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Network neighborhood for query Sequence : GAB2_HUMAN

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GAB2_HUMAN
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GAB2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	188	Target Neighborhood Hits	188	Shared Neighborhood Hits	188
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
θ value	0 (rank : 2)	NC score	0.968699 (rank : 2)
Query Neighborhood Hits	188	Target Neighborhood Hits	220	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAB1_HUMAN
θ value	1.09934e-114 (rank : 3)	NC score	0.878932 (rank : 4)
Query Neighborhood Hits	188	Target Neighborhood Hits	279	Shared Neighborhood Hits	78
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
θ value	1.21547e-113 (rank : 4)	NC score	0.884019 (rank : 3)
Query Neighborhood Hits	188	Target Neighborhood Hits	233	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

MYO10_HUMAN
θ value	1.53129e-07 (rank : 5)	NC score	0.120659 (rank : 48)
Query Neighborhood Hits	188	Target Neighborhood Hits	920	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PKHA2_MOUSE
θ value	7.59969e-07 (rank : 6)	NC score	0.376285 (rank : 8)
Query Neighborhood Hits	188	Target Neighborhood Hits	116	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA1_HUMAN
θ value	1.69304e-06 (rank : 7)	NC score	0.389338 (rank : 6)
Query Neighborhood Hits	188	Target Neighborhood Hits	127	Shared Neighborhood Hits	61
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	1.69304e-06 (rank : 8)	NC score	0.401204 (rank : 5)
Query Neighborhood Hits	188	Target Neighborhood Hits	120	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	1.69304e-06 (rank : 9)	NC score	0.378656 (rank : 7)
Query Neighborhood Hits	188	Target Neighborhood Hits	119	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

IRS1_HUMAN
θ value	2.88788e-06 (rank : 10)	NC score	0.246857 (rank : 11)
Query Neighborhood Hits	188	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

IRS1_MOUSE
θ value	1.87187e-05 (rank : 11)	NC score	0.237965 (rank : 16)
Query Neighborhood Hits	188	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

DOC10_HUMAN
θ value	2.44474e-05 (rank : 12)	NC score	0.153334 (rank : 31)
Query Neighborhood Hits	188	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

SRRM2_MOUSE
θ value	3.19293e-05 (rank : 13)	NC score	0.148241 (rank : 34)
Query Neighborhood Hits	188	Target Neighborhood Hits	1470	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PLEK_MOUSE
θ value	4.1701e-05 (rank : 14)	NC score	0.306591 (rank : 10)
Query Neighborhood Hits	188	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PHLB1_MOUSE
θ value	5.44631e-05 (rank : 15)	NC score	0.231069 (rank : 17)
Query Neighborhood Hits	188	Target Neighborhood Hits	678	Shared Neighborhood Hits	70
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLEK_HUMAN
θ value	5.44631e-05 (rank : 16)	NC score	0.311476 (rank : 9)
Query Neighborhood Hits	188	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CNKR2_HUMAN
θ value	0.000121331 (rank : 17)	NC score	0.240710 (rank : 15)
Query Neighborhood Hits	188	Target Neighborhood Hits	197	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.000121331 (rank : 18)	NC score	0.240909 (rank : 14)
Query Neighborhood Hits	188	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PHLB2_MOUSE
θ value	0.000121331 (rank : 19)	NC score	0.178916 (rank : 23)
Query Neighborhood Hits	188	Target Neighborhood Hits	1016	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_HUMAN
θ value	0.000158464 (rank : 20)	NC score	0.182650 (rank : 22)
Query Neighborhood Hits	188	Target Neighborhood Hits	964	Shared Neighborhood Hits	56
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

DAPP1_MOUSE
θ value	0.000270298 (rank : 21)	NC score	0.245529 (rank : 12)
Query Neighborhood Hits	188	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
θ value	0.00035302 (rank : 22)	NC score	0.242555 (rank : 13)
Query Neighborhood Hits	188	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CEND2_HUMAN
θ value	0.000461057 (rank : 23)	NC score	0.132539 (rank : 42)
Query Neighborhood Hits	188	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

SRRM2_HUMAN
θ value	0.000602161 (rank : 24)	NC score	0.156225 (rank : 30)
Query Neighborhood Hits	188	Target Neighborhood Hits	1296	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PHLB1_HUMAN
θ value	0.00102713 (rank : 25)	NC score	0.201659 (rank : 19)
Query Neighborhood Hits	188	Target Neighborhood Hits	1038	Shared Neighborhood Hits	84
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CEND1_HUMAN
θ value	0.00134147 (rank : 26)	NC score	0.141663 (rank : 35)
Query Neighborhood Hits	188	Target Neighborhood Hits	284	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RPB1_HUMAN
θ value	0.00134147 (rank : 27)	NC score	0.139132 (rank : 37)
Query Neighborhood Hits	188	Target Neighborhood Hits	362	Shared Neighborhood Hits	34
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	0.00134147 (rank : 28)	NC score	0.139502 (rank : 36)
Query Neighborhood Hits	188	Target Neighborhood Hits	363	Shared Neighborhood Hits	35
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

MRIP_HUMAN
θ value	0.00298849 (rank : 29)	NC score	0.169535 (rank : 26)
Query Neighborhood Hits	188	Target Neighborhood Hits	578	Shared Neighborhood Hits	54
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

MRIP_MOUSE
θ value	0.00390308 (rank : 30)	NC score	0.160852 (rank : 28)
Query Neighborhood Hits	188	Target Neighborhood Hits	569	Shared Neighborhood Hits	53
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RASA1_HUMAN
θ value	0.00665767 (rank : 31)	NC score	0.136925 (rank : 39)
Query Neighborhood Hits	188	Target Neighborhood Hits	258	Shared Neighborhood Hits	40
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASA2_MOUSE
θ value	0.00665767 (rank : 32)	NC score	0.132970 (rank : 41)
Query Neighborhood Hits	188	Target Neighborhood Hits	159	Shared Neighborhood Hits	31
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PPRB_MOUSE
θ value	0.00869519 (rank : 33)	NC score	0.074514 (rank : 78)
Query Neighborhood Hits	188	Target Neighborhood Hits	354	Shared Neighborhood Hits	31
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

TBCD2_HUMAN
θ value	0.00869519 (rank : 34)	NC score	0.120088 (rank : 49)
Query Neighborhood Hits	188	Target Neighborhood Hits	419	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

DOCK9_HUMAN
θ value	0.0148317 (rank : 35)	NC score	0.116513 (rank : 52)
Query Neighborhood Hits	188	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

TARA_MOUSE
θ value	0.0148317 (rank : 36)	NC score	0.152091 (rank : 32)
Query Neighborhood Hits	188	Target Neighborhood Hits	1133	Shared Neighborhood Hits	83
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MAGC1_HUMAN
θ value	0.0193708 (rank : 37)	NC score	0.060849 (rank : 100)
Query Neighborhood Hits	188	Target Neighborhood Hits	431	Shared Neighborhood Hits	36
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

CEND1_MOUSE
θ value	0.0252991 (rank : 38)	NC score	0.111959 (rank : 54)
Query Neighborhood Hits	188	Target Neighborhood Hits	260	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

PYGO1_HUMAN
θ value	0.0252991 (rank : 39)	NC score	0.105080 (rank : 57)
Query Neighborhood Hits	188	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y3Y4	Gene names	PYGO1
Domain Architecture
Description	Pygopus homolog 1.

SWP70_HUMAN
θ value	0.0252991 (rank : 40)	NC score	0.129157 (rank : 45)
Query Neighborhood Hits	188	Target Neighborhood Hits	973	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PEX5R_HUMAN
θ value	0.0431538 (rank : 41)	NC score	0.062447 (rank : 94)
Query Neighborhood Hits	188	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

SWP70_MOUSE
θ value	0.0431538 (rank : 42)	NC score	0.130501 (rank : 44)
Query Neighborhood Hits	188	Target Neighborhood Hits	1097	Shared Neighborhood Hits	68
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

DOCK9_MOUSE
θ value	0.0563607 (rank : 43)	NC score	0.128184 (rank : 46)
Query Neighborhood Hits	188	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

MTMRD_HUMAN
θ value	0.0563607 (rank : 44)	NC score	0.108575 (rank : 55)
Query Neighborhood Hits	188	Target Neighborhood Hits	135	Shared Neighborhood Hits	42
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PYGO1_MOUSE
θ value	0.0563607 (rank : 45)	NC score	0.080479 (rank : 66)
Query Neighborhood Hits	188	Target Neighborhood Hits	69	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.

MTMR5_HUMAN
θ value	0.0961366 (rank : 46)	NC score	0.118587 (rank : 50)
Query Neighborhood Hits	188	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

CNKR1_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.217854 (rank : 18)
Query Neighborhood Hits	188	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

RASA2_HUMAN
θ value	0.125558 (rank : 48)	NC score	0.112066 (rank : 53)
Query Neighborhood Hits	188	Target Neighborhood Hits	157	Shared Neighborhood Hits	29
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

K0460_HUMAN
θ value	0.163984 (rank : 49)	NC score	0.061143 (rank : 98)
Query Neighborhood Hits	188	Target Neighborhood Hits	357	Shared Neighborhood Hits	26
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

CS007_MOUSE
θ value	0.21417 (rank : 50)	NC score	0.064026 (rank : 92)
Query Neighborhood Hits	188	Target Neighborhood Hits	464	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

PER3_HUMAN
θ value	0.21417 (rank : 51)	NC score	0.055781 (rank : 109)
Query Neighborhood Hits	188	Target Neighborhood Hits	479	Shared Neighborhood Hits	40
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

SGIP1_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.073659 (rank : 82)
Query Neighborhood Hits	188	Target Neighborhood Hits	198	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

DCP1A_MOUSE
θ value	0.279714 (rank : 53)	NC score	0.046717 (rank : 126)
Query Neighborhood Hits	188	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YD3, Q6NZE3	Gene names	Dcp1a, Mitc1, Smif
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (MAD homolog 4-interacting transcription coactivator 1) (Smad4-interacting transcriptional co-activator).

MUC15_MOUSE
θ value	0.279714 (rank : 54)	NC score	0.077001 (rank : 73)
Query Neighborhood Hits	188	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C6Z1, Q3UQC4, Q6XYQ9, Q7TMH6, Q8CE82	Gene names	Muc15
Domain Architecture	No domain graphic available
Description	Mucin-15 precursor.

MUC2_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.048528 (rank : 123)
Query Neighborhood Hits	188	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

PDE3A_MOUSE
θ value	0.279714 (rank : 56)	NC score	0.027299 (rank : 149)
Query Neighborhood Hits	188	Target Neighborhood Hits	115	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PKHA5_HUMAN
θ value	0.279714 (rank : 57)	NC score	0.178295 (rank : 24)
Query Neighborhood Hits	188	Target Neighborhood Hits	455	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

WNK4_HUMAN
θ value	0.279714 (rank : 58)	NC score	0.017874 (rank : 175)
Query Neighborhood Hits	188	Target Neighborhood Hits	1043	Shared Neighborhood Hits	31
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

JIP3_HUMAN
θ value	0.365318 (rank : 59)	NC score	0.041354 (rank : 134)
Query Neighborhood Hits	188	Target Neighborhood Hits	1039	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

NCOA6_HUMAN
θ value	0.365318 (rank : 60)	NC score	0.061294 (rank : 97)
Query Neighborhood Hits	188	Target Neighborhood Hits	1202	Shared Neighborhood Hits	75
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

RASL1_MOUSE
θ value	0.365318 (rank : 61)	NC score	0.058031 (rank : 102)
Query Neighborhood Hits	188	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

SHAN1_HUMAN
θ value	0.365318 (rank : 62)	NC score	0.042969 (rank : 132)
Query Neighborhood Hits	188	Target Neighborhood Hits	1041	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PKHA4_HUMAN
θ value	0.47712 (rank : 63)	NC score	0.148895 (rank : 33)
Query Neighborhood Hits	188	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	0.47712 (rank : 64)	NC score	0.156691 (rank : 29)
Query Neighborhood Hits	188	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SP4_MOUSE
θ value	0.47712 (rank : 65)	NC score	0.007395 (rank : 201)
Query Neighborhood Hits	188	Target Neighborhood Hits	759	Shared Neighborhood Hits	11
SwissProt Accessions	Q62445	Gene names	Sp4
Domain Architecture
Description	Transcription factor Sp4.

TARA_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.132184 (rank : 43)
Query Neighborhood Hits	188	Target Neighborhood Hits	1626	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AFF1_HUMAN
θ value	0.62314 (rank : 67)	NC score	0.045976 (rank : 127)
Query Neighborhood Hits	188	Target Neighborhood Hits	506	Shared Neighborhood Hits	31
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

COR2A_MOUSE
θ value	0.62314 (rank : 68)	NC score	0.013364 (rank : 185)
Query Neighborhood Hits	188	Target Neighborhood Hits	204	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0P5, Q3U6H8, Q8BW42	Gene names	Coro2a
Domain Architecture	No domain graphic available
Description	Coronin-2A.

MINT_MOUSE
θ value	0.62314 (rank : 69)	NC score	0.054157 (rank : 113)
Query Neighborhood Hits	188	Target Neighborhood Hits	1514	Shared Neighborhood Hits	61
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NCOR1_MOUSE
θ value	0.62314 (rank : 70)	NC score	0.032714 (rank : 143)
Query Neighborhood Hits	188	Target Neighborhood Hits	521	Shared Neighborhood Hits	29
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

OSBP2_MOUSE
θ value	0.62314 (rank : 71)	NC score	0.091808 (rank : 60)
Query Neighborhood Hits	188	Target Neighborhood Hits	150	Shared Neighborhood Hits	51
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

RAI14_MOUSE
θ value	0.62314 (rank : 72)	NC score	0.016824 (rank : 178)
Query Neighborhood Hits	188	Target Neighborhood Hits	1505	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

BSN_HUMAN
θ value	0.813845 (rank : 73)	NC score	0.054841 (rank : 111)
Query Neighborhood Hits	188	Target Neighborhood Hits	1537	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

OSBL3_MOUSE
θ value	0.813845 (rank : 74)	NC score	0.066021 (rank : 89)
Query Neighborhood Hits	188	Target Neighborhood Hits	86	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBP1_HUMAN
θ value	0.813845 (rank : 75)	NC score	0.094406 (rank : 59)
Query Neighborhood Hits	188	Target Neighborhood Hits	180	Shared Neighborhood Hits	46
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

REXO1_HUMAN
θ value	0.813845 (rank : 76)	NC score	0.048888 (rank : 122)
Query Neighborhood Hits	188	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

SYNJ1_HUMAN
θ value	0.813845 (rank : 77)	NC score	0.045161 (rank : 129)
Query Neighborhood Hits	188	Target Neighborhood Hits	498	Shared Neighborhood Hits	39
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

UBP29_HUMAN
θ value	0.813845 (rank : 78)	NC score	0.031371 (rank : 144)
Query Neighborhood Hits	188	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBJ7	Gene names	USP29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

BMX_HUMAN
θ value	1.06291 (rank : 79)	NC score	0.023069 (rank : 157)
Query Neighborhood Hits	188	Target Neighborhood Hits	942	Shared Neighborhood Hits	39
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CENA2_MOUSE
θ value	1.06291 (rank : 80)	NC score	0.061125 (rank : 99)
Query Neighborhood Hits	188	Target Neighborhood Hits	68	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

IRS2_HUMAN
θ value	1.06291 (rank : 81)	NC score	0.133310 (rank : 40)
Query Neighborhood Hits	188	Target Neighborhood Hits	262	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

MINT_HUMAN
θ value	1.06291 (rank : 82)	NC score	0.047948 (rank : 125)
Query Neighborhood Hits	188	Target Neighborhood Hits	1291	Shared Neighborhood Hits	56
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

OSBL3_HUMAN
θ value	1.06291 (rank : 83)	NC score	0.066043 (rank : 88)
Query Neighborhood Hits	188	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

PKHA6_MOUSE
θ value	1.06291 (rank : 84)	NC score	0.175696 (rank : 25)
Query Neighborhood Hits	188	Target Neighborhood Hits	591	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RAPH1_HUMAN
θ value	1.06291 (rank : 85)	NC score	0.079454 (rank : 70)
Query Neighborhood Hits	188	Target Neighborhood Hits	593	Shared Neighborhood Hits	43
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SETBP_MOUSE
θ value	1.06291 (rank : 86)	NC score	0.071567 (rank : 83)
Query Neighborhood Hits	188	Target Neighborhood Hits	352	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

WNK4_MOUSE
θ value	1.06291 (rank : 87)	NC score	0.014419 (rank : 181)
Query Neighborhood Hits	188	Target Neighborhood Hits	961	Shared Neighborhood Hits	29
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

BRDT_MOUSE
θ value	1.38821 (rank : 88)	NC score	0.023050 (rank : 158)
Query Neighborhood Hits	188	Target Neighborhood Hits	243	Shared Neighborhood Hits	14
SwissProt Accessions	Q91Y44, Q59HJ4	Gene names	Brdt, Fsrg3
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein) (Bromodomain- containing female sterile homeotic-like protein).

CASC5_MOUSE
θ value	1.38821 (rank : 89)	NC score	0.035670 (rank : 140)
Query Neighborhood Hits	188	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

EGFR_HUMAN
θ value	1.38821 (rank : 90)	NC score	0.007622 (rank : 199)
Query Neighborhood Hits	188	Target Neighborhood Hits	939	Shared Neighborhood Hits	16
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

KIFC3_HUMAN
θ value	1.38821 (rank : 91)	NC score	0.016021 (rank : 179)
Query Neighborhood Hits	188	Target Neighborhood Hits	619	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

NCOA3_HUMAN
θ value	1.38821 (rank : 92)	NC score	0.017117 (rank : 177)
Query Neighborhood Hits	188	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

PKHA6_HUMAN
θ value	1.38821 (rank : 93)	NC score	0.166501 (rank : 27)
Query Neighborhood Hits	188	Target Neighborhood Hits	556	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SP4_HUMAN
θ value	1.38821 (rank : 94)	NC score	0.005510 (rank : 204)
Query Neighborhood Hits	188	Target Neighborhood Hits	749	Shared Neighborhood Hits	10
SwissProt Accessions	Q02446, O60402	Gene names	SP4
Domain Architecture
Description	Transcription factor Sp4 (SPR-1).

SRRM1_MOUSE
θ value	1.38821 (rank : 95)	NC score	0.090105 (rank : 61)
Query Neighborhood Hits	188	Target Neighborhood Hits	966	Shared Neighborhood Hits	62
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TENS1_HUMAN
θ value	1.38821 (rank : 96)	NC score	0.044955 (rank : 130)
Query Neighborhood Hits	188	Target Neighborhood Hits	400	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

ZO1_MOUSE
θ value	1.38821 (rank : 97)	NC score	0.027763 (rank : 148)
Query Neighborhood Hits	188	Target Neighborhood Hits	453	Shared Neighborhood Hits	28
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

BMX_MOUSE
θ value	1.81305 (rank : 98)	NC score	0.021759 (rank : 162)
Query Neighborhood Hits	188	Target Neighborhood Hits	912	Shared Neighborhood Hits	40
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BOC_HUMAN
θ value	1.81305 (rank : 99)	NC score	0.006394 (rank : 203)
Query Neighborhood Hits	188	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

ENAH_MOUSE
θ value	1.81305 (rank : 100)	NC score	0.049897 (rank : 120)
Query Neighborhood Hits	188	Target Neighborhood Hits	919	Shared Neighborhood Hits	46
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GNAS1_MOUSE
θ value	1.81305 (rank : 101)	NC score	0.017171 (rank : 176)
Query Neighborhood Hits	188	Target Neighborhood Hits	651	Shared Neighborhood Hits	32
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

KPCD1_HUMAN
θ value	1.81305 (rank : 102)	NC score	0.005202 (rank : 206)
Query Neighborhood Hits	188	Target Neighborhood Hits	901	Shared Neighborhood Hits	14
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

NOLC1_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.052996 (rank : 116)
Query Neighborhood Hits	188	Target Neighborhood Hits	452	Shared Neighborhood Hits	24
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PDZD2_HUMAN
θ value	1.81305 (rank : 104)	NC score	0.045171 (rank : 128)
Query Neighborhood Hits	188	Target Neighborhood Hits	772	Shared Neighborhood Hits	58
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SETBP_HUMAN
θ value	1.81305 (rank : 105)	NC score	0.054279 (rank : 112)
Query Neighborhood Hits	188	Target Neighborhood Hits	305	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SGIP1_MOUSE
θ value	1.81305 (rank : 106)	NC score	0.073786 (rank : 80)
Query Neighborhood Hits	188	Target Neighborhood Hits	180	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

UBP31_HUMAN
θ value	1.81305 (rank : 107)	NC score	0.020399 (rank : 166)
Query Neighborhood Hits	188	Target Neighborhood Hits	293	Shared Neighborhood Hits	15
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

XRN1_MOUSE
θ value	1.81305 (rank : 108)	NC score	0.020092 (rank : 168)
Query Neighborhood Hits	188	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	P97789, O35651, P97790, Q3TE44, Q3TRE9, Q3UQL5	Gene names	Xrn1, Dhm2, Exo, Sep1
Domain Architecture	No domain graphic available
Description	5'-3' exoribonuclease 1 (EC 3.1.11.-) (mXRN1) (Strand-exchange protein 1 homolog) (Protein Dhm2).

ZIMP7_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.023019 (rank : 159)
Query Neighborhood Hits	188	Target Neighborhood Hits	290	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

CHD1_HUMAN
θ value	2.36792 (rank : 110)	NC score	0.009395 (rank : 196)
Query Neighborhood Hits	188	Target Neighborhood Hits	337	Shared Neighborhood Hits	11
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

HRX_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.029543 (rank : 147)
Query Neighborhood Hits	188	Target Neighborhood Hits	825	Shared Neighborhood Hits	42
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

PAK7_HUMAN
θ value	2.36792 (rank : 112)	NC score	0.001859 (rank : 211)
Query Neighborhood Hits	188	Target Neighborhood Hits	875	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

SRRM1_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.085560 (rank : 63)
Query Neighborhood Hits	188	Target Neighborhood Hits	690	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TACC2_MOUSE
θ value	2.36792 (rank : 114)	NC score	0.042805 (rank : 133)
Query Neighborhood Hits	188	Target Neighborhood Hits	774	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

C43BP_MOUSE
θ value	3.0926 (rank : 115)	NC score	0.127941 (rank : 47)
Query Neighborhood Hits	188	Target Neighborhood Hits	91	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

DOK2_MOUSE
θ value	3.0926 (rank : 116)	NC score	0.043123 (rank : 131)
Query Neighborhood Hits	188	Target Neighborhood Hits	244	Shared Neighborhood Hits	26
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

IRS2_MOUSE
θ value	3.0926 (rank : 117)	NC score	0.137817 (rank : 38)
Query Neighborhood Hits	188	Target Neighborhood Hits	248	Shared Neighborhood Hits	37
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

OSBP2_HUMAN
θ value	3.0926 (rank : 118)	NC score	0.083538 (rank : 65)
Query Neighborhood Hits	188	Target Neighborhood Hits	154	Shared Neighborhood Hits	51
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

SC24D_HUMAN
θ value	3.0926 (rank : 119)	NC score	0.038724 (rank : 137)
Query Neighborhood Hits	188	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

BAZ2B_HUMAN
θ value	4.03905 (rank : 120)	NC score	0.025010 (rank : 154)
Query Neighborhood Hits	188	Target Neighborhood Hits	803	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CYH2_HUMAN
θ value	4.03905 (rank : 121)	NC score	0.079534 (rank : 69)
Query Neighborhood Hits	188	Target Neighborhood Hits	175	Shared Neighborhood Hits	50
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	4.03905 (rank : 122)	NC score	0.079535 (rank : 68)
Query Neighborhood Hits	188	Target Neighborhood Hits	171	Shared Neighborhood Hits	50
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

DREB_HUMAN
θ value	4.03905 (rank : 123)	NC score	0.024328 (rank : 155)
Query Neighborhood Hits	188	Target Neighborhood Hits	450	Shared Neighborhood Hits	18
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

KIF1A_MOUSE
θ value	4.03905 (rank : 124)	NC score	0.018215 (rank : 173)
Query Neighborhood Hits	188	Target Neighborhood Hits	239	Shared Neighborhood Hits	13
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

LDB3_HUMAN
θ value	4.03905 (rank : 125)	NC score	0.018943 (rank : 169)
Query Neighborhood Hits	188	Target Neighborhood Hits	497	Shared Neighborhood Hits	30
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

MUC7_HUMAN
θ value	4.03905 (rank : 126)	NC score	0.052584 (rank : 117)
Query Neighborhood Hits	188	Target Neighborhood Hits	538	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

OBSCN_HUMAN
θ value	4.03905 (rank : 127)	NC score	0.004217 (rank : 207)
Query Neighborhood Hits	188	Target Neighborhood Hits	1931	Shared Neighborhood Hits	46
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

OSBL6_HUMAN
θ value	4.03905 (rank : 128)	NC score	0.057481 (rank : 105)
Query Neighborhood Hits	188	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
θ value	4.03905 (rank : 129)	NC score	0.057796 (rank : 104)
Query Neighborhood Hits	188	Target Neighborhood Hits	105	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

PDLI5_MOUSE
θ value	4.03905 (rank : 130)	NC score	0.018471 (rank : 171)
Query Neighborhood Hits	188	Target Neighborhood Hits	287	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PLEK2_HUMAN
θ value	4.03905 (rank : 131)	NC score	0.188426 (rank : 20)
Query Neighborhood Hits	188	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

RAD18_HUMAN
θ value	4.03905 (rank : 132)	NC score	0.018461 (rank : 172)
Query Neighborhood Hits	188	Target Neighborhood Hits	284	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NS91, Q58F55, Q9NRT6	Gene names	RAD18, RNF73
Domain Architecture
Description	Postreplication repair protein RAD18 (hRAD18) (hHR18) (RING finger protein 73).

RBP2_MOUSE
θ value	4.03905 (rank : 133)	NC score	0.009482 (rank : 195)
Query Neighborhood Hits	188	Target Neighborhood Hits	232	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

SET1A_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.036080 (rank : 138)
Query Neighborhood Hits	188	Target Neighborhood Hits	690	Shared Neighborhood Hits	30
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

TCOF_MOUSE
θ value	4.03905 (rank : 135)	NC score	0.025998 (rank : 153)
Query Neighborhood Hits	188	Target Neighborhood Hits	471	Shared Neighborhood Hits	27
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

ZN268_HUMAN
θ value	4.03905 (rank : 136)	NC score	-0.002654 (rank : 216)
Query Neighborhood Hits	188	Target Neighborhood Hits	753	Shared Neighborhood Hits	8
SwissProt Accessions	Q14587, Q96RH4, Q9BZJ9	Gene names	ZNF268
Domain Architecture
Description	Zinc finger protein 268 (Zinc finger protein HZF3).

BAG3_MOUSE
θ value	5.27518 (rank : 137)	NC score	0.040351 (rank : 135)
Query Neighborhood Hits	188	Target Neighborhood Hits	513	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CENB1_HUMAN
θ value	5.27518 (rank : 138)	NC score	0.071349 (rank : 84)
Query Neighborhood Hits	188	Target Neighborhood Hits	383	Shared Neighborhood Hits	44
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CLMN_MOUSE
θ value	5.27518 (rank : 139)	NC score	0.010335 (rank : 193)
Query Neighborhood Hits	188	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

DOK3_MOUSE
θ value	5.27518 (rank : 140)	NC score	0.020151 (rank : 167)
Query Neighborhood Hits	188	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZK7	Gene names	Dok3, Dokl
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3) (P62(dok)-like protein) (DOK-L).

DYH5_HUMAN
θ value	5.27518 (rank : 141)	NC score	0.014311 (rank : 182)
Query Neighborhood Hits	188	Target Neighborhood Hits	323	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

DYH5_MOUSE
θ value	5.27518 (rank : 142)	NC score	0.013885 (rank : 183)
Query Neighborhood Hits	188	Target Neighborhood Hits	286	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

EGFR_MOUSE
θ value	5.27518 (rank : 143)	NC score	0.005429 (rank : 205)
Query Neighborhood Hits	188	Target Neighborhood Hits	927	Shared Neighborhood Hits	16
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

GLIS3_HUMAN
θ value	5.27518 (rank : 144)	NC score	0.000007 (rank : 215)
Query Neighborhood Hits	188	Target Neighborhood Hits	758	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NEA6	Gene names	GLIS3, ZNF515
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515).

HCN4_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.011780 (rank : 188)
Query Neighborhood Hits	188	Target Neighborhood Hits	303	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

LDB3_MOUSE
θ value	5.27518 (rank : 146)	NC score	0.022675 (rank : 160)
Query Neighborhood Hits	188	Target Neighborhood Hits	510	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LRTM3_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.001453 (rank : 214)
Query Neighborhood Hits	188	Target Neighborhood Hits	290	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

MEGF9_MOUSE
θ value	5.27518 (rank : 148)	NC score	0.013412 (rank : 184)
Query Neighborhood Hits	188	Target Neighborhood Hits	896	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

PLEK2_MOUSE
θ value	5.27518 (rank : 149)	NC score	0.187219 (rank : 21)
Query Neighborhood Hits	188	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

SHPS1_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.020479 (rank : 165)
Query Neighborhood Hits	188	Target Neighborhood Hits	455	Shared Neighborhood Hits	4
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

T240L_MOUSE
θ value	5.27518 (rank : 151)	NC score	0.020686 (rank : 164)
Query Neighborhood Hits	188	Target Neighborhood Hits	143	Shared Neighborhood Hits	10
SwissProt Accessions	Q6JPI3, Q3TRF4, Q3UQI8, Q80TM3, Q80WQ0	Gene names	Thrap2, Kiaa1025, Trap240l
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

TFE2_HUMAN
θ value	5.27518 (rank : 152)	NC score	0.014683 (rank : 180)
Query Neighborhood Hits	188	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

ZN335_HUMAN
θ value	5.27518 (rank : 153)	NC score	0.003925 (rank : 209)
Query Neighborhood Hits	188	Target Neighborhood Hits	973	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

AUTS2_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.040105 (rank : 136)
Query Neighborhood Hits	188	Target Neighborhood Hits	342	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

BRDT_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.020781 (rank : 163)
Query Neighborhood Hits	188	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

CELR3_HUMAN
θ value	6.88961 (rank : 156)	NC score	0.002340 (rank : 210)
Query Neighborhood Hits	188	Target Neighborhood Hits	680	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

CENB5_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.073784 (rank : 81)
Query Neighborhood Hits	188	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

DDEF1_MOUSE
θ value	6.88961 (rank : 158)	NC score	0.048310 (rank : 124)
Query Neighborhood Hits	188	Target Neighborhood Hits	592	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DMD_MOUSE
θ value	6.88961 (rank : 159)	NC score	0.011141 (rank : 191)
Query Neighborhood Hits	188	Target Neighborhood Hits	1111	Shared Neighborhood Hits	23
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DOK2_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.030763 (rank : 145)
Query Neighborhood Hits	188	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

FA5_HUMAN
θ value	6.88961 (rank : 161)	NC score	0.010300 (rank : 194)
Query Neighborhood Hits	188	Target Neighborhood Hits	172	Shared Neighborhood Hits	11
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

FARP1_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.033394 (rank : 142)
Query Neighborhood Hits	188	Target Neighborhood Hits	241	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

LTBP2_MOUSE
θ value	6.88961 (rank : 163)	NC score	0.001726 (rank : 213)
Query Neighborhood Hits	188	Target Neighborhood Hits	617	Shared Neighborhood Hits	14
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MAGE1_HUMAN
θ value	6.88961 (rank : 164)	NC score	0.049442 (rank : 121)
Query Neighborhood Hits	188	Target Neighborhood Hits	1389	Shared Neighborhood Hits	81
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MUC5B_HUMAN
θ value	6.88961 (rank : 165)	NC score	0.030099 (rank : 146)
Query Neighborhood Hits	188	Target Neighborhood Hits	1020	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NACAM_MOUSE
θ value	6.88961 (rank : 166)	NC score	0.073855 (rank : 79)
Query Neighborhood Hits	188	Target Neighborhood Hits	1866	Shared Neighborhood Hits	85
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NR1D1_HUMAN
θ value	6.88961 (rank : 167)	NC score	0.007605 (rank : 200)
Query Neighborhood Hits	188	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

PI5PA_HUMAN
θ value	6.88961 (rank : 168)	NC score	0.035926 (rank : 139)
Query Neighborhood Hits	188	Target Neighborhood Hits	749	Shared Neighborhood Hits	50
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

ZDHC1_HUMAN
θ value	6.88961 (rank : 169)	NC score	0.010552 (rank : 192)
Query Neighborhood Hits	188	Target Neighborhood Hits	84	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WTX9, O15461	Gene names	ZDHHC1, C16orf1, ZNF377
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) (DHHC- domain-containing cysteine-rich protein 1).

ZDHC8_HUMAN
θ value	6.88961 (rank : 170)	NC score	0.027274 (rank : 150)
Query Neighborhood Hits	188	Target Neighborhood Hits	234	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

ZN687_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.001859 (rank : 212)
Query Neighborhood Hits	188	Target Neighborhood Hits	913	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

BCOR_HUMAN
θ value	8.99809 (rank : 172)	NC score	0.018478 (rank : 170)
Query Neighborhood Hits	188	Target Neighborhood Hits	609	Shared Neighborhood Hits	37
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

C43BP_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.107422 (rank : 56)
Query Neighborhood Hits	188	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CCDC4_HUMAN
θ value	8.99809 (rank : 174)	NC score	0.026960 (rank : 151)
Query Neighborhood Hits	188	Target Neighborhood Hits	104	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

CD2AP_MOUSE
θ value	8.99809 (rank : 175)	NC score	0.011172 (rank : 190)
Query Neighborhood Hits	188	Target Neighborhood Hits	336	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2L5_MOUSE
θ value	8.99809 (rank : 176)	NC score	0.004006 (rank : 208)
Query Neighborhood Hits	188	Target Neighborhood Hits	1011	Shared Neighborhood Hits	22
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CDSN_HUMAN
θ value	8.99809 (rank : 177)	NC score	0.018104 (rank : 174)
Query Neighborhood Hits	188	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q15517, O43509, Q5SQ85, Q5STD2, Q7LA70, Q7LA71, Q86Z04, Q8IZU4, Q8IZU5, Q8IZU6, Q8N5P3, Q95IF9, Q9NP52, Q9NPE0, Q9NPG5, Q9NRH4, Q9NRH5, Q9NRH6, Q9NRH7, Q9NRH8, Q9UBH8, Q9UIN6, Q9UIN7, Q9UIN8, Q9UIN9, Q9UIP0	Gene names	CDSN
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor (S protein).

EP400_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.013352 (rank : 186)
Query Neighborhood Hits	188	Target Neighborhood Hits	556	Shared Neighborhood Hits	30
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

GGA3_MOUSE
θ value	8.99809 (rank : 179)	NC score	0.011507 (rank : 189)
Query Neighborhood Hits	188	Target Neighborhood Hits	148	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

HN1_HUMAN
θ value	8.99809 (rank : 180)	NC score	0.024292 (rank : 156)
Query Neighborhood Hits	188	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UK76, Q53FG7, Q7Z2D2, Q7Z2F0	Gene names	HN1, ARM2
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1 protein (Androgen-regulated protein 2).

OSBL9_HUMAN
θ value	8.99809 (rank : 181)	NC score	0.064829 (rank : 90)
Query Neighborhood Hits	188	Target Neighborhood Hits	138	Shared Neighborhood Hits	40
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PLXB1_HUMAN
θ value	8.99809 (rank : 182)	NC score	0.008353 (rank : 198)
Query Neighborhood Hits	188	Target Neighborhood Hits	360	Shared Neighborhood Hits	28
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

RAI1_HUMAN
θ value	8.99809 (rank : 183)	NC score	0.022386 (rank : 161)
Query Neighborhood Hits	188	Target Neighborhood Hits	360	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RFX2_HUMAN
θ value	8.99809 (rank : 184)	NC score	0.006409 (rank : 202)
Query Neighborhood Hits	188	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	P48378	Gene names	RFX2
Domain Architecture
Description	DNA-binding protein RFX2.

SPTB2_MOUSE
θ value	8.99809 (rank : 185)	NC score	0.012956 (rank : 187)
Query Neighborhood Hits	188	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SYBU_MOUSE
θ value	8.99809 (rank : 186)	NC score	0.008708 (rank : 197)
Query Neighborhood Hits	188	Target Neighborhood Hits	214	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHS8, Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BI27	Gene names	Sybu, Golsyn, Kiaa1472
Domain Architecture	No domain graphic available
Description	Syntabulin (Syntaxin-1-binding protein) (Golgi-localized syntaphilin- related protein) (m-Golsyn).

SYNJ1_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.034945 (rank : 141)
Query Neighborhood Hits	188	Target Neighborhood Hits	516	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

ZDHC8_MOUSE
θ value	8.99809 (rank : 188)	NC score	0.026423 (rank : 152)
Query Neighborhood Hits	188	Target Neighborhood Hits	243	Shared Neighborhood Hits	20
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

3BP2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.057318 (rank : 106)
Query Neighborhood Hits	188	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.050287 (rank : 119)
Query Neighborhood Hits	188	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

BTBDC_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.053460 (rank : 115)
Query Neighborhood Hits	188	Target Neighborhood Hits	248	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CENA1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.057163 (rank : 107)
Query Neighborhood Hits	188	Target Neighborhood Hits	87	Shared Neighborhood Hits	34
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.058028 (rank : 103)
Query Neighborhood Hits	188	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENB2_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.077872 (rank : 72)
Query Neighborhood Hits	188	Target Neighborhood Hits	425	Shared Neighborhood Hits	49
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CEND3_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.067061 (rank : 87)
Query Neighborhood Hits	188	Target Neighborhood Hits	275	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.064812 (rank : 91)
Query Neighborhood Hits	188	Target Neighborhood Hits	228	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CYH1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.086681 (rank : 62)
Query Neighborhood Hits	188	Target Neighborhood Hits	184	Shared Neighborhood Hits	55
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.084372 (rank : 64)
Query Neighborhood Hits	188	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.075277 (rank : 77)
Query Neighborhood Hits	188	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.080399 (rank : 67)
Query Neighborhood Hits	188	Target Neighborhood Hits	148	Shared Neighborhood Hits	51
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.075995 (rank : 75)
Query Neighborhood Hits	188	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.075728 (rank : 76)
Query Neighborhood Hits	188	Target Neighborhood Hits	134	Shared Neighborhood Hits	48
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

DGKH_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.055239 (rank : 110)
Query Neighborhood Hits	188	Target Neighborhood Hits	255	Shared Neighborhood Hits	44
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MDC1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.062137 (rank : 95)
Query Neighborhood Hits	188	Target Neighborhood Hits	1446	Shared Neighborhood Hits	76
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.059016 (rank : 101)
Query Neighborhood Hits	188	Target Neighborhood Hits	998	Shared Neighborhood Hits	73
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MUC1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.056863 (rank : 108)
Query Neighborhood Hits	188	Target Neighborhood Hits	975	Shared Neighborhood Hits	60
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PKHA3_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.069006 (rank : 85)
Query Neighborhood Hits	188	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.063699 (rank : 93)
Query Neighborhood Hits	188	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHB2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.052518 (rank : 118)
Query Neighborhood Hits	188	Target Neighborhood Hits	48	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PYGO2_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.054013 (rank : 114)
Query Neighborhood Hits	188	Target Neighborhood Hits	189	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

RASA3_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.079252 (rank : 71)
Query Neighborhood Hits	188	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA3_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.076875 (rank : 74)
Query Neighborhood Hits	188	Target Neighborhood Hits	144	Shared Neighborhood Hits	27
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RHG25_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.116854 (rank : 51)
Query Neighborhood Hits	188	Target Neighborhood Hits	550	Shared Neighborhood Hits	58
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.094549 (rank : 58)
Query Neighborhood Hits	188	Target Neighborhood Hits	492	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TARSH_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.061579 (rank : 96)
Query Neighborhood Hits	188	Target Neighborhood Hits	768	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.067474 (rank : 86)
Query Neighborhood Hits	188	Target Neighborhood Hits	392	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

Hits sorted by NC score

GAB2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	188	Target Neighborhood Hits	188	Shared Neighborhood Hits	188
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
NC score	0.968699 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	188	Target Neighborhood Hits	220	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAB1_MOUSE
NC score	0.884019 (rank : 3)	θ value	1.21547e-113 (rank : 4)
Query Neighborhood Hits	188	Target Neighborhood Hits	233	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_HUMAN
NC score	0.878932 (rank : 4)	θ value	1.09934e-114 (rank : 3)
Query Neighborhood Hits	188	Target Neighborhood Hits	279	Shared Neighborhood Hits	78
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA1_MOUSE
NC score	0.401204 (rank : 5)	θ value	1.69304e-06 (rank : 8)
Query Neighborhood Hits	188	Target Neighborhood Hits	120	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_HUMAN
NC score	0.389338 (rank : 6)	θ value	1.69304e-06 (rank : 7)
Query Neighborhood Hits	188	Target Neighborhood Hits	127	Shared Neighborhood Hits	61
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
NC score	0.378656 (rank : 7)	θ value	1.69304e-06 (rank : 9)
Query Neighborhood Hits	188	Target Neighborhood Hits	119	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
NC score	0.376285 (rank : 8)	θ value	7.59969e-07 (rank : 6)
Query Neighborhood Hits	188	Target Neighborhood Hits	116	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PLEK_HUMAN
NC score	0.311476 (rank : 9)	θ value	5.44631e-05 (rank : 16)
Query Neighborhood Hits	188	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
NC score	0.306591 (rank : 10)	θ value	4.1701e-05 (rank : 14)
Query Neighborhood Hits	188	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

IRS1_HUMAN
NC score	0.246857 (rank : 11)	θ value	2.88788e-06 (rank : 10)
Query Neighborhood Hits	188	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

DAPP1_MOUSE
NC score	0.245529 (rank : 12)	θ value	0.000270298 (rank : 21)
Query Neighborhood Hits	188	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.242555 (rank : 13)	θ value	0.00035302 (rank : 22)
Query Neighborhood Hits	188	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CNKR2_MOUSE
NC score	0.240909 (rank : 14)	θ value	0.000121331 (rank : 18)
Query Neighborhood Hits	188	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.240710 (rank : 15)	θ value	0.000121331 (rank : 17)
Query Neighborhood Hits	188	Target Neighborhood Hits	197	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

IRS1_MOUSE
NC score	0.237965 (rank : 16)	θ value	1.87187e-05 (rank : 11)
Query Neighborhood Hits	188	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

PHLB1_MOUSE
NC score	0.231069 (rank : 17)	θ value	5.44631e-05 (rank : 15)
Query Neighborhood Hits	188	Target Neighborhood Hits	678	Shared Neighborhood Hits	70
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CNKR1_HUMAN
NC score	0.217854 (rank : 18)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	188	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PHLB1_HUMAN
NC score	0.201659 (rank : 19)	θ value	0.00102713 (rank : 25)
Query Neighborhood Hits	188	Target Neighborhood Hits	1038	Shared Neighborhood Hits	84
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLEK2_HUMAN
NC score	0.188426 (rank : 20)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	188	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
NC score	0.187219 (rank : 21)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	188	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PHLB2_HUMAN
NC score	0.182650 (rank : 22)	θ value	0.000158464 (rank : 20)
Query Neighborhood Hits	188	Target Neighborhood Hits	964	Shared Neighborhood Hits	56
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
NC score	0.178916 (rank : 23)	θ value	0.000121331 (rank : 19)
Query Neighborhood Hits	188	Target Neighborhood Hits	1016	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA5_HUMAN
NC score	0.178295 (rank : 24)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	188	Target Neighborhood Hits	455	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_MOUSE
NC score	0.175696 (rank : 25)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	188	Target Neighborhood Hits	591	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

MRIP_HUMAN
NC score	0.169535 (rank : 26)	θ value	0.00298849 (rank : 29)
Query Neighborhood Hits	188	Target Neighborhood Hits	578	Shared Neighborhood Hits	54
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

PKHA6_HUMAN
NC score	0.166501 (rank : 27)	θ value	1.38821 (rank : 93)
Query Neighborhood Hits	188	Target Neighborhood Hits	556	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

MRIP_MOUSE
NC score	0.160852 (rank : 28)	θ value	0.00390308 (rank : 30)
Query Neighborhood Hits	188	Target Neighborhood Hits	569	Shared Neighborhood Hits	53
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

PKHA4_MOUSE
NC score	0.156691 (rank : 29)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	188	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SRRM2_HUMAN
NC score	0.156225 (rank : 30)	θ value	0.000602161 (rank : 24)
Query Neighborhood Hits	188	Target Neighborhood Hits	1296	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

DOC10_HUMAN
NC score	0.153334 (rank : 31)	θ value	2.44474e-05 (rank : 12)
Query Neighborhood Hits	188	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

TARA_MOUSE
NC score	0.152091 (rank : 32)	θ value	0.0148317 (rank : 36)
Query Neighborhood Hits	188	Target Neighborhood Hits	1133	Shared Neighborhood Hits	83
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PKHA4_HUMAN
NC score	0.148895 (rank : 33)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	188	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SRRM2_MOUSE
NC score	0.148241 (rank : 34)	θ value	3.19293e-05 (rank : 13)
Query Neighborhood Hits	188	Target Neighborhood Hits	1470	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CEND1_HUMAN
NC score	0.141663 (rank : 35)	θ value	0.00134147 (rank : 26)
Query Neighborhood Hits	188	Target Neighborhood Hits	284	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RPB1_MOUSE
NC score	0.139502 (rank : 36)	θ value	0.00134147 (rank : 28)
Query Neighborhood Hits	188	Target Neighborhood Hits	363	Shared Neighborhood Hits	35
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_HUMAN
NC score	0.139132 (rank : 37)	θ value	0.00134147 (rank : 27)
Query Neighborhood Hits	188	Target Neighborhood Hits	362	Shared Neighborhood Hits	34
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

IRS2_MOUSE
NC score	0.137817 (rank : 38)	θ value	3.0926 (rank : 117)
Query Neighborhood Hits	188	Target Neighborhood Hits	248	Shared Neighborhood Hits	37
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

RASA1_HUMAN
NC score	0.136925 (rank : 39)	θ value	0.00665767 (rank : 31)
Query Neighborhood Hits	188	Target Neighborhood Hits	258	Shared Neighborhood Hits	40
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

IRS2_HUMAN
NC score	0.133310 (rank : 40)	θ value	1.06291 (rank : 81)
Query Neighborhood Hits	188	Target Neighborhood Hits	262	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

RASA2_MOUSE
NC score	0.132970 (rank : 41)	θ value	0.00665767 (rank : 32)
Query Neighborhood Hits	188	Target Neighborhood Hits	159	Shared Neighborhood Hits	31
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CEND2_HUMAN
NC score	0.132539 (rank : 42)	θ value	0.000461057 (rank : 23)
Query Neighborhood Hits	188	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

TARA_HUMAN
NC score	0.132184 (rank : 43)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	188	Target Neighborhood Hits	1626	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SWP70_MOUSE
NC score	0.130501 (rank : 44)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	188	Target Neighborhood Hits	1097	Shared Neighborhood Hits	68
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_HUMAN
NC score	0.129157 (rank : 45)	θ value	0.0252991 (rank : 40)
Query Neighborhood Hits	188	Target Neighborhood Hits	973	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

DOCK9_MOUSE
NC score	0.128184 (rank : 46)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	188	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

C43BP_MOUSE
NC score	0.127941 (rank : 47)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	188	Target Neighborhood Hits	91	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

MYO10_HUMAN
NC score	0.120659 (rank : 48)	θ value	1.53129e-07 (rank : 5)
Query Neighborhood Hits	188	Target Neighborhood Hits	920	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TBCD2_HUMAN
NC score	0.120088 (rank : 49)	θ value	0.00869519 (rank : 34)
Query Neighborhood Hits	188	Target Neighborhood Hits	419	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

MTMR5_HUMAN
NC score	0.118587 (rank : 50)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	188	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

RHG25_HUMAN
NC score	0.116854 (rank : 51)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	188	Target Neighborhood Hits	550	Shared Neighborhood Hits	58
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

DOCK9_HUMAN
NC score	0.116513 (rank : 52)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	188	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

RASA2_HUMAN
NC score	0.112066 (rank : 53)	θ value	0.125558 (rank : 48)
Query Neighborhood Hits	188	Target Neighborhood Hits	157	Shared Neighborhood Hits	29
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CEND1_MOUSE
NC score	0.111959 (rank : 54)	θ value	0.0252991 (rank : 38)
Query Neighborhood Hits	188	Target Neighborhood Hits	260	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

MTMRD_HUMAN
NC score	0.108575 (rank : 55)	θ value	0.0563607 (rank : 44)
Query Neighborhood Hits	188	Target Neighborhood Hits	135	Shared Neighborhood Hits	42
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

C43BP_HUMAN
NC score	0.107422 (rank : 56)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	188	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

PYGO1_HUMAN
NC score	0.105080 (rank : 57)	θ value	0.0252991 (rank : 39)
Query Neighborhood Hits	188	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y3Y4	Gene names	PYGO1
Domain Architecture
Description	Pygopus homolog 1.

RHG25_MOUSE
NC score	0.094549 (rank : 58)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	188	Target Neighborhood Hits	492	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OSBP1_HUMAN
NC score	0.094406 (rank : 59)	θ value	0.813845 (rank : 75)
Query Neighborhood Hits	188	Target Neighborhood Hits	180	Shared Neighborhood Hits	46
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBP2_MOUSE
NC score	0.091808 (rank : 60)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	188	Target Neighborhood Hits	150	Shared Neighborhood Hits	51
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

SRRM1_MOUSE
NC score	0.090105 (rank : 61)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	188	Target Neighborhood Hits	966	Shared Neighborhood Hits	62
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

CYH1_HUMAN
NC score	0.086681 (rank : 62)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	188	Target Neighborhood Hits	184	Shared Neighborhood Hits	55
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

SRRM1_HUMAN
NC score	0.085560 (rank : 63)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	188	Target Neighborhood Hits	690	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

CYH1_MOUSE
NC score	0.084372 (rank : 64)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	188	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

OSBP2_HUMAN
NC score	0.083538 (rank : 65)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	188	Target Neighborhood Hits	154	Shared Neighborhood Hits	51
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

PYGO1_MOUSE
NC score	0.080479 (rank : 66)	θ value	0.0563607 (rank : 45)
Query Neighborhood Hits	188	Target Neighborhood Hits	69	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D0P5	Gene names	Pygo1
Domain Architecture
Description	Pygopus homolog 1.

CYH3_MOUSE
NC score	0.080399 (rank : 67)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	188	Target Neighborhood Hits	148	Shared Neighborhood Hits	51
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH2_MOUSE
NC score	0.079535 (rank : 68)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	188	Target Neighborhood Hits	171	Shared Neighborhood Hits	50
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.079534 (rank : 69)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	188	Target Neighborhood Hits	175	Shared Neighborhood Hits	50
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

RAPH1_HUMAN
NC score	0.079454 (rank : 70)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	188	Target Neighborhood Hits	593	Shared Neighborhood Hits	43
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA3_HUMAN
NC score	0.079252 (rank : 71)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	188	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

CENB2_HUMAN
NC score	0.077872 (rank : 72)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	188	Target Neighborhood Hits	425	Shared Neighborhood Hits	49
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

MUC15_MOUSE
NC score	0.077001 (rank : 73)	θ value	0.279714 (rank : 54)
Query Neighborhood Hits	188	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C6Z1, Q3UQC4, Q6XYQ9, Q7TMH6, Q8CE82	Gene names	Muc15
Domain Architecture	No domain graphic available
Description	Mucin-15 precursor.

RASA3_MOUSE
NC score	0.076875 (rank : 74)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	188	Target Neighborhood Hits	144	Shared Neighborhood Hits	27
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

CYH4_HUMAN
NC score	0.075995 (rank : 75)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	188	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
NC score	0.075728 (rank : 76)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	188	Target Neighborhood Hits	134	Shared Neighborhood Hits	48
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH3_HUMAN
NC score	0.075277 (rank : 77)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	188	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

PPRB_MOUSE
NC score	0.074514 (rank : 78)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	188	Target Neighborhood Hits	354	Shared Neighborhood Hits	31
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

NACAM_MOUSE
NC score	0.073855 (rank : 79)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	188	Target Neighborhood Hits	1866	Shared Neighborhood Hits	85
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SGIP1_MOUSE
NC score	0.073786 (rank : 80)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	188	Target Neighborhood Hits	180	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

CENB5_HUMAN
NC score	0.073784 (rank : 81)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	188	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

SGIP1_HUMAN
NC score	0.073659 (rank : 82)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	188	Target Neighborhood Hits	198	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SETBP_MOUSE
NC score	0.071567 (rank : 83)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	188	Target Neighborhood Hits	352	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

CENB1_HUMAN
NC score	0.071349 (rank : 84)	θ value	5.27518 (rank : 138)
Query Neighborhood Hits	188	Target Neighborhood Hits	383	Shared Neighborhood Hits	44
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

PKHA3_HUMAN
NC score	0.069006 (rank : 85)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	188	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

WASIP_MOUSE
NC score	0.067474 (rank : 86)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	188	Target Neighborhood Hits	392	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

CEND3_HUMAN
NC score	0.067061 (rank : 87)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	188	Target Neighborhood Hits	275	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

OSBL3_HUMAN
NC score	0.066043 (rank : 88)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	188	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_MOUSE
NC score	0.066021 (rank : 89)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	188	Target Neighborhood Hits	86	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL9_HUMAN
NC score	0.064829 (rank : 90)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	188	Target Neighborhood Hits	138	Shared Neighborhood Hits	40
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

CEND3_MOUSE
NC score	0.064812 (rank : 91)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	188	Target Neighborhood Hits	228	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CS007_MOUSE
NC score	0.064026 (rank : 92)	θ value	0.21417 (rank : 50)
Query Neighborhood Hits	188	Target Neighborhood Hits	464	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

PKHA3_MOUSE
NC score	0.063699 (rank : 93)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	188	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PEX5R_HUMAN
NC score	0.062447 (rank : 94)	θ value	0.0431538 (rank : 41)
Query Neighborhood Hits	188	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

MDC1_HUMAN
NC score	0.062137 (rank : 95)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	188	Target Neighborhood Hits	1446	Shared Neighborhood Hits	76
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

TARSH_HUMAN
NC score	0.061579 (rank : 96)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	188	Target Neighborhood Hits	768	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

NCOA6_HUMAN
NC score	0.061294 (rank : 97)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	188	Target Neighborhood Hits	1202	Shared Neighborhood Hits	75
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

K0460_HUMAN
NC score	0.061143 (rank : 98)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	188	Target Neighborhood Hits	357	Shared Neighborhood Hits	26
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

CENA2_MOUSE
NC score	0.061125 (rank : 99)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	188	Target Neighborhood Hits	68	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

MAGC1_HUMAN
NC score	0.060849 (rank : 100)	θ value	0.0193708 (rank : 37)
Query Neighborhood Hits	188	Target Neighborhood Hits	431	Shared Neighborhood Hits	36
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MDC1_MOUSE
NC score	0.059016 (rank : 101)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	188	Target Neighborhood Hits	998	Shared Neighborhood Hits	73
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

RASL1_MOUSE
NC score	0.058031 (rank : 102)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	188	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

CENA2_HUMAN
NC score	0.058028 (rank : 103)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	188	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

OSBL6_MOUSE
NC score	0.057796 (rank : 104)	θ value	4.03905 (rank : 129)
Query Neighborhood Hits	188	Target Neighborhood Hits	105	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_HUMAN
NC score	0.057481 (rank : 105)	θ value	4.03905 (rank : 128)
Query Neighborhood Hits	188	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

3BP2_HUMAN
NC score	0.057318 (rank : 106)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	188	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CENA1_HUMAN
NC score	0.057163 (rank : 107)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	188	Target Neighborhood Hits	87	Shared Neighborhood Hits	34
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

MUC1_HUMAN
NC score	0.056863 (rank : 108)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	188	Target Neighborhood Hits	975	Shared Neighborhood Hits	60
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PER3_HUMAN
NC score	0.055781 (rank : 109)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	188	Target Neighborhood Hits	479	Shared Neighborhood Hits	40
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

DGKH_HUMAN
NC score	0.055239 (rank : 110)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	188	Target Neighborhood Hits	255	Shared Neighborhood Hits	44
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

BSN_HUMAN
NC score	0.054841 (rank : 111)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	188	Target Neighborhood Hits	1537	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

SETBP_HUMAN
NC score	0.054279 (rank : 112)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	188	Target Neighborhood Hits	305	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

MINT_MOUSE
NC score	0.054157 (rank : 113)	θ value	0.62314 (rank : 69)
Query Neighborhood Hits	188	Target Neighborhood Hits	1514	Shared Neighborhood Hits	61
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PYGO2_HUMAN
NC score	0.054013 (rank : 114)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	188	Target Neighborhood Hits	189	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

BTBDC_HUMAN
NC score	0.053460 (rank : 115)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	188	Target Neighborhood Hits	248	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

NOLC1_HUMAN
NC score	0.052996 (rank : 116)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	188	Target Neighborhood Hits	452	Shared Neighborhood Hits	24
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

MUC7_HUMAN
NC score	0.052584 (rank : 117)	θ value	4.03905 (rank : 126)
Query Neighborhood Hits	188	Target Neighborhood Hits	538	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

PKHB2_MOUSE
NC score	0.052518 (rank : 118)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	188	Target Neighborhood Hits	48	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

3BP2_MOUSE
NC score	0.050287 (rank : 119)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	188	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ENAH_MOUSE
NC score	0.049897 (rank : 120)	θ value	1.81305 (rank : 100)
Query Neighborhood Hits	188	Target Neighborhood Hits	919	Shared Neighborhood Hits	46
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

MAGE1_HUMAN
NC score	0.049442 (rank : 121)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	188	Target Neighborhood Hits	1389	Shared Neighborhood Hits	81
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

REXO1_HUMAN
NC score	0.048888 (rank : 122)	θ value	0.813845 (rank : 76)
Query Neighborhood Hits	188	Target Neighborhood Hits	242	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

MUC2_HUMAN
NC score	0.048528 (rank : 123)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	188	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

DDEF1_MOUSE
NC score	0.048310 (rank : 124)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	188	Target Neighborhood Hits	592	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MINT_HUMAN
NC score	0.047948 (rank : 125)	θ value	1.06291 (rank : 82)
Query Neighborhood Hits	188	Target Neighborhood Hits	1291	Shared Neighborhood Hits	56
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

DCP1A_MOUSE
NC score	0.046717 (rank : 126)	θ value	0.279714 (rank : 53)
Query Neighborhood Hits	188	Target Neighborhood Hits	103	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YD3, Q6NZE3	Gene names	Dcp1a, Mitc1, Smif
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (MAD homolog 4-interacting transcription coactivator 1) (Smad4-interacting transcriptional co-activator).

AFF1_HUMAN
NC score	0.045976 (rank : 127)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	188	Target Neighborhood Hits	506	Shared Neighborhood Hits	31
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

PDZD2_HUMAN
NC score	0.045171 (rank : 128)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	188	Target Neighborhood Hits	772	Shared Neighborhood Hits	58
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SYNJ1_HUMAN
NC score	0.045161 (rank : 129)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	188	Target Neighborhood Hits	498	Shared Neighborhood Hits	39
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TENS1_HUMAN
NC score	0.044955 (rank : 130)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	188	Target Neighborhood Hits	400	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

DOK2_MOUSE
NC score	0.043123 (rank : 131)	θ value	3.0926 (rank : 116)
Query Neighborhood Hits	188	Target Neighborhood Hits	244	Shared Neighborhood Hits	26
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

SHAN1_HUMAN
NC score	0.042969 (rank : 132)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	188	Target Neighborhood Hits	1041	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TACC2_MOUSE
NC score	0.042805 (rank : 133)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	188	Target Neighborhood Hits	774	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

JIP3_HUMAN
NC score	0.041354 (rank : 134)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	188	Target Neighborhood Hits	1039	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

BAG3_MOUSE
NC score	0.040351 (rank : 135)	θ value	5.27518 (rank : 137)
Query Neighborhood Hits	188	Target Neighborhood Hits	513	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

AUTS2_HUMAN
NC score	0.040105 (rank : 136)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	188	Target Neighborhood Hits	342	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

SC24D_HUMAN
NC score	0.038724 (rank : 137)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	188	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

SET1A_HUMAN
NC score	0.036080 (rank : 138)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	188	Target Neighborhood Hits	690	Shared Neighborhood Hits	30
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

PI5PA_HUMAN
NC score	0.035926 (rank : 139)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	188	Target Neighborhood Hits	749	Shared Neighborhood Hits	50
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

CASC5_MOUSE
NC score	0.035670 (rank : 140)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	188	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

SYNJ1_MOUSE
NC score	0.034945 (rank : 141)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	188	Target Neighborhood Hits	516	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

FARP1_HUMAN
NC score	0.033394 (rank : 142)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	188	Target Neighborhood Hits	241	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

NCOR1_MOUSE
NC score	0.032714 (rank : 143)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	188	Target Neighborhood Hits	521	Shared Neighborhood Hits	29
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

UBP29_HUMAN
NC score	0.031371 (rank : 144)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	188	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBJ7	Gene names	USP29
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thioesterase 29) (Ubiquitin-specific-processing protease 29) (Deubiquitinating enzyme 29).

DOK2_HUMAN
NC score	0.030763 (rank : 145)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	188	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

MUC5B_HUMAN
NC score	0.030099 (rank : 146)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	188	Target Neighborhood Hits	1020	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

HRX_HUMAN
NC score	0.029543 (rank : 147)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	188	Target Neighborhood Hits	825	Shared Neighborhood Hits	42
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

ZO1_MOUSE
NC score	0.027763 (rank : 148)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	188	Target Neighborhood Hits	453	Shared Neighborhood Hits	28
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PDE3A_MOUSE
NC score	0.027299 (rank : 149)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	188	Target Neighborhood Hits	115	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

ZDHC8_HUMAN
NC score	0.027274 (rank : 150)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	188	Target Neighborhood Hits	234	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

CCDC4_HUMAN
NC score	0.026960 (rank : 151)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	188	Target Neighborhood Hits	104	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

ZDHC8_MOUSE
NC score	0.026423 (rank : 152)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	188	Target Neighborhood Hits	243	Shared Neighborhood Hits	20
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

TCOF_MOUSE
NC score	0.025998 (rank : 153)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	188	Target Neighborhood Hits	471	Shared Neighborhood Hits	27
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

BAZ2B_HUMAN
NC score	0.025010 (rank : 154)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	188	Target Neighborhood Hits	803	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

DREB_HUMAN
NC score	0.024328 (rank : 155)	θ value	4.03905 (rank : 123)
Query Neighborhood Hits	188	Target Neighborhood Hits	450	Shared Neighborhood Hits	18
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

HN1_HUMAN
NC score	0.024292 (rank : 156)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	188	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UK76, Q53FG7, Q7Z2D2, Q7Z2F0	Gene names	HN1, ARM2
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1 protein (Androgen-regulated protein 2).

BMX_HUMAN
NC score	0.023069 (rank : 157)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	188	Target Neighborhood Hits	942	Shared Neighborhood Hits	39
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BRDT_MOUSE
NC score	0.023050 (rank : 158)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	188	Target Neighborhood Hits	243	Shared Neighborhood Hits	14
SwissProt Accessions	Q91Y44, Q59HJ4	Gene names	Brdt, Fsrg3
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein) (Bromodomain- containing female sterile homeotic-like protein).

ZIMP7_HUMAN
NC score	0.023019 (rank : 159)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	188	Target Neighborhood Hits	290	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

LDB3_MOUSE
NC score	0.022675 (rank : 160)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	188	Target Neighborhood Hits	510	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

RAI1_HUMAN
NC score	0.022386 (rank : 161)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	188	Target Neighborhood Hits	360	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

BMX_MOUSE
NC score	0.021759 (rank : 162)	θ value	1.81305 (rank : 98)
Query Neighborhood Hits	188	Target Neighborhood Hits	912	Shared Neighborhood Hits	40
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRDT_HUMAN
NC score	0.020781 (rank : 163)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	188	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

T240L_MOUSE
NC score	0.020686 (rank : 164)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	188	Target Neighborhood Hits	143	Shared Neighborhood Hits	10
SwissProt Accessions	Q6JPI3, Q3TRF4, Q3UQI8, Q80TM3, Q80WQ0	Gene names	Thrap2, Kiaa1025, Trap240l
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

SHPS1_HUMAN
NC score	0.020479 (rank : 165)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	188	Target Neighborhood Hits	455	Shared Neighborhood Hits	4
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

UBP31_HUMAN
NC score	0.020399 (rank : 166)	θ value	1.81305 (rank : 107)
Query Neighborhood Hits	188	Target Neighborhood Hits	293	Shared Neighborhood Hits	15
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

DOK3_MOUSE
NC score	0.020151 (rank : 167)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	188	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZK7	Gene names	Dok3, Dokl
Domain Architecture	No domain graphic available
Description	Docking protein 3 (Downstream of tyrosine kinase 3) (P62(dok)-like protein) (DOK-L).

XRN1_MOUSE
NC score	0.020092 (rank : 168)	θ value	1.81305 (rank : 108)
Query Neighborhood Hits	188	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	P97789, O35651, P97790, Q3TE44, Q3TRE9, Q3UQL5	Gene names	Xrn1, Dhm2, Exo, Sep1
Domain Architecture	No domain graphic available
Description	5'-3' exoribonuclease 1 (EC 3.1.11.-) (mXRN1) (Strand-exchange protein 1 homolog) (Protein Dhm2).

LDB3_HUMAN
NC score	0.018943 (rank : 169)	θ value	4.03905 (rank : 125)
Query Neighborhood Hits	188	Target Neighborhood Hits	497	Shared Neighborhood Hits	30
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

BCOR_HUMAN
NC score	0.018478 (rank : 170)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	188	Target Neighborhood Hits	609	Shared Neighborhood Hits	37
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

PDLI5_MOUSE
NC score	0.018471 (rank : 171)	θ value	4.03905 (rank : 130)
Query Neighborhood Hits	188	Target Neighborhood Hits	287	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

RAD18_HUMAN
NC score	0.018461 (rank : 172)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	188	Target Neighborhood Hits	284	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NS91, Q58F55, Q9NRT6	Gene names	RAD18, RNF73
Domain Architecture
Description	Postreplication repair protein RAD18 (hRAD18) (hHR18) (RING finger protein 73).

KIF1A_MOUSE
NC score	0.018215 (rank : 173)	θ value	4.03905 (rank : 124)
Query Neighborhood Hits	188	Target Neighborhood Hits	239	Shared Neighborhood Hits	13
SwissProt Accessions	P33173, Q61770	Gene names	Kif1a, Atsv, Kif1
Domain Architecture
Description	Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles).

CDSN_HUMAN
NC score	0.018104 (rank : 174)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	188	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q15517, O43509, Q5SQ85, Q5STD2, Q7LA70, Q7LA71, Q86Z04, Q8IZU4, Q8IZU5, Q8IZU6, Q8N5P3, Q95IF9, Q9NP52, Q9NPE0, Q9NPG5, Q9NRH4, Q9NRH5, Q9NRH6, Q9NRH7, Q9NRH8, Q9UBH8, Q9UIN6, Q9UIN7, Q9UIN8, Q9UIN9, Q9UIP0	Gene names	CDSN
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor (S protein).

WNK4_HUMAN
NC score	0.017874 (rank : 175)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	188	Target Neighborhood Hits	1043	Shared Neighborhood Hits	31
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

GNAS1_MOUSE
NC score	0.017171 (rank : 176)	θ value	1.81305 (rank : 101)
Query Neighborhood Hits	188	Target Neighborhood Hits	651	Shared Neighborhood Hits	32
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

NCOA3_HUMAN
NC score	0.017117 (rank : 177)	θ value	1.38821 (rank : 92)
Query Neighborhood Hits	188	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

RAI14_MOUSE
NC score	0.016824 (rank : 178)	θ value	0.62314 (rank : 72)
Query Neighborhood Hits	188	Target Neighborhood Hits	1505	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

KIFC3_HUMAN
NC score	0.016021 (rank : 179)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	188	Target Neighborhood Hits	619	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

TFE2_HUMAN
NC score	0.014683 (rank : 180)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	188	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

WNK4_MOUSE
NC score	0.014419 (rank : 181)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	188	Target Neighborhood Hits	961	Shared Neighborhood Hits	29
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

DYH5_HUMAN
NC score	0.014311 (rank : 182)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	188	Target Neighborhood Hits	323	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

DYH5_MOUSE
NC score	0.013885 (rank : 183)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	188	Target Neighborhood Hits	286	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

MEGF9_MOUSE
NC score	0.013412 (rank : 184)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	188	Target Neighborhood Hits	896	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

COR2A_MOUSE
NC score	0.013364 (rank : 185)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	188	Target Neighborhood Hits	204	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0P5, Q3U6H8, Q8BW42	Gene names	Coro2a
Domain Architecture	No domain graphic available
Description	Coronin-2A.

EP400_HUMAN
NC score	0.013352 (rank : 186)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	188	Target Neighborhood Hits	556	Shared Neighborhood Hits	30
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

SPTB2_MOUSE
NC score	0.012956 (rank : 187)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	188	Target Neighborhood Hits	770	Shared Neighborhood Hits	39
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

HCN4_HUMAN
NC score	0.011780 (rank : 188)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	188	Target Neighborhood Hits	303	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

GGA3_MOUSE
NC score	0.011507 (rank : 189)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	188	Target Neighborhood Hits	148	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

CD2AP_MOUSE
NC score	0.011172 (rank : 190)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	188	Target Neighborhood Hits	336	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DMD_MOUSE
NC score	0.011141 (rank : 191)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	188	Target Neighborhood Hits	1111	Shared Neighborhood Hits	23
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

ZDHC1_HUMAN
NC score	0.010552 (rank : 192)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	188	Target Neighborhood Hits	84	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WTX9, O15461	Gene names	ZDHHC1, C16orf1, ZNF377
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) (DHHC- domain-containing cysteine-rich protein 1).

CLMN_MOUSE
NC score	0.010335 (rank : 193)	θ value	5.27518 (rank : 139)
Query Neighborhood Hits	188	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

FA5_HUMAN
NC score	0.010300 (rank : 194)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	188	Target Neighborhood Hits	172	Shared Neighborhood Hits	11
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

RBP2_MOUSE
NC score	0.009482 (rank : 195)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	188	Target Neighborhood Hits	232	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

CHD1_HUMAN
NC score	0.009395 (rank : 196)	θ value	2.36792 (rank : 110)
Query Neighborhood Hits	188	Target Neighborhood Hits	337	Shared Neighborhood Hits	11
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

SYBU_MOUSE
NC score	0.008708 (rank : 197)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	188	Target Neighborhood Hits	214	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHS8, Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BI27	Gene names	Sybu, Golsyn, Kiaa1472
Domain Architecture	No domain graphic available
Description	Syntabulin (Syntaxin-1-binding protein) (Golgi-localized syntaphilin- related protein) (m-Golsyn).

PLXB1_HUMAN
NC score	0.008353 (rank : 198)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	188	Target Neighborhood Hits	360	Shared Neighborhood Hits	28
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

EGFR_HUMAN
NC score	0.007622 (rank : 199)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	188	Target Neighborhood Hits	939	Shared Neighborhood Hits	16
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

NR1D1_HUMAN
NC score	0.007605 (rank : 200)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	188	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

SP4_MOUSE
NC score	0.007395 (rank : 201)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	188	Target Neighborhood Hits	759	Shared Neighborhood Hits	11
SwissProt Accessions	Q62445	Gene names	Sp4
Domain Architecture
Description	Transcription factor Sp4.

RFX2_HUMAN
NC score	0.006409 (rank : 202)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	188	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	P48378	Gene names	RFX2
Domain Architecture
Description	DNA-binding protein RFX2.

BOC_HUMAN
NC score	0.006394 (rank : 203)	θ value	1.81305 (rank : 99)
Query Neighborhood Hits	188	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

SP4_HUMAN
NC score	0.005510 (rank : 204)	θ value	1.38821 (rank : 94)
Query Neighborhood Hits	188	Target Neighborhood Hits	749	Shared Neighborhood Hits	10
SwissProt Accessions	Q02446, O60402	Gene names	SP4
Domain Architecture
Description	Transcription factor Sp4 (SPR-1).

EGFR_MOUSE
NC score	0.005429 (rank : 205)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	188	Target Neighborhood Hits	927	Shared Neighborhood Hits	16
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

KPCD1_HUMAN
NC score	0.005202 (rank : 206)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	188	Target Neighborhood Hits	901	Shared Neighborhood Hits	14
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

OBSCN_HUMAN
NC score	0.004217 (rank : 207)	θ value	4.03905 (rank : 127)
Query Neighborhood Hits	188	Target Neighborhood Hits	1931	Shared Neighborhood Hits	46
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

CD2L5_MOUSE
NC score	0.004006 (rank : 208)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	188	Target Neighborhood Hits	1011	Shared Neighborhood Hits	22
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

ZN335_HUMAN
NC score	0.003925 (rank : 209)	θ value	5.27518 (rank : 153)
Query Neighborhood Hits	188	Target Neighborhood Hits	973	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

CELR3_HUMAN
NC score	0.002340 (rank : 210)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	188	Target Neighborhood Hits	680	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

PAK7_HUMAN
NC score	0.001859 (rank : 211)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	188	Target Neighborhood Hits	875	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

ZN687_MOUSE
NC score	0.001859 (rank : 212)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	188	Target Neighborhood Hits	913	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

LTBP2_MOUSE
NC score	0.001726 (rank : 213)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	188	Target Neighborhood Hits	617	Shared Neighborhood Hits	14
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LRTM3_MOUSE
NC score	0.001453 (rank : 214)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	188	Target Neighborhood Hits	290	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

GLIS3_HUMAN
NC score	0.000007 (rank : 215)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	188	Target Neighborhood Hits	758	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NEA6	Gene names	GLIS3, ZNF515
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515).

ZN268_HUMAN
NC score	-0.002654 (rank : 216)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	188	Target Neighborhood Hits	753	Shared Neighborhood Hits	8
SwissProt Accessions	Q14587, Q96RH4, Q9BZJ9	Gene names	ZNF268
Domain Architecture
Description	Zinc finger protein 268 (Zinc finger protein HZF3).