Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : ZO1_MOUSE

For an explanation of this page, click here

ZO1_MOUSE
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ZO1_HUMAN
θ value	0 (rank : 1)	NC score	0.975693 (rank : 2)
Query Neighborhood Hits	453	Target Neighborhood Hits	474	Shared Neighborhood Hits	280
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	453	Target Neighborhood Hits	453	Shared Neighborhood Hits	453
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_HUMAN
θ value	0 (rank : 3)	NC score	0.915294 (rank : 5)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	185
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	0 (rank : 4)	NC score	0.919141 (rank : 4)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO3_HUMAN
θ value	9.45368e-175 (rank : 5)	NC score	0.919726 (rank : 3)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	183
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	6.35588e-163 (rank : 6)	NC score	0.915270 (rank : 6)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	184
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

DLG5_HUMAN
θ value	3.27365e-34 (rank : 7)	NC score	0.532698 (rank : 34)
Query Neighborhood Hits	453	Target Neighborhood Hits	1088	Shared Neighborhood Hits	204
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DLG1_MOUSE
θ value	1.6247e-33 (rank : 8)	NC score	0.715810 (rank : 12)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	169
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_HUMAN
θ value	2.12192e-33 (rank : 9)	NC score	0.718466 (rank : 9)
Query Neighborhood Hits	453	Target Neighborhood Hits	279	Shared Neighborhood Hits	173
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG1_HUMAN
θ value	6.17384e-33 (rank : 10)	NC score	0.714635 (rank : 14)
Query Neighborhood Hits	453	Target Neighborhood Hits	290	Shared Neighborhood Hits	171
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG2_MOUSE
θ value	1.0531e-32 (rank : 11)	NC score	0.718309 (rank : 10)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	171
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_MOUSE
θ value	3.06405e-32 (rank : 12)	NC score	0.724002 (rank : 7)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	176
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
θ value	4.00176e-32 (rank : 13)	NC score	0.723182 (rank : 8)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	176
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG3_HUMAN
θ value	6.82597e-32 (rank : 14)	NC score	0.716147 (rank : 11)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	172
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	3.74554e-30 (rank : 15)	NC score	0.714854 (rank : 13)
Query Neighborhood Hits	453	Target Neighborhood Hits	274	Shared Neighborhood Hits	172
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

INADL_MOUSE
θ value	8.65492e-19 (rank : 16)	NC score	0.643223 (rank : 16)
Query Neighborhood Hits	453	Target Neighborhood Hits	290	Shared Neighborhood Hits	186
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

INADL_HUMAN
θ value	3.63628e-17 (rank : 17)	NC score	0.626397 (rank : 17)
Query Neighborhood Hits	453	Target Neighborhood Hits	260	Shared Neighborhood Hits	176
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

PTN13_MOUSE
θ value	3.07829e-16 (rank : 18)	NC score	0.360473 (rank : 97)
Query Neighborhood Hits	453	Target Neighborhood Hits	426	Shared Neighborhood Hits	173
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

UNC5C_HUMAN
θ value	1.68911e-14 (rank : 19)	NC score	0.215801 (rank : 151)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	19
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	1.68911e-14 (rank : 20)	NC score	0.216022 (rank : 150)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

MPDZ_HUMAN
θ value	4.91457e-14 (rank : 21)	NC score	0.607007 (rank : 19)
Query Neighborhood Hits	453	Target Neighborhood Hits	261	Shared Neighborhood Hits	180
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPP5_MOUSE
θ value	6.41864e-14 (rank : 22)	NC score	0.530498 (rank : 41)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPDZ_MOUSE
θ value	1.09485e-13 (rank : 23)	NC score	0.607698 (rank : 18)
Query Neighborhood Hits	453	Target Neighborhood Hits	298	Shared Neighborhood Hits	184
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MPP5_HUMAN
θ value	1.42992e-13 (rank : 24)	NC score	0.531314 (rank : 36)
Query Neighborhood Hits	453	Target Neighborhood Hits	231	Shared Neighborhood Hits	132
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

UNC5B_MOUSE
θ value	2.0648e-12 (rank : 25)	NC score	0.211627 (rank : 153)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5B_HUMAN
θ value	2.69671e-12 (rank : 26)	NC score	0.210536 (rank : 154)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

LAP4_HUMAN
θ value	4.59992e-12 (rank : 27)	NC score	0.410018 (rank : 84)
Query Neighborhood Hits	453	Target Neighborhood Hits	608	Shared Neighborhood Hits	202
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
θ value	6.00763e-12 (rank : 28)	NC score	0.406765 (rank : 87)
Query Neighborhood Hits	453	Target Neighborhood Hits	590	Shared Neighborhood Hits	197
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PTN13_HUMAN
θ value	1.02475e-11 (rank : 29)	NC score	0.364484 (rank : 94)
Query Neighborhood Hits	453	Target Neighborhood Hits	471	Shared Neighborhood Hits	178
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

MAGI1_HUMAN
θ value	1.74796e-11 (rank : 30)	NC score	0.530096 (rank : 42)
Query Neighborhood Hits	453	Target Neighborhood Hits	388	Shared Neighborhood Hits	197
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

UNC5D_MOUSE
θ value	1.74796e-11 (rank : 31)	NC score	0.200765 (rank : 159)
Query Neighborhood Hits	453	Target Neighborhood Hits	268	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

LNX2_MOUSE
θ value	6.64225e-11 (rank : 32)	NC score	0.558344 (rank : 24)
Query Neighborhood Hits	453	Target Neighborhood Hits	407	Shared Neighborhood Hits	173
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

UNC5A_MOUSE
θ value	8.67504e-11 (rank : 33)	NC score	0.204842 (rank : 158)
Query Neighborhood Hits	453	Target Neighborhood Hits	203	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5D_HUMAN
θ value	1.133e-10 (rank : 34)	NC score	0.199299 (rank : 160)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

PDZD2_HUMAN
θ value	1.47974e-10 (rank : 35)	NC score	0.562017 (rank : 23)
Query Neighborhood Hits	453	Target Neighborhood Hits	772	Shared Neighborhood Hits	222
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

UNC5A_HUMAN
θ value	1.47974e-10 (rank : 36)	NC score	0.226119 (rank : 145)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	15
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

MAGI1_MOUSE
θ value	2.52405e-10 (rank : 37)	NC score	0.525584 (rank : 47)
Query Neighborhood Hits	453	Target Neighborhood Hits	403	Shared Neighborhood Hits	200
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PZRN3_HUMAN
θ value	1.63604e-09 (rank : 38)	NC score	0.491863 (rank : 60)
Query Neighborhood Hits	453	Target Neighborhood Hits	461	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	1.63604e-09 (rank : 39)	NC score	0.490479 (rank : 61)
Query Neighborhood Hits	453	Target Neighborhood Hits	447	Shared Neighborhood Hits	155
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

EM55_MOUSE
θ value	2.79066e-09 (rank : 40)	NC score	0.445569 (rank : 73)
Query Neighborhood Hits	453	Target Neighborhood Hits	221	Shared Neighborhood Hits	114
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

LNX2_HUMAN
θ value	3.64472e-09 (rank : 41)	NC score	0.541510 (rank : 30)
Query Neighborhood Hits	453	Target Neighborhood Hits	389	Shared Neighborhood Hits	170
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

USH1C_HUMAN
θ value	4.76016e-09 (rank : 42)	NC score	0.572107 (rank : 22)
Query Neighborhood Hits	453	Target Neighborhood Hits	327	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PZRN4_HUMAN
θ value	1.38499e-08 (rank : 43)	NC score	0.493246 (rank : 59)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	153
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LNX1_HUMAN
θ value	1.80886e-08 (rank : 44)	NC score	0.540485 (rank : 31)
Query Neighborhood Hits	453	Target Neighborhood Hits	379	Shared Neighborhood Hits	158
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

CAR11_HUMAN
θ value	4.0297e-08 (rank : 45)	NC score	0.225198 (rank : 146)
Query Neighborhood Hits	453	Target Neighborhood Hits	690	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_MOUSE
θ value	4.0297e-08 (rank : 46)	NC score	0.218022 (rank : 148)
Query Neighborhood Hits	453	Target Neighborhood Hits	526	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

MAGI2_MOUSE
θ value	4.0297e-08 (rank : 47)	NC score	0.510324 (rank : 52)
Query Neighborhood Hits	453	Target Neighborhood Hits	370	Shared Neighborhood Hits	189
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

LNX1_MOUSE
θ value	8.97725e-08 (rank : 48)	NC score	0.546004 (rank : 28)
Query Neighborhood Hits	453	Target Neighborhood Hits	377	Shared Neighborhood Hits	167
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

CAR14_HUMAN
θ value	1.99992e-07 (rank : 49)	NC score	0.246740 (rank : 135)
Query Neighborhood Hits	453	Target Neighborhood Hits	449	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

PDZ11_MOUSE
θ value	2.61198e-07 (rank : 50)	NC score	0.596319 (rank : 20)
Query Neighborhood Hits	453	Target Neighborhood Hits	154	Shared Neighborhood Hits	136
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_HUMAN
θ value	5.81887e-07 (rank : 51)	NC score	0.595170 (rank : 21)
Query Neighborhood Hits	453	Target Neighborhood Hits	160	Shared Neighborhood Hits	140
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

SNTA1_HUMAN
θ value	9.92553e-07 (rank : 52)	NC score	0.477284 (rank : 66)
Query Neighborhood Hits	453	Target Neighborhood Hits	186	Shared Neighborhood Hits	154
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTG2_HUMAN
θ value	9.92553e-07 (rank : 53)	NC score	0.507835 (rank : 54)
Query Neighborhood Hits	453	Target Neighborhood Hits	191	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SYJ2B_HUMAN
θ value	1.29631e-06 (rank : 54)	NC score	0.649357 (rank : 15)
Query Neighborhood Hits	453	Target Neighborhood Hits	162	Shared Neighborhood Hits	148
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

MAGI2_HUMAN
θ value	1.69304e-06 (rank : 55)	NC score	0.503015 (rank : 55)
Query Neighborhood Hits	453	Target Neighborhood Hits	373	Shared Neighborhood Hits	188
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SNTA1_MOUSE
θ value	1.69304e-06 (rank : 56)	NC score	0.472930 (rank : 67)
Query Neighborhood Hits	453	Target Neighborhood Hits	170	Shared Neighborhood Hits	148
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTG2_MOUSE
θ value	1.69304e-06 (rank : 57)	NC score	0.481436 (rank : 64)
Query Neighborhood Hits	453	Target Neighborhood Hits	176	Shared Neighborhood Hits	149
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

CAR10_MOUSE
θ value	2.21117e-06 (rank : 58)	NC score	0.206585 (rank : 155)
Query Neighborhood Hits	453	Target Neighborhood Hits	407	Shared Neighborhood Hits	29
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

EM55_HUMAN
θ value	2.21117e-06 (rank : 59)	NC score	0.436352 (rank : 77)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	116
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

PAR3L_HUMAN
θ value	3.77169e-06 (rank : 60)	NC score	0.530881 (rank : 39)
Query Neighborhood Hits	453	Target Neighborhood Hits	297	Shared Neighborhood Hits	152
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

WHRN_MOUSE
θ value	3.77169e-06 (rank : 61)	NC score	0.553055 (rank : 26)
Query Neighborhood Hits	453	Target Neighborhood Hits	412	Shared Neighborhood Hits	192
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

LRRC7_HUMAN
θ value	4.92598e-06 (rank : 62)	NC score	0.246326 (rank : 136)
Query Neighborhood Hits	453	Target Neighborhood Hits	423	Shared Neighborhood Hits	124
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	4.92598e-06 (rank : 63)	NC score	0.245781 (rank : 137)
Query Neighborhood Hits	453	Target Neighborhood Hits	416	Shared Neighborhood Hits	125
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

USH1C_MOUSE
θ value	6.43352e-06 (rank : 64)	NC score	0.528417 (rank : 44)
Query Neighborhood Hits	453	Target Neighborhood Hits	557	Shared Neighborhood Hits	201
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

WHRN_HUMAN
θ value	6.43352e-06 (rank : 65)	NC score	0.558326 (rank : 25)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	190
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

LAP2_HUMAN
θ value	1.43324e-05 (rank : 66)	NC score	0.237404 (rank : 140)
Query Neighborhood Hits	453	Target Neighborhood Hits	499	Shared Neighborhood Hits	126
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

MPP2_MOUSE
θ value	1.87187e-05 (rank : 67)	NC score	0.425490 (rank : 80)
Query Neighborhood Hits	453	Target Neighborhood Hits	189	Shared Neighborhood Hits	98
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

PDZK4_HUMAN
θ value	2.44474e-05 (rank : 68)	NC score	0.403510 (rank : 88)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	120
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

NHERF_MOUSE
θ value	3.19293e-05 (rank : 69)	NC score	0.450796 (rank : 72)
Query Neighborhood Hits	453	Target Neighborhood Hits	195	Shared Neighborhood Hits	151
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD1_MOUSE
θ value	3.19293e-05 (rank : 70)	NC score	0.499318 (rank : 58)
Query Neighborhood Hits	453	Target Neighborhood Hits	191	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

GRIP2_HUMAN
θ value	4.1701e-05 (rank : 71)	NC score	0.544239 (rank : 29)
Query Neighborhood Hits	453	Target Neighborhood Hits	256	Shared Neighborhood Hits	175
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LAP2_MOUSE
θ value	4.1701e-05 (rank : 72)	NC score	0.229251 (rank : 143)
Query Neighborhood Hits	453	Target Neighborhood Hits	482	Shared Neighborhood Hits	117
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

SNTB1_MOUSE
θ value	4.1701e-05 (rank : 73)	NC score	0.458317 (rank : 71)
Query Neighborhood Hits	453	Target Neighborhood Hits	160	Shared Neighborhood Hits	136
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

TXND2_HUMAN
θ value	4.1701e-05 (rank : 74)	NC score	0.092797 (rank : 200)
Query Neighborhood Hits	453	Target Neighborhood Hits	793	Shared Neighborhood Hits	99
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ARHGC_HUMAN
θ value	5.44631e-05 (rank : 75)	NC score	0.253455 (rank : 130)
Query Neighborhood Hits	453	Target Neighborhood Hits	351	Shared Neighborhood Hits	143
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

IL16_HUMAN
θ value	5.44631e-05 (rank : 76)	NC score	0.526629 (rank : 46)
Query Neighborhood Hits	453	Target Neighborhood Hits	207	Shared Neighborhood Hits	147
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SNTG1_MOUSE
θ value	5.44631e-05 (rank : 77)	NC score	0.462923 (rank : 68)
Query Neighborhood Hits	453	Target Neighborhood Hits	179	Shared Neighborhood Hits	152
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

NEB2_HUMAN
θ value	7.1131e-05 (rank : 78)	NC score	0.337741 (rank : 107)
Query Neighborhood Hits	453	Target Neighborhood Hits	883	Shared Neighborhood Hits	142
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	7.1131e-05 (rank : 79)	NC score	0.333055 (rank : 108)
Query Neighborhood Hits	453	Target Neighborhood Hits	889	Shared Neighborhood Hits	138
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PDZK4_MOUSE
θ value	7.1131e-05 (rank : 80)	NC score	0.400499 (rank : 89)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

GRIP1_HUMAN
θ value	9.29e-05 (rank : 81)	NC score	0.535923 (rank : 32)
Query Neighborhood Hits	453	Target Neighborhood Hits	231	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

MPP2_HUMAN
θ value	9.29e-05 (rank : 82)	NC score	0.422020 (rank : 81)
Query Neighborhood Hits	453	Target Neighborhood Hits	173	Shared Neighborhood Hits	90
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

SNTG1_HUMAN
θ value	9.29e-05 (rank : 83)	NC score	0.462899 (rank : 69)
Query Neighborhood Hits	453	Target Neighborhood Hits	181	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

CSKP_HUMAN
θ value	0.000121331 (rank : 84)	NC score	0.146041 (rank : 180)
Query Neighborhood Hits	453	Target Neighborhood Hits	1022	Shared Neighborhood Hits	123
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

GOPC_HUMAN
θ value	0.000121331 (rank : 85)	NC score	0.502128 (rank : 57)
Query Neighborhood Hits	453	Target Neighborhood Hits	377	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.000121331 (rank : 86)	NC score	0.511054 (rank : 51)
Query Neighborhood Hits	453	Target Neighborhood Hits	323	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GRIP1_MOUSE
θ value	0.000121331 (rank : 87)	NC score	0.533532 (rank : 33)
Query Neighborhood Hits	453	Target Neighborhood Hits	241	Shared Neighborhood Hits	179
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

MPP6_HUMAN
θ value	0.000121331 (rank : 88)	NC score	0.415409 (rank : 82)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SNTB1_HUMAN
θ value	0.000158464 (rank : 89)	NC score	0.459130 (rank : 70)
Query Neighborhood Hits	453	Target Neighborhood Hits	157	Shared Neighborhood Hits	138
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

CAR10_HUMAN
θ value	0.000270298 (rank : 90)	NC score	0.168677 (rank : 172)
Query Neighborhood Hits	453	Target Neighborhood Hits	569	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

ARHGC_MOUSE
θ value	0.000461057 (rank : 91)	NC score	0.248302 (rank : 134)
Query Neighborhood Hits	453	Target Neighborhood Hits	344	Shared Neighborhood Hits	144
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

NEB1_HUMAN
θ value	0.000461057 (rank : 92)	NC score	0.345654 (rank : 105)
Query Neighborhood Hits	453	Target Neighborhood Hits	829	Shared Neighborhood Hits	139
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

MPP3_HUMAN
θ value	0.000602161 (rank : 93)	NC score	0.443988 (rank : 74)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	121
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PRAX_MOUSE
θ value	0.000602161 (rank : 94)	NC score	0.199241 (rank : 161)
Query Neighborhood Hits	453	Target Neighborhood Hits	199	Shared Neighborhood Hits	62
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

ARI1A_HUMAN
θ value	0.000786445 (rank : 95)	NC score	0.072870 (rank : 208)
Query Neighborhood Hits	453	Target Neighborhood Hits	787	Shared Neighborhood Hits	101
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

K1849_HUMAN
θ value	0.000786445 (rank : 96)	NC score	0.392177 (rank : 91)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	132
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MPP3_MOUSE
θ value	0.000786445 (rank : 97)	NC score	0.439331 (rank : 76)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

PARD3_HUMAN
θ value	0.000786445 (rank : 98)	NC score	0.514787 (rank : 50)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	160
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PRAX_HUMAN
θ value	0.000786445 (rank : 99)	NC score	0.174234 (rank : 170)
Query Neighborhood Hits	453	Target Neighborhood Hits	215	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

RPGF6_HUMAN
θ value	0.000786445 (rank : 100)	NC score	0.326954 (rank : 109)
Query Neighborhood Hits	453	Target Neighborhood Hits	266	Shared Neighborhood Hits	154
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PDZD1_HUMAN
θ value	0.00102713 (rank : 101)	NC score	0.487909 (rank : 62)
Query Neighborhood Hits	453	Target Neighborhood Hits	190	Shared Neighborhood Hits	149
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MUC7_HUMAN
θ value	0.00134147 (rank : 102)	NC score	0.091042 (rank : 201)
Query Neighborhood Hits	453	Target Neighborhood Hits	538	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SNTB2_HUMAN
θ value	0.00134147 (rank : 103)	NC score	0.480501 (rank : 65)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	149
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	0.00134147 (rank : 104)	NC score	0.481568 (rank : 63)
Query Neighborhood Hits	453	Target Neighborhood Hits	181	Shared Neighborhood Hits	149
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

CD2L5_MOUSE
θ value	0.00175202 (rank : 105)	NC score	0.008292 (rank : 450)
Query Neighborhood Hits	453	Target Neighborhood Hits	1011	Shared Neighborhood Hits	49
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

DVL2_MOUSE
θ value	0.00175202 (rank : 106)	NC score	0.347842 (rank : 103)
Query Neighborhood Hits	453	Target Neighborhood Hits	233	Shared Neighborhood Hits	121
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

IL16_MOUSE
θ value	0.00175202 (rank : 107)	NC score	0.502640 (rank : 56)
Query Neighborhood Hits	453	Target Neighborhood Hits	189	Shared Neighborhood Hits	138
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

K1849_MOUSE
θ value	0.00175202 (rank : 108)	NC score	0.389732 (rank : 93)
Query Neighborhood Hits	453	Target Neighborhood Hits	335	Shared Neighborhood Hits	145
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PCLO_MOUSE
θ value	0.00175202 (rank : 109)	NC score	0.183104 (rank : 164)
Query Neighborhood Hits	453	Target Neighborhood Hits	2275	Shared Neighborhood Hits	278
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

MPP6_MOUSE
θ value	0.00228821 (rank : 110)	NC score	0.408138 (rank : 86)
Query Neighborhood Hits	453	Target Neighborhood Hits	187	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

LIN7C_HUMAN
θ value	0.00390308 (rank : 111)	NC score	0.531049 (rank : 37)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	171
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	0.00390308 (rank : 112)	NC score	0.531049 (rank : 38)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	171
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

TX1B3_HUMAN
θ value	0.00390308 (rank : 113)	NC score	0.532487 (rank : 35)
Query Neighborhood Hits	453	Target Neighborhood Hits	161	Shared Neighborhood Hits	146
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.00390308 (rank : 114)	NC score	0.529620 (rank : 43)
Query Neighborhood Hits	453	Target Neighborhood Hits	158	Shared Neighborhood Hits	143
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

APBA3_MOUSE
θ value	0.00509761 (rank : 115)	NC score	0.299612 (rank : 115)
Query Neighborhood Hits	453	Target Neighborhood Hits	174	Shared Neighborhood Hits	123
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

SVIL_MOUSE
θ value	0.00509761 (rank : 116)	NC score	0.056987 (rank : 240)
Query Neighborhood Hits	453	Target Neighborhood Hits	439	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

DVL1L_HUMAN
θ value	0.00665767 (rank : 117)	NC score	0.348922 (rank : 102)
Query Neighborhood Hits	453	Target Neighborhood Hits	146	Shared Neighborhood Hits	113
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
θ value	0.00665767 (rank : 118)	NC score	0.347573 (rank : 104)
Query Neighborhood Hits	453	Target Neighborhood Hits	223	Shared Neighborhood Hits	119
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

RPGF2_HUMAN
θ value	0.00665767 (rank : 119)	NC score	0.282954 (rank : 118)
Query Neighborhood Hits	453	Target Neighborhood Hits	242	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SDCB2_MOUSE
θ value	0.00665767 (rank : 120)	NC score	0.303396 (rank : 113)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	106
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

ARHGB_HUMAN
θ value	0.00869519 (rank : 121)	NC score	0.259522 (rank : 129)
Query Neighborhood Hits	453	Target Neighborhood Hits	375	Shared Neighborhood Hits	165
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DVL3_HUMAN
θ value	0.0113563 (rank : 122)	NC score	0.364025 (rank : 95)
Query Neighborhood Hits	453	Target Neighborhood Hits	194	Shared Neighborhood Hits	117
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.0113563 (rank : 123)	NC score	0.363867 (rank : 96)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	119
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

LIN7B_HUMAN
θ value	0.0113563 (rank : 124)	NC score	0.530803 (rank : 40)
Query Neighborhood Hits	453	Target Neighborhood Hits	200	Shared Neighborhood Hits	173
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

PDZD7_HUMAN
θ value	0.0113563 (rank : 125)	NC score	0.548297 (rank : 27)
Query Neighborhood Hits	453	Target Neighborhood Hits	181	Shared Neighborhood Hits	158
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

DVL1_HUMAN
θ value	0.0148317 (rank : 126)	NC score	0.359458 (rank : 98)
Query Neighborhood Hits	453	Target Neighborhood Hits	158	Shared Neighborhood Hits	115
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

ETV5_MOUSE
θ value	0.0148317 (rank : 127)	NC score	0.030151 (rank : 330)
Query Neighborhood Hits	453	Target Neighborhood Hits	328	Shared Neighborhood Hits	35
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

KI13A_HUMAN
θ value	0.0148317 (rank : 128)	NC score	0.010803 (rank : 429)
Query Neighborhood Hits	453	Target Neighborhood Hits	359	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H1H9, Q9H1H8	Gene names	KIF13A, RBKIN
Domain Architecture
Description	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN).

LIN7B_MOUSE
θ value	0.0148317 (rank : 129)	NC score	0.528329 (rank : 45)
Query Neighborhood Hits	453	Target Neighborhood Hits	200	Shared Neighborhood Hits	173
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

MDC1_MOUSE
θ value	0.0148317 (rank : 130)	NC score	0.084504 (rank : 203)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	127
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PARD3_MOUSE
θ value	0.0148317 (rank : 131)	NC score	0.509432 (rank : 53)
Query Neighborhood Hits	453	Target Neighborhood Hits	290	Shared Neighborhood Hits	161
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

DVL1_MOUSE
θ value	0.0193708 (rank : 132)	NC score	0.356005 (rank : 100)
Query Neighborhood Hits	453	Target Neighborhood Hits	146	Shared Neighborhood Hits	113
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

NHERF_HUMAN
θ value	0.0193708 (rank : 133)	NC score	0.427052 (rank : 79)
Query Neighborhood Hits	453	Target Neighborhood Hits	190	Shared Neighborhood Hits	153
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PRP4B_MOUSE
θ value	0.0193708 (rank : 134)	NC score	0.013531 (rank : 404)
Query Neighborhood Hits	453	Target Neighborhood Hits	1040	Shared Neighborhood Hits	49
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

LIN7A_HUMAN
θ value	0.0252991 (rank : 135)	NC score	0.523127 (rank : 48)
Query Neighborhood Hits	453	Target Neighborhood Hits	193	Shared Neighborhood Hits	170
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	0.0252991 (rank : 136)	NC score	0.523059 (rank : 49)
Query Neighborhood Hits	453	Target Neighborhood Hits	193	Shared Neighborhood Hits	170
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIMK2_MOUSE
θ value	0.0330416 (rank : 137)	NC score	0.032477 (rank : 317)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	77
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MILK1_HUMAN
θ value	0.0330416 (rank : 138)	NC score	0.044121 (rank : 279)
Query Neighborhood Hits	453	Target Neighborhood Hits	427	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NPAS4_MOUSE
θ value	0.0330416 (rank : 139)	NC score	0.048282 (rank : 266)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

SDCB1_MOUSE
θ value	0.0330416 (rank : 140)	NC score	0.356644 (rank : 99)
Query Neighborhood Hits	453	Target Neighborhood Hits	144	Shared Neighborhood Hits	129
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SYP2L_HUMAN
θ value	0.0330416 (rank : 141)	NC score	0.271696 (rank : 125)
Query Neighborhood Hits	453	Target Neighborhood Hits	400	Shared Neighborhood Hits	153
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

LIMK2_HUMAN
θ value	0.0431538 (rank : 142)	NC score	0.030054 (rank : 331)
Query Neighborhood Hits	453	Target Neighborhood Hits	986	Shared Neighborhood Hits	80
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CNOT4_HUMAN
θ value	0.0563607 (rank : 143)	NC score	0.047934 (rank : 270)
Query Neighborhood Hits	453	Target Neighborhood Hits	207	Shared Neighborhood Hits	20
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

MYO15_MOUSE
θ value	0.0563607 (rank : 144)	NC score	0.020734 (rank : 369)
Query Neighborhood Hits	453	Target Neighborhood Hits	467	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PDZD3_HUMAN
θ value	0.0563607 (rank : 145)	NC score	0.439926 (rank : 75)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	154
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SDCB1_HUMAN
θ value	0.0563607 (rank : 146)	NC score	0.355331 (rank : 101)
Query Neighborhood Hits	453	Target Neighborhood Hits	150	Shared Neighborhood Hits	133
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SYP2L_MOUSE
θ value	0.0563607 (rank : 147)	NC score	0.197006 (rank : 162)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

CNOT4_MOUSE
θ value	0.0736092 (rank : 148)	NC score	0.048468 (rank : 265)
Query Neighborhood Hits	453	Target Neighborhood Hits	277	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

IWS1_HUMAN
θ value	0.0736092 (rank : 149)	NC score	0.061055 (rank : 231)
Query Neighborhood Hits	453	Target Neighborhood Hits	1241	Shared Neighborhood Hits	106
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NKTR_MOUSE
θ value	0.0736092 (rank : 150)	NC score	0.035987 (rank : 306)
Query Neighborhood Hits	453	Target Neighborhood Hits	417	Shared Neighborhood Hits	55
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PDLI2_HUMAN
θ value	0.0736092 (rank : 151)	NC score	0.300542 (rank : 114)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	121
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	0.0736092 (rank : 152)	NC score	0.274523 (rank : 124)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	113
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PO121_MOUSE
θ value	0.0736092 (rank : 153)	NC score	0.045308 (rank : 274)
Query Neighborhood Hits	453	Target Neighborhood Hits	345	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

RECQ4_MOUSE
θ value	0.0736092 (rank : 154)	NC score	0.022216 (rank : 365)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

SIN3A_HUMAN
θ value	0.0736092 (rank : 155)	NC score	0.037538 (rank : 297)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	32
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

ZXDB_HUMAN
θ value	0.0736092 (rank : 156)	NC score	-0.001525 (rank : 497)
Query Neighborhood Hits	453	Target Neighborhood Hits	753	Shared Neighborhood Hits	26
SwissProt Accessions	P98169, Q9UBB3	Gene names	ZXDB
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDB.

ANK1_HUMAN
θ value	0.0961366 (rank : 157)	NC score	0.022038 (rank : 366)
Query Neighborhood Hits	453	Target Neighborhood Hits	416	Shared Neighborhood Hits	28
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

APBA3_HUMAN
θ value	0.0961366 (rank : 158)	NC score	0.281986 (rank : 121)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	129
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

IDD_MOUSE
θ value	0.0961366 (rank : 159)	NC score	0.036147 (rank : 303)
Query Neighborhood Hits	453	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

MPP4_MOUSE
θ value	0.0961366 (rank : 160)	NC score	0.391661 (rank : 92)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	110
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

NHRF2_HUMAN
θ value	0.0961366 (rank : 161)	NC score	0.427625 (rank : 78)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	162
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NKTR_HUMAN
θ value	0.0961366 (rank : 162)	NC score	0.032330 (rank : 319)
Query Neighborhood Hits	453	Target Neighborhood Hits	658	Shared Neighborhood Hits	62
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

SIN3A_MOUSE
θ value	0.0961366 (rank : 163)	NC score	0.036365 (rank : 302)
Query Neighborhood Hits	453	Target Neighborhood Hits	169	Shared Neighborhood Hits	29
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

ZBT38_HUMAN
θ value	0.0961366 (rank : 164)	NC score	0.001071 (rank : 487)
Query Neighborhood Hits	453	Target Neighborhood Hits	885	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NAP3	Gene names	ZBTB38
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 38.

ZCPW1_MOUSE
θ value	0.0961366 (rank : 165)	NC score	0.057906 (rank : 236)
Query Neighborhood Hits	453	Target Neighborhood Hits	307	Shared Neighborhood Hits	39
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

IKAR_HUMAN
θ value	0.125558 (rank : 166)	NC score	-0.000882 (rank : 494)
Query Neighborhood Hits	453	Target Neighborhood Hits	726	Shared Neighborhood Hits	22
SwissProt Accessions	Q13422, O00598, Q8WVA3	Gene names	IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Domain Architecture	No domain graphic available
Description	DNA-binding protein Ikaros (IKAROS family zinc finger protein 1) (Lymphoid transcription factor LyF-1).

MDC1_HUMAN
θ value	0.125558 (rank : 167)	NC score	0.068443 (rank : 213)
Query Neighborhood Hits	453	Target Neighborhood Hits	1446	Shared Neighborhood Hits	136
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NFH_MOUSE
θ value	0.125558 (rank : 168)	NC score	0.050513 (rank : 262)
Query Neighborhood Hits	453	Target Neighborhood Hits	2247	Shared Neighborhood Hits	177
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CB017_HUMAN
θ value	0.163984 (rank : 169)	NC score	0.032821 (rank : 314)
Query Neighborhood Hits	453	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NC44, Q6P1P5, Q9H0K7	Gene names	C2orf17
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf17.

CSKP_MOUSE
θ value	0.163984 (rank : 170)	NC score	0.134598 (rank : 187)
Query Neighborhood Hits	453	Target Neighborhood Hits	1027	Shared Neighborhood Hits	124
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

KLF5_HUMAN
θ value	0.163984 (rank : 171)	NC score	0.001121 (rank : 486)
Query Neighborhood Hits	453	Target Neighborhood Hits	727	Shared Neighborhood Hits	22
SwissProt Accessions	Q13887, Q9UHP8	Gene names	KLF5, BTEB2, CKLF, IKLF
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Colon krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2) (GC box-binding protein 2).

MAST4_HUMAN
θ value	0.163984 (rank : 172)	NC score	0.050720 (rank : 260)
Query Neighborhood Hits	453	Target Neighborhood Hits	1804	Shared Neighborhood Hits	205
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MUC2_HUMAN
θ value	0.163984 (rank : 173)	NC score	0.035132 (rank : 310)
Query Neighborhood Hits	453	Target Neighborhood Hits	906	Shared Neighborhood Hits	83
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NFIB_MOUSE
θ value	0.163984 (rank : 174)	NC score	0.040636 (rank : 286)
Query Neighborhood Hits	453	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	P97863, P70252, P70253, P70254, Q9R1G4	Gene names	Nfib
Domain Architecture
Description	Nuclear factor 1 B-type (Nuclear factor 1/B) (NF1-B) (NFI-B) (NF-I/B) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

RHPN1_MOUSE
θ value	0.163984 (rank : 175)	NC score	0.250860 (rank : 132)
Query Neighborhood Hits	453	Target Neighborhood Hits	154	Shared Neighborhood Hits	125
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

ANK1_MOUSE
θ value	0.21417 (rank : 176)	NC score	0.020594 (rank : 370)
Query Neighborhood Hits	453	Target Neighborhood Hits	430	Shared Neighborhood Hits	23
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANK3_HUMAN
θ value	0.21417 (rank : 177)	NC score	0.021346 (rank : 367)
Query Neighborhood Hits	453	Target Neighborhood Hits	853	Shared Neighborhood Hits	58
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

CJ078_MOUSE
θ value	0.21417 (rank : 178)	NC score	0.073220 (rank : 206)
Query Neighborhood Hits	453	Target Neighborhood Hits	559	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

HTRA3_HUMAN
θ value	0.21417 (rank : 179)	NC score	0.097173 (rank : 199)
Query Neighborhood Hits	453	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

MED12_HUMAN
θ value	0.21417 (rank : 180)	NC score	0.032339 (rank : 318)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

NACAM_MOUSE
θ value	0.21417 (rank : 181)	NC score	0.070856 (rank : 211)
Query Neighborhood Hits	453	Target Neighborhood Hits	1866	Shared Neighborhood Hits	164
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PTN4_HUMAN
θ value	0.21417 (rank : 182)	NC score	0.127382 (rank : 189)
Query Neighborhood Hits	453	Target Neighborhood Hits	303	Shared Neighborhood Hits	123
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SFR15_HUMAN
θ value	0.21417 (rank : 183)	NC score	0.048130 (rank : 267)
Query Neighborhood Hits	453	Target Neighborhood Hits	368	Shared Neighborhood Hits	53
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SRRM1_HUMAN
θ value	0.21417 (rank : 184)	NC score	0.098461 (rank : 198)
Query Neighborhood Hits	453	Target Neighborhood Hits	690	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SVIL_HUMAN
θ value	0.21417 (rank : 185)	NC score	0.045357 (rank : 273)
Query Neighborhood Hits	453	Target Neighborhood Hits	232	Shared Neighborhood Hits	42
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

BLNK_MOUSE
θ value	0.279714 (rank : 186)	NC score	0.052646 (rank : 253)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CENPT_MOUSE
θ value	0.279714 (rank : 187)	NC score	0.035596 (rank : 309)
Query Neighborhood Hits	453	Target Neighborhood Hits	115	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9	Gene names	Cenpt
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T).

RIMS2_HUMAN
θ value	0.279714 (rank : 188)	NC score	0.166216 (rank : 175)
Query Neighborhood Hits	453	Target Neighborhood Hits	342	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	0.279714 (rank : 189)	NC score	0.166738 (rank : 174)
Query Neighborhood Hits	453	Target Neighborhood Hits	376	Shared Neighborhood Hits	110
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

CAC1G_HUMAN
θ value	0.365318 (rank : 190)	NC score	0.018911 (rank : 376)
Query Neighborhood Hits	453	Target Neighborhood Hits	587	Shared Neighborhood Hits	65
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

DGKK_HUMAN
θ value	0.365318 (rank : 191)	NC score	0.030707 (rank : 327)
Query Neighborhood Hits	453	Target Neighborhood Hits	378	Shared Neighborhood Hits	53
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

EPN1_HUMAN
θ value	0.365318 (rank : 192)	NC score	0.025043 (rank : 356)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

KLF5_MOUSE
θ value	0.365318 (rank : 193)	NC score	0.001024 (rank : 488)
Query Neighborhood Hits	453	Target Neighborhood Hits	726	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z0Z7, Q9JMI2	Gene names	Klf5, Bteb2, Iklf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2).

NFIB_HUMAN
θ value	0.365318 (rank : 194)	NC score	0.039732 (rank : 289)
Query Neighborhood Hits	453	Target Neighborhood Hits	66	Shared Neighborhood Hits	17
SwissProt Accessions	O00712, O00166, Q12858, Q96J45	Gene names	NFIB
Domain Architecture
Description	Nuclear factor 1 B-type (Nuclear factor 1/B) (NF1-B) (NFI-B) (NF-I/B) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

PDZD3_MOUSE
θ value	0.365318 (rank : 195)	NC score	0.396023 (rank : 90)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	150
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PICK1_HUMAN
θ value	0.365318 (rank : 196)	NC score	0.297335 (rank : 117)
Query Neighborhood Hits	453	Target Neighborhood Hits	132	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	0.365318 (rank : 197)	NC score	0.299453 (rank : 116)
Query Neighborhood Hits	453	Target Neighborhood Hits	131	Shared Neighborhood Hits	113
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PRRT3_HUMAN
θ value	0.365318 (rank : 198)	NC score	0.045097 (rank : 276)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	113
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SH3K1_MOUSE
θ value	0.365318 (rank : 199)	NC score	0.031344 (rank : 323)
Query Neighborhood Hits	453	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

EFHB_MOUSE
θ value	0.47712 (rank : 200)	NC score	0.037159 (rank : 299)
Query Neighborhood Hits	453	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CDU5	Gene names	Efhb
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

EVI2B_HUMAN
θ value	0.47712 (rank : 201)	NC score	0.036563 (rank : 301)
Query Neighborhood Hits	453	Target Neighborhood Hits	135	Shared Neighborhood Hits	24
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

MAST2_MOUSE
θ value	0.47712 (rank : 202)	NC score	0.041884 (rank : 282)
Query Neighborhood Hits	453	Target Neighborhood Hits	1110	Shared Neighborhood Hits	146
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

OGFR_MOUSE
θ value	0.47712 (rank : 203)	NC score	0.046438 (rank : 271)
Query Neighborhood Hits	453	Target Neighborhood Hits	584	Shared Neighborhood Hits	61
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PDLI3_MOUSE
θ value	0.47712 (rank : 204)	NC score	0.168407 (rank : 173)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	98
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PTPRN_MOUSE
θ value	0.47712 (rank : 205)	NC score	0.027105 (rank : 347)
Query Neighborhood Hits	453	Target Neighborhood Hits	240	Shared Neighborhood Hits	22
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

ASPP1_MOUSE
θ value	0.62314 (rank : 206)	NC score	0.038637 (rank : 293)
Query Neighborhood Hits	453	Target Neighborhood Hits	1244	Shared Neighborhood Hits	104
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DCC_MOUSE
θ value	0.62314 (rank : 207)	NC score	0.016547 (rank : 390)
Query Neighborhood Hits	453	Target Neighborhood Hits	896	Shared Neighborhood Hits	68
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DPYL5_HUMAN
θ value	0.62314 (rank : 208)	NC score	0.009345 (rank : 440)
Query Neighborhood Hits	453	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BPU6, Q8TCL6, Q9NQC4, Q9NRY9	Gene names	DPYSL5, CRMP5, ULIP6
Domain Architecture
Description	Dihydropyrimidinase-related protein 5 (DRP-5) (ULIP6 protein) (Collapsin response mediator protein 5) (CRMP-5) (CRMP3-associated molecule) (CRAM).

LSR_MOUSE
θ value	0.62314 (rank : 209)	NC score	0.028258 (rank : 340)
Query Neighborhood Hits	453	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q99KG5, Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816	Gene names	Lsr, Lisch7
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor precursor (Liver-specific bHLH-Zip transcription factor) (Lipolysis-stimulated receptor) (Liver- specific gene on mouse chromosome 7 protein).

PDLI5_HUMAN
θ value	0.62314 (rank : 210)	NC score	0.142209 (rank : 184)
Query Neighborhood Hits	453	Target Neighborhood Hits	322	Shared Neighborhood Hits	117
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	0.62314 (rank : 211)	NC score	0.135720 (rank : 186)
Query Neighborhood Hits	453	Target Neighborhood Hits	287	Shared Neighborhood Hits	113
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PKHA2_HUMAN
θ value	0.62314 (rank : 212)	NC score	0.026764 (rank : 349)
Query Neighborhood Hits	453	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

STXB4_HUMAN
θ value	0.62314 (rank : 213)	NC score	0.277284 (rank : 123)
Query Neighborhood Hits	453	Target Neighborhood Hits	616	Shared Neighborhood Hits	111
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

ANK2_HUMAN
θ value	0.813845 (rank : 214)	NC score	0.038531 (rank : 294)
Query Neighborhood Hits	453	Target Neighborhood Hits	1615	Shared Neighborhood Hits	135
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

FIP1_HUMAN
θ value	0.813845 (rank : 215)	NC score	0.030767 (rank : 326)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

GNAS1_MOUSE
θ value	0.813845 (rank : 216)	NC score	0.016991 (rank : 386)
Query Neighborhood Hits	453	Target Neighborhood Hits	651	Shared Neighborhood Hits	82
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

MAP1A_HUMAN
θ value	0.813845 (rank : 217)	NC score	0.045292 (rank : 275)
Query Neighborhood Hits	453	Target Neighborhood Hits	1626	Shared Neighborhood Hits	114
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MUCDL_MOUSE
θ value	0.813845 (rank : 218)	NC score	0.030547 (rank : 328)
Query Neighborhood Hits	453	Target Neighborhood Hits	461	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

PRDM2_HUMAN
θ value	0.813845 (rank : 219)	NC score	0.008526 (rank : 448)
Query Neighborhood Hits	453	Target Neighborhood Hits	1135	Shared Neighborhood Hits	75
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

RPGF1_HUMAN
θ value	0.813845 (rank : 220)	NC score	0.028513 (rank : 337)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	25
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SCN4A_HUMAN
θ value	0.813845 (rank : 221)	NC score	0.006585 (rank : 462)
Query Neighborhood Hits	453	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SDCB2_HUMAN
θ value	0.813845 (rank : 222)	NC score	0.281065 (rank : 122)
Query Neighborhood Hits	453	Target Neighborhood Hits	121	Shared Neighborhood Hits	114
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TIAM1_HUMAN
θ value	0.813845 (rank : 223)	NC score	0.079851 (rank : 204)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	0.813845 (rank : 224)	NC score	0.062122 (rank : 229)
Query Neighborhood Hits	453	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

US6NL_HUMAN
θ value	0.813845 (rank : 225)	NC score	0.028964 (rank : 336)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	41
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

AKAP2_MOUSE
θ value	1.06291 (rank : 226)	NC score	0.048001 (rank : 269)
Query Neighborhood Hits	453	Target Neighborhood Hits	385	Shared Neighborhood Hits	35
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

CMTA1_HUMAN
θ value	1.06291 (rank : 227)	NC score	0.025370 (rank : 354)
Query Neighborhood Hits	453	Target Neighborhood Hits	217	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

HRSL5_HUMAN
θ value	1.06291 (rank : 228)	NC score	0.016125 (rank : 391)
Query Neighborhood Hits	453	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q96KN8	Gene names	HRASLS5, HRLP5
Domain Architecture
Description	HRAS-like suppressor 5 (H-rev107-like protein 5).

HTRA3_MOUSE
θ value	1.06291 (rank : 229)	NC score	0.104663 (rank : 196)
Query Neighborhood Hits	453	Target Neighborhood Hits	156	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

MAGE1_HUMAN
θ value	1.06291 (rank : 230)	NC score	0.032599 (rank : 316)
Query Neighborhood Hits	453	Target Neighborhood Hits	1389	Shared Neighborhood Hits	131
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAST2_HUMAN
θ value	1.06291 (rank : 231)	NC score	0.043236 (rank : 280)
Query Neighborhood Hits	453	Target Neighborhood Hits	1189	Shared Neighborhood Hits	156
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

RBBP6_HUMAN
θ value	1.06291 (rank : 232)	NC score	0.056286 (rank : 242)
Query Neighborhood Hits	453	Target Neighborhood Hits	1135	Shared Neighborhood Hits	94
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SOX30_MOUSE
θ value	1.06291 (rank : 233)	NC score	0.016908 (rank : 387)
Query Neighborhood Hits	453	Target Neighborhood Hits	374	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

SYNP2_HUMAN
θ value	1.06291 (rank : 234)	NC score	0.170449 (rank : 171)
Query Neighborhood Hits	453	Target Neighborhood Hits	323	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

ZEP2_MOUSE
θ value	1.06291 (rank : 235)	NC score	0.005760 (rank : 466)
Query Neighborhood Hits	453	Target Neighborhood Hits	964	Shared Neighborhood Hits	64
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

BAG3_MOUSE
θ value	1.38821 (rank : 236)	NC score	0.055489 (rank : 244)
Query Neighborhood Hits	453	Target Neighborhood Hits	513	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CS019_MOUSE
θ value	1.38821 (rank : 237)	NC score	0.029557 (rank : 334)
Query Neighborhood Hits	453	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D7E4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf25 homolog.

FBX46_MOUSE
θ value	1.38821 (rank : 238)	NC score	0.016695 (rank : 389)
Query Neighborhood Hits	453	Target Neighborhood Hits	139	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

GAB1_HUMAN
θ value	1.38821 (rank : 239)	NC score	0.029940 (rank : 333)
Query Neighborhood Hits	453	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
θ value	1.38821 (rank : 240)	NC score	0.027763 (rank : 343)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GNDS_HUMAN
θ value	1.38821 (rank : 241)	NC score	0.037009 (rank : 300)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	37
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

HNRL1_MOUSE
θ value	1.38821 (rank : 242)	NC score	0.031855 (rank : 321)
Query Neighborhood Hits	453	Target Neighborhood Hits	200	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

HTRA1_HUMAN
θ value	1.38821 (rank : 243)	NC score	0.063266 (rank : 223)
Query Neighborhood Hits	453	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

PDLI4_MOUSE
θ value	1.38821 (rank : 244)	NC score	0.185527 (rank : 163)
Query Neighborhood Hits	453	Target Neighborhood Hits	233	Shared Neighborhood Hits	105
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

RPB1_MOUSE
θ value	1.38821 (rank : 245)	NC score	0.053823 (rank : 247)
Query Neighborhood Hits	453	Target Neighborhood Hits	363	Shared Neighborhood Hits	63
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SRRM1_MOUSE
θ value	1.38821 (rank : 246)	NC score	0.089153 (rank : 202)
Query Neighborhood Hits	453	Target Neighborhood Hits	966	Shared Neighborhood Hits	126
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

WWP2_HUMAN
θ value	1.38821 (rank : 247)	NC score	0.027176 (rank : 346)
Query Neighborhood Hits	453	Target Neighborhood Hits	177	Shared Neighborhood Hits	28
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

AFAD_HUMAN
θ value	1.81305 (rank : 248)	NC score	0.343975 (rank : 106)
Query Neighborhood Hits	453	Target Neighborhood Hits	689	Shared Neighborhood Hits	169
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

BLNK_HUMAN
θ value	1.81305 (rank : 249)	NC score	0.034029 (rank : 313)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

DYR1B_MOUSE
θ value	1.81305 (rank : 250)	NC score	0.004816 (rank : 476)
Query Neighborhood Hits	453	Target Neighborhood Hits	799	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

EFS_MOUSE
θ value	1.81305 (rank : 251)	NC score	0.039323 (rank : 290)
Query Neighborhood Hits	453	Target Neighborhood Hits	389	Shared Neighborhood Hits	47
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

GAB2_MOUSE
θ value	1.81305 (rank : 252)	NC score	0.026866 (rank : 348)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

HRX_HUMAN
θ value	1.81305 (rank : 253)	NC score	0.027235 (rank : 345)
Query Neighborhood Hits	453	Target Neighborhood Hits	825	Shared Neighborhood Hits	89
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

HTRA1_MOUSE
θ value	1.81305 (rank : 254)	NC score	0.061851 (rank : 230)
Query Neighborhood Hits	453	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HXD4_HUMAN
θ value	1.81305 (rank : 255)	NC score	-0.000828 (rank : 493)
Query Neighborhood Hits	453	Target Neighborhood Hits	337	Shared Neighborhood Hits	8
SwissProt Accessions	P09016, Q96AU0	Gene names	HOXD4, HOX4B
Domain Architecture
Description	Homeobox protein Hox-D4 (Hox-4B) (Hox-5.1) (HHO.C13).

IWS1_MOUSE
θ value	1.81305 (rank : 256)	NC score	0.052674 (rank : 252)
Query Neighborhood Hits	453	Target Neighborhood Hits	1258	Shared Neighborhood Hits	105
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MAST1_HUMAN
θ value	1.81305 (rank : 257)	NC score	0.036143 (rank : 304)
Query Neighborhood Hits	453	Target Neighborhood Hits	1146	Shared Neighborhood Hits	141
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MPP4_HUMAN
θ value	1.81305 (rank : 258)	NC score	0.411240 (rank : 83)
Query Neighborhood Hits	453	Target Neighborhood Hits	205	Shared Neighborhood Hits	131
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NHRF2_MOUSE
θ value	1.81305 (rank : 259)	NC score	0.409869 (rank : 85)
Query Neighborhood Hits	453	Target Neighborhood Hits	194	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NOS1_HUMAN
θ value	1.81305 (rank : 260)	NC score	0.224107 (rank : 147)
Query Neighborhood Hits	453	Target Neighborhood Hits	218	Shared Neighborhood Hits	140
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PCLO_HUMAN
θ value	1.81305 (rank : 261)	NC score	0.057325 (rank : 239)
Query Neighborhood Hits	453	Target Neighborhood Hits	2046	Shared Neighborhood Hits	185
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PDZD8_HUMAN
θ value	1.81305 (rank : 262)	NC score	0.117052 (rank : 192)
Query Neighborhood Hits	453	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PSCBP_HUMAN
θ value	1.81305 (rank : 263)	NC score	0.213931 (rank : 152)
Query Neighborhood Hits	453	Target Neighborhood Hits	123	Shared Neighborhood Hits	108
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

RC3H1_HUMAN
θ value	1.81305 (rank : 264)	NC score	0.027854 (rank : 342)
Query Neighborhood Hits	453	Target Neighborhood Hits	433	Shared Neighborhood Hits	46
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RHPN1_HUMAN
θ value	1.81305 (rank : 265)	NC score	0.229145 (rank : 144)
Query Neighborhood Hits	453	Target Neighborhood Hits	158	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RTN1_HUMAN
θ value	1.81305 (rank : 266)	NC score	0.019686 (rank : 373)
Query Neighborhood Hits	453	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

SPEG_HUMAN
θ value	1.81305 (rank : 267)	NC score	0.013489 (rank : 405)
Query Neighborhood Hits	453	Target Neighborhood Hits	1762	Shared Neighborhood Hits	129
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STAT6_MOUSE
θ value	1.81305 (rank : 268)	NC score	0.014304 (rank : 398)
Query Neighborhood Hits	453	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	P52633	Gene names	Stat6
Domain Architecture
Description	Signal transducer and transcription activator 6.

YLPM1_HUMAN
θ value	1.81305 (rank : 269)	NC score	0.057601 (rank : 238)
Query Neighborhood Hits	453	Target Neighborhood Hits	670	Shared Neighborhood Hits	100
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

BCL9_MOUSE
θ value	2.36792 (rank : 270)	NC score	0.042197 (rank : 281)
Query Neighborhood Hits	453	Target Neighborhood Hits	770	Shared Neighborhood Hits	99
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CO2A1_HUMAN
θ value	2.36792 (rank : 271)	NC score	0.009625 (rank : 438)
Query Neighborhood Hits	453	Target Neighborhood Hits	486	Shared Neighborhood Hits	44
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CS016_HUMAN
θ value	2.36792 (rank : 272)	NC score	0.050969 (rank : 259)
Query Neighborhood Hits	453	Target Neighborhood Hits	310	Shared Neighborhood Hits	55
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DYR1B_HUMAN
θ value	2.36792 (rank : 273)	NC score	0.004609 (rank : 477)
Query Neighborhood Hits	453	Target Neighborhood Hits	831	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

GLI2_HUMAN
θ value	2.36792 (rank : 274)	NC score	-0.000818 (rank : 492)
Query Neighborhood Hits	453	Target Neighborhood Hits	971	Shared Neighborhood Hits	51
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

GP152_MOUSE
θ value	2.36792 (rank : 275)	NC score	0.008630 (rank : 446)
Query Neighborhood Hits	453	Target Neighborhood Hits	607	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

K0100_MOUSE
θ value	2.36792 (rank : 276)	NC score	0.011456 (rank : 419)
Query Neighborhood Hits	453	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SYL3, Q3UE65, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8	Gene names	Kiaa0100
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor.

KMHN1_MOUSE
θ value	2.36792 (rank : 277)	NC score	0.015218 (rank : 393)
Query Neighborhood Hits	453	Target Neighborhood Hits	949	Shared Neighborhood Hits	36
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

LDB3_HUMAN
θ value	2.36792 (rank : 278)	NC score	0.143041 (rank : 183)
Query Neighborhood Hits	453	Target Neighborhood Hits	497	Shared Neighborhood Hits	140
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	2.36792 (rank : 279)	NC score	0.143991 (rank : 182)
Query Neighborhood Hits	453	Target Neighborhood Hits	510	Shared Neighborhood Hits	148
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LRC8E_MOUSE
θ value	2.36792 (rank : 280)	NC score	0.032676 (rank : 315)
Query Neighborhood Hits	453	Target Neighborhood Hits	256	Shared Neighborhood Hits	12
SwissProt Accessions	Q66JT1	Gene names	Lrrc8e
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

PHC2_MOUSE
θ value	2.36792 (rank : 281)	NC score	0.017700 (rank : 382)
Query Neighborhood Hits	453	Target Neighborhood Hits	156	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

PO6F2_HUMAN
θ value	2.36792 (rank : 282)	NC score	0.013061 (rank : 407)
Query Neighborhood Hits	453	Target Neighborhood Hits	618	Shared Neighborhood Hits	57
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

PRR8_HUMAN
θ value	2.36792 (rank : 283)	NC score	0.041779 (rank : 283)
Query Neighborhood Hits	453	Target Neighborhood Hits	217	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RBBP6_MOUSE
θ value	2.36792 (rank : 284)	NC score	0.051585 (rank : 257)
Query Neighborhood Hits	453	Target Neighborhood Hits	1014	Shared Neighborhood Hits	90
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RGS3_MOUSE
θ value	2.36792 (rank : 285)	NC score	0.075381 (rank : 205)
Query Neighborhood Hits	453	Target Neighborhood Hits	1621	Shared Neighborhood Hits	199
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RPB1_HUMAN
θ value	2.36792 (rank : 286)	NC score	0.051614 (rank : 256)
Query Neighborhood Hits	453	Target Neighborhood Hits	362	Shared Neighborhood Hits	63
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SC24A_MOUSE
θ value	2.36792 (rank : 287)	NC score	0.022866 (rank : 362)
Query Neighborhood Hits	453	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SNUT3_HUMAN
θ value	2.36792 (rank : 288)	NC score	0.041192 (rank : 284)
Query Neighborhood Hits	453	Target Neighborhood Hits	52	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WVK2, Q15410	Gene names
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 3 (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (Nucleic acid-binding protein RY-1).

U2AF2_HUMAN
θ value	2.36792 (rank : 289)	NC score	0.010798 (rank : 430)
Query Neighborhood Hits	453	Target Neighborhood Hits	192	Shared Neighborhood Hits	8
SwissProt Accessions	P26368	Gene names	U2AF2, U2AF65
Domain Architecture
Description	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2 snRNP auxiliary factor large subunit) (hU2AF(65)).

U2AF2_MOUSE
θ value	2.36792 (rank : 290)	NC score	0.010752 (rank : 431)
Query Neighborhood Hits	453	Target Neighborhood Hits	192	Shared Neighborhood Hits	8
SwissProt Accessions	P26369	Gene names	U2af2, U2af65
Domain Architecture
Description	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2 snRNP auxiliary factor large subunit).

ALEX_HUMAN
θ value	3.0926 (rank : 291)	NC score	0.040551 (rank : 288)
Query Neighborhood Hits	453	Target Neighborhood Hits	361	Shared Neighborhood Hits	72
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ARHGA_HUMAN
θ value	3.0926 (rank : 292)	NC score	0.014328 (rank : 397)
Query Neighborhood Hits	453	Target Neighborhood Hits	187	Shared Neighborhood Hits	12
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BCL6_HUMAN
θ value	3.0926 (rank : 293)	NC score	-0.003530 (rank : 500)
Query Neighborhood Hits	453	Target Neighborhood Hits	922	Shared Neighborhood Hits	37
SwissProt Accessions	P41182	Gene names	BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Domain Architecture
Description	B-cell lymphoma 6 protein (BCL-6) (Zinc finger protein 51) (LAZ-3 protein) (BCL-5) (Zinc finger and BTB domain-containing protein 27).

DEN2C_MOUSE
θ value	3.0926 (rank : 294)	NC score	0.006481 (rank : 463)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DSC3_HUMAN
θ value	3.0926 (rank : 295)	NC score	-0.000718 (rank : 491)
Query Neighborhood Hits	453	Target Neighborhood Hits	150	Shared Neighborhood Hits	5
SwissProt Accessions	Q14574, Q14200, Q9HAZ9	Gene names	DSC3, DSC4
Domain Architecture
Description	Desmocollin-3 precursor (Desmocollin-4) (HT-CP).

GAS1_HUMAN
θ value	3.0926 (rank : 296)	NC score	0.026388 (rank : 350)
Query Neighborhood Hits	453	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	P54826	Gene names	GAS1
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 1 precursor (GAS-1).

GIDRP_MOUSE
θ value	3.0926 (rank : 297)	NC score	0.025567 (rank : 352)
Query Neighborhood Hits	453	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

K1210_HUMAN
θ value	3.0926 (rank : 298)	NC score	0.035647 (rank : 308)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

LMO7_HUMAN
θ value	3.0926 (rank : 299)	NC score	0.120077 (rank : 191)
Query Neighborhood Hits	453	Target Neighborhood Hits	507	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LSR_HUMAN
θ value	3.0926 (rank : 300)	NC score	0.025281 (rank : 355)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

LYSM2_HUMAN
θ value	3.0926 (rank : 301)	NC score	0.014193 (rank : 400)
Query Neighborhood Hits	453	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IV50, Q5CZ88, Q8WTV3	Gene names	LYSMD2
Domain Architecture	No domain graphic available
Description	LysM and putative peptidoglycan-binding domain-containing protein 2.

MAGC1_HUMAN
θ value	3.0926 (rank : 302)	NC score	0.022415 (rank : 364)
Query Neighborhood Hits	453	Target Neighborhood Hits	431	Shared Neighborhood Hits	62
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MAST1_MOUSE
θ value	3.0926 (rank : 303)	NC score	0.037240 (rank : 298)
Query Neighborhood Hits	453	Target Neighborhood Hits	1123	Shared Neighborhood Hits	139
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MGA_HUMAN
θ value	3.0926 (rank : 304)	NC score	0.007524 (rank : 458)
Query Neighborhood Hits	453	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O43451	Gene names	MGAM, MGA, MGAML
Domain Architecture
Description	Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha- glucosidase)].

NCOA6_HUMAN
θ value	3.0926 (rank : 305)	NC score	0.048716 (rank : 264)
Query Neighborhood Hits	453	Target Neighborhood Hits	1202	Shared Neighborhood Hits	140
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NRBF2_HUMAN
θ value	3.0926 (rank : 306)	NC score	0.013823 (rank : 401)
Query Neighborhood Hits	453	Target Neighborhood Hits	122	Shared Neighborhood Hits	8
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

PDLI3_HUMAN
θ value	3.0926 (rank : 307)	NC score	0.181942 (rank : 165)
Query Neighborhood Hits	453	Target Neighborhood Hits	199	Shared Neighborhood Hits	102
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PRDM8_HUMAN
θ value	3.0926 (rank : 308)	NC score	0.009111 (rank : 442)
Query Neighborhood Hits	453	Target Neighborhood Hits	591	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQV8, Q6IQ36	Gene names	PRDM8, PFM5
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 8 (PR domain-containing protein 8).

RGS3_HUMAN
θ value	3.0926 (rank : 309)	NC score	0.066167 (rank : 219)
Query Neighborhood Hits	453	Target Neighborhood Hits	1375	Shared Neighborhood Hits	161
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SFRS4_MOUSE
θ value	3.0926 (rank : 310)	NC score	0.020030 (rank : 372)
Query Neighborhood Hits	453	Target Neighborhood Hits	406	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

SMCA5_MOUSE
θ value	3.0926 (rank : 311)	NC score	0.004863 (rank : 474)
Query Neighborhood Hits	453	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q91ZW3, Q8C791, Q8CA22, Q8VDG1, Q925M9	Gene names	Smarca5, Snf2h
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h).

TMBI1_MOUSE
θ value	3.0926 (rank : 312)	NC score	0.011058 (rank : 424)
Query Neighborhood Hits	453	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJZ3, Q8CH91, Q99KB6	Gene names	Tmbim1, Recs1
Domain Architecture
Description	Transmembrane BAX inhibitor motif-containing protein 1 (RECS1 protein) (Responsive to centrifugal force and shear stress gene 1 protein).

TRI47_HUMAN
θ value	3.0926 (rank : 313)	NC score	0.020165 (rank : 371)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	17
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

ZBT46_HUMAN
θ value	3.0926 (rank : 314)	NC score	-0.003528 (rank : 499)
Query Neighborhood Hits	453	Target Neighborhood Hits	813	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UZ6, Q5JWJ3, Q9BQK3, Q9H3Z8, Q9H3Z9	Gene names	ZBTB46, BTBD4, ZNF340
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 46 (BTB/POZ domain- containing protein 4) (Zinc finger protein 340).

ZGPAT_HUMAN
θ value	3.0926 (rank : 315)	NC score	0.011799 (rank : 414)
Query Neighborhood Hits	453	Target Neighborhood Hits	97	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5A5, Q5JWI9, Q8NC55, Q96JI0, Q96JU4, Q9H401	Gene names	ZGPAT, KIAA1847, ZC3H9, ZC3HDC9
Domain Architecture
Description	Zinc finger CCCH-type with G patch domain protein (Zinc finger CCCH domain-containing protein 9).

ACINU_HUMAN
θ value	4.03905 (rank : 316)	NC score	0.034063 (rank : 312)
Query Neighborhood Hits	453	Target Neighborhood Hits	828	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BANK1_MOUSE
θ value	4.03905 (rank : 317)	NC score	0.015073 (rank : 395)
Query Neighborhood Hits	453	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	Q80VH0, Q3U178, Q8BRV6, Q8BRY8	Gene names	Bank1
Domain Architecture	No domain graphic available
Description	B-cell scaffold protein with ankyrin repeats (Protein AVIEF).

BAT2_MOUSE
θ value	4.03905 (rank : 318)	NC score	0.044847 (rank : 277)
Query Neighborhood Hits	453	Target Neighborhood Hits	947	Shared Neighborhood Hits	127
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CDN1C_HUMAN
θ value	4.03905 (rank : 319)	NC score	0.025918 (rank : 351)
Query Neighborhood Hits	453	Target Neighborhood Hits	168	Shared Neighborhood Hits	30
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CHD6_HUMAN
θ value	4.03905 (rank : 320)	NC score	0.009392 (rank : 439)
Query Neighborhood Hits	453	Target Neighborhood Hits	342	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

DDX46_MOUSE
θ value	4.03905 (rank : 321)	NC score	0.005358 (rank : 469)
Query Neighborhood Hits	453	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

EHMT2_MOUSE
θ value	4.03905 (rank : 322)	NC score	0.011780 (rank : 415)
Query Neighborhood Hits	453	Target Neighborhood Hits	750	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ELOA3_HUMAN
θ value	4.03905 (rank : 323)	NC score	0.015113 (rank : 394)
Query Neighborhood Hits	453	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

ETV3_HUMAN
θ value	4.03905 (rank : 324)	NC score	0.013446 (rank : 406)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

GAK2_HUMAN
θ value	4.03905 (rank : 325)	NC score	0.013033 (rank : 408)
Query Neighborhood Hits	453	Target Neighborhood Hits	406	Shared Neighborhood Hits	45
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IF39_MOUSE
θ value	4.03905 (rank : 326)	NC score	0.018052 (rank : 380)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	25
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

IF4G1_MOUSE
θ value	4.03905 (rank : 327)	NC score	0.021110 (rank : 368)
Query Neighborhood Hits	453	Target Neighborhood Hits	534	Shared Neighborhood Hits	65
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

MAST3_HUMAN
θ value	4.03905 (rank : 328)	NC score	0.038690 (rank : 292)
Query Neighborhood Hits	453	Target Neighborhood Hits	1128	Shared Neighborhood Hits	160
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MLL3_HUMAN
θ value	4.03905 (rank : 329)	NC score	0.035951 (rank : 307)
Query Neighborhood Hits	453	Target Neighborhood Hits	1644	Shared Neighborhood Hits	137
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NBR1_HUMAN
θ value	4.03905 (rank : 330)	NC score	0.024658 (rank : 358)
Query Neighborhood Hits	453	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

NCOA6_MOUSE
θ value	4.03905 (rank : 331)	NC score	0.038166 (rank : 296)
Query Neighborhood Hits	453	Target Neighborhood Hits	1076	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NIPBL_HUMAN
θ value	4.03905 (rank : 332)	NC score	0.041161 (rank : 285)
Query Neighborhood Hits	453	Target Neighborhood Hits	1311	Shared Neighborhood Hits	106
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NOS3_MOUSE
θ value	4.03905 (rank : 333)	NC score	0.012276 (rank : 412)
Query Neighborhood Hits	453	Target Neighborhood Hits	63	Shared Neighborhood Hits	11
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

PAR6B_HUMAN
θ value	4.03905 (rank : 334)	NC score	0.261481 (rank : 128)
Query Neighborhood Hits	453	Target Neighborhood Hits	126	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	4.03905 (rank : 335)	NC score	0.263066 (rank : 127)
Query Neighborhood Hits	453	Target Neighborhood Hits	128	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

RGS12_HUMAN
θ value	4.03905 (rank : 336)	NC score	0.204930 (rank : 157)
Query Neighborhood Hits	453	Target Neighborhood Hits	333	Shared Neighborhood Hits	145
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SNIP_HUMAN
θ value	4.03905 (rank : 337)	NC score	0.018988 (rank : 374)
Query Neighborhood Hits	453	Target Neighborhood Hits	313	Shared Neighborhood Hits	30
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

SSXT_HUMAN
θ value	4.03905 (rank : 338)	NC score	0.022500 (rank : 363)
Query Neighborhood Hits	453	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q15532, Q16404, Q9BXC6	Gene names	SS18, SSXT, SYT
Domain Architecture
Description	SSXT protein (Synovial sarcoma, translocated to X chromosome) (SYT protein).

TAB3_MOUSE
θ value	4.03905 (rank : 339)	NC score	0.024041 (rank : 360)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	53
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

TERF2_MOUSE
θ value	4.03905 (rank : 340)	NC score	0.014199 (rank : 399)
Query Neighborhood Hits	453	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	O35144	Gene names	Terf2, Trf2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

TLE1_HUMAN
θ value	4.03905 (rank : 341)	NC score	0.003054 (rank : 483)
Query Neighborhood Hits	453	Target Neighborhood Hits	485	Shared Neighborhood Hits	28
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TMM51_MOUSE
θ value	4.03905 (rank : 342)	NC score	0.052637 (rank : 254)
Query Neighborhood Hits	453	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q99LG1, Q3TPZ3	Gene names	Tmem51
Domain Architecture	No domain graphic available
Description	Transmembrane protein 51.

TUB_HUMAN
θ value	4.03905 (rank : 343)	NC score	0.007813 (rank : 453)
Query Neighborhood Hits	453	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	P50607, O00293	Gene names	TUB
Domain Architecture
Description	Tubby protein homolog.

ZC313_HUMAN
θ value	4.03905 (rank : 344)	NC score	0.028487 (rank : 338)
Query Neighborhood Hits	453	Target Neighborhood Hits	772	Shared Neighborhood Hits	59
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ACINU_MOUSE
θ value	5.27518 (rank : 345)	NC score	0.031146 (rank : 325)
Query Neighborhood Hits	453	Target Neighborhood Hits	712	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

APBA1_HUMAN
θ value	5.27518 (rank : 346)	NC score	0.309399 (rank : 111)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	152
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	5.27518 (rank : 347)	NC score	0.282784 (rank : 119)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	136
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	5.27518 (rank : 348)	NC score	0.282636 (rank : 120)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	136
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

BCL9_HUMAN
θ value	5.27518 (rank : 349)	NC score	0.048093 (rank : 268)
Query Neighborhood Hits	453	Target Neighborhood Hits	1008	Shared Neighborhood Hits	130
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BTBD7_MOUSE
θ value	5.27518 (rank : 350)	NC score	0.008348 (rank : 449)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

CA106_HUMAN
θ value	5.27518 (rank : 351)	NC score	0.013646 (rank : 402)
Query Neighborhood Hits	453	Target Neighborhood Hits	124	Shared Neighborhood Hits	17
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CD2AP_HUMAN
θ value	5.27518 (rank : 352)	NC score	0.023881 (rank : 361)
Query Neighborhood Hits	453	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CO1A1_HUMAN
θ value	5.27518 (rank : 353)	NC score	0.010248 (rank : 434)
Query Neighborhood Hits	453	Target Neighborhood Hits	475	Shared Neighborhood Hits	42
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO4A2_MOUSE
θ value	5.27518 (rank : 354)	NC score	0.004818 (rank : 475)
Query Neighborhood Hits	453	Target Neighborhood Hits	492	Shared Neighborhood Hits	41
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

DGCR8_MOUSE
θ value	5.27518 (rank : 355)	NC score	0.010451 (rank : 433)
Query Neighborhood Hits	453	Target Neighborhood Hits	70	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

FA47B_HUMAN
θ value	5.27518 (rank : 356)	NC score	0.031577 (rank : 322)
Query Neighborhood Hits	453	Target Neighborhood Hits	431	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FAK1_MOUSE
θ value	5.27518 (rank : 357)	NC score	-0.002147 (rank : 498)
Query Neighborhood Hits	453	Target Neighborhood Hits	850	Shared Neighborhood Hits	25
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FBLN2_MOUSE
θ value	5.27518 (rank : 358)	NC score	0.001742 (rank : 484)
Query Neighborhood Hits	453	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FRK_HUMAN
θ value	5.27518 (rank : 359)	NC score	0.010981 (rank : 427)
Query Neighborhood Hits	453	Target Neighborhood Hits	1058	Shared Neighborhood Hits	57
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FUSIP_HUMAN
θ value	5.27518 (rank : 360)	NC score	0.006718 (rank : 460)
Query Neighborhood Hits	453	Target Neighborhood Hits	230	Shared Neighborhood Hits	15
SwissProt Accessions	O75494, O60572, Q96G09, Q96P17	Gene names	FUSIP1, TASR
Domain Architecture
Description	FUS-interacting serine-arginine-rich protein 1 (TLS-associated protein with Ser-Arg repeats) (TLS-associated protein with SR repeats) (TASR) (TLS-associated serine-arginine protein) (TLS-associated SR protein) (40 kDa SR-repressor protein) (SRrp40) (Splicing factor SRp38).

FUSIP_MOUSE
θ value	5.27518 (rank : 361)	NC score	0.006718 (rank : 461)
Query Neighborhood Hits	453	Target Neighborhood Hits	230	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0U0, O70307, O88468, Q3TGW7, Q8CFZ1, Q9R0T9	Gene names	Fusip1, Nssr
Domain Architecture
Description	FUS-interacting serine-arginine-rich protein 1 (TLS-associated protein with Ser-Arg repeats) (TLS-associated protein with SR repeats) (TASR) (TLS-associated serine-arginine protein) (TLS-associated SR protein) (Neural-specific SR protein) (Neural-salient serine/arginine-rich protein).

GAK12_HUMAN
θ value	5.27518 (rank : 362)	NC score	0.012121 (rank : 413)
Query Neighborhood Hits	453	Target Neighborhood Hits	374	Shared Neighborhood Hits	43
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GTSE1_MOUSE
θ value	5.27518 (rank : 363)	NC score	0.024374 (rank : 359)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

HIPK1_HUMAN
θ value	5.27518 (rank : 364)	NC score	0.005497 (rank : 467)
Query Neighborhood Hits	453	Target Neighborhood Hits	843	Shared Neighborhood Hits	31
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HKR3_HUMAN
θ value	5.27518 (rank : 365)	NC score	-0.005560 (rank : 503)
Query Neighborhood Hits	453	Target Neighborhood Hits	839	Shared Neighborhood Hits	25
SwissProt Accessions	P10074	Gene names	HKR3
Domain Architecture
Description	Krueppel-related zinc finger protein 3 (Protein HKR3).

HRBL_HUMAN
θ value	5.27518 (rank : 366)	NC score	0.010901 (rank : 428)
Query Neighborhood Hits	453	Target Neighborhood Hits	179	Shared Neighborhood Hits	21
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

ICB1_MOUSE
θ value	5.27518 (rank : 367)	NC score	0.017537 (rank : 383)
Query Neighborhood Hits	453	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q91YX0	Gene names	Icb1
Domain Architecture	No domain graphic available
Description	Induced by contact to basement membrane 1 protein homolog (ICB-1 protein).

MBD5_HUMAN
θ value	5.27518 (rank : 368)	NC score	0.017798 (rank : 381)
Query Neighborhood Hits	453	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

MKL1_MOUSE
θ value	5.27518 (rank : 369)	NC score	0.018339 (rank : 379)
Query Neighborhood Hits	453	Target Neighborhood Hits	667	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MORC4_HUMAN
θ value	5.27518 (rank : 370)	NC score	0.010151 (rank : 436)
Query Neighborhood Hits	453	Target Neighborhood Hits	244	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TE76, Q5JUK7, Q96MZ2, Q9HAI7	Gene names	MORC4, ZCWCC2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

NCOR1_HUMAN
θ value	5.27518 (rank : 371)	NC score	0.018979 (rank : 375)
Query Neighborhood Hits	453	Target Neighborhood Hits	577	Shared Neighborhood Hits	58
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

NCOR1_MOUSE
θ value	5.27518 (rank : 372)	NC score	0.031332 (rank : 324)
Query Neighborhood Hits	453	Target Neighborhood Hits	521	Shared Neighborhood Hits	72
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NFH_HUMAN
θ value	5.27518 (rank : 373)	NC score	0.030008 (rank : 332)
Query Neighborhood Hits	453	Target Neighborhood Hits	1242	Shared Neighborhood Hits	101
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NPBL_MOUSE
θ value	5.27518 (rank : 374)	NC score	0.044664 (rank : 278)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	94
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PER2_MOUSE
θ value	5.27518 (rank : 375)	NC score	0.011224 (rank : 422)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	26
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PTN3_HUMAN
θ value	5.27518 (rank : 376)	NC score	0.112764 (rank : 194)
Query Neighborhood Hits	453	Target Neighborhood Hits	258	Shared Neighborhood Hits	112
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

RBP56_HUMAN
θ value	5.27518 (rank : 377)	NC score	0.012577 (rank : 410)
Query Neighborhood Hits	453	Target Neighborhood Hits	157	Shared Neighborhood Hits	8
SwissProt Accessions	Q92804, Q92751	Gene names	TAF15, RBP56, TAF2N
Domain Architecture
Description	TATA-binding protein-associated factor 2N (RNA-binding protein 56) (TAFII68) (TAF(II)68).

SHAN1_HUMAN
θ value	5.27518 (rank : 378)	NC score	0.126097 (rank : 190)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	201
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SLIK5_MOUSE
θ value	5.27518 (rank : 379)	NC score	0.010209 (rank : 435)
Query Neighborhood Hits	453	Target Neighborhood Hits	301	Shared Neighborhood Hits	12
SwissProt Accessions	Q810B7, Q9CT21	Gene names	Slitrk5
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor.

SOCS6_MOUSE
θ value	5.27518 (rank : 380)	NC score	0.008545 (rank : 447)
Query Neighborhood Hits	453	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SSXT_MOUSE
θ value	5.27518 (rank : 381)	NC score	0.017217 (rank : 384)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	21
SwissProt Accessions	Q62280	Gene names	Ss18, Ssxt, Syt
Domain Architecture
Description	SSXT protein (SYT protein) (Synovial sarcoma-associated Ss18-alpha).

TARA_MOUSE
θ value	5.27518 (rank : 382)	NC score	0.038365 (rank : 295)
Query Neighborhood Hits	453	Target Neighborhood Hits	1133	Shared Neighborhood Hits	107
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TF2L1_HUMAN
θ value	5.27518 (rank : 383)	NC score	0.011054 (rank : 425)
Query Neighborhood Hits	453	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZI6, Q4ZG43	Gene names	TFCP2L1, CRTR1, LBP9
Domain Architecture	No domain graphic available
Description	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9).

TF2L1_MOUSE
θ value	5.27518 (rank : 384)	NC score	0.011652 (rank : 416)
Query Neighborhood Hits	453	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q3UNW5, Q99PF2	Gene names	Tcfcp2l1, Crtr1
Domain Architecture	No domain graphic available
Description	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1).

TP53B_MOUSE
θ value	5.27518 (rank : 385)	NC score	0.034333 (rank : 311)
Query Neighborhood Hits	453	Target Neighborhood Hits	644	Shared Neighborhood Hits	74
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

YBOX2_HUMAN
θ value	5.27518 (rank : 386)	NC score	0.009266 (rank : 441)
Query Neighborhood Hits	453	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2T7, Q8N4P0	Gene names	YBX2
Domain Architecture	No domain graphic available
Description	Y-box-binding protein 2 (Germ cell-specific Y-box-binding protein) (Contrin) (MSY2 homolog).

AATK_HUMAN
θ value	6.88961 (rank : 387)	NC score	-0.001374 (rank : 496)
Query Neighborhood Hits	453	Target Neighborhood Hits	1243	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AFF1_HUMAN
θ value	6.88961 (rank : 388)	NC score	0.039050 (rank : 291)
Query Neighborhood Hits	453	Target Neighborhood Hits	506	Shared Neighborhood Hits	74
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

AFF4_MOUSE
θ value	6.88961 (rank : 389)	NC score	0.028041 (rank : 341)
Query Neighborhood Hits	453	Target Neighborhood Hits	581	Shared Neighborhood Hits	70
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ARMX2_MOUSE
θ value	6.88961 (rank : 390)	NC score	0.014940 (rank : 396)
Query Neighborhood Hits	453	Target Neighborhood Hits	349	Shared Neighborhood Hits	40
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

BAG3_HUMAN
θ value	6.88961 (rank : 391)	NC score	0.050124 (rank : 263)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BCAR1_HUMAN
θ value	6.88961 (rank : 392)	NC score	0.031914 (rank : 320)
Query Neighborhood Hits	453	Target Neighborhood Hits	554	Shared Neighborhood Hits	73
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	6.88961 (rank : 393)	NC score	0.027616 (rank : 344)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	63
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CCAR1_HUMAN
θ value	6.88961 (rank : 394)	NC score	0.011188 (rank : 423)
Query Neighborhood Hits	453	Target Neighborhood Hits	444	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

CECR2_HUMAN
θ value	6.88961 (rank : 395)	NC score	0.012609 (rank : 409)
Query Neighborhood Hits	453	Target Neighborhood Hits	543	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CHD9_HUMAN
θ value	6.88961 (rank : 396)	NC score	0.008966 (rank : 444)
Query Neighborhood Hits	453	Target Neighborhood Hits	343	Shared Neighborhood Hits	29
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

DYHC_HUMAN
θ value	6.88961 (rank : 397)	NC score	0.007615 (rank : 456)
Query Neighborhood Hits	453	Target Neighborhood Hits	733	Shared Neighborhood Hits	21
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	6.88961 (rank : 398)	NC score	0.007703 (rank : 455)
Query Neighborhood Hits	453	Target Neighborhood Hits	729	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

EFS_HUMAN
θ value	6.88961 (rank : 399)	NC score	0.036029 (rank : 305)
Query Neighborhood Hits	453	Target Neighborhood Hits	348	Shared Neighborhood Hits	43
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EPN1_MOUSE
θ value	6.88961 (rank : 400)	NC score	0.018393 (rank : 378)
Query Neighborhood Hits	453	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

FA13C_HUMAN
θ value	6.88961 (rank : 401)	NC score	0.013611 (rank : 403)
Query Neighborhood Hits	453	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NE31, Q99787	Gene names	FAM13C1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

FIGLA_HUMAN
θ value	6.88961 (rank : 402)	NC score	0.003527 (rank : 481)
Query Neighborhood Hits	453	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

G3BP_MOUSE
θ value	6.88961 (rank : 403)	NC score	0.007815 (rank : 452)
Query Neighborhood Hits	453	Target Neighborhood Hits	209	Shared Neighborhood Hits	21
SwissProt Accessions	P97855	Gene names	G3bp, G3bp1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

HIPK1_MOUSE
θ value	6.88961 (rank : 404)	NC score	0.005447 (rank : 468)
Query Neighborhood Hits	453	Target Neighborhood Hits	838	Shared Neighborhood Hits	30
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HNRL1_HUMAN
θ value	6.88961 (rank : 405)	NC score	0.024667 (rank : 357)
Query Neighborhood Hits	453	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

KAP1_HUMAN
θ value	6.88961 (rank : 406)	NC score	0.004216 (rank : 479)
Query Neighborhood Hits	453	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

LBR_HUMAN
θ value	6.88961 (rank : 407)	NC score	0.005776 (rank : 465)
Query Neighborhood Hits	453	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q14739, Q14740, Q53GU7, Q59FE6	Gene names	LBR
Domain Architecture
Description	Lamin-B receptor (Integral nuclear envelope inner membrane protein) (LMN2R).

LRC8E_HUMAN
θ value	6.88961 (rank : 408)	NC score	0.030318 (rank : 329)
Query Neighborhood Hits	453	Target Neighborhood Hits	259	Shared Neighborhood Hits	12
SwissProt Accessions	Q6NSJ5, Q2YDY3, Q7L236, Q8N3B0, Q9H5H8	Gene names	LRRC8E
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

MTR1L_HUMAN
θ value	6.88961 (rank : 409)	NC score	-0.005280 (rank : 502)
Query Neighborhood Hits	453	Target Neighborhood Hits	1180	Shared Neighborhood Hits	49
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

NOS3_HUMAN
θ value	6.88961 (rank : 410)	NC score	0.011320 (rank : 421)
Query Neighborhood Hits	453	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

OGFR_HUMAN
θ value	6.88961 (rank : 411)	NC score	0.040601 (rank : 287)
Query Neighborhood Hits	453	Target Neighborhood Hits	1582	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PDLI1_HUMAN
θ value	6.88961 (rank : 412)	NC score	0.153195 (rank : 178)
Query Neighborhood Hits	453	Target Neighborhood Hits	242	Shared Neighborhood Hits	95
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PI3R4_MOUSE
θ value	6.88961 (rank : 413)	NC score	0.005127 (rank : 472)
Query Neighborhood Hits	453	Target Neighborhood Hits	535	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PRP4B_HUMAN
θ value	6.88961 (rank : 414)	NC score	0.011005 (rank : 426)
Query Neighborhood Hits	453	Target Neighborhood Hits	1030	Shared Neighborhood Hits	50
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

REPS2_MOUSE
θ value	6.88961 (rank : 415)	NC score	0.008201 (rank : 451)
Query Neighborhood Hits	453	Target Neighborhood Hits	102	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SLIK5_HUMAN
θ value	6.88961 (rank : 416)	NC score	0.010002 (rank : 437)
Query Neighborhood Hits	453	Target Neighborhood Hits	302	Shared Neighborhood Hits	16
SwissProt Accessions	O94991	Gene names	SLITRK5, KIAA0918, LRRC11
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

SNUT3_MOUSE
θ value	6.88961 (rank : 417)	NC score	0.028432 (rank : 339)
Query Neighborhood Hits	453	Target Neighborhood Hits	50	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K194, Q8BRA8, Q9CSV0	Gene names
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 3.

TRHY_HUMAN
θ value	6.88961 (rank : 418)	NC score	0.016047 (rank : 392)
Query Neighborhood Hits	453	Target Neighborhood Hits	1385	Shared Neighborhood Hits	64
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ZEP2_HUMAN
θ value	6.88961 (rank : 419)	NC score	0.006895 (rank : 459)
Query Neighborhood Hits	453	Target Neighborhood Hits	937	Shared Neighborhood Hits	61
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ANR11_HUMAN
θ value	8.99809 (rank : 420)	NC score	0.016874 (rank : 388)
Query Neighborhood Hits	453	Target Neighborhood Hits	1289	Shared Neighborhood Hits	96
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ATX2L_HUMAN
θ value	8.99809 (rank : 421)	NC score	0.045578 (rank : 272)
Query Neighborhood Hits	453	Target Neighborhood Hits	443	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

CCAR1_MOUSE
θ value	8.99809 (rank : 422)	NC score	0.011518 (rank : 417)
Query Neighborhood Hits	453	Target Neighborhood Hits	414	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

CD2AP_MOUSE
θ value	8.99809 (rank : 423)	NC score	0.028989 (rank : 335)
Query Neighborhood Hits	453	Target Neighborhood Hits	336	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CELR3_MOUSE
θ value	8.99809 (rank : 424)	NC score	-0.005742 (rank : 504)
Query Neighborhood Hits	453	Target Neighborhood Hits	687	Shared Neighborhood Hits	16
SwissProt Accessions	Q91ZI0, Q9ESD0	Gene names	Celsr3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor.

DACH2_HUMAN
θ value	8.99809 (rank : 425)	NC score	0.003573 (rank : 480)
Query Neighborhood Hits	453	Target Neighborhood Hits	122	Shared Neighborhood Hits	4
SwissProt Accessions	Q96NX9, Q8NAY3, Q8ND17, Q96N55	Gene names	DACH2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

DACT1_HUMAN
θ value	8.99809 (rank : 426)	NC score	0.018679 (rank : 377)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

DDX20_HUMAN
θ value	8.99809 (rank : 427)	NC score	0.000294 (rank : 490)
Query Neighborhood Hits	453	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

ESCO1_MOUSE
θ value	8.99809 (rank : 428)	NC score	0.005342 (rank : 470)
Query Neighborhood Hits	453	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q69Z69, Q8BQI2, Q8BR47, Q922F5	Gene names	Esco1, Kiaa1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1).

F103A_HUMAN
θ value	8.99809 (rank : 429)	NC score	0.010485 (rank : 432)
Query Neighborhood Hits	453	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTL3, Q2M1J8	Gene names	FAM103A1, C15orf18
Domain Architecture	No domain graphic available
Description	Protein FAM103A1.

GAK5_HUMAN
θ value	8.99809 (rank : 430)	NC score	0.011489 (rank : 418)
Query Neighborhood Hits	453	Target Neighborhood Hits	429	Shared Neighborhood Hits	47
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GRASP_HUMAN
θ value	8.99809 (rank : 431)	NC score	0.235259 (rank : 141)
Query Neighborhood Hits	453	Target Neighborhood Hits	147	Shared Neighborhood Hits	116
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	8.99809 (rank : 432)	NC score	0.231367 (rank : 142)
Query Neighborhood Hits	453	Target Neighborhood Hits	131	Shared Neighborhood Hits	114
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GTF2I_HUMAN
θ value	8.99809 (rank : 433)	NC score	0.007779 (rank : 454)
Query Neighborhood Hits	453	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

HXD4_MOUSE
θ value	8.99809 (rank : 434)	NC score	-0.001359 (rank : 495)
Query Neighborhood Hits	453	Target Neighborhood Hits	339	Shared Neighborhood Hits	13
SwissProt Accessions	P10628, P97451, Q3UXL6	Gene names	Hoxd4, Hox-4.2, Hoxd-4
Domain Architecture
Description	Homeobox protein Hox-D4 (Hox-4.2) (Hox-5.1).

INP5E_HUMAN
θ value	8.99809 (rank : 435)	NC score	0.009055 (rank : 443)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

K1688_MOUSE
θ value	8.99809 (rank : 436)	NC score	0.011422 (rank : 420)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	24
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

LOXL1_HUMAN
θ value	8.99809 (rank : 437)	NC score	0.004551 (rank : 478)
Query Neighborhood Hits	453	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

MUCDL_HUMAN
θ value	8.99809 (rank : 438)	NC score	0.025444 (rank : 353)
Query Neighborhood Hits	453	Target Neighborhood Hits	777	Shared Neighborhood Hits	81
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MYO1E_HUMAN
θ value	8.99809 (rank : 439)	NC score	0.007593 (rank : 457)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	29
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NUCL_HUMAN
θ value	8.99809 (rank : 440)	NC score	0.005178 (rank : 471)
Query Neighborhood Hits	453	Target Neighborhood Hits	415	Shared Neighborhood Hits	33
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

PDLI7_HUMAN
θ value	8.99809 (rank : 441)	NC score	0.128654 (rank : 188)
Query Neighborhood Hits	453	Target Neighborhood Hits	547	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SALL3_HUMAN
θ value	8.99809 (rank : 442)	NC score	0.000569 (rank : 489)
Query Neighborhood Hits	453	Target Neighborhood Hits	1066	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SIG10_HUMAN
θ value	8.99809 (rank : 443)	NC score	0.003292 (rank : 482)
Query Neighborhood Hits	453	Target Neighborhood Hits	363	Shared Neighborhood Hits	23
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

SPEG_MOUSE
θ value	8.99809 (rank : 444)	NC score	0.017004 (rank : 385)
Query Neighborhood Hits	453	Target Neighborhood Hits	1959	Shared Neighborhood Hits	152
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SRC8_HUMAN
θ value	8.99809 (rank : 445)	NC score	0.008903 (rank : 445)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	21
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STXB4_MOUSE
θ value	8.99809 (rank : 446)	NC score	0.263223 (rank : 126)
Query Neighborhood Hits	453	Target Neighborhood Hits	629	Shared Neighborhood Hits	104
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SYNP2_MOUSE
θ value	8.99809 (rank : 447)	NC score	0.206377 (rank : 156)
Query Neighborhood Hits	453	Target Neighborhood Hits	252	Shared Neighborhood Hits	132
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYT6_HUMAN
θ value	8.99809 (rank : 448)	NC score	0.005012 (rank : 473)
Query Neighborhood Hits	453	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

TBX15_HUMAN
θ value	8.99809 (rank : 449)	NC score	0.001205 (rank : 485)
Query Neighborhood Hits	453	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q96SF7, Q5T9S7	Gene names	TBX15, TBX14
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX15 (T-box protein 15).

YETS2_MOUSE
θ value	8.99809 (rank : 450)	NC score	0.012407 (rank : 411)
Query Neighborhood Hits	453	Target Neighborhood Hits	278	Shared Neighborhood Hits	29
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ZKSC1_MOUSE
θ value	8.99809 (rank : 451)	NC score	-0.006285 (rank : 505)
Query Neighborhood Hits	453	Target Neighborhood Hits	755	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGS3, Q7TS88, Q8BJ55, Q9CRN6	Gene names	Zkscan1
Domain Architecture	No domain graphic available
Description	Zinc finger with KRAB and SCAN domain-containing protein 1.

ZN409_HUMAN
θ value	8.99809 (rank : 452)	NC score	0.006133 (rank : 464)
Query Neighborhood Hits	453	Target Neighborhood Hits	842	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

ZN462_HUMAN
θ value	8.99809 (rank : 453)	NC score	-0.004477 (rank : 501)
Query Neighborhood Hits	453	Target Neighborhood Hits	740	Shared Neighborhood Hits	18
SwissProt Accessions	Q96JM2, Q8N408	Gene names	ZNF462, KIAA1803
Domain Architecture	No domain graphic available
Description	Zinc finger protein 462.

APXL_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.175315 (rank : 169)
Query Neighborhood Hits	453	Target Neighborhood Hits	553	Shared Neighborhood Hits	128
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CACB1_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.069497 (rank : 212)
Query Neighborhood Hits	453	Target Neighborhood Hits	44	Shared Neighborhood Hits	21
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB1_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.073086 (rank : 207)
Query Neighborhood Hits	453	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

CACB2_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.051558 (rank : 258)
Query Neighborhood Hits	453	Target Neighborhood Hits	99	Shared Neighborhood Hits	22
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

CACB3_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.066826 (rank : 217)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.066182 (rank : 218)
Query Neighborhood Hits	453	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CACB4_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.067614 (rank : 216)
Query Neighborhood Hits	453	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB4_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.065531 (rank : 220)
Query Neighborhood Hits	453	Target Neighborhood Hits	42	Shared Neighborhood Hits	19
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CARD9_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.052906 (rank : 251)
Query Neighborhood Hits	453	Target Neighborhood Hits	602	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CNKR2_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.072683 (rank : 210)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.072789 (rank : 209)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CRK_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.067805 (rank : 214)
Query Neighborhood Hits	453	Target Neighborhood Hits	308	Shared Neighborhood Hits	36
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.067791 (rank : 215)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	37
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GIPC1_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.138846 (rank : 185)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	78
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

GIPC1_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.144634 (rank : 181)
Query Neighborhood Hits	453	Target Neighborhood Hits	92	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC2_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.107468 (rank : 195)
Query Neighborhood Hits	453	Target Neighborhood Hits	93	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GIPC2_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.062388 (rank : 227)
Query Neighborhood Hits	453	Target Neighborhood Hits	71	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.062678 (rank : 226)
Query Neighborhood Hits	453	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.063205 (rank : 224)
Query Neighborhood Hits	453	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GRB2_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.062143 (rank : 228)
Query Neighborhood Hits	453	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.062846 (rank : 225)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

KGUA_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.308801 (rank : 112)
Query Neighborhood Hits	453	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.313987 (rank : 110)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	30
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LRRC1_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.053660 (rank : 249)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

LRRC1_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.053611 (rank : 250)
Query Neighborhood Hits	453	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

NOS1_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.179377 (rank : 167)
Query Neighborhood Hits	453	Target Neighborhood Hits	155	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PAR6A_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.238694 (rank : 139)
Query Neighborhood Hits	453	Target Neighborhood Hits	119	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.238910 (rank : 138)
Query Neighborhood Hits	453	Target Neighborhood Hits	115	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6G_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.252320 (rank : 131)
Query Neighborhood Hits	453	Target Neighborhood Hits	159	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.250328 (rank : 133)
Query Neighborhood Hits	453	Target Neighborhood Hits	121	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDLI1_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.147296 (rank : 179)
Query Neighborhood Hits	453	Target Neighborhood Hits	213	Shared Neighborhood Hits	93
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI4_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.160367 (rank : 176)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	106
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI7_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.103975 (rank : 197)
Query Neighborhood Hits	453	Target Neighborhood Hits	279	Shared Neighborhood Hits	104
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZD6_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.114303 (rank : 193)
Query Neighborhood Hits	453	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PRG4_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.055026 (rank : 245)
Query Neighborhood Hits	453	Target Neighborhood Hits	764	Shared Neighborhood Hits	106
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PROP_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.059138 (rank : 233)
Query Neighborhood Hits	453	Target Neighborhood Hits	126	Shared Neighborhood Hits	9
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.056498 (rank : 241)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

PSCBP_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.217677 (rank : 149)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	106
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

RIMS1_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.180852 (rank : 166)
Query Neighborhood Hits	453	Target Neighborhood Hits	437	Shared Neighborhood Hits	147
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RNF41_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.058910 (rank : 235)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.059033 (rank : 234)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

SHAN2_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.175476 (rank : 168)
Query Neighborhood Hits	453	Target Neighborhood Hits	346	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.155779 (rank : 177)
Query Neighborhood Hits	453	Target Neighborhood Hits	446	Shared Neighborhood Hits	154
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRRM2_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.063827 (rank : 222)
Query Neighborhood Hits	453	Target Neighborhood Hits	1296	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.063899 (rank : 221)
Query Neighborhood Hits	453	Target Neighborhood Hits	1470	Shared Neighborhood Hits	163
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

STAM1_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.052049 (rank : 255)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	35
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.060439 (rank : 232)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	38
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.053768 (rank : 248)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	33
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TARA_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.057685 (rank : 237)
Query Neighborhood Hits	453	Target Neighborhood Hits	1626	Shared Neighborhood Hits	148
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TGON2_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.055919 (rank : 243)
Query Neighborhood Hits	453	Target Neighborhood Hits	1037	Shared Neighborhood Hits	112
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

WASIP_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.054290 (rank : 246)
Query Neighborhood Hits	453	Target Neighborhood Hits	458	Shared Neighborhood Hits	84
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

YLPM1_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.050669 (rank : 261)
Query Neighborhood Hits	453	Target Neighborhood Hits	505	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

Hits sorted by NC score

ZO1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	453	Target Neighborhood Hits	453	Shared Neighborhood Hits	453
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_HUMAN
NC score	0.975693 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	453	Target Neighborhood Hits	474	Shared Neighborhood Hits	280
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO3_HUMAN
NC score	0.919726 (rank : 3)	θ value	9.45368e-175 (rank : 5)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	183
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO2_MOUSE
NC score	0.919141 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
NC score	0.915294 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	185
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO3_MOUSE
NC score	0.915270 (rank : 6)	θ value	6.35588e-163 (rank : 6)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	184
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

DLG4_MOUSE
NC score	0.724002 (rank : 7)	θ value	3.06405e-32 (rank : 12)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	176
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.723182 (rank : 8)	θ value	4.00176e-32 (rank : 13)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	176
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG2_HUMAN
NC score	0.718466 (rank : 9)	θ value	2.12192e-33 (rank : 9)
Query Neighborhood Hits	453	Target Neighborhood Hits	279	Shared Neighborhood Hits	173
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
NC score	0.718309 (rank : 10)	θ value	1.0531e-32 (rank : 11)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	171
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
NC score	0.716147 (rank : 11)	θ value	6.82597e-32 (rank : 14)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	172
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG1_MOUSE
NC score	0.715810 (rank : 12)	θ value	1.6247e-33 (rank : 8)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	169
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG3_MOUSE
NC score	0.714854 (rank : 13)	θ value	3.74554e-30 (rank : 15)
Query Neighborhood Hits	453	Target Neighborhood Hits	274	Shared Neighborhood Hits	172
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_HUMAN
NC score	0.714635 (rank : 14)	θ value	6.17384e-33 (rank : 10)
Query Neighborhood Hits	453	Target Neighborhood Hits	290	Shared Neighborhood Hits	171
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

SYJ2B_HUMAN
NC score	0.649357 (rank : 15)	θ value	1.29631e-06 (rank : 54)
Query Neighborhood Hits	453	Target Neighborhood Hits	162	Shared Neighborhood Hits	148
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

INADL_MOUSE
NC score	0.643223 (rank : 16)	θ value	8.65492e-19 (rank : 16)
Query Neighborhood Hits	453	Target Neighborhood Hits	290	Shared Neighborhood Hits	186
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

INADL_HUMAN
NC score	0.626397 (rank : 17)	θ value	3.63628e-17 (rank : 17)
Query Neighborhood Hits	453	Target Neighborhood Hits	260	Shared Neighborhood Hits	176
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MPDZ_MOUSE
NC score	0.607698 (rank : 18)	θ value	1.09485e-13 (rank : 23)
Query Neighborhood Hits	453	Target Neighborhood Hits	298	Shared Neighborhood Hits	184
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MPDZ_HUMAN
NC score	0.607007 (rank : 19)	θ value	4.91457e-14 (rank : 21)
Query Neighborhood Hits	453	Target Neighborhood Hits	261	Shared Neighborhood Hits	180
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PDZ11_MOUSE
NC score	0.596319 (rank : 20)	θ value	2.61198e-07 (rank : 50)
Query Neighborhood Hits	453	Target Neighborhood Hits	154	Shared Neighborhood Hits	136
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_HUMAN
NC score	0.595170 (rank : 21)	θ value	5.81887e-07 (rank : 51)
Query Neighborhood Hits	453	Target Neighborhood Hits	160	Shared Neighborhood Hits	140
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

USH1C_HUMAN
NC score	0.572107 (rank : 22)	θ value	4.76016e-09 (rank : 42)
Query Neighborhood Hits	453	Target Neighborhood Hits	327	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZD2_HUMAN
NC score	0.562017 (rank : 23)	θ value	1.47974e-10 (rank : 35)
Query Neighborhood Hits	453	Target Neighborhood Hits	772	Shared Neighborhood Hits	222
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

LNX2_MOUSE
NC score	0.558344 (rank : 24)	θ value	6.64225e-11 (rank : 32)
Query Neighborhood Hits	453	Target Neighborhood Hits	407	Shared Neighborhood Hits	173
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

WHRN_HUMAN
NC score	0.558326 (rank : 25)	θ value	6.43352e-06 (rank : 65)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	190
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.553055 (rank : 26)	θ value	3.77169e-06 (rank : 61)
Query Neighborhood Hits	453	Target Neighborhood Hits	412	Shared Neighborhood Hits	192
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZD7_HUMAN
NC score	0.548297 (rank : 27)	θ value	0.0113563 (rank : 125)
Query Neighborhood Hits	453	Target Neighborhood Hits	181	Shared Neighborhood Hits	158
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

LNX1_MOUSE
NC score	0.546004 (rank : 28)	θ value	8.97725e-08 (rank : 48)
Query Neighborhood Hits	453	Target Neighborhood Hits	377	Shared Neighborhood Hits	167
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

GRIP2_HUMAN
NC score	0.544239 (rank : 29)	θ value	4.1701e-05 (rank : 71)
Query Neighborhood Hits	453	Target Neighborhood Hits	256	Shared Neighborhood Hits	175
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

LNX2_HUMAN
NC score	0.541510 (rank : 30)	θ value	3.64472e-09 (rank : 41)
Query Neighborhood Hits	453	Target Neighborhood Hits	389	Shared Neighborhood Hits	170
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX1_HUMAN
NC score	0.540485 (rank : 31)	θ value	1.80886e-08 (rank : 44)
Query Neighborhood Hits	453	Target Neighborhood Hits	379	Shared Neighborhood Hits	158
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

GRIP1_HUMAN
NC score	0.535923 (rank : 32)	θ value	9.29e-05 (rank : 81)
Query Neighborhood Hits	453	Target Neighborhood Hits	231	Shared Neighborhood Hits	174
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
NC score	0.533532 (rank : 33)	θ value	0.000121331 (rank : 87)
Query Neighborhood Hits	453	Target Neighborhood Hits	241	Shared Neighborhood Hits	179
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DLG5_HUMAN
NC score	0.532698 (rank : 34)	θ value	3.27365e-34 (rank : 7)
Query Neighborhood Hits	453	Target Neighborhood Hits	1088	Shared Neighborhood Hits	204
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

TX1B3_HUMAN
NC score	0.532487 (rank : 35)	θ value	0.00390308 (rank : 113)
Query Neighborhood Hits	453	Target Neighborhood Hits	161	Shared Neighborhood Hits	146
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

MPP5_HUMAN
NC score	0.531314 (rank : 36)	θ value	1.42992e-13 (rank : 24)
Query Neighborhood Hits	453	Target Neighborhood Hits	231	Shared Neighborhood Hits	132
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

LIN7C_HUMAN
NC score	0.531049 (rank : 37)	θ value	0.00390308 (rank : 111)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	171
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.531049 (rank : 38)	θ value	0.00390308 (rank : 112)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	171
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

PAR3L_HUMAN
NC score	0.530881 (rank : 39)	θ value	3.77169e-06 (rank : 60)
Query Neighborhood Hits	453	Target Neighborhood Hits	297	Shared Neighborhood Hits	152
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

LIN7B_HUMAN
NC score	0.530803 (rank : 40)	θ value	0.0113563 (rank : 124)
Query Neighborhood Hits	453	Target Neighborhood Hits	200	Shared Neighborhood Hits	173
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MPP5_MOUSE
NC score	0.530498 (rank : 41)	θ value	6.41864e-14 (rank : 22)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MAGI1_HUMAN
NC score	0.530096 (rank : 42)	θ value	1.74796e-11 (rank : 30)
Query Neighborhood Hits	453	Target Neighborhood Hits	388	Shared Neighborhood Hits	197
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

TX1B3_MOUSE
NC score	0.529620 (rank : 43)	θ value	0.00390308 (rank : 114)
Query Neighborhood Hits	453	Target Neighborhood Hits	158	Shared Neighborhood Hits	143
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_MOUSE
NC score	0.528417 (rank : 44)	θ value	6.43352e-06 (rank : 64)
Query Neighborhood Hits	453	Target Neighborhood Hits	557	Shared Neighborhood Hits	201
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

LIN7B_MOUSE
NC score	0.528329 (rank : 45)	θ value	0.0148317 (rank : 129)
Query Neighborhood Hits	453	Target Neighborhood Hits	200	Shared Neighborhood Hits	173
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

IL16_HUMAN
NC score	0.526629 (rank : 46)	θ value	5.44631e-05 (rank : 76)
Query Neighborhood Hits	453	Target Neighborhood Hits	207	Shared Neighborhood Hits	147
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

MAGI1_MOUSE
NC score	0.525584 (rank : 47)	θ value	2.52405e-10 (rank : 37)
Query Neighborhood Hits	453	Target Neighborhood Hits	403	Shared Neighborhood Hits	200
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

LIN7A_HUMAN
NC score	0.523127 (rank : 48)	θ value	0.0252991 (rank : 135)
Query Neighborhood Hits	453	Target Neighborhood Hits	193	Shared Neighborhood Hits	170
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.523059 (rank : 49)	θ value	0.0252991 (rank : 136)
Query Neighborhood Hits	453	Target Neighborhood Hits	193	Shared Neighborhood Hits	170
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

PARD3_HUMAN
NC score	0.514787 (rank : 50)	θ value	0.000786445 (rank : 98)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	160
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

GOPC_MOUSE
NC score	0.511054 (rank : 51)	θ value	0.000121331 (rank : 86)
Query Neighborhood Hits	453	Target Neighborhood Hits	323	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

MAGI2_MOUSE
NC score	0.510324 (rank : 52)	θ value	4.0297e-08 (rank : 47)
Query Neighborhood Hits	453	Target Neighborhood Hits	370	Shared Neighborhood Hits	189
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PARD3_MOUSE
NC score	0.509432 (rank : 53)	θ value	0.0148317 (rank : 131)
Query Neighborhood Hits	453	Target Neighborhood Hits	290	Shared Neighborhood Hits	161
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

SNTG2_HUMAN
NC score	0.507835 (rank : 54)	θ value	9.92553e-07 (rank : 53)
Query Neighborhood Hits	453	Target Neighborhood Hits	191	Shared Neighborhood Hits	161
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

MAGI2_HUMAN
NC score	0.503015 (rank : 55)	θ value	1.69304e-06 (rank : 55)
Query Neighborhood Hits	453	Target Neighborhood Hits	373	Shared Neighborhood Hits	188
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

IL16_MOUSE
NC score	0.502640 (rank : 56)	θ value	0.00175202 (rank : 107)
Query Neighborhood Hits	453	Target Neighborhood Hits	189	Shared Neighborhood Hits	138
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

GOPC_HUMAN
NC score	0.502128 (rank : 57)	θ value	0.000121331 (rank : 85)
Query Neighborhood Hits	453	Target Neighborhood Hits	377	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PDZD1_MOUSE
NC score	0.499318 (rank : 58)	θ value	3.19293e-05 (rank : 70)
Query Neighborhood Hits	453	Target Neighborhood Hits	191	Shared Neighborhood Hits	152
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PZRN4_HUMAN
NC score	0.493246 (rank : 59)	θ value	1.38499e-08 (rank : 43)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	153
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PZRN3_HUMAN
NC score	0.491863 (rank : 60)	θ value	1.63604e-09 (rank : 38)
Query Neighborhood Hits	453	Target Neighborhood Hits	461	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
NC score	0.490479 (rank : 61)	θ value	1.63604e-09 (rank : 39)
Query Neighborhood Hits	453	Target Neighborhood Hits	447	Shared Neighborhood Hits	155
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDZD1_HUMAN
NC score	0.487909 (rank : 62)	θ value	0.00102713 (rank : 101)
Query Neighborhood Hits	453	Target Neighborhood Hits	190	Shared Neighborhood Hits	149
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SNTB2_MOUSE
NC score	0.481568 (rank : 63)	θ value	0.00134147 (rank : 104)
Query Neighborhood Hits	453	Target Neighborhood Hits	181	Shared Neighborhood Hits	149
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG2_MOUSE
NC score	0.481436 (rank : 64)	θ value	1.69304e-06 (rank : 57)
Query Neighborhood Hits	453	Target Neighborhood Hits	176	Shared Neighborhood Hits	149
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTB2_HUMAN
NC score	0.480501 (rank : 65)	θ value	0.00134147 (rank : 103)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	149
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTA1_HUMAN
NC score	0.477284 (rank : 66)	θ value	9.92553e-07 (rank : 52)
Query Neighborhood Hits	453	Target Neighborhood Hits	186	Shared Neighborhood Hits	154
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
NC score	0.472930 (rank : 67)	θ value	1.69304e-06 (rank : 56)
Query Neighborhood Hits	453	Target Neighborhood Hits	170	Shared Neighborhood Hits	148
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTG1_MOUSE
NC score	0.462923 (rank : 68)	θ value	5.44631e-05 (rank : 77)
Query Neighborhood Hits	453	Target Neighborhood Hits	179	Shared Neighborhood Hits	152
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
NC score	0.462899 (rank : 69)	θ value	9.29e-05 (rank : 83)
Query Neighborhood Hits	453	Target Neighborhood Hits	181	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTB1_HUMAN
NC score	0.459130 (rank : 70)	θ value	0.000158464 (rank : 89)
Query Neighborhood Hits	453	Target Neighborhood Hits	157	Shared Neighborhood Hits	138
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.458317 (rank : 71)	θ value	4.1701e-05 (rank : 73)
Query Neighborhood Hits	453	Target Neighborhood Hits	160	Shared Neighborhood Hits	136
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

NHERF_MOUSE
NC score	0.450796 (rank : 72)	θ value	3.19293e-05 (rank : 69)
Query Neighborhood Hits	453	Target Neighborhood Hits	195	Shared Neighborhood Hits	151
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

EM55_MOUSE
NC score	0.445569 (rank : 73)	θ value	2.79066e-09 (rank : 40)
Query Neighborhood Hits	453	Target Neighborhood Hits	221	Shared Neighborhood Hits	114
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MPP3_HUMAN
NC score	0.443988 (rank : 74)	θ value	0.000602161 (rank : 93)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	121
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PDZD3_HUMAN
NC score	0.439926 (rank : 75)	θ value	0.0563607 (rank : 145)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	154
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

MPP3_MOUSE
NC score	0.439331 (rank : 76)	θ value	0.000786445 (rank : 97)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

EM55_HUMAN
NC score	0.436352 (rank : 77)	θ value	2.21117e-06 (rank : 59)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	116
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

NHRF2_HUMAN
NC score	0.427625 (rank : 78)	θ value	0.0961366 (rank : 161)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	162
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHERF_HUMAN
NC score	0.427052 (rank : 79)	θ value	0.0193708 (rank : 133)
Query Neighborhood Hits	453	Target Neighborhood Hits	190	Shared Neighborhood Hits	153
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

MPP2_MOUSE
NC score	0.425490 (rank : 80)	θ value	1.87187e-05 (rank : 67)
Query Neighborhood Hits	453	Target Neighborhood Hits	189	Shared Neighborhood Hits	98
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP2_HUMAN
NC score	0.422020 (rank : 81)	θ value	9.29e-05 (rank : 82)
Query Neighborhood Hits	453	Target Neighborhood Hits	173	Shared Neighborhood Hits	90
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP6_HUMAN
NC score	0.415409 (rank : 82)	θ value	0.000121331 (rank : 88)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP4_HUMAN
NC score	0.411240 (rank : 83)	θ value	1.81305 (rank : 258)
Query Neighborhood Hits	453	Target Neighborhood Hits	205	Shared Neighborhood Hits	131
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

LAP4_HUMAN
NC score	0.410018 (rank : 84)	θ value	4.59992e-12 (rank : 27)
Query Neighborhood Hits	453	Target Neighborhood Hits	608	Shared Neighborhood Hits	202
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

NHRF2_MOUSE
NC score	0.409869 (rank : 85)	θ value	1.81305 (rank : 259)
Query Neighborhood Hits	453	Target Neighborhood Hits	194	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

MPP6_MOUSE
NC score	0.408138 (rank : 86)	θ value	0.00228821 (rank : 110)
Query Neighborhood Hits	453	Target Neighborhood Hits	187	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

LAP4_MOUSE
NC score	0.406765 (rank : 87)	θ value	6.00763e-12 (rank : 28)
Query Neighborhood Hits	453	Target Neighborhood Hits	590	Shared Neighborhood Hits	197
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PDZK4_HUMAN
NC score	0.403510 (rank : 88)	θ value	2.44474e-05 (rank : 68)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	120
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
NC score	0.400499 (rank : 89)	θ value	7.1131e-05 (rank : 80)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZD3_MOUSE
NC score	0.396023 (rank : 90)	θ value	0.365318 (rank : 195)
Query Neighborhood Hits	453	Target Neighborhood Hits	171	Shared Neighborhood Hits	150
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

K1849_HUMAN
NC score	0.392177 (rank : 91)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	132
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MPP4_MOUSE
NC score	0.391661 (rank : 92)	θ value	0.0961366 (rank : 160)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	110
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

K1849_MOUSE
NC score	0.389732 (rank : 93)	θ value	0.00175202 (rank : 108)
Query Neighborhood Hits	453	Target Neighborhood Hits	335	Shared Neighborhood Hits	145
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PTN13_HUMAN
NC score	0.364484 (rank : 94)	θ value	1.02475e-11 (rank : 29)
Query Neighborhood Hits	453	Target Neighborhood Hits	471	Shared Neighborhood Hits	178
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

DVL3_HUMAN
NC score	0.364025 (rank : 95)	θ value	0.0113563 (rank : 122)
Query Neighborhood Hits	453	Target Neighborhood Hits	194	Shared Neighborhood Hits	117
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
NC score	0.363867 (rank : 96)	θ value	0.0113563 (rank : 123)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	119
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PTN13_MOUSE
NC score	0.360473 (rank : 97)	θ value	3.07829e-16 (rank : 18)
Query Neighborhood Hits	453	Target Neighborhood Hits	426	Shared Neighborhood Hits	173
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

DVL1_HUMAN
NC score	0.359458 (rank : 98)	θ value	0.0148317 (rank : 126)
Query Neighborhood Hits	453	Target Neighborhood Hits	158	Shared Neighborhood Hits	115
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

SDCB1_MOUSE
NC score	0.356644 (rank : 99)	θ value	0.0330416 (rank : 140)
Query Neighborhood Hits	453	Target Neighborhood Hits	144	Shared Neighborhood Hits	129
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

DVL1_MOUSE
NC score	0.356005 (rank : 100)	θ value	0.0193708 (rank : 132)
Query Neighborhood Hits	453	Target Neighborhood Hits	146	Shared Neighborhood Hits	113
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

SDCB1_HUMAN
NC score	0.355331 (rank : 101)	θ value	0.0563607 (rank : 146)
Query Neighborhood Hits	453	Target Neighborhood Hits	150	Shared Neighborhood Hits	133
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

DVL1L_HUMAN
NC score	0.348922 (rank : 102)	θ value	0.00665767 (rank : 117)
Query Neighborhood Hits	453	Target Neighborhood Hits	146	Shared Neighborhood Hits	113
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_MOUSE
NC score	0.347842 (rank : 103)	θ value	0.00175202 (rank : 106)
Query Neighborhood Hits	453	Target Neighborhood Hits	233	Shared Neighborhood Hits	121
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.347573 (rank : 104)	θ value	0.00665767 (rank : 118)
Query Neighborhood Hits	453	Target Neighborhood Hits	223	Shared Neighborhood Hits	119
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

NEB1_HUMAN
NC score	0.345654 (rank : 105)	θ value	0.000461057 (rank : 92)
Query Neighborhood Hits	453	Target Neighborhood Hits	829	Shared Neighborhood Hits	139
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

AFAD_HUMAN
NC score	0.343975 (rank : 106)	θ value	1.81305 (rank : 248)
Query Neighborhood Hits	453	Target Neighborhood Hits	689	Shared Neighborhood Hits	169
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

NEB2_HUMAN
NC score	0.337741 (rank : 107)	θ value	7.1131e-05 (rank : 78)
Query Neighborhood Hits	453	Target Neighborhood Hits	883	Shared Neighborhood Hits	142
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.333055 (rank : 108)	θ value	7.1131e-05 (rank : 79)
Query Neighborhood Hits	453	Target Neighborhood Hits	889	Shared Neighborhood Hits	138
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

RPGF6_HUMAN
NC score	0.326954 (rank : 109)	θ value	0.000786445 (rank : 100)
Query Neighborhood Hits	453	Target Neighborhood Hits	266	Shared Neighborhood Hits	154
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

KGUA_MOUSE
NC score	0.313987 (rank : 110)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	30
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

APBA1_HUMAN
NC score	0.309399 (rank : 111)	θ value	5.27518 (rank : 346)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	152
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

KGUA_HUMAN
NC score	0.308801 (rank : 112)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	453	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

SDCB2_MOUSE
NC score	0.303396 (rank : 113)	θ value	0.00665767 (rank : 120)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	106
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PDLI2_HUMAN
NC score	0.300542 (rank : 114)	θ value	0.0736092 (rank : 151)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	121
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

APBA3_MOUSE
NC score	0.299612 (rank : 115)	θ value	0.00509761 (rank : 115)
Query Neighborhood Hits	453	Target Neighborhood Hits	174	Shared Neighborhood Hits	123
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PICK1_MOUSE
NC score	0.299453 (rank : 116)	θ value	0.365318 (rank : 197)
Query Neighborhood Hits	453	Target Neighborhood Hits	131	Shared Neighborhood Hits	113
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_HUMAN
NC score	0.297335 (rank : 117)	θ value	0.365318 (rank : 196)
Query Neighborhood Hits	453	Target Neighborhood Hits	132	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RPGF2_HUMAN
NC score	0.282954 (rank : 118)	θ value	0.00665767 (rank : 119)
Query Neighborhood Hits	453	Target Neighborhood Hits	242	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

APBA2_HUMAN
NC score	0.282784 (rank : 119)	θ value	5.27518 (rank : 347)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	136
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
NC score	0.282636 (rank : 120)	θ value	5.27518 (rank : 348)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	136
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
NC score	0.281986 (rank : 121)	θ value	0.0961366 (rank : 158)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	129
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

SDCB2_HUMAN
NC score	0.281065 (rank : 122)	θ value	0.813845 (rank : 222)
Query Neighborhood Hits	453	Target Neighborhood Hits	121	Shared Neighborhood Hits	114
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

STXB4_HUMAN
NC score	0.277284 (rank : 123)	θ value	0.62314 (rank : 213)
Query Neighborhood Hits	453	Target Neighborhood Hits	616	Shared Neighborhood Hits	111
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PDLI2_MOUSE
NC score	0.274523 (rank : 124)	θ value	0.0736092 (rank : 152)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	113
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

SYP2L_HUMAN
NC score	0.271696 (rank : 125)	θ value	0.0330416 (rank : 141)
Query Neighborhood Hits	453	Target Neighborhood Hits	400	Shared Neighborhood Hits	153
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

STXB4_MOUSE
NC score	0.263223 (rank : 126)	θ value	8.99809 (rank : 446)
Query Neighborhood Hits	453	Target Neighborhood Hits	629	Shared Neighborhood Hits	104
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PAR6B_MOUSE
NC score	0.263066 (rank : 127)	θ value	4.03905 (rank : 335)
Query Neighborhood Hits	453	Target Neighborhood Hits	128	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_HUMAN
NC score	0.261481 (rank : 128)	θ value	4.03905 (rank : 334)
Query Neighborhood Hits	453	Target Neighborhood Hits	126	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

ARHGB_HUMAN
NC score	0.259522 (rank : 129)	θ value	0.00869519 (rank : 121)
Query Neighborhood Hits	453	Target Neighborhood Hits	375	Shared Neighborhood Hits	165
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.253455 (rank : 130)	θ value	5.44631e-05 (rank : 75)
Query Neighborhood Hits	453	Target Neighborhood Hits	351	Shared Neighborhood Hits	143
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PAR6G_HUMAN
NC score	0.252320 (rank : 131)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	453	Target Neighborhood Hits	159	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

RHPN1_MOUSE
NC score	0.250860 (rank : 132)	θ value	0.163984 (rank : 175)
Query Neighborhood Hits	453	Target Neighborhood Hits	154	Shared Neighborhood Hits	125
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PAR6G_MOUSE
NC score	0.250328 (rank : 133)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	453	Target Neighborhood Hits	121	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

ARHGC_MOUSE
NC score	0.248302 (rank : 134)	θ value	0.000461057 (rank : 91)
Query Neighborhood Hits	453	Target Neighborhood Hits	344	Shared Neighborhood Hits	144
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CAR14_HUMAN
NC score	0.246740 (rank : 135)	θ value	1.99992e-07 (rank : 49)
Query Neighborhood Hits	453	Target Neighborhood Hits	449	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

LRRC7_HUMAN
NC score	0.246326 (rank : 136)	θ value	4.92598e-06 (rank : 62)
Query Neighborhood Hits	453	Target Neighborhood Hits	423	Shared Neighborhood Hits	124
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.245781 (rank : 137)	θ value	4.92598e-06 (rank : 63)
Query Neighborhood Hits	453	Target Neighborhood Hits	416	Shared Neighborhood Hits	125
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PAR6A_MOUSE
NC score	0.238910 (rank : 138)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	453	Target Neighborhood Hits	115	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.238694 (rank : 139)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	453	Target Neighborhood Hits	119	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

LAP2_HUMAN
NC score	0.237404 (rank : 140)	θ value	1.43324e-05 (rank : 66)
Query Neighborhood Hits	453	Target Neighborhood Hits	499	Shared Neighborhood Hits	126
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

GRASP_HUMAN
NC score	0.235259 (rank : 141)	θ value	8.99809 (rank : 431)
Query Neighborhood Hits	453	Target Neighborhood Hits	147	Shared Neighborhood Hits	116
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
NC score	0.231367 (rank : 142)	θ value	8.99809 (rank : 432)
Query Neighborhood Hits	453	Target Neighborhood Hits	131	Shared Neighborhood Hits	114
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

LAP2_MOUSE
NC score	0.229251 (rank : 143)	θ value	4.1701e-05 (rank : 72)
Query Neighborhood Hits	453	Target Neighborhood Hits	482	Shared Neighborhood Hits	117
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

RHPN1_HUMAN
NC score	0.229145 (rank : 144)	θ value	1.81305 (rank : 265)
Query Neighborhood Hits	453	Target Neighborhood Hits	158	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

UNC5A_HUMAN
NC score	0.226119 (rank : 145)	θ value	1.47974e-10 (rank : 36)
Query Neighborhood Hits	453	Target Neighborhood Hits	198	Shared Neighborhood Hits	15
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CAR11_HUMAN
NC score	0.225198 (rank : 146)	θ value	4.0297e-08 (rank : 45)
Query Neighborhood Hits	453	Target Neighborhood Hits	690	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

NOS1_HUMAN
NC score	0.224107 (rank : 147)	θ value	1.81305 (rank : 260)
Query Neighborhood Hits	453	Target Neighborhood Hits	218	Shared Neighborhood Hits	140
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

CAR14_MOUSE
NC score	0.218022 (rank : 148)	θ value	4.0297e-08 (rank : 46)
Query Neighborhood Hits	453	Target Neighborhood Hits	526	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

PSCBP_MOUSE
NC score	0.217677 (rank : 149)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	106
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

UNC5C_MOUSE
NC score	0.216022 (rank : 150)	θ value	1.68911e-14 (rank : 20)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.215801 (rank : 151)	θ value	1.68911e-14 (rank : 19)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	19
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

PSCBP_HUMAN
NC score	0.213931 (rank : 152)	θ value	1.81305 (rank : 263)
Query Neighborhood Hits	453	Target Neighborhood Hits	123	Shared Neighborhood Hits	108
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

UNC5B_MOUSE
NC score	0.211627 (rank : 153)	θ value	2.0648e-12 (rank : 25)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5B_HUMAN
NC score	0.210536 (rank : 154)	θ value	2.69671e-12 (rank : 26)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

CAR10_MOUSE
NC score	0.206585 (rank : 155)	θ value	2.21117e-06 (rank : 58)
Query Neighborhood Hits	453	Target Neighborhood Hits	407	Shared Neighborhood Hits	29
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

SYNP2_MOUSE
NC score	0.206377 (rank : 156)	θ value	8.99809 (rank : 447)
Query Neighborhood Hits	453	Target Neighborhood Hits	252	Shared Neighborhood Hits	132
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

RGS12_HUMAN
NC score	0.204930 (rank : 157)	θ value	4.03905 (rank : 336)
Query Neighborhood Hits	453	Target Neighborhood Hits	333	Shared Neighborhood Hits	145
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

UNC5A_MOUSE
NC score	0.204842 (rank : 158)	θ value	8.67504e-11 (rank : 33)
Query Neighborhood Hits	453	Target Neighborhood Hits	203	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5D_MOUSE
NC score	0.200765 (rank : 159)	θ value	1.74796e-11 (rank : 31)
Query Neighborhood Hits	453	Target Neighborhood Hits	268	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_HUMAN
NC score	0.199299 (rank : 160)	θ value	1.133e-10 (rank : 34)
Query Neighborhood Hits	453	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

PRAX_MOUSE
NC score	0.199241 (rank : 161)	θ value	0.000602161 (rank : 94)
Query Neighborhood Hits	453	Target Neighborhood Hits	199	Shared Neighborhood Hits	62
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

SYP2L_MOUSE
NC score	0.197006 (rank : 162)	θ value	0.0563607 (rank : 147)
Query Neighborhood Hits	453	Target Neighborhood Hits	289	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PDLI4_MOUSE
NC score	0.185527 (rank : 163)	θ value	1.38821 (rank : 244)
Query Neighborhood Hits	453	Target Neighborhood Hits	233	Shared Neighborhood Hits	105
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PCLO_MOUSE
NC score	0.183104 (rank : 164)	θ value	0.00175202 (rank : 109)
Query Neighborhood Hits	453	Target Neighborhood Hits	2275	Shared Neighborhood Hits	278
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI3_HUMAN
NC score	0.181942 (rank : 165)	θ value	3.0926 (rank : 307)
Query Neighborhood Hits	453	Target Neighborhood Hits	199	Shared Neighborhood Hits	102
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RIMS1_HUMAN
NC score	0.180852 (rank : 166)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	453	Target Neighborhood Hits	437	Shared Neighborhood Hits	147
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

NOS1_MOUSE
NC score	0.179377 (rank : 167)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	453	Target Neighborhood Hits	155	Shared Neighborhood Hits	111
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SHAN2_HUMAN
NC score	0.175476 (rank : 168)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	453	Target Neighborhood Hits	346	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

APXL_HUMAN
NC score	0.175315 (rank : 169)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	453	Target Neighborhood Hits	553	Shared Neighborhood Hits	128
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

PRAX_HUMAN
NC score	0.174234 (rank : 170)	θ value	0.000786445 (rank : 99)
Query Neighborhood Hits	453	Target Neighborhood Hits	215	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

SYNP2_HUMAN
NC score	0.170449 (rank : 171)	θ value	1.06291 (rank : 234)
Query Neighborhood Hits	453	Target Neighborhood Hits	323	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

CAR10_HUMAN
NC score	0.168677 (rank : 172)	θ value	0.000270298 (rank : 90)
Query Neighborhood Hits	453	Target Neighborhood Hits	569	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

PDLI3_MOUSE
NC score	0.168407 (rank : 173)	θ value	0.47712 (rank : 204)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	98
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

RIMS2_MOUSE
NC score	0.166738 (rank : 174)	θ value	0.279714 (rank : 189)
Query Neighborhood Hits	453	Target Neighborhood Hits	376	Shared Neighborhood Hits	110
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.166216 (rank : 175)	θ value	0.279714 (rank : 188)
Query Neighborhood Hits	453	Target Neighborhood Hits	342	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

PDLI4_HUMAN
NC score	0.160367 (rank : 176)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	106
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

SHAN2_MOUSE
NC score	0.155779 (rank : 177)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	453	Target Neighborhood Hits	446	Shared Neighborhood Hits	154
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

PDLI1_HUMAN
NC score	0.153195 (rank : 178)	θ value	6.88961 (rank : 412)
Query Neighborhood Hits	453	Target Neighborhood Hits	242	Shared Neighborhood Hits	95
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
NC score	0.147296 (rank : 179)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	453	Target Neighborhood Hits	213	Shared Neighborhood Hits	93
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

CSKP_HUMAN
NC score	0.146041 (rank : 180)	θ value	0.000121331 (rank : 84)
Query Neighborhood Hits	453	Target Neighborhood Hits	1022	Shared Neighborhood Hits	123
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

GIPC1_MOUSE
NC score	0.144634 (rank : 181)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	453	Target Neighborhood Hits	92	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

LDB3_MOUSE
NC score	0.143991 (rank : 182)	θ value	2.36792 (rank : 279)
Query Neighborhood Hits	453	Target Neighborhood Hits	510	Shared Neighborhood Hits	148
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.143041 (rank : 183)	θ value	2.36792 (rank : 278)
Query Neighborhood Hits	453	Target Neighborhood Hits	497	Shared Neighborhood Hits	140
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDLI5_HUMAN
NC score	0.142209 (rank : 184)	θ value	0.62314 (rank : 210)
Query Neighborhood Hits	453	Target Neighborhood Hits	322	Shared Neighborhood Hits	117
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

GIPC1_HUMAN
NC score	0.138846 (rank : 185)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	453	Target Neighborhood Hits	91	Shared Neighborhood Hits	78
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

PDLI5_MOUSE
NC score	0.135720 (rank : 186)	θ value	0.62314 (rank : 211)
Query Neighborhood Hits	453	Target Neighborhood Hits	287	Shared Neighborhood Hits	113
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

CSKP_MOUSE
NC score	0.134598 (rank : 187)	θ value	0.163984 (rank : 170)
Query Neighborhood Hits	453	Target Neighborhood Hits	1027	Shared Neighborhood Hits	124
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

PDLI7_HUMAN
NC score	0.128654 (rank : 188)	θ value	8.99809 (rank : 441)
Query Neighborhood Hits	453	Target Neighborhood Hits	547	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PTN4_HUMAN
NC score	0.127382 (rank : 189)	θ value	0.21417 (rank : 182)
Query Neighborhood Hits	453	Target Neighborhood Hits	303	Shared Neighborhood Hits	123
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SHAN1_HUMAN
NC score	0.126097 (rank : 190)	θ value	5.27518 (rank : 378)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	201
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

LMO7_HUMAN
NC score	0.120077 (rank : 191)	θ value	3.0926 (rank : 299)
Query Neighborhood Hits	453	Target Neighborhood Hits	507	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

PDZD8_HUMAN
NC score	0.117052 (rank : 192)	θ value	1.81305 (rank : 262)
Query Neighborhood Hits	453	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PDZD6_HUMAN
NC score	0.114303 (rank : 193)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	453	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PTN3_HUMAN
NC score	0.112764 (rank : 194)	θ value	5.27518 (rank : 376)
Query Neighborhood Hits	453	Target Neighborhood Hits	258	Shared Neighborhood Hits	112
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

GIPC2_HUMAN
NC score	0.107468 (rank : 195)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	453	Target Neighborhood Hits	93	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

HTRA3_MOUSE
NC score	0.104663 (rank : 196)	θ value	1.06291 (rank : 229)
Query Neighborhood Hits	453	Target Neighborhood Hits	156	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PDLI7_MOUSE
NC score	0.103975 (rank : 197)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	453	Target Neighborhood Hits	279	Shared Neighborhood Hits	104
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SRRM1_HUMAN
NC score	0.098461 (rank : 198)	θ value	0.21417 (rank : 184)
Query Neighborhood Hits	453	Target Neighborhood Hits	690	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

HTRA3_HUMAN
NC score	0.097173 (rank : 199)	θ value	0.21417 (rank : 179)
Query Neighborhood Hits	453	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

TXND2_HUMAN
NC score	0.092797 (rank : 200)	θ value	4.1701e-05 (rank : 74)
Query Neighborhood Hits	453	Target Neighborhood Hits	793	Shared Neighborhood Hits	99
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

MUC7_HUMAN
NC score	0.091042 (rank : 201)	θ value	0.00134147 (rank : 102)
Query Neighborhood Hits	453	Target Neighborhood Hits	538	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SRRM1_MOUSE
NC score	0.089153 (rank : 202)	θ value	1.38821 (rank : 246)
Query Neighborhood Hits	453	Target Neighborhood Hits	966	Shared Neighborhood Hits	126
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

MDC1_MOUSE
NC score	0.084504 (rank : 203)	θ value	0.0148317 (rank : 130)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	127
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

TIAM1_HUMAN
NC score	0.079851 (rank : 204)	θ value	0.813845 (rank : 223)
Query Neighborhood Hits	453	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

RGS3_MOUSE
NC score	0.075381 (rank : 205)	θ value	2.36792 (rank : 285)
Query Neighborhood Hits	453	Target Neighborhood Hits	1621	Shared Neighborhood Hits	199
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CJ078_MOUSE
NC score	0.073220 (rank : 206)	θ value	0.21417 (rank : 178)
Query Neighborhood Hits	453	Target Neighborhood Hits	559	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CACB1_MOUSE
NC score	0.073086 (rank : 207)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	453	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R3Z5, O88517, Q7TPF2, Q8R3Z6, Q9EPT9	Gene names	Cacnb1, Cacnlb1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

ARI1A_HUMAN
NC score	0.072870 (rank : 208)	θ value	0.000786445 (rank : 95)
Query Neighborhood Hits	453	Target Neighborhood Hits	787	Shared Neighborhood Hits	101
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

CNKR2_MOUSE
NC score	0.072789 (rank : 209)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.072683 (rank : 210)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	453	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

NACAM_MOUSE
NC score	0.070856 (rank : 211)	θ value	0.21417 (rank : 181)
Query Neighborhood Hits	453	Target Neighborhood Hits	1866	Shared Neighborhood Hits	164
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

CACB1_HUMAN
NC score	0.069497 (rank : 212)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	453	Target Neighborhood Hits	44	Shared Neighborhood Hits	21
SwissProt Accessions	Q02641, O15331, Q02639, Q02640, Q9C085	Gene names	CACNB1, CACNLB1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1).

MDC1_HUMAN
NC score	0.068443 (rank : 213)	θ value	0.125558 (rank : 167)
Query Neighborhood Hits	453	Target Neighborhood Hits	1446	Shared Neighborhood Hits	136
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CRK_HUMAN
NC score	0.067805 (rank : 214)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	453	Target Neighborhood Hits	308	Shared Neighborhood Hits	36
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.067791 (rank : 215)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	37
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CACB4_HUMAN
NC score	0.067614 (rank : 216)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	453	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CACB3_HUMAN
NC score	0.066826 (rank : 217)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

CACB3_MOUSE
NC score	0.066182 (rank : 218)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	453	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

RGS3_HUMAN
NC score	0.066167 (rank : 219)	θ value	3.0926 (rank : 309)
Query Neighborhood Hits	453	Target Neighborhood Hits	1375	Shared Neighborhood Hits	161
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CACB4_MOUSE
NC score	0.065531 (rank : 220)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	453	Target Neighborhood Hits	42	Shared Neighborhood Hits	19
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

SRRM2_MOUSE
NC score	0.063899 (rank : 221)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	453	Target Neighborhood Hits	1470	Shared Neighborhood Hits	163
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SRRM2_HUMAN
NC score	0.063827 (rank : 222)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	453	Target Neighborhood Hits	1296	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

HTRA1_HUMAN
NC score	0.063266 (rank : 223)	θ value	1.38821 (rank : 243)
Query Neighborhood Hits	453	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

GIPC3_MOUSE
NC score	0.063205 (rank : 224)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	453	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

GRB2_MOUSE
NC score	0.062846 (rank : 225)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GIPC3_HUMAN
NC score	0.062678 (rank : 226)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	453	Target Neighborhood Hits	52	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC2_MOUSE
NC score	0.062388 (rank : 227)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	453	Target Neighborhood Hits	71	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GRB2_HUMAN
NC score	0.062143 (rank : 228)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	453	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

TIAM1_MOUSE
NC score	0.062122 (rank : 229)	θ value	0.813845 (rank : 224)
Query Neighborhood Hits	453	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

HTRA1_MOUSE
NC score	0.061851 (rank : 230)	θ value	1.81305 (rank : 254)
Query Neighborhood Hits	453	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

IWS1_HUMAN
NC score	0.061055 (rank : 231)	θ value	0.0736092 (rank : 149)
Query Neighborhood Hits	453	Target Neighborhood Hits	1241	Shared Neighborhood Hits	106
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

STAM1_MOUSE
NC score	0.060439 (rank : 232)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	38
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PROP_HUMAN
NC score	0.059138 (rank : 233)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	453	Target Neighborhood Hits	126	Shared Neighborhood Hits	9
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

RNF41_MOUSE
NC score	0.059033 (rank : 234)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	453	Target Neighborhood Hits	224	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.058910 (rank : 235)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	453	Target Neighborhood Hits	226	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

ZCPW1_MOUSE
NC score	0.057906 (rank : 236)	θ value	0.0961366 (rank : 165)
Query Neighborhood Hits	453	Target Neighborhood Hits	307	Shared Neighborhood Hits	39
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

TARA_HUMAN
NC score	0.057685 (rank : 237)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	453	Target Neighborhood Hits	1626	Shared Neighborhood Hits	148
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

YLPM1_HUMAN
NC score	0.057601 (rank : 238)	θ value	1.81305 (rank : 269)
Query Neighborhood Hits	453	Target Neighborhood Hits	670	Shared Neighborhood Hits	100
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

PCLO_HUMAN
NC score	0.057325 (rank : 239)	θ value	1.81305 (rank : 261)
Query Neighborhood Hits	453	Target Neighborhood Hits	2046	Shared Neighborhood Hits	185
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SVIL_MOUSE
NC score	0.056987 (rank : 240)	θ value	0.00509761 (rank : 116)
Query Neighborhood Hits	453	Target Neighborhood Hits	439	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

PROP_MOUSE
NC score	0.056498 (rank : 241)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	453	Target Neighborhood Hits	165	Shared Neighborhood Hits	10
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

RBBP6_HUMAN
NC score	0.056286 (rank : 242)	θ value	1.06291 (rank : 232)
Query Neighborhood Hits	453	Target Neighborhood Hits	1135	Shared Neighborhood Hits	94
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

TGON2_HUMAN
NC score	0.055919 (rank : 243)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	453	Target Neighborhood Hits	1037	Shared Neighborhood Hits	112
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

BAG3_MOUSE
NC score	0.055489 (rank : 244)	θ value	1.38821 (rank : 236)
Query Neighborhood Hits	453	Target Neighborhood Hits	513	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PRG4_HUMAN
NC score	0.055026 (rank : 245)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	453	Target Neighborhood Hits	764	Shared Neighborhood Hits	106
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

WASIP_HUMAN
NC score	0.054290 (rank : 246)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	453	Target Neighborhood Hits	458	Shared Neighborhood Hits	84
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

RPB1_MOUSE
NC score	0.053823 (rank : 247)	θ value	1.38821 (rank : 245)
Query Neighborhood Hits	453	Target Neighborhood Hits	363	Shared Neighborhood Hits	63
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

STAM2_MOUSE
NC score	0.053768 (rank : 248)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	453	Target Neighborhood Hits	285	Shared Neighborhood Hits	33
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

LRRC1_HUMAN
NC score	0.053660 (rank : 249)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	453	Target Neighborhood Hits	282	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

LRRC1_MOUSE
NC score	0.053611 (rank : 250)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	453	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

CARD9_HUMAN
NC score	0.052906 (rank : 251)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	453	Target Neighborhood Hits	602	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

IWS1_MOUSE
NC score	0.052674 (rank : 252)	θ value	1.81305 (rank : 256)
Query Neighborhood Hits	453	Target Neighborhood Hits	1258	Shared Neighborhood Hits	105
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

BLNK_MOUSE
NC score	0.052646 (rank : 253)	θ value	0.279714 (rank : 186)
Query Neighborhood Hits	453	Target Neighborhood Hits	296	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

TMM51_MOUSE
NC score	0.052637 (rank : 254)	θ value	4.03905 (rank : 342)
Query Neighborhood Hits	453	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q99LG1, Q3TPZ3	Gene names	Tmem51
Domain Architecture	No domain graphic available
Description	Transmembrane protein 51.

STAM1_HUMAN
NC score	0.052049 (rank : 255)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	453	Target Neighborhood Hits	271	Shared Neighborhood Hits	35
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

RPB1_HUMAN
NC score	0.051614 (rank : 256)	θ value	2.36792 (rank : 286)
Query Neighborhood Hits	453	Target Neighborhood Hits	362	Shared Neighborhood Hits	63
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RBBP6_MOUSE
NC score	0.051585 (rank : 257)	θ value	2.36792 (rank : 284)
Query Neighborhood Hits	453	Target Neighborhood Hits	1014	Shared Neighborhood Hits	90
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

CACB2_HUMAN
NC score	0.051558 (rank : 258)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	453	Target Neighborhood Hits	99	Shared Neighborhood Hits	22
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

CS016_HUMAN
NC score	0.050969 (rank : 259)	θ value	2.36792 (rank : 272)
Query Neighborhood Hits	453	Target Neighborhood Hits	310	Shared Neighborhood Hits	55
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

MAST4_HUMAN
NC score	0.050720 (rank : 260)	θ value	0.163984 (rank : 172)
Query Neighborhood Hits	453	Target Neighborhood Hits	1804	Shared Neighborhood Hits	205
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

YLPM1_MOUSE
NC score	0.050669 (rank : 261)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	453	Target Neighborhood Hits	505	Shared Neighborhood Hits	83
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

NFH_MOUSE
NC score	0.050513 (rank : 262)	θ value	0.125558 (rank : 168)
Query Neighborhood Hits	453	Target Neighborhood Hits	2247	Shared Neighborhood Hits	177
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

BAG3_HUMAN
NC score	0.050124 (rank : 263)	θ value	6.88961 (rank : 391)
Query Neighborhood Hits	453	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

NCOA6_HUMAN
NC score	0.048716 (rank : 264)	θ value	3.0926 (rank : 305)
Query Neighborhood Hits	453	Target Neighborhood Hits	1202	Shared Neighborhood Hits	140
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

CNOT4_MOUSE
NC score	0.048468 (rank : 265)	θ value	0.0736092 (rank : 148)
Query Neighborhood Hits	453	Target Neighborhood Hits	277	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

NPAS4_MOUSE
NC score	0.048282 (rank : 266)	θ value	0.0330416 (rank : 139)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

SFR15_HUMAN
NC score	0.048130 (rank : 267)	θ value	0.21417 (rank : 183)
Query Neighborhood Hits	453	Target Neighborhood Hits	368	Shared Neighborhood Hits	53
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

BCL9_HUMAN
NC score	0.048093 (rank : 268)	θ value	5.27518 (rank : 349)
Query Neighborhood Hits	453	Target Neighborhood Hits	1008	Shared Neighborhood Hits	130
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

AKAP2_MOUSE
NC score	0.048001 (rank : 269)	θ value	1.06291 (rank : 226)
Query Neighborhood Hits	453	Target Neighborhood Hits	385	Shared Neighborhood Hits	35
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

CNOT4_HUMAN
NC score	0.047934 (rank : 270)	θ value	0.0563607 (rank : 143)
Query Neighborhood Hits	453	Target Neighborhood Hits	207	Shared Neighborhood Hits	20
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

OGFR_MOUSE
NC score	0.046438 (rank : 271)	θ value	0.47712 (rank : 203)
Query Neighborhood Hits	453	Target Neighborhood Hits	584	Shared Neighborhood Hits	61
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

ATX2L_HUMAN
NC score	0.045578 (rank : 272)	θ value	8.99809 (rank : 421)
Query Neighborhood Hits	453	Target Neighborhood Hits	443	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

SVIL_HUMAN
NC score	0.045357 (rank : 273)	θ value	0.21417 (rank : 185)
Query Neighborhood Hits	453	Target Neighborhood Hits	232	Shared Neighborhood Hits	42
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

PO121_MOUSE
NC score	0.045308 (rank : 274)	θ value	0.0736092 (rank : 153)
Query Neighborhood Hits	453	Target Neighborhood Hits	345	Shared Neighborhood Hits	47
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

MAP1A_HUMAN
NC score	0.045292 (rank : 275)	θ value	0.813845 (rank : 217)
Query Neighborhood Hits	453	Target Neighborhood Hits	1626	Shared Neighborhood Hits	114
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

PRRT3_HUMAN
NC score	0.045097 (rank : 276)	θ value	0.365318 (rank : 198)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	113
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

BAT2_MOUSE
NC score	0.044847 (rank : 277)	θ value	4.03905 (rank : 318)
Query Neighborhood Hits	453	Target Neighborhood Hits	947	Shared Neighborhood Hits	127
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

NPBL_MOUSE
NC score	0.044664 (rank : 278)	θ value	5.27518 (rank : 374)
Query Neighborhood Hits	453	Target Neighborhood Hits	1041	Shared Neighborhood Hits	94
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

MILK1_HUMAN
NC score	0.044121 (rank : 279)	θ value	0.0330416 (rank : 138)
Query Neighborhood Hits	453	Target Neighborhood Hits	427	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MAST2_HUMAN
NC score	0.043236 (rank : 280)	θ value	1.06291 (rank : 231)
Query Neighborhood Hits	453	Target Neighborhood Hits	1189	Shared Neighborhood Hits	156
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

BCL9_MOUSE
NC score	0.042197 (rank : 281)	θ value	2.36792 (rank : 270)
Query Neighborhood Hits	453	Target Neighborhood Hits	770	Shared Neighborhood Hits	99
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

MAST2_MOUSE
NC score	0.041884 (rank : 282)	θ value	0.47712 (rank : 202)
Query Neighborhood Hits	453	Target Neighborhood Hits	1110	Shared Neighborhood Hits	146
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PRR8_HUMAN
NC score	0.041779 (rank : 283)	θ value	2.36792 (rank : 283)
Query Neighborhood Hits	453	Target Neighborhood Hits	217	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

SNUT3_HUMAN
NC score	0.041192 (rank : 284)	θ value	2.36792 (rank : 288)
Query Neighborhood Hits	453	Target Neighborhood Hits	52	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WVK2, Q15410	Gene names
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 3 (U4/U6.U5 tri-snRNP-associated 27 kDa protein) (27K) (Nucleic acid-binding protein RY-1).

NIPBL_HUMAN
NC score	0.041161 (rank : 285)	θ value	4.03905 (rank : 332)
Query Neighborhood Hits	453	Target Neighborhood Hits	1311	Shared Neighborhood Hits	106
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NFIB_MOUSE
NC score	0.040636 (rank : 286)	θ value	0.163984 (rank : 174)
Query Neighborhood Hits	453	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	P97863, P70252, P70253, P70254, Q9R1G4	Gene names	Nfib
Domain Architecture
Description	Nuclear factor 1 B-type (Nuclear factor 1/B) (NF1-B) (NFI-B) (NF-I/B) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

OGFR_HUMAN
NC score	0.040601 (rank : 287)	θ value	6.88961 (rank : 411)
Query Neighborhood Hits	453	Target Neighborhood Hits	1582	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ALEX_HUMAN
NC score	0.040551 (rank : 288)	θ value	3.0926 (rank : 291)
Query Neighborhood Hits	453	Target Neighborhood Hits	361	Shared Neighborhood Hits	72
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

NFIB_HUMAN
NC score	0.039732 (rank : 289)	θ value	0.365318 (rank : 194)
Query Neighborhood Hits	453	Target Neighborhood Hits	66	Shared Neighborhood Hits	17
SwissProt Accessions	O00712, O00166, Q12858, Q96J45	Gene names	NFIB
Domain Architecture
Description	Nuclear factor 1 B-type (Nuclear factor 1/B) (NF1-B) (NFI-B) (NF-I/B) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

EFS_MOUSE
NC score	0.039323 (rank : 290)	θ value	1.81305 (rank : 251)
Query Neighborhood Hits	453	Target Neighborhood Hits	389	Shared Neighborhood Hits	47
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

AFF1_HUMAN
NC score	0.039050 (rank : 291)	θ value	6.88961 (rank : 388)
Query Neighborhood Hits	453	Target Neighborhood Hits	506	Shared Neighborhood Hits	74
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

MAST3_HUMAN
NC score	0.038690 (rank : 292)	θ value	4.03905 (rank : 328)
Query Neighborhood Hits	453	Target Neighborhood Hits	1128	Shared Neighborhood Hits	160
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

ASPP1_MOUSE
NC score	0.038637 (rank : 293)	θ value	0.62314 (rank : 206)
Query Neighborhood Hits	453	Target Neighborhood Hits	1244	Shared Neighborhood Hits	104
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ANK2_HUMAN
NC score	0.038531 (rank : 294)	θ value	0.813845 (rank : 214)
Query Neighborhood Hits	453	Target Neighborhood Hits	1615	Shared Neighborhood Hits	135
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

TARA_MOUSE
NC score	0.038365 (rank : 295)	θ value	5.27518 (rank : 382)
Query Neighborhood Hits	453	Target Neighborhood Hits	1133	Shared Neighborhood Hits	107
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

NCOA6_MOUSE
NC score	0.038166 (rank : 296)	θ value	4.03905 (rank : 331)
Query Neighborhood Hits	453	Target Neighborhood Hits	1076	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SIN3A_HUMAN
NC score	0.037538 (rank : 297)	θ value	0.0736092 (rank : 155)
Query Neighborhood Hits	453	Target Neighborhood Hits	180	Shared Neighborhood Hits	32
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

MAST1_MOUSE
NC score	0.037240 (rank : 298)	θ value	3.0926 (rank : 303)
Query Neighborhood Hits	453	Target Neighborhood Hits	1123	Shared Neighborhood Hits	139
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

EFHB_MOUSE
NC score	0.037159 (rank : 299)	θ value	0.47712 (rank : 200)
Query Neighborhood Hits	453	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CDU5	Gene names	Efhb
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

GNDS_HUMAN
NC score	0.037009 (rank : 300)	θ value	1.38821 (rank : 241)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	37
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

EVI2B_HUMAN
NC score	0.036563 (rank : 301)	θ value	0.47712 (rank : 201)
Query Neighborhood Hits	453	Target Neighborhood Hits	135	Shared Neighborhood Hits	24
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

SIN3A_MOUSE
NC score	0.036365 (rank : 302)	θ value	0.0961366 (rank : 163)
Query Neighborhood Hits	453	Target Neighborhood Hits	169	Shared Neighborhood Hits	29
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

IDD_MOUSE
NC score	0.036147 (rank : 303)	θ value	0.0961366 (rank : 159)
Query Neighborhood Hits	453	Target Neighborhood Hits	151	Shared Neighborhood Hits	10
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

MAST1_HUMAN
NC score	0.036143 (rank : 304)	θ value	1.81305 (rank : 257)
Query Neighborhood Hits	453	Target Neighborhood Hits	1146	Shared Neighborhood Hits	141
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

EFS_HUMAN
NC score	0.036029 (rank : 305)	θ value	6.88961 (rank : 399)
Query Neighborhood Hits	453	Target Neighborhood Hits	348	Shared Neighborhood Hits	43
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NKTR_MOUSE
NC score	0.035987 (rank : 306)	θ value	0.0736092 (rank : 150)
Query Neighborhood Hits	453	Target Neighborhood Hits	417	Shared Neighborhood Hits	55
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

MLL3_HUMAN
NC score	0.035951 (rank : 307)	θ value	4.03905 (rank : 329)
Query Neighborhood Hits	453	Target Neighborhood Hits	1644	Shared Neighborhood Hits	137
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

K1210_HUMAN
NC score	0.035647 (rank : 308)	θ value	3.0926 (rank : 298)
Query Neighborhood Hits	453	Target Neighborhood Hits	219	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

CENPT_MOUSE
NC score	0.035596 (rank : 309)	θ value	0.279714 (rank : 187)
Query Neighborhood Hits	453	Target Neighborhood Hits	115	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TJM4, Q3TPY6, Q3UPD2, Q8BTH0, Q8BTP2, Q8R5E9	Gene names	Cenpt
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T).

MUC2_HUMAN
NC score	0.035132 (rank : 310)	θ value	0.163984 (rank : 173)
Query Neighborhood Hits	453	Target Neighborhood Hits	906	Shared Neighborhood Hits	83
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

TP53B_MOUSE
NC score	0.034333 (rank : 311)	θ value	5.27518 (rank : 385)
Query Neighborhood Hits	453	Target Neighborhood Hits	644	Shared Neighborhood Hits	74
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ACINU_HUMAN
NC score	0.034063 (rank : 312)	θ value	4.03905 (rank : 316)
Query Neighborhood Hits	453	Target Neighborhood Hits	828	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BLNK_HUMAN
NC score	0.034029 (rank : 313)	θ value	1.81305 (rank : 249)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CB017_HUMAN
NC score	0.032821 (rank : 314)	θ value	0.163984 (rank : 169)
Query Neighborhood Hits	453	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NC44, Q6P1P5, Q9H0K7	Gene names	C2orf17
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf17.

LRC8E_MOUSE
NC score	0.032676 (rank : 315)	θ value	2.36792 (rank : 280)
Query Neighborhood Hits	453	Target Neighborhood Hits	256	Shared Neighborhood Hits	12
SwissProt Accessions	Q66JT1	Gene names	Lrrc8e
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

MAGE1_HUMAN
NC score	0.032599 (rank : 316)	θ value	1.06291 (rank : 230)
Query Neighborhood Hits	453	Target Neighborhood Hits	1389	Shared Neighborhood Hits	131
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

LIMK2_MOUSE
NC score	0.032477 (rank : 317)	θ value	0.0330416 (rank : 137)
Query Neighborhood Hits	453	Target Neighborhood Hits	998	Shared Neighborhood Hits	77
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MED12_HUMAN
NC score	0.032339 (rank : 318)	θ value	0.21417 (rank : 180)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

NKTR_HUMAN
NC score	0.032330 (rank : 319)	θ value	0.0961366 (rank : 162)
Query Neighborhood Hits	453	Target Neighborhood Hits	658	Shared Neighborhood Hits	62
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

BCAR1_HUMAN
NC score	0.031914 (rank : 320)	θ value	6.88961 (rank : 392)
Query Neighborhood Hits	453	Target Neighborhood Hits	554	Shared Neighborhood Hits	73
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HNRL1_MOUSE
NC score	0.031855 (rank : 321)	θ value	1.38821 (rank : 242)
Query Neighborhood Hits	453	Target Neighborhood Hits	200	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

FA47B_HUMAN
NC score	0.031577 (rank : 322)	θ value	5.27518 (rank : 356)
Query Neighborhood Hits	453	Target Neighborhood Hits	431	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

SH3K1_MOUSE
NC score	0.031344 (rank : 323)	θ value	0.365318 (rank : 199)
Query Neighborhood Hits	453	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCOR1_MOUSE
NC score	0.031332 (rank : 324)	θ value	5.27518 (rank : 372)
Query Neighborhood Hits	453	Target Neighborhood Hits	521	Shared Neighborhood Hits	72
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

ACINU_MOUSE
NC score	0.031146 (rank : 325)	θ value	5.27518 (rank : 345)
Query Neighborhood Hits	453	Target Neighborhood Hits	712	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

FIP1_HUMAN
NC score	0.030767 (rank : 326)	θ value	0.813845 (rank : 215)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

DGKK_HUMAN
NC score	0.030707 (rank : 327)	θ value	0.365318 (rank : 191)
Query Neighborhood Hits	453	Target Neighborhood Hits	378	Shared Neighborhood Hits	53
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

MUCDL_MOUSE
NC score	0.030547 (rank : 328)	θ value	0.813845 (rank : 218)
Query Neighborhood Hits	453	Target Neighborhood Hits	461	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

LRC8E_HUMAN
NC score	0.030318 (rank : 329)	θ value	6.88961 (rank : 408)
Query Neighborhood Hits	453	Target Neighborhood Hits	259	Shared Neighborhood Hits	12
SwissProt Accessions	Q6NSJ5, Q2YDY3, Q7L236, Q8N3B0, Q9H5H8	Gene names	LRRC8E
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

ETV5_MOUSE
NC score	0.030151 (rank : 330)	θ value	0.0148317 (rank : 127)
Query Neighborhood Hits	453	Target Neighborhood Hits	328	Shared Neighborhood Hits	35
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

LIMK2_HUMAN
NC score	0.030054 (rank : 331)	θ value	0.0431538 (rank : 142)
Query Neighborhood Hits	453	Target Neighborhood Hits	986	Shared Neighborhood Hits	80
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

NFH_HUMAN
NC score	0.030008 (rank : 332)	θ value	5.27518 (rank : 373)
Query Neighborhood Hits	453	Target Neighborhood Hits	1242	Shared Neighborhood Hits	101
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

GAB1_HUMAN
NC score	0.029940 (rank : 333)	θ value	1.38821 (rank : 239)
Query Neighborhood Hits	453	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CS019_MOUSE
NC score	0.029557 (rank : 334)	θ value	1.38821 (rank : 237)
Query Neighborhood Hits	453	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D7E4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf25 homolog.

CD2AP_MOUSE
NC score	0.028989 (rank : 335)	θ value	8.99809 (rank : 423)
Query Neighborhood Hits	453	Target Neighborhood Hits	336	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

US6NL_HUMAN
NC score	0.028964 (rank : 336)	θ value	0.813845 (rank : 225)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	41
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

RPGF1_HUMAN
NC score	0.028513 (rank : 337)	θ value	0.813845 (rank : 220)
Query Neighborhood Hits	453	Target Neighborhood Hits	262	Shared Neighborhood Hits	25
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

ZC313_HUMAN
NC score	0.028487 (rank : 338)	θ value	4.03905 (rank : 344)
Query Neighborhood Hits	453	Target Neighborhood Hits	772	Shared Neighborhood Hits	59
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

SNUT3_MOUSE
NC score	0.028432 (rank : 339)	θ value	6.88961 (rank : 417)
Query Neighborhood Hits	453	Target Neighborhood Hits	50	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K194, Q8BRA8, Q9CSV0	Gene names
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 3.

LSR_MOUSE
NC score	0.028258 (rank : 340)	θ value	0.62314 (rank : 209)
Query Neighborhood Hits	453	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q99KG5, Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816	Gene names	Lsr, Lisch7
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor precursor (Liver-specific bHLH-Zip transcription factor) (Lipolysis-stimulated receptor) (Liver- specific gene on mouse chromosome 7 protein).

AFF4_MOUSE
NC score	0.028041 (rank : 341)	θ value	6.88961 (rank : 389)
Query Neighborhood Hits	453	Target Neighborhood Hits	581	Shared Neighborhood Hits	70
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

RC3H1_HUMAN
NC score	0.027854 (rank : 342)	θ value	1.81305 (rank : 264)
Query Neighborhood Hits	453	Target Neighborhood Hits	433	Shared Neighborhood Hits	46
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

GAB2_HUMAN
NC score	0.027763 (rank : 343)	θ value	1.38821 (rank : 240)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

BCAR1_MOUSE
NC score	0.027616 (rank : 344)	θ value	6.88961 (rank : 393)
Query Neighborhood Hits	453	Target Neighborhood Hits	438	Shared Neighborhood Hits	63
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HRX_HUMAN
NC score	0.027235 (rank : 345)	θ value	1.81305 (rank : 253)
Query Neighborhood Hits	453	Target Neighborhood Hits	825	Shared Neighborhood Hits	89
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

WWP2_HUMAN
NC score	0.027176 (rank : 346)	θ value	1.38821 (rank : 247)
Query Neighborhood Hits	453	Target Neighborhood Hits	177	Shared Neighborhood Hits	28
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

PTPRN_MOUSE
NC score	0.027105 (rank : 347)	θ value	0.47712 (rank : 205)
Query Neighborhood Hits	453	Target Neighborhood Hits	240	Shared Neighborhood Hits	22
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

GAB2_MOUSE
NC score	0.026866 (rank : 348)	θ value	1.81305 (rank : 252)
Query Neighborhood Hits	453	Target Neighborhood Hits	220	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PKHA2_HUMAN
NC score	0.026764 (rank : 349)	θ value	0.62314 (rank : 212)
Query Neighborhood Hits	453	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

GAS1_HUMAN
NC score	0.026388 (rank : 350)	θ value	3.0926 (rank : 296)
Query Neighborhood Hits	453	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	P54826	Gene names	GAS1
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 1 precursor (GAS-1).

CDN1C_HUMAN
NC score	0.025918 (rank : 351)	θ value	4.03905 (rank : 319)
Query Neighborhood Hits	453	Target Neighborhood Hits	168	Shared Neighborhood Hits	30
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

GIDRP_MOUSE
NC score	0.025567 (rank : 352)	θ value	3.0926 (rank : 297)
Query Neighborhood Hits	453	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

MUCDL_HUMAN
NC score	0.025444 (rank : 353)	θ value	8.99809 (rank : 438)
Query Neighborhood Hits	453	Target Neighborhood Hits	777	Shared Neighborhood Hits	81
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

CMTA1_HUMAN
NC score	0.025370 (rank : 354)	θ value	1.06291 (rank : 227)
Query Neighborhood Hits	453	Target Neighborhood Hits	217	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

LSR_HUMAN
NC score	0.025281 (rank : 355)	θ value	3.0926 (rank : 300)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	Q86X29, O00112, O00426, Q6ZT80, Q9UQL3	Gene names	LSR, LISCH
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor.

EPN1_HUMAN
NC score	0.025043 (rank : 356)	θ value	0.365318 (rank : 192)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

HNRL1_HUMAN
NC score	0.024667 (rank : 357)	θ value	6.88961 (rank : 405)
Query Neighborhood Hits	453	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

NBR1_HUMAN
NC score	0.024658 (rank : 358)	θ value	4.03905 (rank : 330)
Query Neighborhood Hits	453	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

GTSE1_MOUSE
NC score	0.024374 (rank : 359)	θ value	5.27518 (rank : 363)
Query Neighborhood Hits	453	Target Neighborhood Hits	245	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

TAB3_MOUSE
NC score	0.024041 (rank : 360)	θ value	4.03905 (rank : 339)
Query Neighborhood Hits	453	Target Neighborhood Hits	273	Shared Neighborhood Hits	53
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

CD2AP_HUMAN
NC score	0.023881 (rank : 361)	θ value	5.27518 (rank : 352)
Query Neighborhood Hits	453	Target Neighborhood Hits	315	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SC24A_MOUSE
NC score	0.022866 (rank : 362)	θ value	2.36792 (rank : 287)
Query Neighborhood Hits	453	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SSXT_HUMAN
NC score	0.022500 (rank : 363)	θ value	4.03905 (rank : 338)
Query Neighborhood Hits	453	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q15532, Q16404, Q9BXC6	Gene names	SS18, SSXT, SYT
Domain Architecture
Description	SSXT protein (Synovial sarcoma, translocated to X chromosome) (SYT protein).

MAGC1_HUMAN
NC score	0.022415 (rank : 364)	θ value	3.0926 (rank : 302)
Query Neighborhood Hits	453	Target Neighborhood Hits	431	Shared Neighborhood Hits	62
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

RECQ4_MOUSE
NC score	0.022216 (rank : 365)	θ value	0.0736092 (rank : 154)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

ANK1_HUMAN
NC score	0.022038 (rank : 366)	θ value	0.0961366 (rank : 157)
Query Neighborhood Hits	453	Target Neighborhood Hits	416	Shared Neighborhood Hits	28
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

ANK3_HUMAN
NC score	0.021346 (rank : 367)	θ value	0.21417 (rank : 177)
Query Neighborhood Hits	453	Target Neighborhood Hits	853	Shared Neighborhood Hits	58
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

IF4G1_MOUSE
NC score	0.021110 (rank : 368)	θ value	4.03905 (rank : 327)
Query Neighborhood Hits	453	Target Neighborhood Hits	534	Shared Neighborhood Hits	65
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

MYO15_MOUSE
NC score	0.020734 (rank : 369)	θ value	0.0563607 (rank : 144)
Query Neighborhood Hits	453	Target Neighborhood Hits	467	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ANK1_MOUSE
NC score	0.020594 (rank : 370)	θ value	0.21417 (rank : 176)
Query Neighborhood Hits	453	Target Neighborhood Hits	430	Shared Neighborhood Hits	23
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

TRI47_HUMAN
NC score	0.020165 (rank : 371)	θ value	3.0926 (rank : 313)
Query Neighborhood Hits	453	Target Neighborhood Hits	286	Shared Neighborhood Hits	17
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

SFRS4_MOUSE
NC score	0.020030 (rank : 372)	θ value	3.0926 (rank : 310)
Query Neighborhood Hits	453	Target Neighborhood Hits	406	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VE97, Q9JJC3	Gene names	Sfrs4
Domain Architecture
Description	Splicing factor, arginine/serine-rich 4.

RTN1_HUMAN
NC score	0.019686 (rank : 373)	θ value	1.81305 (rank : 266)
Query Neighborhood Hits	453	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

SNIP_HUMAN
NC score	0.018988 (rank : 374)	θ value	4.03905 (rank : 337)
Query Neighborhood Hits	453	Target Neighborhood Hits	313	Shared Neighborhood Hits	30
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

NCOR1_HUMAN
NC score	0.018979 (rank : 375)	θ value	5.27518 (rank : 371)
Query Neighborhood Hits	453	Target Neighborhood Hits	577	Shared Neighborhood Hits	58
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

CAC1G_HUMAN
NC score	0.018911 (rank : 376)	θ value	0.365318 (rank : 190)
Query Neighborhood Hits	453	Target Neighborhood Hits	587	Shared Neighborhood Hits	65
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

DACT1_HUMAN
NC score	0.018679 (rank : 377)	θ value	8.99809 (rank : 426)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

EPN1_MOUSE
NC score	0.018393 (rank : 378)	θ value	6.88961 (rank : 400)
Query Neighborhood Hits	453	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

MKL1_MOUSE
NC score	0.018339 (rank : 379)	θ value	5.27518 (rank : 369)
Query Neighborhood Hits	453	Target Neighborhood Hits	667	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

IF39_MOUSE
NC score	0.018052 (rank : 380)	θ value	4.03905 (rank : 326)
Query Neighborhood Hits	453	Target Neighborhood Hits	206	Shared Neighborhood Hits	25
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

MBD5_HUMAN
NC score	0.017798 (rank : 381)	θ value	5.27518 (rank : 368)
Query Neighborhood Hits	453	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

PHC2_MOUSE
NC score	0.017700 (rank : 382)	θ value	2.36792 (rank : 281)
Query Neighborhood Hits	453	Target Neighborhood Hits	156	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

ICB1_MOUSE
NC score	0.017537 (rank : 383)	θ value	5.27518 (rank : 367)
Query Neighborhood Hits	453	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q91YX0	Gene names	Icb1
Domain Architecture	No domain graphic available
Description	Induced by contact to basement membrane 1 protein homolog (ICB-1 protein).

SSXT_MOUSE
NC score	0.017217 (rank : 384)	θ value	5.27518 (rank : 381)
Query Neighborhood Hits	453	Target Neighborhood Hits	118	Shared Neighborhood Hits	21
SwissProt Accessions	Q62280	Gene names	Ss18, Ssxt, Syt
Domain Architecture
Description	SSXT protein (SYT protein) (Synovial sarcoma-associated Ss18-alpha).

SPEG_MOUSE
NC score	0.017004 (rank : 385)	θ value	8.99809 (rank : 444)
Query Neighborhood Hits	453	Target Neighborhood Hits	1959	Shared Neighborhood Hits	152
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GNAS1_MOUSE
NC score	0.016991 (rank : 386)	θ value	0.813845 (rank : 216)
Query Neighborhood Hits	453	Target Neighborhood Hits	651	Shared Neighborhood Hits	82
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

SOX30_MOUSE
NC score	0.016908 (rank : 387)	θ value	1.06291 (rank : 233)
Query Neighborhood Hits	453	Target Neighborhood Hits	374	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

ANR11_HUMAN
NC score	0.016874 (rank : 388)	θ value	8.99809 (rank : 420)
Query Neighborhood Hits	453	Target Neighborhood Hits	1289	Shared Neighborhood Hits	96
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

FBX46_MOUSE
NC score	0.016695 (rank : 389)	θ value	1.38821 (rank : 238)
Query Neighborhood Hits	453	Target Neighborhood Hits	139	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

DCC_MOUSE
NC score	0.016547 (rank : 390)	θ value	0.62314 (rank : 207)
Query Neighborhood Hits	453	Target Neighborhood Hits	896	Shared Neighborhood Hits	68
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

HRSL5_HUMAN
NC score	0.016125 (rank : 391)	θ value	1.06291 (rank : 228)
Query Neighborhood Hits	453	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q96KN8	Gene names	HRASLS5, HRLP5
Domain Architecture
Description	HRAS-like suppressor 5 (H-rev107-like protein 5).

TRHY_HUMAN
NC score	0.016047 (rank : 392)	θ value	6.88961 (rank : 418)
Query Neighborhood Hits	453	Target Neighborhood Hits	1385	Shared Neighborhood Hits	64
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

KMHN1_MOUSE
NC score	0.015218 (rank : 393)	θ value	2.36792 (rank : 277)
Query Neighborhood Hits	453	Target Neighborhood Hits	949	Shared Neighborhood Hits	36
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

ELOA3_HUMAN
NC score	0.015113 (rank : 394)	θ value	4.03905 (rank : 323)
Query Neighborhood Hits	453	Target Neighborhood Hits	98	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

BANK1_MOUSE
NC score	0.015073 (rank : 395)	θ value	4.03905 (rank : 317)
Query Neighborhood Hits	453	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	Q80VH0, Q3U178, Q8BRV6, Q8BRY8	Gene names	Bank1
Domain Architecture	No domain graphic available
Description	B-cell scaffold protein with ankyrin repeats (Protein AVIEF).

ARMX2_MOUSE
NC score	0.014940 (rank : 396)	θ value	6.88961 (rank : 390)
Query Neighborhood Hits	453	Target Neighborhood Hits	349	Shared Neighborhood Hits	40
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

ARHGA_HUMAN
NC score	0.014328 (rank : 397)	θ value	3.0926 (rank : 292)
Query Neighborhood Hits	453	Target Neighborhood Hits	187	Shared Neighborhood Hits	12
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

STAT6_MOUSE
NC score	0.014304 (rank : 398)	θ value	1.81305 (rank : 268)
Query Neighborhood Hits	453	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	P52633	Gene names	Stat6
Domain Architecture
Description	Signal transducer and transcription activator 6.

TERF2_MOUSE
NC score	0.014199 (rank : 399)	θ value	4.03905 (rank : 340)
Query Neighborhood Hits	453	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	O35144	Gene names	Terf2, Trf2
Domain Architecture
Description	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein).

LYSM2_HUMAN
NC score	0.014193 (rank : 400)	θ value	3.0926 (rank : 301)
Query Neighborhood Hits	453	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IV50, Q5CZ88, Q8WTV3	Gene names	LYSMD2
Domain Architecture	No domain graphic available
Description	LysM and putative peptidoglycan-binding domain-containing protein 2.

NRBF2_HUMAN
NC score	0.013823 (rank : 401)	θ value	3.0926 (rank : 306)
Query Neighborhood Hits	453	Target Neighborhood Hits	122	Shared Neighborhood Hits	8
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

CA106_HUMAN
NC score	0.013646 (rank : 402)	θ value	5.27518 (rank : 351)
Query Neighborhood Hits	453	Target Neighborhood Hits	124	Shared Neighborhood Hits	17
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

FA13C_HUMAN
NC score	0.013611 (rank : 403)	θ value	6.88961 (rank : 401)
Query Neighborhood Hits	453	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NE31, Q99787	Gene names	FAM13C1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

PRP4B_MOUSE
NC score	0.013531 (rank : 404)	θ value	0.0193708 (rank : 134)
Query Neighborhood Hits	453	Target Neighborhood Hits	1040	Shared Neighborhood Hits	49
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

SPEG_HUMAN
NC score	0.013489 (rank : 405)	θ value	1.81305 (rank : 267)
Query Neighborhood Hits	453	Target Neighborhood Hits	1762	Shared Neighborhood Hits	129
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ETV3_HUMAN
NC score	0.013446 (rank : 406)	θ value	4.03905 (rank : 324)
Query Neighborhood Hits	453	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

PO6F2_HUMAN
NC score	0.013061 (rank : 407)	θ value	2.36792 (rank : 282)
Query Neighborhood Hits	453	Target Neighborhood Hits	618	Shared Neighborhood Hits	57
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

GAK2_HUMAN
NC score	0.013033 (rank : 408)	θ value	4.03905 (rank : 325)
Query Neighborhood Hits	453	Target Neighborhood Hits	406	Shared Neighborhood Hits	45
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

CECR2_HUMAN
NC score	0.012609 (rank : 409)	θ value	6.88961 (rank : 395)
Query Neighborhood Hits	453	Target Neighborhood Hits	543	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

RBP56_HUMAN
NC score	0.012577 (rank : 410)	θ value	5.27518 (rank : 377)
Query Neighborhood Hits	453	Target Neighborhood Hits	157	Shared Neighborhood Hits	8
SwissProt Accessions	Q92804, Q92751	Gene names	TAF15, RBP56, TAF2N
Domain Architecture
Description	TATA-binding protein-associated factor 2N (RNA-binding protein 56) (TAFII68) (TAF(II)68).

YETS2_MOUSE
NC score	0.012407 (rank : 411)	θ value	8.99809 (rank : 450)
Query Neighborhood Hits	453	Target Neighborhood Hits	278	Shared Neighborhood Hits	29
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

NOS3_MOUSE
NC score	0.012276 (rank : 412)	θ value	4.03905 (rank : 333)
Query Neighborhood Hits	453	Target Neighborhood Hits	63	Shared Neighborhood Hits	11
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

GAK12_HUMAN
NC score	0.012121 (rank : 413)	θ value	5.27518 (rank : 362)
Query Neighborhood Hits	453	Target Neighborhood Hits	374	Shared Neighborhood Hits	43
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ZGPAT_HUMAN
NC score	0.011799 (rank : 414)	θ value	3.0926 (rank : 315)
Query Neighborhood Hits	453	Target Neighborhood Hits	97	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5A5, Q5JWI9, Q8NC55, Q96JI0, Q96JU4, Q9H401	Gene names	ZGPAT, KIAA1847, ZC3H9, ZC3HDC9
Domain Architecture
Description	Zinc finger CCCH-type with G patch domain protein (Zinc finger CCCH domain-containing protein 9).

EHMT2_MOUSE
NC score	0.011780 (rank : 415)	θ value	4.03905 (rank : 322)
Query Neighborhood Hits	453	Target Neighborhood Hits	750	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

TF2L1_MOUSE
NC score	0.011652 (rank : 416)	θ value	5.27518 (rank : 384)
Query Neighborhood Hits	453	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q3UNW5, Q99PF2	Gene names	Tcfcp2l1, Crtr1
Domain Architecture	No domain graphic available
Description	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1).

CCAR1_MOUSE
NC score	0.011518 (rank : 417)	θ value	8.99809 (rank : 422)
Query Neighborhood Hits	453	Target Neighborhood Hits	414	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

GAK5_HUMAN
NC score	0.011489 (rank : 418)	θ value	8.99809 (rank : 430)
Query Neighborhood Hits	453	Target Neighborhood Hits	429	Shared Neighborhood Hits	47
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

K0100_MOUSE
NC score	0.011456 (rank : 419)	θ value	2.36792 (rank : 276)
Query Neighborhood Hits	453	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SYL3, Q3UE65, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8	Gene names	Kiaa0100
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor.

K1688_MOUSE
NC score	0.011422 (rank : 420)	θ value	8.99809 (rank : 436)
Query Neighborhood Hits	453	Target Neighborhood Hits	188	Shared Neighborhood Hits	24
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

NOS3_HUMAN
NC score	0.011320 (rank : 421)	θ value	6.88961 (rank : 410)
Query Neighborhood Hits	453	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

PER2_MOUSE
NC score	0.011224 (rank : 422)	θ value	5.27518 (rank : 375)
Query Neighborhood Hits	453	Target Neighborhood Hits	325	Shared Neighborhood Hits	26
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

CCAR1_HUMAN
NC score	0.011188 (rank : 423)	θ value	6.88961 (rank : 394)
Query Neighborhood Hits	453	Target Neighborhood Hits	444	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

TMBI1_MOUSE
NC score	0.011058 (rank : 424)	θ value	3.0926 (rank : 312)
Query Neighborhood Hits	453	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJZ3, Q8CH91, Q99KB6	Gene names	Tmbim1, Recs1
Domain Architecture
Description	Transmembrane BAX inhibitor motif-containing protein 1 (RECS1 protein) (Responsive to centrifugal force and shear stress gene 1 protein).

TF2L1_HUMAN
NC score	0.011054 (rank : 425)	θ value	5.27518 (rank : 383)
Query Neighborhood Hits	453	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZI6, Q4ZG43	Gene names	TFCP2L1, CRTR1, LBP9
Domain Architecture	No domain graphic available
Description	Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9).

PRP4B_HUMAN
NC score	0.011005 (rank : 426)	θ value	6.88961 (rank : 414)
Query Neighborhood Hits	453	Target Neighborhood Hits	1030	Shared Neighborhood Hits	50
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

FRK_HUMAN
NC score	0.010981 (rank : 427)	θ value	5.27518 (rank : 359)
Query Neighborhood Hits	453	Target Neighborhood Hits	1058	Shared Neighborhood Hits	57
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HRBL_HUMAN
NC score	0.010901 (rank : 428)	θ value	5.27518 (rank : 366)
Query Neighborhood Hits	453	Target Neighborhood Hits	179	Shared Neighborhood Hits	21
SwissProt Accessions	O95081, O75429, Q96AB9, Q96GL4	Gene names	HRBL, RABR
Domain Architecture
Description	HIV-1 Rev-binding protein-like protein (Rev/Rex activation domain- binding protein related) (RAB-R).

KI13A_HUMAN
NC score	0.010803 (rank : 429)	θ value	0.0148317 (rank : 128)
Query Neighborhood Hits	453	Target Neighborhood Hits	359	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H1H9, Q9H1H8	Gene names	KIF13A, RBKIN
Domain Architecture
Description	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN).

U2AF2_HUMAN
NC score	0.010798 (rank : 430)	θ value	2.36792 (rank : 289)
Query Neighborhood Hits	453	Target Neighborhood Hits	192	Shared Neighborhood Hits	8
SwissProt Accessions	P26368	Gene names	U2AF2, U2AF65
Domain Architecture
Description	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2 snRNP auxiliary factor large subunit) (hU2AF(65)).

U2AF2_MOUSE
NC score	0.010752 (rank : 431)	θ value	2.36792 (rank : 290)
Query Neighborhood Hits	453	Target Neighborhood Hits	192	Shared Neighborhood Hits	8
SwissProt Accessions	P26369	Gene names	U2af2, U2af65
Domain Architecture
Description	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (U2 snRNP auxiliary factor large subunit).

F103A_HUMAN
NC score	0.010485 (rank : 432)	θ value	8.99809 (rank : 429)
Query Neighborhood Hits	453	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTL3, Q2M1J8	Gene names	FAM103A1, C15orf18
Domain Architecture	No domain graphic available
Description	Protein FAM103A1.

DGCR8_MOUSE
NC score	0.010451 (rank : 433)	θ value	5.27518 (rank : 355)
Query Neighborhood Hits	453	Target Neighborhood Hits	70	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

CO1A1_HUMAN
NC score	0.010248 (rank : 434)	θ value	5.27518 (rank : 353)
Query Neighborhood Hits	453	Target Neighborhood Hits	475	Shared Neighborhood Hits	42
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

SLIK5_MOUSE
NC score	0.010209 (rank : 435)	θ value	5.27518 (rank : 379)
Query Neighborhood Hits	453	Target Neighborhood Hits	301	Shared Neighborhood Hits	12
SwissProt Accessions	Q810B7, Q9CT21	Gene names	Slitrk5
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor.

MORC4_HUMAN
NC score	0.010151 (rank : 436)	θ value	5.27518 (rank : 370)
Query Neighborhood Hits	453	Target Neighborhood Hits	244	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TE76, Q5JUK7, Q96MZ2, Q9HAI7	Gene names	MORC4, ZCWCC2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

SLIK5_HUMAN
NC score	0.010002 (rank : 437)	θ value	6.88961 (rank : 416)
Query Neighborhood Hits	453	Target Neighborhood Hits	302	Shared Neighborhood Hits	16
SwissProt Accessions	O94991	Gene names	SLITRK5, KIAA0918, LRRC11
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

CO2A1_HUMAN
NC score	0.009625 (rank : 438)	θ value	2.36792 (rank : 271)
Query Neighborhood Hits	453	Target Neighborhood Hits	486	Shared Neighborhood Hits	44
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CHD6_HUMAN
NC score	0.009392 (rank : 439)	θ value	4.03905 (rank : 320)
Query Neighborhood Hits	453	Target Neighborhood Hits	342	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

DPYL5_HUMAN
NC score	0.009345 (rank : 440)	θ value	0.62314 (rank : 208)
Query Neighborhood Hits	453	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BPU6, Q8TCL6, Q9NQC4, Q9NRY9	Gene names	DPYSL5, CRMP5, ULIP6
Domain Architecture
Description	Dihydropyrimidinase-related protein 5 (DRP-5) (ULIP6 protein) (Collapsin response mediator protein 5) (CRMP-5) (CRMP3-associated molecule) (CRAM).

YBOX2_HUMAN
NC score	0.009266 (rank : 441)	θ value	5.27518 (rank : 386)
Query Neighborhood Hits	453	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y2T7, Q8N4P0	Gene names	YBX2
Domain Architecture	No domain graphic available
Description	Y-box-binding protein 2 (Germ cell-specific Y-box-binding protein) (Contrin) (MSY2 homolog).

PRDM8_HUMAN
NC score	0.009111 (rank : 442)	θ value	3.0926 (rank : 308)
Query Neighborhood Hits	453	Target Neighborhood Hits	591	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQV8, Q6IQ36	Gene names	PRDM8, PFM5
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 8 (PR domain-containing protein 8).

INP5E_HUMAN
NC score	0.009055 (rank : 443)	θ value	8.99809 (rank : 435)
Query Neighborhood Hits	453	Target Neighborhood Hits	201	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

CHD9_HUMAN
NC score	0.008966 (rank : 444)	θ value	6.88961 (rank : 396)
Query Neighborhood Hits	453	Target Neighborhood Hits	343	Shared Neighborhood Hits	29
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

SRC8_HUMAN
NC score	0.008903 (rank : 445)	θ value	8.99809 (rank : 445)
Query Neighborhood Hits	453	Target Neighborhood Hits	269	Shared Neighborhood Hits	21
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

GP152_MOUSE
NC score	0.008630 (rank : 446)	θ value	2.36792 (rank : 275)
Query Neighborhood Hits	453	Target Neighborhood Hits	607	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

SOCS6_MOUSE
NC score	0.008545 (rank : 447)	θ value	5.27518 (rank : 380)
Query Neighborhood Hits	453	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

PRDM2_HUMAN
NC score	0.008526 (rank : 448)	θ value	0.813845 (rank : 219)
Query Neighborhood Hits	453	Target Neighborhood Hits	1135	Shared Neighborhood Hits	75
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

BTBD7_MOUSE
NC score	0.008348 (rank : 449)	θ value	5.27518 (rank : 350)
Query Neighborhood Hits	453	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

CD2L5_MOUSE
NC score	0.008292 (rank : 450)	θ value	0.00175202 (rank : 105)
Query Neighborhood Hits	453	Target Neighborhood Hits	1011	Shared Neighborhood Hits	49
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

REPS2_MOUSE
NC score	0.008201 (rank : 451)	θ value	6.88961 (rank : 415)
Query Neighborhood Hits	453	Target Neighborhood Hits	102	Shared Neighborhood Hits	14
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

G3BP_MOUSE
NC score	0.007815 (rank : 452)	θ value	6.88961 (rank : 403)
Query Neighborhood Hits	453	Target Neighborhood Hits	209	Shared Neighborhood Hits	21
SwissProt Accessions	P97855	Gene names	G3bp, G3bp1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

TUB_HUMAN
NC score	0.007813 (rank : 453)	θ value	4.03905 (rank : 343)
Query Neighborhood Hits	453	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	P50607, O00293	Gene names	TUB
Domain Architecture
Description	Tubby protein homolog.

GTF2I_HUMAN
NC score	0.007779 (rank : 454)	θ value	8.99809 (rank : 433)
Query Neighborhood Hits	453	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

DYHC_MOUSE
NC score	0.007703 (rank : 455)	θ value	6.88961 (rank : 398)
Query Neighborhood Hits	453	Target Neighborhood Hits	729	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_HUMAN
NC score	0.007615 (rank : 456)	θ value	6.88961 (rank : 397)
Query Neighborhood Hits	453	Target Neighborhood Hits	733	Shared Neighborhood Hits	21
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

MYO1E_HUMAN
NC score	0.007593 (rank : 457)	θ value	8.99809 (rank : 439)
Query Neighborhood Hits	453	Target Neighborhood Hits	293	Shared Neighborhood Hits	29
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MGA_HUMAN
NC score	0.007524 (rank : 458)	θ value	3.0926 (rank : 304)
Query Neighborhood Hits	453	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O43451	Gene names	MGAM, MGA, MGAML
Domain Architecture
Description	Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha- glucosidase)].

ZEP2_HUMAN
NC score	0.006895 (rank : 459)	θ value	6.88961 (rank : 419)
Query Neighborhood Hits	453	Target Neighborhood Hits	937	Shared Neighborhood Hits	61
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

FUSIP_HUMAN
NC score	0.006718 (rank : 460)	θ value	5.27518 (rank : 360)
Query Neighborhood Hits	453	Target Neighborhood Hits	230	Shared Neighborhood Hits	15
SwissProt Accessions	O75494, O60572, Q96G09, Q96P17	Gene names	FUSIP1, TASR
Domain Architecture
Description	FUS-interacting serine-arginine-rich protein 1 (TLS-associated protein with Ser-Arg repeats) (TLS-associated protein with SR repeats) (TASR) (TLS-associated serine-arginine protein) (TLS-associated SR protein) (40 kDa SR-repressor protein) (SRrp40) (Splicing factor SRp38).

FUSIP_MOUSE
NC score	0.006718 (rank : 461)	θ value	5.27518 (rank : 361)
Query Neighborhood Hits	453	Target Neighborhood Hits	230	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0U0, O70307, O88468, Q3TGW7, Q8CFZ1, Q9R0T9	Gene names	Fusip1, Nssr
Domain Architecture
Description	FUS-interacting serine-arginine-rich protein 1 (TLS-associated protein with Ser-Arg repeats) (TLS-associated protein with SR repeats) (TASR) (TLS-associated serine-arginine protein) (TLS-associated SR protein) (Neural-specific SR protein) (Neural-salient serine/arginine-rich protein).

SCN4A_HUMAN
NC score	0.006585 (rank : 462)	θ value	0.813845 (rank : 221)
Query Neighborhood Hits	453	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

DEN2C_MOUSE
NC score	0.006481 (rank : 463)	θ value	3.0926 (rank : 294)
Query Neighborhood Hits	453	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

ZN409_HUMAN
NC score	0.006133 (rank : 464)	θ value	8.99809 (rank : 452)
Query Neighborhood Hits	453	Target Neighborhood Hits	842	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

LBR_HUMAN
NC score	0.005776 (rank : 465)	θ value	6.88961 (rank : 407)
Query Neighborhood Hits	453	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q14739, Q14740, Q53GU7, Q59FE6	Gene names	LBR
Domain Architecture
Description	Lamin-B receptor (Integral nuclear envelope inner membrane protein) (LMN2R).

ZEP2_MOUSE
NC score	0.005760 (rank : 466)	θ value	1.06291 (rank : 235)
Query Neighborhood Hits	453	Target Neighborhood Hits	964	Shared Neighborhood Hits	64
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

HIPK1_HUMAN
NC score	0.005497 (rank : 467)	θ value	5.27518 (rank : 364)
Query Neighborhood Hits	453	Target Neighborhood Hits	843	Shared Neighborhood Hits	31
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.005447 (rank : 468)	θ value	6.88961 (rank : 404)
Query Neighborhood Hits	453	Target Neighborhood Hits	838	Shared Neighborhood Hits	30
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

DDX46_MOUSE
NC score	0.005358 (rank : 469)	θ value	4.03905 (rank : 321)
Query Neighborhood Hits	453	Target Neighborhood Hits	358	Shared Neighborhood Hits	26
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

ESCO1_MOUSE
NC score	0.005342 (rank : 470)	θ value	8.99809 (rank : 428)
Query Neighborhood Hits	453	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q69Z69, Q8BQI2, Q8BR47, Q922F5	Gene names	Esco1, Kiaa1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1).

NUCL_HUMAN
NC score	0.005178 (rank : 471)	θ value	8.99809 (rank : 440)
Query Neighborhood Hits	453	Target Neighborhood Hits	415	Shared Neighborhood Hits	33
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

PI3R4_MOUSE
NC score	0.005127 (rank : 472)	θ value	6.88961 (rank : 413)
Query Neighborhood Hits	453	Target Neighborhood Hits	535	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

SYT6_HUMAN
NC score	0.005012 (rank : 473)	θ value	8.99809 (rank : 448)
Query Neighborhood Hits	453	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SMCA5_MOUSE
NC score	0.004863 (rank : 474)	θ value	3.0926 (rank : 311)
Query Neighborhood Hits	453	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q91ZW3, Q8C791, Q8CA22, Q8VDG1, Q925M9	Gene names	Smarca5, Snf2h
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.1.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h).

CO4A2_MOUSE
NC score	0.004818 (rank : 475)	θ value	5.27518 (rank : 354)
Query Neighborhood Hits	453	Target Neighborhood Hits	492	Shared Neighborhood Hits	41
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

DYR1B_MOUSE
NC score	0.004816 (rank : 476)	θ value	1.81305 (rank : 250)
Query Neighborhood Hits	453	Target Neighborhood Hits	799	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYR1B_HUMAN
NC score	0.004609 (rank : 477)	θ value	2.36792 (rank : 273)
Query Neighborhood Hits	453	Target Neighborhood Hits	831	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

LOXL1_HUMAN
NC score	0.004551 (rank : 478)	θ value	8.99809 (rank : 437)
Query Neighborhood Hits	453	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

KAP1_HUMAN
NC score	0.004216 (rank : 479)	θ value	6.88961 (rank : 406)
Query Neighborhood Hits	453	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

DACH2_HUMAN
NC score	0.003573 (rank : 480)	θ value	8.99809 (rank : 425)
Query Neighborhood Hits	453	Target Neighborhood Hits	122	Shared Neighborhood Hits	4
SwissProt Accessions	Q96NX9, Q8NAY3, Q8ND17, Q96N55	Gene names	DACH2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

FIGLA_HUMAN
NC score	0.003527 (rank : 481)	θ value	6.88961 (rank : 402)
Query Neighborhood Hits	453	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

SIG10_HUMAN
NC score	0.003292 (rank : 482)	θ value	8.99809 (rank : 443)
Query Neighborhood Hits	453	Target Neighborhood Hits	363	Shared Neighborhood Hits	23
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

TLE1_HUMAN
NC score	0.003054 (rank : 483)	θ value	4.03905 (rank : 341)
Query Neighborhood Hits	453	Target Neighborhood Hits	485	Shared Neighborhood Hits	28
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

FBLN2_MOUSE
NC score	0.001742 (rank : 484)	θ value	5.27518 (rank : 358)
Query Neighborhood Hits	453	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

TBX15_HUMAN
NC score	0.001205 (rank : 485)	θ value	8.99809 (rank : 449)
Query Neighborhood Hits	453	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q96SF7, Q5T9S7	Gene names	TBX15, TBX14
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX15 (T-box protein 15).

KLF5_HUMAN
NC score	0.001121 (rank : 486)	θ value	0.163984 (rank : 171)
Query Neighborhood Hits	453	Target Neighborhood Hits	727	Shared Neighborhood Hits	22
SwissProt Accessions	Q13887, Q9UHP8	Gene names	KLF5, BTEB2, CKLF, IKLF
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Colon krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2) (GC box-binding protein 2).

ZBT38_HUMAN
NC score	0.001071 (rank : 487)	θ value	0.0961366 (rank : 164)
Query Neighborhood Hits	453	Target Neighborhood Hits	885	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NAP3	Gene names	ZBTB38
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 38.

KLF5_MOUSE
NC score	0.001024 (rank : 488)	θ value	0.365318 (rank : 193)
Query Neighborhood Hits	453	Target Neighborhood Hits	726	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z0Z7, Q9JMI2	Gene names	Klf5, Bteb2, Iklf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2).

SALL3_HUMAN
NC score	0.000569 (rank : 489)	θ value	8.99809 (rank : 442)
Query Neighborhood Hits	453	Target Neighborhood Hits	1066	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

DDX20_HUMAN
NC score	0.000294 (rank : 490)	θ value	8.99809 (rank : 427)
Query Neighborhood Hits	453	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DSC3_HUMAN
NC score	-0.000718 (rank : 491)	θ value	3.0926 (rank : 295)
Query Neighborhood Hits	453	Target Neighborhood Hits	150	Shared Neighborhood Hits	5
SwissProt Accessions	Q14574, Q14200, Q9HAZ9	Gene names	DSC3, DSC4
Domain Architecture
Description	Desmocollin-3 precursor (Desmocollin-4) (HT-CP).

GLI2_HUMAN
NC score	-0.000818 (rank : 492)	θ value	2.36792 (rank : 274)
Query Neighborhood Hits	453	Target Neighborhood Hits	971	Shared Neighborhood Hits	51
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

HXD4_HUMAN
NC score	-0.000828 (rank : 493)	θ value	1.81305 (rank : 255)
Query Neighborhood Hits	453	Target Neighborhood Hits	337	Shared Neighborhood Hits	8
SwissProt Accessions	P09016, Q96AU0	Gene names	HOXD4, HOX4B
Domain Architecture
Description	Homeobox protein Hox-D4 (Hox-4B) (Hox-5.1) (HHO.C13).

IKAR_HUMAN
NC score	-0.000882 (rank : 494)	θ value	0.125558 (rank : 166)
Query Neighborhood Hits	453	Target Neighborhood Hits	726	Shared Neighborhood Hits	22
SwissProt Accessions	Q13422, O00598, Q8WVA3	Gene names	IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Domain Architecture	No domain graphic available
Description	DNA-binding protein Ikaros (IKAROS family zinc finger protein 1) (Lymphoid transcription factor LyF-1).

HXD4_MOUSE
NC score	-0.001359 (rank : 495)	θ value	8.99809 (rank : 434)
Query Neighborhood Hits	453	Target Neighborhood Hits	339	Shared Neighborhood Hits	13
SwissProt Accessions	P10628, P97451, Q3UXL6	Gene names	Hoxd4, Hox-4.2, Hoxd-4
Domain Architecture
Description	Homeobox protein Hox-D4 (Hox-4.2) (Hox-5.1).

AATK_HUMAN
NC score	-0.001374 (rank : 496)	θ value	6.88961 (rank : 387)
Query Neighborhood Hits	453	Target Neighborhood Hits	1243	Shared Neighborhood Hits	67
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ZXDB_HUMAN
NC score	-0.001525 (rank : 497)	θ value	0.0736092 (rank : 156)
Query Neighborhood Hits	453	Target Neighborhood Hits	753	Shared Neighborhood Hits	26
SwissProt Accessions	P98169, Q9UBB3	Gene names	ZXDB
Domain Architecture	No domain graphic available
Description	Zinc finger X-linked protein ZXDB.

FAK1_MOUSE
NC score	-0.002147 (rank : 498)	θ value	5.27518 (rank : 357)
Query Neighborhood Hits	453	Target Neighborhood Hits	850	Shared Neighborhood Hits	25
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ZBT46_HUMAN
NC score	-0.003528 (rank : 499)	θ value	3.0926 (rank : 314)
Query Neighborhood Hits	453	Target Neighborhood Hits	813	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UZ6, Q5JWJ3, Q9BQK3, Q9H3Z8, Q9H3Z9	Gene names	ZBTB46, BTBD4, ZNF340
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 46 (BTB/POZ domain- containing protein 4) (Zinc finger protein 340).

BCL6_HUMAN
NC score	-0.003530 (rank : 500)	θ value	3.0926 (rank : 293)
Query Neighborhood Hits	453	Target Neighborhood Hits	922	Shared Neighborhood Hits	37
SwissProt Accessions	P41182	Gene names	BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Domain Architecture
Description	B-cell lymphoma 6 protein (BCL-6) (Zinc finger protein 51) (LAZ-3 protein) (BCL-5) (Zinc finger and BTB domain-containing protein 27).

ZN462_HUMAN
NC score	-0.004477 (rank : 501)	θ value	8.99809 (rank : 453)
Query Neighborhood Hits	453	Target Neighborhood Hits	740	Shared Neighborhood Hits	18
SwissProt Accessions	Q96JM2, Q8N408	Gene names	ZNF462, KIAA1803
Domain Architecture	No domain graphic available
Description	Zinc finger protein 462.

MTR1L_HUMAN
NC score	-0.005280 (rank : 502)	θ value	6.88961 (rank : 409)
Query Neighborhood Hits	453	Target Neighborhood Hits	1180	Shared Neighborhood Hits	49
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

HKR3_HUMAN
NC score	-0.005560 (rank : 503)	θ value	5.27518 (rank : 365)
Query Neighborhood Hits	453	Target Neighborhood Hits	839	Shared Neighborhood Hits	25
SwissProt Accessions	P10074	Gene names	HKR3
Domain Architecture
Description	Krueppel-related zinc finger protein 3 (Protein HKR3).

CELR3_MOUSE
NC score	-0.005742 (rank : 504)	θ value	8.99809 (rank : 424)
Query Neighborhood Hits	453	Target Neighborhood Hits	687	Shared Neighborhood Hits	16
SwissProt Accessions	Q91ZI0, Q9ESD0	Gene names	Celsr3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor.

ZKSC1_MOUSE
NC score	-0.006285 (rank : 505)	θ value	8.99809 (rank : 451)
Query Neighborhood Hits	453	Target Neighborhood Hits	755	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BGS3, Q7TS88, Q8BJ55, Q9CRN6	Gene names	Zkscan1
Domain Architecture	No domain graphic available
Description	Zinc finger with KRAB and SCAN domain-containing protein 1.