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Network neighborhood for query Sequence : FGD4_HUMAN

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FGD4_HUMAN
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	219	Target Neighborhood Hits	219	Shared Neighborhood Hits	219
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	0 (rank : 2)	NC score	0.993086 (rank : 2)
Query Neighborhood Hits	219	Target Neighborhood Hits	227	Shared Neighborhood Hits	174
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
θ value	1.0077e-184 (rank : 3)	NC score	0.954965 (rank : 6)
Query Neighborhood Hits	219	Target Neighborhood Hits	367	Shared Neighborhood Hits	137
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	5.00115e-184 (rank : 4)	NC score	0.952679 (rank : 7)
Query Neighborhood Hits	219	Target Neighborhood Hits	387	Shared Neighborhood Hits	134
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	5.36813e-170 (rank : 5)	NC score	0.975492 (rank : 3)
Query Neighborhood Hits	219	Target Neighborhood Hits	151	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	3.25673e-167 (rank : 6)	NC score	0.971939 (rank : 4)
Query Neighborhood Hits	219	Target Neighborhood Hits	163	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	2.511e-143 (rank : 7)	NC score	0.957184 (rank : 5)
Query Neighborhood Hits	219	Target Neighborhood Hits	249	Shared Neighborhood Hits	117
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	1.02182e-136 (rank : 8)	NC score	0.952578 (rank : 8)
Query Neighborhood Hits	219	Target Neighborhood Hits	257	Shared Neighborhood Hits	126
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD6_MOUSE
θ value	3.81361e-83 (rank : 9)	NC score	0.900326 (rank : 9)
Query Neighborhood Hits	219	Target Neighborhood Hits	282	Shared Neighborhood Hits	128
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
θ value	2.73302e-81 (rank : 10)	NC score	0.899175 (rank : 10)
Query Neighborhood Hits	219	Target Neighborhood Hits	237	Shared Neighborhood Hits	129
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
θ value	4.84666e-62 (rank : 11)	NC score	0.830400 (rank : 11)
Query Neighborhood Hits	219	Target Neighborhood Hits	235	Shared Neighborhood Hits	106
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	1.97229e-55 (rank : 12)	NC score	0.818578 (rank : 12)
Query Neighborhood Hits	219	Target Neighborhood Hits	170	Shared Neighborhood Hits	104
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_HUMAN
θ value	1.08474e-45 (rank : 13)	NC score	0.565967 (rank : 39)
Query Neighborhood Hits	219	Target Neighborhood Hits	240	Shared Neighborhood Hits	96
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	2.41655e-45 (rank : 14)	NC score	0.586028 (rank : 34)
Query Neighborhood Hits	219	Target Neighborhood Hits	209	Shared Neighborhood Hits	98
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	8.89434e-40 (rank : 15)	NC score	0.538661 (rank : 46)
Query Neighborhood Hits	219	Target Neighborhood Hits	241	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PREX1_HUMAN
θ value	2.35151e-24 (rank : 16)	NC score	0.737396 (rank : 13)
Query Neighborhood Hits	219	Target Neighborhood Hits	177	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_MOUSE
θ value	4.9032e-22 (rank : 17)	NC score	0.730698 (rank : 14)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
θ value	1.42661e-21 (rank : 18)	NC score	0.717751 (rank : 15)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG4_HUMAN
θ value	7.0802e-21 (rank : 19)	NC score	0.655094 (rank : 21)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NGEF_HUMAN
θ value	4.58923e-20 (rank : 20)	NC score	0.656668 (rank : 20)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_MOUSE
θ value	7.82807e-20 (rank : 21)	NC score	0.669009 (rank : 18)
Query Neighborhood Hits	219	Target Neighborhood Hits	185	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN1_HUMAN
θ value	1.33526e-19 (rank : 22)	NC score	0.411135 (rank : 78)
Query Neighborhood Hits	219	Target Neighborhood Hits	1757	Shared Neighborhood Hits	117
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NGEF_MOUSE
θ value	2.27762e-19 (rank : 23)	NC score	0.644496 (rank : 22)
Query Neighborhood Hits	219	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ITSN1_MOUSE
θ value	3.88503e-19 (rank : 24)	NC score	0.409858 (rank : 79)
Query Neighborhood Hits	219	Target Neighborhood Hits	1669	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHGG_HUMAN
θ value	1.92812e-18 (rank : 25)	NC score	0.656941 (rank : 19)
Query Neighborhood Hits	219	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PKHF2_MOUSE
θ value	5.60996e-18 (rank : 26)	NC score	0.634891 (rank : 24)
Query Neighborhood Hits	219	Target Neighborhood Hits	77	Shared Neighborhood Hits	65
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

TRIO_HUMAN
θ value	5.60996e-18 (rank : 27)	NC score	0.218559 (rank : 105)
Query Neighborhood Hits	219	Target Neighborhood Hits	1580	Shared Neighborhood Hits	108
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
θ value	1.24977e-17 (rank : 28)	NC score	0.224385 (rank : 104)
Query Neighborhood Hits	219	Target Neighborhood Hits	1220	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

PKHF2_HUMAN
θ value	1.24977e-17 (rank : 29)	NC score	0.634333 (rank : 26)
Query Neighborhood Hits	219	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ARHG9_HUMAN
θ value	8.10077e-17 (rank : 30)	NC score	0.634380 (rank : 25)
Query Neighborhood Hits	219	Target Neighborhood Hits	235	Shared Neighborhood Hits	73
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHGG_MOUSE
θ value	1.80466e-16 (rank : 31)	NC score	0.638342 (rank : 23)
Query Neighborhood Hits	219	Target Neighborhood Hits	152	Shared Neighborhood Hits	70
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

HAPIP_HUMAN
θ value	1.80466e-16 (rank : 32)	NC score	0.542060 (rank : 43)
Query Neighborhood Hits	219	Target Neighborhood Hits	350	Shared Neighborhood Hits	98
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG9_MOUSE
θ value	2.35696e-16 (rank : 33)	NC score	0.633053 (rank : 27)
Query Neighborhood Hits	219	Target Neighborhood Hits	234	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG5_HUMAN
θ value	4.02038e-16 (rank : 34)	NC score	0.670625 (rank : 17)
Query Neighborhood Hits	219	Target Neighborhood Hits	172	Shared Neighborhood Hits	74
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGF_HUMAN
θ value	5.25075e-16 (rank : 35)	NC score	0.602395 (rank : 30)
Query Neighborhood Hits	219	Target Neighborhood Hits	214	Shared Neighborhood Hits	68
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PKHF1_HUMAN
θ value	8.95645e-16 (rank : 36)	NC score	0.622515 (rank : 28)
Query Neighborhood Hits	219	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	1.52774e-15 (rank : 37)	NC score	0.619085 (rank : 29)
Query Neighborhood Hits	219	Target Neighborhood Hits	80	Shared Neighborhood Hits	63
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHG1_MOUSE
θ value	1.99529e-15 (rank : 38)	NC score	0.541446 (rank : 44)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ITSN2_HUMAN
θ value	1.99529e-15 (rank : 39)	NC score	0.438086 (rank : 70)
Query Neighborhood Hits	219	Target Neighborhood Hits	1173	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	1.99529e-15 (rank : 40)	NC score	0.417585 (rank : 75)
Query Neighborhood Hits	219	Target Neighborhood Hits	1371	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG1_HUMAN
θ value	3.40345e-15 (rank : 41)	NC score	0.566971 (rank : 37)
Query Neighborhood Hits	219	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ABR_HUMAN
θ value	9.90251e-15 (rank : 42)	NC score	0.422194 (rank : 74)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG7_HUMAN
θ value	9.90251e-15 (rank : 43)	NC score	0.496080 (rank : 55)
Query Neighborhood Hits	219	Target Neighborhood Hits	347	Shared Neighborhood Hits	79
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG2_MOUSE
θ value	2.20605e-14 (rank : 44)	NC score	0.577032 (rank : 35)
Query Neighborhood Hits	219	Target Neighborhood Hits	120	Shared Neighborhood Hits	65
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

PKHG1_HUMAN
θ value	2.88119e-14 (rank : 45)	NC score	0.692430 (rank : 16)
Query Neighborhood Hits	219	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

GNRP_HUMAN
θ value	3.76295e-14 (rank : 46)	NC score	0.489140 (rank : 56)
Query Neighborhood Hits	219	Target Neighborhood Hits	239	Shared Neighborhood Hits	83
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	8.38298e-14 (rank : 47)	NC score	0.522744 (rank : 49)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	80
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGC_HUMAN
θ value	1.09485e-13 (rank : 48)	NC score	0.519705 (rank : 51)
Query Neighborhood Hits	219	Target Neighborhood Hits	351	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	1.42992e-13 (rank : 49)	NC score	0.518857 (rank : 52)
Query Neighborhood Hits	219	Target Neighborhood Hits	344	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

VAV3_HUMAN
θ value	4.16044e-13 (rank : 50)	NC score	0.443832 (rank : 69)
Query Neighborhood Hits	219	Target Neighborhood Hits	398	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

LBC_HUMAN
θ value	7.09661e-13 (rank : 51)	NC score	0.538370 (rank : 47)
Query Neighborhood Hits	219	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

VAV2_MOUSE
θ value	7.09661e-13 (rank : 52)	NC score	0.455829 (rank : 65)
Query Neighborhood Hits	219	Target Neighborhood Hits	456	Shared Neighborhood Hits	82
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
θ value	1.2105e-12 (rank : 53)	NC score	0.447209 (rank : 68)
Query Neighborhood Hits	219	Target Neighborhood Hits	404	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG7_MOUSE
θ value	2.69671e-12 (rank : 54)	NC score	0.476580 (rank : 59)
Query Neighborhood Hits	219	Target Neighborhood Hits	396	Shared Neighborhood Hits	79
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ZFY16_HUMAN
θ value	3.52202e-12 (rank : 55)	NC score	0.465681 (rank : 63)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ARHG6_HUMAN
θ value	4.59992e-12 (rank : 56)	NC score	0.428815 (rank : 72)
Query Neighborhood Hits	219	Target Neighborhood Hits	376	Shared Neighborhood Hits	78
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ZFYV9_HUMAN
θ value	4.59992e-12 (rank : 57)	NC score	0.485848 (rank : 57)
Query Neighborhood Hits	219	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

VAV2_HUMAN
θ value	7.84624e-12 (rank : 58)	NC score	0.450989 (rank : 67)
Query Neighborhood Hits	219	Target Neighborhood Hits	453	Shared Neighborhood Hits	83
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ZFY16_MOUSE
θ value	7.84624e-12 (rank : 59)	NC score	0.473666 (rank : 61)
Query Neighborhood Hits	219	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ARHGA_HUMAN
θ value	1.33837e-11 (rank : 60)	NC score	0.599869 (rank : 31)
Query Neighborhood Hits	219	Target Neighborhood Hits	187	Shared Neighborhood Hits	75
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG2_HUMAN
θ value	1.74796e-11 (rank : 61)	NC score	0.521134 (rank : 50)
Query Neighborhood Hits	219	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

VAV_HUMAN
θ value	1.74796e-11 (rank : 62)	NC score	0.455638 (rank : 66)
Query Neighborhood Hits	219	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHGA_MOUSE
θ value	2.28291e-11 (rank : 63)	NC score	0.593477 (rank : 33)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	71
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PKHG4_HUMAN
θ value	2.28291e-11 (rank : 64)	NC score	0.507535 (rank : 53)
Query Neighborhood Hits	219	Target Neighborhood Hits	200	Shared Neighborhood Hits	56
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZFY28_HUMAN
θ value	3.89403e-11 (rank : 65)	NC score	0.499572 (rank : 54)
Query Neighborhood Hits	219	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

BCR_HUMAN
θ value	5.08577e-11 (rank : 66)	NC score	0.423895 (rank : 73)
Query Neighborhood Hits	219	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

VAV_MOUSE
θ value	6.64225e-11 (rank : 67)	NC score	0.462085 (rank : 64)
Query Neighborhood Hits	219	Target Neighborhood Hits	430	Shared Neighborhood Hits	74
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHGB_HUMAN
θ value	1.47974e-10 (rank : 68)	NC score	0.540524 (rank : 45)
Query Neighborhood Hits	219	Target Neighborhood Hits	375	Shared Neighborhood Hits	78
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG3_HUMAN
θ value	7.34386e-10 (rank : 69)	NC score	0.549362 (rank : 42)
Query Neighborhood Hits	219	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

OBSCN_HUMAN
θ value	7.34386e-10 (rank : 70)	NC score	0.103507 (rank : 129)
Query Neighborhood Hits	219	Target Neighborhood Hits	1931	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FYCO1_HUMAN
θ value	1.63604e-09 (rank : 71)	NC score	0.199901 (rank : 106)
Query Neighborhood Hits	219	Target Neighborhood Hits	1149	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ARHG3_MOUSE
θ value	3.64472e-09 (rank : 72)	NC score	0.549770 (rank : 41)
Query Neighborhood Hits	219	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

RUFY1_MOUSE
θ value	4.76016e-09 (rank : 73)	NC score	0.281405 (rank : 96)
Query Neighborhood Hits	219	Target Neighborhood Hits	765	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	4.76016e-09 (rank : 74)	NC score	0.237010 (rank : 103)
Query Neighborhood Hits	219	Target Neighborhood Hits	1208	Shared Neighborhood Hits	84
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SOS2_HUMAN
θ value	4.76016e-09 (rank : 75)	NC score	0.326115 (rank : 88)
Query Neighborhood Hits	219	Target Neighborhood Hits	193	Shared Neighborhood Hits	48
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

RUFY1_HUMAN
θ value	6.21693e-09 (rank : 76)	NC score	0.277905 (rank : 97)
Query Neighborhood Hits	219	Target Neighborhood Hits	848	Shared Neighborhood Hits	84
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SOS1_HUMAN
θ value	6.21693e-09 (rank : 77)	NC score	0.327510 (rank : 87)
Query Neighborhood Hits	219	Target Neighborhood Hits	274	Shared Neighborhood Hits	47
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

EEA1_HUMAN
θ value	8.11959e-09 (rank : 78)	NC score	0.179626 (rank : 109)
Query Neighborhood Hits	219	Target Neighborhood Hits	1796	Shared Neighborhood Hits	98
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

RUFY2_MOUSE
θ value	8.11959e-09 (rank : 79)	NC score	0.283950 (rank : 95)
Query Neighborhood Hits	219	Target Neighborhood Hits	820	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

MCF2_HUMAN
θ value	1.06045e-08 (rank : 80)	NC score	0.594274 (rank : 32)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

EEA1_MOUSE
θ value	4.0297e-08 (rank : 81)	NC score	0.192221 (rank : 107)
Query Neighborhood Hits	219	Target Neighborhood Hits	1637	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SOS1_MOUSE
θ value	4.0297e-08 (rank : 82)	NC score	0.308058 (rank : 93)
Query Neighborhood Hits	219	Target Neighborhood Hits	281	Shared Neighborhood Hits	45
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TIAM1_MOUSE
θ value	4.0297e-08 (rank : 83)	NC score	0.569418 (rank : 36)
Query Neighborhood Hits	219	Target Neighborhood Hits	205	Shared Neighborhood Hits	78
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

HGS_HUMAN
θ value	6.87365e-08 (rank : 84)	NC score	0.372913 (rank : 81)
Query Neighborhood Hits	219	Target Neighborhood Hits	517	Shared Neighborhood Hits	65
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	8.97725e-08 (rank : 85)	NC score	0.372629 (rank : 82)
Query Neighborhood Hits	219	Target Neighborhood Hits	589	Shared Neighborhood Hits	68
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

WDFY3_HUMAN
θ value	1.17247e-07 (rank : 86)	NC score	0.269028 (rank : 99)
Query Neighborhood Hits	219	Target Neighborhood Hits	348	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

ARHG6_MOUSE
θ value	1.99992e-07 (rank : 87)	NC score	0.398262 (rank : 80)
Query Neighborhood Hits	219	Target Neighborhood Hits	394	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

TIAM1_HUMAN
θ value	1.99992e-07 (rank : 88)	NC score	0.565970 (rank : 38)
Query Neighborhood Hits	219	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

WDFY3_MOUSE
θ value	1.99992e-07 (rank : 89)	NC score	0.269293 (rank : 98)
Query Neighborhood Hits	219	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

MCF2L_MOUSE
θ value	2.61198e-07 (rank : 90)	NC score	0.557293 (rank : 40)
Query Neighborhood Hits	219	Target Neighborhood Hits	255	Shared Neighborhood Hits	81
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

WDFY1_HUMAN
θ value	4.45536e-07 (rank : 91)	NC score	0.285445 (rank : 94)
Query Neighborhood Hits	219	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ARHG8_MOUSE
θ value	1.29631e-06 (rank : 92)	NC score	0.478971 (rank : 58)
Query Neighborhood Hits	219	Target Neighborhood Hits	79	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ZFY21_HUMAN
θ value	1.69304e-06 (rank : 93)	NC score	0.469718 (rank : 62)
Query Neighborhood Hits	219	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

MTMR3_HUMAN
θ value	2.88788e-06 (rank : 94)	NC score	0.254779 (rank : 102)
Query Neighborhood Hits	219	Target Neighborhood Hits	163	Shared Neighborhood Hits	49
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

ZFY21_MOUSE
θ value	2.88788e-06 (rank : 95)	NC score	0.475601 (rank : 60)
Query Neighborhood Hits	219	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FYCO1_MOUSE
θ value	4.92598e-06 (rank : 96)	NC score	0.185221 (rank : 108)
Query Neighborhood Hits	219	Target Neighborhood Hits	1059	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

WDFY2_HUMAN
θ value	6.43352e-06 (rank : 97)	NC score	0.262861 (rank : 101)
Query Neighborhood Hits	219	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	6.43352e-06 (rank : 98)	NC score	0.264805 (rank : 100)
Query Neighborhood Hits	219	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FYV1_HUMAN
θ value	1.09739e-05 (rank : 99)	NC score	0.314851 (rank : 90)
Query Neighborhood Hits	219	Target Neighborhood Hits	217	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	1.09739e-05 (rank : 100)	NC score	0.311621 (rank : 91)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ANFY1_HUMAN
θ value	4.1701e-05 (rank : 101)	NC score	0.174602 (rank : 112)
Query Neighborhood Hits	219	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
θ value	4.1701e-05 (rank : 102)	NC score	0.174748 (rank : 111)
Query Neighborhood Hits	219	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

RBNS5_MOUSE
θ value	4.1701e-05 (rank : 103)	NC score	0.351028 (rank : 85)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RBNS5_HUMAN
θ value	5.44631e-05 (rank : 104)	NC score	0.357836 (rank : 83)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ZFYV1_HUMAN
θ value	0.000270298 (rank : 105)	NC score	0.352226 (rank : 84)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	0.00035302 (rank : 106)	NC score	0.348820 (rank : 86)
Query Neighborhood Hits	219	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

DGKH_HUMAN
θ value	0.000786445 (rank : 107)	NC score	0.093342 (rank : 140)
Query Neighborhood Hits	219	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MYH9_MOUSE
θ value	0.00102713 (rank : 108)	NC score	0.038794 (rank : 330)
Query Neighborhood Hits	219	Target Neighborhood Hits	1829	Shared Neighborhood Hits	66
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

DNMBP_MOUSE
θ value	0.00134147 (rank : 109)	NC score	0.430739 (rank : 71)
Query Neighborhood Hits	219	Target Neighborhood Hits	435	Shared Neighborhood Hits	74
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MYH9_HUMAN
θ value	0.00134147 (rank : 110)	NC score	0.040134 (rank : 327)
Query Neighborhood Hits	219	Target Neighborhood Hits	1762	Shared Neighborhood Hits	66
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

DNMBP_HUMAN
θ value	0.00298849 (rank : 111)	NC score	0.413231 (rank : 76)
Query Neighborhood Hits	219	Target Neighborhood Hits	413	Shared Neighborhood Hits	81
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SNX23_HUMAN
θ value	0.00665767 (rank : 112)	NC score	0.034242 (rank : 340)
Query Neighborhood Hits	219	Target Neighborhood Hits	944	Shared Neighborhood Hits	46
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

ZFY19_HUMAN
θ value	0.00665767 (rank : 113)	NC score	0.316856 (rank : 89)
Query Neighborhood Hits	219	Target Neighborhood Hits	206	Shared Neighborhood Hits	47
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

CENB2_HUMAN
θ value	0.00869519 (rank : 114)	NC score	0.062558 (rank : 220)
Query Neighborhood Hits	219	Target Neighborhood Hits	425	Shared Neighborhood Hits	52
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

ZFY19_MOUSE
θ value	0.00869519 (rank : 115)	NC score	0.309315 (rank : 92)
Query Neighborhood Hits	219	Target Neighborhood Hits	143	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

CYH3_MOUSE
θ value	0.0193708 (rank : 116)	NC score	0.095187 (rank : 137)
Query Neighborhood Hits	219	Target Neighborhood Hits	148	Shared Neighborhood Hits	46
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

DGKD_HUMAN
θ value	0.0252991 (rank : 117)	NC score	0.076204 (rank : 176)
Query Neighborhood Hits	219	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

SWP70_HUMAN
θ value	0.0330416 (rank : 118)	NC score	0.109993 (rank : 124)
Query Neighborhood Hits	219	Target Neighborhood Hits	973	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

OSBL9_HUMAN
θ value	0.0431538 (rank : 119)	NC score	0.077293 (rank : 172)
Query Neighborhood Hits	219	Target Neighborhood Hits	138	Shared Neighborhood Hits	37
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

IQEC3_HUMAN
θ value	0.0563607 (rank : 120)	NC score	0.060622 (rank : 227)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

SWP70_MOUSE
θ value	0.0563607 (rank : 121)	NC score	0.106134 (rank : 125)
Query Neighborhood Hits	219	Target Neighborhood Hits	1097	Shared Neighborhood Hits	93
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CTRO_MOUSE
θ value	0.0961366 (rank : 122)	NC score	0.028312 (rank : 346)
Query Neighborhood Hits	219	Target Neighborhood Hits	2344	Shared Neighborhood Hits	67
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ZCH13_HUMAN
θ value	0.0961366 (rank : 123)	NC score	0.045079 (rank : 316)
Query Neighborhood Hits	219	Target Neighborhood Hits	151	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WW36	Gene names	ZCCHC13
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 13.

MYRIP_MOUSE
θ value	0.125558 (rank : 124)	NC score	0.079618 (rank : 161)
Query Neighborhood Hits	219	Target Neighborhood Hits	207	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NC6IP_MOUSE
θ value	0.163984 (rank : 125)	NC score	0.021979 (rank : 352)
Query Neighborhood Hits	219	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

BMX_HUMAN
θ value	0.21417 (rank : 126)	NC score	0.008264 (rank : 366)
Query Neighborhood Hits	219	Target Neighborhood Hits	942	Shared Neighborhood Hits	32
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

DP13B_HUMAN
θ value	0.21417 (rank : 127)	NC score	0.048296 (rank : 314)
Query Neighborhood Hits	219	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

EVI1_HUMAN
θ value	0.21417 (rank : 128)	NC score	-0.002007 (rank : 377)
Query Neighborhood Hits	219	Target Neighborhood Hits	924	Shared Neighborhood Hits	14
SwissProt Accessions	Q03112, Q16122, Q99917	Gene names	EVI1
Domain Architecture
Description	Ecotropic virus integration 1 site protein.

CYH4_MOUSE
θ value	0.279714 (rank : 129)	NC score	0.085099 (rank : 151)
Query Neighborhood Hits	219	Target Neighborhood Hits	134	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DGKK_HUMAN
θ value	0.279714 (rank : 130)	NC score	0.060611 (rank : 229)
Query Neighborhood Hits	219	Target Neighborhood Hits	378	Shared Neighborhood Hits	31
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

IQEC3_MOUSE
θ value	0.279714 (rank : 131)	NC score	0.052798 (rank : 286)
Query Neighborhood Hits	219	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CENB1_HUMAN
θ value	0.365318 (rank : 132)	NC score	0.048762 (rank : 312)
Query Neighborhood Hits	219	Target Neighborhood Hits	383	Shared Neighborhood Hits	41
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CYH3_HUMAN
θ value	0.365318 (rank : 133)	NC score	0.076868 (rank : 174)
Query Neighborhood Hits	219	Target Neighborhood Hits	137	Shared Neighborhood Hits	41
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

MELPH_MOUSE
θ value	0.365318 (rank : 134)	NC score	0.082592 (rank : 155)
Query Neighborhood Hits	219	Target Neighborhood Hits	112	Shared Neighborhood Hits	18
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

CYH4_HUMAN
θ value	0.47712 (rank : 135)	NC score	0.078814 (rank : 163)
Query Neighborhood Hits	219	Target Neighborhood Hits	135	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

HKR1_HUMAN
θ value	0.47712 (rank : 136)	NC score	-0.005591 (rank : 381)
Query Neighborhood Hits	219	Target Neighborhood Hits	759	Shared Neighborhood Hits	7
SwissProt Accessions	P10072, Q9BSW9, Q9UM09	Gene names	HKR1
Domain Architecture
Description	Krueppel-related zinc finger protein 1 (Protein HKR1).

K1914_HUMAN
θ value	0.47712 (rank : 137)	NC score	0.055816 (rank : 263)
Query Neighborhood Hits	219	Target Neighborhood Hits	255	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MCM4_HUMAN
θ value	0.47712 (rank : 138)	NC score	0.014420 (rank : 359)
Query Neighborhood Hits	219	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MYRIP_HUMAN
θ value	0.47712 (rank : 139)	NC score	0.064887 (rank : 213)
Query Neighborhood Hits	219	Target Neighborhood Hits	269	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

CENB5_HUMAN
θ value	0.62314 (rank : 140)	NC score	0.060503 (rank : 231)
Query Neighborhood Hits	219	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CYH1_HUMAN
θ value	0.62314 (rank : 141)	NC score	0.077990 (rank : 168)
Query Neighborhood Hits	219	Target Neighborhood Hits	184	Shared Neighborhood Hits	52
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

MD1L1_MOUSE
θ value	0.62314 (rank : 142)	NC score	0.051660 (rank : 291)
Query Neighborhood Hits	219	Target Neighborhood Hits	1001	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MELPH_HUMAN
θ value	0.62314 (rank : 143)	NC score	0.072728 (rank : 190)
Query Neighborhood Hits	219	Target Neighborhood Hits	145	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

DESP_HUMAN
θ value	0.813845 (rank : 144)	NC score	0.049027 (rank : 310)
Query Neighborhood Hits	219	Target Neighborhood Hits	1470	Shared Neighborhood Hits	56
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

CYH2_HUMAN
θ value	1.06291 (rank : 145)	NC score	0.073835 (rank : 183)
Query Neighborhood Hits	219	Target Neighborhood Hits	175	Shared Neighborhood Hits	46
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	1.06291 (rank : 146)	NC score	0.073825 (rank : 184)
Query Neighborhood Hits	219	Target Neighborhood Hits	171	Shared Neighborhood Hits	46
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

3BP2_HUMAN
θ value	1.38821 (rank : 147)	NC score	0.073586 (rank : 186)
Query Neighborhood Hits	219	Target Neighborhood Hits	296	Shared Neighborhood Hits	30
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ALS2_HUMAN
θ value	1.38821 (rank : 148)	NC score	0.104029 (rank : 128)
Query Neighborhood Hits	219	Target Neighborhood Hits	121	Shared Neighborhood Hits	25
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CEND1_MOUSE
θ value	1.38821 (rank : 149)	NC score	0.049601 (rank : 308)
Query Neighborhood Hits	219	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CN094_HUMAN
θ value	1.38821 (rank : 150)	NC score	0.025951 (rank : 349)
Query Neighborhood Hits	219	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H6D7, Q86T15, Q86T16, Q86U43, Q9NX59	Gene names	C14orf94
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf94.

CYH1_MOUSE
θ value	1.38821 (rank : 151)	NC score	0.075119 (rank : 180)
Query Neighborhood Hits	219	Target Neighborhood Hits	176	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DP13B_MOUSE
θ value	1.38821 (rank : 152)	NC score	0.043076 (rank : 322)
Query Neighborhood Hits	219	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

K1914_MOUSE
θ value	1.38821 (rank : 153)	NC score	0.038883 (rank : 329)
Query Neighborhood Hits	219	Target Neighborhood Hits	216	Shared Neighborhood Hits	21
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

NOLC1_HUMAN
θ value	1.38821 (rank : 154)	NC score	0.010288 (rank : 363)
Query Neighborhood Hits	219	Target Neighborhood Hits	452	Shared Neighborhood Hits	9
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

TXLNA_HUMAN
θ value	1.38821 (rank : 155)	NC score	0.040516 (rank : 326)
Query Neighborhood Hits	219	Target Neighborhood Hits	982	Shared Neighborhood Hits	42
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

BMX_MOUSE
θ value	1.81305 (rank : 156)	NC score	0.006412 (rank : 369)
Query Neighborhood Hits	219	Target Neighborhood Hits	912	Shared Neighborhood Hits	28
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CENA1_HUMAN
θ value	1.81305 (rank : 157)	NC score	0.041150 (rank : 325)
Query Neighborhood Hits	219	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

GOGA4_MOUSE
θ value	1.81305 (rank : 158)	NC score	0.044291 (rank : 317)
Query Neighborhood Hits	219	Target Neighborhood Hits	1939	Shared Neighborhood Hits	67
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

KMHN1_HUMAN
θ value	1.81305 (rank : 159)	NC score	0.049385 (rank : 309)
Query Neighborhood Hits	219	Target Neighborhood Hits	950	Shared Neighborhood Hits	49
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

NHLC1_MOUSE
θ value	1.81305 (rank : 160)	NC score	0.053463 (rank : 281)
Query Neighborhood Hits	219	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

PARN_MOUSE
θ value	1.81305 (rank : 161)	NC score	0.019195 (rank : 355)
Query Neighborhood Hits	219	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDG3, Q8C7N6, Q9DC46	Gene names	Parn
Domain Architecture	No domain graphic available
Description	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate- specific ribonuclease).

PKHA2_HUMAN
θ value	1.81305 (rank : 162)	NC score	0.076167 (rank : 177)
Query Neighborhood Hits	219	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RASA2_MOUSE
θ value	1.81305 (rank : 163)	NC score	0.032680 (rank : 341)
Query Neighborhood Hits	219	Target Neighborhood Hits	159	Shared Neighborhood Hits	29
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_MOUSE
θ value	1.81305 (rank : 164)	NC score	0.030158 (rank : 344)
Query Neighborhood Hits	219	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

TXLNA_MOUSE
θ value	1.81305 (rank : 165)	NC score	0.043613 (rank : 320)
Query Neighborhood Hits	219	Target Neighborhood Hits	846	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

BPA1_MOUSE
θ value	2.36792 (rank : 166)	NC score	0.039282 (rank : 328)
Query Neighborhood Hits	219	Target Neighborhood Hits	1477	Shared Neighborhood Hits	54
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

HS90A_MOUSE
θ value	2.36792 (rank : 167)	NC score	0.008450 (rank : 365)
Query Neighborhood Hits	219	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	P07901	Gene names	Hsp90aa1, Hsp86, Hsp86-1, Hspca
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (Tumor-specific transplantation 86 kDa antigen) (TSTA).

MYH8_HUMAN
θ value	2.36792 (rank : 168)	NC score	0.035520 (rank : 334)
Query Neighborhood Hits	219	Target Neighborhood Hits	1610	Shared Neighborhood Hits	64
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PARN_HUMAN
θ value	2.36792 (rank : 169)	NC score	0.018263 (rank : 356)
Query Neighborhood Hits	219	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O95453	Gene names	PARN, DAN
Domain Architecture	No domain graphic available
Description	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate- specific ribonuclease) (Deadenylating nuclease) (Deadenylation nuclease).

SYTL4_HUMAN
θ value	2.36792 (rank : 170)	NC score	0.044262 (rank : 318)
Query Neighborhood Hits	219	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

3BP2_MOUSE
θ value	3.0926 (rank : 171)	NC score	0.068505 (rank : 202)
Query Neighborhood Hits	219	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

DDEF2_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.067672 (rank : 205)
Query Neighborhood Hits	219	Target Neighborhood Hits	599	Shared Neighborhood Hits	52
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	3.0926 (rank : 173)	NC score	0.067935 (rank : 204)
Query Neighborhood Hits	219	Target Neighborhood Hits	625	Shared Neighborhood Hits	52
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NHLC1_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.043181 (rank : 321)
Query Neighborhood Hits	219	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

PKHA2_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.082753 (rank : 154)
Query Neighborhood Hits	219	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CCD94_HUMAN
θ value	4.03905 (rank : 176)	NC score	0.027094 (rank : 348)
Query Neighborhood Hits	219	Target Neighborhood Hits	139	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BW85, O75270, Q9H862, Q9NW16	Gene names	CCDC94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

CTRO_HUMAN
θ value	4.03905 (rank : 177)	NC score	0.023359 (rank : 351)
Query Neighborhood Hits	219	Target Neighborhood Hits	2092	Shared Neighborhood Hits	63
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DDFL1_HUMAN
θ value	4.03905 (rank : 178)	NC score	0.027540 (rank : 347)
Query Neighborhood Hits	219	Target Neighborhood Hits	353	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

TACC2_HUMAN
θ value	4.03905 (rank : 179)	NC score	0.035508 (rank : 335)
Query Neighborhood Hits	219	Target Neighborhood Hits	856	Shared Neighborhood Hits	46
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

CCD94_MOUSE
θ value	5.27518 (rank : 180)	NC score	0.034281 (rank : 339)
Query Neighborhood Hits	219	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D6J3	Gene names	Ccdc94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

CNKR1_HUMAN
θ value	5.27518 (rank : 181)	NC score	0.080483 (rank : 157)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	30
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

EZH2_HUMAN
θ value	5.27518 (rank : 182)	NC score	0.005645 (rank : 370)
Query Neighborhood Hits	219	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

KMHN1_MOUSE
θ value	5.27518 (rank : 183)	NC score	0.050090 (rank : 307)
Query Neighborhood Hits	219	Target Neighborhood Hits	949	Shared Neighborhood Hits	52
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

MYH1_HUMAN
θ value	5.27518 (rank : 184)	NC score	0.035369 (rank : 337)
Query Neighborhood Hits	219	Target Neighborhood Hits	1478	Shared Neighborhood Hits	59
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH2_HUMAN
θ value	5.27518 (rank : 185)	NC score	0.034387 (rank : 338)
Query Neighborhood Hits	219	Target Neighborhood Hits	1491	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

NP1L3_MOUSE
θ value	5.27518 (rank : 186)	NC score	0.009075 (rank : 364)
Query Neighborhood Hits	219	Target Neighborhood Hits	233	Shared Neighborhood Hits	12
SwissProt Accessions	Q794H2, O54802	Gene names	Nap1l3, Mb20
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20).

OSBL8_HUMAN
θ value	5.27518 (rank : 187)	NC score	0.013151 (rank : 360)
Query Neighborhood Hits	219	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PCDG5_HUMAN
θ value	5.27518 (rank : 188)	NC score	-0.002557 (rank : 378)
Query Neighborhood Hits	219	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5G8, Q9Y5D2	Gene names	PCDHGA5
Domain Architecture
Description	Protocadherin gamma A5 precursor (PCDH-gamma-A5).

PRD16_HUMAN
θ value	5.27518 (rank : 189)	NC score	-0.005019 (rank : 380)
Query Neighborhood Hits	219	Target Neighborhood Hits	832	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HAZ2, Q8WYJ9, Q9C0I8	Gene names	PRDM16, KIAA1675, MEL1, PFM13
Domain Architecture
Description	PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1).

RGS3_HUMAN
θ value	5.27518 (rank : 190)	NC score	0.025245 (rank : 350)
Query Neighborhood Hits	219	Target Neighborhood Hits	1375	Shared Neighborhood Hits	40
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RGS3_MOUSE
θ value	5.27518 (rank : 191)	NC score	0.038395 (rank : 331)
Query Neighborhood Hits	219	Target Neighborhood Hits	1621	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SYCP1_MOUSE
θ value	5.27518 (rank : 192)	NC score	0.042296 (rank : 323)
Query Neighborhood Hits	219	Target Neighborhood Hits	1456	Shared Neighborhood Hits	62
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYTL4_MOUSE
θ value	5.27518 (rank : 193)	NC score	0.031807 (rank : 342)
Query Neighborhood Hits	219	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

CEND1_HUMAN
θ value	6.88961 (rank : 194)	NC score	0.050841 (rank : 299)
Query Neighborhood Hits	219	Target Neighborhood Hits	284	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CENG2_MOUSE
θ value	6.88961 (rank : 195)	NC score	0.015968 (rank : 358)
Query Neighborhood Hits	219	Target Neighborhood Hits	463	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CYTSA_HUMAN
θ value	6.88961 (rank : 196)	NC score	0.041534 (rank : 324)
Query Neighborhood Hits	219	Target Neighborhood Hits	1138	Shared Neighborhood Hits	50
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

EXOC3_HUMAN
θ value	6.88961 (rank : 197)	NC score	0.012693 (rank : 361)
Query Neighborhood Hits	219	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	O60645, Q8TEN6, Q8WUW0, Q96DI4	Gene names	EXOC3, SEC6, SEC6L1
Domain Architecture
Description	Exocyst complex component 3 (Exocyst complex component Sec6).

EZH2_MOUSE
θ value	6.88961 (rank : 198)	NC score	0.005237 (rank : 371)
Query Neighborhood Hits	219	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

FLIP1_HUMAN
θ value	6.88961 (rank : 199)	NC score	0.048460 (rank : 313)
Query Neighborhood Hits	219	Target Neighborhood Hits	1405	Shared Neighborhood Hits	57
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

MEFV_HUMAN
θ value	6.88961 (rank : 200)	NC score	0.001269 (rank : 373)
Query Neighborhood Hits	219	Target Neighborhood Hits	431	Shared Neighborhood Hits	18
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

PKN2_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.000260 (rank : 376)
Query Neighborhood Hits	219	Target Neighborhood Hits	892	Shared Neighborhood Hits	13
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SRP68_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.010295 (rank : 362)
Query Neighborhood Hits	219	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UHB9, Q8NCJ4, Q8WUK2	Gene names	SRP68
Domain Architecture	No domain graphic available
Description	Signal recognition particle 68 kDa protein (SRP68).

3BP1_MOUSE
θ value	8.99809 (rank : 203)	NC score	0.020226 (rank : 354)
Query Neighborhood Hits	219	Target Neighborhood Hits	238	Shared Neighborhood Hits	13
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CEND2_HUMAN
θ value	8.99809 (rank : 204)	NC score	0.036948 (rank : 332)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CYLD_HUMAN
θ value	8.99809 (rank : 205)	NC score	0.008065 (rank : 367)
Query Neighborhood Hits	219	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

CYLD_MOUSE
θ value	8.99809 (rank : 206)	NC score	0.007275 (rank : 368)
Query Neighborhood Hits	219	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

EVI1_MOUSE
θ value	8.99809 (rank : 207)	NC score	-0.004412 (rank : 379)
Query Neighborhood Hits	219	Target Neighborhood Hits	826	Shared Neighborhood Hits	12
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

EXOC8_MOUSE
θ value	8.99809 (rank : 208)	NC score	0.018044 (rank : 357)
Query Neighborhood Hits	219	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PGF7	Gene names	Exoc8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

FLIP1_MOUSE
θ value	8.99809 (rank : 209)	NC score	0.043723 (rank : 319)
Query Neighborhood Hits	219	Target Neighborhood Hits	1176	Shared Neighborhood Hits	54
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA4_HUMAN
θ value	8.99809 (rank : 210)	NC score	0.048807 (rank : 311)
Query Neighborhood Hits	219	Target Neighborhood Hits	2034	Shared Neighborhood Hits	73
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GOGB1_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.045871 (rank : 315)
Query Neighborhood Hits	219	Target Neighborhood Hits	2297	Shared Neighborhood Hits	76
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

KCNH1_HUMAN
θ value	8.99809 (rank : 212)	NC score	0.000368 (rank : 375)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

MYH10_HUMAN
θ value	8.99809 (rank : 213)	NC score	0.035537 (rank : 333)
Query Neighborhood Hits	219	Target Neighborhood Hits	1620	Shared Neighborhood Hits	60
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	8.99809 (rank : 214)	NC score	0.035414 (rank : 336)
Query Neighborhood Hits	219	Target Neighborhood Hits	1612	Shared Neighborhood Hits	60
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH4_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.031017 (rank : 343)
Query Neighborhood Hits	219	Target Neighborhood Hits	1377	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

PPAL_HUMAN
θ value	8.99809 (rank : 216)	NC score	0.004439 (rank : 372)
Query Neighborhood Hits	219	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P11117, Q9BTU7	Gene names	ACP2
Domain Architecture
Description	Lysosomal acid phosphatase precursor (EC 3.1.3.2) (LAP).

RASA3_HUMAN
θ value	8.99809 (rank : 217)	NC score	0.029050 (rank : 345)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	37
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SOX12_MOUSE
θ value	8.99809 (rank : 218)	NC score	0.000781 (rank : 374)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q04890, P70417, Q6NXL2	Gene names	Sox12, Sox-12
Domain Architecture	No domain graphic available
Description	SOX-12 protein.

SYTL5_MOUSE
θ value	8.99809 (rank : 219)	NC score	0.021596 (rank : 353)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	19
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

41_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.059688 (rank : 235)
Query Neighborhood Hits	219	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.058005 (rank : 245)
Query Neighborhood Hits	219	Target Neighborhood Hits	184	Shared Neighborhood Hits	5
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABI1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.072074 (rank : 193)
Query Neighborhood Hits	219	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.076983 (rank : 173)
Query Neighborhood Hits	219	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.080106 (rank : 158)
Query Neighborhood Hits	219	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.079865 (rank : 159)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.069190 (rank : 200)
Query Neighborhood Hits	219	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.067154 (rank : 207)
Query Neighborhood Hits	219	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.073152 (rank : 189)
Query Neighborhood Hits	219	Target Neighborhood Hits	537	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.066750 (rank : 208)
Query Neighborhood Hits	219	Target Neighborhood Hits	496	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALS2_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.119702 (rank : 118)
Query Neighborhood Hits	219	Target Neighborhood Hits	111	Shared Neighborhood Hits	25
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ANM2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.057321 (rank : 254)
Query Neighborhood Hits	219	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.053453 (rank : 282)
Query Neighborhood Hits	219	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG8_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.533063 (rank : 48)
Query Neighborhood Hits	219	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ASPP1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.050251 (rank : 305)
Query Neighborhood Hits	219	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.058197 (rank : 244)
Query Neighborhood Hits	219	Target Neighborhood Hits	1244	Shared Neighborhood Hits	70
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAIP2_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.050114 (rank : 306)
Query Neighborhood Hits	219	Target Neighborhood Hits	185	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.055180 (rank : 267)
Query Neighborhood Hits	219	Target Neighborhood Hits	554	Shared Neighborhood Hits	29
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.056346 (rank : 259)
Query Neighborhood Hits	219	Target Neighborhood Hits	438	Shared Neighborhood Hits	29
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.080819 (rank : 156)
Query Neighborhood Hits	219	Target Neighborhood Hits	156	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.066396 (rank : 211)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CARD9_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.050340 (rank : 302)
Query Neighborhood Hits	219	Target Neighborhood Hits	602	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.115740 (rank : 119)
Query Neighborhood Hits	219	Target Neighborhood Hits	315	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.113753 (rank : 122)
Query Neighborhood Hits	219	Target Neighborhood Hits	336	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CEP63_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.050420 (rank : 301)
Query Neighborhood Hits	219	Target Neighborhood Hits	1005	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CNKR2_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.062441 (rank : 221)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.062774 (rank : 218)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRKL_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.073197 (rank : 188)
Query Neighborhood Hits	219	Target Neighborhood Hits	313	Shared Neighborhood Hits	22
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.071331 (rank : 196)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.066459 (rank : 209)
Query Neighborhood Hits	219	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.069603 (rank : 199)
Query Neighborhood Hits	219	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.053226 (rank : 284)
Query Neighborhood Hits	219	Target Neighborhood Hits	235	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.064607 (rank : 214)
Query Neighborhood Hits	219	Target Neighborhood Hits	244	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.061573 (rank : 224)
Query Neighborhood Hits	219	Target Neighborhood Hits	306	Shared Neighborhood Hits	25
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.057584 (rank : 252)
Query Neighborhood Hits	219	Target Neighborhood Hits	592	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

E41L1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.058568 (rank : 241)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.057941 (rank : 246)
Query Neighborhood Hits	219	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.057937 (rank : 247)
Query Neighborhood Hits	219	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.059568 (rank : 236)
Query Neighborhood Hits	219	Target Neighborhood Hits	459	Shared Neighborhood Hits	21
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.060927 (rank : 225)
Query Neighborhood Hits	219	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.058890 (rank : 239)
Query Neighborhood Hits	219	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.060612 (rank : 228)
Query Neighborhood Hits	219	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.054986 (rank : 271)
Query Neighborhood Hits	219	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.054330 (rank : 277)
Query Neighborhood Hits	219	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.061657 (rank : 223)
Query Neighborhood Hits	219	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.060590 (rank : 230)
Query Neighborhood Hits	219	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EFS_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.057810 (rank : 249)
Query Neighborhood Hits	219	Target Neighborhood Hits	389	Shared Neighborhood Hits	24
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EP15R_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.055996 (rank : 261)
Query Neighborhood Hits	219	Target Neighborhood Hits	1083	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.056114 (rank : 260)
Query Neighborhood Hits	219	Target Neighborhood Hits	1135	Shared Neighborhood Hits	51
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.054377 (rank : 276)
Query Neighborhood Hits	219	Target Neighborhood Hits	1021	Shared Neighborhood Hits	50
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.051424 (rank : 293)
Query Neighborhood Hits	219	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EZRI_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.053835 (rank : 279)
Query Neighborhood Hits	219	Target Neighborhood Hits	663	Shared Neighborhood Hits	40
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.053742 (rank : 280)
Query Neighborhood Hits	219	Target Neighborhood Hits	693	Shared Neighborhood Hits	40
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FNBP2_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.058347 (rank : 243)
Query Neighborhood Hits	219	Target Neighborhood Hits	432	Shared Neighborhood Hits	44
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.058808 (rank : 240)
Query Neighborhood Hits	219	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.059206 (rank : 237)
Query Neighborhood Hits	219	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GOGA3_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.055571 (rank : 265)
Query Neighborhood Hits	219	Target Neighborhood Hits	1437	Shared Neighborhood Hits	60
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GRAP2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.078540 (rank : 164)
Query Neighborhood Hits	219	Target Neighborhood Hits	304	Shared Neighborhood Hits	25
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.078124 (rank : 166)
Query Neighborhood Hits	219	Target Neighborhood Hits	297	Shared Neighborhood Hits	24
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.095153 (rank : 138)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.094334 (rank : 139)
Query Neighborhood Hits	219	Target Neighborhood Hits	309	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.084620 (rank : 152)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.084583 (rank : 153)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	25
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.071445 (rank : 195)
Query Neighborhood Hits	219	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.077883 (rank : 169)
Query Neighborhood Hits	219	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.077685 (rank : 171)
Query Neighborhood Hits	219	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

LASP1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.060484 (rank : 232)
Query Neighborhood Hits	219	Target Neighborhood Hits	293	Shared Neighborhood Hits	24
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.058918 (rank : 238)
Query Neighborhood Hits	219	Target Neighborhood Hits	297	Shared Neighborhood Hits	24
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LMO7_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.054401 (rank : 275)
Query Neighborhood Hits	219	Target Neighborhood Hits	507	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MERL_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.054823 (rank : 273)
Query Neighborhood Hits	219	Target Neighborhood Hits	532	Shared Neighborhood Hits	37
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.055047 (rank : 269)
Query Neighborhood Hits	219	Target Neighborhood Hits	524	Shared Neighborhood Hits	37
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MOES_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.057472 (rank : 253)
Query Neighborhood Hits	219	Target Neighborhood Hits	892	Shared Neighborhood Hits	48
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.057790 (rank : 250)
Query Neighborhood Hits	219	Target Neighborhood Hits	923	Shared Neighborhood Hits	46
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYLIP_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.050685 (rank : 300)
Query Neighborhood Hits	219	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.050863 (rank : 298)
Query Neighborhood Hits	219	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NCF1_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.123152 (rank : 116)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.114203 (rank : 121)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.103371 (rank : 130)
Query Neighborhood Hits	219	Target Neighborhood Hits	229	Shared Neighborhood Hits	28
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.091174 (rank : 145)
Query Neighborhood Hits	219	Target Neighborhood Hits	161	Shared Neighborhood Hits	21
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.091482 (rank : 143)
Query Neighborhood Hits	219	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.100552 (rank : 131)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.097023 (rank : 136)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.070679 (rank : 197)
Query Neighborhood Hits	219	Target Neighborhood Hits	457	Shared Neighborhood Hits	49
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.051506 (rank : 292)
Query Neighborhood Hits	219	Target Neighborhood Hits	420	Shared Neighborhood Hits	36
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NOXO1_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.055270 (rank : 266)
Query Neighborhood Hits	219	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.062625 (rank : 219)
Query Neighborhood Hits	219	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.052013 (rank : 289)
Query Neighborhood Hits	219	Target Neighborhood Hits	288	Shared Neighborhood Hits	31
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.061850 (rank : 222)
Query Neighborhood Hits	219	Target Neighborhood Hits	267	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.068035 (rank : 203)
Query Neighborhood Hits	219	Target Neighborhood Hits	466	Shared Neighborhood Hits	28
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.067668 (rank : 206)
Query Neighborhood Hits	219	Target Neighborhood Hits	467	Shared Neighborhood Hits	30
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.050266 (rank : 304)
Query Neighborhood Hits	219	Target Neighborhood Hits	479	Shared Neighborhood Hits	45
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PACN1_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.050994 (rank : 297)
Query Neighborhood Hits	219	Target Neighborhood Hits	320	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.051411 (rank : 294)
Query Neighborhood Hits	219	Target Neighborhood Hits	283	Shared Neighborhood Hits	31
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.057846 (rank : 248)
Query Neighborhood Hits	219	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.058380 (rank : 242)
Query Neighborhood Hits	219	Target Neighborhood Hits	382	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.055640 (rank : 264)
Query Neighborhood Hits	219	Target Neighborhood Hits	385	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.055163 (rank : 268)
Query Neighborhood Hits	219	Target Neighborhood Hits	380	Shared Neighborhood Hits	39
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.054987 (rank : 270)
Query Neighborhood Hits	219	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.056431 (rank : 258)
Query Neighborhood Hits	219	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA1_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.051239 (rank : 295)
Query Neighborhood Hits	219	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA4_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.099082 (rank : 135)
Query Neighborhood Hits	219	Target Neighborhood Hits	283	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.100271 (rank : 132)
Query Neighborhood Hits	219	Target Neighborhood Hits	202	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.110192 (rank : 123)
Query Neighborhood Hits	219	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.160102 (rank : 114)
Query Neighborhood Hits	219	Target Neighborhood Hits	556	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.157021 (rank : 115)
Query Neighborhood Hits	219	Target Neighborhood Hits	591	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLCG1_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.073694 (rank : 185)
Query Neighborhood Hits	219	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.075172 (rank : 179)
Query Neighborhood Hits	219	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.062884 (rank : 217)
Query Neighborhood Hits	219	Target Neighborhood Hits	280	Shared Neighborhood Hits	22
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLEK_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.060749 (rank : 226)
Query Neighborhood Hits	219	Target Neighborhood Hits	110	Shared Neighborhood Hits	32
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.057647 (rank : 251)
Query Neighborhood Hits	219	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PPIP1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.079817 (rank : 160)
Query Neighborhood Hits	219	Target Neighborhood Hits	389	Shared Neighborhood Hits	45
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.078068 (rank : 167)
Query Neighborhood Hits	219	Target Neighborhood Hits	377	Shared Neighborhood Hits	44
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RADI_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.055942 (rank : 262)
Query Neighborhood Hits	219	Target Neighborhood Hits	741	Shared Neighborhood Hits	40
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.054979 (rank : 272)
Query Neighborhood Hits	219	Target Neighborhood Hits	773	Shared Neighborhood Hits	42
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

REPS1_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.051139 (rank : 296)
Query Neighborhood Hits	219	Target Neighborhood Hits	204	Shared Neighborhood Hits	17
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RFFL_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.054640 (rank : 274)
Query Neighborhood Hits	219	Target Neighborhood Hits	145	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFIP3_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.052985 (rank : 285)
Query Neighborhood Hits	219	Target Neighborhood Hits	1055	Shared Neighborhood Hits	57
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RGL1_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.051666 (rank : 290)
Query Neighborhood Hits	219	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.411450 (rank : 77)
Query Neighborhood Hits	219	Target Neighborhood Hits	641	Shared Neighborhood Hits	88
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG04_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.062992 (rank : 216)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.056993 (rank : 255)
Query Neighborhood Hits	219	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.056811 (rank : 257)
Query Neighborhood Hits	219	Target Neighborhood Hits	1479	Shared Neighborhood Hits	71
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.052759 (rank : 287)
Query Neighborhood Hits	219	Target Neighborhood Hits	1376	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RNF34_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.050268 (rank : 303)
Query Neighborhood Hits	219	Target Neighborhood Hits	153	Shared Neighborhood Hits	27
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.054124 (rank : 278)
Query Neighborhood Hits	219	Target Neighborhood Hits	160	Shared Neighborhood Hits	30
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RPGF1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.060409 (rank : 233)
Query Neighborhood Hits	219	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RUFY3_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.085998 (rank : 150)
Query Neighborhood Hits	219	Target Neighborhood Hits	594	Shared Neighborhood Hits	39
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.086498 (rank : 149)
Query Neighborhood Hits	219	Target Neighborhood Hits	579	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.074686 (rank : 181)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.070334 (rank : 198)
Query Neighborhood Hits	219	Target Neighborhood Hits	291	Shared Neighborhood Hits	28
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.074102 (rank : 182)
Query Neighborhood Hits	219	Target Neighborhood Hits	324	Shared Neighborhood Hits	35
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.071835 (rank : 194)
Query Neighborhood Hits	219	Target Neighborhood Hits	319	Shared Neighborhood Hits	35
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.073397 (rank : 187)
Query Neighborhood Hits	219	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.076087 (rank : 178)
Query Neighborhood Hits	219	Target Neighborhood Hits	236	Shared Neighborhood Hits	25
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.122845 (rank : 117)
Query Neighborhood Hits	219	Target Neighborhood Hits	341	Shared Neighborhood Hits	34
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.114295 (rank : 120)
Query Neighborhood Hits	219	Target Neighborhood Hits	332	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.060192 (rank : 234)
Query Neighborhood Hits	219	Target Neighborhood Hits	1041	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.072523 (rank : 191)
Query Neighborhood Hits	219	Target Neighborhood Hits	446	Shared Neighborhood Hits	32
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.065256 (rank : 212)
Query Neighborhood Hits	219	Target Neighborhood Hits	748	Shared Neighborhood Hits	64
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.064091 (rank : 215)
Query Neighborhood Hits	219	Target Neighborhood Hits	675	Shared Neighborhood Hits	55
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.072223 (rank : 192)
Query Neighborhood Hits	219	Target Neighborhood Hits	888	Shared Neighborhood Hits	65
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.104654 (rank : 127)
Query Neighborhood Hits	219	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.105280 (rank : 126)
Query Neighborhood Hits	219	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.077774 (rank : 170)
Query Neighborhood Hits	219	Target Neighborhood Hits	269	Shared Neighborhood Hits	27
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.076490 (rank : 175)
Query Neighborhood Hits	219	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.056836 (rank : 256)
Query Neighborhood Hits	219	Target Neighborhood Hits	390	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.052651 (rank : 288)
Query Neighborhood Hits	219	Target Neighborhood Hits	331	Shared Neighborhood Hits	37
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.053360 (rank : 283)
Query Neighborhood Hits	219	Target Neighborhood Hits	324	Shared Neighborhood Hits	38
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.078129 (rank : 165)
Query Neighborhood Hits	219	Target Neighborhood Hits	228	Shared Neighborhood Hits	25
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.079010 (rank : 162)
Query Neighborhood Hits	219	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.091436 (rank : 144)
Query Neighborhood Hits	219	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.088516 (rank : 148)
Query Neighborhood Hits	219	Target Neighborhood Hits	268	Shared Neighborhood Hits	27
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.092573 (rank : 141)
Query Neighborhood Hits	219	Target Neighborhood Hits	271	Shared Neighborhood Hits	27
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.091731 (rank : 142)
Query Neighborhood Hits	219	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.089752 (rank : 146)
Query Neighborhood Hits	219	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.089666 (rank : 147)
Query Neighborhood Hits	219	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.066399 (rank : 210)
Query Neighborhood Hits	219	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.068783 (rank : 201)
Query Neighborhood Hits	219	Target Neighborhood Hits	409	Shared Neighborhood Hits	38
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.099758 (rank : 133)
Query Neighborhood Hits	219	Target Neighborhood Hits	270	Shared Neighborhood Hits	29
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.099153 (rank : 134)
Query Neighborhood Hits	219	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY27_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.171529 (rank : 113)
Query Neighborhood Hits	219	Target Neighborhood Hits	64	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.177739 (rank : 110)
Query Neighborhood Hits	219	Target Neighborhood Hits	53	Shared Neighborhood Hits	40
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

Hits sorted by NC score

FGD4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	219	Target Neighborhood Hits	219	Shared Neighborhood Hits	219
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.993086 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	219	Target Neighborhood Hits	227	Shared Neighborhood Hits	174
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_HUMAN
NC score	0.975492 (rank : 3)	θ value	5.36813e-170 (rank : 5)
Query Neighborhood Hits	219	Target Neighborhood Hits	151	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
NC score	0.971939 (rank : 4)	θ value	3.25673e-167 (rank : 6)
Query Neighborhood Hits	219	Target Neighborhood Hits	163	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
NC score	0.957184 (rank : 5)	θ value	2.511e-143 (rank : 7)
Query Neighborhood Hits	219	Target Neighborhood Hits	249	Shared Neighborhood Hits	117
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD1_HUMAN
NC score	0.954965 (rank : 6)	θ value	1.0077e-184 (rank : 3)
Query Neighborhood Hits	219	Target Neighborhood Hits	367	Shared Neighborhood Hits	137
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.952679 (rank : 7)	θ value	5.00115e-184 (rank : 4)
Query Neighborhood Hits	219	Target Neighborhood Hits	387	Shared Neighborhood Hits	134
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_MOUSE
NC score	0.952578 (rank : 8)	θ value	1.02182e-136 (rank : 8)
Query Neighborhood Hits	219	Target Neighborhood Hits	257	Shared Neighborhood Hits	126
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD6_MOUSE
NC score	0.900326 (rank : 9)	θ value	3.81361e-83 (rank : 9)
Query Neighborhood Hits	219	Target Neighborhood Hits	282	Shared Neighborhood Hits	128
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.899175 (rank : 10)	θ value	2.73302e-81 (rank : 10)
Query Neighborhood Hits	219	Target Neighborhood Hits	237	Shared Neighborhood Hits	129
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
NC score	0.830400 (rank : 11)	θ value	4.84666e-62 (rank : 11)
Query Neighborhood Hits	219	Target Neighborhood Hits	235	Shared Neighborhood Hits	106
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.818578 (rank : 12)	θ value	1.97229e-55 (rank : 12)
Query Neighborhood Hits	219	Target Neighborhood Hits	170	Shared Neighborhood Hits	104
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PREX1_HUMAN
NC score	0.737396 (rank : 13)	θ value	2.35151e-24 (rank : 16)
Query Neighborhood Hits	219	Target Neighborhood Hits	177	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_MOUSE
NC score	0.730698 (rank : 14)	θ value	4.9032e-22 (rank : 17)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.717751 (rank : 15)	θ value	1.42661e-21 (rank : 18)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PKHG1_HUMAN
NC score	0.692430 (rank : 16)	θ value	2.88119e-14 (rank : 45)
Query Neighborhood Hits	219	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG5_HUMAN
NC score	0.670625 (rank : 17)	θ value	4.02038e-16 (rank : 34)
Query Neighborhood Hits	219	Target Neighborhood Hits	172	Shared Neighborhood Hits	74
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG4_MOUSE
NC score	0.669009 (rank : 18)	θ value	7.82807e-20 (rank : 21)
Query Neighborhood Hits	219	Target Neighborhood Hits	185	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHGG_HUMAN
NC score	0.656941 (rank : 19)	θ value	1.92812e-18 (rank : 25)
Query Neighborhood Hits	219	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.656668 (rank : 20)	θ value	4.58923e-20 (rank : 20)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_HUMAN
NC score	0.655094 (rank : 21)	θ value	7.0802e-21 (rank : 19)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NGEF_MOUSE
NC score	0.644496 (rank : 22)	θ value	2.27762e-19 (rank : 23)
Query Neighborhood Hits	219	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
NC score	0.638342 (rank : 23)	θ value	1.80466e-16 (rank : 31)
Query Neighborhood Hits	219	Target Neighborhood Hits	152	Shared Neighborhood Hits	70
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PKHF2_MOUSE
NC score	0.634891 (rank : 24)	θ value	5.60996e-18 (rank : 26)
Query Neighborhood Hits	219	Target Neighborhood Hits	77	Shared Neighborhood Hits	65
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ARHG9_HUMAN
NC score	0.634380 (rank : 25)	θ value	8.10077e-17 (rank : 30)
Query Neighborhood Hits	219	Target Neighborhood Hits	235	Shared Neighborhood Hits	73
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

PKHF2_HUMAN
NC score	0.634333 (rank : 26)	θ value	1.24977e-17 (rank : 29)
Query Neighborhood Hits	219	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ARHG9_MOUSE
NC score	0.633053 (rank : 27)	θ value	2.35696e-16 (rank : 33)
Query Neighborhood Hits	219	Target Neighborhood Hits	234	Shared Neighborhood Hits	73
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PKHF1_HUMAN
NC score	0.622515 (rank : 28)	θ value	8.95645e-16 (rank : 36)
Query Neighborhood Hits	219	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.619085 (rank : 29)	θ value	1.52774e-15 (rank : 37)
Query Neighborhood Hits	219	Target Neighborhood Hits	80	Shared Neighborhood Hits	63
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHGF_HUMAN
NC score	0.602395 (rank : 30)	θ value	5.25075e-16 (rank : 35)
Query Neighborhood Hits	219	Target Neighborhood Hits	214	Shared Neighborhood Hits	68
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGA_HUMAN
NC score	0.599869 (rank : 31)	θ value	1.33837e-11 (rank : 60)
Query Neighborhood Hits	219	Target Neighborhood Hits	187	Shared Neighborhood Hits	75
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2_HUMAN
NC score	0.594274 (rank : 32)	θ value	1.06045e-08 (rank : 80)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	81
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_MOUSE
NC score	0.593477 (rank : 33)	θ value	2.28291e-11 (rank : 63)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	71
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP2_MOUSE
NC score	0.586028 (rank : 34)	θ value	2.41655e-45 (rank : 14)
Query Neighborhood Hits	219	Target Neighborhood Hits	209	Shared Neighborhood Hits	98
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG2_MOUSE
NC score	0.577032 (rank : 35)	θ value	2.20605e-14 (rank : 44)
Query Neighborhood Hits	219	Target Neighborhood Hits	120	Shared Neighborhood Hits	65
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

TIAM1_MOUSE
NC score	0.569418 (rank : 36)	θ value	4.0297e-08 (rank : 83)
Query Neighborhood Hits	219	Target Neighborhood Hits	205	Shared Neighborhood Hits	78
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG1_HUMAN
NC score	0.566971 (rank : 37)	θ value	3.40345e-15 (rank : 41)
Query Neighborhood Hits	219	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

TIAM1_HUMAN
NC score	0.565970 (rank : 38)	θ value	1.99992e-07 (rank : 88)
Query Neighborhood Hits	219	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FARP2_HUMAN
NC score	0.565967 (rank : 39)	θ value	1.08474e-45 (rank : 13)
Query Neighborhood Hits	219	Target Neighborhood Hits	240	Shared Neighborhood Hits	96
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MCF2L_MOUSE
NC score	0.557293 (rank : 40)	θ value	2.61198e-07 (rank : 90)
Query Neighborhood Hits	219	Target Neighborhood Hits	255	Shared Neighborhood Hits	81
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG3_MOUSE
NC score	0.549770 (rank : 41)	θ value	3.64472e-09 (rank : 72)
Query Neighborhood Hits	219	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.549362 (rank : 42)	θ value	7.34386e-10 (rank : 69)
Query Neighborhood Hits	219	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

HAPIP_HUMAN
NC score	0.542060 (rank : 43)	θ value	1.80466e-16 (rank : 32)
Query Neighborhood Hits	219	Target Neighborhood Hits	350	Shared Neighborhood Hits	98
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG1_MOUSE
NC score	0.541446 (rank : 44)	θ value	1.99529e-15 (rank : 38)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
NC score	0.540524 (rank : 45)	θ value	1.47974e-10 (rank : 68)
Query Neighborhood Hits	219	Target Neighborhood Hits	375	Shared Neighborhood Hits	78
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FARP1_HUMAN
NC score	0.538661 (rank : 46)	θ value	8.89434e-40 (rank : 15)
Query Neighborhood Hits	219	Target Neighborhood Hits	241	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

LBC_HUMAN
NC score	0.538370 (rank : 47)	θ value	7.09661e-13 (rank : 51)
Query Neighborhood Hits	219	Target Neighborhood Hits	90	Shared Neighborhood Hits	58
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG8_HUMAN
NC score	0.533063 (rank : 48)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	219	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

GNRP_MOUSE
NC score	0.522744 (rank : 49)	θ value	8.38298e-14 (rank : 47)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	80
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG2_HUMAN
NC score	0.521134 (rank : 50)	θ value	1.74796e-11 (rank : 61)
Query Neighborhood Hits	219	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_HUMAN
NC score	0.519705 (rank : 51)	θ value	1.09485e-13 (rank : 48)
Query Neighborhood Hits	219	Target Neighborhood Hits	351	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.518857 (rank : 52)	θ value	1.42992e-13 (rank : 49)
Query Neighborhood Hits	219	Target Neighborhood Hits	344	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHG4_HUMAN
NC score	0.507535 (rank : 53)	θ value	2.28291e-11 (rank : 64)
Query Neighborhood Hits	219	Target Neighborhood Hits	200	Shared Neighborhood Hits	56
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ZFY28_HUMAN
NC score	0.499572 (rank : 54)	θ value	3.89403e-11 (rank : 65)
Query Neighborhood Hits	219	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ARHG7_HUMAN
NC score	0.496080 (rank : 55)	θ value	9.90251e-15 (rank : 43)
Query Neighborhood Hits	219	Target Neighborhood Hits	347	Shared Neighborhood Hits	79
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GNRP_HUMAN
NC score	0.489140 (rank : 56)	θ value	3.76295e-14 (rank : 46)
Query Neighborhood Hits	219	Target Neighborhood Hits	239	Shared Neighborhood Hits	83
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ZFYV9_HUMAN
NC score	0.485848 (rank : 57)	θ value	4.59992e-12 (rank : 57)
Query Neighborhood Hits	219	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ARHG8_MOUSE
NC score	0.478971 (rank : 58)	θ value	1.29631e-06 (rank : 92)
Query Neighborhood Hits	219	Target Neighborhood Hits	79	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG7_MOUSE
NC score	0.476580 (rank : 59)	θ value	2.69671e-12 (rank : 54)
Query Neighborhood Hits	219	Target Neighborhood Hits	396	Shared Neighborhood Hits	79
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ZFY21_MOUSE
NC score	0.475601 (rank : 60)	θ value	2.88788e-06 (rank : 95)
Query Neighborhood Hits	219	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_MOUSE
NC score	0.473666 (rank : 61)	θ value	7.84624e-12 (rank : 59)
Query Neighborhood Hits	219	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.469718 (rank : 62)	θ value	1.69304e-06 (rank : 93)
Query Neighborhood Hits	219	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.465681 (rank : 63)	θ value	3.52202e-12 (rank : 55)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	49
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

VAV_MOUSE
NC score	0.462085 (rank : 64)	θ value	6.64225e-11 (rank : 67)
Query Neighborhood Hits	219	Target Neighborhood Hits	430	Shared Neighborhood Hits	74
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
NC score	0.455829 (rank : 65)	θ value	7.09661e-13 (rank : 52)
Query Neighborhood Hits	219	Target Neighborhood Hits	456	Shared Neighborhood Hits	82
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
NC score	0.455638 (rank : 66)	θ value	1.74796e-11 (rank : 62)
Query Neighborhood Hits	219	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_HUMAN
NC score	0.450989 (rank : 67)	θ value	7.84624e-12 (rank : 58)
Query Neighborhood Hits	219	Target Neighborhood Hits	453	Shared Neighborhood Hits	83
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.447209 (rank : 68)	θ value	1.2105e-12 (rank : 53)
Query Neighborhood Hits	219	Target Neighborhood Hits	404	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.443832 (rank : 69)	θ value	4.16044e-13 (rank : 50)
Query Neighborhood Hits	219	Target Neighborhood Hits	398	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN2_HUMAN
NC score	0.438086 (rank : 70)	θ value	1.99529e-15 (rank : 39)
Query Neighborhood Hits	219	Target Neighborhood Hits	1173	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DNMBP_MOUSE
NC score	0.430739 (rank : 71)	θ value	0.00134147 (rank : 109)
Query Neighborhood Hits	219	Target Neighborhood Hits	435	Shared Neighborhood Hits	74
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_HUMAN
NC score	0.428815 (rank : 72)	θ value	4.59992e-12 (rank : 56)
Query Neighborhood Hits	219	Target Neighborhood Hits	376	Shared Neighborhood Hits	78
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

BCR_HUMAN
NC score	0.423895 (rank : 73)	θ value	5.08577e-11 (rank : 66)
Query Neighborhood Hits	219	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.422194 (rank : 74)	θ value	9.90251e-15 (rank : 42)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ITSN2_MOUSE
NC score	0.417585 (rank : 75)	θ value	1.99529e-15 (rank : 40)
Query Neighborhood Hits	219	Target Neighborhood Hits	1371	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DNMBP_HUMAN
NC score	0.413231 (rank : 76)	θ value	0.00298849 (rank : 111)
Query Neighborhood Hits	219	Target Neighborhood Hits	413	Shared Neighborhood Hits	81
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RGNEF_MOUSE
NC score	0.411450 (rank : 77)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	219	Target Neighborhood Hits	641	Shared Neighborhood Hits	88
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ITSN1_HUMAN
NC score	0.411135 (rank : 78)	θ value	1.33526e-19 (rank : 22)
Query Neighborhood Hits	219	Target Neighborhood Hits	1757	Shared Neighborhood Hits	117
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.409858 (rank : 79)	θ value	3.88503e-19 (rank : 24)
Query Neighborhood Hits	219	Target Neighborhood Hits	1669	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG6_MOUSE
NC score	0.398262 (rank : 80)	θ value	1.99992e-07 (rank : 87)
Query Neighborhood Hits	219	Target Neighborhood Hits	394	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

HGS_HUMAN
NC score	0.372913 (rank : 81)	θ value	6.87365e-08 (rank : 84)
Query Neighborhood Hits	219	Target Neighborhood Hits	517	Shared Neighborhood Hits	65
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.372629 (rank : 82)	θ value	8.97725e-08 (rank : 85)
Query Neighborhood Hits	219	Target Neighborhood Hits	589	Shared Neighborhood Hits	68
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RBNS5_HUMAN
NC score	0.357836 (rank : 83)	θ value	5.44631e-05 (rank : 104)
Query Neighborhood Hits	219	Target Neighborhood Hits	242	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ZFYV1_HUMAN
NC score	0.352226 (rank : 84)	θ value	0.000270298 (rank : 105)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

RBNS5_MOUSE
NC score	0.351028 (rank : 85)	θ value	4.1701e-05 (rank : 103)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFYV1_MOUSE
NC score	0.348820 (rank : 86)	θ value	0.00035302 (rank : 106)
Query Neighborhood Hits	219	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

SOS1_HUMAN
NC score	0.327510 (rank : 87)	θ value	6.21693e-09 (rank : 77)
Query Neighborhood Hits	219	Target Neighborhood Hits	274	Shared Neighborhood Hits	47
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
NC score	0.326115 (rank : 88)	θ value	4.76016e-09 (rank : 75)
Query Neighborhood Hits	219	Target Neighborhood Hits	193	Shared Neighborhood Hits	48
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ZFY19_HUMAN
NC score	0.316856 (rank : 89)	θ value	0.00665767 (rank : 113)
Query Neighborhood Hits	219	Target Neighborhood Hits	206	Shared Neighborhood Hits	47
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FYV1_HUMAN
NC score	0.314851 (rank : 90)	θ value	1.09739e-05 (rank : 99)
Query Neighborhood Hits	219	Target Neighborhood Hits	217	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.311621 (rank : 91)	θ value	1.09739e-05 (rank : 100)
Query Neighborhood Hits	219	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY19_MOUSE
NC score	0.309315 (rank : 92)	θ value	0.00869519 (rank : 115)
Query Neighborhood Hits	219	Target Neighborhood Hits	143	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

SOS1_MOUSE
NC score	0.308058 (rank : 93)	θ value	4.0297e-08 (rank : 82)
Query Neighborhood Hits	219	Target Neighborhood Hits	281	Shared Neighborhood Hits	45
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

WDFY1_HUMAN
NC score	0.285445 (rank : 94)	θ value	4.45536e-07 (rank : 91)
Query Neighborhood Hits	219	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

RUFY2_MOUSE
NC score	0.283950 (rank : 95)	θ value	8.11959e-09 (rank : 79)
Query Neighborhood Hits	219	Target Neighborhood Hits	820	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.281405 (rank : 96)	θ value	4.76016e-09 (rank : 73)
Query Neighborhood Hits	219	Target Neighborhood Hits	765	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.277905 (rank : 97)	θ value	6.21693e-09 (rank : 76)
Query Neighborhood Hits	219	Target Neighborhood Hits	848	Shared Neighborhood Hits	84
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY3_MOUSE
NC score	0.269293 (rank : 98)	θ value	1.99992e-07 (rank : 89)
Query Neighborhood Hits	219	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.269028 (rank : 99)	θ value	1.17247e-07 (rank : 86)
Query Neighborhood Hits	219	Target Neighborhood Hits	348	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY2_MOUSE
NC score	0.264805 (rank : 100)	θ value	6.43352e-06 (rank : 98)
Query Neighborhood Hits	219	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.262861 (rank : 101)	θ value	6.43352e-06 (rank : 97)
Query Neighborhood Hits	219	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

MTMR3_HUMAN
NC score	0.254779 (rank : 102)	θ value	2.88788e-06 (rank : 94)
Query Neighborhood Hits	219	Target Neighborhood Hits	163	Shared Neighborhood Hits	49
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY2_HUMAN
NC score	0.237010 (rank : 103)	θ value	4.76016e-09 (rank : 74)
Query Neighborhood Hits	219	Target Neighborhood Hits	1208	Shared Neighborhood Hits	84
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

DUET_HUMAN
NC score	0.224385 (rank : 104)	θ value	1.24977e-17 (rank : 28)
Query Neighborhood Hits	219	Target Neighborhood Hits	1220	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.218559 (rank : 105)	θ value	5.60996e-18 (rank : 27)
Query Neighborhood Hits	219	Target Neighborhood Hits	1580	Shared Neighborhood Hits	108
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

FYCO1_HUMAN
NC score	0.199901 (rank : 106)	θ value	1.63604e-09 (rank : 71)
Query Neighborhood Hits	219	Target Neighborhood Hits	1149	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

EEA1_MOUSE
NC score	0.192221 (rank : 107)	θ value	4.0297e-08 (rank : 81)
Query Neighborhood Hits	219	Target Neighborhood Hits	1637	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FYCO1_MOUSE
NC score	0.185221 (rank : 108)	θ value	4.92598e-06 (rank : 96)
Query Neighborhood Hits	219	Target Neighborhood Hits	1059	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_HUMAN
NC score	0.179626 (rank : 109)	θ value	8.11959e-09 (rank : 78)
Query Neighborhood Hits	219	Target Neighborhood Hits	1796	Shared Neighborhood Hits	98
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ZFY27_MOUSE
NC score	0.177739 (rank : 110)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	219	Target Neighborhood Hits	53	Shared Neighborhood Hits	40
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ANFY1_MOUSE
NC score	0.174748 (rank : 111)	θ value	4.1701e-05 (rank : 102)
Query Neighborhood Hits	219	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.174602 (rank : 112)	θ value	4.1701e-05 (rank : 101)
Query Neighborhood Hits	219	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ZFY27_HUMAN
NC score	0.171529 (rank : 113)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	219	Target Neighborhood Hits	64	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

PKHA6_HUMAN
NC score	0.160102 (rank : 114)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	219	Target Neighborhood Hits	556	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.157021 (rank : 115)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	219	Target Neighborhood Hits	591	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

NCF1_HUMAN
NC score	0.123152 (rank : 116)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3K1_HUMAN
NC score	0.122845 (rank : 117)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	219	Target Neighborhood Hits	341	Shared Neighborhood Hits	34
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ALS2_MOUSE
NC score	0.119702 (rank : 118)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	219	Target Neighborhood Hits	111	Shared Neighborhood Hits	25
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CD2AP_HUMAN
NC score	0.115740 (rank : 119)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	219	Target Neighborhood Hits	315	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.114295 (rank : 120)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	219	Target Neighborhood Hits	332	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF1_MOUSE
NC score	0.114203 (rank : 121)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	219	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_MOUSE
NC score	0.113753 (rank : 122)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	219	Target Neighborhood Hits	336	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PKHA5_HUMAN
NC score	0.110192 (rank : 123)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	219	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

SWP70_HUMAN
NC score	0.109993 (rank : 124)	θ value	0.0330416 (rank : 118)
Query Neighborhood Hits	219	Target Neighborhood Hits	973	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.106134 (rank : 125)	θ value	0.0563607 (rank : 121)
Query Neighborhood Hits	219	Target Neighborhood Hits	1097	Shared Neighborhood Hits	93
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SRBS1_MOUSE
NC score	0.105280 (rank : 126)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	219	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.104654 (rank : 127)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	219	Target Neighborhood Hits	396	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ALS2_HUMAN
NC score	0.104029 (rank : 128)	θ value	1.38821 (rank : 148)
Query Neighborhood Hits	219	Target Neighborhood Hits	121	Shared Neighborhood Hits	25
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

OBSCN_HUMAN
NC score	0.103507 (rank : 129)	θ value	7.34386e-10 (rank : 70)
Query Neighborhood Hits	219	Target Neighborhood Hits	1931	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

NCF2_HUMAN
NC score	0.103371 (rank : 130)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	219	Target Neighborhood Hits	229	Shared Neighborhood Hits	28
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK1_HUMAN
NC score	0.100552 (rank : 131)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PKHA4_MOUSE
NC score	0.100271 (rank : 132)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	219	Target Neighborhood Hits	202	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

VINEX_HUMAN
NC score	0.099758 (rank : 133)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	219	Target Neighborhood Hits	270	Shared Neighborhood Hits	29
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.099153 (rank : 134)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	219	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

PKHA4_HUMAN
NC score	0.099082 (rank : 135)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	219	Target Neighborhood Hits	283	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

NCK2_HUMAN
NC score	0.097023 (rank : 136)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

CYH3_MOUSE
NC score	0.095187 (rank : 137)	θ value	0.0193708 (rank : 116)
Query Neighborhood Hits	219	Target Neighborhood Hits	148	Shared Neighborhood Hits	46
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

GRAP_HUMAN
NC score	0.095153 (rank : 138)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.094334 (rank : 139)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	219	Target Neighborhood Hits	309	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

DGKH_HUMAN
NC score	0.093342 (rank : 140)	θ value	0.000786445 (rank : 107)
Query Neighborhood Hits	219	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

STAM1_HUMAN
NC score	0.092573 (rank : 141)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	219	Target Neighborhood Hits	271	Shared Neighborhood Hits	27
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.091731 (rank : 142)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	219	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_MOUSE
NC score	0.091482 (rank : 143)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	219	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_HUMAN
NC score	0.091436 (rank : 144)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	219	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_HUMAN
NC score	0.091174 (rank : 145)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	219	Target Neighborhood Hits	161	Shared Neighborhood Hits	21
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM2_HUMAN
NC score	0.089752 (rank : 146)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	219	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
NC score	0.089666 (rank : 147)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	219	Target Neighborhood Hits	285	Shared Neighborhood Hits	30
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAC_MOUSE
NC score	0.088516 (rank : 148)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	219	Target Neighborhood Hits	268	Shared Neighborhood Hits	27
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

RUFY3_MOUSE
NC score	0.086498 (rank : 149)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	219	Target Neighborhood Hits	579	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.085998 (rank : 150)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	219	Target Neighborhood Hits	594	Shared Neighborhood Hits	39
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

CYH4_MOUSE
NC score	0.085099 (rank : 151)	θ value	0.279714 (rank : 129)
Query Neighborhood Hits	219	Target Neighborhood Hits	134	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

GRB2_HUMAN
NC score	0.084620 (rank : 152)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	219	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.084583 (rank : 153)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	219	Target Neighborhood Hits	312	Shared Neighborhood Hits	25
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PKHA2_MOUSE
NC score	0.082753 (rank : 154)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	219	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

MELPH_MOUSE
NC score	0.082592 (rank : 155)	θ value	0.365318 (rank : 134)
Query Neighborhood Hits	219	Target Neighborhood Hits	112	Shared Neighborhood Hits	18
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

BI2L1_HUMAN
NC score	0.080819 (rank : 156)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	219	Target Neighborhood Hits	156	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CNKR1_HUMAN
NC score	0.080483 (rank : 157)	θ value	5.27518 (rank : 181)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	30
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

ABI2_HUMAN
NC score	0.080106 (rank : 158)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	219	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.079865 (rank : 159)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	219	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PPIP1_HUMAN
NC score	0.079817 (rank : 160)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	219	Target Neighborhood Hits	389	Shared Neighborhood Hits	45
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

MYRIP_MOUSE
NC score	0.079618 (rank : 161)	θ value	0.125558 (rank : 124)
Query Neighborhood Hits	219	Target Neighborhood Hits	207	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

STAC3_MOUSE
NC score	0.079010 (rank : 162)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	219	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CYH4_HUMAN
NC score	0.078814 (rank : 163)	θ value	0.47712 (rank : 135)
Query Neighborhood Hits	219	Target Neighborhood Hits	135	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

GRAP2_HUMAN
NC score	0.078540 (rank : 164)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	219	Target Neighborhood Hits	304	Shared Neighborhood Hits	25
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

STAC3_HUMAN
NC score	0.078129 (rank : 165)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	219	Target Neighborhood Hits	228	Shared Neighborhood Hits	25
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRAP2_MOUSE
NC score	0.078124 (rank : 166)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	219	Target Neighborhood Hits	297	Shared Neighborhood Hits	24
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PPIP1_MOUSE
NC score	0.078068 (rank : 167)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	219	Target Neighborhood Hits	377	Shared Neighborhood Hits	44
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CYH1_HUMAN
NC score	0.077990 (rank : 168)	θ value	0.62314 (rank : 141)
Query Neighborhood Hits	219	Target Neighborhood Hits	184	Shared Neighborhood Hits	52
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

HCLS1_HUMAN
NC score	0.077883 (rank : 169)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	219	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SRC8_HUMAN
NC score	0.077774 (rank : 170)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	219	Target Neighborhood Hits	269	Shared Neighborhood Hits	27
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

HCLS1_MOUSE
NC score	0.077685 (rank : 171)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	219	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

OSBL9_HUMAN
NC score	0.077293 (rank : 172)	θ value	0.0431538 (rank : 119)
Query Neighborhood Hits	219	Target Neighborhood Hits	138	Shared Neighborhood Hits	37
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

ABI1_MOUSE
NC score	0.076983 (rank : 173)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	219	Target Neighborhood Hits	246	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CYH3_HUMAN
NC score	0.076868 (rank : 174)	θ value	0.365318 (rank : 133)
Query Neighborhood Hits	219	Target Neighborhood Hits	137	Shared Neighborhood Hits	41
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

SRC8_MOUSE
NC score	0.076490 (rank : 175)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	219	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

DGKD_HUMAN
NC score	0.076204 (rank : 176)	θ value	0.0252991 (rank : 117)
Query Neighborhood Hits	219	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PKHA2_HUMAN
NC score	0.076167 (rank : 177)	θ value	1.81305 (rank : 162)
Query Neighborhood Hits	219	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

SH3G3_MOUSE
NC score	0.076087 (rank : 178)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	219	Target Neighborhood Hits	236	Shared Neighborhood Hits	25
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PLCG1_MOUSE
NC score	0.075172 (rank : 179)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	219	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CYH1_MOUSE
NC score	0.075119 (rank : 180)	θ value	1.38821 (rank : 151)
Query Neighborhood Hits	219	Target Neighborhood Hits	176	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

SH3G1_HUMAN
NC score	0.074686 (rank : 181)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
NC score	0.074102 (rank : 182)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	219	Target Neighborhood Hits	324	Shared Neighborhood Hits	35
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CYH2_HUMAN
NC score	0.073835 (rank : 183)	θ value	1.06291 (rank : 145)
Query Neighborhood Hits	219	Target Neighborhood Hits	175	Shared Neighborhood Hits	46
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.073825 (rank : 184)	θ value	1.06291 (rank : 146)
Query Neighborhood Hits	219	Target Neighborhood Hits	171	Shared Neighborhood Hits	46
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PLCG1_HUMAN
NC score	0.073694 (rank : 185)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	219	Target Neighborhood Hits	293	Shared Neighborhood Hits	25
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

3BP2_HUMAN
NC score	0.073586 (rank : 186)	θ value	1.38821 (rank : 147)
Query Neighborhood Hits	219	Target Neighborhood Hits	296	Shared Neighborhood Hits	30
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SH3G3_HUMAN
NC score	0.073397 (rank : 187)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	219	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRKL_HUMAN
NC score	0.073197 (rank : 188)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	219	Target Neighborhood Hits	313	Shared Neighborhood Hits	22
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

AHI1_HUMAN
NC score	0.073152 (rank : 189)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	219	Target Neighborhood Hits	537	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

MELPH_HUMAN
NC score	0.072728 (rank : 190)	θ value	0.62314 (rank : 143)
Query Neighborhood Hits	219	Target Neighborhood Hits	145	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

SHAN2_MOUSE
NC score	0.072523 (rank : 191)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	219	Target Neighborhood Hits	446	Shared Neighborhood Hits	32
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA2_HUMAN
NC score	0.072223 (rank : 192)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	219	Target Neighborhood Hits	888	Shared Neighborhood Hits	65
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ABI1_HUMAN
NC score	0.072074 (rank : 193)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	219	Target Neighborhood Hits	257	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G2_MOUSE
NC score	0.071835 (rank : 194)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	219	Target Neighborhood Hits	319	Shared Neighborhood Hits	35
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

GRP3_HUMAN
NC score	0.071445 (rank : 195)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	219	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

CRKL_MOUSE
NC score	0.071331 (rank : 196)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

NEBL_HUMAN
NC score	0.070679 (rank : 197)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	219	Target Neighborhood Hits	457	Shared Neighborhood Hits	49
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SH3G1_MOUSE
NC score	0.070334 (rank : 198)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	219	Target Neighborhood Hits	291	Shared Neighborhood Hits	28
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CRK_MOUSE
NC score	0.069603 (rank : 199)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	219	Target Neighborhood Hits	314	Shared Neighborhood Hits	26
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI3_HUMAN
NC score	0.069190 (rank : 200)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	219	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

TCGAP_MOUSE
NC score	0.068783 (rank : 201)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	219	Target Neighborhood Hits	409	Shared Neighborhood Hits	38
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

3BP2_MOUSE
NC score	0.068505 (rank : 202)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	219	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

OSTF1_HUMAN
NC score	0.068035 (rank : 203)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	219	Target Neighborhood Hits	466	Shared Neighborhood Hits	28
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DDEF2_MOUSE
NC score	0.067935 (rank : 204)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	219	Target Neighborhood Hits	625	Shared Neighborhood Hits	52
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.067672 (rank : 205)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	219	Target Neighborhood Hits	599	Shared Neighborhood Hits	52
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

OSTF1_MOUSE
NC score	0.067668 (rank : 206)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	219	Target Neighborhood Hits	467	Shared Neighborhood Hits	30
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ABI3_MOUSE
NC score	0.067154 (rank : 207)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	219	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_MOUSE
NC score	0.066750 (rank : 208)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	219	Target Neighborhood Hits	496	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CRK_HUMAN
NC score	0.066459 (rank : 209)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	219	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

TCGAP_HUMAN
NC score	0.066399 (rank : 210)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	219	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BI2L1_MOUSE
NC score	0.066396 (rank : 211)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SPTA1_HUMAN
NC score	0.065256 (rank : 212)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	219	Target Neighborhood Hits	748	Shared Neighborhood Hits	64
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MYRIP_HUMAN
NC score	0.064887 (rank : 213)	θ value	0.47712 (rank : 139)
Query Neighborhood Hits	219	Target Neighborhood Hits	269	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

DBNL_HUMAN
NC score	0.064607 (rank : 214)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	219	Target Neighborhood Hits	244	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SPTA1_MOUSE
NC score	0.064091 (rank : 215)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	219	Target Neighborhood Hits	675	Shared Neighborhood Hits	55
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RHG04_HUMAN
NC score	0.062992 (rank : 216)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	219	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PLCG2_HUMAN
NC score	0.062884 (rank : 217)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	219	Target Neighborhood Hits	280	Shared Neighborhood Hits	22
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

CNKR2_MOUSE
NC score	0.062774 (rank : 218)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

NOXO1_MOUSE
NC score	0.062625 (rank : 219)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	219	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

CENB2_HUMAN
NC score	0.062558 (rank : 220)	θ value	0.00869519 (rank : 114)
Query Neighborhood Hits	219	Target Neighborhood Hits	425	Shared Neighborhood Hits	52
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CNKR2_HUMAN
NC score	0.062441 (rank : 221)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	219	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

NPHP1_MOUSE
NC score	0.061850 (rank : 222)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	219	Target Neighborhood Hits	267	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

E41LB_HUMAN
NC score	0.061657 (rank : 223)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	219	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

DBNL_MOUSE
NC score	0.061573 (rank : 224)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	219	Target Neighborhood Hits	306	Shared Neighborhood Hits	25
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

E41L3_HUMAN
NC score	0.060927 (rank : 225)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	219	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

PLEK_HUMAN
NC score	0.060749 (rank : 226)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	219	Target Neighborhood Hits	110	Shared Neighborhood Hits	32
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

IQEC3_HUMAN
NC score	0.060622 (rank : 227)	θ value	0.0563607 (rank : 120)
Query Neighborhood Hits	219	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

E41L5_HUMAN
NC score	0.060612 (rank : 228)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	219	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

DGKK_HUMAN
NC score	0.060611 (rank : 229)	θ value	0.279714 (rank : 130)
Query Neighborhood Hits	219	Target Neighborhood Hits	378	Shared Neighborhood Hits	31
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

E41LB_MOUSE
NC score	0.060590 (rank : 230)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	219	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

CENB5_HUMAN
NC score	0.060503 (rank : 231)	θ value	0.62314 (rank : 140)
Query Neighborhood Hits	219	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

LASP1_HUMAN
NC score	0.060484 (rank : 232)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	219	Target Neighborhood Hits	293	Shared Neighborhood Hits	24
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

RPGF1_HUMAN
NC score	0.060409 (rank : 233)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	219	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SHAN1_HUMAN
NC score	0.060192 (rank : 234)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	219	Target Neighborhood Hits	1041	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

41_HUMAN
NC score	0.059688 (rank : 235)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	219	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L2_MOUSE
NC score	0.059568 (rank : 236)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	219	Target Neighborhood Hits	459	Shared Neighborhood Hits	21
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

FRMD5_MOUSE
NC score	0.059206 (rank : 237)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	219	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

LASP1_MOUSE
NC score	0.058918 (rank : 238)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	219	Target Neighborhood Hits	297	Shared Neighborhood Hits	24
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

E41L3_MOUSE
NC score	0.058890 (rank : 239)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	219	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

FRMD5_HUMAN
NC score	0.058808 (rank : 240)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	219	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L1_HUMAN
NC score	0.058568 (rank : 241)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	219	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

PACN2_MOUSE
NC score	0.058380 (rank : 242)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	219	Target Neighborhood Hits	382	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

FNBP2_HUMAN
NC score	0.058347 (rank : 243)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	219	Target Neighborhood Hits	432	Shared Neighborhood Hits	44
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ASPP1_MOUSE
NC score	0.058197 (rank : 244)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	219	Target Neighborhood Hits	1244	Shared Neighborhood Hits	70
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

41_MOUSE
NC score	0.058005 (rank : 245)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	219	Target Neighborhood Hits	184	Shared Neighborhood Hits	5
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L1_MOUSE
NC score	0.057941 (rank : 246)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	219	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
NC score	0.057937 (rank : 247)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	219	Target Neighborhood Hits	287	Shared Neighborhood Hits	13
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

PACN2_HUMAN
NC score	0.057846 (rank : 248)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	219	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

EFS_MOUSE
NC score	0.057810 (rank : 249)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	219	Target Neighborhood Hits	389	Shared Neighborhood Hits	24
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MOES_MOUSE
NC score	0.057790 (rank : 250)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	219	Target Neighborhood Hits	923	Shared Neighborhood Hits	46
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

PLEK_MOUSE
NC score	0.057647 (rank : 251)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	219	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

DDEF1_MOUSE
NC score	0.057584 (rank : 252)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	219	Target Neighborhood Hits	592	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MOES_HUMAN
NC score	0.057472 (rank : 253)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	219	Target Neighborhood Hits	892	Shared Neighborhood Hits	48
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

ANM2_HUMAN
NC score	0.057321 (rank : 254)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	219	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RHG26_HUMAN
NC score	0.056993 (rank : 255)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	219	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRGP1_HUMAN
NC score	0.056836 (rank : 256)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	219	Target Neighborhood Hits	390	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

RIMB1_HUMAN
NC score	0.056811 (rank : 257)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	219	Target Neighborhood Hits	1479	Shared Neighborhood Hits	71
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PEX13_MOUSE
NC score	0.056431 (rank : 258)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	219	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

BCAR1_MOUSE
NC score	0.056346 (rank : 259)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	219	Target Neighborhood Hits	438	Shared Neighborhood Hits	29
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EP15R_MOUSE
NC score	0.056114 (rank : 260)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	219	Target Neighborhood Hits	1135	Shared Neighborhood Hits	51
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15R_HUMAN
NC score	0.055996 (rank : 261)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	219	Target Neighborhood Hits	1083	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

RADI_HUMAN
NC score	0.055942 (rank : 262)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	219	Target Neighborhood Hits	741	Shared Neighborhood Hits	40
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

K1914_HUMAN
NC score	0.055816 (rank : 263)	θ value	0.47712 (rank : 137)
Query Neighborhood Hits	219	Target Neighborhood Hits	255	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

PACN3_HUMAN
NC score	0.055640 (rank : 264)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	219	Target Neighborhood Hits	385	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

GOGA3_MOUSE
NC score	0.055571 (rank : 265)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	219	Target Neighborhood Hits	1437	Shared Neighborhood Hits	60
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

NOXO1_HUMAN
NC score	0.055270 (rank : 266)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	219	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BCAR1_HUMAN
NC score	0.055180 (rank : 267)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	219	Target Neighborhood Hits	554	Shared Neighborhood Hits	29
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PACN3_MOUSE
NC score	0.055163 (rank : 268)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	219	Target Neighborhood Hits	380	Shared Neighborhood Hits	39
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

MERL_MOUSE
NC score	0.055047 (rank : 269)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	219	Target Neighborhood Hits	524	Shared Neighborhood Hits	37
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

PEX13_HUMAN
NC score	0.054987 (rank : 270)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	219	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

E41LA_HUMAN
NC score	0.054986 (rank : 271)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	219	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

RADI_MOUSE
NC score	0.054979 (rank : 272)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	219	Target Neighborhood Hits	773	Shared Neighborhood Hits	42
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

MERL_HUMAN
NC score	0.054823 (rank : 273)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	219	Target Neighborhood Hits	532	Shared Neighborhood Hits	37
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

RFFL_MOUSE
NC score	0.054640 (rank : 274)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	219	Target Neighborhood Hits	145	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

LMO7_HUMAN
NC score	0.054401 (rank : 275)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	219	Target Neighborhood Hits	507	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

EP15_HUMAN
NC score	0.054377 (rank : 276)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	219	Target Neighborhood Hits	1021	Shared Neighborhood Hits	50
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

E41LA_MOUSE
NC score	0.054330 (rank : 277)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	219	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

RNF34_MOUSE
NC score	0.054124 (rank : 278)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	219	Target Neighborhood Hits	160	Shared Neighborhood Hits	30
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

EZRI_HUMAN
NC score	0.053835 (rank : 279)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	219	Target Neighborhood Hits	663	Shared Neighborhood Hits	40
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
NC score	0.053742 (rank : 280)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	219	Target Neighborhood Hits	693	Shared Neighborhood Hits	40
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

NHLC1_MOUSE
NC score	0.053463 (rank : 281)	θ value	1.81305 (rank : 160)
Query Neighborhood Hits	219	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

ANM2_MOUSE
NC score	0.053453 (rank : 282)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	219	Target Neighborhood Hits	175	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP2_MOUSE
NC score	0.053360 (rank : 283)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	219	Target Neighborhood Hits	324	Shared Neighborhood Hits	38
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CT032_HUMAN
NC score	0.053226 (rank : 284)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	219	Target Neighborhood Hits	235	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

RFIP3_HUMAN
NC score	0.052985 (rank : 285)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	219	Target Neighborhood Hits	1055	Shared Neighborhood Hits	57
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

IQEC3_MOUSE
NC score	0.052798 (rank : 286)	θ value	0.279714 (rank : 131)
Query Neighborhood Hits	219	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

RIMB1_MOUSE
NC score	0.052759 (rank : 287)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	219	Target Neighborhood Hits	1376	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRGP2_HUMAN
NC score	0.052651 (rank : 288)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	219	Target Neighborhood Hits	331	Shared Neighborhood Hits	37
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

NPHP1_HUMAN
NC score	0.052013 (rank : 289)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	219	Target Neighborhood Hits	288	Shared Neighborhood Hits	31
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RGL1_HUMAN
NC score	0.051666 (rank : 290)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	219	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

MD1L1_MOUSE
NC score	0.051660 (rank : 291)	θ value	0.62314 (rank : 142)
Query Neighborhood Hits	219	Target Neighborhood Hits	1001	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

NEBU_HUMAN
NC score	0.051506 (rank : 292)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	219	Target Neighborhood Hits	420	Shared Neighborhood Hits	36
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

EP15_MOUSE
NC score	0.051424 (rank : 293)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	219	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

PACN1_MOUSE
NC score	0.051411 (rank : 294)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	219	Target Neighborhood Hits	283	Shared Neighborhood Hits	31
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PKHA1_HUMAN
NC score	0.051239 (rank : 295)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	219	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

REPS1_MOUSE
NC score	0.051139 (rank : 296)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	219	Target Neighborhood Hits	204	Shared Neighborhood Hits	17
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

PACN1_HUMAN
NC score	0.050994 (rank : 297)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	219	Target Neighborhood Hits	320	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

MYLIP_MOUSE
NC score	0.050863 (rank : 298)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	219	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CEND1_HUMAN
NC score	0.050841 (rank : 299)	θ value	6.88961 (rank : 194)
Query Neighborhood Hits	219	Target Neighborhood Hits	284	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

MYLIP_HUMAN
NC score	0.050685 (rank : 300)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	219	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CEP63_HUMAN
NC score	0.050420 (rank : 301)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	219	Target Neighborhood Hits	1005	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CARD9_HUMAN
NC score	0.050340 (rank : 302)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	219	Target Neighborhood Hits	602	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

RNF34_HUMAN
NC score	0.050268 (rank : 303)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	219	Target Neighborhood Hits	153	Shared Neighborhood Hits	27
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

P85A_HUMAN
NC score	0.050266 (rank : 304)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	219	Target Neighborhood Hits	479	Shared Neighborhood Hits	45
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ASPP1_HUMAN
NC score	0.050251 (rank : 305)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	219	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAIP2_MOUSE
NC score	0.050114 (rank : 306)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	219	Target Neighborhood Hits	185	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

KMHN1_MOUSE
NC score	0.050090 (rank : 307)	θ value	5.27518 (rank : 183)
Query Neighborhood Hits	219	Target Neighborhood Hits	949	Shared Neighborhood Hits	52
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

CEND1_MOUSE
NC score	0.049601 (rank : 308)	θ value	1.38821 (rank : 149)
Query Neighborhood Hits	219	Target Neighborhood Hits	260	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

KMHN1_HUMAN
NC score	0.049385 (rank : 309)	θ value	1.81305 (rank : 159)
Query Neighborhood Hits	219	Target Neighborhood Hits	950	Shared Neighborhood Hits	49
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

DESP_HUMAN
NC score	0.049027 (rank : 310)	θ value	0.813845 (rank : 144)
Query Neighborhood Hits	219	Target Neighborhood Hits	1470	Shared Neighborhood Hits	56
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

GOGA4_HUMAN
NC score	0.048807 (rank : 311)	θ value	8.99809 (rank : 210)
Query Neighborhood Hits	219	Target Neighborhood Hits	2034	Shared Neighborhood Hits	73
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

CENB1_HUMAN
NC score	0.048762 (rank : 312)	θ value	0.365318 (rank : 132)
Query Neighborhood Hits	219	Target Neighborhood Hits	383	Shared Neighborhood Hits	41
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

FLIP1_HUMAN
NC score	0.048460 (rank : 313)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	219	Target Neighborhood Hits	1405	Shared Neighborhood Hits	57
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

DP13B_HUMAN
NC score	0.048296 (rank : 314)	θ value	0.21417 (rank : 127)
Query Neighborhood Hits	219	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

GOGB1_HUMAN
NC score	0.045871 (rank : 315)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	219	Target Neighborhood Hits	2297	Shared Neighborhood Hits	76
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ZCH13_HUMAN
NC score	0.045079 (rank : 316)	θ value	0.0961366 (rank : 123)
Query Neighborhood Hits	219	Target Neighborhood Hits	151	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WW36	Gene names	ZCCHC13
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 13.

GOGA4_MOUSE
NC score	0.044291 (rank : 317)	θ value	1.81305 (rank : 158)
Query Neighborhood Hits	219	Target Neighborhood Hits	1939	Shared Neighborhood Hits	67
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SYTL4_HUMAN
NC score	0.044262 (rank : 318)	θ value	2.36792 (rank : 170)
Query Neighborhood Hits	219	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

FLIP1_MOUSE
NC score	0.043723 (rank : 319)	θ value	8.99809 (rank : 209)
Query Neighborhood Hits	219	Target Neighborhood Hits	1176	Shared Neighborhood Hits	54
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

TXLNA_MOUSE
NC score	0.043613 (rank : 320)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	219	Target Neighborhood Hits	846	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

NHLC1_HUMAN
NC score	0.043181 (rank : 321)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	219	Target Neighborhood Hits	91	Shared Neighborhood Hits	7
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

DP13B_MOUSE
NC score	0.043076 (rank : 322)	θ value	1.38821 (rank : 152)
Query Neighborhood Hits	219	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

SYCP1_MOUSE
NC score	0.042296 (rank : 323)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	219	Target Neighborhood Hits	1456	Shared Neighborhood Hits	62
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CYTSA_HUMAN
NC score	0.041534 (rank : 324)	θ value	6.88961 (rank : 196)
Query Neighborhood Hits	219	Target Neighborhood Hits	1138	Shared Neighborhood Hits	50
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CENA1_HUMAN
NC score	0.041150 (rank : 325)	θ value	1.81305 (rank : 157)
Query Neighborhood Hits	219	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

TXLNA_HUMAN
NC score	0.040516 (rank : 326)	θ value	1.38821 (rank : 155)
Query Neighborhood Hits	219	Target Neighborhood Hits	982	Shared Neighborhood Hits	42
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

MYH9_HUMAN
NC score	0.040134 (rank : 327)	θ value	0.00134147 (rank : 110)
Query Neighborhood Hits	219	Target Neighborhood Hits	1762	Shared Neighborhood Hits	66
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

BPA1_MOUSE
NC score	0.039282 (rank : 328)	θ value	2.36792 (rank : 166)
Query Neighborhood Hits	219	Target Neighborhood Hits	1477	Shared Neighborhood Hits	54
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

K1914_MOUSE
NC score	0.038883 (rank : 329)	θ value	1.38821 (rank : 153)
Query Neighborhood Hits	219	Target Neighborhood Hits	216	Shared Neighborhood Hits	21
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MYH9_MOUSE
NC score	0.038794 (rank : 330)	θ value	0.00102713 (rank : 108)
Query Neighborhood Hits	219	Target Neighborhood Hits	1829	Shared Neighborhood Hits	66
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RGS3_MOUSE
NC score	0.038395 (rank : 331)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	219	Target Neighborhood Hits	1621	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CEND2_HUMAN
NC score	0.036948 (rank : 332)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

MYH10_HUMAN
NC score	0.035537 (rank : 333)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	219	Target Neighborhood Hits	1620	Shared Neighborhood Hits	60
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH8_HUMAN
NC score	0.035520 (rank : 334)	θ value	2.36792 (rank : 168)
Query Neighborhood Hits	219	Target Neighborhood Hits	1610	Shared Neighborhood Hits	64
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

TACC2_HUMAN
NC score	0.035508 (rank : 335)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	219	Target Neighborhood Hits	856	Shared Neighborhood Hits	46
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

MYH10_MOUSE
NC score	0.035414 (rank : 336)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	219	Target Neighborhood Hits	1612	Shared Neighborhood Hits	60
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH1_HUMAN
NC score	0.035369 (rank : 337)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	219	Target Neighborhood Hits	1478	Shared Neighborhood Hits	59
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH2_HUMAN
NC score	0.034387 (rank : 338)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	219	Target Neighborhood Hits	1491	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

CCD94_MOUSE
NC score	0.034281 (rank : 339)	θ value	5.27518 (rank : 180)
Query Neighborhood Hits	219	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D6J3	Gene names	Ccdc94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

SNX23_HUMAN
NC score	0.034242 (rank : 340)	θ value	0.00665767 (rank : 112)
Query Neighborhood Hits	219	Target Neighborhood Hits	944	Shared Neighborhood Hits	46
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

RASA2_MOUSE
NC score	0.032680 (rank : 341)	θ value	1.81305 (rank : 163)
Query Neighborhood Hits	219	Target Neighborhood Hits	159	Shared Neighborhood Hits	29
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

SYTL4_MOUSE
NC score	0.031807 (rank : 342)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	219	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

MYH4_HUMAN
NC score	0.031017 (rank : 343)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	219	Target Neighborhood Hits	1377	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

RASA3_MOUSE
NC score	0.030158 (rank : 344)	θ value	1.81305 (rank : 164)
Query Neighborhood Hits	219	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA3_HUMAN
NC score	0.029050 (rank : 345)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	219	Target Neighborhood Hits	166	Shared Neighborhood Hits	37
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

CTRO_MOUSE
NC score	0.028312 (rank : 346)	θ value	0.0961366 (rank : 122)
Query Neighborhood Hits	219	Target Neighborhood Hits	2344	Shared Neighborhood Hits	67
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DDFL1_HUMAN
NC score	0.027540 (rank : 347)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	219	Target Neighborhood Hits	353	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CCD94_HUMAN
NC score	0.027094 (rank : 348)	θ value	4.03905 (rank : 176)
Query Neighborhood Hits	219	Target Neighborhood Hits	139	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BW85, O75270, Q9H862, Q9NW16	Gene names	CCDC94
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 94.

CN094_HUMAN
NC score	0.025951 (rank : 349)	θ value	1.38821 (rank : 150)
Query Neighborhood Hits	219	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H6D7, Q86T15, Q86T16, Q86U43, Q9NX59	Gene names	C14orf94
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf94.

RGS3_HUMAN
NC score	0.025245 (rank : 350)	θ value	5.27518 (rank : 190)
Query Neighborhood Hits	219	Target Neighborhood Hits	1375	Shared Neighborhood Hits	40
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CTRO_HUMAN
NC score	0.023359 (rank : 351)	θ value	4.03905 (rank : 177)
Query Neighborhood Hits	219	Target Neighborhood Hits	2092	Shared Neighborhood Hits	63
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

NC6IP_MOUSE
NC score	0.021979 (rank : 352)	θ value	0.163984 (rank : 125)
Query Neighborhood Hits	219	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

SYTL5_MOUSE
NC score	0.021596 (rank : 353)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	219	Target Neighborhood Hits	154	Shared Neighborhood Hits	19
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

3BP1_MOUSE
NC score	0.020226 (rank : 354)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	219	Target Neighborhood Hits	238	Shared Neighborhood Hits	13
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

PARN_MOUSE
NC score	0.019195 (rank : 355)	θ value	1.81305 (rank : 161)
Query Neighborhood Hits	219	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDG3, Q8C7N6, Q9DC46	Gene names	Parn
Domain Architecture	No domain graphic available
Description	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate- specific ribonuclease).

PARN_HUMAN
NC score	0.018263 (rank : 356)	θ value	2.36792 (rank : 169)
Query Neighborhood Hits	219	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O95453	Gene names	PARN, DAN
Domain Architecture	No domain graphic available
Description	Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate- specific ribonuclease) (Deadenylating nuclease) (Deadenylation nuclease).

EXOC8_MOUSE
NC score	0.018044 (rank : 357)	θ value	8.99809 (rank : 208)
Query Neighborhood Hits	219	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q6PGF7	Gene names	Exoc8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

CENG2_MOUSE
NC score	0.015968 (rank : 358)	θ value	6.88961 (rank : 195)
Query Neighborhood Hits	219	Target Neighborhood Hits	463	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

MCM4_HUMAN
NC score	0.014420 (rank : 359)	θ value	0.47712 (rank : 138)
Query Neighborhood Hits	219	Target Neighborhood Hits	59	Shared Neighborhood Hits	6
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

OSBL8_HUMAN
NC score	0.013151 (rank : 360)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	219	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

EXOC3_HUMAN
NC score	0.012693 (rank : 361)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	219	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	O60645, Q8TEN6, Q8WUW0, Q96DI4	Gene names	EXOC3, SEC6, SEC6L1
Domain Architecture
Description	Exocyst complex component 3 (Exocyst complex component Sec6).

SRP68_HUMAN
NC score	0.010295 (rank : 362)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	219	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UHB9, Q8NCJ4, Q8WUK2	Gene names	SRP68
Domain Architecture	No domain graphic available
Description	Signal recognition particle 68 kDa protein (SRP68).

NOLC1_HUMAN
NC score	0.010288 (rank : 363)	θ value	1.38821 (rank : 154)
Query Neighborhood Hits	219	Target Neighborhood Hits	452	Shared Neighborhood Hits	9
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NP1L3_MOUSE
NC score	0.009075 (rank : 364)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	219	Target Neighborhood Hits	233	Shared Neighborhood Hits	12
SwissProt Accessions	Q794H2, O54802	Gene names	Nap1l3, Mb20
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20).

HS90A_MOUSE
NC score	0.008450 (rank : 365)	θ value	2.36792 (rank : 167)
Query Neighborhood Hits	219	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	P07901	Gene names	Hsp90aa1, Hsp86, Hsp86-1, Hspca
Domain Architecture
Description	Heat shock protein HSP 90-alpha (HSP 86) (Tumor-specific transplantation 86 kDa antigen) (TSTA).

BMX_HUMAN
NC score	0.008264 (rank : 366)	θ value	0.21417 (rank : 126)
Query Neighborhood Hits	219	Target Neighborhood Hits	942	Shared Neighborhood Hits	32
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CYLD_HUMAN
NC score	0.008065 (rank : 367)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	219	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

CYLD_MOUSE
NC score	0.007275 (rank : 368)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	219	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

BMX_MOUSE
NC score	0.006412 (rank : 369)	θ value	1.81305 (rank : 156)
Query Neighborhood Hits	219	Target Neighborhood Hits	912	Shared Neighborhood Hits	28
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

EZH2_HUMAN
NC score	0.005645 (rank : 370)	θ value	5.27518 (rank : 182)
Query Neighborhood Hits	219	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_MOUSE
NC score	0.005237 (rank : 371)	θ value	6.88961 (rank : 198)
Query Neighborhood Hits	219	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

PPAL_HUMAN
NC score	0.004439 (rank : 372)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	219	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P11117, Q9BTU7	Gene names	ACP2
Domain Architecture
Description	Lysosomal acid phosphatase precursor (EC 3.1.3.2) (LAP).

MEFV_HUMAN
NC score	0.001269 (rank : 373)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	219	Target Neighborhood Hits	431	Shared Neighborhood Hits	18
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

SOX12_MOUSE
NC score	0.000781 (rank : 374)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q04890, P70417, Q6NXL2	Gene names	Sox12, Sox-12
Domain Architecture	No domain graphic available
Description	SOX-12 protein.

KCNH1_HUMAN
NC score	0.000368 (rank : 375)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	219	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

PKN2_HUMAN
NC score	0.000260 (rank : 376)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	219	Target Neighborhood Hits	892	Shared Neighborhood Hits	13
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

EVI1_HUMAN
NC score	-0.002007 (rank : 377)	θ value	0.21417 (rank : 128)
Query Neighborhood Hits	219	Target Neighborhood Hits	924	Shared Neighborhood Hits	14
SwissProt Accessions	Q03112, Q16122, Q99917	Gene names	EVI1
Domain Architecture
Description	Ecotropic virus integration 1 site protein.

PCDG5_HUMAN
NC score	-0.002557 (rank : 378)	θ value	5.27518 (rank : 188)
Query Neighborhood Hits	219	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5G8, Q9Y5D2	Gene names	PCDHGA5
Domain Architecture
Description	Protocadherin gamma A5 precursor (PCDH-gamma-A5).

EVI1_MOUSE
NC score	-0.004412 (rank : 379)	θ value	8.99809 (rank : 207)
Query Neighborhood Hits	219	Target Neighborhood Hits	826	Shared Neighborhood Hits	12
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

PRD16_HUMAN
NC score	-0.005019 (rank : 380)	θ value	5.27518 (rank : 189)
Query Neighborhood Hits	219	Target Neighborhood Hits	832	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HAZ2, Q8WYJ9, Q9C0I8	Gene names	PRDM16, KIAA1675, MEL1, PFM13
Domain Architecture
Description	PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1).

HKR1_HUMAN
NC score	-0.005591 (rank : 381)	θ value	0.47712 (rank : 136)
Query Neighborhood Hits	219	Target Neighborhood Hits	759	Shared Neighborhood Hits	7
SwissProt Accessions	P10072, Q9BSW9, Q9UM09	Gene names	HKR1
Domain Architecture
Description	Krueppel-related zinc finger protein 1 (Protein HKR1).