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Network neighborhood for query Sequence : PDE8A_HUMAN

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PDE8A_HUMAN
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE8A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE8A_MOUSE
θ value	0 (rank : 2)	NC score	0.998365 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	52	Shared Neighborhood Hits	40
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8B_HUMAN
θ value	0 (rank : 3)	NC score	0.997486 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE4B_HUMAN
θ value	3.84025e-59 (rank : 4)	NC score	0.926673 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
θ value	2.48917e-58 (rank : 5)	NC score	0.927372 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
θ value	4.24587e-58 (rank : 6)	NC score	0.929286 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_HUMAN
θ value	1.36585e-56 (rank : 7)	NC score	0.922693 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	122	Shared Neighborhood Hits	38
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	1.36585e-56 (rank : 8)	NC score	0.923369 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_MOUSE
θ value	3.974e-56 (rank : 9)	NC score	0.923425 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4A_HUMAN
θ value	1.97229e-55 (rank : 10)	NC score	0.922815 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE7A_HUMAN
θ value	1.788e-48 (rank : 11)	NC score	0.929795 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
θ value	5.7518e-47 (rank : 12)	NC score	0.928692 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE1C_HUMAN
θ value	5.38352e-45 (rank : 13)	NC score	0.905375 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	9.18288e-45 (rank : 14)	NC score	0.904793 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1A_MOUSE
θ value	1.73182e-43 (rank : 15)	NC score	0.914921 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1A_HUMAN
θ value	5.03882e-43 (rank : 16)	NC score	0.913621 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE9A_HUMAN
θ value	1.46607e-42 (rank : 17)	NC score	0.916591 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	93	Shared Neighborhood Hits	39
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1B_MOUSE
θ value	9.50281e-42 (rank : 18)	NC score	0.913728 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE9A_MOUSE
θ value	9.50281e-42 (rank : 19)	NC score	0.919362 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1B_HUMAN
θ value	1.3722e-40 (rank : 20)	NC score	0.911115 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE7B_HUMAN
θ value	3.99248e-40 (rank : 21)	NC score	0.923407 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_MOUSE
θ value	3.99248e-40 (rank : 22)	NC score	0.923565 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE3A_HUMAN
θ value	3.27365e-34 (rank : 23)	NC score	0.885040 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3B_HUMAN
θ value	3.27365e-34 (rank : 24)	NC score	0.896341 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_MOUSE
θ value	9.52487e-34 (rank : 25)	NC score	0.883103 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE11_HUMAN
θ value	1.33217e-27 (rank : 26)	NC score	0.815579 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
θ value	5.59698e-26 (rank : 27)	NC score	0.814217 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6C_MOUSE
θ value	6.18819e-25 (rank : 28)	NC score	0.785807 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
θ value	1.05554e-24 (rank : 29)	NC score	0.784989 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE2A_MOUSE
θ value	3.75424e-22 (rank : 30)	NC score	0.823631 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	4.9032e-22 (rank : 31)	NC score	0.822667 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE6A_HUMAN
θ value	6.40375e-22 (rank : 32)	NC score	0.777418 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6A_MOUSE
θ value	1.09232e-21 (rank : 33)	NC score	0.773655 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_HUMAN
θ value	7.0802e-21 (rank : 34)	NC score	0.773546 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
θ value	7.0802e-21 (rank : 35)	NC score	0.772095 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE5A_HUMAN
θ value	5.07402e-19 (rank : 36)	NC score	0.785434 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_MOUSE
θ value	6.62687e-19 (rank : 37)	NC score	0.790081 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
θ value	2.28291e-11 (rank : 38)	NC score	0.788037 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

MINT_HUMAN
θ value	0.0961366 (rank : 39)	NC score	0.012536 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	1291	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CNGB3_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.006973 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

ZN436_HUMAN
θ value	2.36792 (rank : 41)	NC score	-0.004222 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	756	Shared Neighborhood Hits	2
SwissProt Accessions	Q9C0F3, Q658I9	Gene names	ZNF436, KIAA1710
Domain Architecture
Description	Zinc finger protein 436.

CEP63_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.000172 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	1005	Shared Neighborhood Hits	5
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CENPF_HUMAN
θ value	4.03905 (rank : 43)	NC score	-0.002051 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	1932	Shared Neighborhood Hits	6
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

LRP2_HUMAN
θ value	6.88961 (rank : 44)	NC score	-0.000652 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	573	Shared Neighborhood Hits	2
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

ARNT2_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.006031 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.006147 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

GOGA4_HUMAN
θ value	8.99809 (rank : 47)	NC score	-0.004217 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	2034	Shared Neighborhood Hits	5
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

Hits sorted by NC score

PDE8A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE8A_MOUSE
NC score	0.998365 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	52	Shared Neighborhood Hits	40
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8B_HUMAN
NC score	0.997486 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE7A_HUMAN
NC score	0.929795 (rank : 4)	θ value	1.788e-48 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE4C_MOUSE
NC score	0.929286 (rank : 5)	θ value	4.24587e-58 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE7A_MOUSE
NC score	0.928692 (rank : 6)	θ value	5.7518e-47 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE4C_HUMAN
NC score	0.927372 (rank : 7)	θ value	2.48917e-58 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4B_HUMAN
NC score	0.926673 (rank : 8)	θ value	3.84025e-59 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE7B_MOUSE
NC score	0.923565 (rank : 9)	θ value	3.99248e-40 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE4A_MOUSE
NC score	0.923425 (rank : 10)	θ value	3.974e-56 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.923407 (rank : 11)	θ value	3.99248e-40 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE4D_MOUSE
NC score	0.923369 (rank : 12)	θ value	1.36585e-56 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	98	Shared Neighborhood Hits	38
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4A_HUMAN
NC score	0.922815 (rank : 13)	θ value	1.97229e-55 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4D_HUMAN
NC score	0.922693 (rank : 14)	θ value	1.36585e-56 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	122	Shared Neighborhood Hits	38
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE9A_MOUSE
NC score	0.919362 (rank : 15)	θ value	9.50281e-42 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_HUMAN
NC score	0.916591 (rank : 16)	θ value	1.46607e-42 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	93	Shared Neighborhood Hits	39
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1A_MOUSE
NC score	0.914921 (rank : 17)	θ value	1.73182e-43 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1B_MOUSE
NC score	0.913728 (rank : 18)	θ value	9.50281e-42 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.913621 (rank : 19)	θ value	5.03882e-43 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_HUMAN
NC score	0.911115 (rank : 20)	θ value	1.3722e-40 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1C_HUMAN
NC score	0.905375 (rank : 21)	θ value	5.38352e-45 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
NC score	0.904793 (rank : 22)	θ value	9.18288e-45 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE3B_HUMAN
NC score	0.896341 (rank : 23)	θ value	3.27365e-34 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_HUMAN
NC score	0.885040 (rank : 24)	θ value	3.27365e-34 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.883103 (rank : 25)	θ value	9.52487e-34 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE2A_MOUSE
NC score	0.823631 (rank : 26)	θ value	3.75424e-22 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.822667 (rank : 27)	θ value	4.9032e-22 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.815579 (rank : 28)	θ value	1.33217e-27 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.814217 (rank : 29)	θ value	5.59698e-26 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE5A_MOUSE
NC score	0.790081 (rank : 30)	θ value	6.62687e-19 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
NC score	0.788037 (rank : 31)	θ value	2.28291e-11 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE6C_MOUSE
NC score	0.785807 (rank : 32)	θ value	6.18819e-25 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE5A_HUMAN
NC score	0.785434 (rank : 33)	θ value	5.07402e-19 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_HUMAN
NC score	0.784989 (rank : 34)	θ value	1.05554e-24 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.777418 (rank : 35)	θ value	6.40375e-22 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6A_MOUSE
NC score	0.773655 (rank : 36)	θ value	1.09232e-21 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_HUMAN
NC score	0.773546 (rank : 37)	θ value	7.0802e-21 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
NC score	0.772095 (rank : 38)	θ value	7.0802e-21 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

MINT_HUMAN
NC score	0.012536 (rank : 39)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	1291	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CNGB3_HUMAN
NC score	0.006973 (rank : 40)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

ARNT2_MOUSE
NC score	0.006147 (rank : 41)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.006031 (rank : 42)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

CEP63_HUMAN
NC score	0.000172 (rank : 43)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	1005	Shared Neighborhood Hits	5
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

LRP2_HUMAN
NC score	-0.000652 (rank : 44)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	573	Shared Neighborhood Hits	2
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

CENPF_HUMAN
NC score	-0.002051 (rank : 45)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	1932	Shared Neighborhood Hits	6
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

GOGA4_HUMAN
NC score	-0.004217 (rank : 46)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	2034	Shared Neighborhood Hits	5
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ZN436_HUMAN
NC score	-0.004222 (rank : 47)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	756	Shared Neighborhood Hits	2
SwissProt Accessions	Q9C0F3, Q658I9	Gene names	ZNF436, KIAA1710
Domain Architecture
Description	Zinc finger protein 436.