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Network neighborhood for query Sequence : ARHG9_HUMAN

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ARHG9_HUMAN
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARHG9_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	235
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0 (rank : 2)	NC score	0.999559 (rank : 2)
Query Neighborhood Hits	235	Target Neighborhood Hits	234	Shared Neighborhood Hits	231
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_HUMAN
θ value	6.99473e-178 (rank : 3)	NC score	0.977972 (rank : 3)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	211
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	1.46188e-167 (rank : 4)	NC score	0.976515 (rank : 4)
Query Neighborhood Hits	235	Target Neighborhood Hits	185	Shared Neighborhood Hits	168
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PREX1_HUMAN
θ value	7.75577e-52 (rank : 5)	NC score	0.820045 (rank : 5)
Query Neighborhood Hits	235	Target Neighborhood Hits	177	Shared Neighborhood Hits	74
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
θ value	1.6813e-30 (rank : 6)	NC score	0.807039 (rank : 6)
Query Neighborhood Hits	235	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

TIAM1_MOUSE
θ value	2.51237e-26 (rank : 7)	NC score	0.733611 (rank : 9)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
θ value	4.73814e-25 (rank : 8)	NC score	0.726841 (rank : 10)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
θ value	6.84181e-24 (rank : 9)	NC score	0.771175 (rank : 7)
Query Neighborhood Hits	235	Target Neighborhood Hits	347	Shared Neighborhood Hits	207
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	1.5242e-23 (rank : 10)	NC score	0.767417 (rank : 8)
Query Neighborhood Hits	235	Target Neighborhood Hits	396	Shared Neighborhood Hits	208
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ITSN1_HUMAN
θ value	2.87452e-22 (rank : 11)	NC score	0.548687 (rank : 48)
Query Neighborhood Hits	235	Target Neighborhood Hits	1757	Shared Neighborhood Hits	220
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
θ value	6.40375e-22 (rank : 12)	NC score	0.589344 (rank : 44)
Query Neighborhood Hits	235	Target Neighborhood Hits	1173	Shared Neighborhood Hits	217
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_MOUSE
θ value	8.36355e-22 (rank : 13)	NC score	0.548034 (rank : 49)
Query Neighborhood Hits	235	Target Neighborhood Hits	1669	Shared Neighborhood Hits	219
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV2_MOUSE
θ value	1.42661e-21 (rank : 14)	NC score	0.670274 (rank : 21)
Query Neighborhood Hits	235	Target Neighborhood Hits	456	Shared Neighborhood Hits	190
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
θ value	9.24701e-21 (rank : 15)	NC score	0.666292 (rank : 23)
Query Neighborhood Hits	235	Target Neighborhood Hits	453	Shared Neighborhood Hits	190
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

MCF2_HUMAN
θ value	2.69047e-20 (rank : 16)	NC score	0.717708 (rank : 12)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ITSN2_MOUSE
θ value	5.99374e-20 (rank : 17)	NC score	0.555760 (rank : 46)
Query Neighborhood Hits	235	Target Neighborhood Hits	1371	Shared Neighborhood Hits	216
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_HUMAN
θ value	5.99374e-20 (rank : 18)	NC score	0.665182 (rank : 24)
Query Neighborhood Hits	235	Target Neighborhood Hits	452	Shared Neighborhood Hits	197
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	1.74391e-19 (rank : 19)	NC score	0.675110 (rank : 19)
Query Neighborhood Hits	235	Target Neighborhood Hits	430	Shared Neighborhood Hits	200
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV3_MOUSE
θ value	6.62687e-19 (rank : 20)	NC score	0.651451 (rank : 28)
Query Neighborhood Hits	235	Target Neighborhood Hits	404	Shared Neighborhood Hits	189
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG6_HUMAN
θ value	9.56915e-18 (rank : 21)	NC score	0.719311 (rank : 11)
Query Neighborhood Hits	235	Target Neighborhood Hits	376	Shared Neighborhood Hits	189
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV3_HUMAN
θ value	1.24977e-17 (rank : 22)	NC score	0.649079 (rank : 29)
Query Neighborhood Hits	235	Target Neighborhood Hits	398	Shared Neighborhood Hits	190
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG6_MOUSE
θ value	3.63628e-17 (rank : 23)	NC score	0.704406 (rank : 14)
Query Neighborhood Hits	235	Target Neighborhood Hits	394	Shared Neighborhood Hits	189
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FARP2_MOUSE
θ value	6.20254e-17 (rank : 24)	NC score	0.482878 (rank : 60)
Query Neighborhood Hits	235	Target Neighborhood Hits	209	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD4_HUMAN
θ value	8.10077e-17 (rank : 25)	NC score	0.634380 (rank : 30)
Query Neighborhood Hits	235	Target Neighborhood Hits	219	Shared Neighborhood Hits	73
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FARP2_HUMAN
θ value	3.07829e-16 (rank : 26)	NC score	0.463146 (rank : 63)
Query Neighborhood Hits	235	Target Neighborhood Hits	240	Shared Neighborhood Hits	69
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

DUET_HUMAN
θ value	4.02038e-16 (rank : 27)	NC score	0.239887 (rank : 143)
Query Neighborhood Hits	235	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DNMBP_HUMAN
θ value	5.25075e-16 (rank : 28)	NC score	0.702463 (rank : 15)
Query Neighborhood Hits	235	Target Neighborhood Hits	413	Shared Neighborhood Hits	207
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MCF2L_MOUSE
θ value	8.95645e-16 (rank : 29)	NC score	0.691921 (rank : 16)
Query Neighborhood Hits	235	Target Neighborhood Hits	255	Shared Neighborhood Hits	91
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

DNMBP_MOUSE
θ value	1.99529e-15 (rank : 30)	NC score	0.711190 (rank : 13)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	205
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FARP1_HUMAN
θ value	1.99529e-15 (rank : 31)	NC score	0.418484 (rank : 69)
Query Neighborhood Hits	235	Target Neighborhood Hits	241	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TRIO_HUMAN
θ value	1.99529e-15 (rank : 32)	NC score	0.246609 (rank : 139)
Query Neighborhood Hits	235	Target Neighborhood Hits	1580	Shared Neighborhood Hits	124
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG3_HUMAN
θ value	2.60593e-15 (rank : 33)	NC score	0.683726 (rank : 17)
Query Neighborhood Hits	235	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	3.40345e-15 (rank : 34)	NC score	0.682891 (rank : 18)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

FGD4_MOUSE
θ value	3.40345e-15 (rank : 35)	NC score	0.632271 (rank : 31)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	75
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

SOS2_HUMAN
θ value	7.58209e-15 (rank : 36)	NC score	0.365234 (rank : 90)
Query Neighborhood Hits	235	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

HAPIP_HUMAN
θ value	1.29331e-14 (rank : 37)	NC score	0.572427 (rank : 45)
Query Neighborhood Hits	235	Target Neighborhood Hits	350	Shared Neighborhood Hits	77
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

SOS1_HUMAN
θ value	2.20605e-14 (rank : 38)	NC score	0.389594 (rank : 80)
Query Neighborhood Hits	235	Target Neighborhood Hits	274	Shared Neighborhood Hits	40
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	2.20605e-14 (rank : 39)	NC score	0.378399 (rank : 84)
Query Neighborhood Hits	235	Target Neighborhood Hits	281	Shared Neighborhood Hits	39
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHG8_MOUSE
θ value	2.88119e-14 (rank : 40)	NC score	0.661814 (rank : 25)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FGD1_MOUSE
θ value	4.91457e-14 (rank : 41)	NC score	0.591321 (rank : 42)
Query Neighborhood Hits	235	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG8_HUMAN
θ value	6.41864e-14 (rank : 42)	NC score	0.673195 (rank : 20)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD1_HUMAN
θ value	1.86753e-13 (rank : 43)	NC score	0.592309 (rank : 41)
Query Neighborhood Hits	235	Target Neighborhood Hits	367	Shared Neighborhood Hits	79
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	7.09661e-13 (rank : 44)	NC score	0.622880 (rank : 33)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	73
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	1.58096e-12 (rank : 45)	NC score	0.610530 (rank : 36)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ARHGB_HUMAN
θ value	2.0648e-12 (rank : 46)	NC score	0.553191 (rank : 47)
Query Neighborhood Hits	235	Target Neighborhood Hits	375	Shared Neighborhood Hits	79
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGA_MOUSE
θ value	2.69671e-12 (rank : 47)	NC score	0.605699 (rank : 38)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	62
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD3_MOUSE
θ value	2.69671e-12 (rank : 48)	NC score	0.653057 (rank : 27)
Query Neighborhood Hits	235	Target Neighborhood Hits	257	Shared Neighborhood Hits	71
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ECT2_MOUSE
θ value	3.89403e-11 (rank : 49)	NC score	0.669349 (rank : 22)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGC_HUMAN
θ value	5.08577e-11 (rank : 50)	NC score	0.527936 (rank : 52)
Query Neighborhood Hits	235	Target Neighborhood Hits	351	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

OBSCN_HUMAN
θ value	8.67504e-11 (rank : 51)	NC score	0.122536 (rank : 202)
Query Neighborhood Hits	235	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FGD3_HUMAN
θ value	1.47974e-10 (rank : 52)	NC score	0.628600 (rank : 32)
Query Neighborhood Hits	235	Target Neighborhood Hits	249	Shared Neighborhood Hits	70
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ECT2_HUMAN
θ value	2.52405e-10 (rank : 53)	NC score	0.657339 (rank : 26)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RGNEF_MOUSE
θ value	2.52405e-10 (rank : 54)	NC score	0.463601 (rank : 62)
Query Neighborhood Hits	235	Target Neighborhood Hits	641	Shared Neighborhood Hits	76
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGA_HUMAN
θ value	3.29651e-10 (rank : 55)	NC score	0.598217 (rank : 40)
Query Neighborhood Hits	235	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_HUMAN
θ value	3.29651e-10 (rank : 56)	NC score	0.619212 (rank : 34)
Query Neighborhood Hits	235	Target Neighborhood Hits	129	Shared Neighborhood Hits	90
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGC_MOUSE
θ value	4.30538e-10 (rank : 57)	NC score	0.519901 (rank : 54)
Query Neighborhood Hits	235	Target Neighborhood Hits	344	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGG_MOUSE
θ value	6.21693e-09 (rank : 58)	NC score	0.616698 (rank : 35)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	100
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD6_HUMAN
θ value	6.21693e-09 (rank : 59)	NC score	0.511693 (rank : 57)
Query Neighborhood Hits	235	Target Neighborhood Hits	237	Shared Neighborhood Hits	68
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHG1_HUMAN
θ value	5.26297e-08 (rank : 60)	NC score	0.543824 (rank : 50)
Query Neighborhood Hits	235	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ABR_HUMAN
θ value	8.97725e-08 (rank : 61)	NC score	0.394799 (rank : 77)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

FGD6_MOUSE
θ value	1.17247e-07 (rank : 62)	NC score	0.514669 (rank : 56)
Query Neighborhood Hits	235	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

STAC_HUMAN
θ value	3.41135e-07 (rank : 63)	NC score	0.417869 (rank : 70)
Query Neighborhood Hits	235	Target Neighborhood Hits	276	Shared Neighborhood Hits	152
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP2_MOUSE
θ value	5.81887e-07 (rank : 64)	NC score	0.375804 (rank : 85)
Query Neighborhood Hits	235	Target Neighborhood Hits	297	Shared Neighborhood Hits	162
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
θ value	9.92553e-07 (rank : 65)	NC score	0.373322 (rank : 86)
Query Neighborhood Hits	235	Target Neighborhood Hits	304	Shared Neighborhood Hits	162
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NGEF_HUMAN
θ value	9.92553e-07 (rank : 66)	NC score	0.606635 (rank : 37)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	117
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

STAC_MOUSE
θ value	9.92553e-07 (rank : 67)	NC score	0.406971 (rank : 74)
Query Neighborhood Hits	235	Target Neighborhood Hits	268	Shared Neighborhood Hits	152
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SPTA2_HUMAN
θ value	1.29631e-06 (rank : 68)	NC score	0.210293 (rank : 159)
Query Neighborhood Hits	235	Target Neighborhood Hits	888	Shared Neighborhood Hits	166
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ARHG2_MOUSE
θ value	1.69304e-06 (rank : 69)	NC score	0.521959 (rank : 53)
Query Neighborhood Hits	235	Target Neighborhood Hits	120	Shared Neighborhood Hits	64
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

STAM1_MOUSE
θ value	2.88788e-06 (rank : 70)	NC score	0.381556 (rank : 82)
Query Neighborhood Hits	235	Target Neighborhood Hits	273	Shared Neighborhood Hits	161
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF1_HUMAN
θ value	3.77169e-06 (rank : 71)	NC score	0.427349 (rank : 66)
Query Neighborhood Hits	235	Target Neighborhood Hits	198	Shared Neighborhood Hits	146
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NGEF_MOUSE
θ value	4.92598e-06 (rank : 72)	NC score	0.590019 (rank : 43)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	118
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG4_HUMAN
θ value	4.92598e-06 (rank : 73)	NC score	0.541783 (rank : 51)
Query Neighborhood Hits	235	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

STAM1_HUMAN
θ value	4.92598e-06 (rank : 74)	NC score	0.382655 (rank : 81)
Query Neighborhood Hits	235	Target Neighborhood Hits	271	Shared Neighborhood Hits	163
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GNRP_MOUSE
θ value	6.43352e-06 (rank : 75)	NC score	0.474302 (rank : 61)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	62
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

BCR_HUMAN
θ value	8.40245e-06 (rank : 76)	NC score	0.389910 (rank : 79)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

FGD5_HUMAN
θ value	8.40245e-06 (rank : 77)	NC score	0.379192 (rank : 83)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

SPTA1_HUMAN
θ value	8.40245e-06 (rank : 78)	NC score	0.200104 (rank : 171)
Query Neighborhood Hits	235	Target Neighborhood Hits	748	Shared Neighborhood Hits	149
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ASPP1_HUMAN
θ value	1.09739e-05 (rank : 79)	NC score	0.227358 (rank : 147)
Query Neighborhood Hits	235	Target Neighborhood Hits	956	Shared Neighborhood Hits	140
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NCF4_MOUSE
θ value	1.09739e-05 (rank : 80)	NC score	0.415236 (rank : 72)
Query Neighborhood Hits	235	Target Neighborhood Hits	177	Shared Neighborhood Hits	133
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SPTA1_MOUSE
θ value	1.09739e-05 (rank : 81)	NC score	0.205200 (rank : 165)
Query Neighborhood Hits	235	Target Neighborhood Hits	675	Shared Neighborhood Hits	139
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

LBC_HUMAN
θ value	1.43324e-05 (rank : 82)	NC score	0.506256 (rank : 58)
Query Neighborhood Hits	235	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

NCF4_HUMAN
θ value	1.43324e-05 (rank : 83)	NC score	0.411886 (rank : 73)
Query Neighborhood Hits	235	Target Neighborhood Hits	161	Shared Neighborhood Hits	123
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ARHGF_HUMAN
θ value	2.44474e-05 (rank : 84)	NC score	0.516650 (rank : 55)
Query Neighborhood Hits	235	Target Neighborhood Hits	214	Shared Neighborhood Hits	66
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASPP1_MOUSE
θ value	2.44474e-05 (rank : 85)	NC score	0.225194 (rank : 150)
Query Neighborhood Hits	235	Target Neighborhood Hits	1244	Shared Neighborhood Hits	145
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ARHG5_HUMAN
θ value	3.19293e-05 (rank : 86)	NC score	0.600638 (rank : 39)
Query Neighborhood Hits	235	Target Neighborhood Hits	172	Shared Neighborhood Hits	121
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

AHI1_HUMAN
θ value	4.1701e-05 (rank : 87)	NC score	0.281919 (rank : 124)
Query Neighborhood Hits	235	Target Neighborhood Hits	537	Shared Neighborhood Hits	156
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

STAM2_HUMAN
θ value	5.44631e-05 (rank : 88)	NC score	0.361965 (rank : 93)
Query Neighborhood Hits	235	Target Neighborhood Hits	288	Shared Neighborhood Hits	159
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

NCF1_MOUSE
θ value	7.1131e-05 (rank : 89)	NC score	0.406087 (rank : 75)
Query Neighborhood Hits	235	Target Neighborhood Hits	198	Shared Neighborhood Hits	145
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CD2AP_HUMAN
θ value	9.29e-05 (rank : 90)	NC score	0.420182 (rank : 68)
Query Neighborhood Hits	235	Target Neighborhood Hits	315	Shared Neighborhood Hits	156
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

STAM2_MOUSE
θ value	9.29e-05 (rank : 91)	NC score	0.367717 (rank : 88)
Query Neighborhood Hits	235	Target Neighborhood Hits	285	Shared Neighborhood Hits	159
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

AHI1_MOUSE
θ value	0.000158464 (rank : 92)	NC score	0.275293 (rank : 127)
Query Neighborhood Hits	235	Target Neighborhood Hits	496	Shared Neighborhood Hits	159
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ASPP2_HUMAN
θ value	0.000158464 (rank : 93)	NC score	0.183879 (rank : 176)
Query Neighborhood Hits	235	Target Neighborhood Hits	1156	Shared Neighborhood Hits	135
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

HCLS1_MOUSE
θ value	0.000786445 (rank : 94)	NC score	0.363462 (rank : 92)
Query Neighborhood Hits	235	Target Neighborhood Hits	329	Shared Neighborhood Hits	143
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

RHG04_HUMAN
θ value	0.000786445 (rank : 95)	NC score	0.240920 (rank : 142)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	143
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SH3G1_HUMAN
θ value	0.000786445 (rank : 96)	NC score	0.334659 (rank : 109)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	147
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAC3_HUMAN
θ value	0.000786445 (rank : 97)	NC score	0.367476 (rank : 89)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	132
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.000786445 (rank : 98)	NC score	0.369829 (rank : 87)
Query Neighborhood Hits	235	Target Neighborhood Hits	232	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRB2_HUMAN
θ value	0.00102713 (rank : 99)	NC score	0.359193 (rank : 95)
Query Neighborhood Hits	235	Target Neighborhood Hits	310	Shared Neighborhood Hits	162
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00102713 (rank : 100)	NC score	0.359061 (rank : 96)
Query Neighborhood Hits	235	Target Neighborhood Hits	312	Shared Neighborhood Hits	162
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SH3K1_HUMAN
θ value	0.00102713 (rank : 101)	NC score	0.430790 (rank : 65)
Query Neighborhood Hits	235	Target Neighborhood Hits	341	Shared Neighborhood Hits	154
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.00102713 (rank : 102)	NC score	0.420263 (rank : 67)
Query Neighborhood Hits	235	Target Neighborhood Hits	332	Shared Neighborhood Hits	156
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

GRAP_HUMAN
θ value	0.00175202 (rank : 103)	NC score	0.360543 (rank : 94)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

HCLS1_HUMAN
θ value	0.00175202 (rank : 104)	NC score	0.364947 (rank : 91)
Query Neighborhood Hits	235	Target Neighborhood Hits	358	Shared Neighborhood Hits	147
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

IASPP_MOUSE
θ value	0.00175202 (rank : 105)	NC score	0.212943 (rank : 157)
Query Neighborhood Hits	235	Target Neighborhood Hits	1024	Shared Neighborhood Hits	144
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ARHG2_HUMAN
θ value	0.00228821 (rank : 106)	NC score	0.487747 (rank : 59)
Query Neighborhood Hits	235	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

IASPP_HUMAN
θ value	0.00228821 (rank : 107)	NC score	0.224235 (rank : 151)
Query Neighborhood Hits	235	Target Neighborhood Hits	688	Shared Neighborhood Hits	139
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

BCAR1_HUMAN
θ value	0.00390308 (rank : 108)	NC score	0.261421 (rank : 134)
Query Neighborhood Hits	235	Target Neighborhood Hits	554	Shared Neighborhood Hits	145
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0.00390308 (rank : 109)	NC score	0.269736 (rank : 132)
Query Neighborhood Hits	235	Target Neighborhood Hits	438	Shared Neighborhood Hits	144
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CD2AP_MOUSE
θ value	0.00390308 (rank : 110)	NC score	0.415611 (rank : 71)
Query Neighborhood Hits	235	Target Neighborhood Hits	336	Shared Neighborhood Hits	159
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3G1_MOUSE
θ value	0.00390308 (rank : 111)	NC score	0.333973 (rank : 110)
Query Neighborhood Hits	235	Target Neighborhood Hits	291	Shared Neighborhood Hits	150
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

TCGAP_MOUSE
θ value	0.00390308 (rank : 112)	NC score	0.206764 (rank : 161)
Query Neighborhood Hits	235	Target Neighborhood Hits	409	Shared Neighborhood Hits	123
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_HUMAN
θ value	0.00509761 (rank : 113)	NC score	0.187507 (rank : 174)
Query Neighborhood Hits	235	Target Neighborhood Hits	872	Shared Neighborhood Hits	129
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SH3G2_MOUSE
θ value	0.00665767 (rank : 114)	NC score	0.331576 (rank : 111)
Query Neighborhood Hits	235	Target Neighborhood Hits	319	Shared Neighborhood Hits	154
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ANM2_HUMAN
θ value	0.00869519 (rank : 115)	NC score	0.234731 (rank : 146)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	128
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BI2L1_HUMAN
θ value	0.00869519 (rank : 116)	NC score	0.192538 (rank : 173)
Query Neighborhood Hits	235	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

MYO1F_MOUSE
θ value	0.00869519 (rank : 117)	NC score	0.154845 (rank : 188)
Query Neighborhood Hits	235	Target Neighborhood Hits	262	Shared Neighborhood Hits	149
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NPHP1_MOUSE
θ value	0.00869519 (rank : 118)	NC score	0.289626 (rank : 121)
Query Neighborhood Hits	235	Target Neighborhood Hits	267	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

DDEF2_MOUSE
θ value	0.0113563 (rank : 119)	NC score	0.171144 (rank : 179)
Query Neighborhood Hits	235	Target Neighborhood Hits	625	Shared Neighborhood Hits	134
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP_MOUSE
θ value	0.0113563 (rank : 120)	NC score	0.357455 (rank : 97)
Query Neighborhood Hits	235	Target Neighborhood Hits	309	Shared Neighborhood Hits	165
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PTK6_HUMAN
θ value	0.0113563 (rank : 121)	NC score	0.075662 (rank : 268)
Query Neighborhood Hits	235	Target Neighborhood Hits	1020	Shared Neighborhood Hits	135
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SH3G3_HUMAN
θ value	0.0113563 (rank : 122)	NC score	0.337846 (rank : 106)
Query Neighborhood Hits	235	Target Neighborhood Hits	222	Shared Neighborhood Hits	146
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRGP1_HUMAN
θ value	0.0113563 (rank : 123)	NC score	0.201769 (rank : 167)
Query Neighborhood Hits	235	Target Neighborhood Hits	390	Shared Neighborhood Hits	132
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

CASL_MOUSE
θ value	0.0148317 (rank : 124)	NC score	0.249397 (rank : 138)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	126
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

FNBP2_HUMAN
θ value	0.0148317 (rank : 125)	NC score	0.195340 (rank : 172)
Query Neighborhood Hits	235	Target Neighborhood Hits	432	Shared Neighborhood Hits	130
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

M3K9_HUMAN
θ value	0.0148317 (rank : 126)	NC score	0.094781 (rank : 223)
Query Neighborhood Hits	235	Target Neighborhood Hits	1123	Shared Neighborhood Hits	152
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MYO1F_HUMAN
θ value	0.0148317 (rank : 127)	NC score	0.153076 (rank : 191)
Query Neighborhood Hits	235	Target Neighborhood Hits	275	Shared Neighborhood Hits	149
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SHAN1_HUMAN
θ value	0.0148317 (rank : 128)	NC score	0.149857 (rank : 192)
Query Neighborhood Hits	235	Target Neighborhood Hits	1041	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SH3G2_HUMAN
θ value	0.0193708 (rank : 129)	NC score	0.335916 (rank : 108)
Query Neighborhood Hits	235	Target Neighborhood Hits	324	Shared Neighborhood Hits	155
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SRGP2_MOUSE
θ value	0.0193708 (rank : 130)	NC score	0.205564 (rank : 164)
Query Neighborhood Hits	235	Target Neighborhood Hits	324	Shared Neighborhood Hits	137
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CASL_HUMAN
θ value	0.0252991 (rank : 131)	NC score	0.253291 (rank : 136)
Query Neighborhood Hits	235	Target Neighborhood Hits	259	Shared Neighborhood Hits	128
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DDEF2_HUMAN
θ value	0.0252991 (rank : 132)	NC score	0.168151 (rank : 183)
Query Neighborhood Hits	235	Target Neighborhood Hits	599	Shared Neighborhood Hits	135
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SH3G3_MOUSE
θ value	0.0252991 (rank : 133)	NC score	0.341181 (rank : 103)
Query Neighborhood Hits	235	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRC8_MOUSE
θ value	0.0252991 (rank : 134)	NC score	0.345936 (rank : 100)
Query Neighborhood Hits	235	Target Neighborhood Hits	292	Shared Neighborhood Hits	146
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

M3K11_HUMAN
θ value	0.0431538 (rank : 135)	NC score	0.095705 (rank : 221)
Query Neighborhood Hits	235	Target Neighborhood Hits	1136	Shared Neighborhood Hits	152
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SRC8_HUMAN
θ value	0.0431538 (rank : 136)	NC score	0.348634 (rank : 98)
Query Neighborhood Hits	235	Target Neighborhood Hits	269	Shared Neighborhood Hits	144
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRGP2_HUMAN
θ value	0.0431538 (rank : 137)	NC score	0.201562 (rank : 168)
Query Neighborhood Hits	235	Target Neighborhood Hits	331	Shared Neighborhood Hits	135
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ANM2_MOUSE
θ value	0.0563607 (rank : 138)	NC score	0.220929 (rank : 153)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FRK_HUMAN
θ value	0.0563607 (rank : 139)	NC score	0.080205 (rank : 251)
Query Neighborhood Hits	235	Target Neighborhood Hits	1058	Shared Neighborhood Hits	155
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PACN2_MOUSE
θ value	0.0563607 (rank : 140)	NC score	0.272156 (rank : 130)
Query Neighborhood Hits	235	Target Neighborhood Hits	382	Shared Neighborhood Hits	159
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

BTK_HUMAN
θ value	0.0736092 (rank : 141)	NC score	0.087109 (rank : 241)
Query Neighborhood Hits	235	Target Neighborhood Hits	1026	Shared Neighborhood Hits	144
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

MYO1E_HUMAN
θ value	0.0736092 (rank : 142)	NC score	0.149677 (rank : 194)
Query Neighborhood Hits	235	Target Neighborhood Hits	293	Shared Neighborhood Hits	149
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PACN2_HUMAN
θ value	0.0736092 (rank : 143)	NC score	0.274170 (rank : 129)
Query Neighborhood Hits	235	Target Neighborhood Hits	339	Shared Neighborhood Hits	154
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PTK6_MOUSE
θ value	0.0736092 (rank : 144)	NC score	0.076413 (rank : 265)
Query Neighborhood Hits	235	Target Neighborhood Hits	1026	Shared Neighborhood Hits	134
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

DDEF1_MOUSE
θ value	0.0961366 (rank : 145)	NC score	0.170283 (rank : 180)
Query Neighborhood Hits	235	Target Neighborhood Hits	592	Shared Neighborhood Hits	126
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

M3KL4_HUMAN
θ value	0.0961366 (rank : 146)	NC score	0.099556 (rank : 218)
Query Neighborhood Hits	235	Target Neighborhood Hits	1087	Shared Neighborhood Hits	145
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

NCF2_HUMAN
θ value	0.0961366 (rank : 147)	NC score	0.391135 (rank : 78)
Query Neighborhood Hits	235	Target Neighborhood Hits	229	Shared Neighborhood Hits	146
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK2_HUMAN
θ value	0.0961366 (rank : 148)	NC score	0.328941 (rank : 112)
Query Neighborhood Hits	235	Target Neighborhood Hits	310	Shared Neighborhood Hits	152
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

BI2L1_MOUSE
θ value	0.125558 (rank : 149)	NC score	0.154139 (rank : 190)
Query Neighborhood Hits	235	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

OSTF1_HUMAN
θ value	0.125558 (rank : 150)	NC score	0.278722 (rank : 125)
Query Neighborhood Hits	235	Target Neighborhood Hits	466	Shared Neighborhood Hits	156
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	0.125558 (rank : 151)	NC score	0.274469 (rank : 128)
Query Neighborhood Hits	235	Target Neighborhood Hits	467	Shared Neighborhood Hits	155
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

FYN_HUMAN
θ value	0.21417 (rank : 152)	NC score	0.095981 (rank : 220)
Query Neighborhood Hits	235	Target Neighborhood Hits	1078	Shared Neighborhood Hits	158
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.21417 (rank : 153)	NC score	0.098238 (rank : 219)
Query Neighborhood Hits	235	Target Neighborhood Hits	1073	Shared Neighborhood Hits	158
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ABI1_MOUSE
θ value	0.279714 (rank : 154)	NC score	0.303223 (rank : 115)
Query Neighborhood Hits	235	Target Neighborhood Hits	246	Shared Neighborhood Hits	155
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CRKL_HUMAN
θ value	0.279714 (rank : 155)	NC score	0.298418 (rank : 117)
Query Neighborhood Hits	235	Target Neighborhood Hits	313	Shared Neighborhood Hits	156
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NCK1_HUMAN
θ value	0.279714 (rank : 156)	NC score	0.340482 (rank : 105)
Query Neighborhood Hits	235	Target Neighborhood Hits	312	Shared Neighborhood Hits	162
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRKL_MOUSE
θ value	0.365318 (rank : 157)	NC score	0.290198 (rank : 120)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	152
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PPIP1_MOUSE
θ value	0.365318 (rank : 158)	NC score	0.297585 (rank : 118)
Query Neighborhood Hits	235	Target Neighborhood Hits	377	Shared Neighborhood Hits	159
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ABI2_HUMAN
θ value	0.47712 (rank : 159)	NC score	0.311619 (rank : 114)
Query Neighborhood Hits	235	Target Neighborhood Hits	350	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.47712 (rank : 160)	NC score	0.313299 (rank : 113)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	156
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BAIP2_HUMAN
θ value	0.47712 (rank : 161)	NC score	0.131164 (rank : 199)
Query Neighborhood Hits	235	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	0.47712 (rank : 162)	NC score	0.133188 (rank : 198)
Query Neighborhood Hits	235	Target Neighborhood Hits	185	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

PPIP1_HUMAN
θ value	0.47712 (rank : 163)	NC score	0.298938 (rank : 116)
Query Neighborhood Hits	235	Target Neighborhood Hits	389	Shared Neighborhood Hits	159
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

DLG4_HUMAN
θ value	0.62314 (rank : 164)	NC score	0.059411 (rank : 320)
Query Neighborhood Hits	235	Target Neighborhood Hits	286	Shared Neighborhood Hits	77
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

M3K10_HUMAN
θ value	0.62314 (rank : 165)	NC score	0.077981 (rank : 260)
Query Neighborhood Hits	235	Target Neighborhood Hits	1071	Shared Neighborhood Hits	136
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

RIMB1_MOUSE
θ value	0.62314 (rank : 166)	NC score	0.102936 (rank : 216)
Query Neighborhood Hits	235	Target Neighborhood Hits	1376	Shared Neighborhood Hits	134
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUSC1_HUMAN
θ value	0.62314 (rank : 167)	NC score	0.168837 (rank : 181)
Query Neighborhood Hits	235	Target Neighborhood Hits	226	Shared Neighborhood Hits	116
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SHAN2_MOUSE
θ value	0.62314 (rank : 168)	NC score	0.182223 (rank : 177)
Query Neighborhood Hits	235	Target Neighborhood Hits	446	Shared Neighborhood Hits	107
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRBS1_HUMAN
θ value	0.62314 (rank : 169)	NC score	0.343783 (rank : 101)
Query Neighborhood Hits	235	Target Neighborhood Hits	396	Shared Neighborhood Hits	155
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

DBNL_HUMAN
θ value	0.813845 (rank : 170)	NC score	0.277338 (rank : 126)
Query Neighborhood Hits	235	Target Neighborhood Hits	244	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.813845 (rank : 171)	NC score	0.271722 (rank : 131)
Query Neighborhood Hits	235	Target Neighborhood Hits	306	Shared Neighborhood Hits	126
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NOXO1_HUMAN
θ value	0.813845 (rank : 172)	NC score	0.205901 (rank : 162)
Query Neighborhood Hits	235	Target Neighborhood Hits	100	Shared Neighborhood Hits	79
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ABI1_HUMAN
θ value	1.06291 (rank : 173)	NC score	0.285101 (rank : 123)
Query Neighborhood Hits	235	Target Neighborhood Hits	257	Shared Neighborhood Hits	154
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

HCK_HUMAN
θ value	1.06291 (rank : 174)	NC score	0.079986 (rank : 252)
Query Neighborhood Hits	235	Target Neighborhood Hits	1035	Shared Neighborhood Hits	145
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

PACN1_HUMAN
θ value	1.06291 (rank : 175)	NC score	0.253764 (rank : 135)
Query Neighborhood Hits	235	Target Neighborhood Hits	320	Shared Neighborhood Hits	157
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	1.06291 (rank : 176)	NC score	0.252768 (rank : 137)
Query Neighborhood Hits	235	Target Neighborhood Hits	283	Shared Neighborhood Hits	155
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PEX13_MOUSE
θ value	1.06291 (rank : 177)	NC score	0.215361 (rank : 156)
Query Neighborhood Hits	235	Target Neighborhood Hits	126	Shared Neighborhood Hits	96
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC1_MOUSE
θ value	1.06291 (rank : 178)	NC score	0.163956 (rank : 184)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SRC_HUMAN
θ value	1.06291 (rank : 179)	NC score	0.090990 (rank : 232)
Query Neighborhood Hits	235	Target Neighborhood Hits	1058	Shared Neighborhood Hits	153
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_HUMAN
θ value	1.06291 (rank : 180)	NC score	0.094496 (rank : 224)
Query Neighborhood Hits	235	Target Neighborhood Hits	1059	Shared Neighborhood Hits	152
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	1.06291 (rank : 181)	NC score	0.095312 (rank : 222)
Query Neighborhood Hits	235	Target Neighborhood Hits	1052	Shared Neighborhood Hits	152
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CT032_HUMAN
θ value	1.38821 (rank : 182)	NC score	0.264634 (rank : 133)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DLG4_MOUSE
θ value	1.38821 (rank : 183)	NC score	0.056237 (rank : 333)
Query Neighborhood Hits	235	Target Neighborhood Hits	282	Shared Neighborhood Hits	74
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

EFS_HUMAN
θ value	1.38821 (rank : 184)	NC score	0.223206 (rank : 152)
Query Neighborhood Hits	235	Target Neighborhood Hits	348	Shared Neighborhood Hits	128
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	1.38821 (rank : 185)	NC score	0.227309 (rank : 148)
Query Neighborhood Hits	235	Target Neighborhood Hits	389	Shared Neighborhood Hits	132
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

IF3A_HUMAN
θ value	1.38821 (rank : 186)	NC score	0.033112 (rank : 375)
Query Neighborhood Hits	235	Target Neighborhood Hits	875	Shared Neighborhood Hits	23
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

K0423_HUMAN
θ value	1.38821 (rank : 187)	NC score	0.024112 (rank : 379)
Query Neighborhood Hits	235	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

TBCD7_MOUSE
θ value	1.38821 (rank : 188)	NC score	0.028768 (rank : 378)
Query Neighborhood Hits	235	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D0K0, Q3U0V0	Gene names	Tbc1d7
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 7.

TEC_MOUSE
θ value	1.38821 (rank : 189)	NC score	0.059011 (rank : 323)
Query Neighborhood Hits	235	Target Neighborhood Hits	1006	Shared Neighborhood Hits	117
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VINEX_MOUSE
θ value	1.38821 (rank : 190)	NC score	0.346069 (rank : 99)
Query Neighborhood Hits	235	Target Neighborhood Hits	286	Shared Neighborhood Hits	156
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

AKAP9_HUMAN
θ value	1.81305 (rank : 191)	NC score	0.030535 (rank : 376)
Query Neighborhood Hits	235	Target Neighborhood Hits	1710	Shared Neighborhood Hits	52
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

CSKP_MOUSE
θ value	1.81305 (rank : 192)	NC score	0.042348 (rank : 370)
Query Neighborhood Hits	235	Target Neighborhood Hits	1027	Shared Neighborhood Hits	115
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EM55_HUMAN
θ value	1.81305 (rank : 193)	NC score	0.090395 (rank : 234)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

IF3A_MOUSE
θ value	1.81305 (rank : 194)	NC score	0.034459 (rank : 374)
Query Neighborhood Hits	235	Target Neighborhood Hits	871	Shared Neighborhood Hits	25
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

ITK_HUMAN
θ value	1.81305 (rank : 195)	NC score	0.055173 (rank : 345)
Query Neighborhood Hits	235	Target Neighborhood Hits	1016	Shared Neighborhood Hits	116
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	1.81305 (rank : 196)	NC score	0.049357 (rank : 369)
Query Neighborhood Hits	235	Target Neighborhood Hits	985	Shared Neighborhood Hits	100
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

RIMB1_HUMAN
θ value	1.81305 (rank : 197)	NC score	0.108431 (rank : 211)
Query Neighborhood Hits	235	Target Neighborhood Hits	1479	Shared Neighborhood Hits	129
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRBS1_MOUSE
θ value	1.81305 (rank : 198)	NC score	0.340671 (rank : 104)
Query Neighborhood Hits	235	Target Neighborhood Hits	409	Shared Neighborhood Hits	153
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CSKP_HUMAN
θ value	2.36792 (rank : 199)	NC score	0.041934 (rank : 371)
Query Neighborhood Hits	235	Target Neighborhood Hits	1022	Shared Neighborhood Hits	109
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DLG2_HUMAN
θ value	2.36792 (rank : 200)	NC score	0.060129 (rank : 314)
Query Neighborhood Hits	235	Target Neighborhood Hits	279	Shared Neighborhood Hits	77
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	2.36792 (rank : 201)	NC score	0.061139 (rank : 307)
Query Neighborhood Hits	235	Target Neighborhood Hits	271	Shared Neighborhood Hits	78
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

EM55_MOUSE
θ value	2.36792 (rank : 202)	NC score	0.085723 (rank : 242)
Query Neighborhood Hits	235	Target Neighborhood Hits	221	Shared Neighborhood Hits	88
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FGR_MOUSE
θ value	2.36792 (rank : 203)	NC score	0.089465 (rank : 238)
Query Neighborhood Hits	235	Target Neighborhood Hits	1069	Shared Neighborhood Hits	151
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HS105_MOUSE
θ value	2.36792 (rank : 204)	NC score	0.011607 (rank : 382)
Query Neighborhood Hits	235	Target Neighborhood Hits	129	Shared Neighborhood Hits	9
SwissProt Accessions	Q61699, Q3TNS2, Q3UIY8, Q62578, Q62579, Q6A0A5, Q8C430, Q8VCW6	Gene names	Hsph1, Hsp105, Hsp110, Kiaa0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock-related 100 kDa protein E7I) (HSP-E7I) (Heat shock 110 kDa protein) (42 degrees C-HSP).

VINEX_HUMAN
θ value	2.36792 (rank : 205)	NC score	0.343408 (rank : 102)
Query Neighborhood Hits	235	Target Neighborhood Hits	270	Shared Neighborhood Hits	151
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABL1_HUMAN
θ value	3.0926 (rank : 206)	NC score	0.066077 (rank : 289)
Query Neighborhood Hits	235	Target Neighborhood Hits	1220	Shared Neighborhood Hits	108
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	3.0926 (rank : 207)	NC score	0.065667 (rank : 291)
Query Neighborhood Hits	235	Target Neighborhood Hits	1178	Shared Neighborhood Hits	106
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CRK_HUMAN
θ value	3.0926 (rank : 208)	NC score	0.286121 (rank : 122)
Query Neighborhood Hits	235	Target Neighborhood Hits	308	Shared Neighborhood Hits	157
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	3.0926 (rank : 209)	NC score	0.291297 (rank : 119)
Query Neighborhood Hits	235	Target Neighborhood Hits	314	Shared Neighborhood Hits	158
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

HCK_MOUSE
θ value	3.0926 (rank : 210)	NC score	0.078828 (rank : 254)
Query Neighborhood Hits	235	Target Neighborhood Hits	1029	Shared Neighborhood Hits	145
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

INCE_MOUSE
θ value	3.0926 (rank : 211)	NC score	0.030443 (rank : 377)
Query Neighborhood Hits	235	Target Neighborhood Hits	903	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

NPHP1_HUMAN
θ value	3.0926 (rank : 212)	NC score	0.227103 (rank : 149)
Query Neighborhood Hits	235	Target Neighborhood Hits	288	Shared Neighborhood Hits	131
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN3_HUMAN
θ value	3.0926 (rank : 213)	NC score	0.235082 (rank : 145)
Query Neighborhood Hits	235	Target Neighborhood Hits	385	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	3.0926 (rank : 214)	NC score	0.237444 (rank : 144)
Query Neighborhood Hits	235	Target Neighborhood Hits	380	Shared Neighborhood Hits	149
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

RUSC2_HUMAN
θ value	3.0926 (rank : 215)	NC score	0.091735 (rank : 230)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SYNE1_HUMAN
θ value	3.0926 (rank : 216)	NC score	0.041620 (rank : 372)
Query Neighborhood Hits	235	Target Neighborhood Hits	1484	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

NEBU_HUMAN
θ value	4.03905 (rank : 217)	NC score	0.184678 (rank : 175)
Query Neighborhood Hits	235	Target Neighborhood Hits	420	Shared Neighborhood Hits	142
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PEX13_HUMAN
θ value	4.03905 (rank : 218)	NC score	0.208285 (rank : 160)
Query Neighborhood Hits	235	Target Neighborhood Hits	128	Shared Neighborhood Hits	96
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC2_MOUSE
θ value	4.03905 (rank : 219)	NC score	0.081404 (rank : 249)
Query Neighborhood Hits	235	Target Neighborhood Hits	305	Shared Neighborhood Hits	60
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

DLG1_HUMAN
θ value	5.27518 (rank : 220)	NC score	0.054849 (rank : 346)
Query Neighborhood Hits	235	Target Neighborhood Hits	290	Shared Neighborhood Hits	71
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG3_HUMAN
θ value	5.27518 (rank : 221)	NC score	0.055996 (rank : 336)
Query Neighborhood Hits	235	Target Neighborhood Hits	269	Shared Neighborhood Hits	75
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	5.27518 (rank : 222)	NC score	0.056152 (rank : 334)
Query Neighborhood Hits	235	Target Neighborhood Hits	274	Shared Neighborhood Hits	75
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

HS105_HUMAN
θ value	5.27518 (rank : 223)	NC score	0.007768 (rank : 384)
Query Neighborhood Hits	235	Target Neighborhood Hits	209	Shared Neighborhood Hits	8
SwissProt Accessions	Q92598, O95739, Q5TBM6, Q5TBM8, Q9UPC4	Gene names	HSPH1, HSP105, HSP110, KIAA0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY- CO-25).

PAX4_HUMAN
θ value	5.27518 (rank : 224)	NC score	-0.002904 (rank : 387)
Query Neighborhood Hits	235	Target Neighborhood Hits	367	Shared Neighborhood Hits	2
SwissProt Accessions	O43316, O95161, Q6B0H0	Gene names	PAX4
Domain Architecture
Description	Paired box protein Pax-4.

SPN90_HUMAN
θ value	5.27518 (rank : 225)	NC score	0.119509 (rank : 204)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

CACB2_HUMAN
θ value	6.88961 (rank : 226)	NC score	0.014646 (rank : 381)
Query Neighborhood Hits	235	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

CACB2_MOUSE
θ value	6.88961 (rank : 227)	NC score	0.016206 (rank : 380)
Query Neighborhood Hits	235	Target Neighborhood Hits	94	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

BIN1_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.078109 (rank : 258)
Query Neighborhood Hits	235	Target Neighborhood Hits	335	Shared Neighborhood Hits	67
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	8.99809 (rank : 229)	NC score	0.077608 (rank : 261)
Query Neighborhood Hits	235	Target Neighborhood Hits	283	Shared Neighborhood Hits	73
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

EDNRA_MOUSE
θ value	8.99809 (rank : 230)	NC score	-0.005373 (rank : 388)
Query Neighborhood Hits	235	Target Neighborhood Hits	558	Shared Neighborhood Hits	4
SwissProt Accessions	Q61614, O54993, Q91VV2	Gene names	Ednra, Gpcr10
Domain Architecture
Description	Endothelin-1 receptor precursor (Endothelin A receptor) (ET-A) (ET- AR).

LYN_HUMAN
θ value	8.99809 (rank : 231)	NC score	0.069941 (rank : 274)
Query Neighborhood Hits	235	Target Neighborhood Hits	1022	Shared Neighborhood Hits	130
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MATK_HUMAN
θ value	8.99809 (rank : 232)	NC score	0.041478 (rank : 373)
Query Neighborhood Hits	235	Target Neighborhood Hits	954	Shared Neighborhood Hits	68
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

NCOA3_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.005275 (rank : 386)
Query Neighborhood Hits	235	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	8.99809 (rank : 234)	NC score	0.008841 (rank : 383)
Query Neighborhood Hits	235	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

SEP11_MOUSE
θ value	8.99809 (rank : 235)	NC score	0.007701 (rank : 385)
Query Neighborhood Hits	235	Target Neighborhood Hits	300	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C1B7, Q6P2K5, Q6P6I0	Gene names	Sept11, D5Ertd606e
Domain Architecture	No domain graphic available
Description	Septin-11.

ABI3_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.245115 (rank : 141)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	119
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.246552 (rank : 140)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL2_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.061106 (rank : 308)
Query Neighborhood Hits	235	Target Neighborhood Hits	1045	Shared Neighborhood Hits	98
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ALS2_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.050639 (rank : 362)
Query Neighborhood Hits	235	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.056996 (rank : 330)
Query Neighborhood Hits	235	Target Neighborhood Hits	111	Shared Neighborhood Hits	17
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

AMPH_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.092323 (rank : 229)
Query Neighborhood Hits	235	Target Neighborhood Hits	455	Shared Neighborhood Hits	78
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.089905 (rank : 237)
Query Neighborhood Hits	235	Target Neighborhood Hits	291	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

APS_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.059822 (rank : 316)
Query Neighborhood Hits	235	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.457580 (rank : 64)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

BLK_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.068091 (rank : 281)
Query Neighborhood Hits	235	Target Neighborhood Hits	994	Shared Neighborhood Hits	115
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.064858 (rank : 294)
Query Neighborhood Hits	235	Target Neighborhood Hits	992	Shared Neighborhood Hits	106
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.078053 (rank : 259)
Query Neighborhood Hits	235	Target Neighborhood Hits	1017	Shared Neighborhood Hits	137
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CHIN_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.077524 (rank : 262)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.078204 (rank : 257)
Query Neighborhood Hits	235	Target Neighborhood Hits	229	Shared Neighborhood Hits	44
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.076974 (rank : 263)
Query Neighborhood Hits	235	Target Neighborhood Hits	220	Shared Neighborhood Hits	41
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.065591 (rank : 292)
Query Neighborhood Hits	235	Target Neighborhood Hits	130	Shared Neighborhood Hits	20
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.067731 (rank : 284)
Query Neighborhood Hits	235	Target Neighborhood Hits	374	Shared Neighborhood Hits	62
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CNN1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.059726 (rank : 317)
Query Neighborhood Hits	235	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.059622 (rank : 318)
Query Neighborhood Hits	235	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.055302 (rank : 342)
Query Neighborhood Hits	235	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN2_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.059064 (rank : 322)
Query Neighborhood Hits	235	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN3_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.056242 (rank : 332)
Query Neighborhood Hits	235	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.056369 (rank : 331)
Query Neighborhood Hits	235	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CSK_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.062257 (rank : 305)
Query Neighborhood Hits	235	Target Neighborhood Hits	1009	Shared Neighborhood Hits	108
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.062428 (rank : 303)
Query Neighborhood Hits	235	Target Neighborhood Hits	1009	Shared Neighborhood Hits	108
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPP1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.067513 (rank : 286)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.067041 (rank : 287)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DOCK1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.084043 (rank : 247)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	100
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

EEA1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.051700 (rank : 359)
Query Neighborhood Hits	235	Target Neighborhood Hits	1796	Shared Neighborhood Hits	57
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.053927 (rank : 351)
Query Neighborhood Hits	235	Target Neighborhood Hits	1637	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EPS8_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.107603 (rank : 213)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	90
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.113224 (rank : 208)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.100303 (rank : 217)
Query Neighborhood Hits	235	Target Neighborhood Hits	162	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.102979 (rank : 215)
Query Neighborhood Hits	235	Target Neighborhood Hits	143	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.113636 (rank : 207)
Query Neighborhood Hits	235	Target Neighborhood Hits	193	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.109862 (rank : 209)
Query Neighborhood Hits	235	Target Neighborhood Hits	169	Shared Neighborhood Hits	98
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.125898 (rank : 200)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.136982 (rank : 197)
Query Neighborhood Hits	235	Target Neighborhood Hits	168	Shared Neighborhood Hits	112
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGD5_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.337843 (rank : 107)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGR_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.090138 (rank : 236)
Query Neighborhood Hits	235	Target Neighborhood Hits	1067	Shared Neighborhood Hits	153
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYV1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.057466 (rank : 328)
Query Neighborhood Hits	235	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.055696 (rank : 340)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GNRP_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.400491 (rank : 76)
Query Neighborhood Hits	235	Target Neighborhood Hits	239	Shared Neighborhood Hits	59
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GRB14_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.055854 (rank : 339)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.055890 (rank : 338)
Query Neighborhood Hits	235	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.052696 (rank : 354)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRP3_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.093171 (rank : 228)
Query Neighborhood Hits	235	Target Neighborhood Hits	131	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HGS_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.093984 (rank : 225)
Query Neighborhood Hits	235	Target Neighborhood Hits	517	Shared Neighborhood Hits	31
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.093227 (rank : 227)
Query Neighborhood Hits	235	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSH2D_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.050353 (rank : 364)
Query Neighborhood Hits	235	Target Neighborhood Hits	159	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LASP1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.220633 (rank : 154)
Query Neighborhood Hits	235	Target Neighborhood Hits	293	Shared Neighborhood Hits	134
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.217332 (rank : 155)
Query Neighborhood Hits	235	Target Neighborhood Hits	297	Shared Neighborhood Hits	132
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LCK_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.053298 (rank : 352)
Query Neighborhood Hits	235	Target Neighborhood Hits	987	Shared Neighborhood Hits	97
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.053028 (rank : 353)
Query Neighborhood Hits	235	Target Neighborhood Hits	981	Shared Neighborhood Hits	96
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LMO7_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.080654 (rank : 250)
Query Neighborhood Hits	235	Target Neighborhood Hits	507	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LNK_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.058552 (rank : 325)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.057661 (rank : 326)
Query Neighborhood Hits	235	Target Neighborhood Hits	132	Shared Neighborhood Hits	33
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LYN_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.067931 (rank : 283)
Query Neighborhood Hits	235	Target Neighborhood Hits	1023	Shared Neighborhood Hits	130
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MIA_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.069159 (rank : 276)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.069684 (rank : 275)
Query Neighborhood Hits	235	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MPP2_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.051582 (rank : 360)
Query Neighborhood Hits	235	Target Neighborhood Hits	173	Shared Neighborhood Hits	62
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.050161 (rank : 367)
Query Neighborhood Hits	235	Target Neighborhood Hits	189	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP5_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.055254 (rank : 344)
Query Neighborhood Hits	235	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.054236 (rank : 349)
Query Neighborhood Hits	235	Target Neighborhood Hits	226	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.070610 (rank : 273)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.068531 (rank : 280)
Query Neighborhood Hits	235	Target Neighborhood Hits	187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NEBL_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.201162 (rank : 169)
Query Neighborhood Hits	235	Target Neighborhood Hits	457	Shared Neighborhood Hits	144
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.205794 (rank : 163)
Query Neighborhood Hits	235	Target Neighborhood Hits	114	Shared Neighborhood Hits	92
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

P55G_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.076438 (rank : 264)
Query Neighborhood Hits	235	Target Neighborhood Hits	451	Shared Neighborhood Hits	50
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.074156 (rank : 269)
Query Neighborhood Hits	235	Target Neighborhood Hits	401	Shared Neighborhood Hits	46
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.106666 (rank : 214)
Query Neighborhood Hits	235	Target Neighborhood Hits	479	Shared Neighborhood Hits	92
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.107736 (rank : 212)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	97
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.093568 (rank : 226)
Query Neighborhood Hits	235	Target Neighborhood Hits	543	Shared Neighborhood Hits	67
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.090256 (rank : 235)
Query Neighborhood Hits	235	Target Neighborhood Hits	519	Shared Neighborhood Hits	67
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHA6_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.055445 (rank : 341)
Query Neighborhood Hits	235	Target Neighborhood Hits	556	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.054110 (rank : 350)
Query Neighborhood Hits	235	Target Neighborhood Hits	591	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.145997 (rank : 195)
Query Neighborhood Hits	235	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.143585 (rank : 196)
Query Neighborhood Hits	235	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.155299 (rank : 187)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.154629 (rank : 189)
Query Neighborhood Hits	235	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.205001 (rank : 166)
Query Neighborhood Hits	235	Target Neighborhood Hits	293	Shared Neighborhood Hits	131
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.211857 (rank : 158)
Query Neighborhood Hits	235	Target Neighborhood Hits	314	Shared Neighborhood Hits	136
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.200239 (rank : 170)
Query Neighborhood Hits	235	Target Neighborhood Hits	280	Shared Neighborhood Hits	127
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

RASA1_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.068853 (rank : 278)
Query Neighborhood Hits	235	Target Neighborhood Hits	258	Shared Neighborhood Hits	54
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RBNS5_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.067528 (rank : 285)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.062688 (rank : 302)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.055972 (rank : 337)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.060486 (rank : 312)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.066201 (rank : 288)
Query Neighborhood Hits	235	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.065161 (rank : 293)
Query Neighborhood Hits	235	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGL1_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.056101 (rank : 335)
Query Neighborhood Hits	235	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.052326 (rank : 356)
Query Neighborhood Hits	235	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RHG09_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.062777 (rank : 300)
Query Neighborhood Hits	235	Target Neighborhood Hits	186	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.060218 (rank : 313)
Query Neighborhood Hits	235	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.059087 (rank : 321)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG26_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.149829 (rank : 193)
Query Neighborhood Hits	235	Target Neighborhood Hits	281	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.173440 (rank : 178)
Query Neighborhood Hits	235	Target Neighborhood Hits	263	Shared Neighborhood Hits	104
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.168594 (rank : 182)
Query Neighborhood Hits	235	Target Neighborhood Hits	246	Shared Neighborhood Hits	97
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RPGF1_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.063527 (rank : 299)
Query Neighborhood Hits	235	Target Neighborhood Hits	262	Shared Neighborhood Hits	14
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF2_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.055263 (rank : 343)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF4_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.050057 (rank : 368)
Query Neighborhood Hits	235	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF6_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.052211 (rank : 358)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RUFY1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.050594 (rank : 363)
Query Neighborhood Hits	235	Target Neighborhood Hits	848	Shared Neighborhood Hits	33
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.052618 (rank : 355)
Query Neighborhood Hits	235	Target Neighborhood Hits	1208	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.050816 (rank : 361)
Query Neighborhood Hits	235	Target Neighborhood Hits	820	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SAMN1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.059481 (rank : 319)
Query Neighborhood Hits	235	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.057001 (rank : 329)
Query Neighborhood Hits	235	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.062740 (rank : 301)
Query Neighborhood Hits	235	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.057602 (rank : 327)
Query Neighborhood Hits	235	Target Neighborhood Hits	263	Shared Neighborhood Hits	51
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SHB_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.068053 (rank : 282)
Query Neighborhood Hits	235	Target Neighborhood Hits	141	Shared Neighborhood Hits	37
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.071755 (rank : 271)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	36
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.060580 (rank : 311)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.059925 (rank : 315)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	38
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.062278 (rank : 304)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.063906 (rank : 298)
Query Neighborhood Hits	235	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.061021 (rank : 309)
Query Neighborhood Hits	235	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.071974 (rank : 270)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	37
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.060682 (rank : 310)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.068738 (rank : 279)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	36
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.069124 (rank : 277)
Query Neighborhood Hits	235	Target Neighborhood Hits	164	Shared Neighborhood Hits	36
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.071176 (rank : 272)
Query Neighborhood Hits	235	Target Neighborhood Hits	169	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.123608 (rank : 201)
Query Neighborhood Hits	235	Target Neighborhood Hits	96	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.121384 (rank : 203)
Query Neighborhood Hits	235	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.118138 (rank : 206)
Query Neighborhood Hits	235	Target Neighborhood Hits	86	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.119389 (rank : 205)
Query Neighborhood Hits	235	Target Neighborhood Hits	88	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.065772 (rank : 290)
Query Neighborhood Hits	235	Target Neighborhood Hits	113	Shared Neighborhood Hits	34
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.064053 (rank : 297)
Query Neighborhood Hits	235	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.085557 (rank : 244)
Query Neighborhood Hits	235	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.084779 (rank : 246)
Query Neighborhood Hits	235	Target Neighborhood Hits	136	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.078821 (rank : 255)
Query Neighborhood Hits	235	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.085278 (rank : 245)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.155824 (rank : 186)
Query Neighborhood Hits	235	Target Neighborhood Hits	207	Shared Neighborhood Hits	105
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.160072 (rank : 185)
Query Neighborhood Hits	235	Target Neighborhood Hits	198	Shared Neighborhood Hits	104
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.109360 (rank : 210)
Query Neighborhood Hits	235	Target Neighborhood Hits	148	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.087547 (rank : 239)
Query Neighborhood Hits	235	Target Neighborhood Hits	141	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.090408 (rank : 233)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTB2_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.050343 (rank : 365)
Query Neighborhood Hits	235	Target Neighborhood Hits	748	Shared Neighborhood Hits	34
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.050215 (rank : 366)
Query Neighborhood Hits	235	Target Neighborhood Hits	770	Shared Neighborhood Hits	37
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SRC_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.076122 (rank : 267)
Query Neighborhood Hits	235	Target Neighborhood Hits	1033	Shared Neighborhood Hits	132
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

STS1_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.064388 (rank : 295)
Query Neighborhood Hits	235	Target Neighborhood Hits	106	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.064341 (rank : 296)
Query Neighborhood Hits	235	Target Neighborhood Hits	104	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.091610 (rank : 231)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TEC_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.061930 (rank : 306)
Query Neighborhood Hits	235	Target Neighborhood Hits	1006	Shared Neighborhood Hits	118
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.054373 (rank : 348)
Query Neighborhood Hits	235	Target Neighborhood Hits	971	Shared Neighborhood Hits	101
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.058922 (rank : 324)
Query Neighborhood Hits	235	Target Neighborhood Hits	980	Shared Neighborhood Hits	111
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ZFY16_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.079060 (rank : 253)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.081437 (rank : 248)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.054637 (rank : 347)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	11
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.052256 (rank : 357)
Query Neighborhood Hits	235	Target Neighborhood Hits	143	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.076408 (rank : 266)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.078562 (rank : 256)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.087314 (rank : 240)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.085659 (rank : 243)
Query Neighborhood Hits	235	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ARHG9_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	235
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.999559 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	235	Target Neighborhood Hits	234	Shared Neighborhood Hits	231
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG4_HUMAN
NC score	0.977972 (rank : 3)	θ value	6.99473e-178 (rank : 3)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	211
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
NC score	0.976515 (rank : 4)	θ value	1.46188e-167 (rank : 4)
Query Neighborhood Hits	235	Target Neighborhood Hits	185	Shared Neighborhood Hits	168
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PREX1_HUMAN
NC score	0.820045 (rank : 5)	θ value	7.75577e-52 (rank : 5)
Query Neighborhood Hits	235	Target Neighborhood Hits	177	Shared Neighborhood Hits	74
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
NC score	0.807039 (rank : 6)	θ value	1.6813e-30 (rank : 6)
Query Neighborhood Hits	235	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG7_HUMAN
NC score	0.771175 (rank : 7)	θ value	6.84181e-24 (rank : 9)
Query Neighborhood Hits	235	Target Neighborhood Hits	347	Shared Neighborhood Hits	207
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.767417 (rank : 8)	θ value	1.5242e-23 (rank : 10)
Query Neighborhood Hits	235	Target Neighborhood Hits	396	Shared Neighborhood Hits	208
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

TIAM1_MOUSE
NC score	0.733611 (rank : 9)	θ value	2.51237e-26 (rank : 7)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.726841 (rank : 10)	θ value	4.73814e-25 (rank : 8)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG6_HUMAN
NC score	0.719311 (rank : 11)	θ value	9.56915e-18 (rank : 21)
Query Neighborhood Hits	235	Target Neighborhood Hits	376	Shared Neighborhood Hits	189
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

MCF2_HUMAN
NC score	0.717708 (rank : 12)	θ value	2.69047e-20 (rank : 16)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

DNMBP_MOUSE
NC score	0.711190 (rank : 13)	θ value	1.99529e-15 (rank : 30)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	205
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_MOUSE
NC score	0.704406 (rank : 14)	θ value	3.63628e-17 (rank : 23)
Query Neighborhood Hits	235	Target Neighborhood Hits	394	Shared Neighborhood Hits	189
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DNMBP_HUMAN
NC score	0.702463 (rank : 15)	θ value	5.25075e-16 (rank : 28)
Query Neighborhood Hits	235	Target Neighborhood Hits	413	Shared Neighborhood Hits	207
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MCF2L_MOUSE
NC score	0.691921 (rank : 16)	θ value	8.95645e-16 (rank : 29)
Query Neighborhood Hits	235	Target Neighborhood Hits	255	Shared Neighborhood Hits	91
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG3_HUMAN
NC score	0.683726 (rank : 17)	θ value	2.60593e-15 (rank : 33)
Query Neighborhood Hits	235	Target Neighborhood Hits	82	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.682891 (rank : 18)	θ value	3.40345e-15 (rank : 34)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	65
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

VAV_MOUSE
NC score	0.675110 (rank : 19)	θ value	1.74391e-19 (rank : 19)
Query Neighborhood Hits	235	Target Neighborhood Hits	430	Shared Neighborhood Hits	200
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG8_HUMAN
NC score	0.673195 (rank : 20)	θ value	6.41864e-14 (rank : 42)
Query Neighborhood Hits	235	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

VAV2_MOUSE
NC score	0.670274 (rank : 21)	θ value	1.42661e-21 (rank : 14)
Query Neighborhood Hits	235	Target Neighborhood Hits	456	Shared Neighborhood Hits	190
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ECT2_MOUSE
NC score	0.669349 (rank : 22)	θ value	3.89403e-11 (rank : 49)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV2_HUMAN
NC score	0.666292 (rank : 23)	θ value	9.24701e-21 (rank : 15)
Query Neighborhood Hits	235	Target Neighborhood Hits	453	Shared Neighborhood Hits	190
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
NC score	0.665182 (rank : 24)	θ value	5.99374e-20 (rank : 18)
Query Neighborhood Hits	235	Target Neighborhood Hits	452	Shared Neighborhood Hits	197
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG8_MOUSE
NC score	0.661814 (rank : 25)	θ value	2.88119e-14 (rank : 40)
Query Neighborhood Hits	235	Target Neighborhood Hits	79	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ECT2_HUMAN
NC score	0.657339 (rank : 26)	θ value	2.52405e-10 (rank : 53)
Query Neighborhood Hits	235	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_MOUSE
NC score	0.653057 (rank : 27)	θ value	2.69671e-12 (rank : 48)
Query Neighborhood Hits	235	Target Neighborhood Hits	257	Shared Neighborhood Hits	71
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

VAV3_MOUSE
NC score	0.651451 (rank : 28)	θ value	6.62687e-19 (rank : 20)
Query Neighborhood Hits	235	Target Neighborhood Hits	404	Shared Neighborhood Hits	189
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.649079 (rank : 29)	θ value	1.24977e-17 (rank : 22)
Query Neighborhood Hits	235	Target Neighborhood Hits	398	Shared Neighborhood Hits	190
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FGD4_HUMAN
NC score	0.634380 (rank : 30)	θ value	8.10077e-17 (rank : 25)
Query Neighborhood Hits	235	Target Neighborhood Hits	219	Shared Neighborhood Hits	73
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.632271 (rank : 31)	θ value	3.40345e-15 (rank : 35)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	75
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD3_HUMAN
NC score	0.628600 (rank : 32)	θ value	1.47974e-10 (rank : 52)
Query Neighborhood Hits	235	Target Neighborhood Hits	249	Shared Neighborhood Hits	70
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
NC score	0.622880 (rank : 33)	θ value	7.09661e-13 (rank : 44)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	73
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHGG_HUMAN
NC score	0.619212 (rank : 34)	θ value	3.29651e-10 (rank : 56)
Query Neighborhood Hits	235	Target Neighborhood Hits	129	Shared Neighborhood Hits	90
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
NC score	0.616698 (rank : 35)	θ value	6.21693e-09 (rank : 58)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	100
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD2_MOUSE
NC score	0.610530 (rank : 36)	θ value	1.58096e-12 (rank : 45)
Query Neighborhood Hits	235	Target Neighborhood Hits	163	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

NGEF_HUMAN
NC score	0.606635 (rank : 37)	θ value	9.92553e-07 (rank : 66)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	117
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGA_MOUSE
NC score	0.605699 (rank : 38)	θ value	2.69671e-12 (rank : 47)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	62
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG5_HUMAN
NC score	0.600638 (rank : 39)	θ value	3.19293e-05 (rank : 86)
Query Neighborhood Hits	235	Target Neighborhood Hits	172	Shared Neighborhood Hits	121
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_HUMAN
NC score	0.598217 (rank : 40)	θ value	3.29651e-10 (rank : 55)
Query Neighborhood Hits	235	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD1_HUMAN
NC score	0.592309 (rank : 41)	θ value	1.86753e-13 (rank : 43)
Query Neighborhood Hits	235	Target Neighborhood Hits	367	Shared Neighborhood Hits	79
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.591321 (rank : 42)	θ value	4.91457e-14 (rank : 41)
Query Neighborhood Hits	235	Target Neighborhood Hits	387	Shared Neighborhood Hits	75
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

NGEF_MOUSE
NC score	0.590019 (rank : 43)	θ value	4.92598e-06 (rank : 72)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	118
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ITSN2_HUMAN
NC score	0.589344 (rank : 44)	θ value	6.40375e-22 (rank : 12)
Query Neighborhood Hits	235	Target Neighborhood Hits	1173	Shared Neighborhood Hits	217
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

HAPIP_HUMAN
NC score	0.572427 (rank : 45)	θ value	1.29331e-14 (rank : 37)
Query Neighborhood Hits	235	Target Neighborhood Hits	350	Shared Neighborhood Hits	77
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN2_MOUSE
NC score	0.555760 (rank : 46)	θ value	5.99374e-20 (rank : 17)
Query Neighborhood Hits	235	Target Neighborhood Hits	1371	Shared Neighborhood Hits	216
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHGB_HUMAN
NC score	0.553191 (rank : 47)	θ value	2.0648e-12 (rank : 46)
Query Neighborhood Hits	235	Target Neighborhood Hits	375	Shared Neighborhood Hits	79
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ITSN1_HUMAN
NC score	0.548687 (rank : 48)	θ value	2.87452e-22 (rank : 11)
Query Neighborhood Hits	235	Target Neighborhood Hits	1757	Shared Neighborhood Hits	220
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.548034 (rank : 49)	θ value	8.36355e-22 (rank : 13)
Query Neighborhood Hits	235	Target Neighborhood Hits	1669	Shared Neighborhood Hits	219
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG1_HUMAN
NC score	0.543824 (rank : 50)	θ value	5.26297e-08 (rank : 60)
Query Neighborhood Hits	235	Target Neighborhood Hits	176	Shared Neighborhood Hits	61
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

PKHG4_HUMAN
NC score	0.541783 (rank : 51)	θ value	4.92598e-06 (rank : 73)
Query Neighborhood Hits	235	Target Neighborhood Hits	200	Shared Neighborhood Hits	60
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHGC_HUMAN
NC score	0.527936 (rank : 52)	θ value	5.08577e-11 (rank : 50)
Query Neighborhood Hits	235	Target Neighborhood Hits	351	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_MOUSE
NC score	0.521959 (rank : 53)	θ value	1.69304e-06 (rank : 69)
Query Neighborhood Hits	235	Target Neighborhood Hits	120	Shared Neighborhood Hits	64
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGC_MOUSE
NC score	0.519901 (rank : 54)	θ value	4.30538e-10 (rank : 57)
Query Neighborhood Hits	235	Target Neighborhood Hits	344	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
NC score	0.516650 (rank : 55)	θ value	2.44474e-05 (rank : 84)
Query Neighborhood Hits	235	Target Neighborhood Hits	214	Shared Neighborhood Hits	66
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FGD6_MOUSE
NC score	0.514669 (rank : 56)	θ value	1.17247e-07 (rank : 62)
Query Neighborhood Hits	235	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.511693 (rank : 57)	θ value	6.21693e-09 (rank : 59)
Query Neighborhood Hits	235	Target Neighborhood Hits	237	Shared Neighborhood Hits	68
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

LBC_HUMAN
NC score	0.506256 (rank : 58)	θ value	1.43324e-05 (rank : 82)
Query Neighborhood Hits	235	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_HUMAN
NC score	0.487747 (rank : 59)	θ value	0.00228821 (rank : 106)
Query Neighborhood Hits	235	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

FARP2_MOUSE
NC score	0.482878 (rank : 60)	θ value	6.20254e-17 (rank : 24)
Query Neighborhood Hits	235	Target Neighborhood Hits	209	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_MOUSE
NC score	0.474302 (rank : 61)	θ value	6.43352e-06 (rank : 75)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	62
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RGNEF_MOUSE
NC score	0.463601 (rank : 62)	θ value	2.52405e-10 (rank : 54)
Query Neighborhood Hits	235	Target Neighborhood Hits	641	Shared Neighborhood Hits	76
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FARP2_HUMAN
NC score	0.463146 (rank : 63)	θ value	3.07829e-16 (rank : 26)
Query Neighborhood Hits	235	Target Neighborhood Hits	240	Shared Neighborhood Hits	69
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG1_MOUSE
NC score	0.457580 (rank : 64)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

SH3K1_HUMAN
NC score	0.430790 (rank : 65)	θ value	0.00102713 (rank : 101)
Query Neighborhood Hits	235	Target Neighborhood Hits	341	Shared Neighborhood Hits	154
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_HUMAN
NC score	0.427349 (rank : 66)	θ value	3.77169e-06 (rank : 71)
Query Neighborhood Hits	235	Target Neighborhood Hits	198	Shared Neighborhood Hits	146
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3K1_MOUSE
NC score	0.420263 (rank : 67)	θ value	0.00102713 (rank : 102)
Query Neighborhood Hits	235	Target Neighborhood Hits	332	Shared Neighborhood Hits	156
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
NC score	0.420182 (rank : 68)	θ value	9.29e-05 (rank : 90)
Query Neighborhood Hits	235	Target Neighborhood Hits	315	Shared Neighborhood Hits	156
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

FARP1_HUMAN
NC score	0.418484 (rank : 69)	θ value	1.99529e-15 (rank : 31)
Query Neighborhood Hits	235	Target Neighborhood Hits	241	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

STAC_HUMAN
NC score	0.417869 (rank : 70)	θ value	3.41135e-07 (rank : 63)
Query Neighborhood Hits	235	Target Neighborhood Hits	276	Shared Neighborhood Hits	152
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CD2AP_MOUSE
NC score	0.415611 (rank : 71)	θ value	0.00390308 (rank : 110)
Query Neighborhood Hits	235	Target Neighborhood Hits	336	Shared Neighborhood Hits	159
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

NCF4_MOUSE
NC score	0.415236 (rank : 72)	θ value	1.09739e-05 (rank : 80)
Query Neighborhood Hits	235	Target Neighborhood Hits	177	Shared Neighborhood Hits	133
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_HUMAN
NC score	0.411886 (rank : 73)	θ value	1.43324e-05 (rank : 83)
Query Neighborhood Hits	235	Target Neighborhood Hits	161	Shared Neighborhood Hits	123
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_MOUSE
NC score	0.406971 (rank : 74)	θ value	9.92553e-07 (rank : 67)
Query Neighborhood Hits	235	Target Neighborhood Hits	268	Shared Neighborhood Hits	152
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF1_MOUSE
NC score	0.406087 (rank : 75)	θ value	7.1131e-05 (rank : 89)
Query Neighborhood Hits	235	Target Neighborhood Hits	198	Shared Neighborhood Hits	145
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

GNRP_HUMAN
NC score	0.400491 (rank : 76)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	235	Target Neighborhood Hits	239	Shared Neighborhood Hits	59
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
NC score	0.394799 (rank : 77)	θ value	8.97725e-08 (rank : 61)
Query Neighborhood Hits	235	Target Neighborhood Hits	166	Shared Neighborhood Hits	69
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

NCF2_HUMAN
NC score	0.391135 (rank : 78)	θ value	0.0961366 (rank : 147)
Query Neighborhood Hits	235	Target Neighborhood Hits	229	Shared Neighborhood Hits	146
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

BCR_HUMAN
NC score	0.389910 (rank : 79)	θ value	8.40245e-06 (rank : 76)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	68
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SOS1_HUMAN
NC score	0.389594 (rank : 80)	θ value	2.20605e-14 (rank : 38)
Query Neighborhood Hits	235	Target Neighborhood Hits	274	Shared Neighborhood Hits	40
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

STAM1_HUMAN
NC score	0.382655 (rank : 81)	θ value	4.92598e-06 (rank : 74)
Query Neighborhood Hits	235	Target Neighborhood Hits	271	Shared Neighborhood Hits	163
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.381556 (rank : 82)	θ value	2.88788e-06 (rank : 70)
Query Neighborhood Hits	235	Target Neighborhood Hits	273	Shared Neighborhood Hits	161
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

FGD5_HUMAN
NC score	0.379192 (rank : 83)	θ value	8.40245e-06 (rank : 77)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

SOS1_MOUSE
NC score	0.378399 (rank : 84)	θ value	2.20605e-14 (rank : 39)
Query Neighborhood Hits	235	Target Neighborhood Hits	281	Shared Neighborhood Hits	39
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

GRAP2_MOUSE
NC score	0.375804 (rank : 85)	θ value	5.81887e-07 (rank : 64)
Query Neighborhood Hits	235	Target Neighborhood Hits	297	Shared Neighborhood Hits	162
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.373322 (rank : 86)	θ value	9.92553e-07 (rank : 65)
Query Neighborhood Hits	235	Target Neighborhood Hits	304	Shared Neighborhood Hits	162
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

STAC3_MOUSE
NC score	0.369829 (rank : 87)	θ value	0.000786445 (rank : 98)
Query Neighborhood Hits	235	Target Neighborhood Hits	232	Shared Neighborhood Hits	132
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM2_MOUSE
NC score	0.367717 (rank : 88)	θ value	9.29e-05 (rank : 91)
Query Neighborhood Hits	235	Target Neighborhood Hits	285	Shared Neighborhood Hits	159
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAC3_HUMAN
NC score	0.367476 (rank : 89)	θ value	0.000786445 (rank : 97)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	132
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SOS2_HUMAN
NC score	0.365234 (rank : 90)	θ value	7.58209e-15 (rank : 36)
Query Neighborhood Hits	235	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

HCLS1_HUMAN
NC score	0.364947 (rank : 91)	θ value	0.00175202 (rank : 104)
Query Neighborhood Hits	235	Target Neighborhood Hits	358	Shared Neighborhood Hits	147
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
NC score	0.363462 (rank : 92)	θ value	0.000786445 (rank : 94)
Query Neighborhood Hits	235	Target Neighborhood Hits	329	Shared Neighborhood Hits	143
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAM2_HUMAN
NC score	0.361965 (rank : 93)	θ value	5.44631e-05 (rank : 88)
Query Neighborhood Hits	235	Target Neighborhood Hits	288	Shared Neighborhood Hits	159
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

GRAP_HUMAN
NC score	0.360543 (rank : 94)	θ value	0.00175202 (rank : 103)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRB2_HUMAN
NC score	0.359193 (rank : 95)	θ value	0.00102713 (rank : 99)
Query Neighborhood Hits	235	Target Neighborhood Hits	310	Shared Neighborhood Hits	162
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.359061 (rank : 96)	θ value	0.00102713 (rank : 100)
Query Neighborhood Hits	235	Target Neighborhood Hits	312	Shared Neighborhood Hits	162
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP_MOUSE
NC score	0.357455 (rank : 97)	θ value	0.0113563 (rank : 120)
Query Neighborhood Hits	235	Target Neighborhood Hits	309	Shared Neighborhood Hits	165
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SRC8_HUMAN
NC score	0.348634 (rank : 98)	θ value	0.0431538 (rank : 136)
Query Neighborhood Hits	235	Target Neighborhood Hits	269	Shared Neighborhood Hits	144
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

VINEX_MOUSE
NC score	0.346069 (rank : 99)	θ value	1.38821 (rank : 190)
Query Neighborhood Hits	235	Target Neighborhood Hits	286	Shared Neighborhood Hits	156
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRC8_MOUSE
NC score	0.345936 (rank : 100)	θ value	0.0252991 (rank : 134)
Query Neighborhood Hits	235	Target Neighborhood Hits	292	Shared Neighborhood Hits	146
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRBS1_HUMAN
NC score	0.343783 (rank : 101)	θ value	0.62314 (rank : 169)
Query Neighborhood Hits	235	Target Neighborhood Hits	396	Shared Neighborhood Hits	155
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.343408 (rank : 102)	θ value	2.36792 (rank : 205)
Query Neighborhood Hits	235	Target Neighborhood Hits	270	Shared Neighborhood Hits	151
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3G3_MOUSE
NC score	0.341181 (rank : 103)	θ value	0.0252991 (rank : 133)
Query Neighborhood Hits	235	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_MOUSE
NC score	0.340671 (rank : 104)	θ value	1.81305 (rank : 198)
Query Neighborhood Hits	235	Target Neighborhood Hits	409	Shared Neighborhood Hits	153
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCK1_HUMAN
NC score	0.340482 (rank : 105)	θ value	0.279714 (rank : 156)
Query Neighborhood Hits	235	Target Neighborhood Hits	312	Shared Neighborhood Hits	162
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3G3_HUMAN
NC score	0.337846 (rank : 106)	θ value	0.0113563 (rank : 122)
Query Neighborhood Hits	235	Target Neighborhood Hits	222	Shared Neighborhood Hits	146
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

FGD5_MOUSE
NC score	0.337843 (rank : 107)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

SH3G2_HUMAN
NC score	0.335916 (rank : 108)	θ value	0.0193708 (rank : 129)
Query Neighborhood Hits	235	Target Neighborhood Hits	324	Shared Neighborhood Hits	155
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_HUMAN
NC score	0.334659 (rank : 109)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	147
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
NC score	0.333973 (rank : 110)	θ value	0.00390308 (rank : 111)
Query Neighborhood Hits	235	Target Neighborhood Hits	291	Shared Neighborhood Hits	150
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
NC score	0.331576 (rank : 111)	θ value	0.00665767 (rank : 114)
Query Neighborhood Hits	235	Target Neighborhood Hits	319	Shared Neighborhood Hits	154
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

NCK2_HUMAN
NC score	0.328941 (rank : 112)	θ value	0.0961366 (rank : 148)
Query Neighborhood Hits	235	Target Neighborhood Hits	310	Shared Neighborhood Hits	152
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ABI2_MOUSE
NC score	0.313299 (rank : 113)	θ value	0.47712 (rank : 160)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	156
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.311619 (rank : 114)	θ value	0.47712 (rank : 159)
Query Neighborhood Hits	235	Target Neighborhood Hits	350	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI1_MOUSE
NC score	0.303223 (rank : 115)	θ value	0.279714 (rank : 154)
Query Neighborhood Hits	235	Target Neighborhood Hits	246	Shared Neighborhood Hits	155
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PPIP1_HUMAN
NC score	0.298938 (rank : 116)	θ value	0.47712 (rank : 163)
Query Neighborhood Hits	235	Target Neighborhood Hits	389	Shared Neighborhood Hits	159
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CRKL_HUMAN
NC score	0.298418 (rank : 117)	θ value	0.279714 (rank : 155)
Query Neighborhood Hits	235	Target Neighborhood Hits	313	Shared Neighborhood Hits	156
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

PPIP1_MOUSE
NC score	0.297585 (rank : 118)	θ value	0.365318 (rank : 158)
Query Neighborhood Hits	235	Target Neighborhood Hits	377	Shared Neighborhood Hits	159
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CRK_MOUSE
NC score	0.291297 (rank : 119)	θ value	3.0926 (rank : 209)
Query Neighborhood Hits	235	Target Neighborhood Hits	314	Shared Neighborhood Hits	158
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_MOUSE
NC score	0.290198 (rank : 120)	θ value	0.365318 (rank : 157)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	152
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

NPHP1_MOUSE
NC score	0.289626 (rank : 121)	θ value	0.00869519 (rank : 118)
Query Neighborhood Hits	235	Target Neighborhood Hits	267	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CRK_HUMAN
NC score	0.286121 (rank : 122)	θ value	3.0926 (rank : 208)
Query Neighborhood Hits	235	Target Neighborhood Hits	308	Shared Neighborhood Hits	157
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_HUMAN
NC score	0.285101 (rank : 123)	θ value	1.06291 (rank : 173)
Query Neighborhood Hits	235	Target Neighborhood Hits	257	Shared Neighborhood Hits	154
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

AHI1_HUMAN
NC score	0.281919 (rank : 124)	θ value	4.1701e-05 (rank : 87)
Query Neighborhood Hits	235	Target Neighborhood Hits	537	Shared Neighborhood Hits	156
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

OSTF1_HUMAN
NC score	0.278722 (rank : 125)	θ value	0.125558 (rank : 150)
Query Neighborhood Hits	235	Target Neighborhood Hits	466	Shared Neighborhood Hits	156
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DBNL_HUMAN
NC score	0.277338 (rank : 126)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	235	Target Neighborhood Hits	244	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

AHI1_MOUSE
NC score	0.275293 (rank : 127)	θ value	0.000158464 (rank : 92)
Query Neighborhood Hits	235	Target Neighborhood Hits	496	Shared Neighborhood Hits	159
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

OSTF1_MOUSE
NC score	0.274469 (rank : 128)	θ value	0.125558 (rank : 151)
Query Neighborhood Hits	235	Target Neighborhood Hits	467	Shared Neighborhood Hits	155
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
NC score	0.274170 (rank : 129)	θ value	0.0736092 (rank : 143)
Query Neighborhood Hits	235	Target Neighborhood Hits	339	Shared Neighborhood Hits	154
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.272156 (rank : 130)	θ value	0.0563607 (rank : 140)
Query Neighborhood Hits	235	Target Neighborhood Hits	382	Shared Neighborhood Hits	159
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DBNL_MOUSE
NC score	0.271722 (rank : 131)	θ value	0.813845 (rank : 171)
Query Neighborhood Hits	235	Target Neighborhood Hits	306	Shared Neighborhood Hits	126
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

BCAR1_MOUSE
NC score	0.269736 (rank : 132)	θ value	0.00390308 (rank : 109)
Query Neighborhood Hits	235	Target Neighborhood Hits	438	Shared Neighborhood Hits	144
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CT032_HUMAN
NC score	0.264634 (rank : 133)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	235	Target Neighborhood Hits	235	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

BCAR1_HUMAN
NC score	0.261421 (rank : 134)	θ value	0.00390308 (rank : 108)
Query Neighborhood Hits	235	Target Neighborhood Hits	554	Shared Neighborhood Hits	145
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PACN1_HUMAN
NC score	0.253764 (rank : 135)	θ value	1.06291 (rank : 175)
Query Neighborhood Hits	235	Target Neighborhood Hits	320	Shared Neighborhood Hits	157
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CASL_HUMAN
NC score	0.253291 (rank : 136)	θ value	0.0252991 (rank : 131)
Query Neighborhood Hits	235	Target Neighborhood Hits	259	Shared Neighborhood Hits	128
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PACN1_MOUSE
NC score	0.252768 (rank : 137)	θ value	1.06291 (rank : 176)
Query Neighborhood Hits	235	Target Neighborhood Hits	283	Shared Neighborhood Hits	155
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CASL_MOUSE
NC score	0.249397 (rank : 138)	θ value	0.0148317 (rank : 124)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	126
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

TRIO_HUMAN
NC score	0.246609 (rank : 139)	θ value	1.99529e-15 (rank : 32)
Query Neighborhood Hits	235	Target Neighborhood Hits	1580	Shared Neighborhood Hits	124
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ABI3_MOUSE
NC score	0.246552 (rank : 140)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_HUMAN
NC score	0.245115 (rank : 141)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	119
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

RHG04_HUMAN
NC score	0.240920 (rank : 142)	θ value	0.000786445 (rank : 95)
Query Neighborhood Hits	235	Target Neighborhood Hits	307	Shared Neighborhood Hits	143
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

DUET_HUMAN
NC score	0.239887 (rank : 143)	θ value	4.02038e-16 (rank : 27)
Query Neighborhood Hits	235	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

PACN3_MOUSE
NC score	0.237444 (rank : 144)	θ value	3.0926 (rank : 214)
Query Neighborhood Hits	235	Target Neighborhood Hits	380	Shared Neighborhood Hits	149
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.235082 (rank : 145)	θ value	3.0926 (rank : 213)
Query Neighborhood Hits	235	Target Neighborhood Hits	385	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ANM2_HUMAN
NC score	0.234731 (rank : 146)	θ value	0.00869519 (rank : 115)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	128
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ASPP1_HUMAN
NC score	0.227358 (rank : 147)	θ value	1.09739e-05 (rank : 79)
Query Neighborhood Hits	235	Target Neighborhood Hits	956	Shared Neighborhood Hits	140
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

EFS_MOUSE
NC score	0.227309 (rank : 148)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	235	Target Neighborhood Hits	389	Shared Neighborhood Hits	132
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

NPHP1_HUMAN
NC score	0.227103 (rank : 149)	θ value	3.0926 (rank : 212)
Query Neighborhood Hits	235	Target Neighborhood Hits	288	Shared Neighborhood Hits	131
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ASPP1_MOUSE
NC score	0.225194 (rank : 150)	θ value	2.44474e-05 (rank : 85)
Query Neighborhood Hits	235	Target Neighborhood Hits	1244	Shared Neighborhood Hits	145
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IASPP_HUMAN
NC score	0.224235 (rank : 151)	θ value	0.00228821 (rank : 107)
Query Neighborhood Hits	235	Target Neighborhood Hits	688	Shared Neighborhood Hits	139
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

EFS_HUMAN
NC score	0.223206 (rank : 152)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	235	Target Neighborhood Hits	348	Shared Neighborhood Hits	128
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ANM2_MOUSE
NC score	0.220929 (rank : 153)	θ value	0.0563607 (rank : 138)
Query Neighborhood Hits	235	Target Neighborhood Hits	175	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

LASP1_HUMAN
NC score	0.220633 (rank : 154)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	235	Target Neighborhood Hits	293	Shared Neighborhood Hits	134
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.217332 (rank : 155)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	235	Target Neighborhood Hits	297	Shared Neighborhood Hits	132
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PEX13_MOUSE
NC score	0.215361 (rank : 156)	θ value	1.06291 (rank : 177)
Query Neighborhood Hits	235	Target Neighborhood Hits	126	Shared Neighborhood Hits	96
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

IASPP_MOUSE
NC score	0.212943 (rank : 157)	θ value	0.00175202 (rank : 105)
Query Neighborhood Hits	235	Target Neighborhood Hits	1024	Shared Neighborhood Hits	144
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PLCG1_MOUSE
NC score	0.211857 (rank : 158)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	235	Target Neighborhood Hits	314	Shared Neighborhood Hits	136
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SPTA2_HUMAN
NC score	0.210293 (rank : 159)	θ value	1.29631e-06 (rank : 68)
Query Neighborhood Hits	235	Target Neighborhood Hits	888	Shared Neighborhood Hits	166
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PEX13_HUMAN
NC score	0.208285 (rank : 160)	θ value	4.03905 (rank : 218)
Query Neighborhood Hits	235	Target Neighborhood Hits	128	Shared Neighborhood Hits	96
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

TCGAP_MOUSE
NC score	0.206764 (rank : 161)	θ value	0.00390308 (rank : 112)
Query Neighborhood Hits	235	Target Neighborhood Hits	409	Shared Neighborhood Hits	123
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NOXO1_HUMAN
NC score	0.205901 (rank : 162)	θ value	0.813845 (rank : 172)
Query Neighborhood Hits	235	Target Neighborhood Hits	100	Shared Neighborhood Hits	79
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
NC score	0.205794 (rank : 163)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	235	Target Neighborhood Hits	114	Shared Neighborhood Hits	92
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SRGP2_MOUSE
NC score	0.205564 (rank : 164)	θ value	0.0193708 (rank : 130)
Query Neighborhood Hits	235	Target Neighborhood Hits	324	Shared Neighborhood Hits	137
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SPTA1_MOUSE
NC score	0.205200 (rank : 165)	θ value	1.09739e-05 (rank : 81)
Query Neighborhood Hits	235	Target Neighborhood Hits	675	Shared Neighborhood Hits	139
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PLCG1_HUMAN
NC score	0.205001 (rank : 166)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	235	Target Neighborhood Hits	293	Shared Neighborhood Hits	131
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRGP1_HUMAN
NC score	0.201769 (rank : 167)	θ value	0.0113563 (rank : 123)
Query Neighborhood Hits	235	Target Neighborhood Hits	390	Shared Neighborhood Hits	132
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
NC score	0.201562 (rank : 168)	θ value	0.0431538 (rank : 137)
Query Neighborhood Hits	235	Target Neighborhood Hits	331	Shared Neighborhood Hits	135
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

NEBL_HUMAN
NC score	0.201162 (rank : 169)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	235	Target Neighborhood Hits	457	Shared Neighborhood Hits	144
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PLCG2_HUMAN
NC score	0.200239 (rank : 170)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	235	Target Neighborhood Hits	280	Shared Neighborhood Hits	127
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SPTA1_HUMAN
NC score	0.200104 (rank : 171)	θ value	8.40245e-06 (rank : 78)
Query Neighborhood Hits	235	Target Neighborhood Hits	748	Shared Neighborhood Hits	149
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

FNBP2_HUMAN
NC score	0.195340 (rank : 172)	θ value	0.0148317 (rank : 125)
Query Neighborhood Hits	235	Target Neighborhood Hits	432	Shared Neighborhood Hits	130
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

BI2L1_HUMAN
NC score	0.192538 (rank : 173)	θ value	0.00869519 (rank : 116)
Query Neighborhood Hits	235	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TCGAP_HUMAN
NC score	0.187507 (rank : 174)	θ value	0.00509761 (rank : 113)
Query Neighborhood Hits	235	Target Neighborhood Hits	872	Shared Neighborhood Hits	129
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NEBU_HUMAN
NC score	0.184678 (rank : 175)	θ value	4.03905 (rank : 217)
Query Neighborhood Hits	235	Target Neighborhood Hits	420	Shared Neighborhood Hits	142
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ASPP2_HUMAN
NC score	0.183879 (rank : 176)	θ value	0.000158464 (rank : 93)
Query Neighborhood Hits	235	Target Neighborhood Hits	1156	Shared Neighborhood Hits	135
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SHAN2_MOUSE
NC score	0.182223 (rank : 177)	θ value	0.62314 (rank : 168)
Query Neighborhood Hits	235	Target Neighborhood Hits	446	Shared Neighborhood Hits	107
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

RIMB2_HUMAN
NC score	0.173440 (rank : 178)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	235	Target Neighborhood Hits	263	Shared Neighborhood Hits	104
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

DDEF2_MOUSE
NC score	0.171144 (rank : 179)	θ value	0.0113563 (rank : 119)
Query Neighborhood Hits	235	Target Neighborhood Hits	625	Shared Neighborhood Hits	134
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
NC score	0.170283 (rank : 180)	θ value	0.0961366 (rank : 145)
Query Neighborhood Hits	235	Target Neighborhood Hits	592	Shared Neighborhood Hits	126
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RUSC1_HUMAN
NC score	0.168837 (rank : 181)	θ value	0.62314 (rank : 167)
Query Neighborhood Hits	235	Target Neighborhood Hits	226	Shared Neighborhood Hits	116
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RIMB2_MOUSE
NC score	0.168594 (rank : 182)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	235	Target Neighborhood Hits	246	Shared Neighborhood Hits	97
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

DDEF2_HUMAN
NC score	0.168151 (rank : 183)	θ value	0.0252991 (rank : 132)
Query Neighborhood Hits	235	Target Neighborhood Hits	599	Shared Neighborhood Hits	135
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RUSC1_MOUSE
NC score	0.163956 (rank : 184)	θ value	1.06291 (rank : 178)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SNX18_MOUSE
NC score	0.160072 (rank : 185)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	235	Target Neighborhood Hits	198	Shared Neighborhood Hits	104
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.155824 (rank : 186)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	235	Target Neighborhood Hits	207	Shared Neighborhood Hits	105
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PKHF2_HUMAN
NC score	0.155299 (rank : 187)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	235	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

MYO1F_MOUSE
NC score	0.154845 (rank : 188)	θ value	0.00869519 (rank : 117)
Query Neighborhood Hits	235	Target Neighborhood Hits	262	Shared Neighborhood Hits	149
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PKHF2_MOUSE
NC score	0.154629 (rank : 189)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	235	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

BI2L1_MOUSE
NC score	0.154139 (rank : 190)	θ value	0.125558 (rank : 149)
Query Neighborhood Hits	235	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

MYO1F_HUMAN
NC score	0.153076 (rank : 191)	θ value	0.0148317 (rank : 127)
Query Neighborhood Hits	235	Target Neighborhood Hits	275	Shared Neighborhood Hits	149
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SHAN1_HUMAN
NC score	0.149857 (rank : 192)	θ value	0.0148317 (rank : 128)
Query Neighborhood Hits	235	Target Neighborhood Hits	1041	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

RHG26_HUMAN
NC score	0.149829 (rank : 193)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	235	Target Neighborhood Hits	281	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

MYO1E_HUMAN
NC score	0.149677 (rank : 194)	θ value	0.0736092 (rank : 142)
Query Neighborhood Hits	235	Target Neighborhood Hits	293	Shared Neighborhood Hits	149
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PKHF1_HUMAN
NC score	0.145997 (rank : 195)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	235	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.143585 (rank : 196)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	235	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ES8L3_MOUSE
NC score	0.136982 (rank : 197)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	235	Target Neighborhood Hits	168	Shared Neighborhood Hits	112
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

BAIP2_MOUSE
NC score	0.133188 (rank : 198)	θ value	0.47712 (rank : 162)
Query Neighborhood Hits	235	Target Neighborhood Hits	185	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.131164 (rank : 199)	θ value	0.47712 (rank : 161)
Query Neighborhood Hits	235	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ES8L3_HUMAN
NC score	0.125898 (rank : 200)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SHLB1_HUMAN
NC score	0.123608 (rank : 201)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	235	Target Neighborhood Hits	96	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

OBSCN_HUMAN
NC score	0.122536 (rank : 202)	θ value	8.67504e-11 (rank : 51)
Query Neighborhood Hits	235	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SHLB1_MOUSE
NC score	0.121384 (rank : 203)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	235	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SPN90_HUMAN
NC score	0.119509 (rank : 204)	θ value	5.27518 (rank : 225)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SHLB2_MOUSE
NC score	0.119389 (rank : 205)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	235	Target Neighborhood Hits	88	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.118138 (rank : 206)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	235	Target Neighborhood Hits	86	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ES8L2_HUMAN
NC score	0.113636 (rank : 207)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	235	Target Neighborhood Hits	193	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_MOUSE
NC score	0.113224 (rank : 208)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	101
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_MOUSE
NC score	0.109862 (rank : 209)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	235	Target Neighborhood Hits	169	Shared Neighborhood Hits	98
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SNX9_HUMAN
NC score	0.109360 (rank : 210)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	235	Target Neighborhood Hits	148	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

RIMB1_HUMAN
NC score	0.108431 (rank : 211)	θ value	1.81305 (rank : 197)
Query Neighborhood Hits	235	Target Neighborhood Hits	1479	Shared Neighborhood Hits	129
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

P85A_MOUSE
NC score	0.107736 (rank : 212)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	235	Target Neighborhood Hits	435	Shared Neighborhood Hits	97
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

EPS8_HUMAN
NC score	0.107603 (rank : 213)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	90
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

P85A_HUMAN
NC score	0.106666 (rank : 214)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	235	Target Neighborhood Hits	479	Shared Neighborhood Hits	92
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ES8L1_MOUSE
NC score	0.102979 (rank : 215)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	235	Target Neighborhood Hits	143	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

RIMB1_MOUSE
NC score	0.102936 (rank : 216)	θ value	0.62314 (rank : 166)
Query Neighborhood Hits	235	Target Neighborhood Hits	1376	Shared Neighborhood Hits	134
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ES8L1_HUMAN
NC score	0.100303 (rank : 217)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	235	Target Neighborhood Hits	162	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

M3KL4_HUMAN
NC score	0.099556 (rank : 218)	θ value	0.0961366 (rank : 146)
Query Neighborhood Hits	235	Target Neighborhood Hits	1087	Shared Neighborhood Hits	145
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

FYN_MOUSE
NC score	0.098238 (rank : 219)	θ value	0.21417 (rank : 153)
Query Neighborhood Hits	235	Target Neighborhood Hits	1073	Shared Neighborhood Hits	158
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FYN_HUMAN
NC score	0.095981 (rank : 220)	θ value	0.21417 (rank : 152)
Query Neighborhood Hits	235	Target Neighborhood Hits	1078	Shared Neighborhood Hits	158
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

M3K11_HUMAN
NC score	0.095705 (rank : 221)	θ value	0.0431538 (rank : 135)
Query Neighborhood Hits	235	Target Neighborhood Hits	1136	Shared Neighborhood Hits	152
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

YES_MOUSE
NC score	0.095312 (rank : 222)	θ value	1.06291 (rank : 181)
Query Neighborhood Hits	235	Target Neighborhood Hits	1052	Shared Neighborhood Hits	152
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3K9_HUMAN
NC score	0.094781 (rank : 223)	θ value	0.0148317 (rank : 126)
Query Neighborhood Hits	235	Target Neighborhood Hits	1123	Shared Neighborhood Hits	152
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

YES_HUMAN
NC score	0.094496 (rank : 224)	θ value	1.06291 (rank : 180)
Query Neighborhood Hits	235	Target Neighborhood Hits	1059	Shared Neighborhood Hits	152
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

HGS_HUMAN
NC score	0.093984 (rank : 225)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	235	Target Neighborhood Hits	517	Shared Neighborhood Hits	31
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

P85B_HUMAN
NC score	0.093568 (rank : 226)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	235	Target Neighborhood Hits	543	Shared Neighborhood Hits	67
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

HGS_MOUSE
NC score	0.093227 (rank : 227)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	235	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

GRP3_HUMAN
NC score	0.093171 (rank : 228)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	235	Target Neighborhood Hits	131	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

AMPH_HUMAN
NC score	0.092323 (rank : 229)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	235	Target Neighborhood Hits	455	Shared Neighborhood Hits	78
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RUSC2_HUMAN
NC score	0.091735 (rank : 230)	θ value	3.0926 (rank : 215)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

STS2_HUMAN
NC score	0.091610 (rank : 231)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	74
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SRC_HUMAN
NC score	0.090990 (rank : 232)	θ value	1.06291 (rank : 179)
Query Neighborhood Hits	235	Target Neighborhood Hits	1058	Shared Neighborhood Hits	153
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SPN90_MOUSE
NC score	0.090408 (rank : 233)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

EM55_HUMAN
NC score	0.090395 (rank : 234)	θ value	1.81305 (rank : 193)
Query Neighborhood Hits	235	Target Neighborhood Hits	228	Shared Neighborhood Hits	90
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

P85B_MOUSE
NC score	0.090256 (rank : 235)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	235	Target Neighborhood Hits	519	Shared Neighborhood Hits	67
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

FGR_HUMAN
NC score	0.090138 (rank : 236)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	235	Target Neighborhood Hits	1067	Shared Neighborhood Hits	153
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

AMPH_MOUSE
NC score	0.089905 (rank : 237)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	235	Target Neighborhood Hits	291	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

FGR_MOUSE
NC score	0.089465 (rank : 238)	θ value	2.36792 (rank : 203)
Query Neighborhood Hits	235	Target Neighborhood Hits	1069	Shared Neighborhood Hits	151
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SNX9_MOUSE
NC score	0.087547 (rank : 239)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	235	Target Neighborhood Hits	141	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

ZFY28_HUMAN
NC score	0.087314 (rank : 240)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	235	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

BTK_HUMAN
NC score	0.087109 (rank : 241)	θ value	0.0736092 (rank : 141)
Query Neighborhood Hits	235	Target Neighborhood Hits	1026	Shared Neighborhood Hits	144
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

EM55_MOUSE
NC score	0.085723 (rank : 242)	θ value	2.36792 (rank : 202)
Query Neighborhood Hits	235	Target Neighborhood Hits	221	Shared Neighborhood Hits	88
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ZFYV9_HUMAN
NC score	0.085659 (rank : 243)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	235	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

SLAP2_HUMAN
NC score	0.085557 (rank : 244)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	235	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLY_MOUSE
NC score	0.085278 (rank : 245)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SLAP2_MOUSE
NC score	0.084779 (rank : 246)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	235	Target Neighborhood Hits	136	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

DOCK1_HUMAN
NC score	0.084043 (rank : 247)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	100
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ZFY16_MOUSE
NC score	0.081437 (rank : 248)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	235	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

RUSC2_MOUSE
NC score	0.081404 (rank : 249)	θ value	4.03905 (rank : 219)
Query Neighborhood Hits	235	Target Neighborhood Hits	305	Shared Neighborhood Hits	60
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

LMO7_HUMAN
NC score	0.080654 (rank : 250)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	235	Target Neighborhood Hits	507	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

FRK_HUMAN
NC score	0.080205 (rank : 251)	θ value	0.0563607 (rank : 139)
Query Neighborhood Hits	235	Target Neighborhood Hits	1058	Shared Neighborhood Hits	155
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HCK_HUMAN
NC score	0.079986 (rank : 252)	θ value	1.06291 (rank : 174)
Query Neighborhood Hits	235	Target Neighborhood Hits	1035	Shared Neighborhood Hits	145
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ZFY16_HUMAN
NC score	0.079060 (rank : 253)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	235	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

HCK_MOUSE
NC score	0.078828 (rank : 254)	θ value	3.0926 (rank : 210)
Query Neighborhood Hits	235	Target Neighborhood Hits	1029	Shared Neighborhood Hits	145
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SLY_HUMAN
NC score	0.078821 (rank : 255)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	235	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

ZFY21_MOUSE
NC score	0.078562 (rank : 256)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

CHIN_MOUSE
NC score	0.078204 (rank : 257)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	235	Target Neighborhood Hits	229	Shared Neighborhood Hits	44
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

BIN1_HUMAN
NC score	0.078109 (rank : 258)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	235	Target Neighborhood Hits	335	Shared Neighborhood Hits	67
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BTK_MOUSE
NC score	0.078053 (rank : 259)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	235	Target Neighborhood Hits	1017	Shared Neighborhood Hits	137
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

M3K10_HUMAN
NC score	0.077981 (rank : 260)	θ value	0.62314 (rank : 165)
Query Neighborhood Hits	235	Target Neighborhood Hits	1071	Shared Neighborhood Hits	136
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

BIN1_MOUSE
NC score	0.077608 (rank : 261)	θ value	8.99809 (rank : 229)
Query Neighborhood Hits	235	Target Neighborhood Hits	283	Shared Neighborhood Hits	73
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CHIN_HUMAN
NC score	0.077524 (rank : 262)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	41
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.076974 (rank : 263)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	235	Target Neighborhood Hits	220	Shared Neighborhood Hits	41
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

P55G_HUMAN
NC score	0.076438 (rank : 264)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	235	Target Neighborhood Hits	451	Shared Neighborhood Hits	50
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PTK6_MOUSE
NC score	0.076413 (rank : 265)	θ value	0.0736092 (rank : 144)
Query Neighborhood Hits	235	Target Neighborhood Hits	1026	Shared Neighborhood Hits	134
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ZFY21_HUMAN
NC score	0.076408 (rank : 266)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	235	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

SRC_MOUSE
NC score	0.076122 (rank : 267)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	235	Target Neighborhood Hits	1033	Shared Neighborhood Hits	132
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

PTK6_HUMAN
NC score	0.075662 (rank : 268)	θ value	0.0113563 (rank : 121)
Query Neighborhood Hits	235	Target Neighborhood Hits	1020	Shared Neighborhood Hits	135
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

P55G_MOUSE
NC score	0.074156 (rank : 269)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	235	Target Neighborhood Hits	401	Shared Neighborhood Hits	46
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHC3_MOUSE
NC score	0.071974 (rank : 270)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	37
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHB_MOUSE
NC score	0.071755 (rank : 271)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	36
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHE_MOUSE
NC score	0.071176 (rank : 272)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	235	Target Neighborhood Hits	169	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MPP6_HUMAN
NC score	0.070610 (rank : 273)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

LYN_HUMAN
NC score	0.069941 (rank : 274)	θ value	8.99809 (rank : 231)
Query Neighborhood Hits	235	Target Neighborhood Hits	1022	Shared Neighborhood Hits	130
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MIA_MOUSE
NC score	0.069684 (rank : 275)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	235	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MIA_HUMAN
NC score	0.069159 (rank : 276)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	235	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

SHE_HUMAN
NC score	0.069124 (rank : 277)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	235	Target Neighborhood Hits	164	Shared Neighborhood Hits	36
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

RASA1_HUMAN
NC score	0.068853 (rank : 278)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	235	Target Neighborhood Hits	258	Shared Neighborhood Hits	54
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SHD_MOUSE
NC score	0.068738 (rank : 279)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	36
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

MPP6_MOUSE
NC score	0.068531 (rank : 280)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	235	Target Neighborhood Hits	187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

BLK_HUMAN
NC score	0.068091 (rank : 281)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	235	Target Neighborhood Hits	994	Shared Neighborhood Hits	115
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHB_HUMAN
NC score	0.068053 (rank : 282)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	235	Target Neighborhood Hits	141	Shared Neighborhood Hits	37
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

LYN_MOUSE
NC score	0.067931 (rank : 283)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	235	Target Neighborhood Hits	1023	Shared Neighborhood Hits	130
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CIP4_HUMAN
NC score	0.067731 (rank : 284)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	235	Target Neighborhood Hits	374	Shared Neighborhood Hits	62
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

RBNS5_HUMAN
NC score	0.067528 (rank : 285)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

DAPP1_HUMAN
NC score	0.067513 (rank : 286)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	235	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.067041 (rank : 287)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	235	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

REPS2_HUMAN
NC score	0.066201 (rank : 288)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	235	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ABL1_HUMAN
NC score	0.066077 (rank : 289)	θ value	3.0926 (rank : 206)
Query Neighborhood Hits	235	Target Neighborhood Hits	1220	Shared Neighborhood Hits	108
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SLAP1_HUMAN
NC score	0.065772 (rank : 290)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	235	Target Neighborhood Hits	113	Shared Neighborhood Hits	34
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

ABL1_MOUSE
NC score	0.065667 (rank : 291)	θ value	3.0926 (rank : 207)
Query Neighborhood Hits	235	Target Neighborhood Hits	1178	Shared Neighborhood Hits	106
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CHIO_MOUSE
NC score	0.065591 (rank : 292)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	235	Target Neighborhood Hits	130	Shared Neighborhood Hits	20
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

REPS2_MOUSE
NC score	0.065161 (rank : 293)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	235	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

BLK_MOUSE
NC score	0.064858 (rank : 294)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	235	Target Neighborhood Hits	992	Shared Neighborhood Hits	106
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

STS1_HUMAN
NC score	0.064388 (rank : 295)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	235	Target Neighborhood Hits	106	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.064341 (rank : 296)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	235	Target Neighborhood Hits	104	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SLAP1_MOUSE
NC score	0.064053 (rank : 297)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	235	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SHC2_MOUSE
NC score	0.063906 (rank : 298)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	235	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

RPGF1_HUMAN
NC score	0.063527 (rank : 299)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	235	Target Neighborhood Hits	262	Shared Neighborhood Hits	14
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RHG09_HUMAN
NC score	0.062777 (rank : 300)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	235	Target Neighborhood Hits	186	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

SASH1_HUMAN
NC score	0.062740 (rank : 301)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	235	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

RBNS5_MOUSE
NC score	0.062688 (rank : 302)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	20
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

CSK_MOUSE
NC score	0.062428 (rank : 303)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	235	Target Neighborhood Hits	1009	Shared Neighborhood Hits	108
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

SHC2_HUMAN
NC score	0.062278 (rank : 304)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	38
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

CSK_HUMAN
NC score	0.062257 (rank : 305)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	235	Target Neighborhood Hits	1009	Shared Neighborhood Hits	108
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TEC_HUMAN
NC score	0.061930 (rank : 306)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	235	Target Neighborhood Hits	1006	Shared Neighborhood Hits	118
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

DLG2_MOUSE
NC score	0.061139 (rank : 307)	θ value	2.36792 (rank : 201)
Query Neighborhood Hits	235	Target Neighborhood Hits	271	Shared Neighborhood Hits	78
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

ABL2_HUMAN
NC score	0.061106 (rank : 308)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	235	Target Neighborhood Hits	1045	Shared Neighborhood Hits	98
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SHC3_HUMAN
NC score	0.061021 (rank : 309)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	235	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHD_HUMAN
NC score	0.060682 (rank : 310)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC1_HUMAN
NC score	0.060580 (rank : 311)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	235	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

REPS1_MOUSE
NC score	0.060486 (rank : 312)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RHG12_HUMAN
NC score	0.060218 (rank : 313)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	235	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DLG2_HUMAN
NC score	0.060129 (rank : 314)	θ value	2.36792 (rank : 200)
Query Neighborhood Hits	235	Target Neighborhood Hits	279	Shared Neighborhood Hits	77
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SHC1_MOUSE
NC score	0.059925 (rank : 315)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	235	Target Neighborhood Hits	180	Shared Neighborhood Hits	38
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

APS_HUMAN
NC score	0.059822 (rank : 316)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	235	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CNN1_HUMAN
NC score	0.059726 (rank : 317)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	235	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
NC score	0.059622 (rank : 318)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	235	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

SAMN1_HUMAN
NC score	0.059481 (rank : 319)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	235	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

DLG4_HUMAN
NC score	0.059411 (rank : 320)	θ value	0.62314 (rank : 164)
Query Neighborhood Hits	235	Target Neighborhood Hits	286	Shared Neighborhood Hits	77
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

RHG12_MOUSE
NC score	0.059087 (rank : 321)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	235	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CNN2_MOUSE
NC score	0.059064 (rank : 322)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	235	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

TEC_MOUSE
NC score	0.059011 (rank : 323)	θ value	1.38821 (rank : 189)
Query Neighborhood Hits	235	Target Neighborhood Hits	1006	Shared Neighborhood Hits	117
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_MOUSE
NC score	0.058922 (rank : 324)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	235	Target Neighborhood Hits	980	Shared Neighborhood Hits	111
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LNK_HUMAN
NC score	0.058552 (rank : 325)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	235	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
NC score	0.057661 (rank : 326)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	235	Target Neighborhood Hits	132	Shared Neighborhood Hits	33
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SASH1_MOUSE
NC score	0.057602 (rank : 327)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	235	Target Neighborhood Hits	263	Shared Neighborhood Hits	51
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

FYV1_HUMAN
NC score	0.057466 (rank : 328)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	235	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

SAMN1_MOUSE
NC score	0.057001 (rank : 329)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	235	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

ALS2_MOUSE
NC score	0.056996 (rank : 330)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	235	Target Neighborhood Hits	111	Shared Neighborhood Hits	17
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CNN3_MOUSE
NC score	0.056369 (rank : 331)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	235	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_HUMAN
NC score	0.056242 (rank : 332)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	235	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

DLG4_MOUSE
NC score	0.056237 (rank : 333)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	235	Target Neighborhood Hits	282	Shared Neighborhood Hits	74
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG3_MOUSE
NC score	0.056152 (rank : 334)	θ value	5.27518 (rank : 222)
Query Neighborhood Hits	235	Target Neighborhood Hits	274	Shared Neighborhood Hits	75
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

RGL1_HUMAN
NC score	0.056101 (rank : 335)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	235	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

DLG3_HUMAN
NC score	0.055996 (rank : 336)	θ value	5.27518 (rank : 221)
Query Neighborhood Hits	235	Target Neighborhood Hits	269	Shared Neighborhood Hits	75
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

REPS1_HUMAN
NC score	0.055972 (rank : 337)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	235	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

GRB14_MOUSE
NC score	0.055890 (rank : 338)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	235	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_HUMAN
NC score	0.055854 (rank : 339)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	235	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

FYV1_MOUSE
NC score	0.055696 (rank : 340)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	235	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

PKHA6_HUMAN
NC score	0.055445 (rank : 341)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	235	Target Neighborhood Hits	556	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CNN2_HUMAN
NC score	0.055302 (rank : 342)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	235	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

RPGF2_HUMAN
NC score	0.055263 (rank : 343)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	235	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

MPP5_HUMAN
NC score	0.055254 (rank : 344)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	235	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

ITK_HUMAN
NC score	0.055173 (rank : 345)	θ value	1.81305 (rank : 195)
Query Neighborhood Hits	235	Target Neighborhood Hits	1016	Shared Neighborhood Hits	116
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

DLG1_HUMAN
NC score	0.054849 (rank : 346)	θ value	5.27518 (rank : 220)
Query Neighborhood Hits	235	Target Neighborhood Hits	290	Shared Neighborhood Hits	71
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

ZFY19_HUMAN
NC score	0.054637 (rank : 347)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	235	Target Neighborhood Hits	206	Shared Neighborhood Hits	11
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

TXK_HUMAN
NC score	0.054373 (rank : 348)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	235	Target Neighborhood Hits	971	Shared Neighborhood Hits	101
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

MPP5_MOUSE
NC score	0.054236 (rank : 349)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	235	Target Neighborhood Hits	226	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

PKHA6_MOUSE
NC score	0.054110 (rank : 350)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	235	Target Neighborhood Hits	591	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

EEA1_MOUSE
NC score	0.053927 (rank : 351)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	235	Target Neighborhood Hits	1637	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

LCK_HUMAN
NC score	0.053298 (rank : 352)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	235	Target Neighborhood Hits	987	Shared Neighborhood Hits	97
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
NC score	0.053028 (rank : 353)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	235	Target Neighborhood Hits	981	Shared Neighborhood Hits	96
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

GRB7_MOUSE
NC score	0.052696 (rank : 354)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	235	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

RUFY2_HUMAN
NC score	0.052618 (rank : 355)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	235	Target Neighborhood Hits	1208	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RGL1_MOUSE
NC score	0.052326 (rank : 356)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	235	Target Neighborhood Hits	42	Shared Neighborhood Hits	6
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

ZFY19_MOUSE
NC score	0.052256 (rank : 357)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	235	Target Neighborhood Hits	143	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RPGF6_HUMAN
NC score	0.052211 (rank : 358)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	235	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

EEA1_HUMAN
NC score	0.051700 (rank : 359)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	235	Target Neighborhood Hits	1796	Shared Neighborhood Hits	57
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

MPP2_HUMAN
NC score	0.051582 (rank : 360)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	235	Target Neighborhood Hits	173	Shared Neighborhood Hits	62
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

RUFY2_MOUSE
NC score	0.050816 (rank : 361)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	235	Target Neighborhood Hits	820	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ALS2_HUMAN
NC score	0.050639 (rank : 362)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	235	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

RUFY1_HUMAN
NC score	0.050594 (rank : 363)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	235	Target Neighborhood Hits	848	Shared Neighborhood Hits	33
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

HSH2D_HUMAN
NC score	0.050353 (rank : 364)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	235	Target Neighborhood Hits	159	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SPTB2_HUMAN
NC score	0.050343 (rank : 365)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	235	Target Neighborhood Hits	748	Shared Neighborhood Hits	34
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.050215 (rank : 366)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	235	Target Neighborhood Hits	770	Shared Neighborhood Hits	37
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MPP2_MOUSE
NC score	0.050161 (rank : 367)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	235	Target Neighborhood Hits	189	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

RPGF4_HUMAN
NC score	0.050057 (rank : 368)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	235	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

ITK_MOUSE
NC score	0.049357 (rank : 369)	θ value	1.81305 (rank : 196)
Query Neighborhood Hits	235	Target Neighborhood Hits	985	Shared Neighborhood Hits	100
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

CSKP_MOUSE
NC score	0.042348 (rank : 370)	θ value	1.81305 (rank : 192)
Query Neighborhood Hits	235	Target Neighborhood Hits	1027	Shared Neighborhood Hits	115
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.041934 (rank : 371)	θ value	2.36792 (rank : 199)
Query Neighborhood Hits	235	Target Neighborhood Hits	1022	Shared Neighborhood Hits	109
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

SYNE1_HUMAN
NC score	0.041620 (rank : 372)	θ value	3.0926 (rank : 216)
Query Neighborhood Hits	235	Target Neighborhood Hits	1484	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

MATK_HUMAN
NC score	0.041478 (rank : 373)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	235	Target Neighborhood Hits	954	Shared Neighborhood Hits	68
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

IF3A_MOUSE
NC score	0.034459 (rank : 374)	θ value	1.81305 (rank : 194)
Query Neighborhood Hits	235	Target Neighborhood Hits	871	Shared Neighborhood Hits	25
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IF3A_HUMAN
NC score	0.033112 (rank : 375)	θ value	1.38821 (rank : 186)
Query Neighborhood Hits	235	Target Neighborhood Hits	875	Shared Neighborhood Hits	23
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

AKAP9_HUMAN
NC score	0.030535 (rank : 376)	θ value	1.81305 (rank : 191)
Query Neighborhood Hits	235	Target Neighborhood Hits	1710	Shared Neighborhood Hits	52
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

INCE_MOUSE
NC score	0.030443 (rank : 377)	θ value	3.0926 (rank : 211)
Query Neighborhood Hits	235	Target Neighborhood Hits	903	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

TBCD7_MOUSE
NC score	0.028768 (rank : 378)	θ value	1.38821 (rank : 188)
Query Neighborhood Hits	235	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D0K0, Q3U0V0	Gene names	Tbc1d7
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 7.

K0423_HUMAN
NC score	0.024112 (rank : 379)	θ value	1.38821 (rank : 187)
Query Neighborhood Hits	235	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

CACB2_MOUSE
NC score	0.016206 (rank : 380)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	235	Target Neighborhood Hits	94	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CC27, Q8C5J5, Q9CTQ6	Gene names	Cacnb2, Cacnlb2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2).

CACB2_HUMAN
NC score	0.014646 (rank : 381)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	235	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

HS105_MOUSE
NC score	0.011607 (rank : 382)	θ value	2.36792 (rank : 204)
Query Neighborhood Hits	235	Target Neighborhood Hits	129	Shared Neighborhood Hits	9
SwissProt Accessions	Q61699, Q3TNS2, Q3UIY8, Q62578, Q62579, Q6A0A5, Q8C430, Q8VCW6	Gene names	Hsph1, Hsp105, Hsp110, Kiaa0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock-related 100 kDa protein E7I) (HSP-E7I) (Heat shock 110 kDa protein) (42 degrees C-HSP).

NCOA3_MOUSE
NC score	0.008841 (rank : 383)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	235	Target Neighborhood Hits	203	Shared Neighborhood Hits	6
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

HS105_HUMAN
NC score	0.007768 (rank : 384)	θ value	5.27518 (rank : 223)
Query Neighborhood Hits	235	Target Neighborhood Hits	209	Shared Neighborhood Hits	8
SwissProt Accessions	Q92598, O95739, Q5TBM6, Q5TBM8, Q9UPC4	Gene names	HSPH1, HSP105, HSP110, KIAA0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY- CO-25).

SEP11_MOUSE
NC score	0.007701 (rank : 385)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	235	Target Neighborhood Hits	300	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C1B7, Q6P2K5, Q6P6I0	Gene names	Sept11, D5Ertd606e
Domain Architecture	No domain graphic available
Description	Septin-11.

NCOA3_HUMAN
NC score	0.005275 (rank : 386)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	235	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

PAX4_HUMAN
NC score	-0.002904 (rank : 387)	θ value	5.27518 (rank : 224)
Query Neighborhood Hits	235	Target Neighborhood Hits	367	Shared Neighborhood Hits	2
SwissProt Accessions	O43316, O95161, Q6B0H0	Gene names	PAX4
Domain Architecture
Description	Paired box protein Pax-4.

EDNRA_MOUSE
NC score	-0.005373 (rank : 388)	θ value	8.99809 (rank : 230)
Query Neighborhood Hits	235	Target Neighborhood Hits	558	Shared Neighborhood Hits	4
SwissProt Accessions	Q61614, O54993, Q91VV2	Gene names	Ednra, Gpcr10
Domain Architecture
Description	Endothelin-1 receptor precursor (Endothelin A receptor) (ET-A) (ET- AR).