (rank : 274)
Query Neighborhood Hits	151	Target Neighborhood Hits	419	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NY43, Q7Z4N7	Gene names	BARHL2
Domain Architecture
Description	BarH-like 2 homeobox protein.

CYH1_HUMAN
θ value	1.81305 (rank : 127)	NC score	0.059197 (rank : 206)
Query Neighborhood Hits	151	Target Neighborhood Hits	184	Shared Neighborhood Hits	29
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	1.81305 (rank : 128)	NC score	0.056518 (rank : 215)
Query Neighborhood Hits	151	Target Neighborhood Hits	176	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH4_MOUSE
θ value	1.81305 (rank : 129)	NC score	0.065606 (rank : 187)
Query Neighborhood Hits	151	Target Neighborhood Hits	134	Shared Neighborhood Hits	26
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CP250_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.036875 (rank : 258)
Query Neighborhood Hits	151	Target Neighborhood Hits	1805	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CYH4_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.060532 (rank : 201)
Query Neighborhood Hits	151	Target Neighborhood Hits	135	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

DGKD_HUMAN
θ value	2.36792 (rank : 132)	NC score	0.052913 (rank : 238)
Query Neighborhood Hits	151	Target Neighborhood Hits	231	Shared Neighborhood Hits	19
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PKHA6_MOUSE
θ value	2.36792 (rank : 133)	NC score	0.147923 (rank : 115)
Query Neighborhood Hits	151	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SYNE1_HUMAN
θ value	2.36792 (rank : 134)	NC score	0.034928 (rank : 260)
Query Neighborhood Hits	151	Target Neighborhood Hits	1484	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ARMX1_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.005975 (rank : 270)
Query Neighborhood Hits	151	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P291, Q53HK2, Q9H2Q0	Gene names	ARMCX1, ALEX1
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 1 (Protein ALEX1) (ARM protein lost in epithelial cancers on chromosome X 1).

STOX1_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.014670 (rank : 264)
Query Neighborhood Hits	151	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZVD7, Q4F8Q6, Q5I946, Q5I947, Q5I948, Q5VX38, Q5VX39, Q6ZRY3, Q96LR3, Q96LS0	Gene names	STOX1, C10orf24
Domain Architecture	No domain graphic available
Description	Storkhead-box protein 1 (Winged helix domain-containing protein).

TIM_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.014039 (rank : 265)
Query Neighborhood Hits	151	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNS1, O94802, Q86VM1, Q8IWH3	Gene names	TIMELESS, TIM, TIM1, TIMELESS1
Domain Architecture	No domain graphic available
Description	Timeless homolog (hTIM).

CHM4A_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.011188 (rank : 268)
Query Neighborhood Hits	151	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BY43, Q32Q79, Q86SZ8, Q96QJ9, Q9P026	Gene names	CHMP4A, C14orf123, SHAX2
Domain Architecture
Description	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (Vacuolar protein sorting 7-1) (SNF7-1) (hSnf-1) (SNF7 homolog associated with Alix-2).

NHLC1_MOUSE
θ value	4.03905 (rank : 139)	NC score	0.047964 (rank : 255)
Query Neighborhood Hits	151	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

SYTL4_MOUSE
θ value	4.03905 (rank : 140)	NC score	0.035541 (rank : 259)
Query Neighborhood Hits	151	Target Neighborhood Hits	137	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

T2R49_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.000945 (rank : 273)
Query Neighborhood Hits	151	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	P59543, P59549, Q645X9	Gene names	TAS2R49
Domain Architecture
Description	Taste receptor type 2 member 49 (T2R49) (T2R56).

CUTL2_MOUSE
θ value	5.27518 (rank : 142)	NC score	0.010245 (rank : 269)
Query Neighborhood Hits	151	Target Neighborhood Hits	771	Shared Neighborhood Hits	17
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

PKHA1_HUMAN
θ value	5.27518 (rank : 143)	NC score	0.031425 (rank : 262)
Query Neighborhood Hits	151	Target Neighborhood Hits	127	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

SYTL3_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.032102 (rank : 261)
Query Neighborhood Hits	151	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

TBX6_MOUSE
θ value	6.88961 (rank : 145)	NC score	0.001333 (rank : 272)
Query Neighborhood Hits	151	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	P70327	Gene names	Tbx6
Domain Architecture
Description	T-box transcription factor TBX6 (T-box protein 6).

TIM_MOUSE
θ value	6.88961 (rank : 146)	NC score	0.011995 (rank : 266)
Query Neighborhood Hits	151	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1X4, Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7	Gene names	Timeless, Tim1, Timeless1
Domain Architecture	No domain graphic available
Description	Timeless homolog (mTim).

ZFY27_HUMAN
θ value	6.88961 (rank : 147)	NC score	0.191635 (rank : 107)
Query Neighborhood Hits	151	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

CLD23_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.004072 (rank : 271)
Query Neighborhood Hits	151	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B33	Gene names	CLDN23
Domain Architecture
Description	Claudin-23.

DDFL1_MOUSE
θ value	8.99809 (rank : 149)	NC score	0.011639 (rank : 267)
Query Neighborhood Hits	151	Target Neighborhood Hits	324	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

PGCB_MOUSE
θ value	8.99809 (rank : 150)	NC score	-0.001510 (rank : 275)
Query Neighborhood Hits	151	Target Neighborhood Hits	459	Shared Neighborhood Hits	3
SwissProt Accessions	Q61361	Gene names	Bcan
Domain Architecture
Description	Brevican core protein precursor.

ZFY27_MOUSE
θ value	8.99809 (rank : 151)	NC score	0.197358 (rank : 106)
Query Neighborhood Hits	151	Target Neighborhood Hits	53	Shared Neighborhood Hits	42
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

3BP2_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.056541 (rank : 214)
Query Neighborhood Hits	151	Target Neighborhood Hits	296	Shared Neighborhood Hits	23
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.052511 (rank : 240)
Query Neighborhood Hits	151	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.050013 (rank : 253)
Query Neighborhood Hits	151	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

ABI1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.070130 (rank : 175)
Query Neighborhood Hits	151	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.075393 (rank : 159)
Query Neighborhood Hits	151	Target Neighborhood Hits	246	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.077831 (rank : 153)
Query Neighborhood Hits	151	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.077661 (rank : 154)
Query Neighborhood Hits	151	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.067597 (rank : 181)
Query Neighborhood Hits	151	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.066416 (rank : 186)
Query Neighborhood Hits	151	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.069173 (rank : 177)
Query Neighborhood Hits	151	Target Neighborhood Hits	537	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.062284 (rank : 196)
Query Neighborhood Hits	151	Target Neighborhood Hits	496	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.056033 (rank : 217)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.052272 (rank : 241)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG8_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.477544 (rank : 62)
Query Neighborhood Hits	151	Target Neighborhood Hits	79	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ASPP1_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.053097 (rank : 234)
Query Neighborhood Hits	151	Target Neighborhood Hits	1244	Shared Neighborhood Hits	43
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.055148 (rank : 226)
Query Neighborhood Hits	151	Target Neighborhood Hits	554	Shared Neighborhood Hits	25
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.055688 (rank : 221)
Query Neighborhood Hits	151	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.074765 (rank : 161)
Query Neighborhood Hits	151	Target Neighborhood Hits	156	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.060485 (rank : 202)
Query Neighborhood Hits	151	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CD2AP_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.110566 (rank : 121)
Query Neighborhood Hits	151	Target Neighborhood Hits	315	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.109684 (rank : 123)
Query Neighborhood Hits	151	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CJ064_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.052960 (rank : 237)
Query Neighborhood Hits	151	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CNKR1_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.070601 (rank : 174)
Query Neighborhood Hits	151	Target Neighborhood Hits	154	Shared Neighborhood Hits	24
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.054673 (rank : 229)
Query Neighborhood Hits	151	Target Neighborhood Hits	197	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.054900 (rank : 228)
Query Neighborhood Hits	151	Target Neighborhood Hits	197	Shared Neighborhood Hits	21
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.068183 (rank : 178)
Query Neighborhood Hits	151	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.066508 (rank : 185)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.063471 (rank : 194)
Query Neighborhood Hits	151	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.066624 (rank : 184)
Query Neighborhood Hits	151	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.053095 (rank : 235)
Query Neighborhood Hits	151	Target Neighborhood Hits	235	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CYH3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.055420 (rank : 225)
Query Neighborhood Hits	151	Target Neighborhood Hits	137	Shared Neighborhood Hits	22
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DBNL_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.061971 (rank : 198)
Query Neighborhood Hits	151	Target Neighborhood Hits	244	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.059253 (rank : 205)
Query Neighborhood Hits	151	Target Neighborhood Hits	306	Shared Neighborhood Hits	20
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.050570 (rank : 249)
Query Neighborhood Hits	151	Target Neighborhood Hits	599	Shared Neighborhood Hits	34
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.050567 (rank : 250)
Query Neighborhood Hits	151	Target Neighborhood Hits	625	Shared Neighborhood Hits	33
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKH_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.066861 (rank : 182)
Query Neighborhood Hits	151	Target Neighborhood Hits	255	Shared Neighborhood Hits	33
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

E41L3_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.050977 (rank : 246)
Query Neighborhood Hits	151	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.050658 (rank : 247)
Query Neighborhood Hits	151	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.051900 (rank : 244)
Query Neighborhood Hits	151	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.050622 (rank : 248)
Query Neighborhood Hits	151	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EFS_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.058355 (rank : 210)
Query Neighborhood Hits	151	Target Neighborhood Hits	389	Shared Neighborhood Hits	21
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.052515 (rank : 239)
Query Neighborhood Hits	151	Target Neighborhood Hits	432	Shared Neighborhood Hits	27
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRAP2_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.072130 (rank : 168)
Query Neighborhood Hits	151	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.071938 (rank : 170)
Query Neighborhood Hits	151	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.087101 (rank : 141)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.085792 (rank : 144)
Query Neighborhood Hits	151	Target Neighborhood Hits	309	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.078248 (rank : 150)
Query Neighborhood Hits	151	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.078227 (rank : 151)
Query Neighborhood Hits	151	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.063936 (rank : 191)
Query Neighborhood Hits	151	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.073633 (rank : 165)
Query Neighborhood Hits	151	Target Neighborhood Hits	358	Shared Neighborhood Hits	22
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.074179 (rank : 163)
Query Neighborhood Hits	151	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

LASP1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.057486 (rank : 211)
Query Neighborhood Hits	151	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.055857 (rank : 218)
Query Neighborhood Hits	151	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.121101 (rank : 117)
Query Neighborhood Hits	151	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.113102 (rank : 120)
Query Neighborhood Hits	151	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.099693 (rank : 126)
Query Neighborhood Hits	151	Target Neighborhood Hits	229	Shared Neighborhood Hits	26
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.089154 (rank : 138)
Query Neighborhood Hits	151	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.088996 (rank : 139)
Query Neighborhood Hits	151	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.094129 (rank : 132)
Query Neighborhood Hits	151	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.090858 (rank : 135)
Query Neighborhood Hits	151	Target Neighborhood Hits	310	Shared Neighborhood Hits	26
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.063411 (rank : 195)
Query Neighborhood Hits	151	Target Neighborhood Hits	457	Shared Neighborhood Hits	26
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.054082 (rank : 230)
Query Neighborhood Hits	151	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.061192 (rank : 199)
Query Neighborhood Hits	151	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.051992 (rank : 243)
Query Neighborhood Hits	151	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.058541 (rank : 209)
Query Neighborhood Hits	151	Target Neighborhood Hits	267	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSBL9_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.059186 (rank : 207)
Query Neighborhood Hits	151	Target Neighborhood Hits	138	Shared Neighborhood Hits	24
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSTF1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.065479 (rank : 188)
Query Neighborhood Hits	151	Target Neighborhood Hits	466	Shared Neighborhood Hits	25
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.064781 (rank : 190)
Query Neighborhood Hits	151	Target Neighborhood Hits	467	Shared Neighborhood Hits	25
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.053014 (rank : 236)
Query Neighborhood Hits	151	Target Neighborhood Hits	339	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.053657 (rank : 232)
Query Neighborhood Hits	151	Target Neighborhood Hits	382	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PEX13_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.055807 (rank : 220)
Query Neighborhood Hits	151	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.057368 (rank : 212)
Query Neighborhood Hits	151	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.053140 (rank : 233)
Query Neighborhood Hits	151	Target Neighborhood Hits	119	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.060226 (rank : 203)
Query Neighborhood Hits	151	Target Neighborhood Hits	116	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.090702 (rank : 136)
Query Neighborhood Hits	151	Target Neighborhood Hits	283	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.092106 (rank : 134)
Query Neighborhood Hits	151	Target Neighborhood Hits	202	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.096752 (rank : 128)
Query Neighborhood Hits	151	Target Neighborhood Hits	455	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.066683 (rank : 183)
Query Neighborhood Hits	151	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.068086 (rank : 179)
Query Neighborhood Hits	151	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.055001 (rank : 227)
Query Neighborhood Hits	151	Target Neighborhood Hits	280	Shared Neighborhood Hits	16
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.073907 (rank : 164)
Query Neighborhood Hits	151	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.072093 (rank : 169)
Query Neighborhood Hits	151	Target Neighborhood Hits	377	Shared Neighborhood Hits	29
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.050414 (rank : 252)
Query Neighborhood Hits	151	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RFFL_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.052085 (rank : 242)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.060995 (rank : 200)
Query Neighborhood Hits	151	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RHG04_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.058764 (rank : 208)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.050502 (rank : 251)
Query Neighborhood Hits	151	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RNF34_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.055810 (rank : 219)
Query Neighborhood Hits	151	Target Neighborhood Hits	153	Shared Neighborhood Hits	29
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.060190 (rank : 204)
Query Neighborhood Hits	151	Target Neighborhood Hits	160	Shared Neighborhood Hits	32
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RPGF1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.056492 (rank : 216)
Query Neighborhood Hits	151	Target Neighborhood Hits	262	Shared Neighborhood Hits	7
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RUFY3_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.077511 (rank : 156)
Query Neighborhood Hits	151	Target Neighborhood Hits	594	Shared Neighborhood Hits	14
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.078206 (rank : 152)
Query Neighborhood Hits	151	Target Neighborhood Hits	579	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.071392 (rank : 171)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	24
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.067691 (rank : 180)
Query Neighborhood Hits	151	Target Neighborhood Hits	291	Shared Neighborhood Hits	22
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.071334 (rank : 172)
Query Neighborhood Hits	151	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.069347 (rank : 176)
Query Neighborhood Hits	151	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.070911 (rank : 173)
Query Neighborhood Hits	151	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.073007 (rank : 167)
Query Neighborhood Hits	151	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.118877 (rank : 119)
Query Neighborhood Hits	151	Target Neighborhood Hits	341	Shared Neighborhood Hits	27
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.110256 (rank : 122)
Query Neighborhood Hits	151	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.054044 (rank : 231)
Query Neighborhood Hits	151	Target Neighborhood Hits	1041	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.063568 (rank : 192)
Query Neighborhood Hits	151	Target Neighborhood Hits	446	Shared Neighborhood Hits	27
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.055559 (rank : 222)
Query Neighborhood Hits	151	Target Neighborhood Hits	748	Shared Neighborhood Hits	37
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.056833 (rank : 213)
Query Neighborhood Hits	151	Target Neighborhood Hits	675	Shared Neighborhood Hits	34
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.062239 (rank : 197)
Query Neighborhood Hits	151	Target Neighborhood Hits	888	Shared Neighborhood Hits	36
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.099238 (rank : 127)
Query Neighborhood Hits	151	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.100271 (rank : 125)
Query Neighborhood Hits	151	Target Neighborhood Hits	409	Shared Neighborhood Hits	24
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.074929 (rank : 160)
Query Neighborhood Hits	151	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.073353 (rank : 166)
Query Neighborhood Hits	151	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.051368 (rank : 245)
Query Neighborhood Hits	151	Target Neighborhood Hits	390	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.076854 (rank : 157)
Query Neighborhood Hits	151	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.077609 (rank : 155)
Query Neighborhood Hits	151	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.084946 (rank : 145)
Query Neighborhood Hits	151	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.082153 (rank : 148)
Query Neighborhood Hits	151	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.089628 (rank : 137)
Query Neighborhood Hits	151	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.088716 (rank : 140)
Query Neighborhood Hits	151	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.086107 (rank : 143)
Query Neighborhood Hits	151	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.086863 (rank : 142)
Query Neighborhood Hits	151	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SWP70_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.083900 (rank : 146)
Query Neighborhood Hits	151	Target Neighborhood Hits	973	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.080123 (rank : 149)
Query Neighborhood Hits	151	Target Neighborhood Hits	1097	Shared Neighborhood Hits	51
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TCGAP_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.063553 (rank : 193)
Query Neighborhood Hits	151	Target Neighborhood Hits	872	Shared Neighborhood Hits	31
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.065053 (rank : 189)
Query Neighborhood Hits	151	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.095877 (rank : 130)
Query Neighborhood Hits	151	Target Neighborhood Hits	270	Shared Neighborhood Hits	25
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.095326 (rank : 131)
Query Neighborhood Hits	151	Target Neighborhood Hits	286	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

FGD2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	151	Target Neighborhood Hits	151	Shared Neighborhood Hits	151
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
NC score	0.993261 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	151	Target Neighborhood Hits	163	Shared Neighborhood Hits	131
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_MOUSE
NC score	0.976478 (rank : 3)	θ value	3.47952e-169 (rank : 4)
Query Neighborhood Hits	151	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
NC score	0.975492 (rank : 4)	θ value	5.36813e-170 (rank : 3)
Query Neighborhood Hits	151	Target Neighborhood Hits	219	Shared Neighborhood Hits	127
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD3_HUMAN
NC score	0.958998 (rank : 5)	θ value	2.06368e-129 (rank : 7)
Query Neighborhood Hits	151	Target Neighborhood Hits	249	Shared Neighborhood Hits	115
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD1_HUMAN
NC score	0.957374 (rank : 6)	θ value	1.12192e-159 (rank : 5)
Query Neighborhood Hits	151	Target Neighborhood Hits	367	Shared Neighborhood Hits	128
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.956116 (rank : 7)	θ value	3.6091e-158 (rank : 6)
Query Neighborhood Hits	151	Target Neighborhood Hits	387	Shared Neighborhood Hits	127
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_MOUSE
NC score	0.955435 (rank : 8)	θ value	7.10925e-122 (rank : 8)
Query Neighborhood Hits	151	Target Neighborhood Hits	257	Shared Neighborhood Hits	126
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD6_MOUSE
NC score	0.905543 (rank : 9)	θ value	3.95564e-72 (rank : 10)
Query Neighborhood Hits	151	Target Neighborhood Hits	282	Shared Neighborhood Hits	115
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.903855 (rank : 10)	θ value	1.11217e-74 (rank : 9)
Query Neighborhood Hits	151	Target Neighborhood Hits	237	Shared Neighborhood Hits	115
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
NC score	0.829453 (rank : 11)	θ value	2.75849e-49 (rank : 11)
Query Neighborhood Hits	151	Target Neighborhood Hits	235	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.819707 (rank : 12)	θ value	5.38352e-45 (rank : 12)
Query Neighborhood Hits	151	Target Neighborhood Hits	170	Shared Neighborhood Hits	100
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PREX1_HUMAN
NC score	0.733524 (rank : 13)	θ value	2.35151e-24 (rank : 15)
Query Neighborhood Hits	151	Target Neighborhood Hits	177	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_MOUSE
NC score	0.716632 (rank : 14)	θ value	8.95645e-16 (rank : 24)
Query Neighborhood Hits	151	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.702807 (rank : 15)	θ value	7.58209e-15 (rank : 31)
Query Neighborhood Hits	151	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PKHG1_HUMAN
NC score	0.681396 (rank : 16)	θ value	6.00763e-12 (rank : 51)
Query Neighborhood Hits	151	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG5_HUMAN
NC score	0.658310 (rank : 17)	θ value	2.13179e-17 (rank : 17)
Query Neighborhood Hits	151	Target Neighborhood Hits	172	Shared Neighborhood Hits	71
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG4_MOUSE
NC score	0.655914 (rank : 18)	θ value	1.09485e-13 (rank : 34)
Query Neighborhood Hits	151	Target Neighborhood Hits	185	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHF2_MOUSE
NC score	0.653246 (rank : 19)	θ value	3.63628e-17 (rank : 20)
Query Neighborhood Hits	151	Target Neighborhood Hits	77	Shared Neighborhood Hits	63
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.653078 (rank : 20)	θ value	8.10077e-17 (rank : 21)
Query Neighborhood Hits	151	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ARHG4_HUMAN
NC score	0.643692 (rank : 21)	θ value	2.7842e-17 (rank : 18)
Query Neighborhood Hits	151	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PKHF1_HUMAN
NC score	0.642134 (rank : 22)	θ value	2.60593e-15 (rank : 28)
Query Neighborhood Hits	151	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

NGEF_HUMAN
NC score	0.639230 (rank : 23)	θ value	2.60593e-15 (rank : 27)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHF1_MOUSE
NC score	0.638950 (rank : 24)	θ value	3.40345e-15 (rank : 30)
Query Neighborhood Hits	151	Target Neighborhood Hits	80	Shared Neighborhood Hits	58
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHGG_HUMAN
NC score	0.632093 (rank : 25)	θ value	5.62301e-10 (rank : 60)
Query Neighborhood Hits	151	Target Neighborhood Hits	129	Shared Neighborhood Hits	69
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_MOUSE
NC score	0.627051 (rank : 26)	θ value	1.99529e-15 (rank : 25)
Query Neighborhood Hits	151	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG9_HUMAN
NC score	0.622880 (rank : 27)	θ value	7.09661e-13 (rank : 42)
Query Neighborhood Hits	151	Target Neighborhood Hits	235	Shared Neighborhood Hits	73
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.621343 (rank : 28)	θ value	9.26847e-13 (rank : 44)
Query Neighborhood Hits	151	Target Neighborhood Hits	234	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGG_MOUSE
NC score	0.613627 (rank : 29)	θ value	8.11959e-09 (rank : 72)
Query Neighborhood Hits	151	Target Neighborhood Hits	152	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2_HUMAN
NC score	0.604956 (rank : 30)	θ value	1.58096e-12 (rank : 46)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_HUMAN
NC score	0.604044 (rank : 31)	θ value	1.33837e-11 (rank : 52)
Query Neighborhood Hits	151	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.599726 (rank : 32)	θ value	4.59992e-12 (rank : 50)
Query Neighborhood Hits	151	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGF_HUMAN
NC score	0.588295 (rank : 33)	θ value	1.74796e-11 (rank : 53)
Query Neighborhood Hits	151	Target Neighborhood Hits	214	Shared Neighborhood Hits	66
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

TIAM1_MOUSE
NC score	0.571733 (rank : 34)	θ value	2.13673e-09 (rank : 65)
Query Neighborhood Hits	151	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

MCF2L_MOUSE
NC score	0.571470 (rank : 35)	θ value	5.43371e-13 (rank : 41)
Query Neighborhood Hits	151	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

FARP2_MOUSE
NC score	0.569556 (rank : 36)	θ value	1.85889e-29 (rank : 13)
Query Neighborhood Hits	151	Target Neighborhood Hits	209	Shared Neighborhood Hits	87
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TIAM1_HUMAN
NC score	0.568587 (rank : 37)	θ value	3.64472e-09 (rank : 67)
Query Neighborhood Hits	151	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG2_MOUSE
NC score	0.567497 (rank : 38)	θ value	1.38499e-08 (rank : 76)
Query Neighborhood Hits	151	Target Neighborhood Hits	120	Shared Neighborhood Hits	63
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_MOUSE
NC score	0.563800 (rank : 39)	θ value	1.09485e-13 (rank : 33)
Query Neighborhood Hits	151	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.562312 (rank : 40)	θ value	5.43371e-13 (rank : 40)
Query Neighborhood Hits	151	Target Neighborhood Hits	82	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG1_HUMAN
NC score	0.554124 (rank : 41)	θ value	5.08577e-11 (rank : 55)
Query Neighborhood Hits	151	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

FARP2_HUMAN
NC score	0.548710 (rank : 42)	θ value	2.59989e-23 (rank : 16)
Query Neighborhood Hits	151	Target Neighborhood Hits	240	Shared Neighborhood Hits	82
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG8_HUMAN
NC score	0.546924 (rank : 43)	θ value	1.47974e-10 (rank : 59)
Query Neighborhood Hits	151	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

HAPIP_HUMAN
NC score	0.538810 (rank : 44)	θ value	3.52202e-12 (rank : 49)
Query Neighborhood Hits	151	Target Neighborhood Hits	350	Shared Neighborhood Hits	80
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

LBC_HUMAN
NC score	0.536571 (rank : 45)	θ value	7.34386e-10 (rank : 62)
Query Neighborhood Hits	151	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ZFY28_HUMAN
NC score	0.533203 (rank : 46)	θ value	2.20605e-14 (rank : 32)
Query Neighborhood Hits	151	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ARHG1_MOUSE
NC score	0.530007 (rank : 47)	θ value	2.98157e-11 (rank : 54)
Query Neighborhood Hits	151	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
NC score	0.525594 (rank : 48)	θ value	4.0297e-08 (rank : 81)
Query Neighborhood Hits	151	Target Neighborhood Hits	375	Shared Neighborhood Hits	71
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FARP1_HUMAN
NC score	0.521100 (rank : 49)	θ value	1.12775e-26 (rank : 14)
Query Neighborhood Hits	151	Target Neighborhood Hits	241	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

GNRP_MOUSE
NC score	0.518647 (rank : 50)	θ value	1.09485e-13 (rank : 35)
Query Neighborhood Hits	151	Target Neighborhood Hits	191	Shared Neighborhood Hits	72
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG2_HUMAN
NC score	0.514917 (rank : 51)	θ value	4.0297e-08 (rank : 80)
Query Neighborhood Hits	151	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

PKHG4_HUMAN
NC score	0.510695 (rank : 52)	θ value	2.61198e-07 (rank : 86)
Query Neighborhood Hits	151	Target Neighborhood Hits	200	Shared Neighborhood Hits	58
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZFY21_MOUSE
NC score	0.508722 (rank : 53)	θ value	1.80886e-08 (rank : 79)
Query Neighborhood Hits	151	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFYV9_HUMAN
NC score	0.508113 (rank : 54)	θ value	2.0648e-12 (rank : 48)
Query Neighborhood Hits	151	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY21_HUMAN
NC score	0.502744 (rank : 55)	θ value	8.11959e-09 (rank : 74)
Query Neighborhood Hits	151	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ARHGC_HUMAN
NC score	0.501134 (rank : 56)	θ value	1.06045e-08 (rank : 75)
Query Neighborhood Hits	151	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.499676 (rank : 57)	θ value	2.79066e-09 (rank : 66)
Query Neighborhood Hits	151	Target Neighborhood Hits	344	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ZFY16_MOUSE
NC score	0.492522 (rank : 58)	θ value	5.08577e-11 (rank : 57)
Query Neighborhood Hits	151	Target Neighborhood Hits	108	Shared Neighborhood Hits	50
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ARHG7_HUMAN
NC score	0.490799 (rank : 59)	θ value	2.0648e-12 (rank : 47)
Query Neighborhood Hits	151	Target Neighborhood Hits	347	Shared Neighborhood Hits	76
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GNRP_HUMAN
NC score	0.489449 (rank : 60)	θ value	1.86753e-13 (rank : 36)
Query Neighborhood Hits	151	Target Neighborhood Hits	239	Shared Neighborhood Hits	70
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ZFY16_HUMAN
NC score	0.483962 (rank : 61)	θ value	5.08577e-11 (rank : 56)
Query Neighborhood Hits	151	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ARHG8_MOUSE
NC score	0.477544 (rank : 62)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	151	Target Neighborhood Hits	79	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG7_MOUSE
NC score	0.471850 (rank : 63)	θ value	8.67504e-11 (rank : 58)
Query Neighborhood Hits	151	Target Neighborhood Hits	396	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV_MOUSE
NC score	0.448922 (rank : 64)	θ value	4.16044e-13 (rank : 39)
Query Neighborhood Hits	151	Target Neighborhood Hits	430	Shared Neighborhood Hits	71
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.441729 (rank : 65)	θ value	4.16044e-13 (rank : 38)
Query Neighborhood Hits	151	Target Neighborhood Hits	452	Shared Neighborhood Hits	71
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DNMBP_MOUSE
NC score	0.438714 (rank : 66)	θ value	1.43324e-05 (rank : 99)
Query Neighborhood Hits	151	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_MOUSE
NC score	0.435757 (rank : 67)	θ value	1.09739e-05 (rank : 97)
Query Neighborhood Hits	151	Target Neighborhood Hits	456	Shared Neighborhood Hits	75
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.431069 (rank : 68)	θ value	8.40245e-06 (rank : 96)
Query Neighborhood Hits	151	Target Neighborhood Hits	453	Shared Neighborhood Hits	76
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN2_HUMAN
NC score	0.429530 (rank : 69)	θ value	2.60593e-15 (rank : 26)
Query Neighborhood Hits	151	Target Neighborhood Hits	1173	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

BCR_HUMAN
NC score	0.428753 (rank : 70)	θ value	9.26847e-13 (rank : 45)
Query Neighborhood Hits	151	Target Neighborhood Hits	204	Shared Neighborhood Hits	63
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

VAV3_MOUSE
NC score	0.427410 (rank : 71)	θ value	3.77169e-06 (rank : 92)
Query Neighborhood Hits	151	Target Neighborhood Hits	404	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ABR_HUMAN
NC score	0.425838 (rank : 72)	θ value	3.18553e-13 (rank : 37)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	64
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

VAV3_HUMAN
NC score	0.425019 (rank : 73)	θ value	1.29631e-06 (rank : 88)
Query Neighborhood Hits	151	Target Neighborhood Hits	398	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

DNMBP_HUMAN
NC score	0.421868 (rank : 74)	θ value	2.88788e-06 (rank : 91)
Query Neighborhood Hits	151	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RGNEF_MOUSE
NC score	0.418295 (rank : 75)	θ value	3.41135e-07 (rank : 87)
Query Neighborhood Hits	151	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG6_HUMAN
NC score	0.414543 (rank : 76)	θ value	1.38499e-08 (rank : 77)
Query Neighborhood Hits	151	Target Neighborhood Hits	376	Shared Neighborhood Hits	64
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ITSN2_MOUSE
NC score	0.407133 (rank : 77)	θ value	7.09661e-13 (rank : 43)
Query Neighborhood Hits	151	Target Neighborhood Hits	1371	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.399869 (rank : 78)	θ value	3.63628e-17 (rank : 19)
Query Neighborhood Hits	151	Target Neighborhood Hits	1757	Shared Neighborhood Hits	87
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.398691 (rank : 79)	θ value	1.80466e-16 (rank : 22)
Query Neighborhood Hits	151	Target Neighborhood Hits	1669	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

HGS_HUMAN
NC score	0.387440 (rank : 80)	θ value	1.53129e-07 (rank : 83)
Query Neighborhood Hits	151	Target Neighborhood Hits	517	Shared Neighborhood Hits	56
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.386764 (rank : 81)	θ value	1.99992e-07 (rank : 85)
Query Neighborhood Hits	151	Target Neighborhood Hits	589	Shared Neighborhood Hits	55
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ARHG6_MOUSE
NC score	0.384627 (rank : 82)	θ value	1.99992e-07 (rank : 84)
Query Neighborhood Hits	151	Target Neighborhood Hits	394	Shared Neighborhood Hits	65
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ZFYV1_HUMAN
NC score	0.378255 (rank : 83)	θ value	1.09739e-05 (rank : 98)
Query Neighborhood Hits	151	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.374588 (rank : 84)	θ value	1.43324e-05 (rank : 101)
Query Neighborhood Hits	151	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

RBNS5_HUMAN
NC score	0.371517 (rank : 85)	θ value	0.00020696 (rank : 105)
Query Neighborhood Hits	151	Target Neighborhood Hits	242	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.364088 (rank : 86)	θ value	0.00020696 (rank : 106)
Query Neighborhood Hits	151	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

FYV1_HUMAN
NC score	0.332409 (rank : 87)	θ value	4.92598e-06 (rank : 93)
Query Neighborhood Hits	151	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.329832 (rank : 88)	θ value	4.92598e-06 (rank : 94)
Query Neighborhood Hits	151	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY19_HUMAN
NC score	0.326543 (rank : 89)	θ value	0.0330416 (rank : 112)
Query Neighborhood Hits	151	Target Neighborhood Hits	206	Shared Neighborhood Hits	49
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
NC score	0.319771 (rank : 90)	θ value	0.0330416 (rank : 113)
Query Neighborhood Hits	151	Target Neighborhood Hits	143	Shared Neighborhood Hits	50
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

SOS2_HUMAN
NC score	0.307398 (rank : 91)	θ value	8.97725e-08 (rank : 82)
Query Neighborhood Hits	151	Target Neighborhood Hits	193	Shared Neighborhood Hits	41
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.302293 (rank : 92)	θ value	1.43324e-05 (rank : 100)
Query Neighborhood Hits	151	Target Neighborhood Hits	274	Shared Neighborhood Hits	39
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

WDFY1_HUMAN
NC score	0.291535 (rank : 93)	θ value	3.19293e-05 (rank : 102)
Query Neighborhood Hits	151	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY3_MOUSE
NC score	0.288165 (rank : 94)	θ value	6.21693e-09 (rank : 71)
Query Neighborhood Hits	151	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.287898 (rank : 95)	θ value	6.21693e-09 (rank : 70)
Query Neighborhood Hits	151	Target Neighborhood Hits	348	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

RUFY2_MOUSE
NC score	0.286872 (rank : 96)	θ value	7.34386e-10 (rank : 63)
Query Neighborhood Hits	151	Target Neighborhood Hits	820	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.284840 (rank : 97)	θ value	1.38499e-08 (rank : 78)
Query Neighborhood Hits	151	Target Neighborhood Hits	765	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

SOS1_MOUSE
NC score	0.283721 (rank : 98)	θ value	7.1131e-05 (rank : 103)
Query Neighborhood Hits	151	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

RUFY1_HUMAN
NC score	0.279933 (rank : 99)	θ value	4.76016e-09 (rank : 69)
Query Neighborhood Hits	151	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY2_MOUSE
NC score	0.269514 (rank : 100)	θ value	0.000602161 (rank : 108)
Query Neighborhood Hits	151	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

MTMR3_HUMAN
NC score	0.269065 (rank : 101)	θ value	4.92598e-06 (rank : 95)
Query Neighborhood Hits	151	Target Neighborhood Hits	163	Shared Neighborhood Hits	52
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

WDFY2_HUMAN
NC score	0.267691 (rank : 102)	θ value	0.000602161 (rank : 107)
Query Neighborhood Hits	151	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_HUMAN
NC score	0.236368 (rank : 103)	θ value	5.62301e-10 (rank : 61)
Query Neighborhood Hits	151	Target Neighborhood Hits	1208	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

DUET_HUMAN
NC score	0.223049 (rank : 104)	θ value	3.07829e-16 (rank : 23)
Query Neighborhood Hits	151	Target Neighborhood Hits	1220	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.215053 (rank : 105)	θ value	2.60593e-15 (rank : 29)
Query Neighborhood Hits	151	Target Neighborhood Hits	1580	Shared Neighborhood Hits	83
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZFY27_MOUSE
NC score	0.197358 (rank : 106)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	151	Target Neighborhood Hits	53	Shared Neighborhood Hits	42
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.191635 (rank : 107)	θ value	6.88961 (rank : 147)
Query Neighborhood Hits	151	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FYCO1_HUMAN
NC score	0.188778 (rank : 108)	θ value	0.00020696 (rank : 104)
Query Neighborhood Hits	151	Target Neighborhood Hits	1149	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

EEA1_MOUSE
NC score	0.188565 (rank : 109)	θ value	4.76016e-09 (rank : 68)
Query Neighborhood Hits	151	Target Neighborhood Hits	1637	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

ANFY1_MOUSE
NC score	0.186005 (rank : 110)	θ value	2.21117e-06 (rank : 89)
Query Neighborhood Hits	151	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.185829 (rank : 111)	θ value	2.88788e-06 (rank : 90)
Query Neighborhood Hits	151	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

EEA1_HUMAN
NC score	0.173832 (rank : 112)	θ value	1.63604e-09 (rank : 64)
Query Neighborhood Hits	151	Target Neighborhood Hits	1796	Shared Neighborhood Hits	70
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FYCO1_MOUSE
NC score	0.173536 (rank : 113)	θ value	0.00665767 (rank : 109)
Query Neighborhood Hits	151	Target Neighborhood Hits	1059	Shared Neighborhood Hits	66
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

PKHA6_HUMAN
NC score	0.150855 (rank : 114)	θ value	1.38821 (rank : 125)
Query Neighborhood Hits	151	Target Neighborhood Hits	556	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.147923 (rank : 115)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	151	Target Neighborhood Hits	591	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ALS2_MOUSE
NC score	0.140296 (rank : 116)	θ value	0.0113563 (rank : 110)
Query Neighborhood Hits	151	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

NCF1_HUMAN
NC score	0.121101 (rank : 117)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	151	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ALS2_HUMAN
NC score	0.120354 (rank : 118)	θ value	0.279714 (rank : 116)
Query Neighborhood Hits	151	Target Neighborhood Hits	121	Shared Neighborhood Hits	24
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

SH3K1_HUMAN
NC score	0.118877 (rank : 119)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	151	Target Neighborhood Hits	341	Shared Neighborhood Hits	27
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_MOUSE
NC score	0.113102 (rank : 120)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	151	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_HUMAN
NC score	0.110566 (rank : 121)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	151	Target Neighborhood Hits	315	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.110256 (rank : 122)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	151	Target Neighborhood Hits	332	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.109684 (rank : 123)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	151	Target Neighborhood Hits	336	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

OBSCN_HUMAN
NC score	0.104199 (rank : 124)	θ value	8.11959e-09 (rank : 73)
Query Neighborhood Hits	151	Target Neighborhood Hits	1931	Shared Neighborhood Hits	60
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SRBS1_MOUSE
NC score	0.100271 (rank : 125)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	151	Target Neighborhood Hits	409	Shared Neighborhood Hits	24
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.099693 (rank : 126)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	151	Target Neighborhood Hits	229	Shared Neighborhood Hits	26
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SRBS1_HUMAN
NC score	0.099238 (rank : 127)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	151	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PKHA5_HUMAN
NC score	0.096752 (rank : 128)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	151	Target Neighborhood Hits	455	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

MELPH_MOUSE
NC score	0.096262 (rank : 129)	θ value	0.0431538 (rank : 114)
Query Neighborhood Hits	151	Target Neighborhood Hits	112	Shared Neighborhood Hits	17
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

VINEX_HUMAN
NC score	0.095877 (rank : 130)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	151	Target Neighborhood Hits	270	Shared Neighborhood Hits	25
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.095326 (rank : 131)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	151	Target Neighborhood Hits	286	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCK1_HUMAN
NC score	0.094129 (rank : 132)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	151	Target Neighborhood Hits	312	Shared Neighborhood Hits	26
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

MYRIP_MOUSE
NC score	0.092710 (rank : 133)	θ value	0.0330416 (rank : 111)
Query Neighborhood Hits	151	Target Neighborhood Hits	207	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

PKHA4_MOUSE
NC score	0.092106 (rank : 134)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	151	Target Neighborhood Hits	202	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

NCK2_HUMAN
NC score	0.090858 (rank : 135)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	151	Target Neighborhood Hits	310	Shared Neighborhood Hits	26
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PKHA4_HUMAN
NC score	0.090702 (rank : 136)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	151	Target Neighborhood Hits	283	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

STAM1_HUMAN
NC score	0.089628 (rank : 137)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	151	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_HUMAN
NC score	0.089154 (rank : 138)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	151	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.088996 (rank : 139)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	151	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_MOUSE
NC score	0.088716 (rank : 140)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	151	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP_HUMAN
NC score	0.087101 (rank : 141)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

STAM2_MOUSE
NC score	0.086863 (rank : 142)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	151	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.086107 (rank : 143)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	151	Target Neighborhood Hits	288	Shared Neighborhood Hits	24
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

GRAP_MOUSE
NC score	0.085792 (rank : 144)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	151	Target Neighborhood Hits	309	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAC_HUMAN
NC score	0.084946 (rank : 145)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	151	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SWP70_HUMAN
NC score	0.083900 (rank : 146)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	151	Target Neighborhood Hits	973	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MELPH_HUMAN
NC score	0.083144 (rank : 147)	θ value	0.62314 (rank : 123)
Query Neighborhood Hits	151	Target Neighborhood Hits	145	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

STAC_MOUSE
NC score	0.082153 (rank : 148)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	151	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SWP70_MOUSE
NC score	0.080123 (rank : 149)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	151	Target Neighborhood Hits	1097	Shared Neighborhood Hits	51
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GRB2_HUMAN
NC score	0.078248 (rank : 150)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	151	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.078227 (rank : 151)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	151	Target Neighborhood Hits	312	Shared Neighborhood Hits	21
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

RUFY3_MOUSE
NC score	0.078206 (rank : 152)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	151	Target Neighborhood Hits	579	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

ABI2_HUMAN
NC score	0.077831 (rank : 153)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	151	Target Neighborhood Hits	350	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.077661 (rank : 154)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	151	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STAC3_MOUSE
NC score	0.077609 (rank : 155)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	151	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

RUFY3_HUMAN
NC score	0.077511 (rank : 156)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	151	Target Neighborhood Hits	594	Shared Neighborhood Hits	14
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

STAC3_HUMAN
NC score	0.076854 (rank : 157)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	151	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

MYRIP_HUMAN
NC score	0.076851 (rank : 158)	θ value	0.125558 (rank : 115)
Query Neighborhood Hits	151	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

ABI1_MOUSE
NC score	0.075393 (rank : 159)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	151	Target Neighborhood Hits	246	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SRC8_HUMAN
NC score	0.074929 (rank : 160)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	151	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

BI2L1_HUMAN
NC score	0.074765 (rank : 161)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	151	Target Neighborhood Hits	156	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CYH3_MOUSE
NC score	0.074461 (rank : 162)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	151	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

HCLS1_MOUSE
NC score	0.074179 (rank : 163)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	151	Target Neighborhood Hits	329	Shared Neighborhood Hits	23
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PPIP1_HUMAN
NC score	0.073907 (rank : 164)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	151	Target Neighborhood Hits	389	Shared Neighborhood Hits	26
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

HCLS1_HUMAN
NC score	0.073633 (rank : 165)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	151	Target Neighborhood Hits	358	Shared Neighborhood Hits	22
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SRC8_MOUSE
NC score	0.073353 (rank : 166)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	151	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SH3G3_MOUSE
NC score	0.073007 (rank : 167)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	151	Target Neighborhood Hits	236	Shared Neighborhood Hits	21
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

GRAP2_HUMAN
NC score	0.072130 (rank : 168)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	151	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PPIP1_MOUSE
NC score	0.072093 (rank : 169)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	151	Target Neighborhood Hits	377	Shared Neighborhood Hits	29
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

GRAP2_MOUSE
NC score	0.071938 (rank : 170)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	151	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3G1_HUMAN
NC score	0.071392 (rank : 171)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	24
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
NC score	0.071334 (rank : 172)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	151	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
NC score	0.070911 (rank : 173)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	151	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CNKR1_HUMAN
NC score	0.070601 (rank : 174)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	151	Target Neighborhood Hits	154	Shared Neighborhood Hits	24
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

ABI1_HUMAN
NC score	0.070130 (rank : 175)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	151	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G2_MOUSE
NC score	0.069347 (rank : 176)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	151	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

AHI1_HUMAN
NC score	0.069173 (rank : 177)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	151	Target Neighborhood Hits	537	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CRKL_HUMAN
NC score	0.068183 (rank : 178)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	151	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

PLCG1_MOUSE
NC score	0.068086 (rank : 179)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	151	Target Neighborhood Hits	314	Shared Neighborhood Hits	20
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G1_MOUSE
NC score	0.067691 (rank : 180)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	151	Target Neighborhood Hits	291	Shared Neighborhood Hits	22
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ABI3_HUMAN
NC score	0.067597 (rank : 181)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	151	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DGKH_HUMAN
NC score	0.066861 (rank : 182)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	151	Target Neighborhood Hits	255	Shared Neighborhood Hits	33
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

PLCG1_HUMAN
NC score	0.066683 (rank : 183)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	151	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRK_MOUSE
NC score	0.066624 (rank : 184)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	151	Target Neighborhood Hits	314	Shared Neighborhood Hits	22
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_MOUSE
NC score	0.066508 (rank : 185)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	20
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ABI3_MOUSE
NC score	0.066416 (rank : 186)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	151	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CYH4_MOUSE
NC score	0.065606 (rank : 187)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	151	Target Neighborhood Hits	134	Shared Neighborhood Hits	26
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

OSTF1_HUMAN
NC score	0.065479 (rank : 188)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	151	Target Neighborhood Hits	466	Shared Neighborhood Hits	25
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

TCGAP_MOUSE
NC score	0.065053 (rank : 189)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	151	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

OSTF1_MOUSE
NC score	0.064781 (rank : 190)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	151	Target Neighborhood Hits	467	Shared Neighborhood Hits	25
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

GRP3_HUMAN
NC score	0.063936 (rank : 191)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	151	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

SHAN2_MOUSE
NC score	0.063568 (rank : 192)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	151	Target Neighborhood Hits	446	Shared Neighborhood Hits	27
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TCGAP_HUMAN
NC score	0.063553 (rank : 193)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	151	Target Neighborhood Hits	872	Shared Neighborhood Hits	31
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CRK_HUMAN
NC score	0.063471 (rank : 194)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	151	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NEBL_HUMAN
NC score	0.063411 (rank : 195)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	151	Target Neighborhood Hits	457	Shared Neighborhood Hits	26
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

AHI1_MOUSE
NC score	0.062284 (rank : 196)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	151	Target Neighborhood Hits	496	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SPTA2_HUMAN
NC score	0.062239 (rank : 197)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	151	Target Neighborhood Hits	888	Shared Neighborhood Hits	36
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DBNL_HUMAN
NC score	0.061971 (rank : 198)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	151	Target Neighborhood Hits	244	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

NOXO1_MOUSE
NC score	0.061192 (rank : 199)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	151	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

RFFL_MOUSE
NC score	0.060995 (rank : 200)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	151	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

CYH4_HUMAN
NC score	0.060532 (rank : 201)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	151	Target Neighborhood Hits	135	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

BI2L1_MOUSE
NC score	0.060485 (rank : 202)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	151	Target Neighborhood Hits	197	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PKHA2_MOUSE
NC score	0.060226 (rank : 203)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	151	Target Neighborhood Hits	116	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

RNF34_MOUSE
NC score	0.060190 (rank : 204)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	151	Target Neighborhood Hits	160	Shared Neighborhood Hits	32
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

DBNL_MOUSE
NC score	0.059253 (rank : 205)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	151	Target Neighborhood Hits	306	Shared Neighborhood Hits	20
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CYH1_HUMAN
NC score	0.059197 (rank : 206)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	151	Target Neighborhood Hits	184	Shared Neighborhood Hits	29
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

OSBL9_HUMAN
NC score	0.059186 (rank : 207)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	151	Target Neighborhood Hits	138	Shared Neighborhood Hits	24
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

RHG04_HUMAN
NC score	0.058764 (rank : 208)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	151	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NPHP1_MOUSE
NC score	0.058541 (rank : 209)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	151	Target Neighborhood Hits	267	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

EFS_MOUSE
NC score	0.058355 (rank : 210)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	151	Target Neighborhood Hits	389	Shared Neighborhood Hits	21
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

LASP1_HUMAN
NC score	0.057486 (rank : 211)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	151	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PEX13_MOUSE
NC score	0.057368 (rank : 212)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	151	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SPTA1_MOUSE
NC score	0.056833 (rank : 213)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	151	Target Neighborhood Hits	675	Shared Neighborhood Hits	34
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

3BP2_HUMAN
NC score	0.056541 (rank : 214)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	151	Target Neighborhood Hits	296	Shared Neighborhood Hits	23
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CYH1_MOUSE
NC score	0.056518 (rank : 215)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	151	Target Neighborhood Hits	176	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

RPGF1_HUMAN
NC score	0.056492 (rank : 216)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	151	Target Neighborhood Hits	262	Shared Neighborhood Hits	7
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

ANM2_HUMAN
NC score	0.056033 (rank : 217)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

LASP1_MOUSE
NC score	0.055857 (rank : 218)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	151	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

RNF34_HUMAN
NC score	0.055810 (rank : 219)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	151	Target Neighborhood Hits	153	Shared Neighborhood Hits	29
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

PEX13_HUMAN
NC score	0.055807 (rank : 220)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	151	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

BCAR1_MOUSE
NC score	0.055688 (rank : 221)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	151	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SPTA1_HUMAN
NC score	0.055559 (rank : 222)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	151	Target Neighborhood Hits	748	Shared Neighborhood Hits	37
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CYH2_HUMAN
NC score	0.055542 (rank : 223)	θ value	0.47712 (rank : 119)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	26
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.055476 (rank : 224)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	151	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_HUMAN
NC score	0.055420 (rank : 225)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	151	Target Neighborhood Hits	137	Shared Neighborhood Hits	22
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

BCAR1_HUMAN
NC score	0.055148 (rank : 226)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	151	Target Neighborhood Hits	554	Shared Neighborhood Hits	25
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PLCG2_HUMAN
NC score	0.055001 (rank : 227)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	151	Target Neighborhood Hits	280	Shared Neighborhood Hits	16
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

CNKR2_MOUSE
NC score	0.054900 (rank : 228)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	151	Target Neighborhood Hits	197	Shared Neighborhood Hits	21
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.054673 (rank : 229)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	151	Target Neighborhood Hits	197	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

NOXO1_HUMAN
NC score	0.054082 (rank : 230)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	151	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SHAN1_HUMAN
NC score	0.054044 (rank : 231)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	151	Target Neighborhood Hits	1041	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PACN2_MOUSE
NC score	0.053657 (rank : 232)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	151	Target Neighborhood Hits	382	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PKHA2_HUMAN
NC score	0.053140 (rank : 233)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	151	Target Neighborhood Hits	119	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

ASPP1_MOUSE
NC score	0.053097 (rank : 234)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	151	Target Neighborhood Hits	1244	Shared Neighborhood Hits	43
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CT032_HUMAN
NC score	0.053095 (rank : 235)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	151	Target Neighborhood Hits	235	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PACN2_HUMAN
NC score	0.053014 (rank : 236)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	151	Target Neighborhood Hits	339	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CJ064_HUMAN
NC score	0.052960 (rank : 237)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	151	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

DGKD_HUMAN
NC score	0.052913 (rank : 238)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	151	Target Neighborhood Hits	231	Shared Neighborhood Hits	19
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

FNBP2_HUMAN
NC score	0.052515 (rank : 239)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	151	Target Neighborhood Hits	432	Shared Neighborhood Hits	27
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

3BP2_MOUSE
NC score	0.052511 (rank : 240)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	151	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANM2_MOUSE
NC score	0.052272 (rank : 241)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RFFL_HUMAN
NC score	0.052085 (rank : 242)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	151	Target Neighborhood Hits	175	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

NPHP1_HUMAN
NC score	0.051992 (rank : 243)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	151	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

E41LB_HUMAN
NC score	0.051900 (rank : 244)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	151	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

SRGP1_HUMAN
NC score	0.051368 (rank : 245)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	151	Target Neighborhood Hits	390	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

E41L3_HUMAN
NC score	0.050977 (rank : 246)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	151	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L5_HUMAN
NC score	0.050658 (rank : 247)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	151	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.050622 (rank : 248)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	151	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

DDEF2_HUMAN
NC score	0.050570 (rank : 249)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	151	Target Neighborhood Hits	599	Shared Neighborhood Hits	34
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.050567 (rank : 250)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	151	Target Neighborhood Hits	625	Shared Neighborhood Hits	33
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RHG26_HUMAN
NC score	0.050502 (rank : 251)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	151	Target Neighborhood Hits	281	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

REPS1_MOUSE
NC score	0.050414 (rank : 252)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	151	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

41_HUMAN
NC score	0.050013 (rank : 253)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	151	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

SYTL4_HUMAN
NC score	0.048621 (rank : 254)	θ value	0.279714 (rank : 117)
Query Neighborhood Hits	151	Target Neighborhood Hits	138	Shared Neighborhood Hits	21
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

NHLC1_MOUSE
NC score	0.047964 (rank : 255)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	151	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

DGKK_HUMAN
NC score	0.044347 (rank : 256)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	151	Target Neighborhood Hits	378	Shared Neighborhood Hits	17
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

CENB5_HUMAN
NC score	0.039875 (rank : 257)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	151	Target Neighborhood Hits	395	Shared Neighborhood Hits	26
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CP250_HUMAN
NC score	0.036875 (rank : 258)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	151	Target Neighborhood Hits	1805	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

SYTL4_MOUSE
NC score	0.035541 (rank : 259)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	151	Target Neighborhood Hits	137	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYNE1_HUMAN
NC score	0.034928 (rank : 260)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	151	Target Neighborhood Hits	1484	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SYTL3_MOUSE
NC score	0.032102 (rank : 261)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	151	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

PKHA1_HUMAN
NC score	0.031425 (rank : 262)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	151	Target Neighborhood Hits	127	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

GCH1_MOUSE
NC score	0.018114 (rank : 263)	θ value	1.38821 (rank : 124)
Query Neighborhood Hits	151	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q05915	Gene names	Gch1, Gch
Domain Architecture
Description	GTP cyclohydrolase I precursor (EC 3.5.4.16) (GTP-CH-I).

STOX1_HUMAN
NC score	0.014670 (rank : 264)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	151	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZVD7, Q4F8Q6, Q5I946, Q5I947, Q5I948, Q5VX38, Q5VX39, Q6ZRY3, Q96LR3, Q96LS0	Gene names	STOX1, C10orf24
Domain Architecture	No domain graphic available
Description	Storkhead-box protein 1 (Winged helix domain-containing protein).

TIM_HUMAN
NC score	0.014039 (rank : 265)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	151	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNS1, O94802, Q86VM1, Q8IWH3	Gene names	TIMELESS, TIM, TIM1, TIMELESS1
Domain Architecture	No domain graphic available
Description	Timeless homolog (hTIM).

TIM_MOUSE
NC score	0.011995 (rank : 266)	θ value	6.88961 (rank : 146)
Query Neighborhood Hits	151	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R1X4, Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7	Gene names	Timeless, Tim1, Timeless1
Domain Architecture	No domain graphic available
Description	Timeless homolog (mTim).

DDFL1_MOUSE
NC score	0.011639 (rank : 267)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	151	Target Neighborhood Hits	324	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CHM4A_HUMAN
NC score	0.011188 (rank : 268)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	151	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BY43, Q32Q79, Q86SZ8, Q96QJ9, Q9P026	Gene names	CHMP4A, C14orf123, SHAX2
Domain Architecture
Description	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (Vacuolar protein sorting 7-1) (SNF7-1) (hSnf-1) (SNF7 homolog associated with Alix-2).

CUTL2_MOUSE
NC score	0.010245 (rank : 269)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	151	Target Neighborhood Hits	771	Shared Neighborhood Hits	17
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

ARMX1_HUMAN
NC score	0.005975 (rank : 270)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	151	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P291, Q53HK2, Q9H2Q0	Gene names	ARMCX1, ALEX1
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 1 (Protein ALEX1) (ARM protein lost in epithelial cancers on chromosome X 1).

CLD23_HUMAN
NC score	0.004072 (rank : 271)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	151	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B33	Gene names	CLDN23
Domain Architecture
Description	Claudin-23.

TBX6_MOUSE
NC score	0.001333 (rank : 272)	θ value	6.88961 (rank : 145)
Query Neighborhood Hits	151	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	P70327	Gene names	Tbx6
Domain Architecture
Description	T-box transcription factor TBX6 (T-box protein 6).

T2R49_HUMAN
NC score	0.000945 (rank : 273)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	151	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	P59543, P59549, Q645X9	Gene names	TAS2R49
Domain Architecture
Description	Taste receptor type 2 member 49 (T2R49) (T2R56).

BARH2_HUMAN
NC score	0.000183 (rank : 274)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	151	Target Neighborhood Hits	419	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NY43, Q7Z4N7	Gene names	BARHL2
Domain Architecture
Description	BarH-like 2 homeobox protein.

PGCB_MOUSE
NC score	-0.001510 (rank : 275)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	151	Target Neighborhood Hits	459	Shared Neighborhood Hits	3
SwissProt Accessions	Q61361	Gene names	Bcan
Domain Architecture
Description	Brevican core protein precursor.