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Network neighborhood for query Sequence : BLNK_HUMAN

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BLNK_HUMAN
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BLNK_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	0 (rank : 2)	NC score	0.909692 (rank : 2)
Query Neighborhood Hits	228	Target Neighborhood Hits	296	Shared Neighborhood Hits	132
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

LCP2_HUMAN
θ value	8.08199e-25 (rank : 3)	NC score	0.551823 (rank : 4)
Query Neighborhood Hits	228	Target Neighborhood Hits	531	Shared Neighborhood Hits	96
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	6.20254e-17 (rank : 4)	NC score	0.589905 (rank : 3)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	57
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TEC_HUMAN
θ value	0.00020696 (rank : 5)	NC score	0.122177 (rank : 65)
Query Neighborhood Hits	228	Target Neighborhood Hits	1006	Shared Neighborhood Hits	67
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
θ value	0.00020696 (rank : 6)	NC score	0.117621 (rank : 70)
Query Neighborhood Hits	228	Target Neighborhood Hits	971	Shared Neighborhood Hits	63
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BTK_MOUSE
θ value	0.000270298 (rank : 7)	NC score	0.127205 (rank : 59)
Query Neighborhood Hits	228	Target Neighborhood Hits	1017	Shared Neighborhood Hits	68
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

RASA1_HUMAN
θ value	0.000270298 (rank : 8)	NC score	0.231073 (rank : 14)
Query Neighborhood Hits	228	Target Neighborhood Hits	258	Shared Neighborhood Hits	62
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

BTK_HUMAN
θ value	0.00035302 (rank : 9)	NC score	0.126866 (rank : 60)
Query Neighborhood Hits	228	Target Neighborhood Hits	1026	Shared Neighborhood Hits	68
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BMX_MOUSE
θ value	0.000602161 (rank : 10)	NC score	0.116494 (rank : 71)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TEC_MOUSE
θ value	0.000602161 (rank : 11)	NC score	0.118680 (rank : 68)
Query Neighborhood Hits	228	Target Neighborhood Hits	1006	Shared Neighborhood Hits	63
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PLCG2_HUMAN
θ value	0.000786445 (rank : 12)	NC score	0.236128 (rank : 12)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	62
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

GRAP_MOUSE
θ value	0.00228821 (rank : 13)	NC score	0.240359 (rank : 10)
Query Neighborhood Hits	228	Target Neighborhood Hits	309	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

BMX_HUMAN
θ value	0.00298849 (rank : 14)	NC score	0.115659 (rank : 72)
Query Neighborhood Hits	228	Target Neighborhood Hits	942	Shared Neighborhood Hits	69
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

GRAP_HUMAN
θ value	0.00298849 (rank : 15)	NC score	0.237926 (rank : 11)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	62
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

TXK_MOUSE
θ value	0.00390308 (rank : 16)	NC score	0.113532 (rank : 74)
Query Neighborhood Hits	228	Target Neighborhood Hits	980	Shared Neighborhood Hits	63
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

MLL4_HUMAN
θ value	0.00509761 (rank : 17)	NC score	0.105086 (rank : 81)
Query Neighborhood Hits	228	Target Neighborhood Hits	722	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NCK1_HUMAN
θ value	0.00509761 (rank : 18)	NC score	0.242494 (rank : 7)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

P85B_HUMAN
θ value	0.0113563 (rank : 19)	NC score	0.246352 (rank : 6)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	69
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	0.0113563 (rank : 20)	NC score	0.246567 (rank : 5)
Query Neighborhood Hits	228	Target Neighborhood Hits	519	Shared Neighborhood Hits	64
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CN155_HUMAN
θ value	0.0148317 (rank : 21)	NC score	0.141190 (rank : 43)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

WASL_MOUSE
θ value	0.0193708 (rank : 22)	NC score	0.135950 (rank : 48)
Query Neighborhood Hits	228	Target Neighborhood Hits	339	Shared Neighborhood Hits	34
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

FRK_HUMAN
θ value	0.0252991 (rank : 23)	NC score	0.101780 (rank : 89)
Query Neighborhood Hits	228	Target Neighborhood Hits	1058	Shared Neighborhood Hits	70
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MLL2_HUMAN
θ value	0.0252991 (rank : 24)	NC score	0.086817 (rank : 133)
Query Neighborhood Hits	228	Target Neighborhood Hits	1788	Shared Neighborhood Hits	92
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

VAV3_HUMAN
θ value	0.0252991 (rank : 25)	NC score	0.161739 (rank : 28)
Query Neighborhood Hits	228	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

AFF1_HUMAN
θ value	0.0330416 (rank : 26)	NC score	0.100633 (rank : 91)
Query Neighborhood Hits	228	Target Neighborhood Hits	506	Shared Neighborhood Hits	58
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

CD2L5_HUMAN
θ value	0.0330416 (rank : 27)	NC score	0.044359 (rank : 430)
Query Neighborhood Hits	228	Target Neighborhood Hits	987	Shared Neighborhood Hits	39
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

MBB1A_HUMAN
θ value	0.0330416 (rank : 28)	NC score	0.088551 (rank : 127)
Query Neighborhood Hits	228	Target Neighborhood Hits	665	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

P85A_HUMAN
θ value	0.0330416 (rank : 29)	NC score	0.214345 (rank : 22)
Query Neighborhood Hits	228	Target Neighborhood Hits	479	Shared Neighborhood Hits	62
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	0.0330416 (rank : 30)	NC score	0.216234 (rank : 21)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	60
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TITIN_HUMAN
θ value	0.0330416 (rank : 31)	NC score	0.051973 (rank : 369)
Query Neighborhood Hits	228	Target Neighborhood Hits	2923	Shared Neighborhood Hits	107
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

WASF1_HUMAN
θ value	0.0330416 (rank : 32)	NC score	0.102211 (rank : 87)
Query Neighborhood Hits	228	Target Neighborhood Hits	260	Shared Neighborhood Hits	28
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

ABL1_HUMAN
θ value	0.0431538 (rank : 33)	NC score	0.106618 (rank : 78)
Query Neighborhood Hits	228	Target Neighborhood Hits	1220	Shared Neighborhood Hits	86
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.0431538 (rank : 34)	NC score	0.107791 (rank : 75)
Query Neighborhood Hits	228	Target Neighborhood Hits	1178	Shared Neighborhood Hits	90
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

PTN11_HUMAN
θ value	0.0431538 (rank : 35)	NC score	0.132248 (rank : 53)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.0431538 (rank : 36)	NC score	0.132264 (rank : 52)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

GRB2_HUMAN
θ value	0.0563607 (rank : 37)	NC score	0.216336 (rank : 20)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	62
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.0563607 (rank : 38)	NC score	0.216379 (rank : 19)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	62
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SHC3_MOUSE
θ value	0.0563607 (rank : 39)	NC score	0.214166 (rank : 23)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ECM1_HUMAN
θ value	0.0736092 (rank : 40)	NC score	0.115085 (rank : 73)
Query Neighborhood Hits	228	Target Neighborhood Hits	182	Shared Neighborhood Hits	21
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

LAD1_HUMAN
θ value	0.0736092 (rank : 41)	NC score	0.126406 (rank : 62)
Query Neighborhood Hits	228	Target Neighborhood Hits	441	Shared Neighborhood Hits	47
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

WASF1_MOUSE
θ value	0.0736092 (rank : 42)	NC score	0.099975 (rank : 92)
Query Neighborhood Hits	228	Target Neighborhood Hits	261	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

ZN217_HUMAN
θ value	0.0736092 (rank : 43)	NC score	0.019566 (rank : 492)
Query Neighborhood Hits	228	Target Neighborhood Hits	905	Shared Neighborhood Hits	34
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

ARMX6_HUMAN
θ value	0.0961366 (rank : 44)	NC score	0.066684 (rank : 203)
Query Neighborhood Hits	228	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q7L4S7, Q9NWJ3	Gene names	ARMCX6
Domain Architecture	No domain graphic available
Description	Protein ARMCX6.

SHC3_HUMAN
θ value	0.0961366 (rank : 45)	NC score	0.205746 (rank : 24)
Query Neighborhood Hits	228	Target Neighborhood Hits	155	Shared Neighborhood Hits	51
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

TACC2_HUMAN
θ value	0.0961366 (rank : 46)	NC score	0.056012 (rank : 276)
Query Neighborhood Hits	228	Target Neighborhood Hits	856	Shared Neighborhood Hits	52
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TSH1_MOUSE
θ value	0.0961366 (rank : 47)	NC score	0.040373 (rank : 446)
Query Neighborhood Hits	228	Target Neighborhood Hits	675	Shared Neighborhood Hits	26
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

VAV3_MOUSE
θ value	0.0961366 (rank : 48)	NC score	0.158991 (rank : 30)
Query Neighborhood Hits	228	Target Neighborhood Hits	404	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CCNK_MOUSE
θ value	0.125558 (rank : 49)	NC score	0.085622 (rank : 135)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	35
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

SF3A1_HUMAN
θ value	0.125558 (rank : 50)	NC score	0.089896 (rank : 120)
Query Neighborhood Hits	228	Target Neighborhood Hits	199	Shared Neighborhood Hits	22
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

3BP2_MOUSE
θ value	0.163984 (rank : 51)	NC score	0.102475 (rank : 86)
Query Neighborhood Hits	228	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

GGN_MOUSE
θ value	0.163984 (rank : 52)	NC score	0.090154 (rank : 115)
Query Neighborhood Hits	228	Target Neighborhood Hits	311	Shared Neighborhood Hits	35
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

ROBO1_HUMAN
θ value	0.163984 (rank : 53)	NC score	0.031873 (rank : 464)
Query Neighborhood Hits	228	Target Neighborhood Hits	529	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

BAG3_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.054699 (rank : 295)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	33
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

CD2L5_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.045151 (rank : 429)
Query Neighborhood Hits	228	Target Neighborhood Hits	1011	Shared Neighborhood Hits	48
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

MAP1A_HUMAN
θ value	0.21417 (rank : 56)	NC score	0.064367 (rank : 211)
Query Neighborhood Hits	228	Target Neighborhood Hits	1626	Shared Neighborhood Hits	90
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

PCLO_HUMAN
θ value	0.21417 (rank : 57)	NC score	0.102641 (rank : 85)
Query Neighborhood Hits	228	Target Neighborhood Hits	2046	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ROBO1_MOUSE
θ value	0.21417 (rank : 58)	NC score	0.031337 (rank : 466)
Query Neighborhood Hits	228	Target Neighborhood Hits	559	Shared Neighborhood Hits	11
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ABL2_HUMAN
θ value	0.279714 (rank : 59)	NC score	0.102763 (rank : 83)
Query Neighborhood Hits	228	Target Neighborhood Hits	1045	Shared Neighborhood Hits	75
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ANK2_HUMAN
θ value	0.279714 (rank : 60)	NC score	0.058893 (rank : 244)
Query Neighborhood Hits	228	Target Neighborhood Hits	1615	Shared Neighborhood Hits	98
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

DREB_MOUSE
θ value	0.279714 (rank : 61)	NC score	0.051225 (rank : 387)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

LNK_MOUSE
θ value	0.279714 (rank : 62)	NC score	0.137217 (rank : 47)
Query Neighborhood Hits	228	Target Neighborhood Hits	132	Shared Neighborhood Hits	46
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SNP29_MOUSE
θ value	0.279714 (rank : 63)	NC score	0.088213 (rank : 129)
Query Neighborhood Hits	228	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERB0, Q3UGN0, Q9DBC5	Gene names	Snap29
Domain Architecture
Description	Synaptosomal-associated protein 29 (SNAP-29) (Vesicle-membrane fusion protein SNAP-29) (Soluble 29 kDa NSF attachment protein) (Golgi SNARE of 32 kDa) (Gs32).

DAPP1_MOUSE
θ value	0.365318 (rank : 64)	NC score	0.240809 (rank : 9)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NFH_HUMAN
θ value	0.365318 (rank : 65)	NC score	0.041932 (rank : 437)
Query Neighborhood Hits	228	Target Neighborhood Hits	1242	Shared Neighborhood Hits	65
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

P55G_HUMAN
θ value	0.365318 (rank : 66)	NC score	0.228789 (rank : 15)
Query Neighborhood Hits	228	Target Neighborhood Hits	451	Shared Neighborhood Hits	59
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	0.365318 (rank : 67)	NC score	0.225877 (rank : 16)
Query Neighborhood Hits	228	Target Neighborhood Hits	401	Shared Neighborhood Hits	56
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

RPGF5_HUMAN
θ value	0.365318 (rank : 68)	NC score	0.041501 (rank : 440)
Query Neighborhood Hits	228	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

ZAN_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.038784 (rank : 450)
Query Neighborhood Hits	228	Target Neighborhood Hits	679	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

BRD4_HUMAN
θ value	0.47712 (rank : 70)	NC score	0.072511 (rank : 180)
Query Neighborhood Hits	228	Target Neighborhood Hits	851	Shared Neighborhood Hits	56
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

FER_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.087620 (rank : 130)
Query Neighborhood Hits	228	Target Neighborhood Hits	1278	Shared Neighborhood Hits	70
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ITK_MOUSE
θ value	0.47712 (rank : 72)	NC score	0.105375 (rank : 79)
Query Neighborhood Hits	228	Target Neighborhood Hits	985	Shared Neighborhood Hits	67
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

MLL3_HUMAN
θ value	0.47712 (rank : 73)	NC score	0.083519 (rank : 142)
Query Neighborhood Hits	228	Target Neighborhood Hits	1644	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NCK2_HUMAN
θ value	0.47712 (rank : 74)	NC score	0.233976 (rank : 13)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	63
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NUCL_MOUSE
θ value	0.47712 (rank : 75)	NC score	0.036769 (rank : 455)
Query Neighborhood Hits	228	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PLCG1_HUMAN
θ value	0.47712 (rank : 76)	NC score	0.219421 (rank : 17)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	62
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	0.47712 (rank : 77)	NC score	0.217428 (rank : 18)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SIA7A_HUMAN
θ value	0.47712 (rank : 78)	NC score	0.047596 (rank : 425)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

VGF_HUMAN
θ value	0.47712 (rank : 79)	NC score	0.128502 (rank : 55)
Query Neighborhood Hits	228	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

3BP2_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.126467 (rank : 61)
Query Neighborhood Hits	228	Target Neighborhood Hits	296	Shared Neighborhood Hits	54
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CCDC9_MOUSE
θ value	0.62314 (rank : 81)	NC score	0.076275 (rank : 166)
Query Neighborhood Hits	228	Target Neighborhood Hits	196	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VC31	Gene names	Ccdc9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

COIA1_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.030055 (rank : 470)
Query Neighborhood Hits	228	Target Neighborhood Hits	447	Shared Neighborhood Hits	29
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

DCP1B_HUMAN
θ value	0.62314 (rank : 83)	NC score	0.053807 (rank : 322)
Query Neighborhood Hits	228	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZD4, Q86XH9, Q96BP8, Q96MZ8	Gene names	DCP1B
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1B (EC 3.-.-.-).

GNAS1_MOUSE
θ value	0.62314 (rank : 84)	NC score	0.036932 (rank : 453)
Query Neighborhood Hits	228	Target Neighborhood Hits	651	Shared Neighborhood Hits	50
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HGS_MOUSE
θ value	0.62314 (rank : 85)	NC score	0.031324 (rank : 467)
Query Neighborhood Hits	228	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RPGF5_MOUSE
θ value	0.62314 (rank : 86)	NC score	0.039817 (rank : 447)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

SHAN2_MOUSE
θ value	0.62314 (rank : 87)	NC score	0.087610 (rank : 131)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	45
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

BSN_MOUSE
θ value	0.813845 (rank : 88)	NC score	0.072761 (rank : 179)
Query Neighborhood Hits	228	Target Neighborhood Hits	2057	Shared Neighborhood Hits	101
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

YLPM1_MOUSE
θ value	0.813845 (rank : 89)	NC score	0.069197 (rank : 192)
Query Neighborhood Hits	228	Target Neighborhood Hits	505	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZN509_MOUSE
θ value	0.813845 (rank : 90)	NC score	0.002232 (rank : 523)
Query Neighborhood Hits	228	Target Neighborhood Hits	990	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

NOP14_MOUSE
θ value	1.06291 (rank : 91)	NC score	0.032848 (rank : 460)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R3N1	Gene names	Nop14
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

PELP1_MOUSE
θ value	1.06291 (rank : 92)	NC score	0.067952 (rank : 195)
Query Neighborhood Hits	228	Target Neighborhood Hits	709	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PRG4_MOUSE
θ value	1.06291 (rank : 93)	NC score	0.067140 (rank : 200)
Query Neighborhood Hits	228	Target Neighborhood Hits	624	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SHE_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.182770 (rank : 25)
Query Neighborhood Hits	228	Target Neighborhood Hits	164	Shared Neighborhood Hits	57
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	1.06291 (rank : 95)	NC score	0.180703 (rank : 26)
Query Neighborhood Hits	228	Target Neighborhood Hits	169	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SRRM2_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.091654 (rank : 109)
Query Neighborhood Hits	228	Target Neighborhood Hits	1470	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SYNPO_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.058173 (rank : 253)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TAF6_HUMAN
θ value	1.06291 (rank : 98)	NC score	0.056162 (rank : 272)
Query Neighborhood Hits	228	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

TAF6_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.054058 (rank : 311)
Query Neighborhood Hits	228	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

DAPP1_HUMAN
θ value	1.38821 (rank : 100)	NC score	0.241282 (rank : 8)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

IF4B_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.052798 (rank : 349)
Query Neighborhood Hits	228	Target Neighborhood Hits	417	Shared Neighborhood Hits	34
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

ITK_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.106676 (rank : 77)
Query Neighborhood Hits	228	Target Neighborhood Hits	1016	Shared Neighborhood Hits	69
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

K0256_MOUSE
θ value	1.38821 (rank : 103)	NC score	0.033751 (rank : 458)
Query Neighborhood Hits	228	Target Neighborhood Hits	121	Shared Neighborhood Hits	10
SwissProt Accessions	Q6A098	Gene names	Kiaa0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

NOLC1_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.089934 (rank : 119)
Query Neighborhood Hits	228	Target Neighborhood Hits	452	Shared Neighborhood Hits	44
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PARM1_MOUSE
θ value	1.38821 (rank : 105)	NC score	0.053217 (rank : 335)
Query Neighborhood Hits	228	Target Neighborhood Hits	140	Shared Neighborhood Hits	17
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

VAV2_HUMAN
θ value	1.38821 (rank : 106)	NC score	0.144409 (rank : 38)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	60
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

AFF1_MOUSE
θ value	1.81305 (rank : 107)	NC score	0.078110 (rank : 158)
Query Neighborhood Hits	228	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CAH9_HUMAN
θ value	1.81305 (rank : 108)	NC score	0.014122 (rank : 503)
Query Neighborhood Hits	228	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	Q16790	Gene names	CA9, G250, MN
Domain Architecture
Description	Carbonic anhydrase 9 precursor (EC 4.2.1.1) (Carbonic anhydrase IX) (Carbonate dehydratase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC- associated antigen G250) (pMW1).

CJ012_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.081096 (rank : 151)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CO5A1_MOUSE
θ value	1.81305 (rank : 110)	NC score	0.015250 (rank : 499)
Query Neighborhood Hits	228	Target Neighborhood Hits	419	Shared Neighborhood Hits	23
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

ENL_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.075155 (rank : 171)
Query Neighborhood Hits	228	Target Neighborhood Hits	305	Shared Neighborhood Hits	36
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

IWS1_HUMAN
θ value	1.81305 (rank : 112)	NC score	0.082235 (rank : 149)
Query Neighborhood Hits	228	Target Neighborhood Hits	1241	Shared Neighborhood Hits	92
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KI13A_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.010239 (rank : 510)
Query Neighborhood Hits	228	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQW7, O35062	Gene names	Kif13a
Domain Architecture
Description	Kinesin-like protein KIF13A.

MUC5B_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.031653 (rank : 465)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

MYT1_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.030557 (rank : 468)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

PALM_HUMAN
θ value	1.81305 (rank : 116)	NC score	0.030464 (rank : 469)
Query Neighborhood Hits	228	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	O75781, O43359, O95673, Q92559, Q9UPJ4, Q9UQS2, Q9UQS3	Gene names	PALM, KIAA0270
Domain Architecture
Description	Paralemmin.

SHAN2_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.061384 (rank : 226)
Query Neighborhood Hits	228	Target Neighborhood Hits	346	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

ZO1_MOUSE
θ value	1.81305 (rank : 118)	NC score	0.034029 (rank : 457)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	27
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ANX11_HUMAN
θ value	2.36792 (rank : 119)	NC score	0.025718 (rank : 479)
Query Neighborhood Hits	228	Target Neighborhood Hits	192	Shared Neighborhood Hits	15
SwissProt Accessions	P50995	Gene names	ANXA11, ANX11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50) (56 kDa autoantigen).

BRD2_HUMAN
θ value	2.36792 (rank : 120)	NC score	0.040411 (rank : 445)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	14
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

BRD4_MOUSE
θ value	2.36792 (rank : 121)	NC score	0.071892 (rank : 182)
Query Neighborhood Hits	228	Target Neighborhood Hits	845	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

BRDT_HUMAN
θ value	2.36792 (rank : 122)	NC score	0.039739 (rank : 448)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	17
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

FGR_HUMAN
θ value	2.36792 (rank : 123)	NC score	0.104150 (rank : 82)
Query Neighborhood Hits	228	Target Neighborhood Hits	1067	Shared Neighborhood Hits	72
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GLU2B_MOUSE
θ value	2.36792 (rank : 124)	NC score	0.036623 (rank : 456)
Query Neighborhood Hits	228	Target Neighborhood Hits	357	Shared Neighborhood Hits	15
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

IASPP_MOUSE
θ value	2.36792 (rank : 125)	NC score	0.070294 (rank : 187)
Query Neighborhood Hits	228	Target Neighborhood Hits	1024	Shared Neighborhood Hits	67
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NKTR_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.028557 (rank : 472)
Query Neighborhood Hits	228	Target Neighborhood Hits	417	Shared Neighborhood Hits	25
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

ORC2_MOUSE
θ value	2.36792 (rank : 127)	NC score	0.032196 (rank : 461)
Query Neighborhood Hits	228	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q60862	Gene names	Orc2l, Orc2
Domain Architecture
Description	Origin recognition complex subunit 2.

OSBL8_HUMAN
θ value	2.36792 (rank : 128)	NC score	0.020577 (rank : 490)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

SF3A1_MOUSE
θ value	2.36792 (rank : 129)	NC score	0.075908 (rank : 168)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

SYT9_MOUSE
θ value	2.36792 (rank : 130)	NC score	0.011208 (rank : 506)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

WASL_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.098717 (rank : 94)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	33
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ASPP2_HUMAN
θ value	3.0926 (rank : 132)	NC score	0.052022 (rank : 368)
Query Neighborhood Hits	228	Target Neighborhood Hits	1156	Shared Neighborhood Hits	66
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ENAH_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.047994 (rank : 423)
Query Neighborhood Hits	228	Target Neighborhood Hits	919	Shared Neighborhood Hits	52
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

FGR_MOUSE
θ value	3.0926 (rank : 134)	NC score	0.105348 (rank : 80)
Query Neighborhood Hits	228	Target Neighborhood Hits	1069	Shared Neighborhood Hits	71
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

IF4B_MOUSE
θ value	3.0926 (rank : 135)	NC score	0.048231 (rank : 422)
Query Neighborhood Hits	228	Target Neighborhood Hits	368	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

K1219_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.047041 (rank : 426)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	14
SwissProt Accessions	Q86X10, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9	Gene names	KIAA1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

K1219_MOUSE
θ value	3.0926 (rank : 137)	NC score	0.042695 (rank : 435)
Query Neighborhood Hits	228	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BQZ4, Q80TH5, Q8BQN1	Gene names	Kiaa1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

LNK_HUMAN
θ value	3.0926 (rank : 138)	NC score	0.127629 (rank : 57)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LPP_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.042353 (rank : 436)
Query Neighborhood Hits	228	Target Neighborhood Hits	775	Shared Neighborhood Hits	59
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

M4K1_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.032158 (rank : 463)
Query Neighborhood Hits	228	Target Neighborhood Hits	884	Shared Neighborhood Hits	32
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MYO10_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.017920 (rank : 495)
Query Neighborhood Hits	228	Target Neighborhood Hits	920	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYT1L_HUMAN
θ value	3.0926 (rank : 142)	NC score	0.021490 (rank : 487)
Query Neighborhood Hits	228	Target Neighborhood Hits	471	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

NACAM_MOUSE
θ value	3.0926 (rank : 143)	NC score	0.100686 (rank : 90)
Query Neighborhood Hits	228	Target Neighborhood Hits	1866	Shared Neighborhood Hits	118
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NFM_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.020705 (rank : 489)
Query Neighborhood Hits	228	Target Neighborhood Hits	1328	Shared Neighborhood Hits	64
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

RGS3_HUMAN
θ value	3.0926 (rank : 145)	NC score	0.074212 (rank : 175)
Query Neighborhood Hits	228	Target Neighborhood Hits	1375	Shared Neighborhood Hits	96
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SET1A_HUMAN
θ value	3.0926 (rank : 146)	NC score	0.080621 (rank : 153)
Query Neighborhood Hits	228	Target Neighborhood Hits	690	Shared Neighborhood Hits	57
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SHC2_MOUSE
θ value	3.0926 (rank : 147)	NC score	0.173323 (rank : 27)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SRRM2_HUMAN
θ value	3.0926 (rank : 148)	NC score	0.090999 (rank : 112)
Query Neighborhood Hits	228	Target Neighborhood Hits	1296	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TTF2_MOUSE
θ value	3.0926 (rank : 149)	NC score	0.027935 (rank : 474)
Query Neighborhood Hits	228	Target Neighborhood Hits	364	Shared Neighborhood Hits	28
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

UBP42_HUMAN
θ value	3.0926 (rank : 150)	NC score	0.022703 (rank : 484)
Query Neighborhood Hits	228	Target Neighborhood Hits	445	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

ULK1_MOUSE
θ value	3.0926 (rank : 151)	NC score	0.043376 (rank : 432)
Query Neighborhood Hits	228	Target Neighborhood Hits	1214	Shared Neighborhood Hits	63
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

VAV2_MOUSE
θ value	3.0926 (rank : 152)	NC score	0.144058 (rank : 39)
Query Neighborhood Hits	228	Target Neighborhood Hits	456	Shared Neighborhood Hits	61
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ZC11A_HUMAN
θ value	3.0926 (rank : 153)	NC score	0.027840 (rank : 475)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	O75152, Q6AHY4, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7	Gene names	ZC3H11A, KIAA0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

BAZ2B_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.032941 (rank : 459)
Query Neighborhood Hits	228	Target Neighborhood Hits	803	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BCCIP_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.025360 (rank : 481)
Query Neighborhood Hits	228	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P287, Q8ND15, Q96GC4, Q9P288	Gene names	BCCIP, TOK1
Domain Architecture	No domain graphic available
Description	BRCA2 and CDKN1A-interacting protein (Protein TOK-1).

BLK_MOUSE
θ value	4.03905 (rank : 156)	NC score	0.090745 (rank : 113)
Query Neighborhood Hits	228	Target Neighborhood Hits	992	Shared Neighborhood Hits	66
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CK024_MOUSE
θ value	4.03905 (rank : 157)	NC score	0.040861 (rank : 444)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

GAB1_MOUSE
θ value	4.03905 (rank : 158)	NC score	0.059991 (rank : 237)
Query Neighborhood Hits	228	Target Neighborhood Hits	233	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GLU2B_HUMAN
θ value	4.03905 (rank : 159)	NC score	0.041152 (rank : 443)
Query Neighborhood Hits	228	Target Neighborhood Hits	377	Shared Neighborhood Hits	19
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

KAISO_MOUSE
θ value	4.03905 (rank : 160)	NC score	0.004227 (rank : 518)
Query Neighborhood Hits	228	Target Neighborhood Hits	821	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BN78, Q8C226, Q9WTZ7	Gene names	Zbtb33, Kaiso
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

LRP2_HUMAN
θ value	4.03905 (rank : 161)	NC score	0.004838 (rank : 517)
Query Neighborhood Hits	228	Target Neighborhood Hits	573	Shared Neighborhood Hits	7
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

MYLK_MOUSE
θ value	4.03905 (rank : 162)	NC score	0.037948 (rank : 452)
Query Neighborhood Hits	228	Target Neighborhood Hits	1489	Shared Neighborhood Hits	63
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

RGP1_MOUSE
θ value	4.03905 (rank : 163)	NC score	0.027411 (rank : 478)
Query Neighborhood Hits	228	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RHG25_MOUSE
θ value	4.03905 (rank : 164)	NC score	0.028428 (rank : 473)
Query Neighborhood Hits	228	Target Neighborhood Hits	492	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SETBP_HUMAN
θ value	4.03905 (rank : 165)	NC score	0.041335 (rank : 441)
Query Neighborhood Hits	228	Target Neighborhood Hits	305	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SH21B_MOUSE
θ value	4.03905 (rank : 166)	NC score	0.141447 (rank : 42)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TTLL5_HUMAN
θ value	4.03905 (rank : 167)	NC score	0.022334 (rank : 485)
Query Neighborhood Hits	228	Target Neighborhood Hits	141	Shared Neighborhood Hits	11
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

ZN750_MOUSE
θ value	4.03905 (rank : 168)	NC score	0.051216 (rank : 388)
Query Neighborhood Hits	228	Target Neighborhood Hits	346	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

ZO1_HUMAN
θ value	4.03905 (rank : 169)	NC score	0.042744 (rank : 433)
Query Neighborhood Hits	228	Target Neighborhood Hits	474	Shared Neighborhood Hits	37
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ACINU_MOUSE
θ value	5.27518 (rank : 170)	NC score	0.058503 (rank : 249)
Query Neighborhood Hits	228	Target Neighborhood Hits	712	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

CCDC9_HUMAN
θ value	5.27518 (rank : 171)	NC score	0.047697 (rank : 424)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

DLX2_HUMAN
θ value	5.27518 (rank : 172)	NC score	0.003656 (rank : 519)
Query Neighborhood Hits	228	Target Neighborhood Hits	355	Shared Neighborhood Hits	3
SwissProt Accessions	Q07687	Gene names	DLX2
Domain Architecture
Description	Homeobox protein DLX-2.

DMD_MOUSE
θ value	5.27518 (rank : 173)	NC score	0.005129 (rank : 516)
Query Neighborhood Hits	228	Target Neighborhood Hits	1111	Shared Neighborhood Hits	26
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DOCK4_HUMAN
θ value	5.27518 (rank : 174)	NC score	0.025649 (rank : 480)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

E2AK4_HUMAN
θ value	5.27518 (rank : 175)	NC score	0.029724 (rank : 471)
Query Neighborhood Hits	228	Target Neighborhood Hits	1012	Shared Neighborhood Hits	34
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

INVS_MOUSE
θ value	5.27518 (rank : 176)	NC score	0.014712 (rank : 501)
Query Neighborhood Hits	228	Target Neighborhood Hits	609	Shared Neighborhood Hits	32
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

KAISO_HUMAN
θ value	5.27518 (rank : 177)	NC score	0.003079 (rank : 522)
Query Neighborhood Hits	228	Target Neighborhood Hits	840	Shared Neighborhood Hits	15
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

MILK1_MOUSE
θ value	5.27518 (rank : 178)	NC score	0.046666 (rank : 428)
Query Neighborhood Hits	228	Target Neighborhood Hits	788	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NU214_HUMAN
θ value	5.27518 (rank : 179)	NC score	0.064029 (rank : 216)
Query Neighborhood Hits	228	Target Neighborhood Hits	657	Shared Neighborhood Hits	42
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

NUCL_HUMAN
θ value	5.27518 (rank : 180)	NC score	0.021673 (rank : 486)
Query Neighborhood Hits	228	Target Neighborhood Hits	415	Shared Neighborhood Hits	21
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

RFIP3_HUMAN
θ value	5.27518 (rank : 181)	NC score	0.020868 (rank : 488)
Query Neighborhood Hits	228	Target Neighborhood Hits	1055	Shared Neighborhood Hits	46
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

SH24A_HUMAN
θ value	5.27518 (rank : 182)	NC score	0.119895 (rank : 67)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SNP29_HUMAN
θ value	5.27518 (rank : 183)	NC score	0.043449 (rank : 431)
Query Neighborhood Hits	228	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	O95721	Gene names	SNAP29
Domain Architecture
Description	Synaptosomal-associated protein 29 (SNAP-29) (Vesicle-membrane fusion protein SNAP-29) (Soluble 29 kDa NSF attachment protein).

SON_HUMAN
θ value	5.27518 (rank : 184)	NC score	0.073442 (rank : 177)
Query Neighborhood Hits	228	Target Neighborhood Hits	1568	Shared Neighborhood Hits	91
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SOS2_HUMAN
θ value	5.27518 (rank : 185)	NC score	0.041536 (rank : 439)
Query Neighborhood Hits	228	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

TNNT2_HUMAN
θ value	5.27518 (rank : 186)	NC score	0.018388 (rank : 494)
Query Neighborhood Hits	228	Target Neighborhood Hits	433	Shared Neighborhood Hits	10
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TXND2_HUMAN
θ value	5.27518 (rank : 187)	NC score	0.085354 (rank : 136)
Query Neighborhood Hits	228	Target Neighborhood Hits	793	Shared Neighborhood Hits	78
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

USP9X_MOUSE
θ value	5.27518 (rank : 188)	NC score	0.010925 (rank : 508)
Query Neighborhood Hits	228	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

YLPM1_HUMAN
θ value	5.27518 (rank : 189)	NC score	0.066561 (rank : 204)
Query Neighborhood Hits	228	Target Neighborhood Hits	670	Shared Neighborhood Hits	51
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZF276_MOUSE
θ value	5.27518 (rank : 190)	NC score	0.000322 (rank : 524)
Query Neighborhood Hits	228	Target Neighborhood Hits	745	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CE64, Q9ESV2	Gene names	Zfp276
Domain Architecture	No domain graphic available
Description	Zinc finger protein 276 (Zfp-276).

ABI2_HUMAN
θ value	6.88961 (rank : 191)	NC score	0.064088 (rank : 215)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CCD1A_HUMAN
θ value	6.88961 (rank : 192)	NC score	0.041225 (rank : 442)
Query Neighborhood Hits	228	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P1N0, Q7Z435, Q86XV0, Q8NF89, Q9H603, Q9NXI1	Gene names	CC2D1A
Domain Architecture	No domain graphic available
Description	Coiled-coil and C2 domain-containing protein 1A (Five repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B- activating protein 023N).

DLX2_MOUSE
θ value	6.88961 (rank : 193)	NC score	0.003175 (rank : 521)
Query Neighborhood Hits	228	Target Neighborhood Hits	352	Shared Neighborhood Hits	3
SwissProt Accessions	P40764	Gene names	Dlx2, Tes-1, Tes1
Domain Architecture
Description	Homeobox protein DLX-2 (Homeobox protein TES-1).

ETV1_HUMAN
θ value	6.88961 (rank : 194)	NC score	0.006636 (rank : 513)
Query Neighborhood Hits	228	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

FBLN2_HUMAN
θ value	6.88961 (rank : 195)	NC score	0.003468 (rank : 520)
Query Neighborhood Hits	228	Target Neighborhood Hits	392	Shared Neighborhood Hits	12
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

HCLS1_HUMAN
θ value	6.88961 (rank : 196)	NC score	0.078916 (rank : 156)
Query Neighborhood Hits	228	Target Neighborhood Hits	358	Shared Neighborhood Hits	60
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

MAML1_HUMAN
θ value	6.88961 (rank : 197)	NC score	0.024511 (rank : 483)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MMP24_MOUSE
θ value	6.88961 (rank : 198)	NC score	0.008513 (rank : 512)
Query Neighborhood Hits	228	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

PAK4_MOUSE
θ value	6.88961 (rank : 199)	NC score	0.032171 (rank : 462)
Query Neighborhood Hits	228	Target Neighborhood Hits	1098	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PCLO_MOUSE
θ value	6.88961 (rank : 200)	NC score	0.065722 (rank : 207)
Query Neighborhood Hits	228	Target Neighborhood Hits	2275	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

REPS2_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.039357 (rank : 449)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SHC2_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.159472 (rank : 29)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	57
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

TNNT3_HUMAN
θ value	6.88961 (rank : 203)	NC score	0.013986 (rank : 504)
Query Neighborhood Hits	228	Target Neighborhood Hits	327	Shared Neighborhood Hits	8
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

TRI55_HUMAN
θ value	6.88961 (rank : 204)	NC score	0.006036 (rank : 515)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

TRUA_MOUSE
θ value	6.88961 (rank : 205)	NC score	0.015708 (rank : 498)
Query Neighborhood Hits	228	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WU56, Q8C250, Q8VDQ3	Gene names	Pus1
Domain Architecture
Description	tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I).

AB1IP_HUMAN
θ value	8.99809 (rank : 206)	NC score	0.050881 (rank : 396)
Query Neighborhood Hits	228	Target Neighborhood Hits	213	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

ATX7_MOUSE
θ value	8.99809 (rank : 207)	NC score	0.027759 (rank : 476)
Query Neighborhood Hits	228	Target Neighborhood Hits	328	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

BPTF_HUMAN
θ value	8.99809 (rank : 208)	NC score	0.046672 (rank : 427)
Query Neighborhood Hits	228	Target Neighborhood Hits	786	Shared Neighborhood Hits	44
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CCNH_MOUSE
θ value	8.99809 (rank : 209)	NC score	0.015922 (rank : 497)
Query Neighborhood Hits	228	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q61458, Q9CVJ0, Q9JHV7	Gene names	Ccnh
Domain Architecture
Description	Cyclin-H.

GAB2_MOUSE
θ value	8.99809 (rank : 210)	NC score	0.036921 (rank : 454)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GORS2_HUMAN
θ value	8.99809 (rank : 211)	NC score	0.014745 (rank : 500)
Query Neighborhood Hits	228	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

H6ST3_MOUSE
θ value	8.99809 (rank : 212)	NC score	0.009312 (rank : 511)
Query Neighborhood Hits	228	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYK4	Gene names	Hs6st3
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 3 (EC 2.8.2.-) (HS6ST-3) (mHS6ST- 3).

K0423_MOUSE
θ value	8.99809 (rank : 213)	NC score	0.010974 (rank : 507)
Query Neighborhood Hits	228	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

K1949_MOUSE
θ value	8.99809 (rank : 214)	NC score	0.042729 (rank : 434)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

MAP2_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.041746 (rank : 438)
Query Neighborhood Hits	228	Target Neighborhood Hits	348	Shared Neighborhood Hits	31
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

NALP1_HUMAN
θ value	8.99809 (rank : 216)	NC score	0.006173 (rank : 514)
Query Neighborhood Hits	228	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

PELP1_HUMAN
θ value	8.99809 (rank : 217)	NC score	0.051573 (rank : 380)
Query Neighborhood Hits	228	Target Neighborhood Hits	596	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

REXO1_MOUSE
θ value	8.99809 (rank : 218)	NC score	0.019896 (rank : 491)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

RFIP5_MOUSE
θ value	8.99809 (rank : 219)	NC score	0.025244 (rank : 482)
Query Neighborhood Hits	228	Target Neighborhood Hits	126	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

RTN1_MOUSE
θ value	8.99809 (rank : 220)	NC score	0.027418 (rank : 477)
Query Neighborhood Hits	228	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SYN2_MOUSE
θ value	8.99809 (rank : 221)	NC score	0.016927 (rank : 496)
Query Neighborhood Hits	228	Target Neighborhood Hits	183	Shared Neighborhood Hits	24
SwissProt Accessions	Q64332, Q6NZR0, Q9QWV7	Gene names	Syn2
Domain Architecture	No domain graphic available
Description	Synapsin-2 (Synapsin II).

TENS4_HUMAN
θ value	8.99809 (rank : 222)	NC score	0.071823 (rank : 183)
Query Neighborhood Hits	228	Target Neighborhood Hits	214	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TF3C2_MOUSE
θ value	8.99809 (rank : 223)	NC score	0.014530 (rank : 502)
Query Neighborhood Hits	228	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

TP53B_MOUSE
θ value	8.99809 (rank : 224)	NC score	0.057343 (rank : 262)
Query Neighborhood Hits	228	Target Neighborhood Hits	644	Shared Neighborhood Hits	68
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TTBK1_HUMAN
θ value	8.99809 (rank : 225)	NC score	0.038685 (rank : 451)
Query Neighborhood Hits	228	Target Neighborhood Hits	1058	Shared Neighborhood Hits	52
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTLL5_MOUSE
θ value	8.99809 (rank : 226)	NC score	0.018761 (rank : 493)
Query Neighborhood Hits	228	Target Neighborhood Hits	150	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

ZEP2_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.010632 (rank : 509)
Query Neighborhood Hits	228	Target Neighborhood Hits	937	Shared Neighborhood Hits	30
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ZEP2_MOUSE
θ value	8.99809 (rank : 228)	NC score	0.011619 (rank : 505)
Query Neighborhood Hits	228	Target Neighborhood Hits	964	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

AATK_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.062143 (rank : 223)
Query Neighborhood Hits	228	Target Neighborhood Hits	1243	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.061971 (rank : 225)
Query Neighborhood Hits	228	Target Neighborhood Hits	942	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.050277 (rank : 413)
Query Neighborhood Hits	228	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI2_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.053887 (rank : 316)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	37
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ACK1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.063923 (rank : 217)
Query Neighborhood Hits	228	Target Neighborhood Hits	1140	Shared Neighborhood Hits	75
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.062956 (rank : 219)
Query Neighborhood Hits	228	Target Neighborhood Hits	1080	Shared Neighborhood Hits	62
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AHI1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.054194 (rank : 308)
Query Neighborhood Hits	228	Target Neighborhood Hits	537	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.054222 (rank : 307)
Query Neighborhood Hits	228	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALK_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.058560 (rank : 248)
Query Neighborhood Hits	228	Target Neighborhood Hits	795	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.058830 (rank : 245)
Query Neighborhood Hits	228	Target Neighborhood Hits	811	Shared Neighborhood Hits	31
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

APS_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.118572 (rank : 69)
Query Neighborhood Hits	228	Target Neighborhood Hits	162	Shared Neighborhood Hits	50
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.102669 (rank : 84)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG6_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.053842 (rank : 321)
Query Neighborhood Hits	228	Target Neighborhood Hits	376	Shared Neighborhood Hits	34
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.050079 (rank : 417)
Query Neighborhood Hits	228	Target Neighborhood Hits	394	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.051636 (rank : 375)
Query Neighborhood Hits	228	Target Neighborhood Hits	347	Shared Neighborhood Hits	32
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.054183 (rank : 309)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ASPP1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.060722 (rank : 233)
Query Neighborhood Hits	228	Target Neighborhood Hits	1244	Shared Neighborhood Hits	86
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAG3_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.055244 (rank : 290)
Query Neighborhood Hits	228	Target Neighborhood Hits	513	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BASP_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.068600 (rank : 193)
Query Neighborhood Hits	228	Target Neighborhood Hits	321	Shared Neighborhood Hits	31
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BAT2_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.052731 (rank : 354)
Query Neighborhood Hits	228	Target Neighborhood Hits	947	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BCAR1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.058592 (rank : 247)
Query Neighborhood Hits	228	Target Neighborhood Hits	554	Shared Neighborhood Hits	71
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR3_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.084787 (rank : 138)
Query Neighborhood Hits	228	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.082458 (rank : 147)
Query Neighborhood Hits	228	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCL9_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.060968 (rank : 228)
Query Neighborhood Hits	228	Target Neighborhood Hits	1008	Shared Neighborhood Hits	63
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BLK_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.086535 (rank : 134)
Query Neighborhood Hits	228	Target Neighborhood Hits	994	Shared Neighborhood Hits	66
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BSN_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.053370 (rank : 332)
Query Neighborhood Hits	228	Target Neighborhood Hits	1537	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CBP_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.050170 (rank : 416)
Query Neighborhood Hits	228	Target Neighborhood Hits	1051	Shared Neighborhood Hits	70
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CD2AP_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.060670 (rank : 234)
Query Neighborhood Hits	228	Target Neighborhood Hits	315	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.071119 (rank : 185)
Query Neighborhood Hits	228	Target Neighborhood Hits	336	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHIN_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.056485 (rank : 269)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.058204 (rank : 252)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	41
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.050262 (rank : 414)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	38
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.051556 (rank : 381)
Query Neighborhood Hits	228	Target Neighborhood Hits	374	Shared Neighborhood Hits	36
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CISH_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.077262 (rank : 159)
Query Neighborhood Hits	228	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.077020 (rank : 161)
Query Neighborhood Hits	228	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CRKL_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.146892 (rank : 36)
Query Neighborhood Hits	228	Target Neighborhood Hits	313	Shared Neighborhood Hits	56
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.152690 (rank : 34)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	57
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.140923 (rank : 44)
Query Neighborhood Hits	228	Target Neighborhood Hits	308	Shared Neighborhood Hits	58
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.139564 (rank : 46)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	59
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CSF1R_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.053113 (rank : 339)
Query Neighborhood Hits	228	Target Neighborhood Hits	943	Shared Neighborhood Hits	28
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.052732 (rank : 352)
Query Neighborhood Hits	228	Target Neighborhood Hits	983	Shared Neighborhood Hits	28
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSK_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.090275 (rank : 114)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	65
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.089999 (rank : 118)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	65
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DBNL_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.056816 (rank : 266)
Query Neighborhood Hits	228	Target Neighborhood Hits	244	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.055630 (rank : 279)
Query Neighborhood Hits	228	Target Neighborhood Hits	306	Shared Neighborhood Hits	35
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDR1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.055528 (rank : 283)
Query Neighborhood Hits	228	Target Neighborhood Hits	819	Shared Neighborhood Hits	29
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.055552 (rank : 282)
Query Neighborhood Hits	228	Target Neighborhood Hits	818	Shared Neighborhood Hits	30
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.054270 (rank : 304)
Query Neighborhood Hits	228	Target Neighborhood Hits	818	Shared Neighborhood Hits	27
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.054050 (rank : 312)
Query Neighborhood Hits	228	Target Neighborhood Hits	813	Shared Neighborhood Hits	27
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DNMBP_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.060529 (rank : 235)
Query Neighborhood Hits	228	Target Neighborhood Hits	413	Shared Neighborhood Hits	42
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.062234 (rank : 222)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	56
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ECM1_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.060850 (rank : 231)
Query Neighborhood Hits	228	Target Neighborhood Hits	105	Shared Neighborhood Hits	20
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

EFS_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.059263 (rank : 242)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EGFR_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.052845 (rank : 345)
Query Neighborhood Hits	228	Target Neighborhood Hits	939	Shared Neighborhood Hits	32
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.052824 (rank : 347)
Query Neighborhood Hits	228	Target Neighborhood Hits	927	Shared Neighborhood Hits	31
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.051187 (rank : 389)
Query Neighborhood Hits	228	Target Neighborhood Hits	997	Shared Neighborhood Hits	27
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.051303 (rank : 386)
Query Neighborhood Hits	228	Target Neighborhood Hits	958	Shared Neighborhood Hits	30
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.052693 (rank : 357)
Query Neighborhood Hits	228	Target Neighborhood Hits	1021	Shared Neighborhood Hits	31
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.052765 (rank : 350)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	32
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.050754 (rank : 399)
Query Neighborhood Hits	228	Target Neighborhood Hits	1005	Shared Neighborhood Hits	30
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.050830 (rank : 397)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	30
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.050532 (rank : 403)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	28
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.050528 (rank : 405)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	28
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.051617 (rank : 377)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	33
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.053255 (rank : 333)
Query Neighborhood Hits	228	Target Neighborhood Hits	950	Shared Neighborhood Hits	31
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.053512 (rank : 328)
Query Neighborhood Hits	228	Target Neighborhood Hits	959	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.053476 (rank : 330)
Query Neighborhood Hits	228	Target Neighborhood Hits	946	Shared Neighborhood Hits	30
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.050078 (rank : 418)
Query Neighborhood Hits	228	Target Neighborhood Hits	1053	Shared Neighborhood Hits	32
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.050056 (rank : 420)
Query Neighborhood Hits	228	Target Neighborhood Hits	1025	Shared Neighborhood Hits	32
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.051477 (rank : 383)
Query Neighborhood Hits	228	Target Neighborhood Hits	956	Shared Neighborhood Hits	29
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.051872 (rank : 372)
Query Neighborhood Hits	228	Target Neighborhood Hits	969	Shared Neighborhood Hits	30
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.052838 (rank : 346)
Query Neighborhood Hits	228	Target Neighborhood Hits	960	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.051122 (rank : 390)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	31
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.051412 (rank : 385)
Query Neighborhood Hits	228	Target Neighborhood Hits	983	Shared Neighborhood Hits	32
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.051449 (rank : 384)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	32
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.052731 (rank : 353)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	31
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.052807 (rank : 348)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	32
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.051575 (rank : 379)
Query Neighborhood Hits	228	Target Neighborhood Hits	1056	Shared Neighborhood Hits	33
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.051629 (rank : 376)
Query Neighborhood Hits	228	Target Neighborhood Hits	1013	Shared Neighborhood Hits	32
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.053529 (rank : 326)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	29
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.053009 (rank : 341)
Query Neighborhood Hits	228	Target Neighborhood Hits	906	Shared Neighborhood Hits	28
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.057108 (rank : 264)
Query Neighborhood Hits	228	Target Neighborhood Hits	1073	Shared Neighborhood Hits	48
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.054243 (rank : 305)
Query Neighborhood Hits	228	Target Neighborhood Hits	918	Shared Neighborhood Hits	32
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.053525 (rank : 327)
Query Neighborhood Hits	228	Target Neighborhood Hits	918	Shared Neighborhood Hits	27
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.053492 (rank : 329)
Query Neighborhood Hits	228	Target Neighborhood Hits	898	Shared Neighborhood Hits	30
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.054393 (rank : 302)
Query Neighborhood Hits	228	Target Neighborhood Hits	910	Shared Neighborhood Hits	28
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L3_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.057775 (rank : 258)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FA47A_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.066902 (rank : 201)
Query Neighborhood Hits	228	Target Neighborhood Hits	451	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FA47B_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.060889 (rank : 229)
Query Neighborhood Hits	228	Target Neighborhood Hits	431	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FAK1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.052277 (rank : 360)
Query Neighborhood Hits	228	Target Neighborhood Hits	850	Shared Neighborhood Hits	30
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.052489 (rank : 359)
Query Neighborhood Hits	228	Target Neighborhood Hits	850	Shared Neighborhood Hits	31
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.054737 (rank : 294)
Query Neighborhood Hits	228	Target Neighborhood Hits	847	Shared Neighborhood Hits	27
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.054462 (rank : 299)
Query Neighborhood Hits	228	Target Neighborhood Hits	851	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FES_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.067607 (rank : 197)
Query Neighborhood Hits	228	Target Neighborhood Hits	978	Shared Neighborhood Hits	53
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.064148 (rank : 214)
Query Neighborhood Hits	228	Target Neighborhood Hits	980	Shared Neighborhood Hits	47
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.050343 (rank : 410)
Query Neighborhood Hits	228	Target Neighborhood Hits	1069	Shared Neighborhood Hits	28
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.050388 (rank : 409)
Query Neighborhood Hits	228	Target Neighborhood Hits	1068	Shared Neighborhood Hits	28
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.050335 (rank : 411)
Query Neighborhood Hits	228	Target Neighborhood Hits	1062	Shared Neighborhood Hits	28
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.050514 (rank : 406)
Query Neighborhood Hits	228	Target Neighborhood Hits	1062	Shared Neighborhood Hits	28
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.050914 (rank : 395)
Query Neighborhood Hits	228	Target Neighborhood Hits	1042	Shared Neighborhood Hits	28
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.050962 (rank : 394)
Query Neighborhood Hits	228	Target Neighborhood Hits	1059	Shared Neighborhood Hits	28
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.051538 (rank : 382)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	30
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.052265 (rank : 361)
Query Neighborhood Hits	228	Target Neighborhood Hits	1026	Shared Neighborhood Hits	29
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.053855 (rank : 319)
Query Neighborhood Hits	228	Target Neighborhood Hits	843	Shared Neighborhood Hits	28
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.055321 (rank : 288)
Query Neighborhood Hits	228	Target Neighborhood Hits	847	Shared Neighborhood Hits	28
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FYB_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.055790 (rank : 278)
Query Neighborhood Hits	228	Target Neighborhood Hits	379	Shared Neighborhood Hits	44
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

FYN_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.094057 (rank : 104)
Query Neighborhood Hits	228	Target Neighborhood Hits	1078	Shared Neighborhood Hits	69
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.094672 (rank : 103)
Query Neighborhood Hits	228	Target Neighborhood Hits	1073	Shared Neighborhood Hits	68
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAB1_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.060493 (rank : 236)
Query Neighborhood Hits	228	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GGN_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.055588 (rank : 280)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRAP2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.154030 (rank : 33)
Query Neighborhood Hits	228	Target Neighborhood Hits	304	Shared Neighborhood Hits	58
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.154105 (rank : 32)
Query Neighborhood Hits	228	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB10_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.066462 (rank : 205)
Query Neighborhood Hits	228	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.066877 (rank : 202)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.088927 (rank : 126)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.095966 (rank : 100)
Query Neighborhood Hits	228	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.078562 (rank : 157)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.083357 (rank : 144)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HCK_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.091633 (rank : 110)
Query Neighborhood Hits	228	Target Neighborhood Hits	1035	Shared Neighborhood Hits	68
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.091557 (rank : 111)
Query Neighborhood Hits	228	Target Neighborhood Hits	1029	Shared Neighborhood Hits	66
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCLS1_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.074827 (rank : 172)
Query Neighborhood Hits	228	Target Neighborhood Hits	329	Shared Neighborhood Hits	53
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HRX_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.065749 (rank : 206)
Query Neighborhood Hits	228	Target Neighborhood Hits	825	Shared Neighborhood Hits	59
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

HSH2D_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.096708 (rank : 98)
Query Neighborhood Hits	228	Target Neighborhood Hits	159	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.092208 (rank : 108)
Query Neighborhood Hits	228	Target Neighborhood Hits	124	Shared Neighborhood Hits	41
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.058413 (rank : 250)
Query Neighborhood Hits	228	Target Neighborhood Hits	688	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IGF1R_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.054784 (rank : 292)
Query Neighborhood Hits	228	Target Neighborhood Hits	977	Shared Neighborhood Hits	32
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.054490 (rank : 298)
Query Neighborhood Hits	228	Target Neighborhood Hits	973	Shared Neighborhood Hits	31
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.054750 (rank : 293)
Query Neighborhood Hits	228	Target Neighborhood Hits	950	Shared Neighborhood Hits	32
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.054227 (rank : 306)
Query Neighborhood Hits	228	Target Neighborhood Hits	961	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.053401 (rank : 331)
Query Neighborhood Hits	228	Target Neighborhood Hits	963	Shared Neighborhood Hits	30
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.052848 (rank : 344)
Query Neighborhood Hits	228	Target Neighborhood Hits	968	Shared Neighborhood Hits	30
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ITSN1_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.060798 (rank : 232)
Query Neighborhood Hits	228	Target Neighborhood Hits	1757	Shared Neighborhood Hits	95
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.058964 (rank : 243)
Query Neighborhood Hits	228	Target Neighborhood Hits	1669	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.053661 (rank : 324)
Query Neighborhood Hits	228	Target Neighborhood Hits	1173	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.052255 (rank : 362)
Query Neighborhood Hits	228	Target Neighborhood Hits	1371	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

IWS1_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.076855 (rank : 163)
Query Neighborhood Hits	228	Target Neighborhood Hits	1258	Shared Neighborhood Hits	83
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K1543_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.062944 (rank : 220)
Query Neighborhood Hits	228	Target Neighborhood Hits	497	Shared Neighborhood Hits	51
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1802_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.051746 (rank : 373)
Query Neighborhood Hits	228	Target Neighborhood Hits	1596	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

KIT_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.051609 (rank : 378)
Query Neighborhood Hits	228	Target Neighborhood Hits	953	Shared Neighborhood Hits	28
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.052184 (rank : 366)
Query Neighborhood Hits	228	Target Neighborhood Hits	949	Shared Neighborhood Hits	28
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSYK_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.076586 (rank : 164)
Query Neighborhood Hits	228	Target Neighborhood Hits	901	Shared Neighborhood Hits	60
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.076960 (rank : 162)
Query Neighborhood Hits	228	Target Neighborhood Hits	944	Shared Neighborhood Hits	63
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAD1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.073219 (rank : 178)
Query Neighborhood Hits	228	Target Neighborhood Hits	391	Shared Neighborhood Hits	45
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LCK_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.088306 (rank : 128)
Query Neighborhood Hits	228	Target Neighborhood Hits	987	Shared Neighborhood Hits	64
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.087475 (rank : 132)
Query Neighborhood Hits	228	Target Neighborhood Hits	981	Shared Neighborhood Hits	63
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LTK_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.059557 (rank : 241)
Query Neighborhood Hits	228	Target Neighborhood Hits	774	Shared Neighborhood Hits	27
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.059709 (rank : 240)
Query Neighborhood Hits	228	Target Neighborhood Hits	770	Shared Neighborhood Hits	28
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LYN_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.089159 (rank : 124)
Query Neighborhood Hits	228	Target Neighborhood Hits	1022	Shared Neighborhood Hits	68
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.089406 (rank : 122)
Query Neighborhood Hits	228	Target Neighborhood Hits	1023	Shared Neighborhood Hits	68
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.050710 (rank : 401)
Query Neighborhood Hits	228	Target Neighborhood Hits	1071	Shared Neighborhood Hits	50
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.056043 (rank : 275)
Query Neighborhood Hits	228	Target Neighborhood Hits	1136	Shared Neighborhood Hits	60
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.052592 (rank : 358)
Query Neighborhood Hits	228	Target Neighborhood Hits	1123	Shared Neighborhood Hits	60
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.052707 (rank : 355)
Query Neighborhood Hits	228	Target Neighborhood Hits	1087	Shared Neighborhood Hits	48
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAGE1_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.057524 (rank : 260)
Query Neighborhood Hits	228	Target Neighborhood Hits	1389	Shared Neighborhood Hits	92
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAP4_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.057889 (rank : 257)
Query Neighborhood Hits	228	Target Neighborhood Hits	428	Shared Neighborhood Hits	51
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MATK_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.083896 (rank : 140)
Query Neighborhood Hits	228	Target Neighborhood Hits	954	Shared Neighborhood Hits	62
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.083016 (rank : 146)
Query Neighborhood Hits	228	Target Neighborhood Hits	952	Shared Neighborhood Hits	62
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MDC1_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.076033 (rank : 167)
Query Neighborhood Hits	228	Target Neighborhood Hits	1446	Shared Neighborhood Hits	99
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.076294 (rank : 165)
Query Neighborhood Hits	228	Target Neighborhood Hits	998	Shared Neighborhood Hits	87
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MERTK_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.056066 (rank : 274)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	30
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.055327 (rank : 287)
Query Neighborhood Hits	228	Target Neighborhood Hits	974	Shared Neighborhood Hits	29
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.051901 (rank : 370)
Query Neighborhood Hits	228	Target Neighborhood Hits	831	Shared Neighborhood Hits	26
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.052248 (rank : 363)
Query Neighborhood Hits	228	Target Neighborhood Hits	844	Shared Neighborhood Hits	26
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLL3_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.068079 (rank : 194)
Query Neighborhood Hits	228	Target Neighborhood Hits	1399	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MUC1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.053883 (rank : 317)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	65
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MUSK_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.053852 (rank : 320)
Query Neighborhood Hits	228	Target Neighborhood Hits	1074	Shared Neighborhood Hits	28
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.054100 (rank : 310)
Query Neighborhood Hits	228	Target Neighborhood Hits	1057	Shared Neighborhood Hits	28
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NCF1_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.050981 (rank : 392)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF2_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.052187 (rank : 365)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	28
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCOA6_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.064482 (rank : 210)
Query Neighborhood Hits	228	Target Neighborhood Hits	1202	Shared Neighborhood Hits	90
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NFH_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.062053 (rank : 224)
Query Neighborhood Hits	228	Target Neighborhood Hits	2247	Shared Neighborhood Hits	115
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NPHP1_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.074214 (rank : 174)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	31
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.080678 (rank : 152)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NTRK1_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.056157 (rank : 273)
Query Neighborhood Hits	228	Target Neighborhood Hits	1023	Shared Neighborhood Hits	29
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.054413 (rank : 301)
Query Neighborhood Hits	228	Target Neighborhood Hits	1081	Shared Neighborhood Hits	29
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.054414 (rank : 300)
Query Neighborhood Hits	228	Target Neighborhood Hits	1088	Shared Neighborhood Hits	29
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.056732 (rank : 267)
Query Neighborhood Hits	228	Target Neighborhood Hits	1115	Shared Neighborhood Hits	29
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OGFR_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.051892 (rank : 371)
Query Neighborhood Hits	228	Target Neighborhood Hits	1582	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OSTF1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.057997 (rank : 256)
Query Neighborhood Hits	228	Target Neighborhood Hits	466	Shared Neighborhood Hits	31
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.055581 (rank : 281)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	31
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.050032 (rank : 421)
Query Neighborhood Hits	228	Target Neighborhood Hits	339	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PGFRA_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.053191 (rank : 337)
Query Neighborhood Hits	228	Target Neighborhood Hits	980	Shared Neighborhood Hits	28
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.052912 (rank : 343)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	28
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.053758 (rank : 323)
Query Neighborhood Hits	228	Target Neighborhood Hits	962	Shared Neighborhood Hits	28
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.053951 (rank : 315)
Query Neighborhood Hits	228	Target Neighborhood Hits	960	Shared Neighborhood Hits	28
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PPIP1_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.064248 (rank : 213)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.059839 (rank : 239)
Query Neighborhood Hits	228	Target Neighborhood Hits	377	Shared Neighborhood Hits	42
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.096283 (rank : 99)
Query Neighborhood Hits	228	Target Neighborhood Hits	330	Shared Neighborhood Hits	37
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRG4_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.075561 (rank : 170)
Query Neighborhood Hits	228	Target Neighborhood Hits	764	Shared Neighborhood Hits	70
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.060865 (rank : 230)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRRT3_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.080619 (rank : 154)
Query Neighborhood Hits	228	Target Neighborhood Hits	998	Shared Neighborhood Hits	83
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTK6_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.083461 (rank : 143)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	63
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.089040 (rank : 125)
Query Neighborhood Hits	228	Target Neighborhood Hits	1026	Shared Neighborhood Hits	65
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.053978 (rank : 314)
Query Neighborhood Hits	228	Target Neighborhood Hits	1103	Shared Neighborhood Hits	28
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN6_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.089212 (rank : 123)
Query Neighborhood Hits	228	Target Neighborhood Hits	234	Shared Neighborhood Hits	55
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.092467 (rank : 107)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RAPH1_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.058307 (rank : 251)
Query Neighborhood Hits	228	Target Neighborhood Hits	593	Shared Neighborhood Hits	59
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA2_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.057477 (rank : 261)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	18
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.058736 (rank : 246)
Query Neighborhood Hits	228	Target Neighborhood Hits	159	Shared Neighborhood Hits	20
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.055235 (rank : 291)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.055257 (rank : 289)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RET_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.050972 (rank : 393)
Query Neighborhood Hits	228	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.050418 (rank : 408)
Query Neighborhood Hits	228	Target Neighborhood Hits	884	Shared Neighborhood Hits	26
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RGS3_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.069600 (rank : 190)
Query Neighborhood Hits	228	Target Neighborhood Hits	1621	Shared Neighborhood Hits	105
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RON_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.051665 (rank : 374)
Query Neighborhood Hits	228	Target Neighborhood Hits	842	Shared Neighborhood Hits	26
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.052151 (rank : 367)
Query Neighborhood Hits	228	Target Neighborhood Hits	836	Shared Neighborhood Hits	25
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.052742 (rank : 351)
Query Neighborhood Hits	228	Target Neighborhood Hits	1018	Shared Neighborhood Hits	28
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.052978 (rank : 342)
Query Neighborhood Hits	228	Target Neighborhood Hits	1025	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.052698 (rank : 356)
Query Neighborhood Hits	228	Target Neighborhood Hits	1014	Shared Neighborhood Hits	30
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.054002 (rank : 313)
Query Neighborhood Hits	228	Target Neighborhood Hits	1000	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.056934 (rank : 265)
Query Neighborhood Hits	228	Target Neighborhood Hits	907	Shared Neighborhood Hits	31
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RYK_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.055888 (rank : 277)
Query Neighborhood Hits	228	Target Neighborhood Hits	701	Shared Neighborhood Hits	26
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.055469 (rank : 285)
Query Neighborhood Hits	228	Target Neighborhood Hits	715	Shared Neighborhood Hits	26
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SH21A_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.139802 (rank : 45)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.150540 (rank : 35)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.144040 (rank : 40)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.071780 (rank : 184)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.079063 (rank : 155)
Query Neighborhood Hits	228	Target Neighborhood Hits	179	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.093922 (rank : 105)
Query Neighborhood Hits	228	Target Neighborhood Hits	149	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.081907 (rank : 150)
Query Neighborhood Hits	228	Target Neighborhood Hits	326	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.090113 (rank : 116)
Query Neighborhood Hits	228	Target Neighborhood Hits	188	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.089874 (rank : 121)
Query Neighborhood Hits	228	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3K1_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.067152 (rank : 199)
Query Neighborhood Hits	228	Target Neighborhood Hits	341	Shared Neighborhood Hits	38
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.064327 (rank : 212)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHB_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.132756 (rank : 51)
Query Neighborhood Hits	228	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.135449 (rank : 49)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.145322 (rank : 37)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.155478 (rank : 31)
Query Neighborhood Hits	228	Target Neighborhood Hits	180	Shared Neighborhood Hits	59
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.121603 (rank : 66)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	55
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.125318 (rank : 64)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SLAP1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.128095 (rank : 56)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.127570 (rank : 58)
Query Neighborhood Hits	228	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.134219 (rank : 50)
Query Neighborhood Hits	228	Target Neighborhood Hits	139	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.143946 (rank : 41)
Query Neighborhood Hits	228	Target Neighborhood Hits	136	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS2_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.097161 (rank : 96)
Query Neighborhood Hits	228	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.102185 (rank : 88)
Query Neighborhood Hits	228	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS3_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.050280 (rank : 412)
Query Neighborhood Hits	228	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.050672 (rank : 402)
Query Neighborhood Hits	228	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS6_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.082307 (rank : 148)
Query Neighborhood Hits	228	Target Neighborhood Hits	126	Shared Neighborhood Hits	35
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.083337 (rank : 145)
Query Neighborhood Hits	228	Target Neighborhood Hits	146	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.084833 (rank : 137)
Query Neighborhood Hits	228	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SON_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.056200 (rank : 271)
Query Neighborhood Hits	228	Target Neighborhood Hits	957	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SPN90_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.058172 (rank : 254)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.054517 (rank : 297)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRBS1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.069897 (rank : 189)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.074438 (rank : 173)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	56
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.055487 (rank : 284)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	39
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.052197 (rank : 364)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.097227 (rank : 95)
Query Neighborhood Hits	228	Target Neighborhood Hits	1058	Shared Neighborhood Hits	69
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.096780 (rank : 97)
Query Neighborhood Hits	228	Target Neighborhood Hits	1033	Shared Neighborhood Hits	69
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRMS_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.083856 (rank : 141)
Query Neighborhood Hits	228	Target Neighborhood Hits	946	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.084509 (rank : 139)
Query Neighborhood Hits	228	Target Neighborhood Hits	964	Shared Neighborhood Hits	61
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRRM1_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.099400 (rank : 93)
Query Neighborhood Hits	228	Target Neighborhood Hits	690	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.107458 (rank : 76)
Query Neighborhood Hits	228	Target Neighborhood Hits	966	Shared Neighborhood Hits	82
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STAC3_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.057318 (rank : 263)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	30
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.055360 (rank : 286)
Query Neighborhood Hits	228	Target Neighborhood Hits	232	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.061291 (rank : 227)
Query Neighborhood Hits	228	Target Neighborhood Hits	276	Shared Neighborhood Hits	33
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.065488 (rank : 208)
Query Neighborhood Hits	228	Target Neighborhood Hits	268	Shared Neighborhood Hits	30
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.069217 (rank : 191)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.070242 (rank : 188)
Query Neighborhood Hits	228	Target Neighborhood Hits	273	Shared Neighborhood Hits	35
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.070471 (rank : 186)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	39
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.072029 (rank : 181)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	35
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.058127 (rank : 255)
Query Neighborhood Hits	228	Target Neighborhood Hits	786	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.056586 (rank : 268)
Query Neighborhood Hits	228	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TARA_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.056253 (rank : 270)
Query Neighborhood Hits	228	Target Neighborhood Hits	1626	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARSH_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.073667 (rank : 176)
Query Neighborhood Hits	228	Target Neighborhood Hits	768	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.090016 (rank : 117)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.053205 (rank : 336)
Query Neighborhood Hits	228	Target Neighborhood Hits	1103	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.050064 (rank : 419)
Query Neighborhood Hits	228	Target Neighborhood Hits	1333	Shared Neighborhood Hits	49
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGON2_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.057600 (rank : 259)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	72
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TIE1_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.050531 (rank : 404)
Query Neighborhood Hits	228	Target Neighborhood Hits	1241	Shared Neighborhood Hits	32
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.050772 (rank : 398)
Query Neighborhood Hits	228	Target Neighborhood Hits	1266	Shared Neighborhood Hits	33
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.051047 (rank : 391)
Query Neighborhood Hits	228	Target Neighborhood Hits	1192	Shared Neighborhood Hits	34
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.050459 (rank : 407)
Query Neighborhood Hits	228	Target Neighborhood Hits	1204	Shared Neighborhood Hits	31
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNK1_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.054606 (rank : 296)
Query Neighborhood Hits	228	Target Neighborhood Hits	815	Shared Neighborhood Hits	32
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.053587 (rank : 325)
Query Neighborhood Hits	228	Target Neighborhood Hits	806	Shared Neighborhood Hits	32
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TYRO3_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.053097 (rank : 340)
Query Neighborhood Hits	228	Target Neighborhood Hits	995	Shared Neighborhood Hits	28
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.053165 (rank : 338)
Query Neighborhood Hits	228	Target Neighborhood Hits	1007	Shared Neighborhood Hits	29
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.054359 (rank : 303)
Query Neighborhood Hits	228	Target Neighborhood Hits	981	Shared Neighborhood Hits	31
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.053856 (rank : 318)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	32
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VAV_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.130041 (rank : 54)
Query Neighborhood Hits	228	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.125401 (rank : 63)
Query Neighborhood Hits	228	Target Neighborhood Hits	430	Shared Neighborhood Hits	53
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VGFR3_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.050242 (rank : 415)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	28
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.050748 (rank : 400)
Query Neighborhood Hits	228	Target Neighborhood Hits	1056	Shared Neighborhood Hits	28
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VINEX_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.062419 (rank : 221)
Query Neighborhood Hits	228	Target Neighborhood Hits	270	Shared Neighborhood Hits	36
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.067514 (rank : 198)
Query Neighborhood Hits	228	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WASF2_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.059877 (rank : 238)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WASF2_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.063719 (rank : 218)
Query Neighborhood Hits	228	Target Neighborhood Hits	315	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WASF4_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.067616 (rank : 196)
Query Neighborhood Hits	228	Target Neighborhood Hits	282	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

WASIP_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.093534 (rank : 106)
Query Neighborhood Hits	228	Target Neighborhood Hits	458	Shared Neighborhood Hits	42
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.064987 (rank : 209)
Query Neighborhood Hits	228	Target Neighborhood Hits	392	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WASP_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.053233 (rank : 334)
Query Neighborhood Hits	228	Target Neighborhood Hits	195	Shared Neighborhood Hits	21
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

YES_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.094894 (rank : 101)
Query Neighborhood Hits	228	Target Neighborhood Hits	1059	Shared Neighborhood Hits	68
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.094838 (rank : 102)
Query Neighborhood Hits	228	Target Neighborhood Hits	1052	Shared Neighborhood Hits	67
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.075811 (rank : 169)
Query Neighborhood Hits	228	Target Neighborhood Hits	893	Shared Neighborhood Hits	63
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.077244 (rank : 160)
Query Neighborhood Hits	228	Target Neighborhood Hits	905	Shared Neighborhood Hits	64
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

BLNK_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
NC score	0.909692 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	228	Target Neighborhood Hits	296	Shared Neighborhood Hits	132
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

LCP2_MOUSE
NC score	0.589905 (rank : 3)	θ value	6.20254e-17 (rank : 4)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	57
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_HUMAN
NC score	0.551823 (rank : 4)	θ value	8.08199e-25 (rank : 3)
Query Neighborhood Hits	228	Target Neighborhood Hits	531	Shared Neighborhood Hits	96
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

P85B_MOUSE
NC score	0.246567 (rank : 5)	θ value	0.0113563 (rank : 20)
Query Neighborhood Hits	228	Target Neighborhood Hits	519	Shared Neighborhood Hits	64
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_HUMAN
NC score	0.246352 (rank : 6)	θ value	0.0113563 (rank : 19)
Query Neighborhood Hits	228	Target Neighborhood Hits	543	Shared Neighborhood Hits	69
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

NCK1_HUMAN
NC score	0.242494 (rank : 7)	θ value	0.00509761 (rank : 18)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

DAPP1_HUMAN
NC score	0.241282 (rank : 8)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.240809 (rank : 9)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GRAP_MOUSE
NC score	0.240359 (rank : 10)	θ value	0.00228821 (rank : 13)
Query Neighborhood Hits	228	Target Neighborhood Hits	309	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.237926 (rank : 11)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	62
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PLCG2_HUMAN
NC score	0.236128 (rank : 12)	θ value	0.000786445 (rank : 12)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	62
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NCK2_HUMAN
NC score	0.233976 (rank : 13)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	63
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RASA1_HUMAN
NC score	0.231073 (rank : 14)	θ value	0.000270298 (rank : 8)
Query Neighborhood Hits	228	Target Neighborhood Hits	258	Shared Neighborhood Hits	62
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

P55G_HUMAN
NC score	0.228789 (rank : 15)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	228	Target Neighborhood Hits	451	Shared Neighborhood Hits	59
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.225877 (rank : 16)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	228	Target Neighborhood Hits	401	Shared Neighborhood Hits	56
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PLCG1_HUMAN
NC score	0.219421 (rank : 17)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	228	Target Neighborhood Hits	293	Shared Neighborhood Hits	62
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.217428 (rank : 18)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

GRB2_MOUSE
NC score	0.216379 (rank : 19)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	62
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.216336 (rank : 20)	θ value	0.0563607 (rank : 37)
Query Neighborhood Hits	228	Target Neighborhood Hits	310	Shared Neighborhood Hits	62
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

P85A_MOUSE
NC score	0.216234 (rank : 21)	θ value	0.0330416 (rank : 30)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	60
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_HUMAN
NC score	0.214345 (rank : 22)	θ value	0.0330416 (rank : 29)
Query Neighborhood Hits	228	Target Neighborhood Hits	479	Shared Neighborhood Hits	62
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHC3_MOUSE
NC score	0.214166 (rank : 23)	θ value	0.0563607 (rank : 39)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC3_HUMAN
NC score	0.205746 (rank : 24)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	228	Target Neighborhood Hits	155	Shared Neighborhood Hits	51
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHE_HUMAN
NC score	0.182770 (rank : 25)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	228	Target Neighborhood Hits	164	Shared Neighborhood Hits	57
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
NC score	0.180703 (rank : 26)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	228	Target Neighborhood Hits	169	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHC2_MOUSE
NC score	0.173323 (rank : 27)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

VAV3_HUMAN
NC score	0.161739 (rank : 28)	θ value	0.0252991 (rank : 25)
Query Neighborhood Hits	228	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SHC2_HUMAN
NC score	0.159472 (rank : 29)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	57
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

VAV3_MOUSE
NC score	0.158991 (rank : 30)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	228	Target Neighborhood Hits	404	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SHC1_MOUSE
NC score	0.155478 (rank : 31)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	228	Target Neighborhood Hits	180	Shared Neighborhood Hits	59
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRAP2_MOUSE
NC score	0.154105 (rank : 32)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	228	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.154030 (rank : 33)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	228	Target Neighborhood Hits	304	Shared Neighborhood Hits	58
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRKL_MOUSE
NC score	0.152690 (rank : 34)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	57
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH21A_MOUSE
NC score	0.150540 (rank : 35)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

CRKL_HUMAN
NC score	0.146892 (rank : 36)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	228	Target Neighborhood Hits	313	Shared Neighborhood Hits	56
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SHC1_HUMAN
NC score	0.145322 (rank : 37)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

VAV2_HUMAN
NC score	0.144409 (rank : 38)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	60
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.144058 (rank : 39)	θ value	3.0926 (rank : 152)
Query Neighborhood Hits	228	Target Neighborhood Hits	456	Shared Neighborhood Hits	61
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SH21B_HUMAN
NC score	0.144040 (rank : 40)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SLAP2_MOUSE
NC score	0.143946 (rank : 41)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	228	Target Neighborhood Hits	136	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SH21B_MOUSE
NC score	0.141447 (rank : 42)	θ value	4.03905 (rank : 166)
Query Neighborhood Hits	228	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

CN155_HUMAN
NC score	0.141190 (rank : 43)	θ value	0.0148317 (rank : 21)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CRK_HUMAN
NC score	0.140923 (rank : 44)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	228	Target Neighborhood Hits	308	Shared Neighborhood Hits	58
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH21A_HUMAN
NC score	0.139802 (rank : 45)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	228	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

CRK_MOUSE
NC score	0.139564 (rank : 46)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	59
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

LNK_MOUSE
NC score	0.137217 (rank : 47)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	228	Target Neighborhood Hits	132	Shared Neighborhood Hits	46
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

WASL_MOUSE
NC score	0.135950 (rank : 48)	θ value	0.0193708 (rank : 22)
Query Neighborhood Hits	228	Target Neighborhood Hits	339	Shared Neighborhood Hits	34
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

SHB_MOUSE
NC score	0.135449 (rank : 49)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SLAP2_HUMAN
NC score	0.134219 (rank : 50)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	228	Target Neighborhood Hits	139	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SHB_HUMAN
NC score	0.132756 (rank : 51)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	228	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PTN11_MOUSE
NC score	0.132264 (rank : 52)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.132248 (rank : 53)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

VAV_HUMAN
NC score	0.130041 (rank : 54)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	228	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VGF_HUMAN
NC score	0.128502 (rank : 55)	θ value	0.47712 (rank : 79)
Query Neighborhood Hits	228	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

SLAP1_HUMAN
NC score	0.128095 (rank : 56)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	228	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

LNK_HUMAN
NC score	0.127629 (rank : 57)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	228	Target Neighborhood Hits	151	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SLAP1_MOUSE
NC score	0.127570 (rank : 58)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	228	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

BTK_MOUSE
NC score	0.127205 (rank : 59)	θ value	0.000270298 (rank : 7)
Query Neighborhood Hits	228	Target Neighborhood Hits	1017	Shared Neighborhood Hits	68
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTK_HUMAN
NC score	0.126866 (rank : 60)	θ value	0.00035302 (rank : 9)
Query Neighborhood Hits	228	Target Neighborhood Hits	1026	Shared Neighborhood Hits	68
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

3BP2_HUMAN
NC score	0.126467 (rank : 61)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	228	Target Neighborhood Hits	296	Shared Neighborhood Hits	54
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

LAD1_HUMAN
NC score	0.126406 (rank : 62)	θ value	0.0736092 (rank : 41)
Query Neighborhood Hits	228	Target Neighborhood Hits	441	Shared Neighborhood Hits	47
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

VAV_MOUSE
NC score	0.125401 (rank : 63)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	228	Target Neighborhood Hits	430	Shared Neighborhood Hits	53
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SHD_MOUSE
NC score	0.125318 (rank : 64)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

TEC_HUMAN
NC score	0.122177 (rank : 65)	θ value	0.00020696 (rank : 5)
Query Neighborhood Hits	228	Target Neighborhood Hits	1006	Shared Neighborhood Hits	67
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SHD_HUMAN
NC score	0.121603 (rank : 66)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	228	Target Neighborhood Hits	204	Shared Neighborhood Hits	55
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SH24A_HUMAN
NC score	0.119895 (rank : 67)	θ value	5.27518 (rank : 182)
Query Neighborhood Hits	228	Target Neighborhood Hits	455	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

TEC_MOUSE
NC score	0.118680 (rank : 68)	θ value	0.000602161 (rank : 11)
Query Neighborhood Hits	228	Target Neighborhood Hits	1006	Shared Neighborhood Hits	63
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

APS_HUMAN
NC score	0.118572 (rank : 69)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	228	Target Neighborhood Hits	162	Shared Neighborhood Hits	50
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

TXK_HUMAN
NC score	0.117621 (rank : 70)	θ value	0.00020696 (rank : 6)
Query Neighborhood Hits	228	Target Neighborhood Hits	971	Shared Neighborhood Hits	63
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BMX_MOUSE
NC score	0.116494 (rank : 71)	θ value	0.000602161 (rank : 10)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	68
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.115659 (rank : 72)	θ value	0.00298849 (rank : 14)
Query Neighborhood Hits	228	Target Neighborhood Hits	942	Shared Neighborhood Hits	69
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ECM1_HUMAN
NC score	0.115085 (rank : 73)	θ value	0.0736092 (rank : 40)
Query Neighborhood Hits	228	Target Neighborhood Hits	182	Shared Neighborhood Hits	21
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

TXK_MOUSE
NC score	0.113532 (rank : 74)	θ value	0.00390308 (rank : 16)
Query Neighborhood Hits	228	Target Neighborhood Hits	980	Shared Neighborhood Hits	63
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ABL1_MOUSE
NC score	0.107791 (rank : 75)	θ value	0.0431538 (rank : 34)
Query Neighborhood Hits	228	Target Neighborhood Hits	1178	Shared Neighborhood Hits	90
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SRRM1_MOUSE
NC score	0.107458 (rank : 76)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	228	Target Neighborhood Hits	966	Shared Neighborhood Hits	82
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ITK_HUMAN
NC score	0.106676 (rank : 77)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	228	Target Neighborhood Hits	1016	Shared Neighborhood Hits	69
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ABL1_HUMAN
NC score	0.106618 (rank : 78)	θ value	0.0431538 (rank : 33)
Query Neighborhood Hits	228	Target Neighborhood Hits	1220	Shared Neighborhood Hits	86
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ITK_MOUSE
NC score	0.105375 (rank : 79)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	228	Target Neighborhood Hits	985	Shared Neighborhood Hits	67
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

FGR_MOUSE
NC score	0.105348 (rank : 80)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	228	Target Neighborhood Hits	1069	Shared Neighborhood Hits	71
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MLL4_HUMAN
NC score	0.105086 (rank : 81)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	228	Target Neighborhood Hits	722	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

FGR_HUMAN
NC score	0.104150 (rank : 82)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	228	Target Neighborhood Hits	1067	Shared Neighborhood Hits	72
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ABL2_HUMAN
NC score	0.102763 (rank : 83)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	228	Target Neighborhood Hits	1045	Shared Neighborhood Hits	75
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

APS_MOUSE
NC score	0.102669 (rank : 84)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

PCLO_HUMAN
NC score	0.102641 (rank : 85)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	228	Target Neighborhood Hits	2046	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

3BP2_MOUSE
NC score	0.102475 (rank : 86)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	228	Target Neighborhood Hits	142	Shared Neighborhood Hits	30
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

WASF1_HUMAN
NC score	0.102211 (rank : 87)	θ value	0.0330416 (rank : 32)
Query Neighborhood Hits	228	Target Neighborhood Hits	260	Shared Neighborhood Hits	28
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

SOCS2_MOUSE
NC score	0.102185 (rank : 88)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	228	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

FRK_HUMAN
NC score	0.101780 (rank : 89)	θ value	0.0252991 (rank : 23)
Query Neighborhood Hits	228	Target Neighborhood Hits	1058	Shared Neighborhood Hits	70
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

NACAM_MOUSE
NC score	0.100686 (rank : 90)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	228	Target Neighborhood Hits	1866	Shared Neighborhood Hits	118
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

AFF1_HUMAN
NC score	0.100633 (rank : 91)	θ value	0.0330416 (rank : 26)
Query Neighborhood Hits	228	Target Neighborhood Hits	506	Shared Neighborhood Hits	58
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

WASF1_MOUSE
NC score	0.099975 (rank : 92)	θ value	0.0736092 (rank : 42)
Query Neighborhood Hits	228	Target Neighborhood Hits	261	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

SRRM1_HUMAN
NC score	0.099400 (rank : 93)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	228	Target Neighborhood Hits	690	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

WASL_HUMAN
NC score	0.098717 (rank : 94)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	228	Target Neighborhood Hits	312	Shared Neighborhood Hits	33
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

SRC_HUMAN
NC score	0.097227 (rank : 95)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	228	Target Neighborhood Hits	1058	Shared Neighborhood Hits	69
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SOCS2_HUMAN
NC score	0.097161 (rank : 96)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	228	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SRC_MOUSE
NC score	0.096780 (rank : 97)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	228	Target Neighborhood Hits	1033	Shared Neighborhood Hits	69
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HSH2D_HUMAN
NC score	0.096708 (rank : 98)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	228	Target Neighborhood Hits	159	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

PRB4S_HUMAN
NC score	0.096283 (rank : 99)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	228	Target Neighborhood Hits	330	Shared Neighborhood Hits	37
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

GRB14_MOUSE
NC score	0.095966 (rank : 100)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	228	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

YES_HUMAN
NC score	0.094894 (rank : 101)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	228	Target Neighborhood Hits	1059	Shared Neighborhood Hits	68
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.094838 (rank : 102)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	228	Target Neighborhood Hits	1052	Shared Neighborhood Hits	67
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.094672 (rank : 103)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	228	Target Neighborhood Hits	1073	Shared Neighborhood Hits	68
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FYN_HUMAN
NC score	0.094057 (rank : 104)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	228	Target Neighborhood Hits	1078	Shared Neighborhood Hits	69
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SH23A_HUMAN
NC score	0.093922 (rank : 105)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	228	Target Neighborhood Hits	149	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

WASIP_HUMAN
NC score	0.093534 (rank : 106)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	228	Target Neighborhood Hits	458	Shared Neighborhood Hits	42
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

PTN6_MOUSE
NC score	0.092467 (rank : 107)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

HSH2D_MOUSE
NC score	0.092208 (rank : 108)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	228	Target Neighborhood Hits	124	Shared Neighborhood Hits	41
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SRRM2_MOUSE
NC score	0.091654 (rank : 109)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	228	Target Neighborhood Hits	1470	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

HCK_HUMAN
NC score	0.091633 (rank : 110)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	228	Target Neighborhood Hits	1035	Shared Neighborhood Hits	68
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
NC score	0.091557 (rank : 111)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	228	Target Neighborhood Hits	1029	Shared Neighborhood Hits	66
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SRRM2_HUMAN
NC score	0.090999 (rank : 112)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	228	Target Neighborhood Hits	1296	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

BLK_MOUSE
NC score	0.090745 (rank : 113)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	228	Target Neighborhood Hits	992	Shared Neighborhood Hits	66
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CSK_HUMAN
NC score	0.090275 (rank : 114)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	65
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

GGN_MOUSE
NC score	0.090154 (rank : 115)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	228	Target Neighborhood Hits	311	Shared Neighborhood Hits	35
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

SH2D3_HUMAN
NC score	0.090113 (rank : 116)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	228	Target Neighborhood Hits	188	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

TENS4_MOUSE
NC score	0.090016 (rank : 117)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	228	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

CSK_MOUSE
NC score	0.089999 (rank : 118)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	65
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

NOLC1_HUMAN
NC score	0.089934 (rank : 119)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	228	Target Neighborhood Hits	452	Shared Neighborhood Hits	44
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

SF3A1_HUMAN
NC score	0.089896 (rank : 120)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	228	Target Neighborhood Hits	199	Shared Neighborhood Hits	22
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SH2D3_MOUSE
NC score	0.089874 (rank : 121)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	228	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

LYN_MOUSE
NC score	0.089406 (rank : 122)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	228	Target Neighborhood Hits	1023	Shared Neighborhood Hits	68
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PTN6_HUMAN
NC score	0.089212 (rank : 123)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	228	Target Neighborhood Hits	234	Shared Neighborhood Hits	55
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

LYN_HUMAN
NC score	0.089159 (rank : 124)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	228	Target Neighborhood Hits	1022	Shared Neighborhood Hits	68
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PTK6_MOUSE
NC score	0.089040 (rank : 125)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	228	Target Neighborhood Hits	1026	Shared Neighborhood Hits	65
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

GRB14_HUMAN
NC score	0.088927 (rank : 126)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	228	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MBB1A_HUMAN
NC score	0.088551 (rank : 127)	θ value	0.0330416 (rank : 28)
Query Neighborhood Hits	228	Target Neighborhood Hits	665	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

LCK_HUMAN
NC score	0.088306 (rank : 128)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	228	Target Neighborhood Hits	987	Shared Neighborhood Hits	64
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SNP29_MOUSE
NC score	0.088213 (rank : 129)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	228	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ERB0, Q3UGN0, Q9DBC5	Gene names	Snap29
Domain Architecture
Description	Synaptosomal-associated protein 29 (SNAP-29) (Vesicle-membrane fusion protein SNAP-29) (Soluble 29 kDa NSF attachment protein) (Golgi SNARE of 32 kDa) (Gs32).

FER_HUMAN
NC score	0.087620 (rank : 130)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	228	Target Neighborhood Hits	1278	Shared Neighborhood Hits	70
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SHAN2_MOUSE
NC score	0.087610 (rank : 131)	θ value	0.62314 (rank : 87)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	45
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

LCK_MOUSE
NC score	0.087475 (rank : 132)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	228	Target Neighborhood Hits	981	Shared Neighborhood Hits	63
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MLL2_HUMAN
NC score	0.086817 (rank : 133)	θ value	0.0252991 (rank : 24)
Query Neighborhood Hits	228	Target Neighborhood Hits	1788	Shared Neighborhood Hits	92
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

BLK_HUMAN
NC score	0.086535 (rank : 134)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	228	Target Neighborhood Hits	994	Shared Neighborhood Hits	66
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CCNK_MOUSE
NC score	0.085622 (rank : 135)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	35
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

TXND2_HUMAN
NC score	0.085354 (rank : 136)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	228	Target Neighborhood Hits	793	Shared Neighborhood Hits	78
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

SOCS7_MOUSE
NC score	0.084833 (rank : 137)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	228	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

BCAR3_HUMAN
NC score	0.084787 (rank : 138)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	228	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

SRMS_MOUSE
NC score	0.084509 (rank : 139)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	228	Target Neighborhood Hits	964	Shared Neighborhood Hits	61
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MATK_HUMAN
NC score	0.083896 (rank : 140)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	228	Target Neighborhood Hits	954	Shared Neighborhood Hits	62
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SRMS_HUMAN
NC score	0.083856 (rank : 141)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	228	Target Neighborhood Hits	946	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

MLL3_HUMAN
NC score	0.083519 (rank : 142)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	228	Target Neighborhood Hits	1644	Shared Neighborhood Hits	87
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PTK6_HUMAN
NC score	0.083461 (rank : 143)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	63
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

GRB7_MOUSE
NC score	0.083357 (rank : 144)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SOCS6_MOUSE
NC score	0.083337 (rank : 145)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	228	Target Neighborhood Hits	146	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

MATK_MOUSE
NC score	0.083016 (rank : 146)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	228	Target Neighborhood Hits	952	Shared Neighborhood Hits	62
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

BCAR3_MOUSE
NC score	0.082458 (rank : 147)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	228	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SOCS6_HUMAN
NC score	0.082307 (rank : 148)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	228	Target Neighborhood Hits	126	Shared Neighborhood Hits	35
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

IWS1_HUMAN
NC score	0.082235 (rank : 149)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	228	Target Neighborhood Hits	1241	Shared Neighborhood Hits	92
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SH24A_MOUSE
NC score	0.081907 (rank : 150)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	228	Target Neighborhood Hits	326	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

CJ012_HUMAN
NC score	0.081096 (rank : 151)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

NPHP1_MOUSE
NC score	0.080678 (rank : 152)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	228	Target Neighborhood Hits	267	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SET1A_HUMAN
NC score	0.080621 (rank : 153)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	228	Target Neighborhood Hits	690	Shared Neighborhood Hits	57
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

PRRT3_HUMAN
NC score	0.080619 (rank : 154)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	228	Target Neighborhood Hits	998	Shared Neighborhood Hits	83
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SH22A_MOUSE
NC score	0.079063 (rank : 155)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	228	Target Neighborhood Hits	179	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

HCLS1_HUMAN
NC score	0.078916 (rank : 156)	θ value	6.88961 (rank : 196)
Query Neighborhood Hits	228	Target Neighborhood Hits	358	Shared Neighborhood Hits	60
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRB7_HUMAN
NC score	0.078562 (rank : 157)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

AFF1_MOUSE
NC score	0.078110 (rank : 158)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	228	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CISH_HUMAN
NC score	0.077262 (rank : 159)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	228	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

ZAP70_MOUSE
NC score	0.077244 (rank : 160)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	228	Target Neighborhood Hits	905	Shared Neighborhood Hits	64
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CISH_MOUSE
NC score	0.077020 (rank : 161)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	228	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

KSYK_MOUSE
NC score	0.076960 (rank : 162)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	228	Target Neighborhood Hits	944	Shared Neighborhood Hits	63
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

IWS1_MOUSE
NC score	0.076855 (rank : 163)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	228	Target Neighborhood Hits	1258	Shared Neighborhood Hits	83
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KSYK_HUMAN
NC score	0.076586 (rank : 164)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	228	Target Neighborhood Hits	901	Shared Neighborhood Hits	60
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MDC1_MOUSE
NC score	0.076294 (rank : 165)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	228	Target Neighborhood Hits	998	Shared Neighborhood Hits	87
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

CCDC9_MOUSE
NC score	0.076275 (rank : 166)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	228	Target Neighborhood Hits	196	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VC31	Gene names	Ccdc9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

MDC1_HUMAN
NC score	0.076033 (rank : 167)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	228	Target Neighborhood Hits	1446	Shared Neighborhood Hits	99
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SF3A1_MOUSE
NC score	0.075908 (rank : 168)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

ZAP70_HUMAN
NC score	0.075811 (rank : 169)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	228	Target Neighborhood Hits	893	Shared Neighborhood Hits	63
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

PRG4_HUMAN
NC score	0.075561 (rank : 170)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	228	Target Neighborhood Hits	764	Shared Neighborhood Hits	70
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ENL_HUMAN
NC score	0.075155 (rank : 171)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	228	Target Neighborhood Hits	305	Shared Neighborhood Hits	36
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

HCLS1_MOUSE
NC score	0.074827 (rank : 172)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	228	Target Neighborhood Hits	329	Shared Neighborhood Hits	53
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRBS1_MOUSE
NC score	0.074438 (rank : 173)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	228	Target Neighborhood Hits	409	Shared Neighborhood Hits	56
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NPHP1_HUMAN
NC score	0.074214 (rank : 174)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	31
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RGS3_HUMAN
NC score	0.074212 (rank : 175)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	228	Target Neighborhood Hits	1375	Shared Neighborhood Hits	96
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TARSH_HUMAN
NC score	0.073667 (rank : 176)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	228	Target Neighborhood Hits	768	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

SON_HUMAN
NC score	0.073442 (rank : 177)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	228	Target Neighborhood Hits	1568	Shared Neighborhood Hits	91
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

LAD1_MOUSE
NC score	0.073219 (rank : 178)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	228	Target Neighborhood Hits	391	Shared Neighborhood Hits	45
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

BSN_MOUSE
NC score	0.072761 (rank : 179)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	228	Target Neighborhood Hits	2057	Shared Neighborhood Hits	101
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

BRD4_HUMAN
NC score	0.072511 (rank : 180)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	228	Target Neighborhood Hits	851	Shared Neighborhood Hits	56
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

STAM2_MOUSE
NC score	0.072029 (rank : 181)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	228	Target Neighborhood Hits	285	Shared Neighborhood Hits	35
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

BRD4_MOUSE
NC score	0.071892 (rank : 182)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	228	Target Neighborhood Hits	845	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

TENS4_HUMAN
NC score	0.071823 (rank : 183)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	228	Target Neighborhood Hits	214	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

SH22A_HUMAN
NC score	0.071780 (rank : 184)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

CD2AP_MOUSE
NC score	0.071119 (rank : 185)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	228	Target Neighborhood Hits	336	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

STAM2_HUMAN
NC score	0.070471 (rank : 186)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	228	Target Neighborhood Hits	288	Shared Neighborhood Hits	39
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

IASPP_MOUSE
NC score	0.070294 (rank : 187)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	228	Target Neighborhood Hits	1024	Shared Neighborhood Hits	67
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

STAM1_MOUSE
NC score	0.070242 (rank : 188)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	228	Target Neighborhood Hits	273	Shared Neighborhood Hits	35
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SRBS1_HUMAN
NC score	0.069897 (rank : 189)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

RGS3_MOUSE
NC score	0.069600 (rank : 190)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	228	Target Neighborhood Hits	1621	Shared Neighborhood Hits	105
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

STAM1_HUMAN
NC score	0.069217 (rank : 191)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	228	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

YLPM1_MOUSE
NC score	0.069197 (rank : 192)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	228	Target Neighborhood Hits	505	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

BASP_HUMAN
NC score	0.068600 (rank : 193)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	228	Target Neighborhood Hits	321	Shared Neighborhood Hits	31
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

MLL3_MOUSE
NC score	0.068079 (rank : 194)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	228	Target Neighborhood Hits	1399	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PELP1_MOUSE
NC score	0.067952 (rank : 195)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	228	Target Neighborhood Hits	709	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

WASF4_HUMAN
NC score	0.067616 (rank : 196)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	228	Target Neighborhood Hits	282	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

FES_HUMAN
NC score	0.067607 (rank : 197)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	228	Target Neighborhood Hits	978	Shared Neighborhood Hits	53
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

VINEX_MOUSE
NC score	0.067514 (rank : 198)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	228	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SH3K1_HUMAN
NC score	0.067152 (rank : 199)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	228	Target Neighborhood Hits	341	Shared Neighborhood Hits	38
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PRG4_MOUSE
NC score	0.067140 (rank : 200)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	228	Target Neighborhood Hits	624	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

FA47A_HUMAN
NC score	0.066902 (rank : 201)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	228	Target Neighborhood Hits	451	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GRB10_MOUSE
NC score	0.066877 (rank : 202)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	228	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

ARMX6_HUMAN
NC score	0.066684 (rank : 203)	θ value	0.0961366 (rank : 44)
Query Neighborhood Hits	228	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q7L4S7, Q9NWJ3	Gene names	ARMCX6
Domain Architecture	No domain graphic available
Description	Protein ARMCX6.

YLPM1_HUMAN
NC score	0.066561 (rank : 204)	θ value	5.27518 (rank : 189)
Query Neighborhood Hits	228	Target Neighborhood Hits	670	Shared Neighborhood Hits	51
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

GRB10_HUMAN
NC score	0.066462 (rank : 205)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	228	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

HRX_HUMAN
NC score	0.065749 (rank : 206)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	228	Target Neighborhood Hits	825	Shared Neighborhood Hits	59
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

PCLO_MOUSE
NC score	0.065722 (rank : 207)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	228	Target Neighborhood Hits	2275	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

STAC_MOUSE
NC score	0.065488 (rank : 208)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	228	Target Neighborhood Hits	268	Shared Neighborhood Hits	30
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

WASIP_MOUSE
NC score	0.064987 (rank : 209)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	228	Target Neighborhood Hits	392	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

NCOA6_HUMAN
NC score	0.064482 (rank : 210)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	228	Target Neighborhood Hits	1202	Shared Neighborhood Hits	90
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MAP1A_HUMAN
NC score	0.064367 (rank : 211)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	228	Target Neighborhood Hits	1626	Shared Neighborhood Hits	90
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

SH3K1_MOUSE
NC score	0.064327 (rank : 212)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	228	Target Neighborhood Hits	332	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

PPIP1_HUMAN
NC score	0.064248 (rank : 213)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

FES_MOUSE
NC score	0.064148 (rank : 214)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	228	Target Neighborhood Hits	980	Shared Neighborhood Hits	47
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ABI2_HUMAN
NC score	0.064088 (rank : 215)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	228	Target Neighborhood Hits	350	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NU214_HUMAN
NC score	0.064029 (rank : 216)	θ value	5.27518 (rank : 179)
Query Neighborhood Hits	228	Target Neighborhood Hits	657	Shared Neighborhood Hits	42
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

ACK1_HUMAN
NC score	0.063923 (rank : 217)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	228	Target Neighborhood Hits	1140	Shared Neighborhood Hits	75
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

WASF2_MOUSE
NC score	0.063719 (rank : 218)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	228	Target Neighborhood Hits	315	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ACK1_MOUSE
NC score	0.062956 (rank : 219)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	228	Target Neighborhood Hits	1080	Shared Neighborhood Hits	62
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

K1543_MOUSE
NC score	0.062944 (rank : 220)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	228	Target Neighborhood Hits	497	Shared Neighborhood Hits	51
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

VINEX_HUMAN
NC score	0.062419 (rank : 221)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	228	Target Neighborhood Hits	270	Shared Neighborhood Hits	36
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

DNMBP_MOUSE
NC score	0.062234 (rank : 222)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	228	Target Neighborhood Hits	435	Shared Neighborhood Hits	56
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

AATK_HUMAN
NC score	0.062143 (rank : 223)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	228	Target Neighborhood Hits	1243	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

NFH_MOUSE
NC score	0.062053 (rank : 224)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	228	Target Neighborhood Hits	2247	Shared Neighborhood Hits	115
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

AATK_MOUSE
NC score	0.061971 (rank : 225)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	228	Target Neighborhood Hits	942	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

SHAN2_HUMAN
NC score	0.061384 (rank : 226)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	228	Target Neighborhood Hits	346	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

STAC_HUMAN
NC score	0.061291 (rank : 227)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	228	Target Neighborhood Hits	276	Shared Neighborhood Hits	33
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BCL9_HUMAN
NC score	0.060968 (rank : 228)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	228	Target Neighborhood Hits	1008	Shared Neighborhood Hits	63
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

FA47B_HUMAN
NC score	0.060889 (rank : 229)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	228	Target Neighborhood Hits	431	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

PRP1_HUMAN
NC score	0.060865 (rank : 230)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

ECM1_MOUSE
NC score	0.060850 (rank : 231)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	228	Target Neighborhood Hits	105	Shared Neighborhood Hits	20
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

ITSN1_HUMAN
NC score	0.060798 (rank : 232)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	228	Target Neighborhood Hits	1757	Shared Neighborhood Hits	95
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ASPP1_MOUSE
NC score	0.060722 (rank : 233)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	228	Target Neighborhood Hits	1244	Shared Neighborhood Hits	86
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CD2AP_HUMAN
NC score	0.060670 (rank : 234)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	228	Target Neighborhood Hits	315	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DNMBP_HUMAN
NC score	0.060529 (rank : 235)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	228	Target Neighborhood Hits	413	Shared Neighborhood Hits	42
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GAB1_HUMAN
NC score	0.060493 (rank : 236)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	228	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
NC score	0.059991 (rank : 237)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	228	Target Neighborhood Hits	233	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

WASF2_HUMAN
NC score	0.059877 (rank : 238)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

PPIP1_MOUSE
NC score	0.059839 (rank : 239)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	228	Target Neighborhood Hits	377	Shared Neighborhood Hits	42
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

LTK_MOUSE
NC score	0.059709 (rank : 240)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	228	Target Neighborhood Hits	770	Shared Neighborhood Hits	28
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LTK_HUMAN
NC score	0.059557 (rank : 241)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	228	Target Neighborhood Hits	774	Shared Neighborhood Hits	27
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

EFS_MOUSE
NC score	0.059263 (rank : 242)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	228	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ITSN1_MOUSE
NC score	0.058964 (rank : 243)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	228	Target Neighborhood Hits	1669	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ANK2_HUMAN
NC score	0.058893 (rank : 244)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	228	Target Neighborhood Hits	1615	Shared Neighborhood Hits	98
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ALK_MOUSE
NC score	0.058830 (rank : 245)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	228	Target Neighborhood Hits	811	Shared Neighborhood Hits	31
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

RASA2_MOUSE
NC score	0.058736 (rank : 246)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	228	Target Neighborhood Hits	159	Shared Neighborhood Hits	20
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

BCAR1_HUMAN
NC score	0.058592 (rank : 247)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	228	Target Neighborhood Hits	554	Shared Neighborhood Hits	71
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ALK_HUMAN
NC score	0.058560 (rank : 248)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	228	Target Neighborhood Hits	795	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ACINU_MOUSE
NC score	0.058503 (rank : 249)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	228	Target Neighborhood Hits	712	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

IASPP_HUMAN
NC score	0.058413 (rank : 250)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	228	Target Neighborhood Hits	688	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RAPH1_HUMAN
NC score	0.058307 (rank : 251)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	228	Target Neighborhood Hits	593	Shared Neighborhood Hits	59
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

CHIN_MOUSE
NC score	0.058204 (rank : 252)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	41
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SYNPO_MOUSE
NC score	0.058173 (rank : 253)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

SPN90_HUMAN
NC score	0.058172 (rank : 254)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STYK1_HUMAN
NC score	0.058127 (rank : 255)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	228	Target Neighborhood Hits	786	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

OSTF1_HUMAN
NC score	0.057997 (rank : 256)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	228	Target Neighborhood Hits	466	Shared Neighborhood Hits	31
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

MAP4_HUMAN
NC score	0.057889 (rank : 257)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	228	Target Neighborhood Hits	428	Shared Neighborhood Hits	51
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

ES8L3_HUMAN
NC score	0.057775 (rank : 258)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	228	Target Neighborhood Hits	206	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

TGON2_HUMAN
NC score	0.057600 (rank : 259)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	72
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

MAGE1_HUMAN
NC score	0.057524 (rank : 260)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	228	Target Neighborhood Hits	1389	Shared Neighborhood Hits	92
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

RASA2_HUMAN
NC score	0.057477 (rank : 261)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	18
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

TP53B_MOUSE
NC score	0.057343 (rank : 262)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	228	Target Neighborhood Hits	644	Shared Neighborhood Hits	68
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

STAC3_HUMAN
NC score	0.057318 (rank : 263)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	30
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ERBB2_HUMAN
NC score	0.057108 (rank : 264)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	228	Target Neighborhood Hits	1073	Shared Neighborhood Hits	48
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ROS_HUMAN
NC score	0.056934 (rank : 265)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	228	Target Neighborhood Hits	907	Shared Neighborhood Hits	31
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

DBNL_HUMAN
NC score	0.056816 (rank : 266)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	228	Target Neighborhood Hits	244	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

NTRK3_HUMAN
NC score	0.056732 (rank : 267)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	228	Target Neighborhood Hits	1115	Shared Neighborhood Hits	29
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

STYK1_MOUSE
NC score	0.056586 (rank : 268)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	228	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CHIN_HUMAN
NC score	0.056485 (rank : 269)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	228	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

TARA_HUMAN
NC score	0.056253 (rank : 270)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	228	Target Neighborhood Hits	1626	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SON_MOUSE
NC score	0.056200 (rank : 271)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	228	Target Neighborhood Hits	957	Shared Neighborhood Hits	73
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

TAF6_HUMAN
NC score	0.056162 (rank : 272)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	228	Target Neighborhood Hits	127	Shared Neighborhood Hits	17
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

NTRK1_HUMAN
NC score	0.056157 (rank : 273)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	228	Target Neighborhood Hits	1023	Shared Neighborhood Hits	29
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

MERTK_HUMAN
NC score	0.056066 (rank : 274)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	30
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

M3K11_HUMAN
NC score	0.056043 (rank : 275)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	228	Target Neighborhood Hits	1136	Shared Neighborhood Hits	60
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TACC2_HUMAN
NC score	0.056012 (rank : 276)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	228	Target Neighborhood Hits	856	Shared Neighborhood Hits	52
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

RYK_HUMAN
NC score	0.055888 (rank : 277)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	228	Target Neighborhood Hits	701	Shared Neighborhood Hits	26
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

FYB_HUMAN
NC score	0.055790 (rank : 278)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	228	Target Neighborhood Hits	379	Shared Neighborhood Hits	44
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

DBNL_MOUSE
NC score	0.055630 (rank : 279)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	228	Target Neighborhood Hits	306	Shared Neighborhood Hits	35
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

GGN_HUMAN
NC score	0.055588 (rank : 280)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	24
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

OSTF1_MOUSE
NC score	0.055581 (rank : 281)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	228	Target Neighborhood Hits	467	Shared Neighborhood Hits	31
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DDR1_MOUSE
NC score	0.055552 (rank : 282)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	228	Target Neighborhood Hits	818	Shared Neighborhood Hits	30
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.055528 (rank : 283)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	228	Target Neighborhood Hits	819	Shared Neighborhood Hits	29
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

SRC8_HUMAN
NC score	0.055487 (rank : 284)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	228	Target Neighborhood Hits	269	Shared Neighborhood Hits	39
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

RYK_MOUSE
NC score	0.055469 (rank : 285)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	228	Target Neighborhood Hits	715	Shared Neighborhood Hits	26
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

STAC3_MOUSE
NC score	0.055360 (rank : 286)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	228	Target Neighborhood Hits	232	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

MERTK_MOUSE
NC score	0.055327 (rank : 287)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	228	Target Neighborhood Hits	974	Shared Neighborhood Hits	29
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

FLT3_MOUSE
NC score	0.055321 (rank : 288)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	228	Target Neighborhood Hits	847	Shared Neighborhood Hits	28
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

RASA3_MOUSE
NC score	0.055257 (rank : 289)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	228	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

BAG3_MOUSE
NC score	0.055244 (rank : 290)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	228	Target Neighborhood Hits	513	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

RASA3_HUMAN
NC score	0.055235 (rank : 291)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

IGF1R_HUMAN
NC score	0.054784 (rank : 292)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	228	Target Neighborhood Hits	977	Shared Neighborhood Hits	32
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
NC score	0.054750 (rank : 293)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	228	Target Neighborhood Hits	950	Shared Neighborhood Hits	32
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

FAK2_HUMAN
NC score	0.054737 (rank : 294)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	228	Target Neighborhood Hits	847	Shared Neighborhood Hits	27
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

BAG3_HUMAN
NC score	0.054699 (rank : 295)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	228	Target Neighborhood Hits	314	Shared Neighborhood Hits	33
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

TNK1_HUMAN
NC score	0.054606 (rank : 296)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	228	Target Neighborhood Hits	815	Shared Neighborhood Hits	32
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

SPN90_MOUSE
NC score	0.054517 (rank : 297)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	228	Target Neighborhood Hits	157	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

IGF1R_MOUSE
NC score	0.054490 (rank : 298)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	228	Target Neighborhood Hits	973	Shared Neighborhood Hits	31
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

FAK2_MOUSE
NC score	0.054462 (rank : 299)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	228	Target Neighborhood Hits	851	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

NTRK2_MOUSE
NC score	0.054414 (rank : 300)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	228	Target Neighborhood Hits	1088	Shared Neighborhood Hits	29
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.054413 (rank : 301)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	228	Target Neighborhood Hits	1081	Shared Neighborhood Hits	29
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

ERBB4_HUMAN
NC score	0.054393 (rank : 302)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	228	Target Neighborhood Hits	910	Shared Neighborhood Hits	28
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

UFO_HUMAN
NC score	0.054359 (rank : 303)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	228	Target Neighborhood Hits	981	Shared Neighborhood Hits	31
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

DDR2_HUMAN
NC score	0.054270 (rank : 304)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	228	Target Neighborhood Hits	818	Shared Neighborhood Hits	27
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ERBB2_MOUSE
NC score	0.054243 (rank : 305)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	228	Target Neighborhood Hits	918	Shared Neighborhood Hits	32
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

INSRR_MOUSE
NC score	0.054227 (rank : 306)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	228	Target Neighborhood Hits	961	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

AHI1_MOUSE
NC score	0.054222 (rank : 307)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	228	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AHI1_HUMAN
NC score	0.054194 (rank : 308)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	228	Target Neighborhood Hits	537	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG7_MOUSE
NC score	0.054183 (rank : 309)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	228	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

MUSK_MOUSE
NC score	0.054100 (rank : 310)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	228	Target Neighborhood Hits	1057	Shared Neighborhood Hits	28
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

TAF6_MOUSE
NC score	0.054058 (rank : 311)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	228	Target Neighborhood Hits	110	Shared Neighborhood Hits	14
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

DDR2_MOUSE
NC score	0.054050 (rank : 312)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	228	Target Neighborhood Hits	813	Shared Neighborhood Hits	27
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ROR2_MOUSE
NC score	0.054002 (rank : 313)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	228	Target Neighborhood Hits	1000	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

PTK7_HUMAN
NC score	0.053978 (rank : 314)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	228	Target Neighborhood Hits	1103	Shared Neighborhood Hits	28
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PGFRB_MOUSE
NC score	0.053951 (rank : 315)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	228	Target Neighborhood Hits	960	Shared Neighborhood Hits	28
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ABI2_MOUSE
NC score	0.053887 (rank : 316)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	228	Target Neighborhood Hits	266	Shared Neighborhood Hits	37
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

MUC1_HUMAN
NC score	0.053883 (rank : 317)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	65
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

UFO_MOUSE
NC score	0.053856 (rank : 318)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	32
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

FLT3_HUMAN
NC score	0.053855 (rank : 319)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	228	Target Neighborhood Hits	843	Shared Neighborhood Hits	28
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

MUSK_HUMAN
NC score	0.053852 (rank : 320)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	228	Target Neighborhood Hits	1074	Shared Neighborhood Hits	28
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

ARHG6_HUMAN
NC score	0.053842 (rank : 321)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	228	Target Neighborhood Hits	376	Shared Neighborhood Hits	34
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

DCP1B_HUMAN
NC score	0.053807 (rank : 322)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	228	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZD4, Q86XH9, Q96BP8, Q96MZ8	Gene names	DCP1B
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1B (EC 3.-.-.-).

PGFRB_HUMAN
NC score	0.053758 (rank : 323)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	228	Target Neighborhood Hits	962	Shared Neighborhood Hits	28
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ITSN2_HUMAN
NC score	0.053661 (rank : 324)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	228	Target Neighborhood Hits	1173	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

TNK1_MOUSE
NC score	0.053587 (rank : 325)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	228	Target Neighborhood Hits	806	Shared Neighborhood Hits	32
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

EPHB6_HUMAN
NC score	0.053529 (rank : 326)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	228	Target Neighborhood Hits	912	Shared Neighborhood Hits	29
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ERBB3_HUMAN
NC score	0.053525 (rank : 327)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	228	Target Neighborhood Hits	918	Shared Neighborhood Hits	27
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

EPHA6_HUMAN
NC score	0.053512 (rank : 328)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	228	Target Neighborhood Hits	959	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ERBB3_MOUSE
NC score	0.053492 (rank : 329)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	228	Target Neighborhood Hits	898	Shared Neighborhood Hits	30
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

EPHA6_MOUSE
NC score	0.053476 (rank : 330)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	228	Target Neighborhood Hits	946	Shared Neighborhood Hits	30
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

INSR_HUMAN
NC score	0.053401 (rank : 331)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	228	Target Neighborhood Hits	963	Shared Neighborhood Hits	30
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

BSN_HUMAN
NC score	0.053370 (rank : 332)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	228	Target Neighborhood Hits	1537	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

EPHA5_MOUSE
NC score	0.053255 (rank : 333)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	228	Target Neighborhood Hits	950	Shared Neighborhood Hits	31
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

WASP_HUMAN
NC score	0.053233 (rank : 334)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	228	Target Neighborhood Hits	195	Shared Neighborhood Hits	21
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

PARM1_MOUSE
NC score	0.053217 (rank : 335)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	228	Target Neighborhood Hits	140	Shared Neighborhood Hits	17
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

TEX14_HUMAN
NC score	0.053205 (rank : 336)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	228	Target Neighborhood Hits	1103	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

PGFRA_HUMAN
NC score	0.053191 (rank : 337)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	228	Target Neighborhood Hits	980	Shared Neighborhood Hits	28
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TYRO3_MOUSE
NC score	0.053165 (rank : 338)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	228	Target Neighborhood Hits	1007	Shared Neighborhood Hits	29
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

CSF1R_HUMAN
NC score	0.053113 (rank : 339)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	228	Target Neighborhood Hits	943	Shared Neighborhood Hits	28
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TYRO3_HUMAN
NC score	0.053097 (rank : 340)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	228	Target Neighborhood Hits	995	Shared Neighborhood Hits	28
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHB6_MOUSE
NC score	0.053009 (rank : 341)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	228	Target Neighborhood Hits	906	Shared Neighborhood Hits	28
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ROR1_MOUSE
NC score	0.052978 (rank : 342)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	228	Target Neighborhood Hits	1025	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

PGFRA_MOUSE
NC score	0.052912 (rank : 343)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	28
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

INSR_MOUSE
NC score	0.052848 (rank : 344)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	228	Target Neighborhood Hits	968	Shared Neighborhood Hits	30
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EGFR_HUMAN
NC score	0.052845 (rank : 345)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	228	Target Neighborhood Hits	939	Shared Neighborhood Hits	32
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EPHAA_HUMAN
NC score	0.052838 (rank : 346)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	228	Target Neighborhood Hits	960	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EGFR_MOUSE
NC score	0.052824 (rank : 347)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	228	Target Neighborhood Hits	927	Shared Neighborhood Hits	31
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHB3_MOUSE
NC score	0.052807 (rank : 348)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	32
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

IF4B_HUMAN
NC score	0.052798 (rank : 349)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	228	Target Neighborhood Hits	417	Shared Neighborhood Hits	34
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

EPHA2_MOUSE
NC score	0.052765 (rank : 350)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	32
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

ROR1_HUMAN
NC score	0.052742 (rank : 351)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	228	Target Neighborhood Hits	1018	Shared Neighborhood Hits	28
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

CSF1R_MOUSE
NC score	0.052732 (rank : 352)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	228	Target Neighborhood Hits	983	Shared Neighborhood Hits	28
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHB3_HUMAN
NC score	0.052731 (rank : 353)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	228	Target Neighborhood Hits	996	Shared Neighborhood Hits	31
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

BAT2_MOUSE
NC score	0.052731 (rank : 354)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	228	Target Neighborhood Hits	947	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

M3KL4_HUMAN
NC score	0.052707 (rank : 355)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	228	Target Neighborhood Hits	1087	Shared Neighborhood Hits	48
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

ROR2_HUMAN
NC score	0.052698 (rank : 356)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	228	Target Neighborhood Hits	1014	Shared Neighborhood Hits	30
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EPHA2_HUMAN
NC score	0.052693 (rank : 357)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	228	Target Neighborhood Hits	1021	Shared Neighborhood Hits	31
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

M3K9_HUMAN
NC score	0.052592 (rank : 358)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	228	Target Neighborhood Hits	1123	Shared Neighborhood Hits	60
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

FAK1_MOUSE
NC score	0.052489 (rank : 359)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	228	Target Neighborhood Hits	850	Shared Neighborhood Hits	31
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.052277 (rank : 360)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	228	Target Neighborhood Hits	850	Shared Neighborhood Hits	30
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FGFR4_MOUSE
NC score	0.052265 (rank : 361)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	228	Target Neighborhood Hits	1026	Shared Neighborhood Hits	29
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

ITSN2_MOUSE
NC score	0.052255 (rank : 362)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	228	Target Neighborhood Hits	1371	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MET_MOUSE
NC score	0.052248 (rank : 363)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	228	Target Neighborhood Hits	844	Shared Neighborhood Hits	26
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

SRC8_MOUSE
NC score	0.052197 (rank : 364)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	37
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

NCF2_HUMAN
NC score	0.052187 (rank : 365)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	228	Target Neighborhood Hits	229	Shared Neighborhood Hits	28
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

KIT_MOUSE
NC score	0.052184 (rank : 366)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	228	Target Neighborhood Hits	949	Shared Neighborhood Hits	28
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

RON_MOUSE
NC score	0.052151 (rank : 367)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	228	Target Neighborhood Hits	836	Shared Neighborhood Hits	25
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ASPP2_HUMAN
NC score	0.052022 (rank : 368)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	228	Target Neighborhood Hits	1156	Shared Neighborhood Hits	66
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

TITIN_HUMAN
NC score	0.051973 (rank : 369)	θ value	0.0330416 (rank : 31)
Query Neighborhood Hits	228	Target Neighborhood Hits	2923	Shared Neighborhood Hits	107
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MET_HUMAN
NC score	0.051901 (rank : 370)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	228	Target Neighborhood Hits	831	Shared Neighborhood Hits	26
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

OGFR_HUMAN
NC score	0.051892 (rank : 371)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	228	Target Neighborhood Hits	1582	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

EPHA8_MOUSE
NC score	0.051872 (rank : 372)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	228	Target Neighborhood Hits	969	Shared Neighborhood Hits	30
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

K1802_MOUSE
NC score	0.051746 (rank : 373)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	228	Target Neighborhood Hits	1596	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

RON_HUMAN
NC score	0.051665 (rank : 374)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	228	Target Neighborhood Hits	842	Shared Neighborhood Hits	26
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ARHG7_HUMAN
NC score	0.051636 (rank : 375)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	228	Target Neighborhood Hits	347	Shared Neighborhood Hits	32
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

EPHB4_MOUSE
NC score	0.051629 (rank : 376)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	228	Target Neighborhood Hits	1013	Shared Neighborhood Hits	32
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA5_HUMAN
NC score	0.051617 (rank : 377)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	33
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

KIT_HUMAN
NC score	0.051609 (rank : 378)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	228	Target Neighborhood Hits	953	Shared Neighborhood Hits	28
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

EPHB4_HUMAN
NC score	0.051575 (rank : 379)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	228	Target Neighborhood Hits	1056	Shared Neighborhood Hits	33
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

PELP1_HUMAN
NC score	0.051573 (rank : 380)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	228	Target Neighborhood Hits	596	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

CIP4_HUMAN
NC score	0.051556 (rank : 381)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	228	Target Neighborhood Hits	374	Shared Neighborhood Hits	36
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

FGFR4_HUMAN
NC score	0.051538 (rank : 382)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	30
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

EPHA8_HUMAN
NC score	0.051477 (rank : 383)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	228	Target Neighborhood Hits	956	Shared Neighborhood Hits	29
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB2_MOUSE
NC score	0.051449 (rank : 384)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	32
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.051412 (rank : 385)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	228	Target Neighborhood Hits	983	Shared Neighborhood Hits	32
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA1_MOUSE
NC score	0.051303 (rank : 386)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	228	Target Neighborhood Hits	958	Shared Neighborhood Hits	30
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

DREB_MOUSE
NC score	0.051225 (rank : 387)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	228	Target Neighborhood Hits	446	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ZN750_MOUSE
NC score	0.051216 (rank : 388)	θ value	4.03905 (rank : 168)
Query Neighborhood Hits	228	Target Neighborhood Hits	346	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

EPHA1_HUMAN
NC score	0.051187 (rank : 389)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	228	Target Neighborhood Hits	997	Shared Neighborhood Hits	27
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHB1_HUMAN
NC score	0.051122 (rank : 390)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	228	Target Neighborhood Hits	988	Shared Neighborhood Hits	31
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

TIE2_HUMAN
NC score	0.051047 (rank : 391)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	228	Target Neighborhood Hits	1192	Shared Neighborhood Hits	34
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

NCF1_HUMAN
NC score	0.050981 (rank : 392)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	228	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

RET_HUMAN
NC score	0.050972 (rank : 393)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	228	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

FGFR3_MOUSE
NC score	0.050962 (rank : 394)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	228	Target Neighborhood Hits	1059	Shared Neighborhood Hits	28
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR3_HUMAN
NC score	0.050914 (rank : 395)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	228	Target Neighborhood Hits	1042	Shared Neighborhood Hits	28
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

AB1IP_HUMAN
NC score	0.050881 (rank : 396)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	228	Target Neighborhood Hits	213	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

EPHA3_MOUSE
NC score	0.050830 (rank : 397)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	228	Target Neighborhood Hits	1009	Shared Neighborhood Hits	30
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

TIE1_MOUSE
NC score	0.050772 (rank : 398)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	228	Target Neighborhood Hits	1266	Shared Neighborhood Hits	33
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHA3_HUMAN
NC score	0.050754 (rank : 399)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	228	Target Neighborhood Hits	1005	Shared Neighborhood Hits	30
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

VGFR3_MOUSE
NC score	0.050748 (rank : 400)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	228	Target Neighborhood Hits	1056	Shared Neighborhood Hits	28
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

M3K10_HUMAN
NC score	0.050710 (rank : 401)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	228	Target Neighborhood Hits	1071	Shared Neighborhood Hits	50
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

SOCS3_MOUSE
NC score	0.050672 (rank : 402)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	228	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

EPHA4_HUMAN
NC score	0.050532 (rank : 403)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	228	Target Neighborhood Hits	975	Shared Neighborhood Hits	28
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

TIE1_HUMAN
NC score	0.050531 (rank : 404)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	228	Target Neighborhood Hits	1241	Shared Neighborhood Hits	32
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHA4_MOUSE
NC score	0.050528 (rank : 405)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	228	Target Neighborhood Hits	982	Shared Neighborhood Hits	28
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

FGFR2_MOUSE
NC score	0.050514 (rank : 406)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	228	Target Neighborhood Hits	1062	Shared Neighborhood Hits	28
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

TIE2_MOUSE
NC score	0.050459 (rank : 407)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	228	Target Neighborhood Hits	1204	Shared Neighborhood Hits	31
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

RET_MOUSE
NC score	0.050418 (rank : 408)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	228	Target Neighborhood Hits	884	Shared Neighborhood Hits	26
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

FGFR1_MOUSE
NC score	0.050388 (rank : 409)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	228	Target Neighborhood Hits	1068	Shared Neighborhood Hits	28
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.050343 (rank : 410)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	228	Target Neighborhood Hits	1069	Shared Neighborhood Hits	28
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR2_HUMAN
NC score	0.050335 (rank : 411)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	228	Target Neighborhood Hits	1062	Shared Neighborhood Hits	28
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

SOCS3_HUMAN
NC score	0.050280 (rank : 412)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	228	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

ABI1_HUMAN
NC score	0.050277 (rank : 413)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	228	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CHIO_HUMAN
NC score	0.050262 (rank : 414)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	38
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

VGFR3_HUMAN
NC score	0.050242 (rank : 415)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	228	Target Neighborhood Hits	1037	Shared Neighborhood Hits	28
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CBP_MOUSE
NC score	0.050170 (rank : 416)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	228	Target Neighborhood Hits	1051	Shared Neighborhood Hits	70
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

ARHG6_MOUSE
NC score	0.050079 (rank : 417)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	228	Target Neighborhood Hits	394	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

EPHA7_HUMAN
NC score	0.050078 (rank : 418)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	228	Target Neighborhood Hits	1053	Shared Neighborhood Hits	32
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

TEX14_MOUSE
NC score	0.050064 (rank : 419)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	228	Target Neighborhood Hits	1333	Shared Neighborhood Hits	49
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

EPHA7_MOUSE
NC score	0.050056 (rank : 420)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	228	Target Neighborhood Hits	1025	Shared Neighborhood Hits	32
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

PACN2_HUMAN
NC score	0.050032 (rank : 421)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	228	Target Neighborhood Hits	339	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

IF4B_MOUSE
NC score	0.048231 (rank : 422)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	228	Target Neighborhood Hits	368	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

ENAH_MOUSE
NC score	0.047994 (rank : 423)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	228	Target Neighborhood Hits	919	Shared Neighborhood Hits	52
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

CCDC9_HUMAN
NC score	0.047697 (rank : 424)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	228	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

SIA7A_HUMAN
NC score	0.047596 (rank : 425)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	228	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

K1219_HUMAN
NC score	0.047041 (rank : 426)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	14
SwissProt Accessions	Q86X10, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9	Gene names	KIAA1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

BPTF_HUMAN
NC score	0.046672 (rank : 427)	θ value	8.99809 (rank : 208)
Query Neighborhood Hits	228	Target Neighborhood Hits	786	Shared Neighborhood Hits	44
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

MILK1_MOUSE
NC score	0.046666 (rank : 428)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	228	Target Neighborhood Hits	788	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

CD2L5_MOUSE
NC score	0.045151 (rank : 429)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	228	Target Neighborhood Hits	1011	Shared Neighborhood Hits	48
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L5_HUMAN
NC score	0.044359 (rank : 430)	θ value	0.0330416 (rank : 27)
Query Neighborhood Hits	228	Target Neighborhood Hits	987	Shared Neighborhood Hits	39
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

SNP29_HUMAN
NC score	0.043449 (rank : 431)	θ value	5.27518 (rank : 183)
Query Neighborhood Hits	228	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	O95721	Gene names	SNAP29
Domain Architecture
Description	Synaptosomal-associated protein 29 (SNAP-29) (Vesicle-membrane fusion protein SNAP-29) (Soluble 29 kDa NSF attachment protein).

ULK1_MOUSE
NC score	0.043376 (rank : 432)	θ value	3.0926 (rank : 151)
Query Neighborhood Hits	228	Target Neighborhood Hits	1214	Shared Neighborhood Hits	63
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ZO1_HUMAN
NC score	0.042744 (rank : 433)	θ value	4.03905 (rank : 169)
Query Neighborhood Hits	228	Target Neighborhood Hits	474	Shared Neighborhood Hits	37
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

K1949_MOUSE
NC score	0.042729 (rank : 434)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	228	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

K1219_MOUSE
NC score	0.042695 (rank : 435)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	228	Target Neighborhood Hits	67	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BQZ4, Q80TH5, Q8BQN1	Gene names	Kiaa1219
Domain Architecture	No domain graphic available
Description	Protein KIAA1219.

LPP_HUMAN
NC score	0.042353 (rank : 436)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	228	Target Neighborhood Hits	775	Shared Neighborhood Hits	59
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

NFH_HUMAN
NC score	0.041932 (rank : 437)	θ value	0.365318 (rank : 65)
Query Neighborhood Hits	228	Target Neighborhood Hits	1242	Shared Neighborhood Hits	65
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

MAP2_HUMAN
NC score	0.041746 (rank : 438)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	228	Target Neighborhood Hits	348	Shared Neighborhood Hits	31
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

SOS2_HUMAN
NC score	0.041536 (rank : 439)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	228	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

RPGF5_HUMAN
NC score	0.041501 (rank : 440)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	228	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

SETBP_HUMAN
NC score	0.041335 (rank : 441)	θ value	4.03905 (rank : 165)
Query Neighborhood Hits	228	Target Neighborhood Hits	305	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

CCD1A_HUMAN
NC score	0.041225 (rank : 442)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	228	Target Neighborhood Hits	123	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P1N0, Q7Z435, Q86XV0, Q8NF89, Q9H603, Q9NXI1	Gene names	CC2D1A
Domain Architecture	No domain graphic available
Description	Coiled-coil and C2 domain-containing protein 1A (Five repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B- activating protein 023N).

GLU2B_HUMAN
NC score	0.041152 (rank : 443)	θ value	4.03905 (rank : 159)
Query Neighborhood Hits	228	Target Neighborhood Hits	377	Shared Neighborhood Hits	19
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

CK024_MOUSE
NC score	0.040861 (rank : 444)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	228	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

BRD2_HUMAN
NC score	0.040411 (rank : 445)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	228	Target Neighborhood Hits	242	Shared Neighborhood Hits	14
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

TSH1_MOUSE
NC score	0.040373 (rank : 446)	θ value	0.0961366 (rank : 47)
Query Neighborhood Hits	228	Target Neighborhood Hits	675	Shared Neighborhood Hits	26
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

RPGF5_MOUSE
NC score	0.039817 (rank : 447)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	228	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

BRDT_HUMAN
NC score	0.039739 (rank : 448)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	228	Target Neighborhood Hits	280	Shared Neighborhood Hits	17
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

REPS2_HUMAN
NC score	0.039357 (rank : 449)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	228	Target Neighborhood Hits	131	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ZAN_HUMAN
NC score	0.038784 (rank : 450)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	228	Target Neighborhood Hits	679	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

TTBK1_HUMAN
NC score	0.038685 (rank : 451)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	228	Target Neighborhood Hits	1058	Shared Neighborhood Hits	52
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

MYLK_MOUSE
NC score	0.037948 (rank : 452)	θ value	4.03905 (rank : 162)
Query Neighborhood Hits	228	Target Neighborhood Hits	1489	Shared Neighborhood Hits	63
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

GNAS1_MOUSE
NC score	0.036932 (rank : 453)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	228	Target Neighborhood Hits	651	Shared Neighborhood Hits	50
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

GAB2_MOUSE
NC score	0.036921 (rank : 454)	θ value	8.99809 (rank : 210)
Query Neighborhood Hits	228	Target Neighborhood Hits	220	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

NUCL_MOUSE
NC score	0.036769 (rank : 455)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	228	Target Neighborhood Hits	425	Shared Neighborhood Hits	18
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

GLU2B_MOUSE
NC score	0.036623 (rank : 456)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	228	Target Neighborhood Hits	357	Shared Neighborhood Hits	15
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

ZO1_MOUSE
NC score	0.034029 (rank : 457)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	228	Target Neighborhood Hits	453	Shared Neighborhood Hits	27
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

K0256_MOUSE
NC score	0.033751 (rank : 458)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	228	Target Neighborhood Hits	121	Shared Neighborhood Hits	10
SwissProt Accessions	Q6A098	Gene names	Kiaa0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

BAZ2B_HUMAN
NC score	0.032941 (rank : 459)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	228	Target Neighborhood Hits	803	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

NOP14_MOUSE
NC score	0.032848 (rank : 460)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	228	Target Neighborhood Hits	324	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R3N1	Gene names	Nop14
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

ORC2_MOUSE
NC score	0.032196 (rank : 461)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	228	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q60862	Gene names	Orc2l, Orc2
Domain Architecture
Description	Origin recognition complex subunit 2.

PAK4_MOUSE
NC score	0.032171 (rank : 462)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	228	Target Neighborhood Hits	1098	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

M4K1_HUMAN
NC score	0.032158 (rank : 463)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	228	Target Neighborhood Hits	884	Shared Neighborhood Hits	32
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

ROBO1_HUMAN
NC score	0.031873 (rank : 464)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	228	Target Neighborhood Hits	529	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

MUC5B_HUMAN
NC score	0.031653 (rank : 465)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	228	Target Neighborhood Hits	1020	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

ROBO1_MOUSE
NC score	0.031337 (rank : 466)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	228	Target Neighborhood Hits	559	Shared Neighborhood Hits	11
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

HGS_MOUSE
NC score	0.031324 (rank : 467)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	228	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

MYT1_MOUSE
NC score	0.030557 (rank : 468)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	228	Target Neighborhood Hits	385	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

PALM_HUMAN
NC score	0.030464 (rank : 469)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	228	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	O75781, O43359, O95673, Q92559, Q9UPJ4, Q9UQS2, Q9UQS3	Gene names	PALM, KIAA0270
Domain Architecture
Description	Paralemmin.

COIA1_HUMAN
NC score	0.030055 (rank : 470)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	228	Target Neighborhood Hits	447	Shared Neighborhood Hits	29
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

E2AK4_HUMAN
NC score	0.029724 (rank : 471)	θ value	5.27518 (rank : 175)
Query Neighborhood Hits	228	Target Neighborhood Hits	1012	Shared Neighborhood Hits	34
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

NKTR_MOUSE
NC score	0.028557 (rank : 472)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	228	Target Neighborhood Hits	417	Shared Neighborhood Hits	25
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

RHG25_MOUSE
NC score	0.028428 (rank : 473)	θ value	4.03905 (rank : 164)
Query Neighborhood Hits	228	Target Neighborhood Hits	492	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TTF2_MOUSE
NC score	0.027935 (rank : 474)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	228	Target Neighborhood Hits	364	Shared Neighborhood Hits	28
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

ZC11A_HUMAN
NC score	0.027840 (rank : 475)	θ value	3.0926 (rank : 153)
Query Neighborhood Hits	228	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	O75152, Q6AHY4, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7	Gene names	ZC3H11A, KIAA0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

ATX7_MOUSE
NC score	0.027759 (rank : 476)	θ value	8.99809 (rank : 207)
Query Neighborhood Hits	228	Target Neighborhood Hits	328	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

RTN1_MOUSE
NC score	0.027418 (rank : 477)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	228	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

RGP1_MOUSE
NC score	0.027411 (rank : 478)	θ value	4.03905 (rank : 163)
Query Neighborhood Hits	228	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

ANX11_HUMAN
NC score	0.025718 (rank : 479)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	228	Target Neighborhood Hits	192	Shared Neighborhood Hits	15
SwissProt Accessions	P50995	Gene names	ANXA11, ANX11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50) (56 kDa autoantigen).

DOCK4_HUMAN
NC score	0.025649 (rank : 480)	θ value	5.27518 (rank : 174)
Query Neighborhood Hits	228	Target Neighborhood Hits	237	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

BCCIP_HUMAN
NC score	0.025360 (rank : 481)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	228	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P287, Q8ND15, Q96GC4, Q9P288	Gene names	BCCIP, TOK1
Domain Architecture	No domain graphic available
Description	BRCA2 and CDKN1A-interacting protein (Protein TOK-1).

RFIP5_MOUSE
NC score	0.025244 (rank : 482)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	228	Target Neighborhood Hits	126	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

MAML1_HUMAN
NC score	0.024511 (rank : 483)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	228	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

UBP42_HUMAN
NC score	0.022703 (rank : 484)	θ value	3.0926 (rank : 150)
Query Neighborhood Hits	228	Target Neighborhood Hits	445	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

TTLL5_HUMAN
NC score	0.022334 (rank : 485)	θ value	4.03905 (rank : 167)
Query Neighborhood Hits	228	Target Neighborhood Hits	141	Shared Neighborhood Hits	11
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

NUCL_HUMAN
NC score	0.021673 (rank : 486)	θ value	5.27518 (rank : 180)
Query Neighborhood Hits	228	Target Neighborhood Hits	415	Shared Neighborhood Hits	21
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

MYT1L_HUMAN
NC score	0.021490 (rank : 487)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	228	Target Neighborhood Hits	471	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

RFIP3_HUMAN
NC score	0.020868 (rank : 488)	θ value	5.27518 (rank : 181)
Query Neighborhood Hits	228	Target Neighborhood Hits	1055	Shared Neighborhood Hits	46
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

NFM_HUMAN
NC score	0.020705 (rank : 489)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	228	Target Neighborhood Hits	1328	Shared Neighborhood Hits	64
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

OSBL8_HUMAN
NC score	0.020577 (rank : 490)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	228	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

REXO1_MOUSE
NC score	0.019896 (rank : 491)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	228	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

ZN217_HUMAN
NC score	0.019566 (rank : 492)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	228	Target Neighborhood Hits	905	Shared Neighborhood Hits	34
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

TTLL5_MOUSE
NC score	0.018761 (rank : 493)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	228	Target Neighborhood Hits	150	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

TNNT2_HUMAN
NC score	0.018388 (rank : 494)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	228	Target Neighborhood Hits	433	Shared Neighborhood Hits	10
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

MYO10_HUMAN
NC score	0.017920 (rank : 495)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	228	Target Neighborhood Hits	920	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

SYN2_MOUSE
NC score	0.016927 (rank : 496)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	228	Target Neighborhood Hits	183	Shared Neighborhood Hits	24
SwissProt Accessions	Q64332, Q6NZR0, Q9QWV7	Gene names	Syn2
Domain Architecture	No domain graphic available
Description	Synapsin-2 (Synapsin II).

CCNH_MOUSE
NC score	0.015922 (rank : 497)	θ value	8.99809 (rank : 209)
Query Neighborhood Hits	228	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q61458, Q9CVJ0, Q9JHV7	Gene names	Ccnh
Domain Architecture
Description	Cyclin-H.

TRUA_MOUSE
NC score	0.015708 (rank : 498)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	228	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WU56, Q8C250, Q8VDQ3	Gene names	Pus1
Domain Architecture
Description	tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I).

CO5A1_MOUSE
NC score	0.015250 (rank : 499)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	228	Target Neighborhood Hits	419	Shared Neighborhood Hits	23
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

GORS2_HUMAN
NC score	0.014745 (rank : 500)	θ value	8.99809 (rank : 211)
Query Neighborhood Hits	228	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

INVS_MOUSE
NC score	0.014712 (rank : 501)	θ value	5.27518 (rank : 176)
Query Neighborhood Hits	228	Target Neighborhood Hits	609	Shared Neighborhood Hits	32
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

TF3C2_MOUSE
NC score	0.014530 (rank : 502)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	228	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

CAH9_HUMAN
NC score	0.014122 (rank : 503)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	228	Target Neighborhood Hits	70	Shared Neighborhood Hits	5
SwissProt Accessions	Q16790	Gene names	CA9, G250, MN
Domain Architecture
Description	Carbonic anhydrase 9 precursor (EC 4.2.1.1) (Carbonic anhydrase IX) (Carbonate dehydratase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC- associated antigen G250) (pMW1).

TNNT3_HUMAN
NC score	0.013986 (rank : 504)	θ value	6.88961 (rank : 203)
Query Neighborhood Hits	228	Target Neighborhood Hits	327	Shared Neighborhood Hits	8
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

ZEP2_MOUSE
NC score	0.011619 (rank : 505)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	228	Target Neighborhood Hits	964	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

SYT9_MOUSE
NC score	0.011208 (rank : 506)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	228	Target Neighborhood Hits	148	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

K0423_MOUSE
NC score	0.010974 (rank : 507)	θ value	8.99809 (rank : 213)
Query Neighborhood Hits	228	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

USP9X_MOUSE
NC score	0.010925 (rank : 508)	θ value	5.27518 (rank : 188)
Query Neighborhood Hits	228	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

ZEP2_HUMAN
NC score	0.010632 (rank : 509)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	228	Target Neighborhood Hits	937	Shared Neighborhood Hits	30
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

KI13A_MOUSE
NC score	0.010239 (rank : 510)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	228	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQW7, O35062	Gene names	Kif13a
Domain Architecture
Description	Kinesin-like protein KIF13A.

H6ST3_MOUSE
NC score	0.009312 (rank : 511)	θ value	8.99809 (rank : 212)
Query Neighborhood Hits	228	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYK4	Gene names	Hs6st3
Domain Architecture	No domain graphic available
Description	Heparan-sulfate 6-O-sulfotransferase 3 (EC 2.8.2.-) (HS6ST-3) (mHS6ST- 3).

MMP24_MOUSE
NC score	0.008513 (rank : 512)	θ value	6.88961 (rank : 198)
Query Neighborhood Hits	228	Target Neighborhood Hits	71	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

ETV1_HUMAN
NC score	0.006636 (rank : 513)	θ value	6.88961 (rank : 194)
Query Neighborhood Hits	228	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	P50549, O75849, Q9UQ71, Q9Y636	Gene names	ETV1, ER81
Domain Architecture
Description	ETS translocation variant 1 (ER81 protein).

NALP1_HUMAN
NC score	0.006173 (rank : 514)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	228	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

TRI55_HUMAN
NC score	0.006036 (rank : 515)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	228	Target Neighborhood Hits	292	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

DMD_MOUSE
NC score	0.005129 (rank : 516)	θ value	5.27518 (rank : 173)
Query Neighborhood Hits	228	Target Neighborhood Hits	1111	Shared Neighborhood Hits	26
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

LRP2_HUMAN
NC score	0.004838 (rank : 517)	θ value	4.03905 (rank : 161)
Query Neighborhood Hits	228	Target Neighborhood Hits	573	Shared Neighborhood Hits	7
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

KAISO_MOUSE
NC score	0.004227 (rank : 518)	θ value	4.03905 (rank : 160)
Query Neighborhood Hits	228	Target Neighborhood Hits	821	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BN78, Q8C226, Q9WTZ7	Gene names	Zbtb33, Kaiso
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

DLX2_HUMAN
NC score	0.003656 (rank : 519)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	228	Target Neighborhood Hits	355	Shared Neighborhood Hits	3
SwissProt Accessions	Q07687	Gene names	DLX2
Domain Architecture
Description	Homeobox protein DLX-2.

FBLN2_HUMAN
NC score	0.003468 (rank : 520)	θ value	6.88961 (rank : 195)
Query Neighborhood Hits	228	Target Neighborhood Hits	392	Shared Neighborhood Hits	12
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

DLX2_MOUSE
NC score	0.003175 (rank : 521)	θ value	6.88961 (rank : 193)
Query Neighborhood Hits	228	Target Neighborhood Hits	352	Shared Neighborhood Hits	3
SwissProt Accessions	P40764	Gene names	Dlx2, Tes-1, Tes1
Domain Architecture
Description	Homeobox protein DLX-2 (Homeobox protein TES-1).

KAISO_HUMAN
NC score	0.003079 (rank : 522)	θ value	5.27518 (rank : 177)
Query Neighborhood Hits	228	Target Neighborhood Hits	840	Shared Neighborhood Hits	15
SwissProt Accessions	Q86T24, O00319, Q7Z361, Q8IVP6, Q8N3P0	Gene names	ZBTB33, KAISO, ZNF348
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

ZN509_MOUSE
NC score	0.002232 (rank : 523)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	228	Target Neighborhood Hits	990	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

ZF276_MOUSE
NC score	0.000322 (rank : 524)	θ value	5.27518 (rank : 190)
Query Neighborhood Hits	228	Target Neighborhood Hits	745	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CE64, Q9ESV2	Gene names	Zfp276
Domain Architecture	No domain graphic available
Description	Zinc finger protein 276 (Zfp-276).