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Network neighborhood for query Sequence : RGL1_MOUSE

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RGL1_MOUSE
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RGL1_HUMAN
θ value	0 (rank : 1)	NC score	0.996409 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
θ value	1.12976e-135 (rank : 3)	NC score	0.945276 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
θ value	1.24909e-134 (rank : 4)	NC score	0.929139 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
θ value	1.76739e-88 (rank : 5)	NC score	0.939693 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
θ value	3.44927e-84 (rank : 6)	NC score	0.934307 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGDSR_HUMAN
θ value	3.47335e-60 (rank : 7)	NC score	0.914902 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

GNRP_HUMAN
θ value	2.77131e-33 (rank : 8)	NC score	0.610784 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	3.28125e-26 (rank : 9)	NC score	0.593716 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
θ value	8.08199e-25 (rank : 10)	NC score	0.593599 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
θ value	3.39556e-23 (rank : 11)	NC score	0.589425 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
θ value	2.43343e-21 (rank : 12)	NC score	0.617077 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GRP3_HUMAN
θ value	1.92812e-18 (rank : 13)	NC score	0.538330 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF1_HUMAN
θ value	3.28887e-18 (rank : 14)	NC score	0.695315 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF6_HUMAN
θ value	1.42992e-13 (rank : 15)	NC score	0.494152 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF2_HUMAN
θ value	1.02475e-11 (rank : 16)	NC score	0.507644 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF4_MOUSE
θ value	3.08544e-08 (rank : 17)	NC score	0.428497 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	80	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
θ value	4.0297e-08 (rank : 18)	NC score	0.432624 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF5_MOUSE
θ value	1.99992e-07 (rank : 19)	NC score	0.468419 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	5.81887e-07 (rank : 20)	NC score	0.482621 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

CF152_HUMAN
θ value	0.00509761 (rank : 21)	NC score	0.035385 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	704	Shared Neighborhood Hits	10
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

RPGF3_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.375674 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

TIAM1_HUMAN
θ value	0.365318 (rank : 23)	NC score	0.068326 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

AP180_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.048622 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

AP180_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.048181 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

CCD39_HUMAN
θ value	0.47712 (rank : 26)	NC score	0.011104 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	868	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

TIAM1_MOUSE
θ value	0.47712 (rank : 27)	NC score	0.065864 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

BRCA2_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.024181 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

CD2L7_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.001985 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	1275	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

RPGF3_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.331273 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PMS2_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.013136 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	P54279	Gene names	Pms2
Domain Architecture
Description	PMS1 protein homolog 2 (DNA mismatch repair protein PMS2).

TGON2_HUMAN
θ value	4.03905 (rank : 32)	NC score	0.006770 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	1037	Shared Neighborhood Hits	6
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

PCDBD_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.000766 (rank : 50)
Query Neighborhood Hits	42	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5F0	Gene names	PCDHB13
Domain Architecture
Description	Protocadherin beta 13 precursor (PCDH-beta13).

RTP3_MOUSE
θ value	5.27518 (rank : 34)	NC score	0.008381 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	374	Shared Neighborhood Hits	2
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SM1L2_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.004062 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	918	Shared Neighborhood Hits	6
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

TMCC1_MOUSE
θ value	5.27518 (rank : 36)	NC score	0.016264 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	315	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

C8AP2_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.008679 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	405	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

NIN_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.001509 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	1376	Shared Neighborhood Hits	9
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

SFR16_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.013111 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

KHK_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.015961 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P50053, Q99532, Q9BRJ3, Q9UMN1	Gene names	KHK
Domain Architecture
Description	Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase).

LAMA1_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.000662 (rank : 51)
Query Neighborhood Hits	42	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

TMCC1_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.014243 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	337	Shared Neighborhood Hits	7
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

ARHG4_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.053486 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.052326 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.052595 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	234	Shared Neighborhood Hits	6
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CB027_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.056262 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	29	Shared Neighborhood Hits	1
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ECT2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.061631 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.058720 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.050022 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	249	Shared Neighborhood Hits	7
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

NGEF_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.052556 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	166	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PREX1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.083261 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

Hits sorted by NC score

RGL1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_HUMAN
NC score	0.996409 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.945276 (rank : 3)	θ value	1.12976e-135 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
NC score	0.939693 (rank : 4)	θ value	1.76739e-88 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
NC score	0.934307 (rank : 5)	θ value	3.44927e-84 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_HUMAN
NC score	0.929139 (rank : 6)	θ value	1.24909e-134 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGDSR_HUMAN
NC score	0.914902 (rank : 7)	θ value	3.47335e-60 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF1_HUMAN
NC score	0.695315 (rank : 8)	θ value	3.28887e-18 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS2_HUMAN
NC score	0.617077 (rank : 9)	θ value	2.43343e-21 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_HUMAN
NC score	0.610784 (rank : 10)	θ value	2.77131e-33 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.593716 (rank : 11)	θ value	3.28125e-26 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
NC score	0.593599 (rank : 12)	θ value	8.08199e-25 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.589425 (rank : 13)	θ value	3.39556e-23 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	274	Shared Neighborhood Hits	24
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GRP3_HUMAN
NC score	0.538330 (rank : 14)	θ value	1.92812e-18 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF2_HUMAN
NC score	0.507644 (rank : 15)	θ value	1.02475e-11 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.494152 (rank : 16)	θ value	1.42992e-13 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF5_HUMAN
NC score	0.482621 (rank : 17)	θ value	5.81887e-07 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
NC score	0.468419 (rank : 18)	θ value	1.99992e-07 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.432624 (rank : 19)	θ value	4.0297e-08 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.428497 (rank : 20)	θ value	3.08544e-08 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	80	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.375674 (rank : 21)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.331273 (rank : 22)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
NC score	0.083261 (rank : 23)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_HUMAN
NC score	0.068326 (rank : 24)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	225	Shared Neighborhood Hits	9
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.065864 (rank : 25)	θ value	0.47712 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ECT2_HUMAN
NC score	0.061631 (rank : 26)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
NC score	0.058720 (rank : 27)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

CB027_HUMAN
NC score	0.056262 (rank : 28)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	29	Shared Neighborhood Hits	1
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ARHG4_HUMAN
NC score	0.053486 (rank : 29)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
NC score	0.052595 (rank : 30)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	234	Shared Neighborhood Hits	6
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

NGEF_HUMAN
NC score	0.052556 (rank : 31)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	42	Target Neighborhood Hits	166	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG9_HUMAN
NC score	0.052326 (rank : 32)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

FGD3_HUMAN
NC score	0.050022 (rank : 33)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	249	Shared Neighborhood Hits	7
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

AP180_HUMAN
NC score	0.048622 (rank : 34)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

AP180_MOUSE
NC score	0.048181 (rank : 35)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

CF152_HUMAN
NC score	0.035385 (rank : 36)	θ value	0.00509761 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	704	Shared Neighborhood Hits	10
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

BRCA2_HUMAN
NC score	0.024181 (rank : 37)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

TMCC1_MOUSE
NC score	0.016264 (rank : 38)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	315	Shared Neighborhood Hits	7
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

KHK_HUMAN
NC score	0.015961 (rank : 39)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P50053, Q99532, Q9BRJ3, Q9UMN1	Gene names	KHK
Domain Architecture
Description	Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase).

TMCC1_HUMAN
NC score	0.014243 (rank : 40)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	337	Shared Neighborhood Hits	7
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

PMS2_MOUSE
NC score	0.013136 (rank : 41)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	P54279	Gene names	Pms2
Domain Architecture
Description	PMS1 protein homolog 2 (DNA mismatch repair protein PMS2).

SFR16_MOUSE
NC score	0.013111 (rank : 42)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

CCD39_HUMAN
NC score	0.011104 (rank : 43)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	868	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

C8AP2_MOUSE
NC score	0.008679 (rank : 44)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	405	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

RTP3_MOUSE
NC score	0.008381 (rank : 45)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	374	Shared Neighborhood Hits	2
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

TGON2_HUMAN
NC score	0.006770 (rank : 46)	θ value	4.03905 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	1037	Shared Neighborhood Hits	6
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

SM1L2_MOUSE
NC score	0.004062 (rank : 47)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	918	Shared Neighborhood Hits	6
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

CD2L7_HUMAN
NC score	0.001985 (rank : 48)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	1275	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

NIN_MOUSE
NC score	0.001509 (rank : 49)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	1376	Shared Neighborhood Hits	9
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

PCDBD_HUMAN
NC score	0.000766 (rank : 50)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5F0	Gene names	PCDHB13
Domain Architecture
Description	Protocadherin beta 13 precursor (PCDH-beta13).

LAMA1_MOUSE
NC score	0.000662 (rank : 51)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	838	Shared Neighborhood Hits	9
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).