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Network neighborhood for query Sequence : PDE3A_MOUSE

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PDE3A_MOUSE
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE3A_HUMAN
θ value	0 (rank : 1)	NC score	0.993518 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	79	Shared Neighborhood Hits	48
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
θ value	0 (rank : 3)	NC score	0.983104 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE1C_MOUSE
θ value	3.98324e-48 (rank : 4)	NC score	0.902490 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	161	Shared Neighborhood Hits	42
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1A_MOUSE
θ value	1.15895e-47 (rank : 5)	NC score	0.911762 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
θ value	1.97686e-47 (rank : 6)	NC score	0.911189 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1C_HUMAN
θ value	1.67352e-46 (rank : 7)	NC score	0.902067 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE4A_MOUSE
θ value	2.50074e-42 (rank : 8)	NC score	0.891369 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	66	Shared Neighborhood Hits	41
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE1B_MOUSE
θ value	3.26607e-42 (rank : 9)	NC score	0.907661 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE4D_MOUSE
θ value	5.57106e-42 (rank : 10)	NC score	0.890362 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE1B_HUMAN
θ value	7.27602e-42 (rank : 11)	NC score	0.906620 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE4A_HUMAN
θ value	7.27602e-42 (rank : 12)	NC score	0.890268 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	73	Shared Neighborhood Hits	39
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4D_HUMAN
θ value	2.76489e-41 (rank : 13)	NC score	0.889414 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	122	Shared Neighborhood Hits	39
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4B_HUMAN
θ value	4.71619e-41 (rank : 14)	NC score	0.892203 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_MOUSE
θ value	1.6774e-38 (rank : 15)	NC score	0.892277 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4C_HUMAN
θ value	8.32485e-38 (rank : 16)	NC score	0.889144 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE8B_HUMAN
θ value	2.05049e-36 (rank : 17)	NC score	0.886102 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE8A_MOUSE
θ value	1.12514e-34 (rank : 18)	NC score	0.883137 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8A_HUMAN
θ value	9.52487e-34 (rank : 19)	NC score	0.883103 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7A_MOUSE
θ value	3.74554e-30 (rank : 20)	NC score	0.885875 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7A_HUMAN
θ value	4.89182e-30 (rank : 21)	NC score	0.885167 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE9A_HUMAN
θ value	7.80994e-28 (rank : 22)	NC score	0.873256 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	7.80994e-28 (rank : 23)	NC score	0.876977 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE7B_MOUSE
θ value	1.73987e-27 (rank : 24)	NC score	0.880270 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
θ value	3.28125e-26 (rank : 25)	NC score	0.878054 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE2A_MOUSE
θ value	2.06002e-20 (rank : 26)	NC score	0.794497 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	4.58923e-20 (rank : 27)	NC score	0.793466 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
θ value	5.07402e-19 (rank : 28)	NC score	0.768194 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
θ value	1.13037e-18 (rank : 29)	NC score	0.767562 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6C_HUMAN
θ value	2.60593e-15 (rank : 30)	NC score	0.732570 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_MOUSE
θ value	3.40345e-15 (rank : 31)	NC score	0.722965 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6A_HUMAN
θ value	5.8054e-15 (rank : 32)	NC score	0.726482 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6C_MOUSE
θ value	5.8054e-15 (rank : 33)	NC score	0.732929 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6B_HUMAN
θ value	7.58209e-15 (rank : 34)	NC score	0.722654 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
θ value	1.42992e-13 (rank : 35)	NC score	0.718132 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE5A_HUMAN
θ value	9.26847e-13 (rank : 36)	NC score	0.735061 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_MOUSE
θ value	4.59992e-12 (rank : 37)	NC score	0.736289 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
θ value	1.133e-10 (rank : 38)	NC score	0.752797 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

CIC_MOUSE
θ value	0.0330416 (rank : 39)	NC score	0.035396 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	742	Shared Neighborhood Hits	34
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

MAGE1_HUMAN
θ value	0.0961366 (rank : 40)	NC score	0.017297 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	1389	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CSPG3_HUMAN
θ value	0.125558 (rank : 41)	NC score	0.010038 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	676	Shared Neighborhood Hits	14
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CIC_HUMAN
θ value	0.163984 (rank : 42)	NC score	0.031373 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	992	Shared Neighborhood Hits	36
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

NCOA6_MOUSE
θ value	0.163984 (rank : 43)	NC score	0.031921 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	1076	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ZIMP7_MOUSE
θ value	0.21417 (rank : 44)	NC score	0.020092 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	566	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

GAB2_HUMAN
θ value	0.279714 (rank : 45)	NC score	0.027299 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

NCOA6_HUMAN
θ value	0.279714 (rank : 46)	NC score	0.031085 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	1202	Shared Neighborhood Hits	35
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

HGS_MOUSE
θ value	0.47712 (rank : 47)	NC score	0.016141 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	589	Shared Neighborhood Hits	17
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

OGFR_HUMAN
θ value	0.62314 (rank : 48)	NC score	0.014349 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	1582	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SYNE2_HUMAN
θ value	0.62314 (rank : 49)	NC score	0.004966 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	1323	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MAGC1_HUMAN
θ value	0.813845 (rank : 50)	NC score	0.016990 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	431	Shared Neighborhood Hits	25
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MAST2_MOUSE
θ value	0.813845 (rank : 51)	NC score	-0.000601 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	1110	Shared Neighborhood Hits	14
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PCDA3_HUMAN
θ value	0.813845 (rank : 52)	NC score	0.002382 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y5H8, O75286	Gene names	PCDHA3
Domain Architecture
Description	Protocadherin alpha 3 precursor (PCDH-alpha3).

MTSS1_MOUSE
θ value	1.06291 (rank : 53)	NC score	0.018951 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	592	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

RFWD2_MOUSE
θ value	1.06291 (rank : 54)	NC score	0.006710 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	535	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

TARA_HUMAN
θ value	1.06291 (rank : 55)	NC score	0.014329 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	1626	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GP112_HUMAN
θ value	1.38821 (rank : 56)	NC score	0.012178 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	441	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

GTSE1_HUMAN
θ value	1.38821 (rank : 57)	NC score	0.022548 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	193	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYZ3, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557	Gene names	GTSE1
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (B99 homolog).

MDC1_MOUSE
θ value	1.81305 (rank : 58)	NC score	0.024676 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	998	Shared Neighborhood Hits	39
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PCLO_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.011857 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	2275	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RGS3_MOUSE
θ value	1.81305 (rank : 60)	NC score	0.008929 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	1621	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TENS4_HUMAN
θ value	1.81305 (rank : 61)	NC score	0.018601 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

GAB2_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.021980 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GPR97_HUMAN
θ value	2.36792 (rank : 63)	NC score	0.012366 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q86Y34, Q6ZMF4, Q86SL9, Q8IZF1	Gene names	GPR97, PGR26
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor (G-protein coupled receptor PGR26).

IASPP_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.005998 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	1024	Shared Neighborhood Hits	21
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP4_MOUSE
θ value	2.36792 (rank : 65)	NC score	0.007387 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	593	Shared Neighborhood Hits	8
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

KPCT_MOUSE
θ value	2.36792 (rank : 66)	NC score	-0.002500 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	895	Shared Neighborhood Hits	6
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

RAI1_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.014072 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	360	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

CSKI1_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.005116 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	997	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CUTL1_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.003721 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	1574	Shared Neighborhood Hits	30
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

MAPK2_HUMAN
θ value	3.0926 (rank : 70)	NC score	-0.000514 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	844	Shared Neighborhood Hits	7
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	3.0926 (rank : 71)	NC score	-0.000459 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	831	Shared Neighborhood Hits	7
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PCBP3_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.016061 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	P57721, Q8N9K6, Q96EP6	Gene names	PCBP3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP3_MOUSE
θ value	3.0926 (rank : 73)	NC score	0.016064 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	P57722, Q8BSB0, Q8C544	Gene names	Pcbp3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

RP3A_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.005612 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	510	Shared Neighborhood Hits	17
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SRRM2_MOUSE
θ value	3.0926 (rank : 75)	NC score	0.028449 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	1470	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TGON2_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.012115 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	1037	Shared Neighborhood Hits	27
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ADA2A_HUMAN
θ value	4.03905 (rank : 77)	NC score	-0.002638 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

CAD26_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.002679 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IXH8, Q8TCH3, Q9BQN4, Q9NRU1	Gene names	CDH26
Domain Architecture
Description	Cadherin-like protein 26 precursor (Cadherin-like protein VR20).

GPR97_MOUSE
θ value	4.03905 (rank : 79)	NC score	0.012128 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0T6	Gene names	Gpr97
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor.

HCN2_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.006953 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	278	Shared Neighborhood Hits	23
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

PCBP2_HUMAN
θ value	4.03905 (rank : 81)	NC score	0.014713 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q15366, Q6PKG5	Gene names	PCBP2
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (hnRNP-E2).

PCBP2_MOUSE
θ value	4.03905 (rank : 82)	NC score	0.014731 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	Q61990, Q61383, Q62042	Gene names	Pcbp2, Cbp, Hnrnpx, Hnrpx
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous nuclear ribonucleoprotein X) (hnRNP X) (CTBP) (CBP).

PRDM2_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.006215 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	1135	Shared Neighborhood Hits	29
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PRKN2_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.009328 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

TAF12_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.015467 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q16514, Q15775	Gene names	TAF12, TAF15, TAF2J, TAFII20
Domain Architecture
Description	Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15).

BSN_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.014887 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	2057	Shared Neighborhood Hits	44
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CTCF_MOUSE
θ value	5.27518 (rank : 87)	NC score	-0.004578 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	796	Shared Neighborhood Hits	7
SwissProt Accessions	Q61164	Gene names	Ctcf
Domain Architecture
Description	Transcriptional repressor CTCF (CCCTC-binding factor) (CTCFL paralog) (11-zinc finger protein).

DAB1_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.008939 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	145	Shared Neighborhood Hits	8
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

DREB_MOUSE
θ value	5.27518 (rank : 89)	NC score	0.007775 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	446	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

REPS1_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.007575 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

ANGP2_MOUSE
θ value	6.88961 (rank : 91)	NC score	0.005804 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	397	Shared Neighborhood Hits	6
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

BSN_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.015843 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	1537	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CSPG2_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.003675 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	681	Shared Neighborhood Hits	11
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

DIDO1_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.008711 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	960	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

FXL19_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.009018 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	147	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

FXL19_MOUSE
θ value	6.88961 (rank : 96)	NC score	0.011718 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

IWS1_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.008328 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	1241	Shared Neighborhood Hits	31
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JADE2_MOUSE
θ value	6.88961 (rank : 98)	NC score	0.005521 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	560	Shared Neighborhood Hits	21
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

MBD5_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.014024 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

TCF7_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.009489 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

AKAP2_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.009058 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	507	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

AKAP2_MOUSE
θ value	8.99809 (rank : 102)	NC score	0.010959 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	385	Shared Neighborhood Hits	17
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

CAC1E_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.001624 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAD26_MOUSE
θ value	8.99809 (rank : 104)	NC score	0.003635 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	153	Shared Neighborhood Hits	5
SwissProt Accessions	P59862	Gene names	Cdh26
Domain Architecture
Description	Cadherin-like protein 26 precursor.

COTE1_HUMAN
θ value	8.99809 (rank : 105)	NC score	0.010238 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P81408	Gene names	C1orf2, COTE1
Domain Architecture	No domain graphic available
Description	Protein COTE1.

DOCK6_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.003911 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

FOXQ1_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.001453 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	O70220	Gene names	Foxq1, Hfh1, Hfh1l
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1) (HFH-1l).

GON4L_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.006715 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	555	Shared Neighborhood Hits	16
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HDAC6_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.003643 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

HSN2_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.007848 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q6IFS5	Gene names	HSN2
Domain Architecture	No domain graphic available
Description	Protein HSN2 precursor.

MAST2_HUMAN
θ value	8.99809 (rank : 111)	NC score	-0.001700 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	1189	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

RBBP6_HUMAN
θ value	8.99809 (rank : 112)	NC score	0.008889 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	1135	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SNX18_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.003463 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

UBP1_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.003979 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	259	Shared Neighborhood Hits	5
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

UBP42_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.004232 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	445	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

Hits sorted by NC score

PDE3A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_HUMAN
NC score	0.993518 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	79	Shared Neighborhood Hits	48
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
NC score	0.983104 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE1A_MOUSE
NC score	0.911762 (rank : 4)	θ value	1.15895e-47 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.911189 (rank : 5)	θ value	1.97686e-47 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_MOUSE
NC score	0.907661 (rank : 6)	θ value	3.26607e-42 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_HUMAN
NC score	0.906620 (rank : 7)	θ value	7.27602e-42 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1C_MOUSE
NC score	0.902490 (rank : 8)	θ value	3.98324e-48 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	161	Shared Neighborhood Hits	42
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1C_HUMAN
NC score	0.902067 (rank : 9)	θ value	1.67352e-46 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE4C_MOUSE
NC score	0.892277 (rank : 10)	θ value	1.6774e-38 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4B_HUMAN
NC score	0.892203 (rank : 11)	θ value	4.71619e-41 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4A_MOUSE
NC score	0.891369 (rank : 12)	θ value	2.50074e-42 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	66	Shared Neighborhood Hits	41
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4D_MOUSE
NC score	0.890362 (rank : 13)	θ value	5.57106e-42 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_HUMAN
NC score	0.890268 (rank : 14)	θ value	7.27602e-42 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	73	Shared Neighborhood Hits	39
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4D_HUMAN
NC score	0.889414 (rank : 15)	θ value	2.76489e-41 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	122	Shared Neighborhood Hits	39
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4C_HUMAN
NC score	0.889144 (rank : 16)	θ value	8.32485e-38 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE8B_HUMAN
NC score	0.886102 (rank : 17)	θ value	2.05049e-36 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE7A_MOUSE
NC score	0.885875 (rank : 18)	θ value	3.74554e-30 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE7A_HUMAN
NC score	0.885167 (rank : 19)	θ value	4.89182e-30 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE8A_MOUSE
NC score	0.883137 (rank : 20)	θ value	1.12514e-34 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8A_HUMAN
NC score	0.883103 (rank : 21)	θ value	9.52487e-34 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7B_MOUSE
NC score	0.880270 (rank : 22)	θ value	1.73987e-27 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.878054 (rank : 23)	θ value	3.28125e-26 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE9A_MOUSE
NC score	0.876977 (rank : 24)	θ value	7.80994e-28 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_HUMAN
NC score	0.873256 (rank : 25)	θ value	7.80994e-28 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE2A_MOUSE
NC score	0.794497 (rank : 26)	θ value	2.06002e-20 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.793466 (rank : 27)	θ value	4.58923e-20 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.768194 (rank : 28)	θ value	5.07402e-19 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.767562 (rank : 29)	θ value	1.13037e-18 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE10_HUMAN
NC score	0.752797 (rank : 30)	θ value	1.133e-10 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_MOUSE
NC score	0.736289 (rank : 31)	θ value	4.59992e-12 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.735061 (rank : 32)	θ value	9.26847e-13 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.732929 (rank : 33)	θ value	5.8054e-15 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.732570 (rank : 34)	θ value	2.60593e-15 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.726482 (rank : 35)	θ value	5.8054e-15 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6A_MOUSE
NC score	0.722965 (rank : 36)	θ value	3.40345e-15 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_HUMAN
NC score	0.722654 (rank : 37)	θ value	7.58209e-15 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
NC score	0.718132 (rank : 38)	θ value	1.42992e-13 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

CIC_MOUSE
NC score	0.035396 (rank : 39)	θ value	0.0330416 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	742	Shared Neighborhood Hits	34
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

NCOA6_MOUSE
NC score	0.031921 (rank : 40)	θ value	0.163984 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	1076	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

CIC_HUMAN
NC score	0.031373 (rank : 41)	θ value	0.163984 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	992	Shared Neighborhood Hits	36
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

NCOA6_HUMAN
NC score	0.031085 (rank : 42)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	1202	Shared Neighborhood Hits	35
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SRRM2_MOUSE
NC score	0.028449 (rank : 43)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	1470	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

GAB2_HUMAN
NC score	0.027299 (rank : 44)	θ value	0.279714 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

MDC1_MOUSE
NC score	0.024676 (rank : 45)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	998	Shared Neighborhood Hits	39
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

GTSE1_HUMAN
NC score	0.022548 (rank : 46)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	193	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYZ3, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557	Gene names	GTSE1
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (B99 homolog).

GAB2_MOUSE
NC score	0.021980 (rank : 47)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

ZIMP7_MOUSE
NC score	0.020092 (rank : 48)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	566	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

MTSS1_MOUSE
NC score	0.018951 (rank : 49)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	592	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

TENS4_HUMAN
NC score	0.018601 (rank : 50)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

MAGE1_HUMAN
NC score	0.017297 (rank : 51)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	1389	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAGC1_HUMAN
NC score	0.016990 (rank : 52)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	431	Shared Neighborhood Hits	25
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

HGS_MOUSE
NC score	0.016141 (rank : 53)	θ value	0.47712 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	589	Shared Neighborhood Hits	17
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

PCBP3_MOUSE
NC score	0.016064 (rank : 54)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	P57722, Q8BSB0, Q8C544	Gene names	Pcbp3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

PCBP3_HUMAN
NC score	0.016061 (rank : 55)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	P57721, Q8N9K6, Q96EP6	Gene names	PCBP3
Domain Architecture
Description	Poly(rC)-binding protein 3 (Alpha-CP3).

BSN_HUMAN
NC score	0.015843 (rank : 56)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	1537	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

TAF12_HUMAN
NC score	0.015467 (rank : 57)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q16514, Q15775	Gene names	TAF12, TAF15, TAF2J, TAFII20
Domain Architecture
Description	Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15).

BSN_MOUSE
NC score	0.014887 (rank : 58)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	2057	Shared Neighborhood Hits	44
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PCBP2_MOUSE
NC score	0.014731 (rank : 59)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	Q61990, Q61383, Q62042	Gene names	Pcbp2, Cbp, Hnrnpx, Hnrpx
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (Putative heterogeneous nuclear ribonucleoprotein X) (hnRNP X) (CTBP) (CBP).

PCBP2_HUMAN
NC score	0.014713 (rank : 60)	θ value	4.03905 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	Q15366, Q6PKG5	Gene names	PCBP2
Domain Architecture
Description	Poly(rC)-binding protein 2 (Alpha-CP2) (hnRNP-E2).

OGFR_HUMAN
NC score	0.014349 (rank : 61)	θ value	0.62314 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	1582	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TARA_HUMAN
NC score	0.014329 (rank : 62)	θ value	1.06291 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	1626	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RAI1_HUMAN
NC score	0.014072 (rank : 63)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	360	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

MBD5_HUMAN
NC score	0.014024 (rank : 64)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

GPR97_HUMAN
NC score	0.012366 (rank : 65)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q86Y34, Q6ZMF4, Q86SL9, Q8IZF1	Gene names	GPR97, PGR26
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor (G-protein coupled receptor PGR26).

GP112_HUMAN
NC score	0.012178 (rank : 66)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	441	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

GPR97_MOUSE
NC score	0.012128 (rank : 67)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	89	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0T6	Gene names	Gpr97
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor.

TGON2_HUMAN
NC score	0.012115 (rank : 68)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	1037	Shared Neighborhood Hits	27
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

PCLO_MOUSE
NC score	0.011857 (rank : 69)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	2275	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

FXL19_MOUSE
NC score	0.011718 (rank : 70)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

AKAP2_MOUSE
NC score	0.010959 (rank : 71)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	385	Shared Neighborhood Hits	17
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

COTE1_HUMAN
NC score	0.010238 (rank : 72)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P81408	Gene names	C1orf2, COTE1
Domain Architecture	No domain graphic available
Description	Protein COTE1.

CSPG3_HUMAN
NC score	0.010038 (rank : 73)	θ value	0.125558 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	676	Shared Neighborhood Hits	14
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

TCF7_MOUSE
NC score	0.009489 (rank : 74)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	277	Shared Neighborhood Hits	7
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

PRKN2_HUMAN
NC score	0.009328 (rank : 75)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	2
SwissProt Accessions	O60260, Q5TFV8, Q6Q2I6, Q8NI41, Q8NI43, Q8NI44, Q8WW07	Gene names	PARK2, PRKN
Domain Architecture	No domain graphic available
Description	Parkin (EC 6.3.2.-) (Ubiquitin E3 ligase PRKN) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2).

AKAP2_HUMAN
NC score	0.009058 (rank : 76)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	507	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

FXL19_HUMAN
NC score	0.009018 (rank : 77)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	147	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

DAB1_MOUSE
NC score	0.008939 (rank : 78)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	145	Shared Neighborhood Hits	8
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

RGS3_MOUSE
NC score	0.008929 (rank : 79)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	1621	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RBBP6_HUMAN
NC score	0.008889 (rank : 80)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	1135	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

DIDO1_HUMAN
NC score	0.008711 (rank : 81)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	960	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

IWS1_HUMAN
NC score	0.008328 (rank : 82)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	1241	Shared Neighborhood Hits	31
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

HSN2_HUMAN
NC score	0.007848 (rank : 83)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q6IFS5	Gene names	HSN2
Domain Architecture	No domain graphic available
Description	Protein HSN2 precursor.

DREB_MOUSE
NC score	0.007775 (rank : 84)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	446	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

REPS1_MOUSE
NC score	0.007575 (rank : 85)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	204	Shared Neighborhood Hits	7
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

JIP4_MOUSE
NC score	0.007387 (rank : 86)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	593	Shared Neighborhood Hits	8
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

HCN2_MOUSE
NC score	0.006953 (rank : 87)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	278	Shared Neighborhood Hits	23
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

GON4L_HUMAN
NC score	0.006715 (rank : 88)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	555	Shared Neighborhood Hits	16
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

RFWD2_MOUSE
NC score	0.006710 (rank : 89)	θ value	1.06291 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	535	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

PRDM2_HUMAN
NC score	0.006215 (rank : 90)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	1135	Shared Neighborhood Hits	29
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

IASPP_MOUSE
NC score	0.005998 (rank : 91)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	1024	Shared Neighborhood Hits	21
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANGP2_MOUSE
NC score	0.005804 (rank : 92)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	397	Shared Neighborhood Hits	6
SwissProt Accessions	O35608, Q3U1A1, Q9D2D2	Gene names	Angpt2, Agpt2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

RP3A_MOUSE
NC score	0.005612 (rank : 93)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	510	Shared Neighborhood Hits	17
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

JADE2_MOUSE
NC score	0.005521 (rank : 94)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	560	Shared Neighborhood Hits	21
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

CSKI1_HUMAN
NC score	0.005116 (rank : 95)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	997	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SYNE2_HUMAN
NC score	0.004966 (rank : 96)	θ value	0.62314 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	1323	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

UBP42_HUMAN
NC score	0.004232 (rank : 97)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	445	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

UBP1_HUMAN
NC score	0.003979 (rank : 98)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	259	Shared Neighborhood Hits	5
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

DOCK6_HUMAN
NC score	0.003911 (rank : 99)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

CUTL1_HUMAN
NC score	0.003721 (rank : 100)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	1574	Shared Neighborhood Hits	30
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CSPG2_HUMAN
NC score	0.003675 (rank : 101)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	681	Shared Neighborhood Hits	11
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

HDAC6_MOUSE
NC score	0.003643 (rank : 102)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

CAD26_MOUSE
NC score	0.003635 (rank : 103)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	153	Shared Neighborhood Hits	5
SwissProt Accessions	P59862	Gene names	Cdh26
Domain Architecture
Description	Cadherin-like protein 26 precursor.

SNX18_HUMAN
NC score	0.003463 (rank : 104)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CAD26_HUMAN
NC score	0.002679 (rank : 105)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IXH8, Q8TCH3, Q9BQN4, Q9NRU1	Gene names	CDH26
Domain Architecture
Description	Cadherin-like protein 26 precursor (Cadherin-like protein VR20).

PCDA3_HUMAN
NC score	0.002382 (rank : 106)	θ value	0.813845 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y5H8, O75286	Gene names	PCDHA3
Domain Architecture
Description	Protocadherin alpha 3 precursor (PCDH-alpha3).

CAC1E_HUMAN
NC score	0.001624 (rank : 107)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

FOXQ1_MOUSE
NC score	0.001453 (rank : 108)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	96	Shared Neighborhood Hits	5
SwissProt Accessions	O70220	Gene names	Foxq1, Hfh1, Hfh1l
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1) (HFH-1l).

MAPK2_MOUSE
NC score	-0.000459 (rank : 109)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	831	Shared Neighborhood Hits	7
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_HUMAN
NC score	-0.000514 (rank : 110)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	844	Shared Neighborhood Hits	7
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAST2_MOUSE
NC score	-0.000601 (rank : 111)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	1110	Shared Neighborhood Hits	14
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_HUMAN
NC score	-0.001700 (rank : 112)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	1189	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KPCT_MOUSE
NC score	-0.002500 (rank : 113)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	895	Shared Neighborhood Hits	6
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

ADA2A_HUMAN
NC score	-0.002638 (rank : 114)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

CTCF_MOUSE
NC score	-0.004578 (rank : 115)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	796	Shared Neighborhood Hits	7
SwissProt Accessions	Q61164	Gene names	Ctcf
Domain Architecture
Description	Transcriptional repressor CTCF (CCCTC-binding factor) (CTCFL paralog) (11-zinc finger protein).