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Network neighborhood for query Sequence : RPGF5_HUMAN

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RPGF5_HUMAN
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RPGF5_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
θ value	0 (rank : 2)	NC score	0.989613 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	85	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
θ value	1.52691e-132 (rank : 3)	NC score	0.927345 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	1.42914e-130 (rank : 4)	NC score	0.926222 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
θ value	1.95407e-87 (rank : 5)	NC score	0.908614 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	1.65422e-86 (rank : 6)	NC score	0.900159 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF2_HUMAN
θ value	1.2411e-41 (rank : 7)	NC score	0.745059 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	4.41421e-39 (rank : 8)	NC score	0.710408 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	266	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GNRP_HUMAN
θ value	3.07116e-24 (rank : 9)	NC score	0.571266 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RPGF1_HUMAN
θ value	2.59989e-23 (rank : 10)	NC score	0.756449 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GNRP_MOUSE
θ value	1.2077e-20 (rank : 11)	NC score	0.555252 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_HUMAN
θ value	1.38178e-16 (rank : 12)	NC score	0.553799 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	1.80466e-16 (rank : 13)	NC score	0.554013 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	2.20605e-14 (rank : 14)	NC score	0.568954 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	193	Shared Neighborhood Hits	23
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GRP3_HUMAN
θ value	1.58096e-12 (rank : 15)	NC score	0.537160 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	131	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RGL1_HUMAN
θ value	5.26297e-08 (rank : 16)	NC score	0.513142 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
θ value	1.17247e-07 (rank : 17)	NC score	0.484102 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
θ value	4.45536e-07 (rank : 18)	NC score	0.469349 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
θ value	5.81887e-07 (rank : 19)	NC score	0.482621 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_MOUSE
θ value	1.69304e-06 (rank : 20)	NC score	0.474611 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
θ value	5.44631e-05 (rank : 21)	NC score	0.466306 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

SH2D3_MOUSE
θ value	0.000461057 (rank : 22)	NC score	0.150681 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	174	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH2D3_HUMAN
θ value	0.00134147 (rank : 23)	NC score	0.142969 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SAS6_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.043529 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	791	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

RASF2_MOUSE
θ value	0.0193708 (rank : 25)	NC score	0.058313 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMS9, Q6A0B2	Gene names	Rassf2, Kiaa0168
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 2.

RASF2_HUMAN
θ value	0.0252991 (rank : 26)	NC score	0.057522 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P50749, Q53HD0, Q6AHZ2	Gene names	RASSF2, KIAA0168
Domain Architecture
Description	Ras association domain-containing protein 2.

RGDSR_HUMAN
θ value	0.0563607 (rank : 27)	NC score	0.398258 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

SAS6_MOUSE
θ value	0.0563607 (rank : 28)	NC score	0.035898 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	931	Shared Neighborhood Hits	12
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

BLNK_HUMAN
θ value	0.365318 (rank : 29)	NC score	0.041501 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

EEA1_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.012459 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	1796	Shared Neighborhood Hits	11
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

KIF11_MOUSE
θ value	0.62314 (rank : 31)	NC score	0.013286 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	446	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P9P6, Q9Z1J0	Gene names	Kif11
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5).

ROCK2_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.002589 (rank : 54)
Query Neighborhood Hits	42	Target Neighborhood Hits	2073	Shared Neighborhood Hits	13
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CENPE_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.005573 (rank : 53)
Query Neighborhood Hits	42	Target Neighborhood Hits	2060	Shared Neighborhood Hits	11
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

RASF6_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.038300 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZTQ3, Q68DT2, Q6PDA6, Q86WG9, Q86WH0	Gene names	RASSF6
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 6.

BPAEA_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.007340 (rank : 52)
Query Neighborhood Hits	42	Target Neighborhood Hits	1480	Shared Neighborhood Hits	13
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CP2BA_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.000932 (rank : 55)
Query Neighborhood Hits	42	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	P12791	Gene names	Cyp2b10, Cyp2b-10
Domain Architecture
Description	Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46).

KIF11_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.009518 (rank : 51)
Query Neighborhood Hits	42	Target Neighborhood Hits	583	Shared Neighborhood Hits	10
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

KTN1_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.010631 (rank : 50)
Query Neighborhood Hits	42	Target Neighborhood Hits	1197	Shared Neighborhood Hits	14
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

NEK2_MOUSE
θ value	8.99809 (rank : 39)	NC score	-0.001640 (rank : 57)
Query Neighborhood Hits	42	Target Neighborhood Hits	876	Shared Neighborhood Hits	5
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

PCD15_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.000670 (rank : 56)
Query Neighborhood Hits	42	Target Neighborhood Hits	289	Shared Neighborhood Hits	2
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

RASF6_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.036107 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q80UQ2, Q9DAW2	Gene names	Rassf6
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 6.

TR100_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.012078 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O75448, Q14143, Q9NNY5	Gene names	THRAP4, ARC100, DRIP100, KIAA0130, TRAP100
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 100 kDa component (Trap100) (Thyroid hormone receptor-associated protein 4) (Vitamin D3 receptor-interacting protein complex component DRIP100) (Activator- recruited cofactor 100 kDa component) (ARC100).

BCAR3_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.056591 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CT152_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.192195 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.160892 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

ECT2_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.050477 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FYV1_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.050291 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GP155_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.110523 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

KAP0_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.090718 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.090916 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.109091 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.106434 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.082034 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.083532 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.081797 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.082397 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

PREX1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.152081 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

Hits sorted by NC score

RPGF5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
NC score	0.989613 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	85	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.927345 (rank : 3)	θ value	1.52691e-132 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.926222 (rank : 4)	θ value	1.42914e-130 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.908614 (rank : 5)	θ value	1.95407e-87 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.900159 (rank : 6)	θ value	1.65422e-86 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF1_HUMAN
NC score	0.756449 (rank : 7)	θ value	2.59989e-23 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF2_HUMAN
NC score	0.745059 (rank : 8)	θ value	1.2411e-41 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.710408 (rank : 9)	θ value	4.41421e-39 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	266	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GNRP_HUMAN
NC score	0.571266 (rank : 10)	θ value	3.07116e-24 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	239	Shared Neighborhood Hits	25
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS2_HUMAN
NC score	0.568954 (rank : 11)	θ value	2.20605e-14 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	193	Shared Neighborhood Hits	23
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_MOUSE
NC score	0.555252 (rank : 12)	θ value	1.2077e-20 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
NC score	0.554013 (rank : 13)	θ value	1.80466e-16 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.553799 (rank : 14)	θ value	1.38178e-16 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GRP3_HUMAN
NC score	0.537160 (rank : 15)	θ value	1.58096e-12 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	131	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RGL1_HUMAN
NC score	0.513142 (rank : 16)	θ value	5.26297e-08 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.484102 (rank : 17)	θ value	1.17247e-07 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
NC score	0.482621 (rank : 18)	θ value	5.81887e-07 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_MOUSE
NC score	0.474611 (rank : 19)	θ value	1.69304e-06 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_HUMAN
NC score	0.469349 (rank : 20)	θ value	4.45536e-07 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
NC score	0.466306 (rank : 21)	θ value	5.44631e-05 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGDSR_HUMAN
NC score	0.398258 (rank : 22)	θ value	0.0563607 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

CT152_HUMAN
NC score	0.192195 (rank : 23)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

CT152_MOUSE
NC score	0.160892 (rank : 24)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

PREX1_HUMAN
NC score	0.152081 (rank : 25)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SH2D3_MOUSE
NC score	0.150681 (rank : 26)	θ value	0.000461057 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	174	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH2D3_HUMAN
NC score	0.142969 (rank : 27)	θ value	0.00134147 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

GP155_HUMAN
NC score	0.110523 (rank : 28)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

KAP1_HUMAN
NC score	0.109091 (rank : 29)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	42	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.106434 (rank : 30)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.090916 (rank : 31)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	42	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP0_HUMAN
NC score	0.090718 (rank : 32)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP2_MOUSE
NC score	0.083532 (rank : 33)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	42	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.082397 (rank : 34)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_HUMAN
NC score	0.082034 (rank : 35)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	42	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
NC score	0.081797 (rank : 36)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

RASF2_MOUSE
NC score	0.058313 (rank : 37)	θ value	0.0193708 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMS9, Q6A0B2	Gene names	Rassf2, Kiaa0168
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 2.

RASF2_HUMAN
NC score	0.057522 (rank : 38)	θ value	0.0252991 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P50749, Q53HD0, Q6AHZ2	Gene names	RASSF2, KIAA0168
Domain Architecture
Description	Ras association domain-containing protein 2.

BCAR3_MOUSE
NC score	0.056591 (rank : 39)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ECT2_HUMAN
NC score	0.050477 (rank : 40)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FYV1_MOUSE
NC score	0.050291 (rank : 41)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

SAS6_HUMAN
NC score	0.043529 (rank : 42)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	791	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

BLNK_HUMAN
NC score	0.041501 (rank : 43)	θ value	0.365318 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

RASF6_HUMAN
NC score	0.038300 (rank : 44)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZTQ3, Q68DT2, Q6PDA6, Q86WG9, Q86WH0	Gene names	RASSF6
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 6.

RASF6_MOUSE
NC score	0.036107 (rank : 45)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q80UQ2, Q9DAW2	Gene names	Rassf6
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 6.

SAS6_MOUSE
NC score	0.035898 (rank : 46)	θ value	0.0563607 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	931	Shared Neighborhood Hits	12
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

KIF11_MOUSE
NC score	0.013286 (rank : 47)	θ value	0.62314 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	446	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P9P6, Q9Z1J0	Gene names	Kif11
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5).

EEA1_HUMAN
NC score	0.012459 (rank : 48)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	1796	Shared Neighborhood Hits	11
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TR100_HUMAN
NC score	0.012078 (rank : 49)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	O75448, Q14143, Q9NNY5	Gene names	THRAP4, ARC100, DRIP100, KIAA0130, TRAP100
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 100 kDa component (Trap100) (Thyroid hormone receptor-associated protein 4) (Vitamin D3 receptor-interacting protein complex component DRIP100) (Activator- recruited cofactor 100 kDa component) (ARC100).

KTN1_HUMAN
NC score	0.010631 (rank : 50)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	1197	Shared Neighborhood Hits	14
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

KIF11_HUMAN
NC score	0.009518 (rank : 51)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	583	Shared Neighborhood Hits	10
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

BPAEA_MOUSE
NC score	0.007340 (rank : 52)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	1480	Shared Neighborhood Hits	13
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CENPE_HUMAN
NC score	0.005573 (rank : 53)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	2060	Shared Neighborhood Hits	11
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

ROCK2_HUMAN
NC score	0.002589 (rank : 54)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	2073	Shared Neighborhood Hits	13
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CP2BA_MOUSE
NC score	0.000932 (rank : 55)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	P12791	Gene names	Cyp2b10, Cyp2b-10
Domain Architecture
Description	Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46).

PCD15_HUMAN
NC score	0.000670 (rank : 56)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	289	Shared Neighborhood Hits	2
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

NEK2_MOUSE
NC score	-0.001640 (rank : 57)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	876	Shared Neighborhood Hits	5
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).