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Network neighborhood for query Sequence : PDE4A_HUMAN

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PDE4A_HUMAN
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE4A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	73	Target Neighborhood Hits	73	Shared Neighborhood Hits	73
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	0 (rank : 2)	NC score	0.997893 (rank : 2)
Query Neighborhood Hits	73	Target Neighborhood Hits	66	Shared Neighborhood Hits	47
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4B_HUMAN
θ value	0 (rank : 3)	NC score	0.996221 (rank : 3)
Query Neighborhood Hits	73	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
θ value	0 (rank : 4)	NC score	0.995849 (rank : 4)
Query Neighborhood Hits	73	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
θ value	0 (rank : 5)	NC score	0.995358 (rank : 5)
Query Neighborhood Hits	73	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_HUMAN
θ value	0 (rank : 6)	NC score	0.994788 (rank : 7)
Query Neighborhood Hits	73	Target Neighborhood Hits	122	Shared Neighborhood Hits	40
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	0 (rank : 7)	NC score	0.995167 (rank : 6)
Query Neighborhood Hits	73	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE1A_HUMAN
θ value	2.17557e-62 (rank : 8)	NC score	0.933000 (rank : 14)
Query Neighborhood Hits	73	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1A_MOUSE
θ value	3.71096e-62 (rank : 9)	NC score	0.933316 (rank : 12)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1C_HUMAN
θ value	1.41016e-61 (rank : 10)	NC score	0.922757 (rank : 17)
Query Neighborhood Hits	73	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	3.14151e-61 (rank : 11)	NC score	0.921866 (rank : 19)
Query Neighborhood Hits	73	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1B_MOUSE
θ value	1.23536e-57 (rank : 12)	NC score	0.933038 (rank : 13)
Query Neighborhood Hits	73	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE7B_MOUSE
θ value	5.19021e-56 (rank : 13)	NC score	0.937880 (rank : 8)
Query Neighborhood Hits	73	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8A_HUMAN
θ value	1.97229e-55 (rank : 14)	NC score	0.922815 (rank : 16)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7B_HUMAN
θ value	2.57589e-55 (rank : 15)	NC score	0.937748 (rank : 9)
Query Neighborhood Hits	73	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8B_HUMAN
θ value	1.66964e-54 (rank : 16)	NC score	0.921080 (rank : 20)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE1B_HUMAN
θ value	2.84797e-54 (rank : 17)	NC score	0.931209 (rank : 15)
Query Neighborhood Hits	73	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE7A_HUMAN
θ value	4.85792e-54 (rank : 18)	NC score	0.936082 (rank : 10)
Query Neighborhood Hits	73	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
θ value	6.56568e-51 (rank : 19)	NC score	0.935236 (rank : 11)
Query Neighborhood Hits	73	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE8A_MOUSE
θ value	1.51363e-47 (rank : 20)	NC score	0.917215 (rank : 22)
Query Neighborhood Hits	73	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE3B_HUMAN
θ value	1.56636e-44 (rank : 21)	NC score	0.907912 (rank : 23)
Query Neighborhood Hits	73	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE9A_HUMAN
θ value	3.48949e-44 (rank : 22)	NC score	0.919377 (rank : 21)
Query Neighborhood Hits	73	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	7.77379e-44 (rank : 23)	NC score	0.922698 (rank : 18)
Query Neighborhood Hits	73	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE3A_HUMAN
θ value	1.91475e-42 (rank : 24)	NC score	0.892752 (rank : 24)
Query Neighborhood Hits	73	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	7.27602e-42 (rank : 25)	NC score	0.890268 (rank : 25)
Query Neighborhood Hits	73	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE6C_MOUSE
θ value	1.24399e-33 (rank : 26)	NC score	0.806826 (rank : 33)
Query Neighborhood Hits	73	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
θ value	2.12192e-33 (rank : 27)	NC score	0.806304 (rank : 34)
Query Neighborhood Hits	73	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6B_HUMAN
θ value	3.61944e-33 (rank : 28)	NC score	0.800795 (rank : 36)
Query Neighborhood Hits	73	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
θ value	8.06329e-33 (rank : 29)	NC score	0.798898 (rank : 38)
Query Neighborhood Hits	73	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE2A_MOUSE
θ value	1.37539e-32 (rank : 30)	NC score	0.851940 (rank : 26)
Query Neighborhood Hits	73	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
θ value	1.79631e-32 (rank : 31)	NC score	0.851020 (rank : 27)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
θ value	2.34606e-32 (rank : 32)	NC score	0.831008 (rank : 28)
Query Neighborhood Hits	73	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6A_HUMAN
θ value	2.34606e-32 (rank : 33)	NC score	0.804852 (rank : 35)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE11_MOUSE
θ value	3.06405e-32 (rank : 34)	NC score	0.830845 (rank : 29)
Query Neighborhood Hits	73	Target Neighborhood Hits	50	Shared Neighborhood Hits	39
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6A_MOUSE
θ value	1.98606e-31 (rank : 35)	NC score	0.800545 (rank : 37)
Query Neighborhood Hits	73	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE5A_MOUSE
θ value	2.05525e-28 (rank : 36)	NC score	0.814285 (rank : 31)
Query Neighborhood Hits	73	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
θ value	2.77775e-25 (rank : 37)	NC score	0.830365 (rank : 30)
Query Neighborhood Hits	73	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_HUMAN
θ value	1.37858e-24 (rank : 38)	NC score	0.810521 (rank : 32)
Query Neighborhood Hits	73	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

NELF_MOUSE
θ value	0.0431538 (rank : 39)	NC score	0.030468 (rank : 40)
Query Neighborhood Hits	73	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

NHS_HUMAN
θ value	0.47712 (rank : 40)	NC score	0.032810 (rank : 39)
Query Neighborhood Hits	73	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

FARP1_HUMAN
θ value	0.62314 (rank : 41)	NC score	0.006116 (rank : 52)
Query Neighborhood Hits	73	Target Neighborhood Hits	241	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MLL3_MOUSE
θ value	0.62314 (rank : 42)	NC score	0.004948 (rank : 54)
Query Neighborhood Hits	73	Target Neighborhood Hits	1399	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

SOS1_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.013514 (rank : 46)
Query Neighborhood Hits	73	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

BRAP_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.010428 (rank : 49)
Query Neighborhood Hits	73	Target Neighborhood Hits	409	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

LMNB1_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.001116 (rank : 62)
Query Neighborhood Hits	73	Target Neighborhood Hits	714	Shared Neighborhood Hits	10
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

PRDM2_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.003449 (rank : 59)
Query Neighborhood Hits	73	Target Neighborhood Hits	1135	Shared Neighborhood Hits	10
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

SOS1_MOUSE
θ value	0.813845 (rank : 47)	NC score	0.013169 (rank : 47)
Query Neighborhood Hits	73	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

UBP34_HUMAN
θ value	0.813845 (rank : 48)	NC score	0.012979 (rank : 48)
Query Neighborhood Hits	73	Target Neighborhood Hits	210	Shared Neighborhood Hits	6
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

CUTL1_MOUSE
θ value	1.81305 (rank : 49)	NC score	-0.000060 (rank : 65)
Query Neighborhood Hits	73	Target Neighborhood Hits	1620	Shared Neighborhood Hits	14
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

LBXCO_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.021338 (rank : 41)
Query Neighborhood Hits	73	Target Neighborhood Hits	140	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

BRCA1_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.004408 (rank : 55)
Query Neighborhood Hits	73	Target Neighborhood Hits	436	Shared Neighborhood Hits	3
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

LBXCO_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.018929 (rank : 43)
Query Neighborhood Hits	73	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

MPP9_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.003564 (rank : 58)
Query Neighborhood Hits	73	Target Neighborhood Hits	529	Shared Neighborhood Hits	9
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

RLA1_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.016569 (rank : 45)
Query Neighborhood Hits	73	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P05386	Gene names	RPLP1, RRP1
Domain Architecture
Description	60S acidic ribosomal protein P1.

BAT3_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.004994 (rank : 53)
Query Neighborhood Hits	73	Target Neighborhood Hits	518	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

IL4RA_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.006919 (rank : 51)
Query Neighborhood Hits	73	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

KIF2C_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.002401 (rank : 61)
Query Neighborhood Hits	73	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

SAFB2_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.001112 (rank : 63)
Query Neighborhood Hits	73	Target Neighborhood Hits	720	Shared Neighborhood Hits	8
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

SLK_HUMAN
θ value	5.27518 (rank : 59)	NC score	-0.004989 (rank : 73)
Query Neighborhood Hits	73	Target Neighborhood Hits	1775	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SYCM_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.019815 (rank : 42)
Query Neighborhood Hits	73	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BYM8, Q9D6U9	Gene names	Cars2
Domain Architecture	No domain graphic available
Description	Probable cysteinyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

ZBT16_HUMAN
θ value	5.27518 (rank : 61)	NC score	-0.004908 (rank : 72)
Query Neighborhood Hits	73	Target Neighborhood Hits	1010	Shared Neighborhood Hits	4
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

AF10_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.002997 (rank : 60)
Query Neighborhood Hits	73	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

BMP2K_MOUSE
θ value	6.88961 (rank : 63)	NC score	-0.003201 (rank : 69)
Query Neighborhood Hits	73	Target Neighborhood Hits	874	Shared Neighborhood Hits	6
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

M4K5_HUMAN
θ value	6.88961 (rank : 64)	NC score	-0.004229 (rank : 70)
Query Neighborhood Hits	73	Target Neighborhood Hits	845	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MARK3_MOUSE
θ value	6.88961 (rank : 65)	NC score	-0.004514 (rank : 71)
Query Neighborhood Hits	73	Target Neighborhood Hits	919	Shared Neighborhood Hits	8
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

TEX14_MOUSE
θ value	6.88961 (rank : 66)	NC score	-0.001894 (rank : 68)
Query Neighborhood Hits	73	Target Neighborhood Hits	1333	Shared Neighborhood Hits	7
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

UBP34_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.008082 (rank : 50)
Query Neighborhood Hits	73	Target Neighborhood Hits	189	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

AMOT_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.000779 (rank : 64)
Query Neighborhood Hits	73	Target Neighborhood Hits	712	Shared Neighborhood Hits	8
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

CE025_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.016813 (rank : 44)
Query Neighborhood Hits	73	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NDZ2, Q6NXN8, Q6ZTU4, Q8IZ15	Gene names	C5orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf25.

FRS2_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.003796 (rank : 56)
Query Neighborhood Hits	73	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

KIF4A_HUMAN
θ value	8.99809 (rank : 71)	NC score	-0.000830 (rank : 67)
Query Neighborhood Hits	73	Target Neighborhood Hits	1159	Shared Neighborhood Hits	12
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF4A_MOUSE
θ value	8.99809 (rank : 72)	NC score	-0.000179 (rank : 66)
Query Neighborhood Hits	73	Target Neighborhood Hits	1033	Shared Neighborhood Hits	14
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

SETBP_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.003570 (rank : 57)
Query Neighborhood Hits	73	Target Neighborhood Hits	352	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

Hits sorted by NC score

PDE4A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	73	Target Neighborhood Hits	73	Shared Neighborhood Hits	73
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
NC score	0.997893 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	73	Target Neighborhood Hits	66	Shared Neighborhood Hits	47
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4B_HUMAN
NC score	0.996221 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	73	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
NC score	0.995849 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	73	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
NC score	0.995358 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	73	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_MOUSE
NC score	0.995167 (rank : 6)	θ value	0 (rank : 7)
Query Neighborhood Hits	73	Target Neighborhood Hits	98	Shared Neighborhood Hits	40
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4D_HUMAN
NC score	0.994788 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	73	Target Neighborhood Hits	122	Shared Neighborhood Hits	40
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE7B_MOUSE
NC score	0.937880 (rank : 8)	θ value	5.19021e-56 (rank : 13)
Query Neighborhood Hits	73	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.937748 (rank : 9)	θ value	2.57589e-55 (rank : 15)
Query Neighborhood Hits	73	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_HUMAN
NC score	0.936082 (rank : 10)	θ value	4.85792e-54 (rank : 18)
Query Neighborhood Hits	73	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
NC score	0.935236 (rank : 11)	θ value	6.56568e-51 (rank : 19)
Query Neighborhood Hits	73	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE1A_MOUSE
NC score	0.933316 (rank : 12)	θ value	3.71096e-62 (rank : 9)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1B_MOUSE
NC score	0.933038 (rank : 13)	θ value	1.23536e-57 (rank : 12)
Query Neighborhood Hits	73	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.933000 (rank : 14)	θ value	2.17557e-62 (rank : 8)
Query Neighborhood Hits	73	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_HUMAN
NC score	0.931209 (rank : 15)	θ value	2.84797e-54 (rank : 17)
Query Neighborhood Hits	73	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
NC score	0.922815 (rank : 16)	θ value	1.97229e-55 (rank : 14)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE1C_HUMAN
NC score	0.922757 (rank : 17)	θ value	1.41016e-61 (rank : 10)
Query Neighborhood Hits	73	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE9A_MOUSE
NC score	0.922698 (rank : 18)	θ value	7.77379e-44 (rank : 23)
Query Neighborhood Hits	73	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1C_MOUSE
NC score	0.921866 (rank : 19)	θ value	3.14151e-61 (rank : 11)
Query Neighborhood Hits	73	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE8B_HUMAN
NC score	0.921080 (rank : 20)	θ value	1.66964e-54 (rank : 16)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE9A_HUMAN
NC score	0.919377 (rank : 21)	θ value	3.48949e-44 (rank : 22)
Query Neighborhood Hits	73	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE8A_MOUSE
NC score	0.917215 (rank : 22)	θ value	1.51363e-47 (rank : 20)
Query Neighborhood Hits	73	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE3B_HUMAN
NC score	0.907912 (rank : 23)	θ value	1.56636e-44 (rank : 21)
Query Neighborhood Hits	73	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_HUMAN
NC score	0.892752 (rank : 24)	θ value	1.91475e-42 (rank : 24)
Query Neighborhood Hits	73	Target Neighborhood Hits	79	Shared Neighborhood Hits	38
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.890268 (rank : 25)	θ value	7.27602e-42 (rank : 25)
Query Neighborhood Hits	73	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE2A_MOUSE
NC score	0.851940 (rank : 26)	θ value	1.37539e-32 (rank : 30)
Query Neighborhood Hits	73	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.851020 (rank : 27)	θ value	1.79631e-32 (rank : 31)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.831008 (rank : 28)	θ value	2.34606e-32 (rank : 32)
Query Neighborhood Hits	73	Target Neighborhood Hits	49	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE11_MOUSE
NC score	0.830845 (rank : 29)	θ value	3.06405e-32 (rank : 34)
Query Neighborhood Hits	73	Target Neighborhood Hits	50	Shared Neighborhood Hits	39
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE10_HUMAN
NC score	0.830365 (rank : 30)	θ value	2.77775e-25 (rank : 37)
Query Neighborhood Hits	73	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_MOUSE
NC score	0.814285 (rank : 31)	θ value	2.05525e-28 (rank : 36)
Query Neighborhood Hits	73	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.810521 (rank : 32)	θ value	1.37858e-24 (rank : 38)
Query Neighborhood Hits	73	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.806826 (rank : 33)	θ value	1.24399e-33 (rank : 26)
Query Neighborhood Hits	73	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.806304 (rank : 34)	θ value	2.12192e-33 (rank : 27)
Query Neighborhood Hits	73	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.804852 (rank : 35)	θ value	2.34606e-32 (rank : 33)
Query Neighborhood Hits	73	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6B_HUMAN
NC score	0.800795 (rank : 36)	θ value	3.61944e-33 (rank : 28)
Query Neighborhood Hits	73	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6A_MOUSE
NC score	0.800545 (rank : 37)	θ value	1.98606e-31 (rank : 35)
Query Neighborhood Hits	73	Target Neighborhood Hits	45	Shared Neighborhood Hits	38
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_MOUSE
NC score	0.798898 (rank : 38)	θ value	8.06329e-33 (rank : 29)
Query Neighborhood Hits	73	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

NHS_HUMAN
NC score	0.032810 (rank : 39)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	73	Target Neighborhood Hits	198	Shared Neighborhood Hits	5
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

NELF_MOUSE
NC score	0.030468 (rank : 40)	θ value	0.0431538 (rank : 39)
Query Neighborhood Hits	73	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

LBXCO_MOUSE
NC score	0.021338 (rank : 41)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	73	Target Neighborhood Hits	140	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

SYCM_MOUSE
NC score	0.019815 (rank : 42)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	73	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BYM8, Q9D6U9	Gene names	Cars2
Domain Architecture	No domain graphic available
Description	Probable cysteinyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

LBXCO_HUMAN
NC score	0.018929 (rank : 43)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	73	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

CE025_HUMAN
NC score	0.016813 (rank : 44)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	73	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NDZ2, Q6NXN8, Q6ZTU4, Q8IZ15	Gene names	C5orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf25.

RLA1_HUMAN
NC score	0.016569 (rank : 45)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	73	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	P05386	Gene names	RPLP1, RRP1
Domain Architecture
Description	60S acidic ribosomal protein P1.

SOS1_HUMAN
NC score	0.013514 (rank : 46)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	73	Target Neighborhood Hits	274	Shared Neighborhood Hits	4
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.013169 (rank : 47)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	73	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

UBP34_HUMAN
NC score	0.012979 (rank : 48)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	73	Target Neighborhood Hits	210	Shared Neighborhood Hits	6
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

BRAP_MOUSE
NC score	0.010428 (rank : 49)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	73	Target Neighborhood Hits	409	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

UBP34_MOUSE
NC score	0.008082 (rank : 50)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	73	Target Neighborhood Hits	189	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

IL4RA_MOUSE
NC score	0.006919 (rank : 51)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	73	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

FARP1_HUMAN
NC score	0.006116 (rank : 52)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	73	Target Neighborhood Hits	241	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

BAT3_MOUSE
NC score	0.004994 (rank : 53)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	73	Target Neighborhood Hits	518	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

MLL3_MOUSE
NC score	0.004948 (rank : 54)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	73	Target Neighborhood Hits	1399	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

BRCA1_MOUSE
NC score	0.004408 (rank : 55)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	73	Target Neighborhood Hits	436	Shared Neighborhood Hits	3
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

FRS2_HUMAN
NC score	0.003796 (rank : 56)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	73	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

SETBP_MOUSE
NC score	0.003570 (rank : 57)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	73	Target Neighborhood Hits	352	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

MPP9_HUMAN
NC score	0.003564 (rank : 58)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	73	Target Neighborhood Hits	529	Shared Neighborhood Hits	9
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

PRDM2_HUMAN
NC score	0.003449 (rank : 59)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	73	Target Neighborhood Hits	1135	Shared Neighborhood Hits	10
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

AF10_HUMAN
NC score	0.002997 (rank : 60)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	73	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

KIF2C_HUMAN
NC score	0.002401 (rank : 61)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	73	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

LMNB1_HUMAN
NC score	0.001116 (rank : 62)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	73	Target Neighborhood Hits	714	Shared Neighborhood Hits	10
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

SAFB2_HUMAN
NC score	0.001112 (rank : 63)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	73	Target Neighborhood Hits	720	Shared Neighborhood Hits	8
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

AMOT_HUMAN
NC score	0.000779 (rank : 64)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	73	Target Neighborhood Hits	712	Shared Neighborhood Hits	8
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

CUTL1_MOUSE
NC score	-0.000060 (rank : 65)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	73	Target Neighborhood Hits	1620	Shared Neighborhood Hits	14
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

KIF4A_MOUSE
NC score	-0.000179 (rank : 66)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	73	Target Neighborhood Hits	1033	Shared Neighborhood Hits	14
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF4A_HUMAN
NC score	-0.000830 (rank : 67)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	73	Target Neighborhood Hits	1159	Shared Neighborhood Hits	12
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

TEX14_MOUSE
NC score	-0.001894 (rank : 68)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	73	Target Neighborhood Hits	1333	Shared Neighborhood Hits	7
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

BMP2K_MOUSE
NC score	-0.003201 (rank : 69)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	73	Target Neighborhood Hits	874	Shared Neighborhood Hits	6
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

M4K5_HUMAN
NC score	-0.004229 (rank : 70)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	73	Target Neighborhood Hits	845	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MARK3_MOUSE
NC score	-0.004514 (rank : 71)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	73	Target Neighborhood Hits	919	Shared Neighborhood Hits	8
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

ZBT16_HUMAN
NC score	-0.004908 (rank : 72)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	73	Target Neighborhood Hits	1010	Shared Neighborhood Hits	4
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

SLK_HUMAN
NC score	-0.004989 (rank : 73)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	73	Target Neighborhood Hits	1775	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).